1 -Concerning benzodiazepines:
A- They produce pharmacokinetic tolerance to their hypnotic effects.
B- Midazolam is used as anxiolytic when sedation is not required.
C- Sudden withdrawal produces severe withdrawal symptoms compared to barbiturates.
D- Both A & B.
E- None of the above.
2 -Concerning benzodiazepines:
A- They act as agonist on GABAB receptors.
B- Concurrent use of diazepam and cimetidine may lead to excessive sedation & drowsiness.
C- They augment GABA action by inhibiting its metabolism.
D- Both B & C.
E- None of the above
3 – Benzodiazepines produce all of the following effects Except:
A- Anticonvulsant effect.
B- Anxiolytic action.
C- Analgesic.
D- Hypnotic action.
E- Sedation.
4- Flumazenil:
A- It is used to diagnose & treat benzodiazepine toxicity.
B- It is a specific antidote for barbiturate overdose.
C- It is a competitive GABAA receptor antagonist.
D- Both A & C.
E- None of the above.
5- Concerning barbiturates:
A- Elimination of I.V. thiopental depends mainly on its redistribution to fat tissues.
B- Phenobarbital is mainly used as I.V. anesthetic for long operations.
C- Phenobarbital is indicated for patients with acute porphyria.
D- Both A & B.
E- Both B & C.
6 - Concerning barbiturates:
A- They can be used as antipsychotics.
B- They do not produse tolerance.
C- They inhibit the REM sleep.
D- Both B & C.
E- All of the above.
7 - Buspirone:
A- It acts as a selective GABA receptor agonist.
B- It is used to reverses the hypnotic effect of diazepam.
C- It is used in treatment of diazepam withdrawal.
D - Both A & B.
E- None of the above.
8 – Concerning benzodiazepines:
A- Diazepam is recommended for patients with liver impairment.
B- They are used as anxiolytics when sedation is not required.
C- They can be used in treatment of panic attacks and withdrawal from alcohols.
D - Both A & C.
E- None of the above.
9 – Concerning barbiturates:
A- They may cause polyuria due to stimulation of ADH release.
B- Thiopental is mainly metabolized by the liver and excreted by kidney.
C- Drugs with high lipid solubility produce faster hypnotic effect.
D - Both B & C.
E- None of the above.
10 - Which of the following measures can be used in treatment of phenobarbital
toxicity?
A- Alkalinization of the urine.
B- Analeptic drugs.
C- Oxygen therapy and I.V. fluids.
D - Both A & B.
E- All of the above.
Which of the following statements is true or false?
T F 1- Benzodiazepines increase the frequency of chloride channel openings.
T F 2- Zolpidem is mainly used as anxiolytic.
T F 3- Continous use of buspirone may lead to physical dependence.
T F 4- Benzodiazepines have a very narrow therapeutic index.
T F 5- Benzodiazepines are considered as inverse agonists.
T F 6- Benzodiazepines and barbiturated decrease the onset of sleep.
T F 7- Barbiturates increase the duration of channel opening, but do not change the
frequency.
T F 8- Barbiturates do not produce any analgesic or antipsychotic actions.
T F 9- Thiopental has a brief duration of action due to its rapid redistribution from
brain to other tissues.
T F 10- Buspirone is used to reverse the hypnotic action of benzodiazepines.