F r o m h u m a n m e t a b o l i s m t o P o W e r i n G t h e P l a n e t

A G E N D A
12:25 – 1:45Pm
2:00 – 3:00Pm
3:15 – 5:30Pm thursday, January 12, 2012
8:00am – 5:00Pm Registration
8:30 – 9:00am Membership Meeting
9:00 – 9:15am (protégés and special guests join the meeting)
Regency FoyeR (2nd FlooR)
Regency BallRoom (2nd FlooR)
9:15 – 9:30am Welcoming Remarks Regency BallRoom (2nd FlooR)
Michael S. Brown, M.D. (noBel lauReate, Iom, naS) ; Regental Professor,
The University of Texas Southwestern Medical Center
The Honorable Annise D. Parker ; Mayor of Houston
9:30 – 10:55am The Shale Gas Miracle: A Tribute to George P. Mitchell
Featured SpeakerS:
Dan B. Steward ; Geologist, Republic Energy
Mark D. Zoback, Ph.D. (nae) ; Benjamin M. Page Professor of Geophysics, Stanford University
11:00am – 12:10Pm PANEL 1: The Answer is Blowing in the Wind
Moderator:
Kishor C. Mehta, Ph.D. (nae) ; P.W. Horn Professor of Civil Engineering, Texas Tech University;
Program Director, National Science Foundation paneliStS:
Richard E. Williams ; President, Shell WindEnergy, Inc.
Dan Woodfin ; Director of System Planning, Electric Reliability Council of Texas
Luciano Castillo, Ph.D.
; Don-Kay-Clay Cash Distinguished Engineering Chair in Wind Energy
and Director/President of the National Wind Resource Center (NWRC), Texas Tech University
6:00 – 7:00Pm
7:00 – 8:45Pm
Opening Luncheon keynote:
Marvin E. Odum ; President, Shell Oil Company gRand Salon (loBBy level)
PANEL 2: Energy, Medicine and Nanotechnology
Moderator and paneliSt:
Michael B. Kastan, M.D., Ph.D. (Iom) ; Executive Director, Duke Cancer Institute; Professor,
Pharmacology and Cancer Biology and Professor of Pediatrics, Duke University paneliStS:
Mauro Ferrari, Ph.D.
; President and CEO, Ernest Cockrell Jr. Distinguished Endowed Chair,
The Methodist Hospital Research Institute
Mitchell A. Lazar, M.D., Ph.D. (Iom) ; Director of the Institute for Diabetes, Obesity and Metabolism,
University of Pennsylvania School of Medicine
Presentations by the Recipients of the 2012 Edith and Peter O’Donnell Awards
Networking and Reception Palm couRt (loBBy level)
O’Donnell Awards Dinner
Special addreSS:
The Honorable Kay Bailey Hutchison ; United States Senator
Featured Speaker: gRand Salon (loBBy level)
Bruce A. Beutler, M.D. (noBel lauReate, Iom, naS) ; Director, Center for the
Genetics of Host Defense, The University of Texas Southwestern Medical Center
After Dinner Reception Palm couRt (loBBy level)

A G E N D A
Friday, January 13, 2012
7:00 – 8:00am Buffet Breakfast colonnade a (2nd FlooR)
8:00 – 8:30am The Obesity Epidemic Regency BallRoom (2nd FlooR) keynote:
William H. Dietz, M.D., Ph.D. (Iom) ; Director, Division of Nutrition, Physical Activity and Obesity,
National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control
and
8:35 – 10:40am PANEL 3: Mechanisms and Prevention of Obesity and Obesity-related Diseases
Moderator: paneliStS:
Lawrence C. B. Chan, M.D., D.Sc.
Joel K. Elmquist, D.V.M., Ph.D.
Jay D. Horton, M.D.
Dennis M. Bier, M.D. (Iom)
; Betty Rutherford Chair for Diabetes Research and Director of the
Diabetes & Endocrinology Research Center, Baylor College of Medicine
; Professor and Director of the Division of Hypothalamic Research,
The University of Texas Southwestern Medical Center
; Dr. Robert C. and Veronica Atkins Chair in Obesity and Diabetes Research,
The University of Texas Southwestern Medical Center
; Professor of Pediatrics and Director of the Children’s Nutrition Research
Center, Baylor College of Medicine
Deanna M. Hoelscher, Ph.D., R.D., L.D., C.N.S
; Director of the Michael & Susan Dell Center for
Healthy Living and John P. McGovern Professor in Health Promotion, The University of Texas School of
John P. Foreyt, Ph.D.
; Director of the Behavioral Medicine Research Center, Baylor College of Medicine
Amelie G. Ramirez, Dr.P.H., M.P.H. (Iom) ; Professor of Epidemiology and Biostatistics and Director of the
Institute for Health Promotion Research, The University of Texas Health Science Center at San Antonio
10:40 – 10:55am BREAK
10:55 – 11:25am 2011 Texas Energy Summit Report Regency BallRoom (2nd FlooR)
Speaker:
Stephen A. Holditch, Ph.D. (nae) ; Director, Texas A&M Energy Engineering Institute;
11:25 am – 12:00Pm The Scientific Importance and Competitive Advantage of Supercomputing to Texas
Speaker:
John R. (Jay) Boisseau, Ph.D.
; Director, Texas Advanced Computing Center, The University of Texas
12:00 – 12:30Pm Reasoning Mind: Rethinking the Future of Math Education
Speaker:
Alexander R. Khachatryan, Ph.D.
; President and CEO, Reasoning Mind, Inc.
12:30 – 2:00Pm Closing Luncheon gRand Salon (loBBy level)
Featured Speaker:
Samuel C.C. Ting, Ph.D. (noBel lauReate, naS) ; Thomas Dudley Cabot Professor of Physics,
Massachusetts Institute of Technology cloSing reMarkS:
William R. Brinkley, Ph.D. (Iom) ; Emeritus Dean, Graduate School of Biomedical Sciences;
Medicine; 2012 TAMEST President
Distinguished Service Professor, Department of Molecular and Cellular Biology, Baylor College of

