The University Of Western Ontario
Faculty of Engineering
DEPARTMENT OF CHEMICAL AND BIOCHEMICAL ENGINEERING
CBE 4404A - Downstream Processing in Pharmaceutical Manufacturing
Course Outline 2010-2011
Objectives
The objective of this course is to introduce upper year chemical/biochemical engineering
students to pharmaceutical manufacturing. An overview of the pharmaceutical industry and its
regulations will be presented followed by the basic concepts of the major manufacturing
methods and their component unit operations. Examples of the manufacturing of selected
pharmaceutical drugs will be presented.
Prerequisites
CBE 3322A/B, CBE 3323A/B, CBE 3324A/B, CBE 3325A/B.
Unless you have either the requisites for this course or written special permission from your
Dean to enroll in it, you will be removed from this course and it will be deleted from your
record. This decision may not be appealed. You will receive no adjustment to your fees in the
event that you are dropped from a course for failing to have the necessary prerequisites.
Corequisites
None
Antirequisites
None
Contact Hours
3 lecture hours, 1 tutorial hour, 0.5 course.
Instructor
Dr. L. Briens (TEB 449) Telephone: 519-661-2111 ext: 88849 email: lbriens@uwo.ca
Undergraduate Assistant
Marilyn Tudhope (TEB 477) Telephone: 519-661-2131 email: mtudhop@uwo.ca
Teaching Assistants
Ryan Logan, email: rlogan3@uwo.ca
Craig Mara, email: cmara@uwo.ca
CBE 4404A Course Outline
2
Required Texts
None
Course Notes
Course notes will be available for download from the course website.
Laboratory Notes
None
Reference Texts
None
Laboratory
None
Units
SI, FPS, and CGS units will be used.
General Learning Objectives
Knowledge Base
x
Individual Work
Problem Analysis
x
Team Work
Investigation
Design
Engineering Tools
x
x
x
Communication
Professionalism
Impact on Society
x
x
Ethics and Equity
Economics and Project
Management
Life-Long Learning
x
Specific Learning Objectives
1. Overview of the pharmaceutical industry
2. Regulations and Safety Issues
3. Mixing
a. Functions and characteristics of the components of pharmaceutical mixtures
b. Principles of mixing
c. Types of mixers
d. Monitoring mixing
4. Granulation
a. Dry granulation
b. Wet granulation
c. Oven drying
d. Fluid bed drying
e. Monitoring granulation and drying
x
x
CBE 4404A Course Outline
3
5. Tabletting
a. Functions and stages of the tablet compression process
b. Overview of tabletting equipment
c. Examination of dies and punches
6. Coating
a. Principles of coating
b. Coating materials
c. Spray coating
d. Fluid bed coating
7. Encapsulation
a. Manufacture of hard-shell capsules
b. Manufacture of soft gel capsules
8. New directions in pharmaceuticals
Evaluation
The final course mark will be determined as follows:
Assignments
15%
Project
35%
Final Examination
50%
Notes
1) Students must pass the final examination to pass this course. Students who fail the final
examination will be assigned 48% if the aggregate mark is more than 50% or the aggregate
mark.
2) Assignments are to be handed in electronically through WebCT/OWL. Late assignments will
receive a mark of zero.
3) For the project, each student will be assigned a pharmaceutical drug to investigate. The
project will include the drug history, drug use, drug effectiveness, potential drug side effects,
components of the drug and their functions and characteristics, and a proposed manufacturing
pathway with evaluation and preliminary design.
Repeating All Components of the Course
In accordance with Senate and Faculty Policy, students who have failed an Engineering course
(i.e. <50%) must repeat all components of the course. No special permissions will be granted
enabling a student to retain laboratory, assignment or test marks from previous years.
Previously completed assignments and laboratories cannot be resubmitted for grading by the
student in subsequent years.
Use of English
In accordance with Senate and Faculty Policy, students may be penalized up to 10% of the
marks on all assignments, tests, and examinations for the improper use of English. Additionally,
poorly written work with the exception of the final examination may be returned without
grading. If resubmission of the work is permitted, it may be graded with marks deducted for
poor English and/or late submission.
CBE 4404A Course Outline
4
Attendance
Attendance in all lectures, tutorials and laboratories is mandatory. Any student who, in the
opinion of the instructor, is absent too frequently from class or laboratory periods in any
course, will be reported to the Dean (after due warning has been given). On the
recommendation of the Department concerned, and with the permission of the Dean, the
student will be debarred from taking the regular examination in the course.
Cheating
University policy states that cheating is a scholastic offence. The commission of a scholastic
offence is attended by academic penalties, which might include expulsion from the program. If
you are caught cheating, there will be no second warning (see Scholastic Offence Policy in the
Western Academic Calendar).
Plagiarism
Students must write their essays and assignments in their own words. Whenever students take
an idea or a passage from another author, they must acknowledge their debt both by using
quotation marks where appropriate and by proper referencing such as footnotes or citations.
Plagiarism is a major academic offence (see Scholastic Offence Policy in the Western Academic
Calendar).
The University of Western Ontario has software for plagiarism checking. Students may be
required to submit their work in electronic form for plagiarism checking.
Conduct
Students are expected to arrive at lectures on time, and to conduct themselves during class in a
professional and respectful manner that is not disruptive to others.
Sickness and Other Problems
Students should immediately consult with the instructor or Department Chair if they have any
problems that could affect their performance in the course. Where appropriate, the problems
should be documented. The student should seek advice from the Instructor or Department
Chair regarding how best to deal with the problem. Failure to notify the Instructor or
Department Chair immediately (or as soon as possible thereafter) will have a negative effect on
any appeal.
Please contact the course instructor if you require material in an alternate format or if any
other arrangements can make this course more accessible to you. You may also wish to contact
Services for Students with Disabilities (SSD) at 661-2111 x 82147 for any specific question
regarding an accommodation.
Notice
Students are responsible for regularly checking their Western email and notices posted on
Instructors' doors.
CBE 4404A Course Outline
Consultation
Students are encouraged to discuss problems with their teaching assistant and/or instructor in
tutorial sessions. Office hours will be arranged for the students to see the instructor and
teaching assistants. Other individual consultation can be arranged by appointment with the
appropriate instructor.
Accreditation (AU) Breakdown
Engineering Science =
60%
Engineering Design =
40%
September 8, 2010 / af
5
The University of Western Ontario
Faculty of Engineering
DEPARTMENT OF CHEMICAL AND BIOCHEMICAL ENGINEERING
CBE 4407A - Solid Waste Treatment
Course Outline for 2010-2011
Description
This course covers principles of solid waste treatment using chemical and biological methods, with
emphasis on waste volume reduction at the source and recycling. Classification of solid wastes,
incineration, fluidized chemical reactors and bioreactors for solid waste treatment, chemical and
biological oxidation of solids, chemical and biological treatment of hazardous compounds in soil.
Prerequisites
CBE 3323A/B, CBE 2220A/B, CBE 3301A/B, CBE 3315A/B or GPE 3315A/B, CBE 3322A/B or GPE
3322A/B, CBE 3325A/B.
Unless you have either the requisites for this course or written special permission from your Dean to
enroll in it, you may be removed from this course and it will be deleted from your record. This
decision may not be appealed. You will receive no adjustment to your fees in the event that you are
dropped from a course for failing to have the necessary prerequisites.
Corequisite
None
Antirequisite
None
Contact Hours
3 lecture hours, 1 tutorial hour, 0.5 course.
Instructor
Dr. M. Ray (TEB 443) Telephone: 519-661-2111 ext: 81273 email: mbhowmic@uwo.ca
Undergraduate Assistant
Marilyn Tudhope (TEB 477) Telephone: 519-661-2131 email: mtudhop@uwo.ca
Teaching Assistants
Rifath Sharmin, email: rsharmi@uwo.ca
Required Text
None
Course Notes
Course notes will be available for download from the course website or provided by the Instructor.
CBE 4407A Course Outline
2
Lab Notes
None
References Texts
Handbook of Solid Waste Management, 2nd edition, George Tchobanoglous and Frank Kreith, 2nd
edition, McGraw-Hill, 2002.
Solid Waste Engineering, P. A. Vesilind, W. A. Worrell and D. R. Reinhart, Thomson Learning, 2002.
General Learning Objectives
Knowledge Base
X
Individual Work
Problem Analysis
X
Team Work
Investigation
Design
Engineering Tools
X
X
X
Communication
Professionalism
Impact on Society
X
X
X
X
Ethics and Equity
Economics and Project
Management
Life-Long Learning
X
X
X
Topics
• Integrated solid waste management
• Sources and classification of solid wastes
• Refuse collection systems
• Processing of solid waste
• Materials separation
• Combustion and energy recovery
• Design principles of fluidized and non-fluidized incinerator reactors
• Biological and enzymatic kinetics of solid waste biodegradation and bio-oxidation
• Current issues in solid waste management
Evaluation
The final mark will be calculated as follows:
Assignments
30%
Midterm
30%
Final exam
40%
The final examination will be closed book.
