RESEARCH EXPERIENCE FOR UNDERGRADUATES AT THE UNIVERSITY OF PITTSBURGH DEPARTMENT OF CHEMICAL AND PETROLEUM ENGINEERING Mohammad M. Ataai*, Gerald D. Holder, and Robert F. Toplak Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, PA 15261 Summary Introduction We have served as a National Science Foundationsupported Research Experience for Undergraduates (REU) site, which supports 15 summer interns, since the summer of 1994. Each year, several additional students, supported by other means including departmental support and REU supplements, were also incorporated into the program. The program has planned many social activities: group lunches, picnics, visits to museums and entertainment parks, and athletic activities. These activities were designed to permit frequent, informal faculty-student and student-student interactions, provide opportunities for leisure and recreation, and, overall, help make the students' summer experience a pleasant one. Since inception, the retention has been 100%, as all the students who entered the program completed their internship. The program has maintained high academic standards as well as a high representation of minorities (29%) and females (47%) in the program. Student participants are followed post-program to provide documentation of their pursuit of advanced degrees, and career choices. A large proportion (70%) of the students in our program who have completed their undergraduate degree have entered graduate programs and medical schools. We have recruited heavily from a great number of colleges and universities in and around the Western Pennsylvania region, from Historically Black Colleges and Universities (HBCUs), and enrolled a large number (46%) of outstanding students from primarily undergraduate institutions. The recruitment efforts have been extremely successful. For example, for each year of the program, we received well over 100 applications and were forced to deny many excellent students with QPAs of 3.5/4.0 or higher from major colleges and universities. Our acceptance rate was also very high. Typically, 16-17 students were offered a position of which 15 accepted. We feel that the high percentage of acceptance of the positions can not only be due to our efforts in recruiting, but it reflects the popularity of the REU programs among the undergraduate students. Thus, national efforts should be directed to fund more of these programs and thus provide opportunities for a larger number of interested students to participate. Finally, the advisor selection process proved very effective. Out of a total of about 75 students enrolled in the program thus far, only one student was unsatisfied with the initial selection of a faculty mentor, this issue was identified and resolved in the first week by changing the advisor. *Corresponding Author Currently most undergraduates acquire their learning of a particular field through structured courses and labs. While these vehicles are essential, engaging in independent research in key technical problems would be both beneficial and motivational. The experience should help the students to appreciate the need for a comprehensive education with sufficient depth and breadth, and to make more informed decisions about the remainder of their undergraduate courses as well as graduate education and career options. An important issue is how to prepare students to begin a new experiment or engage in examining the feasibility of a new project. This is the key challenge the students will actually encounter in essentially any working environment, independent of their particular discipline (eg. law, finance, sciences and engineering). Our philosophy is that a more experiential exercise in the form of an undergraduate research project, as opposed to relying solely on traditional lectures and handouts, in research active laboratories should facilitate the following. (1) Broad exposure to various aspects of a practical problem. This will foster ‘Discovery’ and hypothesis formulation activities and could increase satisfaction students get from their education and stimulate them to continue working on other related exploratory projects. (2) Increased exposure to modern instrumentation and techniques useful in engineering, sciences, and medicine. (3) Emphasis on skills such as motivation, and team work. communication, Aim 1 is facilitated by communicating to the faculty members interested in supervising the undergraduate students, that the intention of our program is to engage students in somewhat independent and exploratory research projects rather than assigning them routine and