Updated 8/22/13
Curriculum Vitae
Aziz Sancar
PERSONAL INFORMATION:
Business Address:
Department of Biochemistry and Biophysics
120 Mason Farm Road, Genetic Medicine 3073
University of North Carolina at Chapel Hill
CB# 7260
Chapel Hill, NC 27599-7260
Business Telephone:
(919) 962-0115
Home Address:
311 University Drive
Chapel Hill, NC 27516
Home Telephone:
(919) 933-9154
EDUCATION:
M.D.
M.S.
Ph.D.
1969
1975
1977
Istanbul Medical School, Istanbul
University of Texas at Dallas, Dallas, TX - Molecular Biology
University of Texas at Dallas, Dallas, TX - Molecular Biology
PROFESSIONAL EXPERIENCE -- EMPLOYMENT HISTORY:
1997-present Sarah Graham Kenan Professor
1988-1997
Professor of Biochemistry, University of North Carolina School of Medicine, Chapel Hill, NC
1982-1988
Associate Professor of Biochemistry (primary) and Radiology (secondary), Lineberger Cancer
Research Center, and Genetics Curriculum, School of Medicine, University of North Carolina
at Chapel Hill, Chapel Hill, NC
1977-1982
Research Associate, Yale School of Medicine, Department of Therapeutic Radiology, New
Haven, CT
1974-1977
Teaching Assistant, University of Texas at Dallas, Department of Molecular Biology, Dallas,
TX
1972-1973
Medical practice, Turkey
1971-1972
NATO Fellow, Johns Hopkins University, Department of Biochemistry Baltimore, MD
1969-1971
Medical practice, Turkey
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PROFESSIONAL SOCIETIES:
Member of American Society for Microbiology since January 1983.
Member of American Society of Biological Chemists since June 1983.
Member of American Chemical Society since January 1987.
Member of Lineberger Cancer Research Center since September 1984.
Member of Genetics Curriculum, UNC-CH since September 1985.
HONORS AND AWARDS:
1969
1965-1969
1971-1973
1984-1989
1990
1995
1995
1997
2001
2002
2004
2005
2005
2006
2006
2007
2009
M.D., Summa Cum Laude (first in class of 625)
NATO Scholarship
NATO Fellowship
Presidential Young Investigator Award from the NSF
American Society for Photobiology Research Award
Associate Fellow, Third World Academy of Sciences
Turkish Scientific Research Council Basic Science Award
Sarah Graham Kenan Professor
North Carolina Distinguished Chemist Award (ACS).
Miller Visiting Professor (Berkeley)
Fellow of the American Academy of Arts and Sciences
Fellow of the American Academy of Microbiology
Member of the National Academy of Sciences USA
Honorary Doctorate from Bilkent University, Turkey
Turkish Academy of Sciences
Turkish Koç Award
University of Texas at Dallas Distinguished Alumni Award
TEACHING RECORD:
Course director: Biochemistry 631 “Advanced Molecular Biology I” Fall Semester.
Lecturer in the same course (14 lectures).
GRANTS:
Active Support
a) National Institute of General Medical Sciences, R01-GM31082-28.
"Role of Cryptochrome in DNA Damage Responses and the Circadian Clock"
Aziz Sancar, Principal Investigator; 30% effort
Period of support: 7/1/10-6/30/14
Cost of entire project: $2,772,332
Annual direct cost: $334,391.00
b) National Institute of General Medical Sciences, R01-GM32833-29.
“DNA Excision Repair and DNA Damage Checkpoints”
Aziz Sancar, Principal Investigator; 30% effort
Cost of entire project: $2,457,644
Period of support: 4/1/12-3/31/16
Annual direct cost: $420,990.00
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c) Virginia Polytechnic Institute, DARPA award 5-44255
“Involvement of a Cryptochrome-Based Radical Pair Mechanism in Magnetoreception”
Aziz Sancar, Principal Investigator; 5% effort
Cost of entire project: $
Period of support: 10/1/11-9/30/14
Annual direct cost: $57,880.00
PROFESSIONAL SERVICE:
2000-present
2008-present
Editor: Journal of Biological Chemistry
Member: Biochemistry Search Committee
REFLECTIVE STATEMENT:
My areas of expertise are (1) cellular responses to DNA damage including DNA repair and DNA
damage checkpoints, and (2) molecular mechanism of the circadian clock. My lab has made significant
progress in both areas in the past 5 years. We plan to build upon these accomplishments and apply our
findings to translational research in cancer chemotherapy.
I continue to serve as the course director of Advanced Molecular Biology (BIOC631). In this course I
aim to teach students the latest developments in molecular biology/biochemistry, and teach the course in a
participatory manner so that the students learn to analyze research papers critically and with emphasis on
proper controls and quantitative analysis of the data.
BIBIOGRAPHY:
Publications In Refereed Journals:
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Sancar A, Rupert CS: Determination of plasmid molecular weights from ultraviolet sensitivities. Nature
272: 471-472, 1978.
Sancar A, Rupert CS: Correction of the map location for the phr gene of Escherichia coli K 12. Mutation
Res 51: 139-143, 1978.
Sancar A, Rupert CS: Cloning of the phr gene and amplification of photolyase in Escherichia coli. Gene 4:
294-308, 1978.
Sancar A, Rupert CS: Penicillin selection of Escherichia coli deoxyribonucleic acid repair mutants. J
Bacteriol 138: 779-782, 1979.
Sancar A, Hack AM, Rupp WD: Simple method for identification of plasmid-coded proteins. J Bacteriol
138: 692-693, 1979.
Sancar A, Rupp WD: Cloning of uvrA lexC and ssb genes of Escherichia coli. Biochem Biophys Res Comm
90: 123-129, 1979.
Sancar A, Rupp WD: Physical map of the recA gene. Proc Nat Acad Sci USA 76: 31443148, 1979.
Sancar A, Stachelek C, Konigsberg W, Rupp WD: Sequences of the recA gene and protein. Proc Nat Acad
Sci USA 77: 2611-2615, 1980.
Chase JW, Whittier RF, Auerbach J, Sancar A, Rupp WD: Amplification of single-strand DNA binding
protein in Escherichia coli. Nucl Acids Res 8: 3215-3227, 1980.
Sancar A, Wharton R, Seltzer S, Kacinski B, Clarke N, Rupp WD: Identification of the uvrA gene product.
J Molec Biol 148: 45-62, 1981.
Sancar A, Clarke N, Griswold J, Kennedy W, Rupp WD: Identification of the uvrB gene product. J Molec
Biol 148: 63-76, 1981.
Sancar A, Kacinski BM, Mott L, Rupp WD: Identification of the uvrC gene product. Proc Nat Acad Sci
USA 78: 5450-5454, 1981.
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Sancar A, Williams KR, Chase JW, Rupp WD: Sequences of the ssb gene and protein. Proc Nat Acad Sci
USA 78: 4274-4278, 1981.
Kacinski BM, Sancar A, Rupp WD: General Method for Purification of proteins encoded by cloned gene:
Isolation of the uvrA protein from radiolabelled maxicells. Nucl Acids Res 9: 4495-4508, 1981.
Sancar GB, Sancar A, Little JW, Rupp WD: The uvrB gene of E. coli has both LexArepressed and
LexA-independent promoters. Cell 28: 523-530, 1982.
Sancar A, Sancar GB, Little JW, Mount DW, Rupp WD: LexA protein inhibits transcription of the E. coli
uvra gene in vitro. Nature 298: 96-98, 1982.
Uhlin BE, Volkert MR, Clark AJ, Sancar A, Rupp WD: Nucleotide sequence of a recA operator mutation.
Mol Gen Genet 185: 251-254, 1982.
Rupp WD, Sancar A, Sancar GB: Properties and regulation of the uvrABC endonuclease. Biochimie 64:
595-598, 1982.
Schultz RA, Friedberg EC, Moses RE, Rupp WD, Sancar A, Sharma S: Use of an E. coli mutant strain
permit measurement of single-stranded apurinic-apyrimidinic endonuclease in crude extracts. J Bacteriol
154: 1459-1461, 1983.
Sancar A, Rupp WD: A novel repair enzyme: UvrABC excision nuclease of Escherichia coli cuts a DNA
strand on both sides of the damaged region. Cell 33: 249-260, 1983.
Sancar GB, Smith FW, Sancar A: Identification and amplification of the E. coli phr gene product. Nucl
Acids Res 11: 6667-6678, 1983.
Sancar A, Sancar GB: Escherichia coli DNA photolyase is a flavoprotein. J Molec Biol 172: 223-227,
1984.
Sancar A, Smith FW, Sancar GB: Purification of Escherichia coli DNA Photolyase. J Biol Chem 259:
6028-6032, 1984.
Sancar GB, Smith FW, Lorence MC, Rupert CS, Sancar A: Sequences of the Escherichia coli Photolyase
Gene and Protein. J Biol Chem 259: 6033-6038, 1984.
Jorns MS, Sancar GB, Sancar A: Identification of a Neutral Flavin Radical and Characterization of a
Second Chromophore in E. coli DNA Photolyase. Biochemistry 23: 2673-2679, 1984.
Sancar GB, Sancar A, Rupp WD: Sequences of the Escherichia Coli uvrC Gene Protein. Nucl Acids Res
12: 4593-4608, 1984.
Sancar A, Franklin KA, Sancar GB: Escherichia coli DNA Photolyase Stimulates UvrABC Excision
Nuclease In Vitro. Proc Natl Acad Sci USA 81: 7397-7401, 1984.
Markham BE, Harper JE, Mount DW, Sancar GB, Sancar A, Rupp WD, Kenyon CJ, Walker GC: Analysis
of MRNA Synthesis Following Induction of the Escherichia coli SOS System. J Molec Biol 178:
237-248, 1984.
Sancar GB, Smith FW, Sancar A: Binding of E. coli DNA Photolyase to UV-irradiated DNA. Biochemistry
24: 1849-1855, 1985.
Jorns MS, Sancar GB, Sancar A: Identification of Oligodeoxythymidylates as New Simple Substrate for E.
coli DNA Photolyase and Their Use in a Rapid Spectrophotometric Assay. Biochemistry 24: 1856-1861,
1985.
Brash DE, Franklin WA, Sancar GB, Sancar A, Haseltine WA: E. coli Photolyase Reverses Cyclobutane
Pyrimidine Dimers but not Pyrimidine-Pyrimidone(6-4) Photoproducts. J Biol Chem 260: 11438-11441,
1985.
Sancar A, Franklin KA, Sancar GB, Tang MS: Repair of Psoralen and Acetylaminofluorene DNA Adducts
by ABC Excinuclease. J Molec Biol 184: 725-734, 1985.
Thomas DC, Levy M, Sancar A: Amplification and Purification of UvrA, UvrB and UvrC Proteins of
Escherichia coli. J Biol Chem 260: 9875-9883, 1985.
Husain I, Chaney SG, Sancar A: Repair of cis-Platinum-Deoxyribronucleic Acid Adducts by ABC
Excinuclease in vivo and vitro. J Bacterial 163: 817-823, 1985.