Note
1. Students must pass the final examination to pass this course. Students who fail the final
examination will be assigned 48% if the aggregate mark is higher than 50%, or the aggregate
mark.
2. Assignments are to be handed into the CBE 4407A locker (#464) in TEB on the specified due
date provided by the Instructor.
CBE 4407A Course Outline
3
Repeating All Components of the Course
In accordance with Senate and Faculty Policy, students who have failed an Engineering course (i.e.
<50%) must repeat all components of the course. No special permissions will be granted enabling a
student to retain laboratory, assignment or test marks from previous years. Previously completed
assignments and laboratories cannot be resubmitted for grading by the student in subsequent years.
Use of English
In accordance with Senate and Faculty Policy, students may be penalized up to 10% of the marks on
all assignments, tests and examinations for the improper use of English. Additionally, poorly written
work with the exception of final examinations may be returned without grading. If resubmission of
the work is permitted, it may be graded with marks deducted for poor English and/or late submission.
Attendance
Any student who, in the opinion of the instructor, is absent too frequently from class or laboratory
periods in any course, will be reported to the Dean (after due warning has been given). On the
recommendation of the Department concerned, and with the permission of the Dean, the student
will be debarred from taking the regular examination in the course.
Cheating
University policy states that cheating is a scholastic offence. The commission of a scholastic offence
is attended by academic penalties, which might include expulsion from the program. If you are
caught cheating, there will be no second warning (see Scholastic Offence Policy in the Western
Academic Calendar).
Plagiarism
Students must write their essays and assignments in their own words. Whenever students take an
idea or a passage from another author, they must acknowledge their debt both by using quotation
marks where appropriate and by proper referencing such as footnotes or citations. Plagiarism is a
major academic offence (see Scholastic Offence Policy in the Western Academic Calendar).
The University of Western Ontario has software for plagiarism checking. Students may be required to
submit their work in electronic form for plagiarism checking.
Conduct
Students are expected to arrive at lectures on time, and to conduct themselves during class in a
professional and respectful manner that is not disruptive to others.
Sickness and Other Problems
Students should immediately consult with the instructor or Department Chair if they have any
problems that could affect their performance in the course. Where appropriate, the problems should
be documented. The student should seek advice from the Instructor or Department Chair regarding
how best to deal with the problem. Failure to notify the Instructor or Department Chair immediately
(or as soon as possible thereafter) will have a negative effect on any appeal.
CBE 4407A Course Outline
4
Please contact the course instructor if you require material in an alternate format or if any other
arrangements can make this course more accessible to you. You may also wish to contact Services for
Students with Disabilities (SSD) at 661-2111 x 82147 for any specific question regarding an
accommodation.
Notice
Students are responsible for regularly checking their Western email and notices posted on
Instructors' doors.
Consultation
Students are encouraged to discuss problems with their teaching assistant and/or instructor in
tutorial sessions. Office hours will be arranged for the students to see the instructor and teaching
assistants. Other individual consultation can be arranged by appointment with the appropriate
instructor.
Accreditation (AU) Breakdown
Engineering Science = 50%
Engineering Design = 50%
September 8, 2010 / af
The University of Western Ontario
Faculty of Engineering
DEPARTMENT OF CHEMICAL AND BIOCHEMICAL ENGINEERING
CBE 4415 - CHEMICAL ENGINEERING PROJECT
Course Outline 2010-2011
Description
Selection and investigation of an engineering problem. Analytical and/or experimental work is
carried out by individual students or project groups under the supervision of a faculty member.
Progress reports and a final engineering report are prepared; each student must deliver a public
lecture.
Prerequisites
Completion of third year of the Chemical Engineering program.
Unless you have either the requisites for this course or written special permission from your
Dean to enroll in it, you may be removed from this course and it will be deleted from your
record. This decision may not be appealed. You will receive no adjustment to your fees in the
event that you are dropped from a course for failing to have the necessary prerequisites.
Corequisites
None
Antirequisites
None
Contact Hours
As determined by the individual advisor.
Instructor
Dr. W. Wan (TEB 433) Telephone: 519-661-2111 ext. 88440 email: wkwan@uwo.ca
Undergraduate Assistant
Marilyn Tudhope (TEB 477) Telephone: 519-661-2131 email: mtudhop@uwo.ca
Required Texts
Given the versatility of the projects involved, there is no single textbook which can cover all the
course material. Selected textbooks and other references are suggested by the advisor and the
course coordinator on an individual basis.
CBE 4415 Course Outline
2
Course Notes
None
Laboratory Notes
None
Reference Texts
Reference texts will be suggested by the advisor and the course coordinator on an individual
basis. In addition, the following is suggested to all students:
L. Finkelstein, Jr. Pocket Book of Technical Writing for Engineers and Scientists. McGraw Hill,
Toronto. 2000.
Laboratory
6 laboratory hours, 1.0 course.
Units
SI units and as appropriate for each individual project.
General Learning Objectives
Knowledge Base
X
Individual Work
Problem Analysis
X
Team Work
Investigation
Design
Engineering Tools
X
X
X
Communication
Professionalism
Impact on Society
X
X
X
X
Ethics and Equity
Economics and Project
Management
Life-Long Learning
X
X
X
Specific Learning Objectives
At the end of this topic, students should be able to:
• Define and devise an approach to solve a chemical engineering problem.
• Search and review the literature to help develop a plan to solve the problem.
• Acquire the computational or experimental skills required to solve the problem.
• Acquire oral communication skills. Students are required to give an oral presentation to a
panel of examiners.
• Acquire written communication skills. Students are required to submit a proposal, a
progress report, an abstract for the oral presentation and a final formal report.
Evaluation
The final course mark will be determined as follows:
Proposal
5%
Progress report
5%
Abstract for oral presentation
5%
Oral presentation
20%
CBE 4415 Course Outline
Formal report
3
65%
The oral presentation will be given to a panel of examiners. The oral presentation mark will be
an average of the marks given by the panel of examiners. All other marks are the responsibility
of the individual advisor.
Due dates are as follows:
Proposal
Progress report
Abstract
4th Year Presentation Days
Formal report
October 19, 2009
January 5, 2010
March 22, 2010
March 25, 2010
April 6, 2010
Students must turn in all laboratory reports, and achieve a passing grade in the laboratory
component, to pass this course.
Use of English
In accordance with Senate and Faculty Policy, students may be penalized up to 10% of the
marks on all assignments, tests, and examinations for the improper use of English. Additionally,
poorly written work with the exception of the final examination may be returned without
grading. If resubmission of the work is permitted, it may be graded with marks deducted for
poor English and/or late submission.
Attendance
Any student who, in the opinion of the instructor, is absent too frequently from class or
laboratory periods in any course, will be reported to the Dean (after due warning has been
given). On the recommendation of the Department concerned, and with the permission of the
Dean, the student will be debarred from taking the regular examination in the course.
Cheating
University policy states that cheating is a scholastic offence. The commission of a scholastic
offence is attended by academic penalties, which might include expulsion from the program. If
you are caught cheating, there will be no second warning (see Scholastic Offence Policy in the
Western Academic Calendar).
Plagiarism
Students must write their essays and assignments in their own words. Whenever students take
an idea or a passage from another author, they must acknowledge their debt both by using
quotation marks where appropriate and by proper referencing such as footnotes or citations.
Plagiarism is a major academic offence (see Scholastic Offence Policy in the Western Academic
Calendar).
The University of Western Ontario has software for plagiarism checking. Students may be
required to submit their work in electronic form for plagiarism checking.
CBE 4415 Course Outline
4
Conduct:
Students are expected to arrive at lectures on time, and to conduct themselves during class in a
professional and respectful manner that is not disruptive to others.
Sickness and Other Problems
Students should immediately consult with the instructor or Department Chair if they have any
problems that could affect their performance in the course. Where appropriate, the problems
should be documented. The student should seek advice from the Instructor or Department
Chair regarding how best to deal with the problem. Failure to notify the Instructor or
Department Chair immediately (or as soon as possible thereafter) will have a negative effect on
any appeal.
Please contact the course instructor if you require material in an alternate format or if any
other arrangements can make this course more accessible to you. You may also wish to contact
Services for Students with Disabilities (SSD) at 661-2111 x 82147 for any specific question
regarding an accommodation.
Notice
Students are responsible for regularly checking their Western email and notices posted on
Instructors' doors.
Consultation
Students are encouraged to discuss problems with their teaching assistant and/or instructor in
tutorial sessions. Office hours will be arranged for the students to see the instructor and
teaching assistants. Other individual consultation can be arranged by appointment with the
appropriate instructor.
Accreditation (AU) Breakdown
Complementary Studies = 25%
Engineering Science
= 50%
Engineering Design
= 25%
CBE 4415 REPORT REQUIREMENTS
Proposal
The proposal should not be more than two pages long and contain the following sections:
Introduction
to provide the background information.
Objectives
to outline the proposed project and the objectives.
Methodology
to lay down the technical approaches to be employed in solving the
problems, including the proposed experiments/simulations,
experimental apparatus, analytical methods, data processing, etc.