repetitious applications of a particular technique for data collection. The project should have components enabling the student to take some intellectual ownership of the outcome of his/her work. Faculty members are also asked to consider the level of experience of the students as well as the relatively short period of their residency (about 10 weeks) in defining their project. Aim 2 is easier to achieve. Most of our research laboratories are well equipped. Students do get a broad exposure to modern instrumentation through their own projects and other on-going activities in the laboratories they are working in, as well as the projects in other laboratories where their fellow REU students conduct their research. Our final goal (Aim 3) is to emphasize the importance of oral and written communication skills. Although, we sponsor a workshop on presentation and communication skills, the goal is not to provide for extensive training in these areas, but to highlight their importance to the student’s future career. This aim is pursued through several venues including writing a project summary, a full 10 page description of their project (written in a manuscript form), and poster and oral presentations. Based on these activities, potential deficiencies in communication skills along with suggestions for improvement are communicated to the students. Program Our REU site has enrolled 15 undergraduate students for ten weeks in each of the last four years. Special emphasis has been placed on recruiting women and members of underrepresented minority groups. In addition to hands-on experimentation, the program incorporated workshops in several topic areas including laboratory safety, library and information resources, data analysis, research integrity, presentation and communication skills, graduate education opportunities, as well as tours of industrial laboratories. Other components of the program include various informal social activities, faculty mentoring, and a culminating undergraduate research symposium. We are following participants for a period of several years post-program to document their pursuit of advanced degrees, and career choices. Next, various aspects of the program are described in detail Emphasis on Students from Primarily Undergraduate Institutions Generally, the students from primarily undergraduate schools have fewer opportunities for conducting research than those in major research universities. There are many gifted students in primarily undergraduate colleges and universities who will benefit enormously from the REU program. Thus, we strongly feel that most REU sites in major research universities should recruit from such institutions. Our program has actively recruited from a number of colleges and universities in and around the Western Pennsylvania region. We are fortunate that, because of historical reasons, there are dozens of colleges and universities within a 100-mile radius of the University of Pittsburgh. The majority of these institutions do not have programs in engineering, but have strong programs in chemistry and biology. Fortunately, many of the projects offered by our faculty members are in the areas of biotechnology and catalysis/reaction engineering both well- suited to pursuit by undergraduates majoring in biological sciences and chemistry, respectively. Application and Selection Procedures Each applicant is required to submit a completed application form, a copy of their most recent academic transcript, one letter of recommendation from a faculty member at their institution, and a one-page statement of their career goals and interests by March 15 of the program year for which application is made. An application packet containing these documents is assembled for each applicant and reviewed by the PI and the Co-PI. Applicants are accepted to the program based on their academic credentials, strength of the recommendation letter, congruence of their career goals and interests with the content of the program, and their contribution to the desired "mix" of participants in terms of male/female representation, research university/small college or university, disabled/non-disabled, underrepresented minority/non-minority. Applicants are informed of the acceptance decision no later than mid-April. To increase our competitive position, some of the truly outstanding applicants were made offers as we received their completed applications. Titles of Selected Research Projects Below is a partial list of the projects that have been offered to the REU students. A majority of the projects are in the areas of Biochemical/Biomedical Engineering