John D Sutherland: Curriculum vitae
Personal
Date of birth
24.07.1962
Marital status
Married 1994, two daughters born 2007 and 2010.
Academic Qualifications and Positions
1980-1984
Lincoln College, Oxford: BA Hons First Class in Chemistry,
Open Exhibitioner, Open Scholar, Lord Crewe Scholar,
Distinction in Supplementary Biochemistry, Turbutt Prize for
Practical Organic Chemistry.
1984
Harvard University, USA: Kennedy Scholar and Teaching
Fellow.
1984-1988
Balliol College, Oxford: D.Phil., 'Genetic Engineering of
Penicillin Biosynthesis'.
1987-1990
Merton College, Oxford: Junior Research Fellow.
1990-1998
Oxford University: University Lecturer in Organic Chemistry.
1996-1998
Lincoln and Merton Colleges, Oxford: College Lecturer in
Organic Chemistry.
1998-2010
Manchester University: Professor of Biological Chemistry.
2010-
Medical Research Council Laboratory of Molecular Biology,
Cambridge: Group Leader.
Other Positions
1990-1998
The Oxford Centre for Molecular Sciences: Full Member.
1991-1994
Eli Lilly & Co., Indianapolis, USA: Consultant.
1994-2010
DSM Anti-Infectives (formerly Gist-brocades bv), Delft, The
Netherlands: Consultant.
1994-7
BBSRC: Member of the Biomolecular Sciences Committee.
1996-7
BBSRC: Member of
Applications Initiative.
1997
Cambridge Combinatorial: Consultant.
the
Structural
Biology
Design
1999
Maxygen Inc. Redwood City CA, USA: Consultant.
2000-2002
Sense Proteomic: Cofounder then consultant.
2000-2002
Millennium Pharmaceuticals: Consultant.
2002-2008
UK Representative on EU COST Action D27.
2003-
Elucigen: Founder.
2008-
UK Representative on EU CMST Action CM0703.
2013-
Simons Investigator and member of the Steering Committee
for the Simons Collaboration on the Origin of Life
Honours
2009
The Max Tishler Prize Lectureship, Harvard University, USA.
2011
The Royal Society of Chemistry Tilden Prize.
2012
Co-winner of the Origin of Life Challenge
2014
The Royal Society Darwin Medal
Publications
1
'Purification and Characterisation of Cloned Isopenicillin N Synthase' J.E.
Baldwin, S.J. Killin, A.J. Pratt, J.D. Sutherland, N.J. Turner, M.J.C. Crabbe,
E.P. Abraham and A.C. Willis, J. Antibiot. 1987, 40, 652.
2
'Substrate
Specificity
of
Cloned
Deacetoxycephalosporin
C/Deacetylcephalosporin C Synthase' J.E. Baldwin, R.M. Adlington, N.P.
Crouch, J.B. Coates, J.W. Keeping, C.J. Schofield, W.A. Shuttleworth and
J.D. Sutherland, J. Antibiot. 1988, 41, 1694.
3
'Penicillin Biosynthesis: Stereochemistry of Desaturative and Hydroxylative
Pathways
from
L--Aminoadipoyl-L-cysteinyl-D-isodehydrovaline
with
Isopenicillin N Synthase' J.E. Baldwin, R.M. Adlington, L.G. King, M.F. Parisi,
W.J. Sobey, J.D. Sutherland and H.-H. Ting, JCS Chem. Comm. 1988, 1635.
4
'High Level Expression in Escherichia coli of a Fungal Gene Under the
Control of Strong Promoters' J.E. Baldwin, J.M. Blackburn, C.J. Schofield and
J.D. Sutherland, FEMS Microbiol. Lett. 1990, 68, 45.
5
'Acyl Coenzyme A: 6-Aminopenicillanic Acid Acyltransferase from Penicillium
chrysogenum and Aspergillus nidulans' P.A. Whiteman, E.P. Abraham, J.E.
Baldwin, M.D. Fleming, C.J. Schofield, J.D. Sutherland and A.C. Willis, FEBS
Lett. 1990, 262, 342.
6
'High Level Soluble Soluble Expression of Isopenicillin N Synthase Isozymes
in E. coli' J.E. Baldwin, J.M. Blackburn and J.D. Sutherland, Tetrahedron
1991, 47, 5991.