Milestones
to provide a list of important tasks and the anticipated completion
date.
CBE 4415 Course Outline
5
Progress Report
The progress report must:
• Summarize the progress made since the start of the project.
• Using the task list presented in the proposal, report on the progress of each task.
• Discuss any outstanding problem and plans for its resolution.
• Highlight and justify any deviation from the original plan.
• Provide an updated plan and task list.
The progress report, including references, should not be longer than ten pages.
Informative Abstract
The abstract should contain no more than 200 words, and summarize the most important aspect of your
project including the objectives, the methodology, results, discussions and conclusions.
Final Report
This should be a formal technical report, conforming to the usual requirements for a standard technical
report. The suggest sections include:
-
Title, Table of contents, Lists of Figures and Tables.
Acknowledgements
Introduction
Project Outline and Objectives
Theory (if appropriate)
Methodology
Experiment Apparatus
Experimental Procedures
Data Analysis
Computer simulation or model prediction (if any)
Results and discussions
Conclusions
Recommendations
Nomenclature
References
Appendix: calibration, raw data, computer program, etc.
CBE 4415 Course Outline
6
CBE 415
FINAL PROJECT REPORT
2 BOUND COPIES
DUE: To be determined
IN
ROOM TBA
PRINTING AND BINDING INSTRUCTIONS
(SEE BELOW):
COMMISSARY COPY CENTRE - GRAPHIC SERVICES
Saugeen-Maitland
(RECOMMENDED)
THEY WILL MAKE COPIES AND BIND YOUR REPORT
CBE 4415 Course Outline
7
HOURS: 8:00 a.m. - 8:00 p.m.
THIS IS AN EXAMPLE OF THE COVER
OF YOUR FINAL REPORT
TO BE PRINTED ON 'COUGAR WHITE' COVER STOCK
CLEAR COVER ON THE FRONT
COUGAR WHITE COVER STOCK ON THE BACK
WHITE BINDING ON THE SIDES
The University of Western Ontario
Faculty of Engineering
'TITLE OF PROJECT'
by
'Student's Name'
Department of Chemical and Biochemical Engineering
CBE 4415 - Chemical and Biochemical Engineering
Project Report
In partial fulfillment of the requirements for the degree
CBE 4415 Course Outline
8
of
Bachelor of Engineering
Date:
Faculty Advisor:
The University of Western Ontario
Faculty of Engineering
DEPARTMENT OF CHEMICAL AND BIOCHEMICAL ENGINEERING
CBE 4421A – Biomaterials Engineering
Course Outline 2010-2011
Description
Biomaterials engineering includes elements of medicine, biology, chemistry, physics, and
materials and chemical engineering. It can be applied for almost every part of biomedicaldevice design. This course aims at the integration of fundamental-processing-application. Three
major topics are: 1) fundamental biomaterials and biocompatible; 2) Biomaterials
manufacturing and characterization; and 3) application of biomaterials in artificial organs,
dental implant, ophthalmologic applications, etc. Due to the quick change in the biomaterials
engineering, this course will also provide a review of up-to-date novel biomaterials research
and development. This course is for senior undergraduates from various disciplines of biological
science, chemical engineering, materials and biochemical engineering.
Prerequisites
Engineering Science 1021A/B.
Unless you have either the requisites for this course or written special permission from your
Dean to enroll in it, you may be removed from this course and it will be deleted from your
record. This decision may not be appealed. You will receive no adjustment to your fees in the
event that you are dropped from a course for failing to have the necessary prerequisites.
Corequisites
None
Antirequisites
None
Contact Hours
3 lecture hours, 1 tutorial hour, 0.5 course.
Instructor
Dr. J. Zhang (TEB 465) Telephone: 519-661-2111 ext: 88322; email: jzhan283@uwo.ca
Undergraduate Assistant
Marilyn Tudhope (TEB 477) Telephone: 519-661-2131 email: mtudhop@uwo.ca
CBE 4421A Course Outline
2
Teaching Assistants
Long-Yan Chen, email: lchen266@uwo.ca
Required Texts
Biomaterials: an introduction. Park, Joon, Lakes, R. S., Springer, NY. 2007.
Course Notes
Course notes will be available for download from the course website.
Laboratory Notes
None
Reference Text
Advanced Biomaterials: Fundamentals, Processing, and Applications. Ed. Bikramjit Basu,
Dhirendraa S. Katti, and Ashok Kumar, John Wiley & Sons, Inc., Hoboken, New Jersey. 2009.
Laboratory
None
Units
SI and other engineering units will be used.
General Learning Objectives
Knowledge Base
X
Individual Work
X
Problem Analysis
X
Team Work
X
Investigation
Design
Engineering Tools
X
X
X
Communication
Professionalism
Impact on Society
X
X
X
Ethics and Equity
Economics and
Project Management
Life-Long Learning
X
Specific Learning Objectives
1. To control the fundamental requirement of biomaterials and biocompatibility
2. To interpret the ability of biomaterials perform and the host response
3. To be familiar with the common types of materials and implant device currently utilized
in the surgical practice of medicine
4. To learn the manufacturing process of biomaterials, e.g. metals, ceramics, and polymers
5. To obtain the concepts of design biomaterials and devices.
6. To have the knowledge on how to achieve desired implant properties and performance
by using the principles of biomaterials engineering.
7. To know the regulation and ethical concerns for biomaterials and medical devices.
CBE 4421A Course Outline
Topics (topics and outline are subject to adjustments and changes)
1. Biomaterials and Biocompatibility
- Introduction to biomaterials
- Biocompatibility and Host response
- Experiment evaluation of biocompatibility
2. Structure and Properties of Artificial Biomaterials
- Bonding and crystal structure of metals and ceramics
- Bio-polymers and types of polymerization
- Composite materials
- Physical, chemical, and mechanical properties of biomaterials
3. Structure and Properties of Biological Materials
- Extracellular matrix
- Hard and soft tissues
- Interaction between cells and materials
4. Manufacture processing of biomaterials
-Metal processing
-Ceramic processing
-Polymer processing
-Surface treatment
5. Biomaterials Design and Characterization
- Metallic Implant Materials
- Ceramic Implant Materials
- Polymeric Implant Materials
- Composite Implant Materials
6. Application of Biomaterials:
- Artificial organs
- Dental implant
- Ophthalmologic applications
- Tissue Response to Implants
7. Commercialization of Implants
- Regulations and regulatory testing
- Ethics of biomaterials and implants
Evaluation
The final course mark will be determined as follows:
Assignments
30%
Quizzes and project
15%
3
CBE 4421A Course Outline
Final exam
4
55%
Final examination will be closed book. Only non-programmable pocket calculators will be
permitted.
Note
1) Students must pass the final examination to pass this course. Students who fail the final
examination will be assigned 48% if the aggregate mark is higher than 50%, or the aggregate
mark.
2) Assignments are to be handed into CBE 4421A locker (#462) located in TEB on the
specified due date provided by the Instructor.
Repeating All Components of the Course
In accordance with Senate and Faculty Policy, students who have failed an Engineering course
(i.e. <50%) must repeat all components of the course. No special permissions will be granted
enabling a student to retain laboratory, assignment or test marks from previous years.
Previously completed assignments and laboratories cannot be resubmitted for grading by the
student in subsequent years.
Use of English:
In accordance with Senate and Faculty Policy, students may be penalized up to 10% of the
marks on all assignments, tests, and examinations for the improper use of English. Additionally,
poorly written work with the exception of the final examination may be returned without
grading. If resubmission of the work is permitted, it may be graded with marks deducted for
poor English and/or late submission.
Attendance
Attendance in all lectures, tutorials and laboratories is mandatory. Any student, who, in the
opinion of the instructor, is absent too frequently from class or laboratory periods in any
course, will be reported to the Dean (after due warning has been given). On the
recommendation of the Department concerned, and with the permission of the Dean, the
student will be debarred from taking the regular examination in the course.
Cheating
University policy states that cheating is a scholastic offence. The commission of a scholastic
offence is attended by academic penalties, which might include expulsion from the program. If
you are caught cheating, there will be no second warning (see Scholastic Offence Policy in the
Western Academic Calendar).
Plagiarism
Students must write their essays and assignments in their own words. Whenever students take
an idea or a passage from another author, they must acknowledge their debt both by using
quotation marks where appropriate and by proper referencing such as footnotes or citations.
CBE 4421A Course Outline
5
Plagiarism is a major academic offence (see Scholastic Offence Policy in the Western Academic
Calendar).
The University of Western Ontario has software for plagiarism checking. Students may be
required to submit their work in electronic form for plagiarism checking.
Conduct:
Students are expected to arrive at lectures on time, and to conduct themselves during class in a
professional and respectful manner that is not disruptive to others.
Sickness and Other Problems:
Students should immediately consult with the instructor or Department Chair if they have any
problems that could affect their performance in the course. Where appropriate, the problems
should be documented. The student should seek advice from the Instructor or Department
Chair regarding how best to deal with the problem. Failure to notify the Instructor or
Department Chair immediately (or as soon as possible thereafter) will have a negative effect on
any appeal.