Husain I, Van Houten B, Thomas DC, Abdel-Monem M, Sancar A: The effect of DNA Polymerase I and
Helicase II on the Turnover Rate of ABC Excinuclease. Proc Natl Acad Sci USA 82: 6774-6778, 1985.
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Beck DJ, Popoff S, Sancar A, Rupp WD: Reactions of the UvrABC excision nuclease with DNA damaged
by diammine dichloroplatinum(II). Nucl Acids Res l3: 7395-7412, 1985.
Mauldin SK, Husain I, Sancar A, Chaney SG: Effects of the Bidentate Malonate Ligand on the Utilization
and Cytotoxicity of Platinum Compounds in the Ll210 cell line. Cancer Research 46: 2876-2886, 1986.
Husain I, Van Houten B, Thomas DC, Sancar A: Sequences of the uvrA Gene and Protein Reveal two
potential ATP Binding Sites. J Biol Chem 261: 4895-4901, 1986.
Arikan E, Kulkarni MS, Thomas DC, Sancar A: Sequences of the E. coli uvrB Gene and Protein. Nucl
Acids Res 14: 2637-2650, 1986.
Van Houten B, Gamper H, Hearst JE, Sancar A: Construction of DNA substrates modified with psoralen at
a unique site and study of the action mechanism of ABC excinuclease on these uniformly modified
substrates. J Biol Chem 261: 14135-14141, 1986.
Van Houten B, Gamper H, Hearst JE, Holbrook SR, and Sancar A: Action Mechanism of ABC Excision
Nuclease on a DNA Substrate Containing a Psoralen Crosslink at a Defined Position. Proc Natl Acad Sci
USA 83: 8077-8083, 1986.
Thomas DC, Kunkel TA, Casna NJ, Ford JP, Sancar A: Activities and incision patterns of ABC
excinuclease on modified DNA containing single-base mismatches and extrahelical bases. J Biol Chem
261: 14496-14505, 1986.
Doolittle RF, Johnson MS, Husain I, Van Houten B, Thomas DC, Sancar A: Domainal evolution of a
prokaryotic DNA-repair protein: relationship to active transport proteins. Nature 323: 451-453, 1986.
Mauldin SK, Richard FA, Plescia M, Wyrick SD, Sancar A, and Chaney SG: Highperformance Liquid
Chromatographic Separation of Platinum Complexes Containing cis1,2-Diaminocyclohexane Carrier
Ligand. Analyt Biochem 157: 129-143, 1986.
Heelis PF and Sancar A: Photochemical properties of Escherichia coli DNA Photolyase: A Flash
Photolysis Study. Biochemistry 25: 8163-8166, 1986.
Sancar GB, Smith FW, Reid R, Payne G, Levy M, and Sancar A: Action Mechanism of E coli DNA
Photolyase I. Formation of the Enzyme-Substrate Complex. J Biol Chem 262: 478-485, 1987.
Jorns MS, Baldwin ET, Sancar GB and Sancar A: Action Mechanism of E. coli DNA Photolyase II. Role of
the Chromophores in catalysis. J Biol Chem 262: 486-491, 1987.
Sancar GB, Jorns MS, Payne G, Fluke DJ, Rupert CS and Sancar A: Action Mechanism of E. coli DNA
Photolyase III. Photolysis of the ES Complex and the Absolute Action Spectrum. J Biol Chem 262:
492-498, 1987.
Myles GM, Van Houten B, and Sancar A: Utilization of DNA Photolyase, Pyrimidine Dimer
Endonucleases, and Alkali Hydrolysis in the Analysis of Aberrant ABC Excinuclease lncisions Adjacent
to UV-Induced DNA Photoproducts. Nucleic Acids Res 15: 1227-1243, 1987.
Van Houten B and Sancar A: Repair of N-Methyl-N-nitro-nitrosoguanidine DNA Damage by ABC
Excision Nuclease. J Bacterial 169: 540-545, 1987.
Husain I and Sancar A: Binding of E. coli DNA Photolyase to Defined Substrate Containing a Single T<>T
Dimer. Nucleic Acids Res 15: 1109-1120, 1987.
Husain I and Sancar A: Photoreactivation in the phr Mutants of Escherichia coli K-12. J Bacteriol 169:
2367-2372, 1987.
Husain I, Sancar GB, Holbrook SR and Sancar A: Mechanism of Damage Recognition by E. coli DNA
Photolyase. J Biol Chem 262: 13188-13197, 1987.
Heelis PF, Payne GP and Sancar A: Photochemical Properties of Escherichia coli DNA Photolyase:
Selective Decomposition of the Second Chromophore. Biochemistry 26: 4634-4640, 1987.
Sancar A: DNA Repair In Vitro, Photobiochem. Photobiophys 11: 301-315, 1987.
Sancar GB and Sancar A: Structure and Function of DNA Photolyases. Trends in Biochem Sci 12:
259-261, 1987.
Van Houten B, Gamper H, Sancar A and Hearst JE: DNAse I footprint of ABC Excinuclease. J Biol Chem
262: 13180-13187, 1987.
Payne G, Heelis PF, Rohrs BR, Sancar A: The Active Form of DNA Photolyase Contains a Fully Reduced
Flavin and not a Flavin Radical both in vivo and in vitro. Biochemistry 26: 7121-7127, 1987.
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Orren DK, Sancar A: New Discoveries in the Enzymology of DNA Repair. Cancer Rev 7: 5-27, 1987.
Sancar A, Sancar GB: DNA Repair Enzymes. Annu Rev Biochem 57: 29-67, 1988.
Husain I, Carrier WL, Regan JD, Sancar A: Photoreactivation of Killing in E. coli K-12 phr Cells is not
caused by Pyrimidine Dimer Reversal. Photochem Photobiol 48: 233-234, 1988.
Husain I, Griffith J, and Sancar A: Thymine Dimers Bend DNA. Proc Natl Acad Sci USA 85: 2258-2262,
1988.
Johnson JL, Hamm-Alvarez S, Payne G, Sancar GB, Rajagopalan KV and Sancar A: Identification of the
Second chromophore of Escherichia coli and Yeast DNA Photolyasas 5,10-Methenyltetrahydrofolate.
Proc Natl Acad Sci USA 85: 2046-2050, 1988.
Thomas DC, Morton AG, Bohr VA, Sancar A: General Method for Quantifying Base Adducts in Specific
Mammalian Genes. Proc Natl Acad Sci USA 85: 3723-3727, 1988.
Cheng S, Van Houten B, Gamper H, Sancar A, Hearst JE: Use of Psoralen-modified oligonucleotides to
trap three-stranded RecA-DNA complexes and repair of these crosslinked complexes by ABC
Excinuclease. J Biol Chem 263: 11451-11460, 1988.
Selby CP, and Sancar A: ABC excinuclease incises both 5' and 3' to the CC-1065-DNA adduct and its
incision activity is stimulated by DNA helicase II and DNA polymerase 1. Biochemistry 27: 7184-7188,
1988.
Van Houten B, Gamper H, Hearst JE, Sancar A: Analysis of sequential steps of nucleotide excision repair
in Escherichia coli using synthetic substrates containing single psoralen adducts. J Biol Chem 263:
16553-16560, 1988.
Voigt JM, Van Houten B, Sancar A, Topal MD: Repair of 06-methylguanine by ABC excinuclease of
Escherichia coli in vitro. J Biol Chem 264: 5172-5176, 1989.
Hamm-Alvarez S, Sancar A, Rajagopalan KV: The role of the enzyme bound 5,1 0methenyltetrahydropteroylpolyglutamate in catalysis by Escherichia coli DNA photolyase. J Biol Chem
264: 9649-9656, 1989.
Kiener A, Husain I, Sancar A, Walsh C: Purification and properties of Methanobacterium
thermoautotrophicum DNA photolyase. J Biol Chem 264: 13880-13887, 1989.
Orren DK, Sancar A: The (A)BC excinuclease of E. coli has only the UvrB and UvrC subunits in the
incision complex. Proc Natl Acad Sci. USA 86: 5237-5241, 1989.
Sibghat-Ullah, Husain I, Carlton W, Sancar A: Human nucleotide excision repair in vitro: repair of
pyrimidine dimers, psoralen and cisplatin adducts by HeLa cell-free extract. Nucl Acids Res 17:
4471-4484, 1989.
Navaratnam S, Myles G, Strange R, Sancar A: Evidence from extended X-ray absorption fine structure and
site-specific mutagenesis for zinc fingers in UvrA protein of Escherichia coli. J Biol Chem 264:
16067-16071, 1989.
Thomas DC, Okumoto DS, Sancar A, Bohr VA: Preferential DNA repair of (6-4) photoproducts in the
DHFR gene of Chinese hamster ovary cells. J Biol Chem 264: 18005-18010, 1989.
Myles G, Sancar A: DNA Repair. Chem Res Toxicol 2: 197-226, 1989.
Payne NP, Sancar A: The LexA protein does not bind specifically to the two SOS-box like sequences
immediately 5' to the phr gene. Mutat Res 218:207-210, 1989.
Okamura T, Sancar A, Heelis P, Hirata Y, Mataga N: Doublet-Quartet Intersystem Crossing of Flavin
Radical in DNA Photolyase. J Am Chem Soc 111: 5967-5969, 1989.
Lin JJ, Sancar A: A New Mechanism for Repairing Oxidative Damage to DNA: (A)BC Excinuclease
Removes AP Sites and Thymine Glycols from DNA. Biochemistry 28: 7979-7984, 1989.
Witmer MR, Altmann E, Young H, Begley TP, Sancar A: Mechanistic studies on DNA photolyase-1.
Secondary deuterium isotope effects on the cleavage of 2'-deoxyuridine dinucleotide photodimers. J Am
Chem Soc 111: 9264-9265, 1989.
Selby CP, Sancar A: Molecular mechanisms of DNA repair inhibition by caffeine. Proc Nat Acad Sci USA
87: 3522-3525, 1990.
Page JD, Husain I, Sancar A, Chaney SG: Effect of diaminocyclohexane carrier ligand on platinum adduct
formation, repair, and lethality. Biochemistry 29: 1016-1024, 1990.
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Heelis PF, Okamura T, Sancar A: Excited state properties of E. coli DNA photolyase in the picosecond to
millisecond time scale. Biochemistry 29: 5694-5698, 1990.
Li YF, Sancar A: Active site of E coli DNA photolyase: mutations at trp 277 alter the selectivity of the
enzyme without affecting the quantum yield of photorepair. Biochemistry 29: 5698-5706, 1990.
Payne G, Wills M, Walsh C, Sancar A: Reconstitution of E. coli photolyase with flavins and flavin analogs.
Biochemistry 29: 5706-5711, 1990.
Sibghat-Ullah, Sancar A: Substrate overlap and functional competition between human nucleotide excision
repair and E. coli photolyase and (A)BC excision nuclease. Biochemistry 29: 5711-5718, 1990.