7
'Site-specific Forced Misincorporation Mutagenesis using Modified T7 DNA
Polymerase' J.E. Baldwin, S.L. Martin and J.D. Sutherland, Protein
Engineering 1991, 4, 579.
8
'High Level Soluble Expression and Purification of Deacetoxycephalosporin
C/Deacetylcephalosporin C Synthase' J.E. Baldwin, J.M. Blackburn, R.J.
Heath and J.D. Sutherland, Bioorg. Med. Chem. Lett. 1992, 2, 663.
9
'Substrate Specificity of Soluble Expression and Purification of
Deacetoxycephalosporin C/Deacetylcephalosporin C Synthase' J.E. Baldwin,
J.M. Blackburn, R.J. Heath and J.D. Sutherland, Bioorg. Med. Chem. Lett.
1992, 2, 663.
10 'On the Production of ,-Heterodimeric Acyl Coenzyme A: Isopenicillin N
Acyltransferase of Penicillium chrysogenum. Studies Using a Recombinant
Source' R.T. Aplin, J.E. Baldwin, S.C.J. Cole, J.D. Sutherland and M.B.
Tobin, FEBS Lett. 1993, 319, 166.
11 'The Requirement for Subunit Interaction in the Production of Penicillium
chrysogenum Acyl Coenzyme A: Isopenicillin N Acyltransferase in
Escherichia coli' M.B. Tobin, J.E. Baldwin, S.C.J. Cole, J.R. Miller, P.L.
Skatrud and J.D. Sutherland, Gene, 1993, 132, 199.
12 'Directed Evolution of Novel Biosynthetic Pathways: Growth of an Escherichia
coli Proline Auxotroph on 1-Pyrroline-2-carboxylic Acid' J.D. Sutherland, E.J.
Wilson and M.C. Wright, Bioorg. Med. Chem. Lett. 1993, 3, 1185.
13 'Reduction of 1-Pyrroline-2-carboxylic Acid to Proline by an Escherichia coli
Proline Auxotroph' M.L. Lewis, S.L. Martin, C.J. Rowe, J.D. Sutherland, E.J.
Wilson and M.C. Wright, Bioorg. Med. Chem. Lett. 1993, 3, 1189.
14 'The Effect of pH on the Solution Structure of 1-Pyrroline-2-carboxylic Acid
as Revealed by NMR and Electrospray Mass Spectroscopy' M.L. Lewis, C.J.
Rowe, N. Sewald, J.D. Sutherland, E.J. Wilson and M.C. Wright, Bioorg.
Med. Chem. Lett. 1993, 3, 1193.
15 'Reduction of 1-Pyrroline-2-carboxylic Acid to Proline in Escherichia coli:
Lack of Involvement of Glutamate Dehydrogenase and 1-Pyrroline-5carboxylate Reductase' M.L. Lewis, S.L. Martin, C.J. Rowe, J.D. Sutherland,
E.J. Wilson and M.C. Wright, Bioorg. Med. Chem. Lett. 1993, 3, 1197.
16 'The Acyltransferase Genes from A. nidulans and P. chrysogenum:
Production in and Activity from E. coli Producing the 40kDa Protein' M.B.
Tobin, M.D. Fleming, J.D. Sutherland, P.A. Whiteman, E.P. Abraham, J.E.
Baldwin, P.L. Skatrud and J.R. Miller in H. Kleinkauf and H. van Dohren
(Eds.), '50 Years of Penicillin Application: History and Trends' Technische
Universitat Berlin, 1993, pp. 231-232.
17 'Substrate Specificity of Recombinant Streptomyces clavuligerus
Deacetoxycephalosporin C Synthase' N. Morgan, I.A.C. Pereira, I.A.
Anderson, R.M. Adlington, J.E. Baldwin, S.C.J. Cole, N.P. Crouch and J.D.
Sutherland, Bioorg. Med. Chem. Lett. 1994, 4, 1595.
18 'Novel Stereochemical Manipulations of the Penicillin Nucleus' J.E. Baldwin,
R.Y. Chan and J.D. Sutherland, Tetrahedron Lett. 1994, 35, 5519.
