Program of Study
:
GENERAL MEDICINE
Course
:
PATHOLOGICAL PHYSIOLOGY
Abbreviation
:
PFY/VAA11
Schedule
:
30 hours of lectures
45 hours of exercises
Course Distribution
:
3rd year, 5th semester
Number of Credits
:
0
Course Form
:
Lectures, exercises
Lectures :
Teachers :
prof. MUDr. Martin Petřek, CSc.
MUDr. Dagmar Riegrová, CSc.
Study:
Continuous
Time
11:45 – 13:15 (mondays)
Location:
LLH - Left Lecture Hall
Date
1
2
3
4
5
6
7
8
9
10
14. 9. 2015
21. 9. 2015
28. 9. 2015
5. 10. 2015
12. 10. 2015
19. 10. 2015
26. 10. 2015
2. 11. 2015
Title
Introduction to the subject
Pathophysiology of inflammation. Local symptoms,
general symptoms. Acute phase reaction. Laboratory
markers.
Holiday.
Duration
(hrs).
2
2
Pathophysiology of immune response. Hypersensitivity
reactions. Autoimmune diseases.
General pathogenetic mechanisms. Reactive oxygen,
nitrogen, and carbon species. Reperfusion phenomena.
Calcium paradox. PH paradox.
Pathophysiology of haemostasis. Thrombophilia.
2
Pathophysiology of GIT 1. Gastroduodenal ulcer disesase.
Ileus.
Pathophysiology of GIT 2. Disturbances of exocrine
pancreatic functions. Maldigestion and malabsorption.
2
9. 11. 2015
Pathophysiology of the liver. Liver failure.
16. 11. 2015
Pathophysiology of nutrition.
2
2
2
2
2
11
12
13
14
15
23. 11. 2015
30. 11. 2015
7. 12. 2015
14. 12. 2015
21. 12. 2015 - 1.
1. 2016
Diabetes mellitus. Classification and development.
2
Pathophysiology of the central nervous system I. Speech.
Aphasias.
Pathophysiology of the central nervous systém II.
Disturbances of consciousness.
Autonomic nervous system in abdominal cavity –
organisation, functions and disturbances.
Vacation.
2
2
2
2
Exercises :
prof. MUDr. Martin Petřek, CSc.
Teachers :
MUDr. Dagmar Riegrová, CSc.
Other members of the Department
Study:
Continuous
Date
1
2
3
4
5
6
7
17. 9. 2015
24. 9. 2015
1. 10. 2015
8. 10. 2015
15. 10. 2015
22. 10. 2015
29. 10. 2015
Title
Introduction. The organization of exercises.
Recommended study sources (textbooks, web pages)
Safety rules. Health and disease.
Narcosis. Euthanasia.
Basic surgical instrumentarium.
Injection techniques - forms of application, complications.
Training in surgical techniques. 1. Sewing. Types of
stitches. Practical training (alternative materials).
Video: The use of laboratory animals.
Experiment in pathophysiology. Experimental animal,
laboratory animal. Protection of animals. Alternative
approaches.
Training in surgical techniques. 2 . Sewing. Types of
stitches. Practical training (alternative materials).
Cell death. Necrosis, apoptosis, and autophagy. Healing.
Recovery. Pathophysiology of pain.
Pathophysiology of inflammation. Acute and chronic
inflammation. MODS. SIRS. Fever.
Pathophysiology of immune system.
Analysis of clinical cases.
Test No. 1. Content of exercises 1-4, lecture2-4.
Pathophysiology of blood elements. Anaemiasetiopathogenetic classiofication, anaemic syn. Compensatory
mechanisms. Leucopenia, leucocytosis.
Student´s presentations: Porphyrias.
Disturbances of haemostasis. Bleeding. Disorders.
Coagulopathies. DIC.
Pathophysiology of blood substitution, blood transfusion.
Pathophysiology of transplantation.
Duration
(hrs. )
3
3
3
3
3
3
3
8
9
10
11
12
13
14
15
5. 11. 2015
12. 11. 2015
19. 11. 2015
26. 11. 2015
3. 12. 2015
10. 12. 2015
17. 12. 2015
7. 1. 2015
Pathophysiology of GIT: Oesophagus, stomach. Abdominal
pain. Dyspepsia. Nausea. Vomiting. GIT bleeding.
Test No. 2. Content of exercises 5-7.
Pathophysiology of the liver. Icterus. Hepatitis.
Laboratory markers. Bile duct pathophysiology. .
Exocrine pancreas.
Clinical causes analysis.
Pathophysiology of food intake and nutrition states.
Nutrition energetic balance, proteins and nitrogen balance,
malnutrition refeeding syn.
Environmental risk factors in the development of diseases.
Student´s presentations: Hereditary disturbances of
metabolism of amino acids and purines.
Test No. 3. Content of exercises 8-10.
Central and peripheral nervous system disorders.
Sensitive, motor disturbances at the level of the peripheral
neuron, spinal cord and subcortical levels.
Video: Parkinsonism.
Central and peripheral nervous system disorders.
Neurotransmitters. Disturbance of analysers, limbic and
vegetative system.
Cramps. Ataxias. Disturbances of gait. Disturbances of
sleep. Disturbances of speech.
Analysis of clinical cases.
Video: Epilepsy. Narcolepsy.
Student's presentation of selected themes.
Analyses of clinical cases of selected themes –
MODS – mechanisms, symptoms, complications.
Test No. 4. Content of exercises 11-13.
The final test. Credit.
3
3
3
3
3
3
3
3
The exercises are held in the seminar room of the Department of Pathophysiology, on
Thursdays, from 9. 00 a.m. to 11.15 a.m. - group A; from 11.30 a.m to 13.45 p.m. group B; and from 14.30 p.m. to 16.45 p.m. - group C.
Completed by:
Credit
Requirements:
1) Successful attendance of the exercises is expected (one absence
excused without necessity to supply it). Letter of apology is
necessary in the case of another absence(s). No more than three
absences can be excused by the Department. The students may
substitute their absence(s) in week 15 of the semester.
2) Sufficient knowledge of anatomy, biochemistry, and physiology
as well as adequate activity and interaction in discussions
during the exercises is required. Passivity can be assessed by a
teacher as an absence of the student in the exercise.
3) Achieving of at least 70% mean value of the maximum score
attainable in the four tests.
4) In the case of mean scoring less than 70%, the students will
undergo the final credit test in the week 15 of the semester. The
limit is 70% of the maximum score attainable in this test.
5) In the case of scoring between 55%-69% of the maximum in the
final credit test, the student may undergo an oral interview in a
date offered by the Department.
6) In the case of scoring less than 55% of the maximum in the final
credit test, or in the case of falling in the oral interview, there is
possibility for the student to ask, in a written form, the head of
the Department for an extra re-examination.
Literature :
1. Guyton A. C.: Textbook of Medical Physiology. 11th Edition.
Saunders, 2005.
2. McCance K. L., Huether S. E.: Pathophysiology. 6th Edition.
Mosby, 2010.
www. mefanet. cz; http://portal. med. muni. cz/; http://pfyziol. upol.
cz; http://portal. lf1. cuni. cz/;