Mahmoud Elsabahy

advertisement
Mahmoud Elsabahy
21 Gamal Abdel-Naser Street
Sherket Feryal, Assiut, Egypt
Tel: +2 01000 60 74 66
h index = 12
[email protected]
[email protected]
Total citations = 446
Educational qualifications
2011-Present Assistant Director-Laboratory for Synthetic-Biologic Interactions
Nanomedicines for Biomedical Delivery Applications
Department of Chemistry, Texas A&M University
College Station, Texas, United States
Collaboration and Financial Support:
National Institutes of Health: The National Heart Lung and Blood Institute-Program
of Excellence in Nanotechnology
National Institutes of Health: National Institute of Diabetes and Digestive and Kidney
Diseases
Covidien Pharmaceuticals, Inc.
Washington University Medical School and Department of Chemistry
University of California, Santa Barbara
National Cancer Institute
Bio-rad laboratories
2010-Present Lecturer-Department of Pharmaceutics, Faculty of Pharmacy
Director-Assiut Clinical Center of Nanomedicine
Assistant Director-Drug Research Center
Assiut University, Assiut, Egypt
2010-Present Guest lecturer and/or substitute course coordinator Lecturer
CHEM 689/CHEM 555 (Special Topics: Nanomedicine, Texas A&M University and
Washington University in Saint Louis, Saint Louis, MO, USA)-Fall 2013
CHEM 466 (Synthetic Polymer Chemistry, Texas A&M University)-Winter 2012
CHEM 689/CHEM 555 (Special Topics: Nanomedicine, Texas A&M University and
Washington University in Saint Louis, Saint Louis, MO, USA)-Fall 2011
PHARM 124 (Pharmaceutics, University of Waterloo, Canada)-Winter 2010
2013-Present Senior Professors Council
Misr University for Science & Technology
6th of October City, Cairo, Egypt
2010-2011
Research Associate-Delivery & Pharmaceutical Nanotechnology Laboratory
Nanomedicines for topical (dermal & transdermal) gene therapy
Group leader
Supervisor: Prof. Dr. Marianna Foldvari
School of Pharmacy, University of Waterloo, waterloo, Ontario, Canada
1
2009-2010
Postdoctoral Fellowship-Delivery & Pharmaceutical Nanotechnology Laboratory
Nanomedicines for topical (dermal & transdermal) gene therapy
Supervisor: Prof. Dr. Marianna Foldvari
School of Pharmacy, University of Waterloo, waterloo, Ontario, Canada
2006-2009
Ph.D. in Pharmaceutical Sciences, option Pharmaceutical Technology
Polymeric micelles as versatile carriers for drugs and nucleic acids
Supervisor: Prof. Dr. Jean-Christophe Leroux
Faculty of Pharmacy, University of Montreal, Montreal, Quebec, Canada
Degree conferred on January 2010 (The Thesis was rated as excellent)
2005-2006
M.Sc. in Pharmaceutical Sciences, option Pharmaceutical Technology
Development of polymeric carriers for cancer therapy
Supervisor: Prof. Dr. Jean-Christophe Leroux
Faculty of Pharmacy, University of Montreal, Montreal, Quebec, Canada
Exempted from thesis and direct transfer to the Ph.D.
2003-2005
Teaching and Research assistantship
Department of Pharmaceutics, Faculty of Pharmacy
Assiut University, Assiut, Egypt
1998-2003
B.Sc. Honors in Pharmacy
Grade 90.21% “Excellent with Honor”
Rank is the third among 900 students
Faculty of Pharmacy
Assiut University, Assiut, Egypt
Publications
A. Peer-reviewed papers
1. Mahmoud Elsabahy*, Shiyi Zhang, Fuwu Zhang, Zhou J. Deng, Young H. Lim, Hai Wang,
Perouza Parsamian, Paula T. Hammond and Karen L. Wooley*. Surface Charges and Shell
Crosslinks Each Play Significant Roles in Mediating Degradation, Biofouling, Cytotoxicity
and Immunotoxicity for Polyphosphoester-based Nanoparticles. Scientific Reports, 3, 3313
(2013).