19 'Acyl-coenzyme A: Isopenicillin N Acyltransferase from Penicillium
chrysogenum: Effect of Amino Acid Substitutions at Ser227, Ser230 and
Ser309 on Proenzyme Cleavage and Activity' M.B. Tobin, S.C.J. Cole, S.
Kovacevic, J.R. Miller, J.E. Baldwin and J.D. Sutherland, FEMS Microbiol.
Lett. 1994, 121, 39.
20 'Directed Evolution of Novel Biosynthetic Pathways: Construction of a
Randomly Mutated Gene Library in an Escherichia coli Proline Auxotroph and
Selection for Growth on Potential Proline Precursors' J.D. Sutherland, E.J.
Wilson and M.C. Wright, Bioorg. Med. Chem. Lett. 1994, 4, 2551.
21 'Directed Evolution of Novel Biosynthetic Pathways: Overexpression of
Leucine Aminopeptidase Allows an Escherichia coli Proline Auxotroph to
Grow Faster on Prolinamide' A.J. Little, J.D. Sutherland, E.J. Wilson and
D.A.J. Wood-Collins, Bioorg. Med. Chem. Lett. 1994, 4, 2555.
22 'Studies on a Potentially Prebiotic Synthesis of RNA' J.D. Sutherland and
G.W. Weaver, Tetrahedron Lett. 1994, 35, 9105.
23 'Synthesis of Bis(glycoaldehyde) Phosphodiester and Mixed GlycoaldehydeTriose Phosphodiesters' J.D. Sutherland and G.W. Weaver, Tetrahedron
Lett. 1994, 35, 9109.
24 'Solution Structures of Bis(glycoaldehyde) Phosphodiester and Mixed
Glycoaldehyde-Triose Phosphodiesters' J.D. Sutherland and G.W. Weaver,
Tetrahedron Lett. 1994, 35, 9113.
25 'Syntheis of Potentially Prebiotic RNA Precursors: Adenine and Uracil
Derivatives' J.B. Pavey, J.D. Sutherland, G.W. Weaver and J.N. Whitfield,
Tetrahedron Lett. 1995, 36, 2657.
26 'A Heuristic Approach to the Analysis of Enzymic Catalysis: Reaction of -(L-Aminoadipoyl)-L-cysteinyl-D--aminobutyrate and -(L--Aminoadipoyl)-Lcysteinyl-D-allylglycine Catalysed by Isopenicillin N Synthase Isozymes' J.M.
Blackburn, J.D. Sutherland and J.E. Baldwin, Biochemistry, 1995, 34, 7548.
27 'Synthesis of (2R, 3S)-[4-2H3]-Valine: Application to the Study of Ring
Expansion of Penicillin N by Deacetoxycephalosporin C Synthase from
Streptomyces clavuligerus' J.E. Baldwin, R.M. Adlington, N.P. Crouch, L.C.
Mellor, N. Morgan, A.M. Smith and J.D. Sutherland, Tetrahedron, 1995, 51,
4089.
28 'Amino Acid Substitutions in the Cleavage Site of Acyl-coenzyme A:
Isopenicillin N Acyltransferase from Penicillium chrysogenum: Effect on
Proenzyme Cleavage and Specificity' M.B. Tobin, S.C.J. Cole, J.R. Miller,
J.E. Baldwin and J.D. Sutherland, Gene 1995, 162, 29.
29 'Studies on the Reactivity of Bisglycoaldehyde Phosphodiester in Alkaline
Solution' S.D. Cook and J.D. Sutherland, Tetrahedron Lett. 1996, 37, 5779.
30 'Syntheis of Potentially Prebiotic RNA Precursors: Cytosine and Guanine
Derivatives' J.N. Whitfield and J.D. Sutherland, Tetrahedron Lett. 1997, 38,
1532.
31 'Prebiotic Chemistry: A Bioorganic Perspective' J.D. Sutherland and J.N.
Whitfield, Tetrahedron 1997, 53, 11493.
32 'Studies on A Potentially Prebiotic Synthesis of RNA' J.D. Sutherland and
J.N. Whitfield, Tetrahedron 1997, 53, 11595.
33 'Killing Two Birds with One Stone: A Chemically Plausible Scheme for Linked
Nucleic Acid Replication and Coded Peptide Synthesis' J.D. Sutherland and
J.M. Blackburn, Chemistry & Biology 1997, 4, 481.
