NAME___________________________
SSN__________________
MCB 4403; PROKARYOTIC BIOLOGY
TEST #3-sample4; R. H. REEVES; NOVEMBER 29, 2006
THERE ARE THIRTY-FIVE QUESTIONS WORTH TWO POINTS EACH. THERE IS ONLY ONE
CORRECT ANSWER FOR EACH QUESTION. PLEASE CIRCLE THE CORRECT LETTER OR
PLACE THE CORRECT LETTER JUST TO THE LEFT OF THE QUESTION NUMBER. THEN
TRANSFER ALL YOUR ANSWERS TO THE "ACCUSCAN".
1.
BACTERIA THAT
A.
FOUND IN
B.
FOUND IN
C.
FOUND IN
D.
FOUND IN
E.
FOUND IN
MAKE UP THE NORMAL FLORA ARE OFTEN
THE URINE
THE BLOOD
THE LYMPH
THE THROAT
THE LUNGS
2.
IN A MUTUALISTIC RELATIONSHIP BETWEEN A MICROBE AND A HOST
A.
THE MICROBE BENEFITS
B.
THE HOST BENEFITS
C.
BOTH OF THE ABOVE
D.
NEITHER OF THE ABOVE
KEY FOR QUESTIONS 3-6. THERE IS ONLY ONE CORRECT ANSWER BUT EACH KEY WORD
MAY BE USED MORE THAN ONCE (OR NOT AT ALL).
A.
B.
C.
D.
E.
EXOTOXIN
ENDOTOXIN
TOXOID
ENTEROTOXIN
ANTITOXIN
_____3.
ITS SITE OF ACTION IS THE GASTROINTESTINAL TRACT
_____4.
IT IS GIVEN TO TREAT PERSONS WHO HAVE INGESTED BOTULISM
TOXIN
_____5.
THIS IS THE PRODUCT OF THE tox GENE OF -BACTERIOPHAGE
WHICH INFECT CORYNEBACTERIA
_____6.
THIS IS NOT A PROTEIN
7.
OPSONIZATION OF BACTERIA IS ACCOMPLISHED BY
A.
IgG BINDING TO THE BACTERIAL CELL SURFACE
B.
COMPLEMENT C9 BINDING TO THE BACTERIAL CELL
C.
BOTH OF THE ABOVE
D.
NEITHER OF THE ABOVE
MCB 4403
TEST #3-A
PAGE 2
8.
KNOWN VIRULENCE FACTORS DO NOT INCLUDE
A.
CAPSULES
B.
EXOTOXINS
C.
FIMBRIAE (OR PILI)
D.
EXTRA CELLULAR ENZYMES
E.
TOXOIDS
9.
THIS REACTION, NAD
CATALYZED BY
A.
INTERFERON
B.
THE A PORTION
C.
THE B PORTION
D.
THE A PORTION
E.
THE B PORTION
10.
+ eEF-2 --> ADPR-eEF-2 + NICOTINAMIDE,
OF
OF
OF
OF
IS
CHOLERA TOXIN
CHOLERA TOXIN
DIPHTHERIA TOXIN
DIPHTHERIA TOXIN
THE USUAL CAUSE OF INFECTIOUS (OUTBREAK) VIRAL GASTROENTERITIS IS
A.
HEPATITIS A VIRUS
B.
NOROVIRUS
C.
HEPATITIS C VIRUS
D.
ROTAVIRUS
E.
RUBELLA VIRUS
KEY FOR QUESTIONS 11-14.
BE USED MORE THAN ONCE.
A.
B.
C.
D.
E.
THERE IS ONLY ONE CORRECT ANSWER BUT EACH KEY WORD MAY
RUBELLA VIRUS
SIN NOMBRE VIRUS
DENGUE FEVER VIRUS
RESPIRATORY SYNCITIAL VIRUS
HUMAN IMMUNODEFICIENCY VIRUS-1
_____11.
ITS GENES INCLUDE gag pol AND env
_____12.
TRANSMITTED TO MAN VIA MOSQUITOES
_____13.
ALONG WITH CYTOMEGALOVIRUS IT IS KNOWN FOR INFECTING THE FETUS
_____14.
TRANSMITTED TO MAN BY RODENT URINE AND DROPPINGS
MCB 4403
TEST #3-A
PAGE 3
15.