and Catalysis; both are very strong areas of research in our department. x Modeling the Interactions Between Free Polymers and Tethered Polymers in Solution Using the Monte Carlo Method (Anna Balazs, faculty advisor) x Physical Aging of Polyetherimide (Sindee Simon, faculty advisor) x Adhesion of Ultrasound Contrast Media in Human Endothelial Cells (William Wagner, faculty advisor) x Emission Testing and Evaluation of Natural Gas Vehicles (James T. Cobb, Jr., faculty advisor) x Assessment of Self-heating Property of Powdered Solids (George Klinzing, faculty advisor) x Modeling High Pressure Ammonia-Water Systems for Kalina Cycle Design ( Robert Enick, faculty advisor) x Evaluation of Lewis Acid Strength of Catalyst (Dan Farcasiu, faculty advisor) x Ultra-Violet Light Polymerization of Water-Soluble Polyethylene Glycol (PEG) Molecules to Synthesize Hydrogels (Alan Russell, faculty advisor) x Bleach Resistant Enzymes in Nerve Agent Detoxification (Alan Russell, faculty advisor) x Effects of Pulsatility on the Pressure Drop Prediction Across Aortopulmonary Shunts Using Modified Bernoulli Equation (Edward Cape, faculty advisor) x Selection of 15mer Peptide Affinity Ligands for Immobilized Metals (Mohammad Ataai, faculty advisor) x Synthesis of CO2-Philic Affinity Ligands for the Extraction of Proteins into Supercritical Carbon Dioxide (E.J. Beckman, faculty advisor) x Reactive Mapping of Promoted Catalysts (James G. Goodwin, Jr., faculty advisor) x Development of New Catalysts for Use in High Temperatures: Applications to Catalytic Combustors (George Marcelin, faculty advisor) x Reactions Of Organic Materials With Solid Superacids (Irving Wender, advisor) x Thermodynamics of Gas Hydrates (Gerald Holder, faculty advisor) Recruitment Plans Recruitment has focused on primarily undergraduate institutions in Western Pennsylvania, Historically Black Colleges and Universities (HBCUs), and to a lesser extent Ph.D. granting institutions. Target schools, as well as Chemical Engineering Departments throughout the country, receive a poster with postage paid response cards which provide a means for interested students to request application materials and also for promotion of the REU program. Colleges and Universities visited by our faculty, specifically for REU recruitment, include: Clark Atlanta University, California University of Pennsylvania, Emory University, Morehouse College, Syracuse University, Lehman College, Long Island University, Brooklyn College (CUNY), Morris Brown College, Spelman College, Hampton University, North Carolina A&T State University, and Norfolk State University. In some of these trips Dr. Carla Gary, Associate Dean for Minority Affairs, has accompanied our faculty members and helped us to more effectively recruit from these institutions. In addition to the specific REU recruitment trips, faculty who are invited to make research presentations in other universities are supplied with the REU program materials and asked to meet with undergraduate coordinators, identify highly qualified REU applicants, and if possible make an REU presentation to undergraduates. This approach allows us to take advantage of the faculty member’s time, and limits the expense that would have been incurred if the PI had made individual recruiting visits for the REU program. Advisor Selection Participants were asked to select their top three choices of projects from descriptions provided to them with the application form. The students' selections of research projects in 1994 (the first year of our program) were made prior to the student’s arrival. This was done to minimize the time spent on this issue. While almost all students felt comfortable/satisfied with the projects selected for them in the 1994 program, they also felt that they would have preferred to choose their individual projects. The process of advisor selection was modified to allow for the selection of advisor/project directly by the students. It was modeled after the Department's graduate student advisor selection process. Students receive background information on the faculty and available research projects prior to their arrival. Upon arrival students meet with faculty to discuss available projects and then make their final selections at the end of the second day. While the selection period is short and the PI and Administrator have had to resolve a few conflicting selections, the process was well received by 1995, 1996, and 1997 REU participants. The process not only allowed students to be involved with the selection process, but also served to facilitate interaction among faculty and