34 'Synthesis and Solution Structures of Aminoacyl Compounds of Potential
Prebiotic Significance' J.D. Sutherland and S.D. Cook, Tetrahedron Lett.
1998, 39, 3299.
35 'Analysis of the Conversion of -(L--aminoadipoyl)-L-cysteinyl-D-aminobutyrate by Active Site Mutants of Aspergillus nidulans Isopenicillin N
Synthase' C.J. Rowe, C.P. Shorrock, T.D.W. Claridge and J.D. Sutherland,
Chemistry & Biology 1998, 5, 229.
36 ‘A Practical Method for the Combinatorial Synthesis of Peptide Aldehydes’
B.J. Hall and J.D. Sutherland, Tetrahedron Lett. 1998, 39, 6593.
37 'The Salt Dependence of DNA Recognition by NF-B p50: a Detailed Kinetic
Analysis of the Effects on Affinity and Specificity' D.J. Hart, R.E. Speight,
M.A. Cooper, J.D. Sutherland and J.M. Blackburn, Nucl. Acids Res. 1999, 27,
1063.
38
'Enzyme Evolution' J.D. Sutherland,Chem. Ind. 1999, 745-748.
39
'Evolutionary Optimisation of Enzymes' J.D. Sutherland, Curr. Opin. Chem.
Biol. 2000, 4, 263-269.
40
'Catalyst Screening Using an Array of Thermistors' J.D. Sutherland and A.R.
Connolly, Angew. Chem. Int. Ed. 2000, 39, 4268-4271.
41
'Analysis of the NF-B p50 Dimer Interface by Diversity Screening' D.J. Hart,
R.E. Speight, J.D. Sutherland and J.M. Blackburn, J. Mol. Biol. 2001, 310,
563-575.
42
'A New Plasmid Display Technology for the In Vitro Selection of Functional
Phenotype-Genotype Linked Proteins' R.E. Speight, D.J. Hart, J.D.
Sutherland and J.M. Blackburn, Chemistry & Biology 2001, 8, 951-965.
43
'Synthesis and Properties of Glycolaldehyde Di- and Triphosphate' A.J.
Lawrence and J.D. Sutherland, Synlett 2002, 170-172.
44
'Purification, Crystallization and Preliminary X-ray Diffraction of Cys103Ala
Acyl Coenzyme A:isopenicillin N Acyltransferase from Penicillium
chrysogenum' C.M.H. Hensgens, E.A. Kroezinga, B.A. van Montfort, J.-M.
van der Laan, J.D. Sutherland and B.W. Dijkstra, Acta Cryst. 2002, D58, 716718.
45
'A Novel Cell-Based Scintillation Proximity Assay for Studying Protein
Function and Activity In Vitro Using Membrane Soluble Scintillants' S.J.
Culliford, P. McCauley, A.J. Sutherland, M. McCairn, J.D. Sutherland, J.M.
Blackburn and R.Z. Kozlowski Biochem. Biophys. Res. Commun. 2002, 296,
857-863.
46
'Mutational Analysis of the Kinetics and Thermodynamics of Transcription
Factor NF-B Homodimerisation' Y.S.N. Day, S.L. Bacon, Z. HughesThomas, J.M. Blackburn and J.D. Sutherland ChemBioChem 2002, 3, 11921199.
47
'Synthesis of Cytidine Ribonucleotides by Stepwise Assembly of the
Heterocycle on a Sugar Phosphate' A.-A. Ingar, R.W.A. Luke, B.R. Hayter
and J.D. Sutherland ChemBioChem 2003, 6, 504-507.
48
'Exploratory Studies to Investigate a Linked Prebiotic Origin of RNA and
Coded Peptides' V. Borsenberger, M.A. Crowe, J. Lehbauer, J. Raftery, M.
Helliwell, K. Bhutia, T. Cox and J.D. Sutherland Chem. Biodivers. 2004, 1,
203-246.
49 'Exploratory Studies to Investigate a Linked Prebiotic Origin of RNA and
Coded Peptides. 2nd Communication: Derivation and Reactivity of Xylose
Phosphates' J.M. Smith, V. Borsenberger, J. Raftery, and J.D. Sutherland
Chem. Biodivers. 2004, 1, 1418-1451.