Please contact the course instructor if you require material in an alternate format or if any
other arrangements can make this course more accessible to you. You may also wish to contact
Services for Students with Disabilities (SSD) at 661-2111 x 82147 for any specific question
regarding an accommodation.
Notice
Students are responsible for regularly checking their Western email and notices posted on
Instructors' doors.
Consultation
Students are encouraged to discuss problems with their teaching assistant and/or instructors in
tutorial sessions. Office hours will be arranged for the students to see the instructors and
teaching assistants. Other individual consultation can be arranged by appointment with the
appropriate instructor.
Accreditation (AU) Breakdown
Engineering Design = 35%
Engineering Science = 65%
September 8, 2010 / af
The University Of Western Ontario
Faculty of Engineering
DEPARTMENT OF CHEMICAL AND BIOCHEMICAL ENGINEERING
CBE 4423A – Tissue Engineering
Course Outline 2010-2011
Description
Tissue Engineering integrates principles of engineering and life sciences towards the
fundamental understanding of structure-function relationships in normal and pathological
mammalian tissues. The course will cover the applications of engineering design concepts and
molecular cell biology in order to design biological substitutes to restore, maintain or improve
tissue and organ function.
Course Structure
This is a 4th year Chemical Engineering undergraduate course toggled with BME 9526, a
graduate-level course in Biomedical Engineering. Undergraduate and Graduate students attend
the same lecture, and write the same exam. However, graduate students will work an extra
individual project as part of the graduate course requirement.
Prerequisites
CBE 2290A/B or Biology 1222 or 1223, CBE 2221A/B, CBE 3322A/B, CBE 3324A/B.
Unless you have either the requisites for this course or written special permission from your
Dean to enroll in it, you will be removed from this course and it will be deleted from your
record. This decision may not be appealed. You will receive no adjustment to your fees in the
event that you are dropped from a course for failing to have the necessary prerequisites.
Corequisites
None
Antirequisites
None
Contact Hours
3 lecture hours, 1 tutorial hour, 0.5 course.
Instructor
Dr. K. Mequanint (TEB 439) Telephone: 519-661-2111 ext: 88573 email: kmequani@uwo.ca
Undergraduate Assistant
Marilyn Tudhope (TEB 477) Telephone: 519-661-2131 email: mtudhop@uwo.ca
CBE 4423A Course Outline
2
Teaching Assistants
Dawit Seifu, email: dseifu@uwo.ca
Required Text
None
Course Notes
Some skeletal lecture notes will be available for download from the course website.
Laboratory Notes
None
Reference Texts
Bernhard Palsson and Sangeeta Bhatia. Tissue Engineering, Pearson Prentice Hall, 2004.
Ronald Fournier. Basic Transport Phenomena in Biomedical Engineering. 2nd Edn. Taylor and
Francis. 2007.
Robert Lanza, Robert Langer, Joesph Vacanti. Principles of Tissue Engineering. 2nd ed., Academic
Press, 2000.
Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts and Peter Walter.
Molecular Biology of The Cell. Taylor and Francis. 4th Edition, 2002.
Laboratory
None
Units
SI and other engineering units will be used.
General Learning Objectives
Knowledge Base
Problem Analysis
Investigation
Design
Engineering Tools
Individual Work
X
Team Work
X
Communication
Professionalism
Impact on Society
Ethics and Equity
Economics and Project
Management
Life-Long Learning
X
X
Objectives
The modern chemical engineer needs a strong fundamental understanding of engineering
principles applied to life sciences. The application of engineering design principles, combined
with basic knowledge of molecular cell biology and materials science will be covered in this
course to provide students with a broad overview of the field of Tissue Engineering.
CBE 4423A Course Outline
3
The objectives of the course are to introduce:
• the application of engineering principles combined with basic knowledge of molecular
cell biology and materials science to provide the students with a broad overview of the
field of tissue engineering.
• the basics of tissue engineering, including cell-matrix interaction, cell migration and
growth, mechanical regulation, bioreactors, tissue preservation, and
immunomodulation/isolation. Due to the exponential growth this field has had over the
last decade it is impossible to cover detail aspects of tissue engineering but particular
applications of tissue engineering will be shown through selected examples from
literature.
• applications of mass transport to Tissue Engineering approaches.
• methods in analyzing and designing targeted engineered tissue products, evaluation of
tissue from a design perspective, scaffolding of cells using synthetic and natural
materials, genetic engineering techniques, and cell seeding and transplantation.
Engineered tissues for replacing vascular vessels, heart valves, cartilage, bone, skin etc.
will be presented and discussed throughout the course.
Topics
•
•
•
•
•
•
•
•
•
Introduction to Tissue Engineering
Fundamentals of Therapeutic Tissue Engineering
Cell Physiology and Function
The Extracellular Matrix
Cell adhesion, migration and the cytoskeleton role
Scaffolds for Tissue Engineering
Mass Transport and Bioreactors
Specific Applications of Tissue Engineered constructs
Emerging Technologies
Evaluation
The final course mark will be determined as follows:
Assignments
=
20%
Mid-term exam
=
25%
Final exam
=
55%
Both examinations will be closed book. Only non-programmable calculators will be permitted.
Note
1) Students must pass the final examination to pass this course. Students who fail the final
examination will be assigned 48% if the aggregate mark is more than 50% or the aggregate
mark.
2) Assignments are to be handed in to the CBE 4423A locker (#456) in TEB on the specified
due date provided by the instructor.
CBE 4423A Course Outline
4
Repeating All Components of the Course
In accordance with Senate and Faculty Policy, students who have failed an Engineering course
(i.e. <50%) must repeat all components of the course. No special permissions will be granted
enabling a student to retain laboratory, assignment or test marks from previous years.
Previously completed assignments and laboratories cannot be resubmitted for grading by the
student in subsequent years.
Use of English
In accordance with Senate and Faculty Policy, students may be penalized up to 10% of the
marks on all assignments, tests, and examinations for the improper use of English. Additionally,
poorly written work with the exception of the final examination may be returned without
grading. If resubmission of the work is permitted, it may be graded with marks deducted for
poor English and/or late submission.
Attendance
Attendance in all lectures, tutorials and labs is mandatory. Any student who, in the opinion of
the instructor, is absent too frequently from class or laboratory periods in any course, will be
reported to the Dean (after due warning has been given). On the recommendation of the
Department concerned, and with the permission of the Dean, the student will be debarred
from taking the regular examination in the course.
Cheating
University policy states that cheating is a scholastic offence. The commission of a scholastic
offence is attended by academic penalties, which might include expulsion from the program. If
you are caught cheating, there will be no second warning (see Scholastic Offence Policy in the
Western Academic Calendar).
Plagiarism
Students must write their essays and assignments in their own words. Whenever students take
an idea or a passage from another author, they must acknowledge their debt both by using
quotation marks where appropriate and by proper referencing such as footnotes or citations.
Plagiarism is a major academic offence (see Scholastic Offence Policy in the Western Academic
Calendar).
The University of Western Ontario has software for plagiarism checking. Students may be
required to submit their work in electronic form for plagiarism checking.
Conduct
Students are expected to arrive at lectures on time, and to conduct themselves during class in a
professional and respectful manner that is not disruptive to others.
CBE 4423A Course Outline
5
Sickness and Other Problems
Students should immediately consult with the instructor or Department Chair if they have any
problems that could affect their performance in the course. Where appropriate, the problems
should be documented. The student should seek advice from the Instructor or Department
Chair regarding how best to deal with the problem. Failure to notify the Instructor or
Department Chair immediately (or as soon as possible thereafter) will have a negative effect on
any appeal.
Please contact the course instructor if you require material in an alternate format or if any
other arrangements can make this course more accessible to you. You may also wish to contact
Services for Students with Disabilities (SSD) at 661-2111 x 82147 for any specific question
regarding an accommodation.
Notice
Students are responsible for regularly checking their Western email and notices posted on
Instructors' doors.
Consultation
Students are encouraged to discuss problems with their teaching assistant and/or instructor by
appointment. Office hours will be arranged for the students to see the instructor and teaching
assistants. Other individual consultation can be arranged by appointment with the appropriate
instructor.
Accreditation (AU) Breakdown
Science
=
45%
Engineering Science =
35%
Engineering Design =
20%
September 8, 2010 / af
The University Of Western Ontario
Faculty of Engineering
DEPARTMENT OF CHEMICAL AND BIOCHEMICAL ENGINEERING
CBE 4493A – POLYMER ENGINEERING
Course Outline 2010-2011
Description
The basics of polymer science and engineering are covered. The theory of macromolecules,
macromolecular chemistry and fundamentals of polymerization are discussed. Specific
manufacturing processes and polymer types are considered.
Prerequisites
CBE 2206A/B and CBE 2207A/B or the former 2216 or Chemistry 2213A/B and Chemistry 2223B
or GPE 2213A/B and GPE 2214A/B.