THE PANDEMICS CAUSED BY INFLUENZA A VIRUS ARE THOUGHT TO BE A
RESULT OF NEW VIRUS STRAINS DUE TO
A.
MUTATION
B.
RECOMBINATION BETWEEN HOMOLOGOUS RNA STRANDS
C.
ANTIGENIC DRIFT
D.
RANDOM ASSORTMENT OF RNA STRANDS
E.
APPEARANCE OF NEW NEURAMINIDASE PROTEINS
16.
IN THE CLASSICAL PATHWAY, COMPLEMENT IS FIXED (THE COMPLEMENT
CASCADE INITIATED) BY
A.
RELEASE OF INTERFERON FROM LYMPHOCYTES
B.
BINDING OF ANTIBODY TO CELL SURFACE ANTIGENS
C.
BOTH OF THE ABOVE
D.
NEITHER OF THE ABOVE
KEY FOR QUESTIONS 17-21. EACH QUESTION HAS ONLY ONE ANSWER, BUT EACH
ANSWER MAY BE USED MORE THAN ONCE (OR NOT AT ALL).
A.
B.
C.
D.
E.
CIPROFLOXACIN
CEPHALOSPORIN
TRIMETHOPRIM
ISONIAZID
ERYTHROMYCIN
_____17.
SPECIFICALLY USED FOR THE TREATMENT OF TB
_____18.
IT IS A COMPETITIVE INHIBITOR OF DIHYDROFOLATE REDUCTASE
_____19.
BINDS TO THE LARGE SUBUNIT OF THE BACTERIAL RIBOSOME
_____20.
IT INHIBITS (INDIRECTLY) THE MOVEMENT OF DNA POLYMERASE
_____21.
ITS HAS SELECTIVE TOXICITY BECAUSE BACTERIA HAVE
“CROSS-LINKING” ENZYMES
22.
THE ANTIBIOTIC AUGMENTIN CONTAINS
A.
TWO beta-LACTAM DRUGS
B.
A DRUG THAT INHIBITS beta-LACTAMASES
C.
BOTH OF THE ABOVE
D.
NEITHER OF THE ABOVE
MCB 4403
TEST #3-A
PAGE 4
23.
______ DISCOVERED PENICILLIN, AND ______ & ______ DEVELOPED IT
A.
EHRLICH
FLEMING & SABIN
B.
EHRLICH
FLEMING & CHAIN
C.
SABIN
FLOREY AND CHAIN
D.
FLEMING
FLOREY AND SABIN
E.
FLEMING
FLOREY AND CHAIN
24.
IN THE INDIRECT ELISA ASSAY THE PATIENT'S SERUM ANTIBODY
REACTS WITH
A.
ANTIGEN BOUND DIRECTLY TO THE PLASTIC WELL
B.
ANTIGEN CAPTURED BY A BOUND ANTIBODY
C.
ANTIBODY BOUND TO THE PLASTIC
D.
THE CONSTANT PORTION OF AN ANTIBODY
E.
THE Fc PORTION OF AN ANTIBODY
25.
AN EXAMPLE OF ARTIFICIALLY ACQUIRED ACTIVE IMMUNITY IS
A.
DEVELOPING ANTIBODIES TO AN INJECTED TOXOID
B.
RECEIVING HORSE ANTISERUM (ANTITOXIN) TO A TOXIN
C.
BOTH OF THE ABOVE
D.
NEITHER OF THE ABOVE
26.
FIVE YEARS AFTER RECEIVING A CORNEAL TRANSPLANT, A 62 YEAR-OLD WOMAN
DEVELOPED DEMENTIA AND ATAXIA. SHE BECAME COMATOSE AND DIED THREE
WEEKS LATER. CNS CULTURES WERE NEGATIVE AND NO INFLAMMATION WAS
EVIDENT. AUTOPSY REVEAL THE PRESENCE OF BIREFRIGENT PLAQUE AND
SPONGIFORM DEGENERATION OF THE BRAIN. SHE PROBABLY DIED OF
A.
RABIES
B.
CREUTZFELDT-JAKOB DISEASE
C.
BOTULISM
D.