Payne G, Sancar A: Absolute action spectrum of E-FADH2 and E-FADH2-MTHF forms of Escherichia
coli DNA photolyase. Biochemistry 29: 7715-7727, 1990.
Sibghat-Ullah, Sancar A, Hearst JE: The repair patch of E. coli (A)BC excinuclease. Nucleic Acids Res 18:
5051-5053, 1990.
Hamm-Alvarez SF, Sancar A, Rajagopalan KV: The presence and distribution of reduced folates in E. coli
dihydrofolate reductase mutants. J Biol Chem 265: 9850-9856, 1990.
Orren DK, Sancar A: Formation and enzymatic properties of the UvrB.DNA complex. J Biol Chem 265:
15796-15803, 1990.
Hamm-Alvarez SF, Sancar A, Rajagopalan KV: The folate cofactor of Escherichia coli DNA photolyase
acts catalytically. J Biol Chem 265: 18656-18662, 1990.
Selby CP, Sancar A: Transcription preferentially inhibits nucleotide excision repair of the template DNA
strand in vitro. J Biol Chem 265: 21330-21336, 1990.
Lin JJ, Sancar A: Reconstitution of nucleotide excision nuclease with UvrA and UvrB proteins from
Escherichia coli and UvrC protein from Bacillus subtins. J Biol Chem 265: 21337-21341, 1990.
Selby CP, Sancar A: Structure and Function of (A)BC excinuclease. Mutat Res 236: 203-211, 1990.
Cheng S, Sancar A, Hearst JE: RecA-dependent incision of psoralen-crosslinked DNA by (A)BC
excinuclease. Nucl Acids Res 19: 657-663, 1991.
Bertrand-Burggraf E, Selby CP, Hearst JE, Sancar A: Identification of the different intermediates in the
interaction of (A)BC excinuclease with its substrate by DNase I footprinting on two uniquely modified
oligonucleotides. J Mol Biol 218: 27-36, 1991.
Myles GM, Hearst JE, Sancar A: Site-specific mutagenesis of conserved residues within Walker A and B
sequences of E coli UvrA protein. Biochemistry 30: 3824-3834, 1991.
Myles GM, Sancar A: Isolation and characterization of functional domains of UvrA. Biochemistry 30:
3834-3840, 1991.
Selby CP, Sancar A: Noncovalent drug-DNA binding interaction that inhibit and stimulate (A)BC
excinuclease. Biochemistry 30: 3841-3849, 1991.
Li YF, Heelis PF, Sancar A: Active site of DNA photolyase: Trp 306 is the intrinsic H-atom donor essential
for flavin radical photoreduction and DNA repair in vitro. Biochemistry 30: 6322-6329, 1991.
Kim S-T, Sancar A: Effect of base, pentose and phosphodiester backbone structures on binding and repair
of pyrimidine dimers by E. coli DNA photolyase. Biochemistry 30: 8623-8630, 1991.
Kim S-T, Heelis PF, Okamura T, Hirata Y, Mataga N, Sancar A: Determination of rates and yields of
interchromophore energy transfer and intermolecular electron transfer in E. coli photolyase by
time-resolved fluorescence and absorption spectroscopy. Biochemistry 30: 11262-11270, 1991.
Okamura T, Sancar A, Heelis PF, Begley TP, Hirata Y, Mataga N: Picosecond laser photolysis studies on
the photorepair of pyrimidine dimers by DNA photolyase. J Am Chem Soc 113: 3143-3145, 1991.
Jones JC, Zhen W, Reed E, Parker RJ, Sancar A, Bohr VA: Preferential DNA repair of cisplatin adducts
and crosslinks in an active gene in CHO cells. J Biol Chem 266: 71017107, 1991.
Li YF, Sancar A: Cloning, sequencing, expression and characterization of DNA photolyase from
Salmonella typhimurium. Nucleic Acids Res 18: 4885-4890, 1991.
Reardon JT, Spielmann P, Huang JC, Sastry S, Sancar A, Hearst JE: Removal of psoralen monoadducts
and crosslinks by human cell free extracts. Nucleic Acids Res 18: 4623-4629, 1991.
Lin JJ, Sancar A: The carboxy terminal half of UvrC protein is sufficient to reconstitute (A)BC
excinculease. Proc Natl Acad Sci USA 88: 6824-6828, 1991.
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107. Selby CP, Sancar A: Gene- and strand specific repair in vitro: partial purification of a transription-repair
coupling factor. Proc Natl Acad Sci USA 88: 8232-8236, 1991.
108. Selby CP, Witkin EM, Sancar A: E. coli mfd mutant deficient in "Mutation Frequency Decline" lacks
strand-specific repair: in vitro complementation with purified coupling factor. Proc Natl Acad Sci USA
88: 11574-11578, 1991.
109. Kim ST, Li YF, Sancar A: The third chromophore of DNA photolyase: trp277 of E. coli DNA photolyase
repairs thymine dimers by direct electron transfer. Proc Natl Acad Sci USA 89: 900-904, 1992.
110. Huang JC, Svoboda DL, Reardon JT, Sancar A: Human nucleotide excision nuclease removes thymine
dimers by hydrolyzing the 22nd phosphodiester bond 5' and the 6th phosphodiester bond 3' to the
photodimer. Proc Natl Acad Sci USA 89: 3664-3668, 1992.
111. Orren DK, Selby CP, Hearst JE, Sancar A: Post-incision steps of nucleotide excision repair in E. coli:
disassembly of the UvrBC-DNA complex by helicase II and DNA polymerase I. J Biol Chem 267:
780-788, 1992.
112. Malhotra K, Baer M, Li YF, Sancar GB, Sancar A: Identification of chromophore binding domains of yeast
DNA photolyase. J Biol Chem 267: 2909-2914, 1992.
113. Nichols AF, Schmidt WJ, Chaney SG, Sancar A: Limitations of the in vitro repair synthesis assay for
probing the role of DNA repair in platinum resistance. Chem Biol Interactions 81: 223-231, 1992.
114. Nichols AF, Sancar A: Purification of PCNA as a nucleotide excision repair protein. Nucleic Acids Res 20:
2441-2446, 1992.
115. Shi Q, Thresher R, Sancar A, Griffith J: An electron microscopic study of (A)BC excinuclease. J Mol Biol
226: 425-432, 1992.
116. Heelis PF, Deeble DJ, Kim S-T, Sancar A: Splitting of cis-syn cyclobutane thyminethymine dimers by
radiolysis and its relevance to enzymatic photoreactivation. Int J Radiat Biol 62: 137-143, 1992.
117. Malhotra K, Kim ST, Walsh CT, Sancar A: Roles of FAD and 8-hydroxy-5-deazaflavin chromophores in
photoreactivation by Anacystis nidulans DNA photolyase. J Biol Chem 267: 15406-15411, 1992.
118. Lin JJ, Sancar A: (A)BC excinuclease: the Escherichia cot nucleotide excision repair enzyme. Molec
Microbial 6: 2219-2224, 1992.
119. Lin JJ, Sancar A: Active site of (A)BC excinuclease. I. Evidence for 5' incision by UvrC through a catalytic
site involving Asp 399, Asp 438, Asp 466, and His 538 residues. J Biol Chem 267: 17688-17692, 1992.
120. Lin JJ, Phillips AM, Hearst JE, Sancar A: Active site of (A)BC excinuclease. II. Binding, bending, and
catalysis mutants of UvrB reveal a direct role in 3' and an indirect role in 5' incision. J Biol Chem 267:
17693-17700, 1992.
121. Kim ST, Sancar A, Essenmacher C, Babcock G: Evidence from photoinduced EPR for a radical
intermediate during photolysis of cyclobutane thymine dimer by DNA photolyase. J Am Chem Soc 114:
442-443, 1992.
122. Sibghat-Ullah, Sancar A: In vitro characterization of repair synthesis initiated by T4 endonuclease V on a
synthetic DNA substrate. Indian J Biochem and Biophys 29: 227230, 1992.
123. Heelis PF, Sancar A, Okamura T: Excited quartet states in DNA photolyase. J Photochem Photobiol 16:
387-390, 1992.
124. Kim ST, Heelis PF, Sancar A: Energy transfer (Deazaflavin  FADH2) and electron transfer (FADH2 
T<>T) kinetics in Anacystis nidulans photolyase. Biochemistry 31: 11244-11248, 1992.
125. Sastry SS, Spielmann HP, Hoang OS, Phillips AM, Sancar A, Hearst JE: Laser-induced protein-DNA
crosslink via psoralen furanside monoadducts. Biochemistry 32: 5526-5538, 1993.
126. Svoboda DL, Taylor JS, Hearst JE, Sancar A: DNA repair by eukaryotic nucleotide excision nuclease:
removal of thymine dimer and psoralen monoadduct by HeLa cell free extract and of thymine dimer by
Xenopus laevis Oocytes. J Biol Chem 268: 1931-1936, 1993.
127. Essenmacher C, Kim ST, Atamian M, Babcock GT, Sancar A: Tryptophan radical formation in DNA
photolyase: electron-spin polarization arising from photoexcitation of a doublet ground state. J Am Chem
Soc 115: 1602-1603, 1993.
128. Sancar A, Hearst JE: Molecular matchmakers. Science 259: 1415-1420, 1993.
129. Selby CP, Sancar A: Molecular Mechanism of transcription-repair coupling. Science 260: 53-58, 1993.
8
130. Li YF, Kim S-T, Sancar A: Evidence for lack of DNA photoreactivating enzyme in humans. Proc Natl
Acad Sci USA 90: 4389-4393, 1993.
131. Svoboda DL, Smith CA, Taylor J-S, Sancar A: Effect of sequence, adduct type, and opposing lesions on
the binding and repair of UV photodamage by DNA photolyase and (A)BC excinuclease. J Biol Chem
268: 10694-10700, 1993.
132. Park H-W, Sancar A, Deisenhofer J: Crystallization and preliminary crystallographic analysis of
Escherichia coli DNA photolyase. J Mol Biol 231: 1122-1125, 1993.
133. Kim S-T, Malhotra K, Smith CA, Taylor J-S, Sancar A: DNA photolyase repairs the trans,syn cyclobutane
thymine dimer. Biochemistry 32: 7065-7068, 1993.
134. Kim ST, Sancar A, Essenmacher C, Babcock GT: Time-resolved EPR studies with DNA photolyase:
excited state FADH° abstracts an electron from trp306 to generate FADH- the catalytically active form of
the cofactor. Proc Natl Acad Sci USA 90: 8023-8027, 1993.
135. Reardon JT, Thompson LH, Sancar A: Excision repair in man and the molecular basis of xeroderma
pigmentosum syndrome. Cold Spring Harbor Symp Ouant Biol 58: 605-617, 1993.
136. Reardon JT, Nichols AF, Keeney S, Smith CA, Taylor J-S, Linn S, Sancar A: Comparative analysis of
binding of human DDB(XPE) and E. coli UvrA damage recognition proteins to the major UV
photoproducts: T[c,s]T, T[t,s]T, T[6,4]T, and T[Dew]T. J Biol Chem 268: 21301-21308, 1993.