students early in the program. Student Activities A variety of activities that were integral or supplemental to the total program took place throughout the ten-week program period. These activities were designed to provide for additional faculty-student and student-student interactions, impart useful information or new career vistas to the students, and serve as social outlets for both faculty and student participants. To permit students to take advantage of the many academic, social, and recreational resources offered at the University, each student participant was issued a special University identification card that allowed access to libraries, sports facilities and campus transportation. Moreover, to facilitate communication among students, faculty, and the PIs, each student was assigned an Electronic Mail Address on the first day of the program and the master Email list was then distributed to every one associated with the program. A seminar series (see Table 1) was scheduled over the course of the program to enhance the participants research experience while social activities, such as pizza lunches (after each seminar) and departmental picnics, permitted frequent informal faculty-student and student-student interactions, provided opportunities for leisure and recreation, and, overall, helped make the students' summer experience a pleasant one. At the departmental picnic, held twice each Summer, faculty members, students, and department staff brought food reflective of their national or ethnic origins. Furthermore, a Summer Research Consortium Dinner and Poster Session was organized. This event, attended by many University officials including the Vice Provost for Research and the Dean of the Faculty of Arts and Sciences, provided the opportunity for students from all Summer undergraduate research programs at the University to become acquainted with their peers, faculty, and University officials. Finally, the Research Symposium in which participants presented the results of their research was attended by graduate student mentors, faculty advisors, and members of the local industrial community. Table 1. REU Seminars/Workshops -1996 Date June 1 June 7 June 14 June 21 June 30 July 11 July 12 July 19 July 26 August 2 Topic Orientation and Laboratory Safety Library and Computer Resources ChE Process Simulators Research Integrity Health and Safety Regulations Research Consortium Dinner Industrial R&D Laboratory Tour Presentation and Communication Skills Graduate Education Opportunities REU Student Research Symposium Program Assessment A questionnaire was developed to elicit feedback from the participants at the midpoint of the program and one month after the program's end (to allow time for students to reflect on their experience). The students were queried on social activities, housing, research project selection, seminars, and the program's influence on their future career paths. Responses were reviewed to identify student problems (midpoint), overall program strengths and deficiencies (program end), and to fine tune the program for the next Summer. Overwhelmingly participants indicated the most important aspects of the program were learning about research oriented careers and graduate school opportunities. Most students indicated that the program provided them with the insight to enable them to make an informed decision regarding graduate education. The follow-up survey (sent to graduating seniors at the end of April) provided information on the number of students who opted to pursue advanced degrees on the way to establishing careers in industry or academe. Currently about 70% of students in our program who have completed their undergraduate degree are attending Graduate or Medical School. Need For Increased Number of REU Sites The Response to the REU program at University of Pittsburgh has been enthusiastic. For example, requests for application forms for the Summer 1996 program exceeded 260, while complete applications returned numbered 83. Due to the high quality of applicants many students from major research universities and the primarily undergraduate institutions with high QPAs of 3.6/4.0 or somewhat higher were not offered a position in our program. Typically, each year 16-17 offers were made of which 15 were accepted. The retention was 100% in all three years. The high percentage of acceptance of the positions in the last several years can not only be attributed to our efforts in recruiting, but it demonstrates that the REU programs are popular among undergraduate students. Thus, we feel that national efforts should be directed to