Unless you have either the prerequisites for this course or written special permission from your
Dean to enroll in it, you will be removed from this course and it will be deleted from your
record. This decision may not be appealed. You will receive no adjustment to your fees in the
event that you are dropped from a course for failing to have the necessary prerequisites.
Corequisites
None
Antirequisite
Chemistry 3320A/B.
Contact Hours
3 lecture hours, 1 tutorial hour, 0.5 course.
Instructor
Dr. W. Wan (TEB 433) Telephone: 519-661-2111 ext: 88440 email: wkwan@uwo.ca
Undergraduate Assistant
Marilyn Tudhope (TEB 477) Telephone: 519-661-2131 email: mtudhop@uwo.ca
Teaching Assistant
Darcy Small, email: dsmall3@uwo.ca
Required Text
Polymer Science and Technology, J.R. Fried, 2nd edition, Prentice Hall, 2003.
CBE 4493A Course Outline
2
Course Notes
None
Laboratory Notes
Lab notes will be provided by the faculty member.
Reference Texts
Encyclopedia of Polymer Science and Engineering, Wiley-Interscience, 1988.
Units
SI and other engineering units will be used.
General Learning Objectives
Knowledge Base
x
Individual Work
Problem Analysis
x
Team Work
Investigation
Design
Engineering Tools
x
x
x
Communication
Professionalism
Impact on Society
x
x
Ethics and Equity
Economics and Project
Management
Life-Long Learning
x
x
x
Specific Learning Objectives
At the end of this course students should:
• Have a sound understanding of the structures of several polymers and where polymers
are used in our everyday life.
• Understand natural, synthetic and ‘green’ polymers and their impact on environmental
sustainability.
• Understand the average distribution of molecular weights of polymers, (M n , M w and
M z ) the polydispersity index, and how to measure molecular weights and molecular
weight distributions by different methods.
• Be able to understand the kinetics of step-growth and chain-growth polymerizations
and copolymerizations, Mayo-Lewis equation, free-radical polymerizations (e.g.
emulsion, suspension and solution, polymerization), and catalysis (e.g. Ziegler-Natta and
metallocene polymerization).
• Understand the effect of chemical structure on polymer properties, crosslinking,
polymer crystallinity, molecular weight, the glass transition temperature, tacticity,
nonlinear polymers, composites, and natural polymers.
• Understand the mechanical and visco-elastic properties of polymers.
• Understand flow behaviour of polymeric fluids (viscometric flow and the theories of
shear-viscosity).
• Understand the thermal, acoustic, permeability, optical, and electrical properties of
polymers.
CBE 4493A Course Outline
•
•
3
Have a sound knowledge of the principals of polymer processing, including extrusion,
injection molding, blow molding and fiber spinning.
Understand the engineering applications of polymers.
Evaluation
The final course mark will be determined as follows:
Assignments
20%
Midterm Examination
30%
Final Examination
50%
Please note that both examinations will be closed book.
Note
(1) Students must pass each examination to pass this course. Students who failed either of
the exams will be assigned 48% if the aggregate mark is more than 50%, or the aggregate mark.
(2) Assignments are to be handed in the CBE 4493A locker (#456) in TEB on the specified due
date provided by the Instructor.
Repeating All Components of the Course
In accordance with Senate and Faculty Policy, students who have failed an Engineering course
(i.e. <50%) must repeat all components of the course. No special permissions will be granted
enabling a student to retain laboratory, assignment or test marks from previous years.
Previously completed assignments and laboratories cannot be resubmitted for grading by the
student in subsequent years.
Use of English
In accordance with Senate and Faculty Policy, students may be penalized up to 10% of the
marks on all assignments, tests, and examinations for the improper use of English. Additionally,
poorly written work with the exception of the final examination may be returned without
grading. If resubmission of the work is permitted, it may be graded with marks deducted for
poor English and/or late submission.
Attendance
Attendance in all lectures, tutorials and laboratories is mandatory. Any student who, in the
opinion of the instructor, is absent too frequently from class or laboratory periods in any
course, will be reported to the Dean (after due warning has been given). On the
recommendation of the Department concerned, and with the permission of the Dean, the
student will be debarred from taking the regular examination in the course.
Cheating
University policy states that cheating is a scholastic offence. The commission of a scholastic
offence is attended by academic penalties, which might include expulsion from the program. If
you are caught cheating, there will be no second warning (see Scholastic Offence Policy in the
Western Academic Calendar).
CBE 4493A Course Outline
4
Plagiarism
Students must write their essays and assignments in their own words. Whenever students take
an idea or a passage from another author, they must acknowledge their debt both by using
quotation marks where appropriate and by proper referencing such as footnotes or citations.
Plagiarism is a major academic offence (see Scholastic Offence Policy in the Western Academic
Calendar).
The University of Western Ontario has software for plagiarism checking. Students may be
required to submit their work in electronic form for plagiarism checking.
Conduct
Students are expected to arrive at lectures on time, and to conduct themselves during class in a
professional and respectful manner that is not disruptive to others.
Sickness and Other Problems
Students should immediately consult with the instructor or Department Chair if they have any
problems that could affect their performance in the course. Where appropriate, the problems
should be documented. The student should seek advice from the Instructor or Department
Chair regarding how best to deal with the problem. Failure to notify the Instructor or
Department Chair immediately (or as soon as possible thereafter) will have a negative effect on
any appeal.
Please contact the course instructor if you require material in an alternate format or if any
other arrangements can make this course more accessible to you. You may also wish to contact
Services for Students with Disabilities (SSD) at 661-2111 x 82147 for any specific question
regarding an accommodation.
Notices
Students are responsible for regularly checking their Western email and notices posted on
Instructors' doors.
Consultation
Students are encouraged to discuss problems with their teaching assistant and/or instructor in
tutorial sessions. Office hours will be arranged for the students to see the instructor and
teaching assistants. Other individual consultation can be arranged by appointment with the
appropriate instructor.
Accreditation (AU) Breakdown
Engineering Science = 70 %
Engineering Design = 30 %
September 14, 2010 / af
The University of Western Ontario
Faculty of Engineering
DEPARTMENT OF CHEMICAL AND BIOCHEMICAL ENGINEERING
CBE 4497 - Chemical Process and Plant Design
Course Outline 2010-2011
Description
A design is prepared for a full-scale chemical process. It involves sizing of major pieces of
equipment, an estimate of the requirements for materials and energy, and calculation of
different costs. The course requires integration of knowledge and skills learned and derived
from other courses in the curriculum. Problem formulation, alternative design solutions and
professional decision making are emphasized.
Objectives
Based on case study format, this course introduces students to chemical process synthesis and
analysis and equipment sizing through creative problem solving and teamwork while applying
basic principles in chemical engineering and economics learned in other courses in the
curriculum. The general objectives are for the student to become able to:
•
•
•
•
•
apply engineering and professional judgement to propose solutions to open-ended design
problems;
formulate problems and apply decision making to evaluate design alternatives;
identify safety, environmental, social, legal and economic issues, and their impact on design
decisions;
develop strong technical communication skills in order to present and defend technical
information and design decisions in both written and oral format; and
recognize the need for continual (life-long) learning to keep abreast of new developments
and information that could affect decisions related to design, modifications and
improvements in chemical processes.
These objectives are accomplished within the framework of a workshop, simulating to the
extent possible, and the real world industrial environment. During the workshops, groups of up
to six students are given guidance and coaching (interactive learning) to assist in moving
forward the design project. Each group of project engineers is assigned to a specific section
head (Teaching Assistant).
Prerequisites
CBE 3325A/B, CBE 3317A/B or the former CBE 3397, CBE 3323A/B, CBE 2220A/B, CBE 2224A/B,
CBE 3315A/B, CBE 3322A/B.
CBE 4497 Course Outline
2
Unless you have either the requisites for this course or written special permission from your
Dean to enroll in it, you may be removed from this course and it will be deleted from your
record. This decision may not be appealed. You will receive no adjustment to your fees in the
event that you are dropped from a course for failing to have the necessary prerequisites.
Corequisites
Business Administration 2299 or registration in Option C of the Chemical Engineering program.
Antirequisites
CEE 4441, ECE 4416, MME 4419, MME 4499, SE 4450, ES 4499.
Contact Hours
1 lecture hour, 6 tutorial hours, 1.0 course.
Instructors
Dr. A. Prakash (TEB 441) Telephone: 519-661-2111 ext: 88528 email: aprakas2@uwo.ca
Dr. S. Barghi (TEB 447) Telephone: 519-661-2111 ext: 81275 email: sbarghi2@uwo.ca
Dr. A. Margaritis (TEB 377) Telephone: 519-66-2111 ext: 82146 email: amarg@uwo.ca
Undergraduate Assistant
Marilyn Tudhope (TEB 477) Telephone: 519-661-2131 email: mtudhop@uwo.ca
Teaching Assistants
Anil Jhawar, email: ajhawar@uwo.ca
Matthew Klaas, email: mklaas@uwo.ca
Maryam Mogagheghi, email: mmohagh2@uwo.ca
Flora Parveen email: fparveen@uwo.ca
Hammayon Pervez, email: hpervez2@uwo.ca
Kai Pisters, email: kpisters@uwo.ca
Recommended Text
G. Towler and R. Sinnott “Chemical Engineering Design”, Elsevier, Inc. 2008.
Course Notes
Course notes will be available for download from the course website.
