2014 MRC성과발표회
Abstract Information
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] 기타 (
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< Abstract Sample >
Autophagy in microglia degrades extracellular β-amyloid fibrils and
regulates the NLRP3 inflammasome.
Mi-Hyang Cho1-4,$, Kwangmin Cho1-4,$, Hoe-Jin Kang1-4, Eun-Young Jeon1-4, Hun-Sik Kim3-5,
Hyung-Joon Kwon3,5, Hong-Mi Kim3,5, Dong-Hou Kim1-4, Seung-Yong Yoon1-4,*
1
Alzheimer Disease Experts Lab (ADEL), Asan Institute of Life Sciences, Asan Medical
Center, University of Ulsan College of Medicine, Seoul, Korea 2Department of Anatomy and
Cell Biology, University of Ulsan College of Medicine, Seoul, Korea 3Bio-Medical Institute of
Technology (BMIT), University of Ulsan College of Medicine, Seoul, Korea 4Cell Dysfunction
Research Center (CDRC), University of Ulsan College of Medicine, Seoul, Korea
5
Department of Medicine, Graduate School, University of Ulsan College of Medicine, Seoul,
Korea
ABSTRACT
Accumulation of β-amyloid (Aβ) and resultant inflammation are critical pathological
features of Alzheimer disease (AD). Microglia, a primary immune cell in brain, ingests and
degrades extracellular Aβ fibrils via lysosomal system. Autophagy is a catabolic process that
degrades native cellular components, however, the role of autophagy in Aβ degradation by
microglia and its effects on AD are unknown. Here we demonstrate a novel role for
autophagy in the clearance of extracellular Aβ fibrils by microglia and in the regulation of the
Aβ-induced NLRP3 (NLR family, pyrin domain containing 3) inflammasome using microglia
specific atg7 knockout mice and cell cultures. We found in microglial cultures that Aβ
interacts with MAP1LC3B-II via OPTN/optineurin and is degraded by an autophagic process
mediated by the PRKAA1 pathway. We anticipate that enhancing microglial autophagy may
be a promising new therapeutic strategy for AD.
References
[1] Autophagy, 2014 (10) 1-15
Keywords : Alzheimer disease; autophagy; β-amyloid; microglia; NALP3
2014
MRC 성과발표회
Name : 윤승용
Affiliation : 울산의대 뇌과학교실
Position : 부교수
E-mail : ysy@amc.seoul.kr
Field of Expertise : 알츠하이머병, 신경생물학
Education :
년 월
학 력 사 항
1996.3-2002.2
의학사 (울산의대)
2002.3-2004.2
의학석사 (울산의대)
2004.3-2006.2
의학박사 (울산의대)
Professional Experience : (less than 5 experiences)
년 월
경 력 사 항
2002.3-2006.2
울산의대 기초교실 조교
2006.4-2009.3
국립과학수사연구원 공보의
2009.9-현재
울산의대 기초교실 조교수
Picture
Selected Publications : (less than 5 papers)
 Mi-Hyang Cho, Kwangmin Cho, Hoe-Jin Kang, Eun-Young Jeon, Hun-Sik Kim, HyungJoon Kwon, Hong-Mi Kim, Dong-Hou Kim, Seung-Yong Yoon: Autophagy in microglia
degrades extracellular β-amyloid fibrils and regulates NALP3 inflammasome activation,
Autophagy, 10:1-15 (2014)
 Ha-Lim Song, Sungbo Shim, Dong-Hou Kim, Se-Hoon Won, Segyeong Joo, Sudong
Kim, Noo Li Jeon, and Seung-Yong Yoon: β-amyloid is transmitted via neuronal
connections along axonal membranes, Annals of Neurology, 75:88-97 (2014)
 Dong-Hou Kim, Jae-Wan Huh, Mi Jang, Jung-Hyun Suh, Tae-Wan Kim, Jeong-Su Park,
and Seung-Yong Yoon: Sitagliptin increases tau phosphorylation in the hippocampus of
rats with type 2 diabetes and in primary neuron cultures, Neurobiology of Disease, 46:5258 (2012)
 Seung-Yong Yoon, Jeong-Su Park, JungEun Choi, Jin-Myung Choi, Woo-Je Lee,
Seong-Who Kim and Dong-Hou Kim: Rosiglitazone reduces tau phosphorylation via JNK
inhibition in the hippocampus of rats with type 2 diabetes and tau transfected SH-SY5Y
cells, Neurobiology of Disease, 40:449-455 (2010)
 Seung-Yong Yoon, Young-Eun Ha, Jung-Eun Choi, Jeonghyun Ahn, Heuiran Lee, HeeSeok Kweon, Jee-Young Lee and Dong-Hou Kim: Coxsackievirus B4 uses autophagy for
replication after calpain activation in rat primary neurons, Journal of Virology, 82:1197611978 (2008)