K E Y N O T E S P E A K E R S
Director, Division of Nutrition, Physical Activity and Obesity
National Center for Chronic Disease Prevention and Health Promotion, Centers for
Disease Control and Prevention
Dr. William Dietz is director of the Division of Nutrition, Physical Activity and Obesity at the Center for Chronic Disease Prevention and Health Promotion at the Centers for
Disease Control and Prevention (CDC). Prior to his appointment to the CDC, he was a
Professor of Pediatrics at Tufts University’s School of Medicine and director of Clinical
Nutrition at the Floating Hospital of New England Medical Center Hospitals. He received his B.A. from Wesleyan University in 1966 and his M.D. from the University of Pennsylvania in 1970. After the completion of his residency at Upstate Medical
Center, he received a Ph.D. in Nutritional Biochemistry from Massachusetts Institute of Technology. He has been a councilor and past president of the American Society for Clinical Nutrition and past president of the North American Association for the
Study of Obesity. He served on the 1995 Dietary Guidelines Advisory Committee. From
2001–2003, he served as a member of the Advisory Board to the Institute of Nutrition,
Metabolism and Diabetes of the Canadian Institutes for Health Research.
In 1995, Dr. Dietz received the John Stalker Award from the American School Food
Service Association for his efforts to improve the school lunch. In 1997, he received the Brock Medal of Excellence in Pediatrics from the New York Academy of Medicine.
In 1998, he was elected to the Institute of Medicine of the National Academy of
Sciences. In 2000, he received the William G. Anderson Award from the American
Alliance for Health, Physical Education, Recreation and Dance and was recognized for excellence in his work and advocacy by the Association of State and Territorial
Public Health Nutrition Directors. In 2002, he was made an honorary member of the American Dietetic Association and received the Holroyd-Sherry Award for his outstanding contributions to the field of children, adolescents and the media.
In 2005, he received the George Bray Founders Award from the North American
Association for the Study of Obesity. In 2006, he received the Nutrition Award from the American Academy of Pediatrics for outstanding research related to nutrition of infants and children. In 2008, he received the Oded Bar-Or Award from the Obesity
Society for excellence in pediatric obesity research. He is the author of over 200 publications in scientific literature and the editor of five books, including Clinical
Obesity in Adults and Children and A Guide to Your Child’s Nutrition .
F r o m h u m a n m e t a b o l i s m

K E Y N O T E S P E A K E R S
President, Shell Oil Company
Director, Upstream Americas
Marvin Odum is president of Shell Oil Company and Director Upstream of Royal
Dutch Shell’s subsidiary companies in the Americas.
Mr. Odum holds positions of board leadership and participation in the Business
Roundtable and the American Petroleum Institute. In addition, he is a member of the
Dean’s Council of the John F. Kennedy School of Government at Harvard University and the Advisory Board of the Cockrell School of Engineering at The University of
Texas at Austin (UT Austin). He also serves on the University Cancer Foundation
Board of Visitors for The University of Texas MD Anderson Cancer Center and is involved with several other Houston-area charities.
Mr. Odum earned a bachelor’s degree in mechanical engineering from UT Austin and a master’s degree in business administration from the University of Houston. He began his Shell career as an engineer in 1982 and has since served in a number of management positions of increasing responsibility in both technical and commercial aspects of energy.
t o P o W e r i n G t h e P l a n e t

O ’ D O N N E l l A w A R D E E S
Professor and Director, Touchstone Diabetes Center,
Department of Internal Medicine, The University of Texas
Southwestern Medical Center
During the progression from the lean to the obese state, adipose tissue undergoes hyperplasia as well as hypertrophy in an attempt to cope with the increased demand for triglyceride storage. This requires a high degree of plasticity at both the cellular and at the tissue level. The vasculature within adipose tissue has to adapt to altered requirements for nutrient and oxygen exchange. To maintain a healthy, non-inflamed phenotype, complex regulatory mechanisms are in place to ensure adipocytes and stromal vascular cells efficiently crosstalk to allow adipose tissue to expand upon increased demand for storage of triglycerides. Metabolically challenged adipose tissue is associated with an increased infiltration of macrophages that enhance local secretion of pro-inflammatory factors, resulting in a decreased release of beneficial adipokines, such as adiponectin.
Dysfunction at the level of adipose tissue causes an impairment of lipid deposition in adipose tissue with a resulting increased accumulation of ectopic fat in the liver.
John W. Cox Professor of Bioengineering and Professor,
Department of Physics & Astronomy, Rice University
I will describe my participation over the past few years in an effort to find fundamental mathematical laws in biology. I will discuss a theory for understanding the emergence of multi-scale, hierarchical structure in biology. I will describe how modular structure in proteins, genetics and biological networks may arise and how it can be understood. I will show the implications of the theory for engineering design, and I will discuss additional examples of structure formation in ecological food networks, developmental pathways, physiology and social networks. I will then turn to theories of the immune system and describe a theory of the immune response to vaccines. I will illustrate this theory by application to the design of the annual influenza vaccine. I will use this theory to explain limitations in the vaccine for dengue fever and to suggest a transport-inspired amelioration of these limitations.

O ’ D O N N E l l A w A R D E E S
Herman and Joan Suit Professor of Astrophysics,
Department of Astronomy, The University of Texas at Austin
Analog CMOS and Embedded Roadmap Manager, Analog
Technology Development, Texas Instruments
An ultimate goal in astronomy is to understand how galaxies form and evolve and the subsequent effects on how stars and planets form. Recent observational and theoretical work suggests that black holes are essential components of galaxies. In fact, they may be one of the keys to understanding how galaxies form and evolve. I will give an overview of observational results for black holes in galaxies. I will focus on the two extreme mass ranges, from whether the smallest stellar systems contain black holes up to black holes in brightest cluster galaxies which harbor the most massive black holes in the Universe. The present results suggest that the black hole correlations span over seven orders of mass. This concordance suggests a more intimate connection between the central black hole and the host galaxy. I will also discuss the future of black hole studies from space and ground.
Non-volatile memories store information in the absence of an applied voltage and hold software code and data for digital circuits. Traditional non-volatile memories (NVMs) require high voltage, long program/erase times and consume significant power. In contrast, digital circuits operate at low voltage, high-speed and consume very little power per gate.
To improve the operation of digital system-on-chips, a new type of low-power, fast-write NVM is needed.
In this presentation, we will review the technology and wide-ranging utilization of a novel embedded NVM created by Texas Instruments: Ferroelectric Random-Access Memory
(FRAM). This memory stores data in the bi-stable crystalline polarization obtained in low-symmetry ferroelectric crystals.
With a combination of fast-write capabilities, low-power operation and nearly-infinite write endurance,
FRAM enables breakthrough system-on-chip performance. To date, TI has sold more than
50 million FRAM-based chips into markets ranging from power-management systems to ultra-low-power medical devices.

T h E S h A l E G A S M i R A c l E : A T R i b u T E T O G E O R G E P. M i T c h E l l he Academy of Medicine, Engineering and Science honors George P. Mitchell for his significant contributions to Texas and the world in the areas of energy development, real estate development and restoration, environmental sustainability and philanthropy.
Born to Greek immigrant parents in Galveston, Texas,
George Mitchell earned a degree from Texas A&M University and graduated first in his class in petroleum engineering.
Mr. Mitchell started an independent oil and gas company,
Mitchell Energy & Development Corporation, and built it into a Fortune 500 company. During his career he participated in the development of approximately 10,000 wells, including more than 1,000 wildcat wells. In the 1980s and 1990s, his company pioneered new technology for horizontal drilling of natural gas that has since been widely adopted by the industry, spawning a new gas boom in North America.
George Mitchell’s interest in sustainable development— a combination of social, economic and environmental protection—inspired his founding of The Woodlands in the
1970s. Now a 28,000-acre planned community north of
Houston with a population of 97,023, The Woodlands has more than 40,000 homes and 1,700 businesses.
Mitchell is known for his philanthropic efforts to revitalize his hometown of Galveston, Texas, as well as his financial support for universities and research organizations, including his alma mater, Texas A&M University. His total contributions to universities and research organizations are on the order of $159M.