Reference Texts
Jones, D.S.J., “Elements of Chemical Process Engineering”, John Wiley and Sons, 1996.
Ludwigm E.E., “Applied Process Design for Chemical and Petrochemical Plants”, Vol. 1-3, 2nd and
3rd edition, Gulf Publishing Co., 1983, 1995.
Perry, R.H. and D.W. Green, “Perry’s Chemical Engineers Handbook”, 7th edition, McGraw-Hill
Inc., 1997.
Sinnot, R.K., “Coulson and Richardson’s Chemical Engineering”, Vol. 6, 3rd edition ButterworthHeinemann, 1992.
CBE 4497 Course Outline
3
Soares, C., “Process Engineering Equipment Handbook”, McGraw Hill, New York, 2002.
Turton R., R.C. Bailie, W.B. Whiting, J.A. Shaeiwitz,”Analysis, Synthesis and Design of Chemical
Processes”, 2nd edition, Prentice hall PTR, 2003.
Ulrich, G.D., “A Guide to Chemical Engineering Process Design and Economics”, John Wiley &
Sons, New York, 1984.
Walas, S.M., “Chemical Process Equipment Selection and Design”, Butterworth-Heinemann,
1990.
Reference to other books and articles will be made at the appropriate time during the course
Laboratory
None
Units
SI units will be used in lectures and examinations.
General Learning Objectives
Knowledge Base
X
Individual Work
X
Problem Analysis
X
Team Work
X
Investigation
Design
Engineering Tools
X
X
X
Communication
Professionalism
Impact on Society
X
X
X
Ethics and Equity
Economics and
Project Management
Life-Long Learning
X
X
X
Specific Learning Objectives
The course is organized to develop following professional and job related skills of students
while they apply acquired knowledge of engineering concepts and principles to an independent
study industrial design project.
Team Work and Time Management
Students should be able to:
• work in team as they become more familiar with dynamics of team work and learn to make
use of strengths of team members
• divide a project into tasks and sub-tasks with deadlines and milestones to allow scheduling
and resource allocation and utilization
Information Collection, Analysis and Synthesis
Students should be able to:
• collect required information from different sources including literature, industry,
equipment suppliers, internet, specialists etc.
• analyse sometimes conflicting information and learn to deal with it
CBE 4497 Course Outline
4
Critical Thinking (applied to design process)
Students should be able to:
• recognize existence of alternative solutions for the same problem.
• compare alternatives based on selected criteria
• ensure check calculations and consultations before making a recommendation
Engineering Judgment
Students should be able to:
• apply approximations in design calculations based on sound reasoning and documentation
•
apply practical considerations to reduce downtime, improve safety and operability of a
system being designed
Communication
Students should be able to:
• present their work both orally and in written format as per acceptable standards
Progress will depend on a number of factors including complexity of the selected process,
availability of process information, industrial contacts established by group, etc. Initiative and
creativity is required from every student. This course draws on knowledge, skills and
techniques learned in prerequisite and corequisite courses to solve practical engineering
problems. It is a finishing course: students need to demonstrate sound design and
professional capabilities before they can graduate.
Evaluation
The final course mark will be determined as follows:
Project Stake Out
5%
Participation in Design Workshops
6%
Detailed Flow Plan with Description (grp. mark)
8%
Short-cut Equipment Design
10%
First Oral Presentation (50% ind. mark, 50% grp.)
9%
Final Oral Presentation (60% ind. mark, 40% grp.) 12%
First Design Report (50% ind. mark, 50% grp.)
20%
Final Design Report (60% ind. mark, 40% grp.)
30%
Note
Students must secure a passing mark (>50%) in both the final oral presentation and final design
report to pass this course.
1. Design Reports
A design report is due from each group at the end of each term culminating the efforts of
the group. The reports will be submitted to the Undergraduate Assistant in TEB 477.
Format for design report is given in course guide book.
CBE 4497 Course Outline
First Formal Report due:
Final Formal Report due:
5
December 6, 2010
April 4, 2011
2. Oral Presentations
Two oral presentations will be made by each design group, one in each term. Each student
will take part in the presentations. Presentation schedule will be distributed in class about
two weeks before presentation week.
First Formal Oral Presentation
Final Formal Oral Presentation
November 15-19, 2010
March 23, 2011
3. Detailed Flow Plan with Description
Each design team will hand in a detailed flow plan of the process drawn on a 60cmX90cm
sheet together with a description of the process to its section Teaching Assistant by the due
date (to be determined).
Repeating All Components of the Course
In accordance with Senate and Faculty Policy, students who have failed an Engineering course
(i.e. <50%) must repeat all components of the course. No special permissions will be granted
enabling a student to retain laboratory, assignment or test marks from previous years.
Previously completed assignments and laboratories cannot be resubmitted for grading by the
student in subsequent years.
Use of English
In accordance with Senate and Faculty Policy, students may be penalised up to 10% of the
marks on all assignments, tests, and examinations for the improper use of English. Additionally,
poorly written work with the exception of the final examination may be returned without
grading. If resubmission of the work is permitted, it may be graded with marks deducted for
poor English and/or late submission.
Cheating
University policy states that cheating is a scholastic offence. The commission of a scholastic
offence is attended by academic penalties, which might include expulsion from the program. If
you are caught cheating, there will be no second warning (see Scholastic Offence Policy in the
Western Academic Calendar).
Plagiarism
Students must write their essays and assignments in their own words. Whenever students take
an idea or a passage from another author, they must acknowledge their debt both by using
quotation marks where appropriate and by proper referencing such as footnotes or citations.
Plagiarism is a major academic offence (see Scholastic Offence Policy in the Western Academic
Calendar).
CBE 4497 Course Outline
6
The University of Western Ontario has software for plagiarism checking. Students may be
required to submit their work in electronic form for plagiarism checking.
Attendance
Attendance at all lectures, tutorials and laboratories is mandatory. Any student who, in the
opinion of the instructor, is absent too frequently from class, or workshop/tutorial periods will
be reported to the Dean (after due warning has been given). On the recommendation of the
Department concerned, and with the permission of the Dean, the student will be debarred
from making final oral presentation and submission of final design report.
Conduct
Students are expected to arrive at lectures on time, and to conduct themselves during class in a
professional and respectful manner that is not disruptive to others.
Sickness and Other Problems
Students should immediately consult with the instructor or Department Chair if they have any
problems that could affect their performance in the course. Where appropriate, the problems
should be documented. The student should seek advice from the Instructor or Department
Chair regarding how best to deal with the problem. Failure to notify the Instructor or
Department Chair immediately (or as soon as possible thereafter) will have a negative effect on
any appeal.
Please contact the course instructor if you require material in an alternate format or if any
other arrangements can make this course more accessible to you. You may also wish to contact
Services for Students with Disabilities (SSD) at 661-2111 x 82147 for any specific question
regarding an accommodation.
Notice
Students are responsible for regularly checking their Western email and notices posted in front
of chief instructor’s offices.
Consultation
Students are encouraged to discuss problems with their teaching assistant and/or instructor in
tutorial sessions. Office hours will be arranged for the students to see the instructor and
teaching assistants. Other individual consultation can be arranged by appointment with the
appropriate instructor.
Accreditation (AU) Breakdown
Complimentary Studies
=
Engineering Design
=
September 14, 2010 / af
25%
75%
The University of Western Ontario
Faculty of Engineering
DEPARTMENT OF CHEMICAL AND BIOCHEMICAL ENGINEERING
CBE 4499 - Chemical Engineering Design for Medical Students
Course Outline 2010-2011
Description
Selected chemical, biochemical or pharmaceutical processes or processes for pollution
abatement will be designed. Alternatively, the design of specific biomedical devices may be
carried out. Chemical engineering principles will be employed. The design will include problem
formulation, detailed design of equipment, environmental, economic and legal issues, and
safety consideration.
Objectives
The student will learn to apply basic principles in chemical and biochemical engineering and
economics learned in other courses in the curriculum towards the design of a medically
relevant process or device. The general objectives are for the student to become able to:
•
•
•
•
•
apply engineering and professional judgement to propose solution to open-ended design
problems;
formulate problems and apply decision making to evaluate design alternatives,
demonstrate initiative in applying innovative solutions;
identify safety, environmental, social, legal, ethical and economic issues, and their impact
on design decisions;
develop strong technical communication skills in order to present and defend technical
information and design decisions in both written and oral format; and
recognize the need for continual (life-long) learning to keep abreast of new developments
and information that could affect decisions related to design, modifications and
improvements.
These objectives are accomplished within the framework of a workshop, simulating to the
extent possible, and the real world industrial environment. Each design project is conducted
either individually or in small groups of up to three students. A coach (supervisor) will be
identified for each project. During the workshops, students are given guidance and coaching
(interactive learning) to assist in moving the design project forward.
