Applied Science University
Faculty: Pharmacy
Department: Pharmaceutical
Chemistry and Pharmacognosy
( Course Syllabus )
CourseTitle
Credit Hours
Course No.
Prerequisite
Year (semester)
Lec./Lab. Credit
Practical Pharmaceutical
Organic Chemistry 1
1
0901215
0901214‫متزامن‬
2011-2012 (1st)
2:1
Coordinator Name
Lecturer
Room No.
E-mail
Office Hours
Dr. Adel Ardakani
Dr. Adel Ardakani
Dr. Nina Sakhnini
4207
420
ardakani@asu.edu.jo
As shown on lecturers time table
Nina_sakhnini@asu.edu.jo
Course Objectives:
This course is designed to introduce students to standard laboratory techniques in organic chemistry, and
to provide experience with practical aspects of some important organic chemical reactions.
Course Description:
The course is designed to provide the student with a knowledge and understanding of the basic
experimental principles of pharmaceutical organic chemistry. The experiments will provide first hand
experience for the student and should equip him/her with the ability to solve a wide range of synthetic
chemistry problems relating to pharmaceutical products. Also to link the theoretical knowledge obtained
in both courses (0901214 & 0901224) based on their textbook Organic Chemistry, Graham Solomons
and Craig Fryhle as a reference with practical synthetic applications.
Intended Learning Outcomes:
Successful completion of this course should lead to the following learning outcomes:
Knowledge and understanding
1) To be able to understand the chemical principles,
2) To be able develop scientific processes and acquiring diverse practical skills.
3) To be able to run experimental techniques, procedures and safe laboratory practices.
Subject specific skills:
1) Separation techniques based on functional groups present.
2) Extraction of a soluble salt from a mixture by filtration and crystallization.
3) Distillation and reflux setup.
4) Synthesis of simple pharmaceutically active organic compounds.
5) To describe detailed mechanisms for common reactions.
6) Draw their structures.
Intellectual skills
1. To be able to give systematic names to simple organic compounds and poly functional group.
2. To achieve an understanding of the behavior of organic compounds and to establish a foundation
for studies into natural and synthetic products of pharmaceutical interest.
3. To acquire an understanding of methods used in synthesis, and mechanism of reactions.
1
Course Contents:
2.
1-1 to 3-5 Introductory laboratory.
09-10-2011
Reference
(page)
05
3.
4-1 Separation of Benzoic Acid from Acetanilide mixture.
16-10-2011
17
4.
4-3 Synthesis of Acetanilide.
23-10-2011
22
5.
4-4 Synthesis of p-nitroacetanilide
30-10-2011
24
1st Exam
Week
Topics
Topic Date
Notes
(06*-10)-11-2011
6.
7.
Recrystallization of acetanilide and p-nitroacetanilide
13-11-2011
26
1st Exam
8.
4-9 Haloform Reactions: Synthesis of Iodoform
20-11-2011
32
1st Exam
9.
27-11-2011
36
04-12-2011
20
11.
4-5 Reaction of Esterification: Preparation of n-Butyl
acetate.
4-2 Separation of a mixture of water-insoluble compounds
by chemical extraction (Practical and Theoritical Quiz)
4-8 Synthesis of azodystuffs.
11-12-2011
28
12.
4-8-1 Synthesis of phenyl azo-2 naphthol.
4-12 Synthesis of Quinoline Derivative. (a)
18-12-2011
42
10.
15.
2nd Exam
2nd Exam
25*-12-2011
13.
14.
Out of 10,5
respectively
4-12 Synthesis of Quinoline Derivative. (b)
- Theoritical quiz (Esterification + P-nitroAcetanilide
synthesis)
F I N A L E X A M I N A T I O N W EE K
01*-01-2012
42
Out of 10
marks
08-01-2012
* Holiday
Course quality improvement:
Grade Distribution :
Assessment
Grade
30
10
20
40
- Quizzes
- Reports
- Evaluation
- Final Examination
Date
Reading List:
Text Book
The College Manual of Organic Chemistry.
Other
References
Organic Chemistry, Graham Solomons and Craig Fryhle, 9th edition, John Wiley
and sons, Inc, 2007.
Last updated on
27/9/2011
by : Dr. Adel Ardakani
2