GENETIC DISORDER CORNER COMPUTER LAB
Name
Date
Hour
Go to this website: http://gslc.genetics.utah.edu/units/disorders/karyotype/.
1.
Click on “What are chromosomes?” Look at the cell below. You’ll see actual chromosomes
from a person’s cell. Move the focus to see what happens. What happens?
2.
Chromosomes are compact spools of DNA. How long would the DNA be if you were to
stretch all of it out in one of your cells?
3.
When are chromosomes best seen?
4.
The dye “Giemsa” does something to the chromosomes to stain them? What is it?
5.
Click on “How do scientists read chromosomes?”. What are the three key features that
scientists look for?
Scroll down to the bottom. You don’t have to read the information on what centromeres are for unless
you want to. Click on the link “Making a karyotype”.
6.
Play the animation “Organize the chromosomes into a karyotype”. After the chromosomes are
lined up, identify which chromosome pair doesn’t match. Which one is it?
7.
Scroll back up to the top of the screen to the yellow box to the right. Do the try it yourself
activity, “Matching up chromosomes in a karyotype.” It’s ok to use the hints box. When
finished, do you have a male or female?
Click close so you’re back at the original karyotype screen. Scroll to the bottom of the screen and click
on the link “Using karyotypes to predict genetic disorders.”
You should be on the page titled “Using Karyotypes to Predict Genetic Disorders”. If you aren’t here, the
website is: http://gslc.genetics.utah.edu/units/disorders/karyotype/karyotypeinfo.cfm.
8.
Define Karyotype –
9.
Define autosomes-
10.
What is meiosis?
Play the Image File – Meiosis. This will show you how normal meiosis works.
11.
How can cells end up with too many or too few chromosomes?
Play the Image File – Abnormal Meiosis.
To the right of this you have 3 disorders, Down Syndrome, Turner Syndrome, and Klinefelter
Syndrome. Define each.
12.
Down Syndrome-
13.
How many people does Down Syndrome affect?
14.
What are three possible effects of Down Syndrome?
15.
What else is Down Syndrome called?
16.
Where does the extra chromosome come from 90% of the time?
Why?
Play the image file to see how Trisomy occurs.
17.
During Trisomy, how many chromosomes does the egg have?
sperm?
How about the
You’ll have to click on the back arrow at the top of the screen to get to where you were before.
18.
How many people does Turner Syndrome effect?
19.
What are the symptoms? (5 of them)
20.
How do girls get this syndrome?
What is another word for this?
21.
Where does the single X chromosome come from most of the time?
Click on the back arrow at the top of the screen to get to where you were before.
22.
How many people does Klinefelter Syndrome effect?
23.
What is the chromosomal make-up for people with Klinefelter Syndrome?
24.
What are the symptoms of Klinefelter Syndrome?
Click on the back arrow at the top of the screen to get to where you were before.
Play the image files for monosomy ad trisomy to see how they work.
25.
What are two examples of disorders caused by chromosomal deletions?
26.
What is a terminal deletion?
27.
Cri du chat Syndrome is French for?
28.
Why is it called this?
29.
What chromosome does Cri-du-chat occur on?
30.
Play the image file on deletions. What is an interstitial deletion?
31.
Play the image file on Translocations. What is a reciprocal translocation?
32.
What is an example of a disorder where this type of translocation occurs?
33.
Scroll back up to the top of the screen. Look in the top yellow box. What are we unable to see
in a karyotype?
34.
In the bottom yellow box, test your knowledge by linking on to the quiz. How many answers
did you get correct?
Extra credit
Go to the website: http://gslc.genetics.utah.edu/units/disorders/nf1/
Click on the link: “What causes NF1?”. Read through the information and then click on the link in the
top yellow box. The link says, “Finding a gene on the Chromosome map.”
Read through the information. Then click on the student activity. It’s titled “Find the gene for Whirling
Disorder!”
1.
What puzzle piece do you think causes the disorder?
2.
What puzzle piece actually causes the disorder?
Do the bonus questions.
You can copy and paste your answers on a word document and send it to me for extra credit. My
email address is lbiehn@mahtomedi.k12.mn.us.
You can also write down the individual answers or type them and send that to me in an email.
Additional Extra Credit
Go to the website: http://gslc.genetics.utah.edu/units/disorders/sloozeworm/
Read the information and if you need to click the link on the bottom of the page to learn more about what
causes DNA mutations. IF you click the link at the bottom, you’ll have to click on the back button.
Click the link in the yellow box at the top “Slooze Worm Mutagagenesis”. Read through it. Answer the
question at the bottom.
1. What was your answer?
Were you correct?
Answer the challenge questions at the top right of the screen. You can do this on paper or send it to me in
an email.
Check your answers. How many did you have correct?