T h E S h A l E G A S M i R A c l E : A T R i b u T E T O G E O R G E P. M i T c h E l l
F E A T u R E D S P E A K E R S
Geologist, Republic Energy
Dan Steward is currently a consulting geologist with Republic Energy operating in Dallas, Texas. He received his Bachelor of Science degree in Geology from the
University of Houston in 1972 and has been involved in the oil and gas industry for 46 years. During his career he has been employed by Ames Oil & Gas, Dresser
Magcobar, Shell Oil Company and Mitchell Energy. From 1981–2001, he was at
Mitchell Energy and a member of their Barnett Shale team. During this 20-year period, he held a number of positions within the company management, and in one capacity or another, was always involved with the Barnett Shale Play. After the company’s merger with Devon in 2002, Dan joined Republic Energy and continued his involvement with the Barnett Shale through their activities. This partnership has allowed him to apply the understanding of organic shales acquired from Barnett to other shales across the North American continent.
In 2005, Dan was asked to write a history of the evolution of the Barnett Shale
Play for a book by George P. Mitchell. This history was published in 2007. In addition to this honor Dan was selected by the American Association of Petroleum Geologists to receive their 2007 Explorer of the Year Award for his role in establishing the
Barnett as one of the largest producing gas fields in the country and the model for shale resource plays worldwide.
Benjamin M. Page Professor of Geophysics, Stanford University
Mark Zoback conducts research on in situ stress, fault mechanics and reservoir geomechanics. He was one of the principal investigators of the San Andreas
Fault Observatory at Depth (SAFOD) project in which a scientific research well was successfully drilled through the San Andreas Fault at seismogenic depth. He is the author of a textbook titled Reservoir Geomechanics published in 2007 by
Cambridge University Press, the author/co-author of 300 technical papers and holder of five patents. In 1996, he co-founded GeoMechanics International, where he was chairman of the board until 2008. He currently serves as a Senior Executive
Adviser to Baker Hughes. Dr. Zoback has received a number of awards and honors, including the 2006 Emil Wiechert Medal of the German Geophysical Society and the 2008 Walter H. Bucher Medal of the American Geophysical Union. In 2011, he was elected to the U.S. National Academy of Engineering. He recently served on the
National Academy of Engineering committee investigating the Deepwater Horizon accident and the Secretary of Energy’s committee on shale gas development and environmental protection.

P O w E R i N G T h E P l A N E T
modeRatoR
KIShoR C. Mehta, Ph.D. (nae)
P.W. Horn Professor of Civil
Engineering, Texas Tech University;
Program Director, National Science
Foundation
PanelIStS
RIchaRd E. WIllIamS
President, Shell WindEnergy, Inc.
Wind Energy Investment and
Economic Perspective
The wind industry is at a crossroads in North America. The technologies to convert wind molecules to electrons are improving, long-term reliabilities are beginning to be addressed, turbine costs are falling, safety is improving, and for the most part, the wind farms are delivering good availabilities and production. On the challenging side, however, power and Renewable Energy Credits (REC) prices are falling precipitously, long-term power purchase contracts are becoming harder to get, siting and avian issues are burgeoning and the direction of long-term carbon value and incentives is murky at best. This presentation will explore the relative cost of wind to other generation sources, delve into how the current economic and political conditions are affecting both the manufacturing and installation sectors, and most importantly, look to the future and explore the many very real, technical, operational and commercial opportunities we have to ensure our turbines continue to run for their 20-year lives as they are designed to do. Establishing viable long-term operations is the best way to ensure continued investment now.
Dan WoodFIn
Director of System Planning, Electric
Reliability Council of Texas (ERCOT)
Integrating More Wind Power Into the System
Texans expect electricity to be available on-demand, whenever they turn on the lights. The availability of electricity from wind generation is subject to the vagaries of the wind. If the goal is to maximize the use of wind generation, then the key to that goal is to find ways to resolve those contradictory characteristics in a cost-effective manner. That resolution might come from the implementation of complementary resources on the power system, changes to the operation of the system and/ or changes to consumer expectations and behaviors.
LucIano CaStIllo, Ph.D.
Don-Kay-Clay Cash Distinguished
Engineering Chair in Wind Energy and
Executive Director/President of the
National Wind Resource Center, Texas
Tech University
Key Fundamental Challenges in Wind
Farm Underperformance
Past investigations have determined that wind turbines that operate within an array can display a significant power generation loss of up to 40 percent when compared to a freestanding wind turbine. Thus, their ability to extract kinetic energy from the flow decreases due to complex interactions among them, the terrain topography and the atmospheric boundary layer. More importantly, we need to develop new design approaches that will enable us to reduce the uncertainty in predicting the performance of the array and not necessarily of a single turbine.