137. Park CH, Sancar A: Reconstitution of mammalian excision repair activity with mutant cellfree extracts and
XPAC and ERCC1 proteins expressed in E. coli. Nucleic Acids Res. 21: 5110-5116, 1993.
138. Selby CP, Sancar A: Transcription-repair coupling and mutation frequency decline. J Bacteriol 175:
7509-7514, 1993.
139. Kim ST, Sancar A: Photochemistry, photophysics and mechanism of pyrimidine dimer repair by DNA
photolyase. Photochem Photobiol 57: 895-904, 1993.
140. Sancar A, Tang MS: Nucleotide excision repair. Photochem Photobiol 57: 905-921, 1993.
141. Heelis PF, Kim ST, Okamura T, Sancar A: The photorepair of pyrimidine dimers by DNA photolyase and
model systems. J Photochem Photobiol 17: 219-228, 1993.
142. Sancar A: Structure and function of DNA photolyase. Biochemistry 33: 2-9, 1994.
143. Kim ST, Malhotra K, Smith CA, Taylor J-S, Sancar A: Characterization of (6-4) photoproduct DNA
photolyase. J Biol Chem 269: 8535-8540, 1994.
144. Kim ST, Volk M, Rousseau G, Heelis PF, Sancar A, Michel-Beyerle ME: Laser flash photolysis on an
intermediate in the repair of pyrimidine dimers by DNA photolyase. J Am Chem Soc 116: 3115-3116,
1994.
145. Drapkin R, Sancar A, and Reinberg D: Where transcription meets repair. Cell 77: 9-12, 1994.
146. Drapkin R, Reardon J, Ansari A, Huang JC, Zawel L, Ahn K, Sancar A, Reinberg D: Dual role of TFIIH in
DNA excision repair and transcription by RNA polymerase II. Nature 368: 769-772, 1994.
147. Selby CP, Sancar A: Mechanisms of transcription-repair coupling and mutation frequency decline.
Microbial Rev 58: 317-329, 1994.
148. Park CH, Sancar A: Formation of a ternary complex between human XPA, ERCC1 and ERCC4(XPF)
excision repair proteins. Proc Natl Acad Sci USA 91: 5017-5021, 1994.
149. Thompson L, Brookman KW, Weber CA, Salazar EP, Reardon JT, Sancar A, Deng Z, Siciliano MJ:
Molecular cloning of the human nucleotide-excision-repair gene ERCC4. Proc Natl Acad Sci USA 91:
6855-6859, 1994.
150. Hsu DS, Takahashi M, Delagoutte E, Bertrand-Burggraf E, Wang YH, Norden B, Fuchs RPP, Griffith J,
Sancar A: Flow linear dichroism and electron microscopic analysis of protein-DNA complexes of a
mutant UvrB protein which binds to but cannot kink DNA. J Molec Biol 241: 645-650, 1994.
151. Huang JC, Sancar A: Determination of minimum size substrate for human excinuclease. J Biol Chem 269:
19034-19040, 1994.
152. Malhotra K, Kim ST, Sancar A: Characterization of a medium wavelength type DNA photolyase:
purification and properties of photolyase from Bacillus firmus. Biochemistry 33: 8712-8718, 1994.
9
153. Huang JC, Zamble DB, Reardon JT, Lippard SJ, Sancar A: HMG-domain proteins specifically inhibit the
repair of the major DNA adduct of the anticancer drug cisplatin by human excision nuclease. Proc Natl
Acad Sci USA 91: 10394-10398, 1994.
154. Huang JC, Hsu DS, Kazantsev A, Sancar A: Substrate spectrum of human excinuclease: repair of abasic
sites, methylated bases, mismatches and bulky adducts. Proc Natl Acad Sci USA 91: 12213-12217, 1994.
155. Mu D, Bertrand-Burggraf E, Huang JC, Fuchs RPP, Sancar A: Human and E. coli excinucleases are
affected differently by the sequence context of the acetylaminofluorene-guanine adduct. Nucleic Acids
Res 22: 4869-4871, 1994.
156. Sancar A: Mechanisms of excision repair. Science 266: 1954-1956, 1994.
157. Mu D, Park CH, Matsunaga T, Hsu DS, Reardon JT, Sancar A: Reconstitution of human DNA repair
excision nuclease in a highly defined system. J Biol Chem 270: 2415-2418, 1995.
158. Selby CP, Sancar A: Structure and function of transcription-repair coupling factor I. Structural domains
and binding properties. J Biol Chem 270: 4882-4889, 1995.
159. Selby CP, Sancar A: Structure and function of transcription-repair coupling factor II. Catalytic properties.
J Biol Chem 270: 4890-4895, 1995.
160. Park CH, Mu D, Reardon JT, Sancar A: The general transcription repair factor TFIIH is recruited to the
excision repair complex by the XPA protein independent of the TFIIE transcription factor. J Biol Chem
270: 4896-4902, 1995.
161. Hsu DS, Kim ST, Sun Q, Sancar A: Structure and function of the UvrB protein. J Biol Chem 270:
8319-8327, 1995.
162. Kim ST, Sancar A: Photorepair of non-adjacent pyrimidine dimers by DNA photolyase. Photochem
Photobiol 61: 171-174, 1995.
163. Pan ZQ, Park CH, Amin AA, Hurwitz J, Sancar A: Phosphorylated and unphosphorylated forms of human
single-stranded DNA-binding protein are equally active in simian virus 40 DNA replication and in
nucleotide excision repair. Proc Natl Acad Sci USA 92: 4636-4640, 1995.
164. Malhotra K, Kim ST, Batschauer A, Dawut L, Sancar A: Putative blue-light photoreceptors from
Arabidopsis thaliana and Sinapis alba with a high degree of sequence homology to DNA photolyase
contain the two photolyase cofactors but lack DNA repair activity. Biochemistry 34: 6892-6899, 1995.
165. Park HW, Kim ST, Sancar A, Deisenhofer J: Crystal structure of DNA photolyase from Escherichia coli.
Science 268: 1866-1872, 1995.
166. Matsunaga T, Mu D, Park CH, Reardon JT, Sancar A: Human DNA repair excision nuclease: analysis of the
roles of the subunits involved in dual incisions by using anti-XPG and anti-ERCC1 antibodies. J Biol
Chem 270: 20862-20869, 1995.
167. Sancar A: Excision repair in mammalian cells. J Biol Chem 270: 15915-15918, 1995.
168. Pan ZQ, Reardon JT, Li L, Flores-Rozas H, Legerski R, Sancar A, Hurwitz J: Inhibition of nucleotide
excision repair by the cyclin-dependent kinase inhibitor p2l. J Biol Chem 270: 22008-22016, 1995.
169. Park CH, Bessho T, Matsunaga T, Sancar A: Purification and characterization of the XPF-ERCC1 complex
of human DNA repair excision nuclease. J Biol Chem 270: 22657-22660, 1995.
170. Kazantsev A, Sancar A: Does the p53 up-regulated Gadd45 protein have a role in excision repair? Science
270: 1003-1004, 1995.
171. Özer Z, Reardon JT, Hsu D, Malhotra K, Sancar A: The other function of DNA photolyase: stimulation of
excision repair of chemical damage to DNA. Biochemistry 34: 15886-15889, 1995.
172. Kim ST, Heelis PF, Sancar A: The role of tryptophans in substrate recognition and catalysis by DNA
photolyase. Methods Enzymol 258: 319-343, 1995.
173. Sancar A: DNA repair in humans. Annu Rev Genet 29: 69-105, 1995.
174. Sancar A: DNA excision repair. Annu Rev Biochem 65: 43-81, 1996.
175. Mu D, Hsu DS, Sancar A: Reaction mechanism of human DNA repair excision nuclease. J Biol Chem 271:
8285-8294, 1996.
176. Matsunaga T, Park CH, Bessho T, Mu D, Sancar A: Replication protein A confers structure-specific
endonuclease activities to the XPF-ERCC1 and XPG subunits of human DNA repair excision nuclease. J
Biol Chem 271: 11047-11050, 1996.
10
177. Sancar A: No “End of History” for photolyases. Science 272: 48-49, 1996.
178. Kim ST, Malhotra K, Taylor JS, Sancar A: Purification and partial characterization of (6-4) photoproduct
DNA photolyase from Xenopus laevis. Photochem Photobiol 63: 292-295, 1996.
179. Kazantsev A, Mu D, Nichols A, Zhao X, Linn S, Sancar A: Functional complementation of xeroderma
pigmentosum complementation group E by replication protein A in an in vitro system. Proc Natl Acad Sci
USA 93: 4698-4702, 1996.
180. Reardon JT, Ge H, Gibbs E, Sancar A, Hurwitz J, Pan ZQ: Isolation and characterization of two human
transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH*. Proc Natl Acad Sci USA
93: 6482-6487, 1996.
181. Duckett DR, Drummond JT, Murchie AIH, Reardon JT, Sancar A, Lilley DMJ, Modrich P: Human MutS
recognizes damaged DNA base pairs containing O6-methylguanine, O6-methylthymine or
cisplatin-d(GpG) adduct. Proc Natl Acad Sci USA 93: 6443-6447, 1996.
182. Zamble DB, Mu D, Reardon JT, Sancar A, Lippard SJ: Repair of cisplatin-DNA adducts by the mammalian
excision nuclease. Biochemistry 35: 10004-10013, 1996.
183. Kim ST, Malhotra K, Ryo H, Sancar A, Todo T: Purification and characterization of Drosophila
melanogaster photolyase. Mutation Res 363: 97-104, 1996.
184. Reardon JT, Mu D, Sancar A: Overproduction, purification, and characterization of the XPC subunit of the
human DNA repair excision nuclease. J Biol Chem 271: 19451-19456, 1996.
185. Chaney SG, Sancar A: DNA repair-enzymatic mechanisms and relevance to drug response. J Natl Cancer
Inst. 88: 1346-1360, 1996.
186. Brookman KW, Lamerdin JE, Thelen MP, Hwang M, Reardon JT, Sancar A, Zhou ZQ, Walter CA, Parris
CN, Thompson LH: ERCC4 (XPF) encodes a human nucleotide excision repair protein with eukaryotic
recombination homologs. Molec Cell Biol 16: 6553-6562, 1996.
187. Hsu DS, Zhao X, Zhao S, Kazantsev A, Wang RP, Todo T, Wei YF, Sancar A: Putative human blue-light
photoreceptors hCRY1 and hCRY2 are flavoproteins. Biochemistry 35: 13871-13877, 1996.
188. Mu D, Sancar A: DNA excision repair assays. Progr Nucleic Acid Res Molec Biol 56: 63-81, 1997.
189. Mu D, Tursun M, Duckett DR, Drummond JT, Modrich P, Sancar A: Recognition and repair of compound
DNA lesions (base damage and mismatch) by human mismatch repair and excision repair systems. Molec
Cell Biol 17: 760-769, 1997.