50 'Exploratory Studies to Investigate a Linked Prebiotic Origin of RNA and
Coded Peptides. 3rd Communication: Behaviour of 5-Amino-1H-imidazole-4carbonitrile Derivatives' K. Ace and J.D. Sutherland Chem. Biodivers. 2004,
1, 1678-1693.
51 'Exploratory Studies to Investigate a Linked Prebiotic Origin of RNA and
Coded Peptides. 4th Communication: Further Observations Concerning
Pyrimidine Nucleoside Synthesis by Stepwise Nucleobase Assembly' N.
Saewan, M.A. Crowe, M. Helliwell, J. Raftery, K. Chantrapromma and J.D.
Sutherland Chem. Biodivers. 2005, 2, 66-83.
52 'An approach to prevent aggregation during the purification and crystallization
of wild type acyl coenzyme A: isopenicillin N acyltransferase from Penicillium
chrysogenum' H. Yoshida, C.M.H. Hensgens, J.-M. van der Laan, J.D.
Sutherland, D.J. Hart and B.W. Dijkstra Protein Expression and Purification
2005, 41, 61-67.
53 'Expeditious, potentially primordial, aminoacylation of nucleotides' J.-P. Biron,
A.L. Parkes, R. Pascal and J.D. Sutherland Angew. Chem. Int. Ed. 2005, 44,
6731-6734.
54 'Aldolisation of bis(glycolaldehyde) phosphate and formaldehyde' J.M. Smith
and J.D. Sutherland ChemBioChem 2005, 6, 1980-1982.
55 'Substrate ambiguity and catalytic promiscuity within a bacterial proteome
probed by an easy phenotypic screen for aldehydes' G. Krebs, L. Hugonet
and J.D. Sutherland Angew. Chem. Int. Ed. 2006, 45, 301-305.
56 'Reaction of cytidine nucleotides with cyanoacetylene: support for the
intermediacy of nucleoside-2',3'-cyclic phosphates in the prebiotic synthesis
of RNA' M.A. Crowe and J.D. Sutherland ChemBioChem 2006, 7, 951-956.
57 'Direct Assembly of Nucleoside Precursors from Two- and Three-carbon
Units' C. Anastasi, M.A. Crowe, M.W. Powner and J.D. Sutherland Angew.
Chem. Int. Ed. 2006, 45, 6176-6179.
58 'Antimalarial tetranortriterpenoids from the seeds of Lansium domesticum
Corr.' N. Saewan, J.D. Sutherland and K. Chantrapromma Phytochem. 2006,
67, 2288-2293.
59 'Two Step Potentially Prebiotic Synthesis of -D-Cytidine-5'-phosphate from
D-Glyceraldehyde-3-phosphate' C. Anastasi, M.A. Crowe and J.D. Sutherland
J. Am. Chem. Soc. 2007, 129, 24-25.
60 'Looking Beyond the RNA Structural Neighborhood for Potentially Primordial
Genetic Systems' J.D. Sutherland Angew. Chem. Int. Ed. 2007, 46, 23542356.
61 'Formation of Potentially Prebiotic Amphiphiles by Reaction of -Hydroxy-nalkylamines with Cyclotriphosphate' L.B. Mullen and J.D. Sutherland Angew.
Chem. Int. Ed. 2007, 46, 4166-4168.
62 'RNA: Prebiotic Product, or Biotic Invention?' C. Anastasi, F.F. Buchet, M.A.
Crowe, A.L. Parkes, M.W. Powner, J.M. Smith and J.D. Sutherland Chem.
Biodivers. 2007, 4, 721-739.
63 'On the Prebiotic Synthesis of Ribonucleotides: Photoanomerisation of
Cytosine Nucleosides and Nucleotides Revisited' M.W. Powner, C. Anastasi,
M.A. Crowe, A.L. Parkes, J. Raftery and J.D. Sutherland ChemBioChem
2007, 8, 1170-1179.
64 'Simultaneous Nucleotide Activation and Synthesis of Amino Acid Amides by
a Potentially Prebiotic Multi-component Reaction' L.B. Mullen and J.D.
Sutherland Angew. Chem. Int. Ed. 2007, 46, 8063-8066.