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modeRatoR and PanelISt
MIchael B. KaStan, M.D., Ph.D. (Iom)
Executive Director, Duke Cancer
Institute; Professor of Pharmacology and Cancer Biology and Professor of
Pediatrics, Duke University
ATM Links Cancer Development and
Mitochondrial Function
There is a growing appreciation for the critical role of altered intracellular metabolism and altered mitochondrial function in cancer development. The ATM protein kinase is a classical tumor suppressor gene and is a central mediator of cellular responses to DNA breakage. Patients lacking expression of the ATM gene have a rare disorder, Ataxia-Telangiectasia, with pleiotropic phenotypic abnormalities including progressive neurodegeneration, immunodeficiencies, cancer predisposition, insulin resistance, telangiectasia development and infertility. Some of these symptoms are difficult to attribute directly to alterations in DNA damage signaling. These broad-based symptoms and recent data suggest that ATM may have roles that extend beyond its regulation of DNA damage responses. In particular, ATM appears to affect insulin signaling pathways, and new data demonstrating a direct role for ATM in mitochondrial function will be presented. These new insights suggest that
Ataxia-Telangiectasia should be considered, at least in part, as a mitochondrial disease and provide further links between cancer-related DNA damage signaling and more general metabolic signaling pathways.
PanelIStS
MauRo FeRRaRI, Ph.D.
President and CEO, Ernest Cockrell
Jr. Distinguished Endowed Chair,
The Methodist Hospital Research
Institute
Nanomedicine and Cell Energy
Dynamics
Nanomedicine offers the advantage of combining conventional or novel medical therapeutic substances with added functions, such as the ability to vector them to preferential locations in the body, and to avoid or delay entrapment by the biological barriers that provide protective functions but divert the intended therapeutic action, thus causing undesired adverse effects. Most recently, nanomedical platforms have arisen that afford not only preferential targeting at a body location but actually enable the deployment of multiple, different therapeutic payloads at different subcellular sites in a pre-ordained time sequence of actions. For instance, multi-stage delivery systems have been demonstrated in animal models wherein the first stage selectively targets the blood vessels supplying the desired body location (e.g. a malignant tumor) and from that vantage position release, over time, second stage carriers. These, in turn, penetrate the tumor tissue, reach the target cells, penetrate their cell membranes and deploy therapeutic agent or modulators of biological functions to different sites such as the cytoplasm
(as required for RNA interference therapeutics), the nucleus
(gene therapy or anti-proliferative actions), the cell proteinmaking machinery or their multifunctional energy metabolism centers, the mitochondria. It is actually the mitochondria that provide a magnificent template of multi functionality in a nanoscaled body that serves as inspiration for future generations of nanotherapeutic agents in a strategic perspective that may be termed “bio-mimicry at the nanoscale.” Having followed biomimicry approaches at the microscale, replicated some elementary but essential functions of cells in our programs on
“plateloid first-stage vectors” and “leukolike first stage vectors” (mimicking platelets and leukocytes respectively), we are now envisioning the applications of mitochondrial structure and activity principles to second-stage therapeutic nano-componentry to be loaded in the multistage vectors.
MItchell A. LazaR, M.D.,
Ph.D. (Iom)
Director of the Institute for Diabetes,
Obesity and Metabolism, University of Pennsylvania School of Medicine
Energy Metabolism: from the Thyroid to the Nanoscale
Metabolism is the sum of all the physical and chemical processes by which living organized substance is produced and maintained and also the transformation by which energy is made available for the uses of the organism. The energy cost of maintaining the metabolic integrity of the body is called the basal metabolic rate, and its control by thyroid hormone has been recognized for nearly a century. Studies of the mechanism of thyroid hormone action have led to the discovery of receptors which are members of a larger family of nuclear receptors (NRs) that transduce dietary, hormonal and metabolic signals into alterations in gene expression.
Each NR works at thousands of tissue-specific sites in the genome, accompanied by multiprotein machines that modulate the nuclear environment via the epigenome. Mice harboring a mutation that impairs epigenomic regulation by one of these molecular machines (called the nuclear receptor corepressor complex) demonstrate the importance of this concept in mammalian physiology. In the liver, daily oscillation of a NR for heme (called Rev-erba) dictates the diurnal recruitment of this molecular machine to the genome, and complete loss of the epigenomic regulator results in a massively fatty liver. The same apparatus regulates different biological processes in other tissues. Thus, the systemic modulation of genomic structure and function by hormones and the environment is a critical aspect of integrative physiology and energy metabolism.

h u M A N M E T A b O l i S M
modeRatoR
LawRence C.B. Chan, M.D., D.Sc.
Betty Rutherford Chair for Diabetes Research and Director of the
Diabetes & Endocrinology Research
Center, Baylor College of Medicine
PanelIStS
Joel K. ElmquISt, D.V.M., Ph.D.
Professor and Director of the Division of Hypothalamic Research,
The University of Texas Southwestern Medical Center
Unraveling the Pathways in the
Brain Controlling Food Intake, Body
Weight and Blood Glucose Levels
The brain plays a critical role in regulating food intake, body weight and blood glucose levels. Dysfunction of this central regulation results in obesity and type 2 diabetes, two of the most rapidly increasing diseases in the world.
While abnormalities in peripheral tissues contribute to the pathogenesis of obesity and type 2 diabetes, these effects are, for the most part, secondary to and driven by primary dysfunction in the brain. Therefore, to understand the causes and to develop treatments for obesity and type 2 diabetes, it is first necessary to unravel the brain pathways regulating coordinated energy homeostasis and to establish the relevant molecules (neuropeptides, neurotransmitters, receptors, intracellular signaling pathways and ion channels) that operate within these neural circuits. Early on, research in the area of the control of food intake and body weight was limited to destructive anatomic lesions in the brain. These studies identified regions of the hypothalamus as playing important roles. The next advancement was the discovery of ligands
(leptin, α -melanocyte stimulating hormone— α MSH, ghrelin, etc.) and receptors (leptin receptors—LEPRs, melanocortin receptors—MC3Rs and MC4Rs, serotonin receptors, ghrelin receptors—GHSRs, etc.) important in controlling body weight.
This talk will discuss studies using mouse genetic models to perturb specific genes in narrow subsets of neurons. These studies have provided insights into the mechanisms through which the nervous system regulates food intake, body weight and blood glucose levels.
Jay D. HoRton, M.D.
Dr. Robert C. and Veronica Atkins
Chair in Obesity and Diabetes
Research, The University of Texas
Southwestern Medical Center
Molecular Mediators of Hepatic
Steatosis
Non-alcoholic fatty liver disease
(NAFLD) encompasses a disease spectrum ranging from simple triglyceride accumulation in hepatocytes (hepatic steatosis) to hepatic steatosis with inflammation (steatohepatitis), fibrosis and cirrhosis. NAFLD is the most frequent cause of abnormal liver function tests (LFTs) in the U.S. and is strongly associated with insulin resistance and the metabolic syndrome. The molecular and metabolic changes that occur in the liver as a result of insulin resistance have been only partially characterized. One important underlying metabolic change associated with insulin resistance is elevated rates of fatty acid synthesis in liver. The synthesis of fatty acids in liver is regulated independently by insulin and glucose.
Insulin’s ability to activate lipogenesis is transcriptionally mediated by the transcription factor, sterol regulatory element-binding protein-1c (SREBP-1c). Insulin signaling induces SREBP-1c expression in liver. SREBP-1c then activates all genes required for fatty acid synthesis. In insulin resistant states, hyperinsulinemia leads to excessive SREBP-
1c activation, increased fatty acid synthesis and excessive triglyceride accumulation in liver. I will discuss the roles of recently discovered SREBP-1c regulated proteins in the development of NAFLD in obese and insulin-resistant states.
DennIS M. BIeR, M.D. (Iom)
Professor of Pediatrics and Director of the Children’s Nutrition Research
Center, Baylor College of Medicine
Closing the Barn Door Before the
Horse Has Left
A significant fraction of obesity prevention efforts are directed at children of school age. Prevention efforts directed at infants and toddlers are less well established. Likewise, research into prevention approaches and their outcomes in infancy is also meager compared to prevention research studies in older children. In part, this reflects the difficulty of studying infants and toddlers. Nonetheless, a sizeable body of evidence exists that odor, taste and flavor preferences are established, at least in part, very early in life and that there are sensitive, early post-natal developmental windows for human flavor learning. Additionally, animal data has demonstrated important developmental windows for “hard wiring” the neural circuitry of the hypothalamic appetite and satiety centers. Further, this circuitry can be altered experimentally by hormones that regulate appetite and satiety. Sadly, we have virtually no information on the development of eating and physical activity behaviors and their determinants in infancy. Because the