190. Selby CP, Sancar A: Human transcription-repair coupling factor CSB/ERCC6 is a DNA-stimulated ATPase
but is not a helicase and does not disrupt the ternary transcription complex of stalled RNA polymerase II.
J Biol Chem 272: 1885-1890, 1997.
191. Bessho T, Sancar A, Thompson LH, Thelen MP: Reconstitution of human excision nuclease with
recombinant XPF-ERCC1 complex. J Biol Chem 272: 3833-3837, 1997.
192. Selby CP, Drapkin R, Reinberg D, Sancar A: RNA polymerase II stalled at a thymine dimer: footprint and
effect on excision repair. Nucleic Acids Res 25: 787-793, 1997.
193. Reardon JT, Thompson LH, Sancar A: Rodent UV sensitive mutant cell lines in complementation groups
6-10 have normal general excision repair activity. Nucleic Acids Res 25: 1015-1021 (cover), 1997.
194. Mu D, Sancar A: Model for XPC-independent transcription-coupled repair of pyrimidine dimers in humans.
J Biol Chem 272: 7570-7573, 1997.
195. Wakasugi M, Reardon JT, Sancar A: The non-catalytic function of XPG protein during dual incision in
human nucleotide excision repair. J Biol Chem 272: 16030-16034, 1997.
196. Reardon JT, Bessho T, Kung HC, Bolton PH, Sancar A: In vitro repair of oxidative DNA damage by human
nucleotide excision repair system: possible explanation for neurodegeneration in xeroderma pigmentosum
patients. Proc Natl Acad Sci USA 94: 9436-9468, 1997.
197. Selby CP, Sancar, A: Cockayne syndrome group B protein enhances elongation by RNA polymerase II.
Proc Natl Acad Sci USA 94: 11205-11209, 1997.
198. Perelman B, Dafni N, Naiman T, Eli D, Yaakov M, Feng TLY, Sinha S, Weber G, Khodaei S, Sancar A,
Dotan I, Canaani D: Molecular cloning of a novel human gene encoding a 63-kDa protein and its
sublocalization within the 11q13 Locus. Genomics 41: 397-405, 1997.
11
199. Zhao S, Sancar A: Human blue-light photoreceptor hCRY2 specifically interacts with protein
Serine/Threonine phosphatase 5(PP5) and modulates its activity. Photochem Photobiol 66: 727-731,
1997.
200. Bessho T, Mu D, Sancar A: Initiation of DNA interstrand crosslink repair in humans: The nucleotide
excision repair system makes dual incisions 5 to the crosslinked base and removes a 22-28
nucleotide-long damage-free dtrand. Molec Cell Biol 17: 6822-6830, 1997.
201. Zhao X, Liu J, Hsu DS, Zhao S, Taylor J-S, Sancar A: Reaction mechanism of (6-4) Photolyase. J Biol
Chem 272: 32580-32590, 1997.
202. Mu D, Wakasugi M, Hsu DS, Sancar A: Characterization of reaction intermediates of human excision repair
nuclease. J Biol Chem 272: 28971-28979, 1997.
203. Langenbacher T, Zhao X, Bieser G, Heelis PF, Sancar A, Michel-Beyerle ME: Substrate and Temperature
dependence of DNA-photolyase repair activity examined with ultrafast spectroscopy. J Am Chem Soc
119: 10532-10536, 1997.
204. Miyamoto Y, Sancar A: Vitamin B2-based blue-light photoreceptors in the retinohypothalamic tract as the
photoactive pigments for setting the circadian clock in mammals. Proc Natl Acad Sci USA 95: 6097-6102,
1998.
205. Wakasugi M, Sancar A: Assembly, subunit composition, and footprint of human DNA repair excision
nuclease. Proc Natl Acad Sci USA 95: 6669-6674, 1998.
206. Kazantsev A, Bullock SK, Sancar A, Cordeiro-Stone M: Generation and characterization of an imortal cell
line of xeroderma pigmentosum group E. Mutation Res 407: 55-65, 1998.
207. Khan SG, Levy HL, Legerski R, Quackenbush E, Reardon JT, Emmert S, Sancar, A, Lei, L, Schneider TD,
Cleaver JE, Kraemer KH: Xeroderma pigmentosum group C splice mutation associated with autism and
hypoglycinemia. J Invest Dermatol 111: 791-796, 1998.
208. Ögrünç M, Becker DF, Ragsdale SW, Sancar A: Nucleotide excision repair in the third kingdom. J
Bacteriol 180: 5796-5798, 1998.
209. Thresher RJ, Vitaterna MH, Miyamoto Y, Kazantsev A, Hsu DS, Petit C, Selby CP, Dawut L, Smithies O,
Takahashi JS, Sancar A: Role of mouse cryptochrome blue-light photoreceptor in circadian
photoresponses. Science 282: 1490-1494, 1998.
210. Selby CP and Sancar A: A third member of the photolyase/blue-light photoreceptor family in Drosophila
putative circation photoreceptor. Photochem Photobiol 69: 105-107, 1999.
211. Gindt YM, Vollenbroek E, Westphal K, Sackett H, Sancar A, Babcock GT: The origin of the transient EPR
Signal in DNA photolyase. Biochemistry 38: 3857-3866, 1999.
212. Kay CWM, Feicht R, Schulz K, Sadewater P, Sancar A, Bacher A, Möbius K, Richter G, Weber S: EPR,
ENDOR, and TRIPLE resonance spectroscopy on the neutral flavin radical in E. coli DNA photolyase.
Biochemistry 38: 16740-16748, 1999.
213. Sancar A: Excision repair invades the territory of mismatch repair. Nature Genetics 21: 247-249, 1999.
214. Petit C, Sancar A: Nucleotide excision repair: from E. coli to man. Biochimie 81: 15-25, 1999.
215. Wakasugi M, Sancar A: Order of assembly of human DNA repair excision nuclease. J. Biol. Chem 274:
18757-18768, 1999.
216. Reardon JT, Vaisman A, Chaney SG, and Sancar A: Efficient nucleotide excision repair of cisplatin,
oxaliplatin and JM216 platinum intrastrand DNA diadducts. Cancer Res. 59: 3968-3971, 1999.
217. Selby CP and Sancar A: A third member of the photolyase/blue-light photoreceptor family in Drosophila
putative circation photoreceptor. Photochem Photobiol 69: 105-107, 1999.
218. Gindt YM, Vollenbroek E, Westphal K, Sackett H, Sancar A, Babcock GT: The origin of the transient EPR
Signal in DNA photolyase. Biochemistry 38: 3857-3866, 1999.
219. Sancar A: Excision repair invades the territory of mismatch repair. Nature Genetics 21: 247-249, 1999.
220. Hara R., Selby CP, Liu M, Price DH, and Sancar A: Human transcription release factor 2 (HuF2) dissociates
RNA polymerases I and II stalled at a cyclobutane thymine dimer. J. Biol. Chem. 274: 24779-24786,
1999.
221. Miyamoto Y and Sancar A: Circadian regulation of the cryptochrome genes in the mouse. Molec. Brain
Res. 71: 248-253, 1999.
12
222. Vitaterna MH, Selby CP, Todo T, Niwa H, Thompson C, Fruechte EM, Hitomi K, Thresher RJ, Ishikawa T,
Miyazaki J, Takahashi JS, and Sancar A: Differential regulation of mammalian Period genes and
circadian rhythmicity by Cryptochrome 1 and 2. Proc. Natl. Acad. Sci. USA. 96: 12114-12119, 1999.
223. Petit C, Sancar A: From DNA photolyases to photoreceptors regulating the biological clocks Med. Sci. 12:
1411-1418, 1999.
224. Mu D, Bessho T, Nechev LV, Chen DJ, Harris TM, Hearst JE, Sancar A: DNA interstrand cross-links
induce futile repair synthesis in mammalian cell extracts. Mol. Cell. Biol. 20: 2446-2454, 2000.
225. Bessho T, Sancar A: Human DNA damage checkpoint protein hRAD9 is a 3' to 5' exonuclease. J. Biol.
Chem. 275: 7451-7454, 2000.
226. Shibutani S, Reardon JT, Suzuki N, Sancar A: Excision of tamoxifen-DNA adducts by the human
nucleotide excision repair system. Cancer Res. 60: 2607-2610, 2000.
227. Hara R, Mo J, Sancar A. DNA damage in nucleosome core is refractory to repair by human excision
nuclease. Molec. and Cell. Biol. 20: 9173-9181, 2000.
228. Selby C, Thompson C, Therese SM, Van Gelder RN, Sancar A. Functional redundancy of cryptochromes
and classical photoreceptors for nonvisual ocular photoreception in mice. Proc. Natl. Acad. Sci. USA 97:
14697-14702, 2000.
229. Sancar A, Thompson CL, Thresher RJ, Araujo F, Mo J, Ozgur S, Vagas E, Dawut L, Selby CP.
Photolyase/cryptochrome family blue-light photoreceptors use light energy to repair DNA or set the
circadian clock. Cold Spring Harb. Symp. Quant. Biol. 65: 157-171, 2000.
230. Sancar A. Cryptochrome: the second photoactive pigment in the eye and its role in circadian photoreception.
Annu. Rev. Biochem. 69: 31-67, 2000.
231. Branum ME, Reardon JT, Sancar A. DNA repair excision nuclease attacks undamaged DNA: A potential
source of spontaneous mutations. J.Biol.Chem. 276: 25421-25426, 2001.
232. George JW, Salazar EP, Vreeswijk MPG, Lamerdin JE, Reardon JT, Zdzienicka MZ, Sancar A,
Kadkhodayan S, Tebbs RS, Mullenders LHF, Thompson LH. Restoration of nucleotide excision repair in
a helicase-deficient XPD mutant from intragenic suppression by a trichothiodystrophy mutation. Molec.
Cell. Biol. 21: 7355-7365, 2001.
233. Lindsey-Boltz LA, Bermudez VP, Hurwitz J, Sancar A. Purification and characterization of human DNA
damage checkpoint Rad complexes. Proc. Natl. Acad. Sci. USA 98: 11236-11241, 2001.
234. Thompson CL, Blaner WS, Van Gelder RN, Lai K, Quadro L, Colantuoni V, Gottesman ME, Sancar A:
Preservation of light-signaling to the suprachiasmatic nucleus in vitamin A-deficient mice. Proc. Natl.
Acad. Sci. USA 98 : 11708-11713, 2001.
235. Wakasugi M, Kawashima A, Moriaka H, Linn S, Sancar A, Mori T, Nikaido O, Matsunaga T: DDB
accumulates at DNA damage sites immediately after UV irradiation and directly stimulates nucleotide
excison repair. J. Biol. Chem. 227: 1634-1640, 2002.