Prerequisites
Completion of third year of the Chemical Engineering program, Option E, and acceptance in
concurrent degree program with Medicine.
CBE 4499 Course Outline
2
Unless you have either the requisites for this course or written special permission from your
Dean to enroll in it, you may be removed from this course and it will be deleted from your
record. This decision may not be appealed. You will receive no adjustment to your fees in the
event that you are dropped from a course for failing to have the necessary prerequisites.
Corequisites
None
Antirequisites
None
Contact Hours
6 laboratory hours
Coordinator
Dr. A. Prakash (TEB 441) Telephone: 519-661-2111 ext. 88528 email: aprakas2@uwo.ca
Required Textbook
None
Course Notes
None
Reference Texts
Fung, Y.C., (Ed.) “Introduction to Bioengineering”, World Scientific, 2001.
Jones, D.S.J., “Elements of Chemical Process Engineering”, John Wiley and Sons, 1996.
Perry, R.H. and D. W. Green "Perry’s Chemical Engineers Handbook", 7th edition, McGraw-Hill
Inc., 1997.
Seider, W.D., J.D. Seader, and D.R. Lewin, “Product and Process Design Principles”, John Wiley &
Sons Inc. 1999.
Sinnot, R.K., “Coulson and Richardson’s Chemical Engineering", 3rd edition ButterworthHeinemann, 1993.
Ulrich, G.D., “A Guide to Chemical Engineering Process Design and Economics”, John Wiley &
Sons, New York, 1984.
Reference to other books and articles will be made available at the appropriate time during the
course.
Laboratory
None
Units
SI units will be used in lectures and examinations.
CBE 4499 Course Outline
3
General Learning Objectives
Knowledge Base
Individual Work
X
Problem Analysis
X
Team Work
X
Investigation
Design
Engineering Tools
X
X
X
Communication
Professionalism
Impact on Society
X
X
X
Ethics and Equity
Economics and Project
Management
Life-Long Learning
X
X
Specific Learning Objectives
The course is organized to develop professional and job related skills of students by applying
the acquired knowledge of engineering concepts and principles to an independent study
industrial process or device. Progress will depend on a number of factors including complexity
of the selected process, availability of process information, industrial contacts established by
group, etc. Initiative and creativity is required from every student. This course draws on
knowledge, skills and techniques learned in prerequisite courses to solve practical
engineering problems. Students need to demonstrate sound design and professional
capabilities.
Information Gathering, Analysis and Synthesis
Students should be able to:
• collect required information from different sources including literature, industry,
equipment suppliers, internet, specialists etc.
• analyse sometimes conflicting information and learn to deal with it
• synthesize information to meet desired objectives
Critical Thinking
Students should be able to:
• recognize existence of alternative solutions for the same problem
• compare alternatives based on selected criteria for a given problem
• ensure check calculations and consultations before making a recommendation
Engineering Judgment
Students should be able to:
• apply approximations in design calculations based on sound reasoning and documentation
• apply practical considerations to reduce downtime, improve safety and operability in a cost
effective and environmentally friendly manner
Communication
Students should be able to:
• present and defend their work both orally and in written format as per acceptable
standards
CBE 4499 Course Outline
4
Team Work and Time and Resource Management (where applicable)
Students should be able to:
• work in team as they become more familiar with dynamics of team work and learn to make
use of strengths of each team member
• divide a project into tasks and sub-tasks with deadlines and milestones to allow scheduling
and resource allocation and utilization
Evaluation
Progress Report
Final Design Report
Oral presentation
30%
50%
20%
Note: Students must secure pass mark (50%) in both oral presentation and final design report
to pass this course.
1. Progress Report
It will include: Abstract♦Introduction♦Need analysis based on demand♦Available
options♦Configuration of proposed design♦Test plans (if applicable)♦Preliminary design
calculations♦Conclusions and Recommendations♦References♦Appendix. The report will
be submitted to the advisor.
2. Final Design Report
Updates: Abstract, Introduction, Need analysis and Available options, Conclusions and
Recommendations, References and Appendix from first term report
Include: Results of testing ♦ Detailed design calculations ♦ Final design configuration with
2-D and 3-D drawings ♦Safety considerations♦Costing and Economic analysis
3. Oral Presentations (date to be determined)
Each student will make an oral presentation before submission of final report in the second
term.
Use of English
In accordance with Senate and Faculty Policy, students may be penalised up to 10% of the
marks on all assignments, tests, and examinations for the improper use of English. Additionally,
poorly written work with the exception of the final examination may be returned without
grading. If resubmission of the work is permitted, it may be graded with marks deducted for
poor English and/or late submission.
Cheating
University policy states that cheating, including plagiarism is a scholastic offence. The
commission of a scholastic offence is attended by academic penalties that might include
expulsion from the program. If you are caught cheating, there will be no second warning.
CBE 4499 Course Outline
5
Attendance
Any student who, in the opinion of the instructor, is absent too frequently from class, or
workshop/tutorial periods will be reported to the Dean (after due warning has been given). On
the recommendation of the Department concerned, and with the permission of the Dean, the
student will be debarred from making final oral presentation and submission of final design
report.
Conduct
Students are expected to arrive at lectures on time, and to conduct themselves during class in a
professional and respectful manner that is not disruptive to others.
Sickness and Other Problems
Students should immediately consult with the instructor or Department Chair if they have any
problems that could affect their performance in the course. Where appropriate, the problems
should be documented. The student should seek advice from the Instructor or Department
Chair regarding how best to deal with the problem. Failure to notify the Instructor or
Department Chair immediately (or as soon as possible thereafter) will have a negative effect on
any appeal.
Please contact the course instructor if you require material in an alternate format or if any
other arrangements can make this course more accessible to you. You may also wish to contact
Services for Students with Disabilities (SSD) at 661-2111 x 82147 for any specific question
regarding an accommodation.
Notice
Students are responsible for regularly checking their Western email and notices posted in front
of chief instructor’s office.
Consultation
Students are encouraged to discuss problems with their teaching assistant and/or instructor in
tutorial sessions. Office hours will be arranged for the students to see the instructor and
teaching assistants. Other individual consultation can be arranged by appointment with the
appropriate instructor.
Accreditation (AU) Breakdown
Complimentary Studies
= 25%
Engineering Design
= 75%
September 8, 2010 / af
The University of Western Ontario
Faculty of Engineering
DEPARTMENT OF CHEMICAL AND BIOCHEMICAL ENGINEERING
GPE 4484A – Green Fuels and Chemicals
Course Outline 2010-2011
Description
This course describes what are green fuels and chemicals and the main current or potential
processes used to produce green fuels and chemicals. The general objectives are for the
student to:
•
•
•
•
•
Be aware of the issues associated with the production of fuels and chemicals from fossil
resources
Develop a good knowledge of the current processes that are used on a commercial scale to
produce green fuels and chemicals, their advantages and drawbacks
Be introduced to the possible future processes to produce green fuels and chemicals, their
advantages and drawbacks
Gain knowledge to integrate various processes in a bio-refinery
Be aware of the socio-economic and environmental impacts of the various processes
Prerequisites
CBE 2207A/B or GPE 2214A/B; CBE 2224A/B or GPE 2218A/B; CBE 3315A/B or GPE 3315A/B.
Unless you have either the requisites for this course or written special permission from your
Dean to enroll in it, you will be removed from this course and it will be deleted from your
record. This decision may not be appealed. You will receive no adjustment to your fees in the
event that you are dropped from a course for failing to have the necessary prerequisites.
Corequisites
None
Antirequisites
CBE 4467A/B.
Contact Hours
3 lecture hours, 1 tutorial hour, 0.5 course.
Instructors
Dr. F. Berruti (CMLP 2331) Telephone: 519-661-2111 ext: 88771 email: fberruti@uwo.ca
Dr. C. Briens (CMLP 2333) Telephone: 519-661-2111 ext: 88865 email: cbriens@uwo.ca
GPE 4484A Course Outline
2
Undergraduate Assistant
Marilyn Tudhope (TEB 477) Telephone: 519-661-2131 email: mtudhop@uwo.ca
Teaching Assistant
Feng Li, email: fli47@uwo.ca
Required Text
None
Course Notes
Course notes will be available on WebCT.
Reference Text
None
Units
SI units will be used in lectures and examinations.