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earlier a child becomes fat, the more obese that child will be later in childhood (or adult life), understanding the developmental determinants of food preferences and eating behaviors is critical to directing prevention efforts during sensitive periods early in life when they might be more effective in the long term.
Deanna M. HoelScheR, Ph.D.,
R.D., L.D., C.N.S.
Director of the Michael & Susan Dell
Center for Healthy Living and John
P. McGovern Professor in Health
Promotion, The University of Texas
School of Public Health
CATCHing Kids in Texas: Obesity
Prevention Using Individual and
Environmental Approaches
Almost one in five children in the U.S. aged six to 19 are obese. The problem is even greater in Texas, where the
School Physical Activity and Nutrition (SPAN) survey found that over 20 percent of 4th, 8th and 11th grade students were obese in 2009–2011. The Coordinated Approach To Child
Health, or CATCH, is a school-based program developed to prevent risk factors for chronic diseases such as cardiovascular disease, type 2 diabetes and obesity. Recent data from
CATCH implementations in elementary schools in El Paso and Austin, Texas, have shown significant decreases in child obesity, especially when combined with community involvement and supportive policies. Despite these results, CATCH implementation in schools is often inconsistent due to lack of funding, the emphasis on standardized educational testing and lack of accountability for health programs. Further policy and programmatic initiatives are needed to support coordinated school health implementation so that the effects from these efforts can be maximized for prevention of child obesity.
John P. FoReyt, Ph.D.
Director of the Behavioral Medicine
Research Center, Baylor College of
Medicine
Successful Behavioral Strategies for
Weight Management
There is an interesting paradox regarding the increasing prevalence of obesity in our society. Although there is increased interest in healthy eating and physical activity and an increased awareness of the dangers of obesity, its prevalence continues to rise. Work and commuting demands, little time to exercise or prepare food, availability of high fat/high calorie foods and other environmental factors all seem to play a role in its increase.
As a society, we’re eating more and exercising less. From a public health point of view, a relatively modest reduction in energy intake and increase in physical activity could slow or stop the weight gain of the population. This presentation will focus on five behavioral steps to successful weight management. Step one involves raising awareness through food, activity and weight records. Step two focuses on confronting the barriers to a healthier lifestyle. Step three focuses on the management of emotional eating, including stress, tension, anxiety, depression, loneliness and anger. Step four involves managing relapses through recognizing and planning ahead for high-risk situations, learning to control urges and enlisting family, peer and community support. Step five focuses on the long-term management of a healthier lifestyle. Outcome data from Look AHEAD, an ongoing 14-year multicenter, randomized clinical trial evaluating the health effects of behavioral interventions in 5,137 obese individuals with type 2 diabetes, will be presented.
AmelIe G. RamIRez, DR.P.H.,
M.P.H. (Iom)
Professor of Epidemiology and Biostatistics and Director of the Institute for Health Promotion Research,
The University of Texas Health Science Center at San Antonio
Tipping the Scales: Reducing Latino
Childhood Obesity with Evidence and Policy Research
Today, one-third of U.S. children are overweight or obese, placing them at an increased risk for heart disease, diabetes and other health problems. Latino children, who belong to the largest, youngest and fastest-growing U.S. minority group, have one of the highest rates of obesity. Recent data shows that 38 percent of Mexican-American children are obese or overweight, versus 30.7 percent of whites and 34.9 percent of African-Americans. Given the continuing meteoric rise of the young U.S. Latino population, evidence-based, culturally adapted approaches are critically needed to spur policy changes and reverse the obesity epidemic, specifically among Latino children. In its first five years, Salud America! The Robert Wood
Johnson Foundation (RWJF) Research Network to Prevent Obesity Among Latino Children, developed an online network of
1,800 Latino childhood obesity researchers, academics, community leaders and other advocates; developed the first ever
Latino Childhood Obesity Research Priority Agenda; funded 20 pilot research projects through RWJF that are bridging the gap in the amount of research and data available on Latinos and identifying the most promising obesity-prevention strategies specifically tailored for Latino communities; developed three research briefs on Latino nutrition, physical activity and social marketing and 20 pilot investigator research briefs to contribute novel evidence on Latino childhood obesity to fuel policy changes at the local, state and national levels; contributed to the development of RWJF’s policy spectra; built the field of
Latino researchers; and raised national awareness about the epidemic through e-communications, scientific summits and dramatic videos. This presentation will focus on framing Latino childhood obesity, the responses to it by Salud America!
and remaining areas of need for future research and policies.

S P E c i A l P R E S E N T A T i O N S
John R. ( Jay) BoISSeau, Ph.D.
Director, Texas Advanced Computing
Center, The University of Texas at
Austin
Advanced computing technologies are now fundamental to enabling discoveries in science, engineering and medicine. Advanced computing, or “supercomputing,” enables modeling and simulation of physical processes, based on our best mathematical understanding, that would otherwise be impossible, and petascale systems promise the potential for multi-scale, multi-physics models with superior fidelity.
Supercomputing is also increasingly used to analyze the vast quantities of digital data being generated and collected by the increasing scale, number and type of digital instruments and sensors that provide high-resolution information about our world. In Texas, we are now among the world leaders in designing, developing and deploying the most powerful and capable advanced computing technologies, as well as in using them in science, engineering and medicine. Having this complementary spectrum of talent and expertise in Texas enables us to provide leadership that augments science and society for the world while providing us with competitive advantages to attract the talent and funding to sustain this leadership. The Texas Advanced Computing Center (TACC) at The University of Texas at Austin proudly supports the advancement of knowledge by open science researchers across the nation and aims to continuously ensure that Texas leads the way to new discoveries that change the world.
AlexandeR R. KhachatRyan, Ph.D.
President and CEO, Reasoning Mind,
Inc.
On international assessments of
K–12 math achievement, the United
States ranks far from the top. Many of the factors contributing to this are known: top-performing nations use high-quality math curricula in their schools, have better-prepared teachers (especially in math content knowledge) and have students who are more engaged in the learning process. Reasoning Mind is a Texas-based non-profit organization working to improve the quality of math instruction through technology. We develop online math programs based on the Russian curriculum, acknowledged as one of the best available. We also work with teachers to improve their math content knowledge and to support them in implementing our programs in their classroom; currently, we serve over 42,000 students and 800 teachers in seven states. Reasoning Mind students show substantially stronger math achievement along with improved attitudes towards the subject. At the presentation, we’ll discuss our approach and demonstrate some learning modes in our program, including the competitive game MathRace.
StePhen A. HoldItch, Ph.D. (nae)
Director, Texas A&M Energy
Engineering Institute
2011 TAMEST President
On April 20, 2011, TAMEST convened the 2011 Texas Energy Summit at the Annenberg Conference Center in College Station, Texas. Texas
A&M University and The Texas A&M
University System served as hosts for this important event that included presentations from the state’s energy leaders from industry, academia and government on the future of electrical power generation and transportation.
The objectives of the 2011 Texas Energy Summit were to review current information in each of the energy sectors represented on the program, examine the challenges to be addressed through scientific and engineering studies and identify potential actions by the legislature or state regulatory agencies needed to address these challenges to meet Texas’ long-term energy needs.
The executive summary of the proceedings of the summit will be distributed at the conference and the full report is available at tamest.org.