236. Griffith JD, Lindsey-Boltz LA, Sancar A. Structures of the human Rad17-Replication Factor C and
checkpoint 9-1-1 complexes visualized by glycerol spray/low voltage microscopy. J. Biol. Chem. 227:
15233-15236, 2002. (cover)
237. Unsal-Kacmaz K, Makhov AM, Griffith JD, Sancar A. Preferential binding of ATR protein to
UV-damaged DNA. Proc. Natl. Acad. Sci. USA 99: 6673-6678, 2002.
238. Cermakian N, Pando MP, Thompson CL, Pinchak AB, Selby CP, Gutierrez L, Wells DE, Cahill GM,
Sancar A, Sassone-Corsi P. Light induction of a vertebrate clock gene involves signaling through
blue-light receptors and MAP kinases. Curr Biol 12: 844-848, 2002.
239. Reardon JT, Sancar A. Molecular anatomy of the human excision nuclease assembled at sites of DNA
damage. Mol.Cell Biol. 22: 5938-5945, 2002.
240. Hara R, Sancar A. The SWI/SNF Chromatin-remodeling factor stimulates repair by human excision
nuclease in the mononucleosome core particle. Mol. Cell Biol. 22: 6779-6787, 2002.
241. Thompson CL, Sancar A. Photolyase/cryptochrome blue-light photoreceptors use photon energy to repair
DNA and reset the circadian clock. Oncogene 21: 9043-9056, 2002.
242. Kavakli IH, Sancar A: Circadian photoreception in humans and mice. Molec. Interventions 2: 484-492,
2002.
13
243. Van Gelder RN, Gibler TM, Tu D, Embry K, Selby CP, Thompson CL, Sancar A. Pleiotropic effects of
cryptochromes 1 and 2 on free-running and light murine circadian rhythms. J. Neuro Genet. 16: 181-203,
2002.
244. Wisor JP, O’Hara BF, Terao A, Selby CP, Kilduff TS, Sancar A, Edgar DM, Franken P: A role for
cryptochrome in sleep regulation. BMC Neurosci 3: 20 (12495542), 2002.
245. Özgür S, Sancar A. Purification and properties of human blue-light photoreceptor cryptochrome 2.
Biochemistry 42: 2926-2932, 2003.
246. Wang D, Hara R, Singh G, Sancar A, Lippard SJ. Nucleotide excision repair from site-specifically platinum
modified nucleosomes. Biochemistry 42: 6747-6753, 2003.
247. Bermudez VP, Lindsey-Boltz LA, Cesare AJ, Maniwa Y, Griffith JD, Hurwitz J, Sancar A. Loading of the
human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRAD17-RFC in vitro.
Proc. Natl. Acad. Sci. USA 100:1633-1638, 2003.
248. Ögrünç M, Sancar A. Identification and characterization of human MUS81-MMS4 structure-specific
endonuclease. J. Biol. Chem. 278:21715-21720, 2003.
249. Hara R, Sancar A. Effect of damage type on stimulation of human excision nuclease by SWI/SNF chromatin
remodeling factor. Mol. Cell. Biol. 23: 4121-4125, 2003.
250. Thompson CL, Bowes Rickman C, Shaw SJ, Ebright JN, Kelly U, Sancar A, Rickman DW. Expression of
the cryptochrome blue-light photoreceptor in the human retina. Invest. Ophthalmol. Vis. Sci. 44:
4515-4521, 2003.
251. Sancar A. Structure and function of DNA photolyase and cryptochrome blue-light photoreceptors. Chem.
Rev. 103: 2203-2238, 2003.
252. Selby CP, Sancar A. Characterization of transcription-repair coupling factors in E. coli and Humans. Meth.
Enzymol. 371: 300-324, 2003.
253. Worthington EN, Kavakli IH, Berrocal-Tito G, Bondo BE, Sancar A. Purification and characterization of
three members of the photolyase/cryptochrome family blue-light photoreceptors from Vibrio cholerae. J.
Biol. Chem. 278: 39143-39154, 2003.
254. Reardon JT, Sancar A. Recognition and repair of the cyclobutane thymine dimer, a major cause of skin
cancers, by the human excision nuclease. Genes Dev. 17: 2539-2551, 2003.
255. Reardon JT., Sancar, A. Thermodynamic cooperativity and kinetic proofreading in DNA damage
recognition and repair. Cell Cycle 3: 141-144, 2004.
256. Thompson CL, Selby CP, Partch CL, Plante DT, Thresher RJ, Araujo F, Sancar A. Further evidence for the
role of cryptochromes in retinohypothalamic photoreception/phototransduction. Molec. Brain. Res. 122:
158-166, 2004.
257. Ünsal-Kaçmaz K, Sancar A. Quaternary structure of ATR and effects of ATRIP and RPA on its DNA
binding and kinase activities. Molec. Cell. Biol. 24: 1292-1300, 2004.
258. Sancar A, Lindsey-Boltz LA, Ünsal-Kaçmaz K, Linn S. Molecular mechanisms of mammalian DNA repair
and DNA damage checkpoints. Annu. Rev. Biochem. 73: 39-85, 2004.
259. Sancar A. Regulation of the mammalian circadian clock by cryptochrome. J. Biol. Chem. 279:
34079-34082, 2004.
260. Lindsey-Boltz LA, Wauson EM, Graves LM, Sancar A. The human Rad9 checkpoint protein stimulates
carbamoyl phosphate synthetase activity of the multifunctional protein CAD. Nucl. Acids Res. 32:
4524-4530, 2004.
261. Sar F, Lindsey-Boltz LA, Subramanian D, Croteau DL, Hutsell SQ, Griffith JD, Sancar A. Human claspin
is a ring-shaped DNA binding protein with high affinity to branched DNA structures. J. Biol. Chem. 279:
34289-34295, 2004 (cover).
262. Kavakli IH, Sancar, A. Analysis of the role of intraprotein electron transfer in photoreactivation by DNA
photolyase in vivo. Biochemistry 43: 15103-15110, 2004.
263. Saxena C, Sancar A, Zhong D. Femtosecond dynamics of DNA photolyase: energy transfer of antenna
initiation and electron transfer of cofactor reduction. J. Phys. Chem. B. 108: 18025-18033, 2004 (cover).
264. Wang W, Brandt P, Rossi ML, Lindsey-Boltz LA, Podust V, Fanning E, Sancar A, Bambara RA. The
human Rad9-Rad1-Hus1 checkpoint complex stimulates Flap endonuclease 1. Proc. Natl. Acad. Sci.
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267.
268.
269.
270.
271.
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273.
274.
275.
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277.
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279.
280.
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283.
284.
285.
286.
287.
288.
289.
USA 101: 16762-16767, 2004.
Thompson CL, Selby CP, Van Gelder RN, Blaner WS, Lee J, Quadro L, Lai K, Gottesman ME, Sancar A.
Effect of vitamin A depletion on nonvisual phototransduction pathways in cryptochromeless mice. J.
Biol. Rhythms 19: 504-517, 2004.
Sancar A, Reardon JT. Nucleotide excision repair in E. coli and man. Adv. Prot. Chem. 69: 43-71, 2004.
Sancar A: Photolyase and cryptochrome blue-light photoreceptors. Adv. Prot. Chem. 69: 73-100, 2004.
Partch CL, Clarkson MW, Özgür S, Lee AL, Sancar A. Role of structural plasticity in signal transduction by
the cryptochrome blue-light photoreceptor. Biochemistry 44: 3795-3805, 2005.
Partch CL, Sancar A. Cryptochrome and circadian photoreception in animals. Meth. Enzymol. 393:
724-743, 2005.
Wang H, Saxena C, Quan D, Sancar A, Zhong D. Femtosecond dynamics of flavin cofactor in DNA
photolyase: radical reduction, local solvation and charge recombination. J. Phys. Chem. B 109:
1329-1333, 2005.
Hutsell SQ, Sancar A. Nucleotide excision repair, oxidative damage, DNA sequence polymorphism, and
cancer treatment. Clinical Cancer Res. 11: 1355-1357, 2005.
Ünsal-Kaçmaz K, Mullen TE, Kaufman WK, Sancar A. Coupling of human circadian and cell cycles by the
Timeless protein. Mol. Cell. Biol. 25: 3109-3116, 2005.
Saxena C, Wang H, Kavakli IH, Sancar A, Zhong D. Ultrafast dynamics of resonance energy transfer in
cryptochrome. J. Am. Chem. Soc. 127: 7984-7985, 2005.
Gauger MA, Sancar A. Cryptochrome, circadian cycle, cell cycle checkpoints, and cancer. Cancer Res. 65
(15) 6828-6834, 2005.
Reardon JT, Sancar A: Nucleotide excision repair. Progr. Nucl. Acid. Res. Mol. Biol. 79, 183-235, 2005.
DeRosa MC, Sancar A, Barton JK. Electrically monitoring DNA repair by photolyase. Proc. Natl. Acad.
Sci USA 102 (31), 10788-10792, 2005.
Partch CL, Sancar A. Photochemistry and photobiology of cryptochrome blue-light photopigments: The
search for a photocycle. Photochem. Photobiol. 81, 1291-1304, 2005.
Kao YT, Saxena C, Wang L, Sancar A, Zhong D: Direct observation of thymine dimer repair in DNA by
photolyase. Proc. Natl. Acad. Sci. USA 102, 16128-16132, 2005.
Kulaksiz G, Reardon JT, Sancar A. Xeroderma pigmentosum complementation group E protein
(XPE/DDB2): purification of various complexes of XPE and analyses of their damaged DNA binding and
putative DNA repair properties. Mol. Cell. Biol. 25, 9784-9792, 2005.
Jiang G, Sancar A. Recruitment of DNA damage checkpoint proteins to damage in transcribed and
nontranscribed sequences. Mol. Cell. Biol. 26: 39-49, 2006.
Reardon JT, Sancar A. Repair of DNA-polypeptide crosslinks by human excision nuclease. Proc Natl Acad
Sci U S A. 103: 4056-4061, 2006.
Wang W, Lindsey-Boltz LA, Sancar A, Bambara RA. Mechanism of stimulation of human DNA ligase I by
the Rad9-rad1-Hus1 checkpoint complex. J Biol Chem. 281: 20865-20872, 2006.
Reardon JT, Cheng Y, Sancar A. Repair of DNA-protein cross-links in mammalian cells. Cell Cycle. 5:
1366-1370, 2006.
Partch CL, Shields KF, Thompson CL, Selby CP, Sancar A. Posttranslational regulation of the mammalian
circadian clock by cryptochrome and protein phosphatase 5. Proc Natl Acad Sci U S A. 103:
10467-10472, 2006.
Sancar GB, Sancar A: Purification and characterization of DNA photolyases. Meth. Enzymol. 408:
189-213, 2006.
Reardon JT, Sancar A: Purification and characterization of E. coli and human nucleotide excision repair
enzyme systems. Meth. Enzymol. 408: 121-156, 2006.
Selby CP, Sancar A. A cryptochrome/photolyase class of enzymes with single-stranded DNA-specific
photolyase activity. Proc Natl Acad Sci U S A. 103: 17696-17700, 2006.