“one of the Journals of the Nature Publishing Group”
“Published in collaboration with the Department of Chemical Engineering, Massachusetts
Institute of Technology, Cambridge”
2. Mahmoud Elsabahy*, Ang Li, Fuwu Zhang, Deborah Sultan, Yongjian Liu and Karen L.
Wooley*. Differential immunotoxicities of poly(ethylene glycol)- vs. poly(carboxybetaine)coated nanoparticles. Journal of Controlled Release, 172, 641-652 (2013).
3. Jiong Zou, Fuwu Zhang, Shiyi Zhang, Stephanie F. Pollack, Mahmoud Elsabahy, Jingwei
Fan, and Karen L. Wooley. Poly(ethylene oxide)-block-polyphosphoester-graft-paclitaxel
Conjugates with Acid-labile Linkages as a pH-Sensitive and Functional Nanoscopic Platform
for Paclitaxel Delivery. Advanced Healthcare Materials, DOI: 10.1002/adhm.201300235
(2013).
4. Mahmoud Elsabahy*, Sandani Samarajeewa, Jeffery E. Raymond, Corrie Clark, Karen L.
Wooley*. Shell-crosslinked knedel-like nanoparticles induce lower immunotoxicity than their
non-crosslinked analogs. Journal of Materials Chemistry B, 1, 5241-5255 (2013).
2
5. Mahmoud Elsabahy*, Ritu Shrestha, Corrie Clark, Sara Taylor, Jeffery Leonard, Karen L.
Wooley*. Multifunctional Hierarchically Assembled Nanostructures as Complex Stage-Wise
Dual-Delivery Systems for Coincidental Yet Differential Trafficking of siRNA and
Paclitaxel. Nano Letters, 13, 2172-2181 (2013).
6. Shiyi Zhang, Jiong Zou, Mahmoud Elsabahy, Amolkumar Karwa, Ang Li, Dennis A.
Moore, Richard B. Dorshow, Karen L. Wooley. Poly(ethylene oxide)-block-polyphosphesterbased paclitaxel conjugates as a platform for ultra-high paclitaxel-loaded multifunctional
nanoparticles. Chemical Science, 4, 2122-2126 (2013).
7. Fuwu Zhang, Mahmoud Elsabahy*, Shiyi Zhang, Lily Yun Lin, Jiong Zou, Karen L.
Wooley*. Shell crosslinked knedel-like nanoparticles for delivery of cisplatin: Effects of
crosslinking. Nanoscale, 5, 3220-3225 (2013).
8. Sandani Samarajeewa, Aida Ibricevic, Sean P. Gunsten, Ritu Shrestha, Mahmoud
Elsabahy*, Steven L. Brody*, Karen L. Wooley*. Degradable Cationic Shell Crosslinked
Knedel-like Nanoparticles: Synthesis, degradation, nucleic acid binding and in vitro
evaluation. Biomacromolecules, 14, 1018-1027 (2013).
9. Mahmoud Elsabahy*, Marianna Foldvari*. Needle-free gene delivery through the skin: an
overview of recent strategies. Current Pharmaceutical Design, 41, 7301-7315 (2013).
10. Mahmoud Elsabahy*, Karen L. Wooley*. Cytokines as biomarkers of nanoparticle
immunotoxicity. Chemical Society Reviews, 42, 5552-5576 (2013).
11. Sandani Samarajeewa, Ritu Shrestha, Mahmoud Elsabahy, Amolkumar Karwa, Ang Li,
Ryan P. Zentay, James G. Kostelc, Richard B. Dorshow, Karen L. Wooley. In vitro Efficacy
of Paclitaxel-loaded Dual-responsive Shell Crosslinked Polymer Nanoparticles Having
Orthogonally-degradable Disulfide Crosslinked Corona and Polyester Core Domains.
Molecular Pharmaceutics, 10, 1092-1099 (2013).