F E A T u R E D S P E A K E R
BRuce A. BeutleR, M.D. (noBel lauReate, Iom, naS)
Director, Center for the Genetics of Host Defense, The University of Texas
Southwestern Medical Center
Dr. Bruce A. Beutler re-joined The University of Texas Southwestern Medical Center
(UT Southwestern) in September of 2011, relocating from the Scripps Research
Institute where he was professor and chairman of the Department of Genetics.
Beutler first joined UT Southwestern as an internal medicine intern and neurology resident (1981–1983). He then spent three years at Rockefeller University (1983–
1986), where he isolated tumor necrosis factor (TNF) and established its function as a mediator of inflammation. Returning to UT Southwestern in 1986 as a faculty member and Howard Hughes Medical Institute investigator, Beutler developed TNF inhibitors that were eventually used in the treatment of rheumatoid arthritis and other diseases. Moreover, by positionally cloning the mammalian LPS receptor, he identified the Toll-like receptors (TLRs) as sensors that alert the host immune system when infection is present. This discovery, made in 1998, opened many new doors in immunology and earned Beutler many accolades, including the Nobel Prize in
Physiology or Medicine in 2011.
At the Scripps Research Institute between 2000 and 2011, Dr. Beutler developed one of the most robust gene discovery programs in the world, utilizing germline mutagenesis and phenotypic screening to dissect both innate and adaptive immunity, and other biological processes as well. Several “firsts” emerged from this program, including the development of numerous mouse disease models that predicted human diseases. A similar approach, empowered by new technologies, will be pursued at UT Southwestern, where Beutler and his colleagues will study many aspects of host defense, both as it is activated during infection and during neoplastic disease.

F E A T u R E D S P E A K E R
Samuel C.C. TIng, Ph.D. (noBel lauReate, naS)
Thomas Dudley Cabot Professor of Physics, Massachusetts Institute of Technology
Dr. Samuel Ting was born in Ann Arbor, Michigan. He received his B.S.E. degrees
(in Physics and in Mathematics) and his Ph.D. (in Physics) all from the University of Michigan. Dr. Ting has always proposed and led international collaborations in experimental physics using accelerators in the U.S and Europe, on board the U.S.
Space Shuttle Discovery and currently on the International Space Station (ISS) U.S.
National Laboratory.
His main contributions to physics include:
• Discovery of nuclear anti-matter (the anti-deuteron)
• Measuring the size of the electron family (the electron, the muon and the tau) and showing that the electron family has zero size (with a radius smaller than
10 – 17 cm)
• Precision study of light rays and massive light rays, showing that light rays and massive light rays can transform into each other at high energies and providing a critical verification of the quark model
• Precision measurement of the radius of the atomic nuclei
• Discovery of a new kind of matter (the J particle) at the Brookhaven National
Laboratory (the Nobel Prize was awarded to Ting for this discovery)
• Discovery of the gluon (the particle responsible for transmitting the nuclear force)
• A precision measurement of muon charge asymmetry, demonstrating for the first time the validity of the Standard Electroweak Model (Weinberg, Glashow and
Salam)
• Determination of the number of electron families and neutrino species in the universe and the precision verification of the Electroweak Unification Theory
• Development of the first large superconducting magnet for space application
Dr. Ting’s major awards include the Nobel Prize for Physics, Ernest Orlando
Lawrence Award (U.S. government), Eringen Medal (from the Society of Engineering
Science), DeGaspari Award in Science (from the Italian government) and the World
Federation of Scientists Erice Prize for Peace.
Dr. Ting is a member of many scientific academies including the U.S. National
Academy of Sciences, the American Academy of Arts and Sciences, the Soviet
Academy of Science, the Russian Academy of Science, Deutsche Academy
Naturforscher Leopoldina (Germany), Royal Spanish Academy of Science, Hungarian
Academy of Science, Academia Sinica and the Chinese Academy of Science. He is an
Honorary Fellow of the Tata Institute of Fundamental Research (India).
Among his Doctor Honoris Causa degrees are those awarded by the University of
Michigan, Columbia University, Moscow State University, Rheinische Westfalisch
Technische Hochschule (Germany), University of Bologna (Italy), University of
Bucharest (Romania) and Hong Kong University of Science and Technology.
Presently, he is leading a 16-nation, 500 physicist international collaboration using the U.S. ISS National Laboratory to probe some of the fundamental questions of modern physics including the antimatter universe and the origin of cosmic rays and dark matter.

P R O T é G é S
EdwaRd E. AndeRSon, Ph.D.
Professor, Department of Mechanical
Engineering
Texas Tech University
Kishor Mehta
DoRa AngelakI, Ph.D.
Wilhelmina Robertson Professor &
Chair, Department of Neuroscience
Baylor College of Medicine
Huda Zoghbi
Oguzhan BayRak, Ph.D., P.E.
Professor, Department of Civil,
Architectural and Environmental
Engineering
The University of Texas at Austin
James Jirsa
StePhen D. BoyleS, Ph.D.
Assistant Professor, Department of
Civil, Architectural, and Environmental
Engineering
The University of Texas at Austin
Michael Walton
EzRa BuRSteIn, M.D.
Associate Professor, Department of Internal Medicine and Molecular Biology
The University of Texas Southwestern
Medical Center
Daniel Podolsky
StePhen C. Catha
Director
Smart Pipe Company Inc.
Mel Kanninen
WalteR G. ChaPman, Ph.D.
William W. Akers Professor Chair of
Chemical and Biomolecular Engineering
Rice University
Riki Kobayashi
Lynda ChIn, M.D.
Chair, Department of Genomic Medicine
The University of Texas MD Anderson
Cancer Center
Ellen Gritz
LydIa M. ContReRaS, Ph.D.
Assistant Professor, Department of
Chemical Engineering
The University of Texas at Austin
Isaac Sanchez
MaRk CRawFoRd, Ph.D.
Research Scientist, Institute for
Advanced Technology
The University of Texas at Austin
Hans Mark
RIchaRd M. CRookS, Ph.D.
Robert A. Welch Chair in Materials
Chemistry
The University of Texas at Austin
Peter Rossky
ShaRon Y.R. Dent, Ph.D.
Chair, Department of Molecular
Carcinogenesis
The University of Texas MD Anderson
Cancer Center
Ronald DePinho