Ozgür S, Sancar A. Analysis of autophosphorylating kinase activities of Arabidopsis and human
cryptochromes. Biochemistry. 45: 13369-742006, 2006.
Roberts RB, Thompson CL, Lee D, Mankinen RW, Sancar A, Threadgill DW. Wildtype epidermal growth
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293.
294.
295.
295.
296.
297.
298.
299.
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302.
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309.
factor receptor (EGFR) is not required for daily locomotor or masking behavior in mice. J Circadian
Rhythms. 16: 4-15, 2006.
Heffernan TP, Unsal-Kaçmaz K, Heinloth AN, Simpson DA, Paules RS, Sancar A, Cordeiro-Stone M,
Kaufmann WK. Cdc7-Dbf4 and the human S checkpoint response to UVC. J Biol Chem. 282: 9458-9468,
2007.
Unsal-Kaçmaz K, Chastain PD, Qu PP, Minoo P, Cordeiro-Stone M, Sancar A, Kaufmann WK. The human
Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork
displacement. Mol Cell Biol. 27: 3131-3142, 2007.
Sokolova O, Cecala C, Gopal A, Cortazar F, McDowell-Buchanan C, Sancar A, Gindt YM, Schelvis JP.
Resonance Raman spectroscopic investigation of the light-harvesting chromophore in escherichia coli
photolyase and Vibrio cholerae cryptochrome-1. Biochemistry. 46: 3673-3681, 2007.
Song SH, Oztürk N, Denaro TR, Arat NO, Kao YT, Zhu H, Zhong D, Reppert SM, Sancar A. Formation
and function of flavin anion radical in cryptochrome 1 blue-light photoreceptor of monarch butterfly. J
Biol Chem. 282: 17608-17612, 2007.
Lindsey-Boltz LA, Sancar A. RNA polymerase: the most specific damage recognition protein in cellular
responses to DNA damage? Proc Natl Acad Sci U S A. 104: 13213-13214, 2007.
Choi JH, Lindsey-Boltz LA, Sancar A. Reconstitution of a human ATR-mediated checkpoint response to
damaged DNA. Proc Natl Acad Sci U S A. 104: 13301-13306, 2007.
Kao YT, Saxena C, Wang L, Sancar A, Zhong D. Femtochemistry in enzyme catalysis: DNA photolyase.
Cell Biochem Biophys. 48: 32-44, 2007.
Kesseler KJ, Kaufmann WK, Reardon JT, Elston TC, Sancar A. A mathematical model for human
nucleotide excision repair: damage recognition by random order assembly and kinetic proofreading. J
Theor Biol. 249: 361-375, 2007.
Oztürk N, Song SH, Ozgür S, Selby CP, Morrison L, Partch C, Zhong D, Sancar A.Structure and function
of animal cryptochromes. Cold Spring Harb Symp Quant Biol. 72: 119-231, 2007.
Oztürk N, Song SH, Selby CP, Sancar A. Animal type 1 cryptochromes. Analysis of the redox state of the
flavin cofactor by site-directed mutagenesis. J Biol Chem. 283: 3256-3263, 2008.
Sancar A. The intelligent clock and the Rube Goldberg clock. Nat Struct Mol Biol. 15: 23-24, 2008.
Kao YT, Tan C, Song SH, Oztürk N, Li J, Wang L, Sancar A, Zhong D. Ultrafast dynamics and anionic
active states of the flavin cofactor in cryptochrome and photolyase. J Am Chem Soc. 130: 7695-7701,
2008.
Lovejoy KS, Todd RC, Zhang S, McCormick MS, D'Aquino JA, Reardon JT, Sancar A, Giacomini KM,
Lippard SJ. cis-Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent:
Uptake, structure, function, and prospects. Proc Natl Acad Sci U S A. 105: 8902-8907, 2008.
Wisor JP, Pasumarthi RK, Gerashchenko D, Thompson CL, Pathak S, Sancar A, Franken P, Lein ES,
Kilduff TS. Sleep deprivation effects on circadian clock gene expression in the cerebral cortex parallel
electroencephalographic differences among mouse strains. J Neurosci. 28: 7193-7201, 2008.
Sancar A. Structure and function of photolyase and in vivo enzymology: 50th anniversary. J Biol Chem.
283: 32153-32157, 2008.
Kao YT, Saxena C, He TF, Guo L, Wang L, Sancar A, Zhong D. Ultrafast dynamics of flavins in five redox
states. J Am Chem Soc. 130: 13132-13139, 2008.
Oztürk N, Kao YT, Selby CP, Kavakli IH, Partch CL, Zhong D, Sancar A. Purification and characterization
of a type III photolyase from Caulobacter crescentus. Biochemistry. 47: 10255-10261, 2008.
Choi JH, Lindsey-Boltz LA, Sancar A. Cooperative activation of the ATR checkpoint kinase by TopBP1
and damaged DNA. Nucleic Acids Res. 37: 1501-1509, 2009.
Kang TH, Reardon JT, Kemp M, Sancar A. Circadian oscillation of nucleotide excision repair in
mammalian brain. Proc Natl Acad Sci U S A. 106, 2864-2867, 2009.
Ozturk N, Lee JH, Gaddameedhi S, Sancar A. Loss of cryptochrome reduces cancer risk in p53 mutant
mice. Proc Natl Acad Sci U S A. 106, 2841-2846, 2009.
Choi JH, Sancar A, Lindsey-Boltz LA. The human ATR-mediated DNA damage checkpoint in a
reconstituted system. Methods. 48: 3-7, 2009.
16
310. Balakrishnan L, Brandt PD, Lindsey-Boltz LA, Sancar A, Bambara RA.Long patch base excision repair
proceeds via coordinated stimulation of the multienzyme DNA repair complex. J Biol Chem. 284:
15158-15172, 2009.
311. Kang TH, Sancar A. Circadian regulation of DNA excision repair: implications for chrono-chemotherapy.
Cell Cycle. 8: 1665-1667, 2009.
312. Li L, Perdigao J, Pegg AE, Lao Y, Hecht SS, Lindgren BR, Reardon JT, Sancar A, Wattenberg EV, Peterson
LA. The influence of repair pathways on the cytotoxicity and mutagenicity induced by the
pyridyloxobutylation pathway of tobacco-specific nitrosamines. Chem Res Toxicol. 22: 1464-1472, 2009.
313. Ozturk N, Selby CP, Song SH, Ye R, Tan C, Kao YT, Zhong D, Sancar A. Comparative photochemistry of
animal type 1 and type 4 cryptochromes. Biochemistry. 48: 8585-8593, 2009.
314. Lindsey-Boltz LA, Serçin O, Choi JH, Sancar A. Reconstitution of human claspin-mediated
phosphorylation of Chk1 by the ATR (ataxia telangiectasia-mutated and rad3-related) checkpoint kinase.
J Biol Chem. 284: 33107-33114, 2009.
315. Kemp M, Sancar A. DNA distress: just ring 9-1-1. Curr Biol. 19, R733-734, 2009.
316. Kemp MG, Mason AC, Carreira A, Reardon JT, Haring SJ, Borgstahl GE, Kowalczykowski SC, Sancar A,
Wold MS. An alternative form of replication protein A expressed in normal human tissues supports DNA
repair. J Biol Chem. 285: 4788-4797, 2010.
317. Liu Y, Fang Y, Shao H, Lindsey-Boltz L, Sancar A, Modrich P. Interactions of human mismatch repair
proteins MutSalpha and MutLalpha with proteins of the ATR-Chk1 pathway. J Biol Chem. 285:
5974-5982, 2010.
318. Chang CW, Guo L, Kao YT, Li J, Tan C, Li T, Saxena C, Liu Z, Wang L, Sancar A, Zhong D. Ultrafast
solvation dynamics at binding and active sites of photolyases. Proc Natl Acad Sci U S A. 107: 2914-2919,
2010.
319. Sancar A, Lindsey-Boltz LA, Kang TH, Reardon JT, Lee JH, Ozturk N. Circadian clock control of the
cellular response to DNA damage. FEBS Lett. 584: 2618-2625, 2010.
320. Kemp MG, Akan Z, Yilmaz S, Grillo M, Smith-Roe SL, Kang TH, Cordeiro-Stone M, Kaufmann WK,
Abraham RT, Sancar A, Unsal-Kaçmaz K. Tipin-replication protein A interaction mediates Chk1
phosphorylation by ATR in response to genotoxic stress. J Biol Chem. 285: 16562-16571, 2010.
321. Kang TH, Lindsey-Boltz LA, Reardon JT, Sancar A. Circadian control of XPA and excision repair of
cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase.Proc Natl Acad Sci U S A. 107:
4890-4895, 2010.
322. Gaddameedhi S, Kemp MG, Reardon JT, Shields JM, Smith-Roe SL, Kaufmann WK, Sancar A. Similar
nucleotide excision repair capacity in melanocytes and melanoma cells. Cancer Res. 70: 4922-4930,
2010.
323. Choi JH, Lindsey-Boltz LA, Kemp M, Mason AC, Wold MS, Sancar A. Reconstitution of RPA-covered
single-stranded DNA-activated ATR-Chk1 signaling. Proc Natl Acad Sci U S A. 107: 13660-13665,
2010.
324. Li J, Liu Z, Tan C, Guo X, Wang L, Sancar A, Zhong D. Dynamics and mechanism of repair of
ultraviolet-induced (6-4) photoproduct by photolyase. Nature 466: 887-890, 2010.
325. Kang TH, Reardon JT, Sancar A.Regulation of nucleotide excision repair activity by transcriptional and
post-transcriptional control of the XPA protein. Nucleic Acids Res. 39:3176-3187, 2010.
326. Gaddameedhi S, Sancar A. Melanoma and DNA damage from a distance (farstander effect). Pigment Cell
Melanoma Res. 24:3-4, 2011.
327. Ozturk N, Selby CP, Annayev Y, Zhong D, Sancar A. Reaction mechanism of Drosophila cryptochrome.
Proc Natl Acad Sci U S A 108:516-521, 2011.
328. Lindsey-Boltz LA, Sancar A. Tethering DNA damage checkpoint mediator proteins TopBP1 and Claspin to
DNA activates ATR phosphorylation of Chk1. J Biol Chem. 286: 19229-19236, 2011.
329. Kemp MG, Lindsey-Boltz LA, Sancar A. The DNA damage response kinases DNA-PK and ATM are
stimulated by bulky adduct-containing DNA. J Biol Chem. 286: 19237-19246, 2011.
340. Ye R, Selby CP, Ozturk N, Annayev Y, Sancar A. (2011) Biochemical Analysis of the Canonical Model for
the Mammalian Circadian Clock. J Biol Chem 286:25891-902.
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341. Lee JH, Sancar A. (2011) Circadian clock disruption improves the efficacy of chemotherapy through
p73-mediated apoptosis. Proc Natl Acad Sci U S A 108:10668-72.
342. Lee JH, Sancar A. (2011) Regulation of apoptosis by the circadian clock through NF-kB signaling. Proc
Natl Acad Sci U S A 108:12036-41.