expand the number of these programs. Although we are not experts in the economics of different undergraduate research programs, we feel that the REU sites are extremely cost-efficient. An entire REU site of 15 students often costs about the same as training one graduate student on a research grant for one year. One reason for this low cost could be that costs are absorbed, directly or indirectly, by the universities and departments, as well as individual faculty members. That is, faculty members are not compensated specifically for their efforts in training REU students and supply money is typically not charged to the REU grant. Moreover, universities absorb at least part of, and in some cases the entire indirect costs associated with the program. Publications and Presentations A number of our students participated in the 1995 national meeting of the American Institute of Chemical Engineers (AIChE) and presented their work in poster sessions. Moreover, they have contributed to a large number of peer reviewed manuscripts. Their publications and presentations are listed below. The following papers and presentations include REU participants (in bold) from 1994, 1995, and 1996 as coauthors. Cobb, J., Neufeld, R., Schreiber, E., Clifford, B., Pritts, J., Agostini, J., Spencer, S., Beeghly, J., Bender, C., Quarterly Technical Progress Report to U.S. Department of Energy - Morgantown Energy Technology Center, "Treatment of Metal-Laden Hazardous Wastes with Advanced Clean Coal Technology By-Products", July, 1997. Chaudhary, A., Lopez, J., Beckman, E.J. and Russell, A.J. (1997) Biotechnol. Prog., 13 (3), 318-325. “Biocatalytic and Solvent-free Polymerization to Produce High Molecular Weight Polyesters.” LeJeune, K.E., Mesiano, A., Bower, S., Grinsley, J.K., Wild, J.R. and Russell, A.J. (1997) Biotechnol. Bioengin. 54 (2), 105-114. “Dramatically Stabilized Phosphotriesterase-polymers for Nerve Agent Degredation.” Andreopoulos, F.M., Deible, C.R., Stauffer, M.T., Weber, S.G., Wagner, W.R., Beckman, E.J. and Russell, A.J. (1996) J. Amer. Chem. Soc., 118:26, 6235-6240. “Photoscissable Hydrogel Synthesis Via Rapid Photopolymerization of Novel PEG-based Polymers in the Absence of Photoinitiators.” Andreopoulos, F.M., Deible, C.R., Stauffer, M.T., Weber, S.G., Wagner, W.R., Beckman, E.J. and Russell, A.J. (1996) abstract from Tissue Engineering Society, Annual Meeting (December), Orlando, FL. “Photoscissable Biocompatible Hydrogel Synthesis and Utilization for Prevention of Platelet Deposition.” Deible, C.R., Lydic, A.M., Beckman, E.J. and Russell, A.J. (1996) abstract from AIChE, Annual Meeting (November), Chicago, IL. 57i. “Reducing Platelet Deposition onto Damaged Arteries with Covalently Attached Polyethylene Glycol.” Rilo, H.L.R., Diaf, A., Beckman, E., Deible, C., Russell, A.J., Byrne, M.E., Rao, A.S. and Wagner, W.R. “Microencapsulation of Isolated Pancreatic Islets with Photocrosslinkable Polyethylene Glycol-based Polymers,” Fifth IPITA Congress, Miami, FL, June 1995. Yang, Z., Mesiano, A.J., Venkatasubramanian, S., Harris, J.M., Gross, S.H. and Russell, A.J. (1995) J. Amer. Chem. Soc., 117, 17, 4843-4850. "Activity and Stability of Subtilisin Incorporated into Acrylic Polymers". Kogelbauer, A., Reddick, J., and Farcasiu, D. (1995) abstract from 14th North American Meeting of The Catalysis Society, June 11-16, Snowbird, Utah, "Mechanistic Study of the Acid Catalyzed Formation and Hydrolysis of MTBE in Non-polar Media" Yang, F., Ledenbach, L., and Russell, A.J. (1994) abstract from Scientific Conference on Chemical and Biological Defense Research (November), Edgewood, MD. "Enzymatic Degradation of Pesticides in a Continuous Gas Reactor". Komives, C., Osborne, D. and Russell, A.J. (1994) Biotechnol. Prog., 10,340-343, "Degredation of Pesticides in a Continuous-flow Two-phase Microemulsion Reactor". Komives, C., Lilley, E. and Russell, A.J. (1994) Biotechnol. Bioengin., 43, 946-959, "Biodegredation of Pesticides in Non-ionic Water-in-oil Microemulsions of Tween 85: Relationship Between Micelle Structure and Activity". Komives, C., Osborne, D. and Russell, A.J. (1994) J. Phys. Chem., 98;1,369-376, "Characterization of a non-ionic surfactant reversed micellar system for enzyme catalysis". Cobb, J., Neufeld, R., Schreiber, E., Clifford, B., Pritts, J., Agostini, J., Murray, C., Beeghly, J., Bender, C., Quarterly Technical Progress Report to U.S. Department of Energy - Morgantown Energy Technology Center, "Treatment of Metal-Laden Hazardous Wastes with Advanced Clean Coal Technology By-Products", November, 1995. Kogelbauer, A, Weber, J, Goodwin, J., "The Formation