Emerging Technologies for Healthier Living
King Lun Yeung
The Hong Kong University of Science and Technology
Ph.D. in Chemical Engineering
University of Notre Dame
K.L. Yeung
Associate Dean, School of Engineering
Professor, CBME & Div. of Environment, HKUST
Functional materials and nanomaterials for application in health and environment
Editor of Chemical Engineering Journal;
Scientific and editorial board member of international journals and conferences;
More than 150 publications, More than 300 conference papers; 50 plenary, keynotes and
invited talks.
11 Inventions with 30+ patents.
Grant reviewer for UK-EPSRC, European-ERC/Framework6/7, Singapore-A Star
U.S.-Small Business/Petroleum Research Fund
2
3
Hong Kong
1997
H5N1
2003
SARS
2009
H1N1
4
5
Cell toxicity and inflammatory test for encapsulated ClO2 coating
Safety Study
In-vitro and in-vivo
Nontoxic to the A549
human lung cells
1 2
3 4
10
Blood
1
1
2
2
3
25
Leukocyte cells (109/L)
2h
1h
3
a
8
20
6
15
4
10
2
5
ClO2
25
Negative
control
20
8
15
6
10
4
5
2
ClO2
Negative
control
Lung
20
c
4
15
3
10
2
5
1
ClO2
110
5
Blood
24 h
Lung
b
0
Negative
control
2h
10
Blood
0
Neutrophile cells (109/L)
1h
25
Lung
Lymphocyte cells (109/L)
30
Lung Function (FEV0.2/FVC, %)
1 2
3 4
DO NOT cause inflammatory response
from the A549 human lung cells
d
100
90
80
70
0
Negative
control
ClO2
Negative
control
ClO2
Negative
control
Negative
control
ClO2
ClO2
7
Field Test
Public Hospitals
Efficacy, operation, safety, use, application,
MDRO management.
8
1. Item surface – Stickiness/Oiliness
Questionnaire User Experience
Overall result
Clinical Study
More sticky / oily
(Worse)
Less sticky / oily
(Better)
As usual
          
-5
-4
-3
-2
-1
0
1
2
3
Worse
Willingness to use
In future
HH Practice
OVERALL FEELING
Smell on Hand
Skin roughness
Oiliness on skin
Appearance
Smell
Control
Item Surface
Smoothness
Intervention
Item Surface
Stick/Oiliness
Better
4
5
September 9, 2010 Press Conference
10
Safety Study
In-vitro and in-vivo
Efficacy
Laboratory and field
Antimicrobial Filters
a
b
uncoated
coated
b
a
uncoated
coated
Uncoated
uncoated
coated
Coated
14
Antimicrobial Filters
a
b
uncoated
coated
b
a
uncoated
coated
uncoated
coated
15
Waterborne Microbes
According to World Health Organization
(WHO), over 2 billion cases of illnesses are
caused by drinking unclean water. Microbial
contaminations of drinking water are known to
occur in municipal water supply network and
in building water distribution system. Many
microorganisms including known waterborne
pathogens (e.g., Legionella pneumophila,
Pseudomonas aeruginosa, Aeromonas sp
and Mycobacterium sp) not only survive but
thrive in building water system. The discovery
of Legionella pneumophila in the water from
the taps of the Hong Kong’s brand new
government headquarters illustrates the
gravity of the situation and its potential threat
to public health.
16
Clean Water
Micro-Mini Pulsed Electric Field
E. Coli Reduction (%)
100
80
60
40
20
1. Bacteria exposed to
PEF
3. Cell
inactivation
2. Cytoplasm
leaking
0
0
5
10
15
Time (min)
20
25
17
Acknowledgement
Graduate and undergraduate students
Dr. Dominic Tsang, Dr. Christopher Lai, Dr. Bosco Lam
RGC, ITF, French Consulate of Hong Kong and Macao, Veolia Waters
18