343. Liu Z, Tan C, Guo X, Kao YT, Li J, Wang L, Sancar A, Zhong D. (2011) Dynamics and mechanism of
cyclobutane pyrimidine dimer repair by DNA photolyase. Proc Natl Acad Sci U S A 108:14831-6.
344. Gaddameedhi S, Selby CP, Kaufmann WK, Smart RC, Sancar A. (2011) Control of skin cancer by the
circadian rhythm. Proc Natl Acad Sci U S A 108:18790-5.
345. Yilmaz S, Sancar A, Kemp MG. (2011) Multiple ATR-Chk1 pathway proteins preferentially associate with
checkpoint-inducing DNA substrates. PLoS One 6:e22986.
346. Selby CP, Sancar A. (2012) The second chromophore in Drosophila photolyase/cryptochrome family
photoreceptors. Biochemistry 51:167-71.
347. Rivera AS, Ozturk N, Fahey B, Plachetzki DC, Degnan BM, Sancar A, Oakley TH. (2012)
Blue-light-receptive cryptochrome is expressed in a sponge eye lacking neurons and opsin. J Exp Biol
215:1278-86.
348. Liu Z, Guo X, Tan C, Li J, Kao YT, Wang L, Sancar A, Zhong D. (2012) Electron tunneling pathways and
role of adenine in repair of cyclobutane pyrimidine dimer by DNA photolyase. J Am Chem Soc
134(19):8104-14.
349. Kemp MG, Reardon JT, Lindsey-Boltz LA, Sancar A. (2012) Mechanism of release and fate of excised
oligonucleotides during nucleotide excision repair. J Biol Chem 287(27):22889-99.
350. Kemp MG, Sancar A. (2012) DNA excision repair: where do all the dimers go? Cell Cycle
11(16):2997-3002.
351. Gaddameedhi S, Reardon JT, Ye R, Ozturk N, Sancar A. (2012) Effect of circadian clock mutations on DNA
damage response in mammalian cells. Cell Cycle 11(18):3481-91.
352. Lindsey-Boltz LA, Reardon JT, Wold MS, Sancar A. (2012) In Vitro Analysis of the Role of Replication
Protein A (RPA) and RPA Phosphorylation in ATR-mediated Checkpoint Signaling. J Biol Chem
287(43):36123-31.
353. Lee JH, Gaddameedhi S, Ozturk N, Ye R, Sancar A. (2013) DNA Damage-Specific Control of Cell Death
by Cryptochrome in p53-Mutant Ras-Transformed Cells. Cancer Res. 73(2):785-91.
354. Ozturk N, VanVickle-Chavez SJ, Akileswaran L, Van Gelder RN, Sancar A. (2013) Ramshackle (Brwd3)
promotes light-induced ubiquitylation of Drosophila Cryptochrome by DDB1-CUL4-ROC1 E3 ligase
complex. Proc Natl Acad Sci U S A 110(13):4980-5.
355. Hassan BH, Lindsey-Boltz LA, Kemp MG, Sancar A. (2013) Direct role for the replication protein Treslin
(Ticrr) in the ATR-mediated checkpoint response. J Biol Chem. 288(26):18903-10.
356. Hu J, Choi JH, Gaddameedhi S, Kemp MG, Reardon JT, Sancar A. (2013) Nucleotide Excision Repair in
Human Cells: Fate of the Excised Oligonucleotide Carrying DNA Damage In Vivo. J Biol Chem.
288(29):20918-26.
357. Ozkan-Dagliyan I, Chiou YY, Ye R, Hassan BH, Ozturk N, Sancar A. (2013) Formation of Arabidopsis
Cryptochrome 2 Photobodies in Mammalian Nuclei: Application as an Optogenetic DNA Damage
Checkpoint Switch. J Biol Chem. 288(32):23244-51.
358. Liu Z, Zhang M, Guo X, Tan C, Li J, Wang L, Sancar A, Zhong D. (2013) Dynamic determination of the
functional state in photolyase and the implication for cryptochrome. Proc Natl Acad Sci U S A
110(32):12972-7.
359. Liu Z, Tan C, Guo X, Li J, Wang L, Sancar A, Zhong D. (2013) Determining complete electron flow in the
cofactor photoreduction of oxidized photolyase. Proc Natl Acad Sci U S A 110(32):12966-71.
Book Chapters:
1.
Sancar A: A study on photoreactivating enzyme (DNA photolyase) of Escherichia coli. Ph.D. dissertation,
University of Texas at Dallas, University Microfilms, Ann Arbor, MI, 1977.
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Rupert CS, Sancar A: Cloning of the phr gene of Escherichia coli. In: DNA repair mechanisms [eds. PC
Hanawalt, EC Friedberg, CF Fox] Academic Press, New York, pp. 159-162, 1978.
Sancar A, Rupert CS: A general method for isolation of repair-deficient mutants. In: DNA repair
mechanisms [eds. PC Hanawalt, EC Friedberg, CF Fox] Academic Press, New York, pp. 101-104, 1978.
Rupp WD, Sancar A, Kennedy WJ, Ayers J, Griswold J: Cloning of E. coli DNA repair genes. In: DNA
Repair mechanisms [eds. PC Hanawalt, EC Friedberg, CF Fox] Academic Press, New York, pp. 229-235,
1978.
Sancar A, Rupert CS: Cloning the gene for E. coli photoreactivating enzyme. In: DNA Repair: A
Laboratory Manual of Research Procedures [eds. EC Friedberg, PC Hanawalt] Marcel Dekker, Inc., New
York. Vol. 2, pp. 241-252, 1983.
Sancar A, Rupp WD: Cloning the uvrA and uvrB genes of E. coli and the use of the Maxicell procedure for
detecting gene expression. In: DNA Repair: A Laboratory Manual of Research Procedures [eds. EC
Friedberg, PC Hanawalt] Marcel Dekker, lnc., New York. Vol. 2, pp. 253-265, 1983.
Jorns MS, Sancar GB, Sancar A: Studies on Escherichia coli DNA Photolyase: Role of Flavin in DNA
Repair. In: Flavins and Flavoproteins [eds. RC Bray, P. C. Engel, S. G. Mayhew] Walter de Gruyter and
Co., Berlin-New York, pp. 861-874, 1984.
Sancar GB, Sancar A: DNA photolyase from E. coli purification and use. In: DNA Repair: A Laboratory
Manual of Research Procedures [eds. EC Friedberg, PC Hanawalt] Marcel Dekker, Inc., New York, Vol.
3, pp. 463-480, 1988.
Sancar A, Thomas DC, Van Houten B, Husain I: Purification and properties of ABC excision nuclease and
its utilization in detecting bulky DNA adducts. In: DNA Repair: A Laboratory Manual of Research
Procedures [eds. EC Friedberg, PC Hanawalt] Marcel Dekker, Inc., New York, Vol. 3, pp. 481-510, 1988.
Page JD, Husain I, Chaney SG, Sancar A: In vitro Repair of Cisplatin-DNA Adducts by a Defined Enzyme
System. In: Platinum and other Metal Coordination Compounds in Cancer Chemotherapy. [Ed.: M.
Nicolini], Nijhoff, Boston, pp. 115-126, 1988.
Orren DK, Sancar A: Subunits of ABC Excinuclease Interact in Solution in the Absence of DNA. In:
Mechanisms and Consequences of DNA Damage Processing. UCLA Symposia New Series 83, pp.
87-94, 1988.
Cheng S, Van Houten B, Gamper HB, Sancar A, Hearst JE: Use of Triple-stranded DNA Complexes to
Study Crosslink Repair. In: Mechanisms and Consequences of DNA Damage Processing. UCLA
Symposia New Series 83, pp. 105-113, 1988.
Van Houten B, Gamper HB, Hearst JE, Sancar A: Factors Influencing the Assembly and Turnover of ABC
Excinuclease. In: Mechanisms and Consequences of DNA Damage Processing. UCLA Symposia New
Series 83, pp. 79-86, 1988.
Reardon JT, Sancar A: The Repair of UV Damaged DNA. In: Nucleic Acids and Molecular Biology. [Eds.:
F. Eckstein and D.M.J. Lilley] Vol. 5, 54-71, 1991.
Sancar A: Photolyase: DNA repair by photoinduced electron transfer. In: Advances in Electron Transfer
Chemistry [Ed. P.E. Mariano] JAI Press, London, Vol. 2, pp. 215-272, 1992.
Kim ST, Malhotra K, Sancar A: Functional and structural characterization of E coli photolyase by
biophysical methods and genetic engineering. In: Biological Responses to Ultraviolet A Radiation [Ed.:
F. Urbach], pp. 121-129, 1992.
Sancar A: Recognition of DNA damage and repair. In: Proteins that Manipulate DNA structure [Ed.:
D.M.J. Lilley] Oxford University Press, Oxford, 90-113, 1995.
Bessho T, Sancar A: Nucleotide excision repair in man. Nucleic Acids and Molecular Biology 12: 141-155,
1998.
Reardon JT, Sancar A: Molecular mechanism of nucleotide excision repair in mammalian cells. In: DNA
Damage and Repair [Eds. M. Dizdaroglu and A.E. Karakaya] NATO Series: 377-393, 1998.
Reardon, JT, Sancar, A: Excision Repair in: Encyclopedia of Genetics, Academic Press, 673-675, 2001.
Sancar A, Thompson, C: Base excision repair. In: Encyclopedia of Molecular Biology [Ed.: T. E.
Creighton] John Wiley & Sons, Inc., New York, 256-258, 2002.
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Sancar A, Thompson, C: DNA damage, inducible responses to. In: Encyclopedia of Molecular Biology
[Ed.: T. E. Creighton] John Wiley & Sons, Inc., New York, 698-701, 2002.
Sancar A, Thompson, C: DNA glycosylases. In: Encyclopedia of Molecular Biology [Ed.: T. E. Creighton]
John Wiley & Sons, Inc., New York, 708-709, 2002.
Sancar A, Thompson, C: DNA repair. In: Encyclopedia of Molecular Biology [Ed.: T. E. Creighton] John
Wiley & Sons, Inc., New York, 718-720, 2002.
Sancar A, Thompson, C: Excision repair. In: Encyclopedia of Molecular Biology [Ed.: T. E. Creighton]
John Wiley & Sons, Inc., New York, 868-873, 2002.
Sancar A, Thompson, C: O6-methylguannine-DNA methyltransferase (MGMT). In: Encyclopedia of
Molecular Biology [Ed.: T. E. Creighton] John Wiley & Sons, Inc., New York, 1490-1491, 2002.
Sancar A, Thompson, C: Mismatch repair. In: Encyclopedia of Molecular Biology [Ed.: T. E. Creighton]
John Wiley & Sons, Inc., New York, 1510-1512, 2002.
Sancar A, Thompson, C: Photolyase/photoreactivation. In: Encyclopedia of Molecular Biology [Ed.: T. E.
Creighton] John Wiley & Sons, Inc., New York, 1843-1847, 2002.
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