of Cobalt Silicates on Co/SiO2 Under Hydrothermal Conditions", Catalysis Letters, 34, 259-267,1995. A. Kogelbauer, J. Reddick, D. Farcasiu, "Mechanistic Study of the Acid Catalyzed Formation and Hydrolysis of MTBE in Nonpolar Media", J. Mol. Catal., 1995, 103, 31-41. Altland, B.L., Cox, D., Enick, R.M., Beckman, E.J., "Optimization of the High Pressure, Near-Critical LiquidBased Microsortation of Recyclable Post-Consumer Plastics", Resources, Conservation and Recycling, 15 (1995) 203-217. Vierheller, C.Z., Goel, A., Peterson, M., Domach, M.M., Ataai, M.M., "Sustained and Constitutive High Levels of Protein Production in Continuous Cultures of B. subtilis", Biotechnol. Bioeng., 47: 520-524 (1995). Kralovic G, Vanauker MD, Cape EG (1995) "An Analysis of Ventricular Septal Defects", Proceedings, National Meeting of American Institute of Chemical Engineers, November, paper 242.15as. Vanauker MD, Kralovic G, del Nido PJ, Tacy TA, Sigfusson G, Cape EG (1996) "Septal Shear Stress Elevation in Pediatric Heart Disease: Implications for Subaortic Stenosis. Proceedings, 15th Southern Biomedical Engineering Conference. Goel, A., Hanley, W., Domach, M.M., Ataai, M.M., "Elimination of Acid Formation in Fast Growing Bacterial Cultures", Annals. NY Acad. Sci., 782: 1-16, 1996. Ian Connor S. L. Simon, D. J. Plazek, B. J. Harper, and T. Holden, "Physical Aging of Polystyrene: Volume and Enthalpy Recovery", Polymer Materials Science and Engineering, 76, 334 (1997). "Interaction of albumin microbubbles with endothelial cells and their matrix", American Institute of Chemical Engineers Annual Meeting, Chicago, IL, November 1996. Talk Acknowledged Ian Connor. The following REU participants (in bold) received acknowledgement for their contributions in the following papers and presentations. "The effect of retroviral transduction on human endothelial cell phenotype", Inaugural Meeting of the Tissue Engineering Society, Orlando, FL, December 1996. Talk acknowledged Ian Connor. Genea Lee Hajdu, P.E., Tierney, J.W., Wender, I., paper entitled "Effect of Modifying Host Oil on Coprocessing" presented at ACS Division of Fuel Chemistry, Symposium on Coprocessing of Coal and Waste Materials in April 1995. Hajdu, P., Tierney, J., Wender, I., "Effect of Catalytic Hydropretreatment of Heavy Oil on Coal/Heavy Oil Coprocessing", Energy and Fuels, 10 (2), 493-503, 1996. Amand Lydic Deible CR, Beckman EJ, Russell AJ, Wagner WR: Covalently attached molecular barriers to thrombosis on damaged arteries. (submitted to J Biomat Res) acknowledges Amanda Lydic. "Reducing platelet deposition onto damaged arteries with covalently attached polyethylene glycol", American Institute of Chemical Engineers Annual Meeting, Chicago, IL, November 1996. talk acknowledged Amanda Lydic. "Covalent modification of damaged arterial tissue to reduce thrombosis", Inaugural Meeting of the Tissue Engineering Society, Orlando, FL, December 1996. Talk acknowledged Amanda Lydic. "Reducing thrombosis in synthetic microconduits by modifying surface proteins", Inaugural Meeting of the Tissue Engineering Society, Orlando, FL, December 1996. Talk acknowledged Amanda Lydic. Ryan Miller "Measuring temporal platelet deposition on opaque surfaces", American Institute of Chemical Engineers Annual Meeting, Chicago, IL, November 1996. Talk acknowledged Ryan Miller. The following REU Participants presented poster/papers at the AIChE 1995 Annual Meeting in Miami Beach, Florida. Alveda J. Finnell, Norfolk State University, Student Paper/Poster Competition, 1995 AIChE Annual Meeting, Miami Beach, Florida, Co-authored with Dr. James G. Goodwin, Jr., "Supported Cobalt Catalysts for HighTemperature Fischer-Tropsch Synthesis". Arthur D. Thomas, Bucknell University, Student Paper/Poster Competition, 1995 AIChE Annual Meeting, Miami Beach, Florida, Co-authored with Dr. William R. Wagner, "Photopolymerization of Polyethylene Glycol". Georgia Kralovic, University of Pittsburgh, Student Paper/Poster Competition, 1995 AIChE Annual Meeting, Miami Beach, Florida, Co-authored with Dr. Edward Cape, "Fluid Dynamic Analysis of Ventricular Septal Defects". The Following REU participants have submitted papers in response to the call for papers of the Rohm and Haas sponsored NOBCChE Undergraduate Research Paper Competition 1996. Chad Worth, North Carolina A&T State University, Coauthored with Dr. J. Karl Johnson, "Toward an Analytic Expression for the Radial Distribution Function". Alveda J. Finnell, Norfolk State University, Co-authored with Dr. James G. Goodwin, Jr., "Supported Cobalt Catalysts for High-Temperature Fischer-Tropsch Synthesis".