Medical
Microbiology（巴班）教学大纲
Chapter 1
Introduction, basic bacteriology
[Requirement]
Master the definition of microorganism
Master the classification of microorganism
[Class hour: 0.5 hours ]
[Content]
1. Microbes : Definition, Classification, Distribution of Microorganisms
2. Microbiology
Chapter 2
Structure of bacterial cells
[Requirement]
Master the structure of bacteria and their functions
Master the following concepts :
1.plasmid 2. flagellum 3. pillus 4. capsule
5.L-form bacterium 6. mesosome 7. lipopolysaccharide(LPS)
Understand the size and shape of bacteria.
[Class hour: 2 hours ]
[Outline]
I . Size of bacteria
II Shape of bacteria
III Superficial layer and specific structure
IV Bacteria L—Forms
Chapter 3
Growth
[Requirement]
Master the reason that obligate anaerobes can’t grow in free oxygen condition.
Master the metabolic products of bacteria.
Master the following concepts: pyrogen
Understand bacterial nutrition.
Understand the growth curve of bacteria
[Class hour: 2 hours ]
[Outline]
I . Bacterial nutrition
II Bacterial growth and reproduction
III Growth curve of B.
Chapter 4 Genetics
[Requirement]
Master the characteisticrs of plasmid.
Master the mechanism of mutation and gene transfer of bacteria.
Master the following concepts :
1. Plasmid
2. Mutation 3. transformation 4. transduction
5. conjuqation
6. lysogenic state 7. lysogenic phage (temperate phage)
8. lysogenec bacteria 9. prophage
[Class hour: 1 hours ]
[Outline]
I. Genetic substance
1. chromosome
2. Plasmid
3. phage.
Interrelation between phage and bacteria : lysogenic state
II.
Mechanism of bacterial variation mutation.
1.Mutation
2. genetic transfer: transformation, transduction, conjuqation
Chapter 5
Normal flora
[Requirement]
Master the initiate infection of opportunistic pathogenic B.
Master the functions of normal flora
Master the following concepts :
1. normal flora 2. opportunistic pathogenic B
[Class hour: 1 hours ]
[Outline]
Concept
1. normal flora: The microorgomison that parasitize on the body surface
or tracts connecting with external, don’t harm the host in ordinary
condition.
2. opportunistic pathogenic B
some bacteria are unable to cause in ordinary condition , they
initiate infection.
If(1) they leave their ordinary habitant and gain access to other part.
Owing to the wide use of antibiotic, hormone and anti-concer druges.
1. Distribution of normal flora
2. Role of normal flora.
3. Biological barrier: antagonism
4. nutrient synthesize : aa. VB. K. enhance absorb.
5. immue: enhance and develop and maturation of immue system
Flore disequilibrium (dysbacteriosis)
Chapter 6 Pathogenesis
[Requirement]
Master the mechanism of bacterial virulence
Master the following concepts : 1.Toxemia 2.bacteremia 3.septicemia
4.pyemia
[Class hour: 3 hours ]
[Outline]
Virulence:
I. Invasiveness
II. Toxin
III. Occurance and development of infection
Chapter 7
Host Defenses
[Requirement]
Understand the composition of host defenses: innate defenses and acquired
defenses.
[Class hour: 0.5 hours ]
[Outline]
Composition of host defenses:
I. innate defenses
II. acquired defenses.
Chapter 10 Antimicrobial Drugs: Resistance
[Requirement]
Understand the genetic basis of resistance of bactericidal drugs.
[Class hour: 0.5 hours ]
[Outline]
Genetic basis of resistance of bactericidal drugs.
I. chromosome-mediated resistance
II. plasmid-mediated resisitance
III. transposon-mediated resisitance
PART III Basic VirologyChapter 28
Structure
[Requirement]
Master the chemical composition and function of viruses
Master the following concepts :
1. Obligate intracellular parasites
2. Virion
3. Defective virus
Understand the characteristics of Viral Genetics.
4. Prion
[Class hour: 1.5 hours ]
1. Basic Concepts of Viruses2. Virology3
3. Significance of Studing Virology for Life
Science
4. Concept of virion, size and shape
5. structure of virus
6. Atypical viruslike agents: defective virus, prion.
Chapter 29
[Requirement]
Replication
Master the major feature of the replication cycle of viruses.
[Class hour: 1.5 hours ]
[Content]
1. Replication cycle
Chapter 30 Genetics and Gene Therapy
[Requirement]
Master the following concepts : 1. Recombination
[Class hour: 1 hours ]
[Content]
1. mutation, ts mutant
2. Recombination and Reassortment
3. complementation
4. Phenotypic mixing
2. Reassortment
Chapter 31 Pathogenesis
[Requirement]
Master the the pathways of viral infections and the viruses which can result in
vertical infection .
Master the following concepts :
1.vertical transmission 2 . CPE
3. latent infection 3. slow virus infection
Understand the pathogenesis and immunopathogenesis of viral infection.
[Class hour: 2 hours ]
[Content]
1. The pathways of viral infections
2. The type of viral infection
3. Pathogenesis and immunopathogenesis of Viral Infection
Chapter 33 Host Defenses
[Requirement]
Master the the antiviral activity of IFN.
Master the following concepts : 1.Interferon (IFN) 2. AVP 3. neutrilizing antibody
Understand the classification of IFN and the production of IFN.
[Class hour: 2 hours ]
[Content]
1. IFN concept, classification,production,
2. Action of IFN(anti-virus)
3. characteristics of IFN
4. Neutrilizing antibody
5.CTL
Chapter 34 Laboratory Diagnosis
[Requirement]
Understand the examination methods of viral infection.
[Class hour: 1 hours ]
[Content]
1. identification in cell culture.(CPE, inclusion body).
2. Serologic procedures.
3. Detection of viral nucleic acid.
Chapter 35 Antiviral Drugs
[Requirement]
Understand the characteristics of antiviral agents.
[Class hour: 1 hours ]
[Content]
1. inhibition of early events
2. inhibition of viral nucleic acid synthesis
3. inhibition of viral protein synthesis
Chapter 36 Viral vaccine
[Requirement]
Understand the vaccines of viruses
[Class hour: 0.5 hours ]
[Content]
1. immunization prevention of viral infection
2. artificial passive immunizaton