65 'The Search for a Potentially Prebiotic Synthesis of Nucleotides via
Arabinose-3-phosphate and its Cyanamide Derivative' C. Anastasi, F.F.
Buchet, M.A. Crowe, M. Helliwell, J. Raftery and J.D. Sutherland Chem. Eur.
J. 2008, 14, 2375-2388.
66 'Potentially Prebiotic Passerini-Type Reactions of Phosphates'
Sutherland, L.B. Mullen and F.F. Buchet Synlett 2008, 2161-2163.
J.D.
67 'Potentially Prebiotic Synthesis of Pyrimidine -D-Ribonucleotides by
Photoanomerization/Hydrolysis of -D-Cytidine-2-Phosphate' M.W. Powner
and J.D. Sutherland ChemBioChem 2008, 9, 2386-2387.
68 'Engineering of Penicillium chrysogenum for Fermentative Production of a
Novel Carbamoylated Cephem Antibiotic Precursor' D.M. Harris, I.
Westerlaken, D. Schipper, Z.A. van der Krogt, A.K. Gombert, J.D.
Sutherland, L.M. Raamsdonk, M.A. van den Berg, R.A.L. Bovenberg, J.T.
Pronk and J.-M. Daran Metabol. Eng. 2009, 11, 125-137.
69 'Synthesis of Activated Pyrimidine Ribonucleotides in Prebiotically Plausible
Conditions' M.W. Powner, B. Gerland and J.D. Sutherland Nature 2009, 459,
239-242.
70 'Structures of an Isopenicillin N Converting Ntn-Hydrolase Reveal Different
Catalytic Roles for the Active Site Residues of Precursor and Mature
Enzyme' M. Bokhove, H. Yoshida, C.M.H. Hensgens, J.M. van der Laan, J.D.
Sutherland and B.W. Dijkstra Structure 2010, 18, 301-308.
71 ‘Ribonucleotides’ J.D. Sutherland Cold Spring Harb. Perspect. Biol. 2010, 2,
a005439.
72 ‘Phosphate-mediated Interconversion of Ribo- and Arabino-configured
Prebiotic Nucleotide Intermediates’ M.W. Powner and J.D. Sutherland
Angew. Chem. Int. Ed. 2010, 49, 4641-4643.
73 ‘A Stereoelectronic Effect in Prebiotic Nucleotide Synthesis’ A. Choudhary,
K.J. Kamer, M.W. Powner, J.D. Sutherland and R.T. Raines ACS Chem. Biol.
2010, 5, 655-657.
74 ‘Chemoselective Multicomponent One-pot Assembly of Purine Precursors in
Water’ M.W. Powner, J.D. Sutherland and J.W. Szostak J. Am. Chem. Soc.
2010, 24, 16677-16688.
75 'The Origins of Nucleotides' M.W. Powner, J.D. Sutherland and J.W. Szostak,
Synlett 2011, 1956-1964.
76 ‘Prebiotic Chemistry: a New Modus Operandi’ M.W. Powner and J.D.
Sutherland, Phil. Trans. R. Soc. B 2011, 366, 2870-2877.
77 ‘Prebiotic Synthesis of Simple Sugars by Photoredox Systems Chemistry’ D.
Ritson and J.D. Sutherland, Nature Chem. 2012, 4, 895-899.
78 ‘Detection of Potential TNA and RNA Nucleoside Precursors in a Prebiotic
Mixture by Pure Shift Diffusion-Ordered NMR Spectroscopy’ S. Islam, J.A.
Aguilar, M.W. Powner, M. Nilsson, G.A. Morris and J.D. Sutherland, Chem.
Eur. J. 2013, 19, 4586-4595.
79 ‘Prebiotically Plausible Oligoribonucleotide Ligation Facilitated by
Chemoselective Acetylation’ F.R. Bowler, C.K.W. Chan, C.D. Duffy, B.
Gerland, S. Islam, M.W. Powner, J.D. Sutherland and J. Xu, Nature Chem.
2013 , 5, 383-389.
80 ‘Synthesis of Aldehydic Ribonucleotide and Amino Acid Precursors by
Photoredox Chemistry’ D.J. Ritson and J.D. Sutherland, Angew. Chem. Int.