12. Shiyi Zhang, Jiong Zou, Fuwu Zhang, Mahmoud Elsabahy, Zhu, J.; Pochan, D. J.; Karen L.
Wooley. Rapid and Versatile Construction of Diverse and Functional Nanostructures Derived
from a Polyphosphoester-based Biomimetic Block Copolymer System. Journal of the
American Chemical Society, 134, 18467-18474 (2012).
13. Ritu Shrestha, Mahmoud Elsabahy*, Hannah Luehmann, Sandani Samarajeewa, Stephanie
Florez-Malaver, Nam S. Lee, Michael J. Welch, Yongjian Liu*, Karen L. Wooley*.
Hierarchically Assembled Theranostic Nanostructures for siRNA Delivery and Imaging
Applications. Journal of the American Chemical Society, 134, 17362-17365 (2012).
14. Ritu Shrestha#, Mahmoud Elsabahy#*, Stephanie Florez-Malaver, Sandani Samarajeewa,
Karen L. Wooley*. Endosomal escape and siRNA delivery with cationic shell crosslinked
knedel-like nanoparticles with tunable buffering capacities. Biomaterials, 33, 8557-8568
(2012).
15. Mahmoud Elsabahy and Karen L. Wooley. Design of polymeric nanoparticles for
biomedical delivery applications. ChemInform Abstract, 43, 173 (2012).
16. Mahmoud Elsabahy* and Karen L. Wooley*. Strategies toward well-defined polymer
nanoparticles inspired by nature: chemistry versus versatility. Journal of Polymer Science
Part A: Polymer Chemistry, 50, 1869-1880 (2012). “Highlight”
17. Mahmoud Elsabahy* and Karen L. Wooley*. Design of polymeric nanoparticles for
biomedical delivery applications. Chemical Society Reviews, 41, 2545-2561 (2012).
“*Top ten most accessed articles in February, March and April 2012”
“Highlighted and selected for the front cover art and free access for six-weeks”
“Among the top ten most accessed reviews in Chem Soc Rev in 2012 {Chem Soc Rev
Editorial – getting back to basics – Chemical Society Reviews, 42, 11-14 (2013)}”
“Among the top 20 articles (number 1) published on the same topic since February
2012 - wipimd.com”
“Highly cited by scholars: Better than 97% of items indexed by Web of Science in
2012”
3
18. Hui Gao, Mahmoud Elsabahy, Elisabeth Giger, Jianbiao Ma, Robert E. Prud’homme and
Jean-Christophe Leroux. Self assembling properties of aminated poly(glycerol
methacrylate)s. Journal of Controlled Release, 152, e133-e191, (2011).
19. Arnaud E. Felber, Bastien Castagner, Mahmoud Elsabahy, Glen F. Deleavey, Masad J.
Damha and Jean-Christophe Leroux. siRNA nanocarriers based on methacrylic acid
copolymers. Journal of Controlled Release, 152, 159-167, (2011).
20. Mahmoud Elsabahy and Marianna Foldvari. Nanotechnology enables superior medical
therapies. Current Drug Delivery, editorial, 8, 225-226 (2011).
21. Mahmoud Elsabahy, Adil Nazarali and Marianna Foldvari. Non-viral nucleic acid delivery:
Key challenges and future directions. Current Drug Delivery, 8, 235-244 (2011).
22. McDonald Donkuru, Ildiko Badea, Shawn Wettig, Ronald Verrall, Mahmoud Elsabahy and
Marianna Foldvari, Advancing non-viral gene delivery: Lipid- and surfactant-based
nanoparticle design strategies. Nanomedicine (Lond) 5, 1103-1127 (2010).
23. Hui Gao, Mahmoud Elsabahy, Elisabeth Giger, Dekun Li, Robert E. Prud’homme and JeanChristophe Leroux. Aminated linear and star-shape poly(glycerol methacrylate)s: synthesis
and self-assembling properties. Biomacromolecules 11, 889-895, (2010).
24. Mahmoud Elsabahy, Nada Wazen, Núria Bayó-Puxan, Glen Deleavey, Marc Servant,
Masad J. Damha and Jean-Christophe Leroux. Delivery of nucleic acids through the
controlled disassembly of multifunctional nanocomplexes. Advanced Functional Materials
19, 3862–3867 (2009).