ASEPTIC MENINGITIS
E.
TETANUS
27.
A 14-YEAR-OLD BOY DIAGNOSED WITH GUILLAIN-BARRE SYNDROME (FACIAL
PARALYSIS) HAD A HISTORY OF HEADACHES, DIZZINESS, FEVER, SORE THROAT
AND WEAKNESS. AFTER HOSPITALIZATION HE DEVELOPED SEIZURES AND DIED
FIVE DAYS LATER. AUTOPSY REVEALED CYTOPLASMIC INCLUSIONS IN NEURONS.
HE PROBABLY HAD
A.
RABIES
B.
CREUTZFELDT-JAKOB DISEASE
C.
BOTULISM
D.
ASEPTIC MENINGITIS
E.
TETANUS
MCB 4403
TEST #3-A
PAGE 5
28.
THE NUMBER OF ANTIGEN BINDING SITES IN IgA AND IgM IS
A.
1 AND 4
B.
1 AND 5
C.
2 AND 4
D.
4 AND 5
E.
4 AND 10
29.
WHICH OF THE FOLLOWING ORGANISMS WOULD MOST LIKELY BE SENSITIVE TO
PENICILLIN G?
A.
MYCOPLASMA PNEUMONIAE
B.
STREPTOCOCCUS PYOGENES
C.
MYCOBACTERIUM LEPRAE
D.
CHLAMYDIA PSITTASI
E.
STAPHYLOCOCCUS AUREUS
30.
THIS
A.
B.
C.
D.
E.
DRUG INTERACTS WITH THE M2 PROTEIN OF INFLUENZA A VIRUS
AZT
ACYCLOVIR
PROTEASE INHIBITOR
RIBAVIRIN
AMANTADINE
KEY FOR QUESTIONS 31-35. EACH QUESTION HAS ONLY ONE ANSWER, BUT EACH
ANSWER MAY BE USED MORE THAN ONCE (OR NOT AT ALL).
A.
DIPHTHERIA VACCINE
B.
HEPATITIS A VACCINE
C.
PNEUMOCOCCAL VACCINE
D.
SABIN POLIO VACCINE
E.
ACELLULAR PERTUSSIS VACCINE
_____31.
THIS VACCINE IS TAKEN ORALLY
_____32.
A RECOMBINANT-DNA OR SUBUNIT VACCINE
_____33.
ONE OF THE TOXOID VACCINES
_____34.
MADE BY CONJUGATING A CARBOHYDRATE WITH A PROTEIN
_____35.
USED TO PREVENT FOOD-BORNE DISEASE OUTBREAKS
MCB 4403
TEST #3-A
PAGE 6
ANSWER THREE OUT OF FOUR QUESTIONS - TEN POINTS EACH
36.
COMPARE AND CONTRAST EXOTOXIN WITH ENDOTOXIN. BE SURE TO INCLUDE
DISCUSSIONS OF COMPOSITION, STRUCTURE, PHYSICAL AND BIOLOGICAL
PROPERTIES. EXPLAIN HOW THEY EXERT THEIR TOXIC ACTIVITY.
37.
COMPARE AND CONTRAST THE THREE HEPATITIS VIRUSES: HUMAN
HEPATITIS A VIRUS (HHepA), HHepB and HHepC. INCLUDE IN YOUR
DISCUSSION THE TAXONOMY, STRUCTURE AND TRANSMISSION OF EACH
VIRUS, AND DESCRIBE THE TRANSMISSION AND CLINICAL COURSE OF THE
DISEASE CAUSED BY EACH.
MCB 4403
TEST #3-A
PAGE 7
38.
FILL IN THE FOLLOWING TABLE:
ANTIBODY
IgA
IgG
APPROX
MW (kD)
LOCATION
FUNCTION (2 PTS)
320
SERUM
IgM
39.
THE TWO DRUGS CHLORAMPHENICOL AND SULFANILAMIDE ARE LOW-MOLECULARWEIGHT COMPOUNDS WITH RELATIVELY SIMPLE STRUCTURES, YET THEY WORK BY
TWO VERY DIFFERENT MECHANISMS. DESCRIBE THE ACTIVITIES OF THESE TWO
ANTIBACTERIAL DRUGS.