P R O T é G é S
Raymond N. DuBoIS, M.D., Ph.D.
Provost and Executive Vice President
The University of Texas MD Anderson
Cancer Center
Kenneth Shine
KaRl B. FISheR, Ph.D.
Director, Signal and Information
Sciences Laboratory, Applied Research
Laboratories
The University of Texas at Austin
William Fisher
BRuce Gnade, Ph.D.
Professor, Department of Materials
Science and Engineering
The University of Texas at Dallas
David Daniel
VeRnIta D. GoRdon, Ph.D.
Assistant Professor, Department of
Physics, Center for Nonlinear Dynamics,
Institute for Cellular and Molecular
Biology
The University of Texas at Austin
Harry Swinney
KaRoloS GRIgoRIadIS, Ph.D.
Professor and Director, Aerospace
Engineering
University of Houston
Pol Spanos
NIck V. GRIShIn, Ph.D.
Professor of Biochemistry, Howard
Hughes Medical Institute
The University of Texas Southwestern
Medical Center
Johann Deisenhofer
ThomaS M. GueRReRo, M.D., Ph.D.
Associate Professor, Department of
Radiation Oncology
The University of Texas MD Anderson
Cancer Center
Richard Tapia
NaomI J. HalaS, Ph.D.
Stanley C. Moore Professor of Electrical and Computer Engineering
Rice University
Robert Curl
Randall G. Hulet, Ph.D.
Fayez Sarofim Professor of Physics
Rice University
James Kinsey
John E. HuRtado, Ph.D.
Associate Professor, Aerospace
Engineering
Texas A&M University
John Junkins

P R O T é G é S
DmItRI Ivanov, Ph.D.
Assistant Professor, Department of
Biochemistry
The University of Texas Health Science
Center at San Antonio
Bettie Sue Masters
AlI KhademhoSSeInI, Ph.D.
Associate Professor
Harvard University
Nicholas Peppas
Sacha E. KoPP, Ph.D.
Associate Dean for Undergraduate
Education, College of Natural Sciences
The University of Texas at Austin
Grant Willson
Adam KuSPa, Ph.D.
Vice President for Research
Baylor College of Medicine
Salih Wakil
Chad M. LandIS, Ph.D.
Associate Professor, Department of
Aerospace Engineering and Engineering
Mechanics
The University of Texas at Austin
Thomas Hughes
KIng C. LI, M.D.
Professor of Radiology
The Methodist Hospital, Weill Cornell
Medical College
Fazle Hussain
ThomaS C. MayeS, M.D., M.B.A
.
Professor and Chairman
The University of Texas Health Science
Center at San Antonio
Fernando Guerra
John T. McDevItt, Ph.D.
Brown-Wiess Professor of
Bioengineering and Chemistry
Rice University
Edwin Thomas
StathIS MIchaelIdeS, Ph.D., P.E.
Professor and W.A. Tex Moncrief
Chair of Engineering, Department of
Engineering
Texas Christian University
Karl Springer
Y.L. Mo, Ph.D.
Professor, Department of Civil
Engineering
University of Houston
Kaspar Willam

P R O T é G é S
RoBeRt MoSeR, Ph.D.
Professor, Institute for Computational
Engineering and Sciences and
Department of Mechanical Engineering
The University of Texas at Austin
Tinsley Oden
ChaRleS R. NeBlett, M.D.
Director
McNair Medical Institute
Bobby Alford
StePhen Pont, M.D., M.P.H.
Medical Director, Texas Center for the
Prevention and Treatment of Childhood
Obesity
Dell Children’s Medical Center /
The University of Texas Southwestern
Medical Center, Austin
William Sage
Maša PRodanovI´c, Ph.D.
Assistant Professor, Department of Petroleum and Geosystems
Engineering
The University of Texas at Austin
Larry Lake
KRIShnaSwamy RavI-ChandaR, Ph.D.
Professor, Department of Aerospace
Engineering and Engineering
Mechanics
The University of Texas at Austin
Stelios Kyriakides
SuSan M. RoSenBeRg, Ph.D.
Ben F. Love Chair in Cancer Research,
Department of Molecular and Human
Genetics
Baylor College of Medicine
Mary Estes
BeRnhaRd A. SchReFleR, Ph.D., D.Sc.
Professor, Department of Civil and
Environmental Engineering
University of Padua
Kaspar Willam
Eva M. SevIck-MuRaca, Ph.D.
Professor, Cullen Chair in Molecular
Medicine; Professor and Director,
Center for Molecular Imaging
The University of Texas Health Science
Center at Houston
Thomas Caskey
AShok K. Shetty, Ph.D.
Professor & Director of Neurosciences,
Institute for Regenerative Medicine
Texas A&M Health Science Center /
Scott & White
Darwin Prockop
KonStantIn Sokolov, Ph.D.
Associate Professor, Department of
Imaging Physics
The University of Texas MD Anderson
Cancer Center
Keith Johnston

P R O T é G é S
JeFF SPath, Ph.D.
Vice President, Industry and University
Relations
Schlumberger
Stephen Holditch
Jeanne C. StachowIak, Ph.D.
Assistant Professor, Department of
Biomedical Engineering
The University of Texas at Austin
Nicholas Peppas
Ben H. ThackeR, Ph.D., P.E.
Director, Materials Engineering
Department
Southwest Research Institute
Norman Abramson
Scott W. TInkeR, Ph.D.
Director, Bureau of Economic Geology
The University of Texas at Austin
Peter Flawn
RaFael VeRduzco, Ph.D.
Louis Owen Assistant Professor in
Chemical and Biomolecular Engineering
Rice University
George Hirasaki
CheRyl Lyn WalkeR, Ph.D.,
A.T.S., F.A.A.A.S.
Welch Professor and Director, Institute of Biosciences and Technology
Texas A&M Health Science Center
Nancy Dickey
YIhong Wan, Ph.D.
Assistant Professor, Department of
Pharmacology
The University of Texas Southwestern
Medical Center
David Mangelsdorf
ThomaS WeStBRook, Ph.D.
Assistant Professor, Departments of
Biochemistry and Molecular Biology
Baylor College of Medicine
Arthur Beaudet
TheodoRe G. WenSel, Ph.D.
Professor of Biochemistry and
Molecular Biology
Baylor College of Medicine
Salih Wakil
MIchael A. WhIte, Ph.D.
Professor of Cell Biology
The University of Texas Southwestern
Medical Center
Melanie Cobb
ShaRon L. Wood, Ph.D.
Department Chair, Civil, Architectural and Environmental Engineering
The University of Texas at Austin
John Breen