25. Marie-Hélène Dufresne, Mahmoud Elsabahy and Jean-Christophe Leroux, Characterization
of polyion complex micelles designed to address the challenges of oligonucleotide delivery.
Pharmaceutical Research 25, 2083-2093 (2008).
26. Mahmoud Elsabahy, Mingzhen Zhang, Shao-Ming Gan, Karen C. Waldron and JeanChristophe Leroux, Synthesis and enzymatic stability of PEGylated oligonucleotide duplexes
and their self-assemblies with polyamidoamine dendrimers. Soft Matter 4, 294-302 (2008).
27. Mahmoud Elsabahy, Marie-Ève Perron, Nicolas Bertrand, Ga-er Yu and Jean-Christophe
Leroux, Solubilization of docetaxel in poly(ethylene oxide)-block-poly(butylene/styrene
oxide) micelles. Biomacromolecules 8, 2250-2257 (2007).
B. Refereed book chapters
1. Mahmoud Elsabahy* and Karen L. Wooley*. Core-shell nanoparticles for biomedical
applications, Frontiers of Nanobiomedical Research, Volume 4, World Scientific, Chapter 13,
in press (2013).
2. Mahmoud Elsabahy, Maria Jimena Loureiro and Marianna Foldvari. Application of
nanotechnology in non-invasive topical gene therapy. In; Bawa R, Audette G F, Rubinstein I
(eds), Handbook of Clinical Nanomedicine – From Bench to Bedside, Pan Stanford Series in
Nanomedicine (Raj Bawa, Series Editor), Volume 1, Pan Stanford Publishing/CRC Press,
Singapore, Chapter 21 (2013).
3. Mahmoud Elsabahy, Ildiko Badea, Ron Verrall, MacDonald Donkuru and Marianna
Foldvari. Dicationic gemini nanoparticle design for gene therapy (Tomas Torres and
Giovanni Bottari, Eds.), Organic Nanomaterials, John Wiley & Sons, Inc, Hoboken, Chapter
23, pp. 509-528 (2013).
4. Mahmoud Elsabahy, Marie-Hélène Dufresne and Jean-Christophe Leroux. Polymeric
micelles as versatile carriers for drugs and nucleic acids delivery, In; Torchilin V and Amiji
M (eds), Materials for Nanomedicine, Pan Stanford Publishing, Hackensack, Chapter 4,
pp.169-234 (2010).
4
C. Patents:
1. Shiyi Zhang, Jiong Zou, Mahmoud Elsabahy and Karen L. Wooley. Poly(ethylene oxide)block-polyphosphester-based paclitaxel conjugates as a platform for ultra-high paclitaxelloaded multifunctional nanoparticles. Provisional US patent (Filed October 2, 2012 with the
USPTO, the serial number is 61/708,911, 2012).
D. Participation at scientific conferences
1. Mahmoud Elsabahy. Development of Multifunctional Nanotheranostics for Therapeutic and
Imaging Applications. 63rd Lindau Nobel Laureate Meeting, Lindau, Germany, June 30-July
5, 2013. Selected among 13 young researchers worldwide as a speaker in this meeting.
2. Shiyi Zhang, Fuwu Zhang, Jiong Zou, Mahmoud Elsabahy, Karen L Wooley. Versatile
construction of polyphosphoester-based nanostructures for different biological applications.
245th ACS National Meeting & Exposition, New Orleans, Louisiana, United States, April 711, 2013.
3. Ritu Shrestha, Mahmoud Elsabahy, Hannah Luehmann, Sandani Samarajeewa, Stephanie
Florez-Malaver, Nam S. Lee, Michael J. Welch, Yongjian Liu, Karen L. Wooley.
Hierarchically Assembled Theranostic Nanostructures for siRNA Delivery and Imaging
Applications. Program of Excellence in Nanotechnology, Integrated Nanosystems for
Diagnosis and Therapy, Annual Inter-PEN Meeting, Massachusetts General Hospital, Boston,
MA (October 2012).