Ed. 2013, 52, 5845-5847.
81 ‘Towards an Evolutionary Theory of the Origin of Life Based on Kinetics and
Thermodynamics’ R. Pascal, A. Pross and J.D. Sutherland, Open Biol. 2013,
3, 130156.
82 ‘Self-Assembly of Phosphate Amphiphiles in Mixtures of Prebiotically
Plausible Surfactants’ N.A. Albertsen, C.D. Duffy, J.D. Sutherland and P.-A.
Monnard, Astrobiology, 2014, 14, 462-472.
83
‘Solid-Phase Synthesis and Hybrization Behaviour of Partially 2/3-OAcetylated RNA Oligonucleotides’ J. Xu, C.D. Duffy, C.K.W. Chan and J.D.
Sutherland, J. Org. Chem. 2014, 79, 3311-3326.
84
‘Conversion of Biosynthetic Precursors of RNA to those of DNA by
Photoredox Chemistry’ D.J. Ritson and J.D. Sutherland, J. Mol. Evol. 2014,
78, 245-250.
85
‘Excited-state hydrogen atom abstraction initiates the photochemistry of -2deoxycytidine’ R. Szabla, J. Campos, J.E. Sponer, J. Sponer, R.W. Gora and
J.D. Sutherland, Chem. Sci. 2015, 6, 2035-2043.
86
‘Common origins of RNA, protein and lipid precursors in a cyanosulfidic
protometabolism’ B.H. Patel, C. Percivalle, D.J. Ritson, C.D. Duffy and J.D.
Sutherland, Nature Chem. 2015 , 7, 301-307.
87
‘The Origin of Life – Out of the Blue?’ J.D. Sutherland, Angew. Chem. Int. Ed.
2016, 55, 104-121.
Patents
1
Sutherland, John David; Bovenberg, Roelof Ary Lans; Van Der Laan, Jan
Metske. Deacetoxycephalosporin C synthetase analogs and their used
in an improved process for the production of semi-synthetic
cephalosporins from penicillin G. PCT Int. Appl. (1997), 21 pp.
CODEN: PIXXD2 WO 9720053 A2 19970605 CAN 127:77928 AN
1997:454069 CAPLUS
2
Blackburn, Jonathan Michael; Sutherland, John David; Samaddar, Mitali;
Mulder, Michelle Anne; Kozlowski, Roland Z. Methods for the preparation
of ordered arrays of full-length proteins tagged with affinity labels for
capture. PCT Int. Appl. (2001), 47 pp. CODEN: PIXXD2 WO
2001057198 A2 20010809 CAN 135:163331 AN 2001:582034 CAPLUS
3
Sutherland, John David. Apparatus for monitoring thermal events. PCT
Int. Appl. (2002), 31 pp. CODEN: PIXXD2 WO 2002011881 A1 20020214
CAN 136:169566 AN 2002:122861 CAPLUS
4
Kozlowski, Roland Zbignieiw; Blackburn, Jonathan Michael; Sutherland, John
David; Culliford, Steven John; Sutherland, Andrew James. Lipo- or
amphiphilic scintillators and their use in assays. PCT Int. Appl. (2002),
73 pp. CODEN: PIXXD2 WO 2002014290 A1 20020221 CAN
136:180152 AN 2002:142685 CAPLUS
5
Van den Berg, Marco Alexander; Bovenberg, Roelof Ary Lans; Raamsdonk,
Lourina Madeleine Leonie; Sutherland, John David; De Vroom, Erik; Vollinga,
Roeland Christiaan Roel. Preparation via biological and chemical
synthetic means and antibacterial activity of cephem compounds. PCT
Int. Appl. (2004), 53 pp. CODEN: PIXXD2 WO 2004106347 A1 20041209
CAN 142:56084 AN 2004:1059362 CAPLUS
6
Laan, Van Der Jan Metske; Sutherland, John David; Hensgens, Charles
Maria Hubert; Dijkstra, Bauke Wiepke. Sequence of modified 6aminopenicillanate acyltransferases for the production of different
lactam antibiotics. PCT Int. Appl. (2006), 60pp. CODEN: PIXXD2 WO
2006089951 A1 20060831 CAN 145:264233 AN 2006:887686 CAPLUS