T A M E S T l E A D E R S h i P
Honorary Chairman
The Honorable Kay Bailey Hutchison
United States Senator
Founding Co-Chairmen
Dr. Michael S. Brown
Nobel Laureate and Regental Professor
The University of Texas Southwestern
Medical Center
IN MEMORIAM
Dr. Richard E. Smalley
Nobel Laureate
Rice University
2012 Board of Directors
William R. Brinkley, Ph.D.
, President
Emeritus Dean, Graduate School of Biomedical Sciences
Distinguished Service Professor, Department of Molecular
and Cellular Biology
Baylor College of Medicine
IOM (1999)
Stephen A. Holditch, Ph.D.
, Past President
Director of the Texas A&M Energy Engineering Institute
Texas A&M University
NAE (1995)
E. Linn Draper, Jr., Ph.D.
, Vice President
Chairman, President and CEO Emeritus
American Electric Power Company
NAE (1992)
Thomas J.R. Hughes, Ph.D.
, Secretary
Professor of Aerospace Engineering and
Engineering Mechanics
Computational and Applied Mathematics Chair III
The University of Texas at Austin
NAE, NAS (1995, 2009)
Christine Ehlig-Economides, Ph.D.
, Treasurer
Professor, Petroleum Engineering
A.B. Stevens Endowed Chair
Texas A&M University
NAE (2003)
Kenneth E. Arnold, P.E.
, Treasurer-Elect
Senior Technical Advisor
WorleyParsons Inc.
NAE (2005)
Brian J.L. Berry, Ph.D.
Lloyd Viel Berkner Regental Professor
School of Economic, Political and Policy Sciences
The University of Texas at Dallas
NAS (1975)
Baruch A. Brody, Ph.D.
Andrew Mellon Professor in Humanities
Department of Philosophy
Rice University
IOM (2001)
Johann Deisenhofer, Ph.D.
Regental Professor
The University of Texas Southwestern Medical Center
Nobel Laureate, NAS (1988, 1997)
Delores M. Etter, Ph.D.
TI Distinguished Chair in Engineering Education
Director, Caruth Institute for Engineering Education
Southern Methodist University
NAE (2000)
Ellen R. Gritz, Ph.D.
Professor and Chair, Department of Behavioral Science
Olla S. Stribling Distinguished Chair for Cancer Research
The University of Texas MD Anderson Cancer Center
IOM (2007)
Jan-Åke Gustafsson, M.D., Ph.D.
Robert A. Welch Professor, Department of Biology and
Biochemistry
University of Houston
NAS (2002)
Alan M. Lambowitz, Ph.D.
Professor and Director
Institute for Cellular and Molecular Biology
The University of Texas at Austin
NAS (2004)
James R. Lupski, M.D., Ph.D.
Cullen Professor of Molecular and Human Genetics
Professor of Pediatrics
Baylor College of Medicine
IOM (2002)
Kishor C. Mehta, Ph.D.
P. W. Horn Professor of Civil Engineering
Texas Tech University
Program Director, National Science Foundation
NAE (2004)
Frederick A. Murphy, DVM., Ph.D.
James W. McLaughlin Professor
Department of Pathology
The University of Texas Medical Branch at Galveston
IOM (1999)
Amelie G. Ramirez, Dr.P.H., M.P.H.
Director of the Institute for Health Promotion Research
The University of Texas Health Science
Center at San Antonio
IOM (2007)
George L. Stegemeier, Ph.D.
President
GLS Engineering, Inc.
NAE (2001)
Ben G. Streetman, Ph.D.
Dula D. Cockrell Centennial Chair in Engineering
College of Engineering
The University of Texas at Austin
NAE (1987)

T A M E S T l E A D E R S h i P
Dr. Bruce A. Beutler
Nobel Prize in Physiology or Medicine,
2011 | The University of Texas
Southwestern Medical Center
Dr. Michael S. Brown
Nobel Prize in Physiology or Medicine,
1985 | The University of Texas
Southwestern Medical Center
TAMEST Founding Co-Chairman
Dr. Robert F. Curl
Nobel Prize in Chemistry, 1996 |
Rice University
Dr. Johann Deisenhofer
Nobel Prize in Chemistry, 1988 |
The University of Texas Southwestern
Medical Center
Dr. Alfred G. Gilman
Nobel Prize in Physiology or Medicine,
1994 | Cancer Prevention and Research
Institute of Texas
Dr. Joseph L. Goldstein
Nobel Prize in Physiology or Medicine,
1985 | The University of Texas
Southwestern Medical Center
Dr. Dudley R. Herschbach
Nobel Prize in Chemistry, 1986 |
Texas A&M University
Dr. Russell A. Hulse
Nobel Prize in Physics, 1993 |
The University of Texas at Dallas
Dr. David M. Lee
Nobel Prize in Physics, 1996 |
Texas A&M University
Dr. Steven Weinberg
Nobel Prize in Physics, 1979 |
The University of Texas at Austin
Co-Chairmen
Ernest H. Cockrell
Chairman | Cockrell Interests Inc.
Michael S. Dell
Chairman of the Board and CEO | Dell,
Inc.
Thomas J. Engibous
Retired Chairman |Texas Instruments
Incorporated
Members
James F. Berry
President | Lockheed Martin Missiles and Fire Control
Dr. Peter T. Flawn
President Emeritus | The University of
Texas at Austin
John L. Garrison, Jr.
President and CEO | Bell Helicopter,
A Textron Company
Dr. Malcolm Gillis
Past President and University
Professor | Rice University
James T. Hackett
Chairman and CEO | Anadarko
Petroleum Corporation
Ralph D. Heath
Executive Vice President—Aeronautics
| Lockheed Martin Corporation
William P. Hobby
Former Lieutenant Governor of Texas
Kenneth M. Jastrow II
Retired Chairman and CEO | Temple-
Inland Inc.
Dr. Neal F. Lane
Malcolm Gillis University Professor |
Senior Fellow, James A. Baker III
Institute for Public Policy | Rice
University
Mark Mays
Chairman and CEO | Clear Channel
Communications
Paul B. Murphy, Jr.
President and CEO | Community
Bancorp LLC
Peter O’Donnell, Jr.
Chairman of the Board | O’Donnell
Foundation
Sara N. Ortwein
President | ExxonMobil Upstream
Research Company
Kurt Swogger
Chief Executive Officer | Designed
Nanotubes, LLC
Charles W. Tate
Chairman and Founding Partner |
Capital Royalty, L.P.
Dr. James J. Truchard
Co-Founder, President and CEO |
National Instruments
James R. Von Ehr II
President | Zyvex Labs
Pete Winstead
Founding Shareholder | Winstead PC
H. Bartell Zachry
Chairman of the Board | Zachry Group,
Inc.

T A M E S T u P c O M i N G E V E N T S
2 0 1 2 c r i t i c a l i s s u e s F o r u m
2 0 1 3 A n n u a l c o n f e r e n c e

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| Austin, Texas 78701 | www.tamest.org
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