4. Shiyi Zhang, Jiong Zou, Fuwu Zhang, Mahmoud Elsabahy, Karen L. Wooley. Oral
presentation at the 244th ACS National Meeting, Philadelphia, PA, United States, August
2012, "Rapid and versatile construction of diverse and functional nanostructures derived from
a polyphosphoester-based biomimetic block copolymer system"
5. Sandani Samarajeewa, Mahmoud Elsabahy, Ritu Shrestha, Ryan Zentay, Karen L. Wooley.
Development of degradable cationic shell crosslinked nanoparticles toward efficient
transfection of nucleic acids. From Abstracts of Papers, 244th ACS National Meeting &
Exposition, Philadelphia, PA, United States, August 19-23, 2012 (2012), PMSE-84.
6. Mahmoud Elsabahy. Nanotechnology in Medicine Workshop, Integrated Nanosystems for
Diagnosis and Therapy, A Program of Excellence in Nanotechnology (PEN), Supported by
the National Heart Lung and Blood Institute (NHLBI), St. Louis, MO (July 2012)
7. Mahmoud Elsabahy, Program of Excellence in Nanotechnology, Integrated Nanosystems
for Diagnosis and Therapy, 3rd Annual Intra-PEN Meeting, Washington University School of
Medicine, St. Louis, MO (July 2012).
8. Mahmoud Elsabahy. Texas A&M Program of Excellence in Nanotechnology group. 1st
Inter-PEN Contract Meeting, St. Louis, MO (November 2011).
9. Arnaud E. Felber, Bastien Castagner, Mahmoud Elsabahy, Glen F. Deleavey, Masad J.
Damha and Jean-Christophe Leroux. Polymeric micelles with detachable shell prepared by
ATRP for siRNA delivery, 242nd National Meeting of the American-Chemical-Society
(ACS), Denver, CO. (August-September 2011).
10. Mahmoud Elsabahy, MacDonald Donkuru, Ildiko Badea, Ronald Verrall and Marianna
Foldvari. pH-Sensitive Gemini Surfactant-Lipid Composite Nanoparticles as Novel
Constructs for Topical Gene Therapy. The 38th annual meeting and exposition of the
controlled release society, Gaylord National Resort and Convention Center, National Harbor,
Maryland (July 2011).
11. Mahmoud Elsabahy, Ildiko Badea, Ronald Verrall and Marianna Foldvari. Cutaneous gene
delivery using pyrene-substituted gemini-lipid nanoparticles. The 14th annual meeting of the
American society of gene & cell therapy, ASGCT translational science training course,
Seattle, Washington (May 2011).
5
12. Marianna Foldvari (CRC), Mahmoud Elsabahy and Torin Huzil. Non-invasive
nanomedicines: Gene and protein delivery systems. Canada Research Chairs (CRC),
Thinking Ahead for a Strong Future, Toronto, Ontario, Canada (November 2010).
13. Evi Saliaj, Mahmoud Elsabahy, Marina Ivanova and Marianna Foldvari. Confocal
microscopic study of diameter dependent delivery of siRNA into keratinocytes by multiwall
carbon nanotubes. NT10 11th International Conference on the Science and Application of
Nanotubes, Montreal, Quebec, Canada (June 2010).
14. Mahmoud Elsabahy, Mingzhen Zhang, Shao-Ming Gan, Karen C. Waldron and JeanChristophe Leroux. PEGylated oligonucleotide duplexes and their self-assemblies with
polyamidoamine dendrimers. The 35th annual meeting and exposition of the controlled
release society, New York, NY (July 2008).
15. Núria Bayó-Puxan, Francis Robert, Jeremy G. Lackey, Nada Wazen, Mahmoud Elsabahy,
Jerry Pelletier, Masad J. Damha and Jean-Christophe Leroux. Improving the intracellular
delivery and efficacy of FANA oligonucleotides through lipophilic conjugation. The 35th
Northeastern Regional Meeting of the American Chemical Society, Burlington, VT (June
2008).
16. M. J. Damha, J. K. Watts, N. Bayó, J. Lackey, G. Deleavey, N. Wazen, Mahmoud Elsabahy
and Jean-Christophe Leroux. RNA Targeting with 2’-Fluoro-2’-deoxyarabinonucleic acids
(2'F-ANA). American Chemical Society Conference, New Orleans, LA (April 2008).
17. Mahmoud Elsabahy, Ga-er Yu and Jean-Christophe Leroux. Solubilization of docetaxel in
poly(ethylene oxide)-block-poly(butylene/styrene oxide) micelles. The 10th Canadian Society
for Pharmaceutical Sciences, Montreal, Quebec, Canada (June 2007).
18. Mahmoud Elsabahy, Ga-er Yu and Jean-Christophe Leroux. Solubilization of docetaxel in
poly(ethylene oxide)-block-poly(butylene/styrene oxide) micelles. The Annual General
Assembly (McGill University), Montreal, Quebec Canada (March 2007).
*Corresponding authors
#
Equally contributed to the manuscript
Scholarships and Awards







The "Best Ph.D. Thesis" in Assiut University (Egypt). This prestigious award was given on
February 10, 2013 by the Minister of Higher Education, the Mayor and the President of the
University.
Selected among the 550 most qualified young researchers worldwide to attend the 63rd
Lindau Nobel Laureate Meeting (June 30-July 5, 2013, Lindau, Germany). Selected among
only 13 young researchers as a speaker in this meeting. Highlighted in Lindau Nature
and Nature Middle East (doi:10.1038/nmiddleeast.2013.102; Published online 15 July
2013), Youm 7 and Al-Ahram Newspaper.
NSERC VF (Natural Sciences and Engineering Research Council of Canada Visiting
Fellowship) (June 2011).
NSERC IRDF (Natural Sciences and Engineering Research Council of Canada Industrial
R&D Fellowship) (March 2011).
Academic merit award (J. A. DeSève) (September 2008)
Faculté des études supérieures et postdoctorales; Faculty excellence scholarship (May 2007)
Faculté des études supérieures et postdoctorales; University excellence scholarship
(September 2006)
6
Research/Professional experience




Actively participating in the National Heart Lung and Blood Institute-supported Program of
Excellence in Nanotechnology (2011-present).
Establishment and operation of a shared research facility infrastructure (Texas A&M
University, USA)
Guest Editor of Special Issue on Nanomedicines for Current Drug Delivery (2009-2011)
Peer-reviewer of European Journal of Pharmaceutics and Biopharmaceutics
(acknowledged in European Journal of Pharmaceutics and Biopharmaceutics 81 (2012) v–
viii) and Current Drug Delivery Journals, Journal of Polymer Science Part A: Polymer
Chemistry, Accounts of Chemical Research, Future Medicine, Journal of Controlled Releases
(2009-2011).
Training courses
 Laser scanning confocal microscopy (LSM 710)
 BioplexTM immunoassay and BioanalyzerTM
 Atomic force microscopy and transmission electron microscopy
 Animal and radioactivity training
Fluorescence Cross-Correlation Spectroscopy (Confocor III):
Classroom/hands-on training modules for specific experiments in sample preparation,
microscope setup and data analysis and live cell samples
Microscopy Learning Center
David H. Murdock Research Institute (DHMRI)
150 Research Campus Drive
Kannapolis, North Carolina
Dr. Joel Schwartz (Associate Director of Light Microscopy, [email protected])
Software
1.
2.
3.
4.
5.
6.
7.
8.
9.
Microsoft Office applications (Word, PowerPoint, Excel)
Adobe Professional
Autodesk 3ds Max: 3D Modeling, Animation and Rendering
Bio-plex Data Pro: Graphs and statistical analysis of multiplex-assay
Canvas 12: Illustration software and graphics
GraphPad Prism 5: Graphs and statistical analysis
Image Lab: Analytical software
ChemBioDraw: Chemical and biological structures and drawing
OriginLab: Graphs and statistical analysis
7
Download
Related flashcards
Preservatives

48 Cards

Disinfectants

40 Cards

Alveolata

16 Cards

Create flashcards