General Learning Objectives
Knowledge Base
x
Individual Work
Problem Analysis
x
Team Work
Investigation
Design
Engineering Tools
x
x
x
Communication
Professionalism
Impact on Society
x
Ethics and Equity
Economics and Project
Management
Life-Long Learning
x
x
x
x
Specific Learning Objectives
Introduction: Why we need Green Fuels and Chemicals. Biomass resources (Cedric Briens)
At the end of this topic, students should:
• be aware of the environmental and political drivers behind the development of green fuels
and chemicals
• have a general knowledge of the processes used for the production of fuels and chemicals
from fossil resources
• be aware of the environmental problems associated with these processes
Biomass/BioFuels Combustion (Cedric Briens)
At the end of this topic, students should:
• know the processes used for the combustion of wood and residues from agricultural, food
processing and municipal waste operations, as well as the processes for the combustion of
fuels derived from these feedstocks
GPE 4484A Course Outline
•
be aware of the environmental and logistic problems associated with these processes
Biomass Gasification (Cedric Briens)
At the end of this topic, students should:
• know the processes used for the gasification of wood and residues from agricultural, food
processing and municipal waste operations
• be aware of the environmental and logistic problems associated with these processes
Pyrolysis to biochar, bio-oil and biogas (Cedric Briens)
At the end of this topic, students should:
• understand the processes that are used to pyrolyze biomass
• be aware of the technical and environmental problems associated with the use of raw biooils and biochar
Processing and refining of bio-oils and biochar (Cedric Briens)
At the end of this topic, students should:
• understand how bio-oil can be stabilized and cleaned
• know how bio-oil can be upgraded to a transportation fuel
• understand the various applications for bio-char
• know how to transform bio-char in higher value products
Biodiesel (Cedric Briens)
At the end of this topic, students should:
• know the processes that are used to produce biodiesel, including biochemical and
thermochemical methods
• understand the social, economical and political problems associated with the various
production schemes
Bioethanol and biobutanol (Franco Berruti)
At the end of this topic, students should:
• know the processes that are used to produce bioethanol, including biochemical and
thermochemical methods
• know the processes that are used to produce biobutanol, including biochemical and
thermochemical methods
• understand the social, economical and political problems associated with the various
production schemes
Biogas by fermentation (Franco Berruti)
At the end of this topic, students should:
• know the various fermentation processes that can be used to transform agricultural,
industrial and municipal waste into biogas
• understand the various issues associated with the purification and use of biogas
3
GPE 4484A Course Outline
4
Syngas and hydrogen production. Syngas conversion to clean fuels and chemicals (Franco
Berruti)
At the end of this topic, students should:
• understand the processes that are used to generate syngas
• know the processes that are used for hydrogen production from syngas
• know the processes that are used to convert syngas to fuels
• know the main processes that are used to convert syngas to chemicals
Product Separation and Purification (Franco Berruti)
At the end of this topic, students should:
• understand the processes that are used to extract and purify products, with a stress on
green processes
Extraction and Purification of Green Chemicals from Renewable Resources (Franco Berruti)
At the end of this topic, students should:
• know the major green chemicals that are obtained from renewable resources
• understand the processes that are used to produce chemicals from renewable resources
Economics and Social Impact. Government Policies (Franco Berruti)
At the end of this topic, students should:
• know how to evaluate the economics and social impact of green fuels and chemicals
• be aware of the major, relevant government policies
Evaluation
The final course mark will be determined as follows:
Assignments
30%
Final Exam
70%
Exam will be closed book. Programmable calculators not allowed. Students will be provided
with a list of potential questions from which the exam questions will be selected. Questions
will refer both to the course lectures and the assignments.
Notes
1) Students must pass the final examination to pass this course. Students who fail the final
examination will be assigned 48% if the aggregate mark is higher than 50%, or the aggregate
mark.
2) Assignments are to be handed into GPE 4484A locker (#458) located in TEB on the specified
due date provided by the Instructor.
GPE 4484A Course Outline
5
Repeating All Components of the Course
In accordance with Senate and Faculty Policy, students who have failed an Engineering course
(i.e. <50%) must repeat all components of the course. No special permissions will be granted
enabling a student to retain laboratory, assignment or test marks from previous years.
Previously completed assignments and laboratories cannot be resubmitted for grading by the
student in subsequent years.
Use of English
In accordance with Senate and Faculty Policy, students may be penalized up to 10% of the
marks on all assignments, tests, and examinations for the improper use of English. Additionally,
poorly written work with the exception of the final examination may be returned without
grading. If resubmission of the work is permitted, it may be graded with marks deducted for
poor English and/or late submission.
Attendance
Any student who, in the opinion of the instructor, is absent too frequently from class or
laboratory periods in any course, will be reported to the Dean (after due warning has been
given). On the recommendation of the Department concerned, and with the permission of the
Dean, the student will be debarred from taking the regular examination in the course.
Cheating
University policy states that cheating is a scholastic offence. The commission of a scholastic
offence is attended by academic penalties, which might include expulsion from the program. If
you are caught cheating, there will be no second warning (see Scholastic Offence Policy in the
Western Academic Calendar).
Plagiarism
Students must write their essays and assignments in their own words. Whenever students take
an idea or a passage from another author, they must acknowledge their debt both by using
quotation marks where appropriate and by proper referencing such as footnotes or citations.
Plagiarism is a major academic offence (see Scholastic Offence Policy in the Western Academic
Calendar).
The University of Western Ontario has software for plagiarism checking. Students may be
required to submit their work in electronic form for plagiarism checking.
Conduct
Students are expected to arrive at lectures on time, and to conduct themselves during class in a
professional and respectful manner that is not disruptive to others.
Sickness and Other Problems
Students should immediately consult with the instructor or Department Chair if they have any
problems that could affect their performance in the course. Where appropriate, the problems
should be documented. The student should seek advice from the Instructor or Department
GPE 4484A Course Outline
6
Chair regarding how best to deal with the problem. Failure to notify the Instructor or
Department Chair immediately (or as soon as possible thereafter) will have a negative effect on
any appeal.
Please contact the course instructor if you require material in an alternate format or if any
other arrangements can make this course more accessible to you. You may also wish to contact
Services for Students with Disabilities (SSD) at 661-2111 x 82147 for any specific question
regarding an accommodation
Notice
Students are responsible for regularly checking their Western email and notices posted on
Instructors' doors.
Consultation
Students are encouraged to discuss problems with their teaching assistant and/or instructor in
tutorial sessions. Office hours will be arranged for the students to see the instructor and
teaching assistants. Other individual consultation can be arranged by appointment with the
appropriate instructor.
Accreditation (AU) Breakdown
Engineering Science = 70%
Engineering Design = 30%
September 8, 2010 / af
The University of Western Ontario
Faculty of Engineering
DEPARTMENT OF CHEMICAL AND BIOCHEMICAL ENGINEERING
CBE 4403B - BIOCHEMICAL SEPARATION PROCESSES
COURSE OUTLINE 2010-2011
Description
The main objective of this course is to introduce the student to the basic fundamentals of
downstream separation and purification processes such as membrane separation processes,
protein separation and purification and other separation processes of economic importance to the
fermentation industry.
Prerequisites
CBE 2290A/B or Biology 1222 or Biology 1223.
Unless you have either the requisites for this course or written special permission from your Dean
to enroll in it, you may be removed from this course and it will be deleted from your record. This
decision may not be appealed. You will receive no adjustment to your fees in the event that you
are dropped from a course for failing to have the necessary prerequisites.
Corequisites
None.
Antirequisites
None.
Contact Hours
3 lecture hours, 1 tutorial hour, 0.5 course.
Instructor
Dr. W.K. Wan (TEB 433) Telephone: 519-661-2111 ext: 88440 email: wkwan@uwo.ca
Undergraduate Assistant
Marilyn Tudhope (TEB 477) Telephone: 519-661-2111 ext: 82131 email: mtudhop@uwo.ca
Required Text
J. Krijgsman, “Product Recovery in Bioprocess Technology”, Butterworth-Heinemann, 1992. Will be
available at the University Bookstore (©M# 4933).
Reference Text
M.L. Schuler, F. Kargi, “Bioprocess Engineering: Basic Concepts”, Prentice Hall, 1992.
CBE 4403B Course Outline
2
Course Notes
Course notes will be available for download from the course website.
Laboratory Notes
None.
Laboratory
None.
Units
SI units will be used.
General Learning Objectives
Knowledge Base
Individual Work
Problem Analysis
Team Work
Investigation
Design
Engineering Tools
Communication
Professionalism
Impact on Society
Ethics and Equity
Economics and Project
Management
Life-Long Learning
General Learning Objectives
This course deals with downstream separation and purification unit operations of a bioprocess,
and complements the other three Biochemical Engineering courses: CBE 2290a - Fundamentals of
Biochemcial and Environmental Engineering, CBE 3301a - Biochemical Reaction Engineering, and
CBE 3320b - Bioprocess Engineering. Completion of all four Biochemical Engineering courses will
provide information and background which will be useful in the design of a typical bioprocess.
In many commercial bioprocesses, separation and purification of the final product represent the
major component of the total production cost. The objectives of this course are to enable the
student to identify appropriate combinations of separation and purification technologies for
various types of bioproducts and to apply fundamental principels to the design of these unit
operations.
Specific Learning Objectives:
Introduction
At the end of this topic, students should be able to:
• Distinguish bioproduct market sectors.
• Describe general stages in bioproduct recovery processes.
• Calculate yield, and purification and separation factors.
• Select prospective unit operations based on bioproduct size and recovery stage.
• Ask critical questions relevant to recovery process design.
CBE 4403B Course Outline
3
Release of Intracellular Components
At the end of this topic, students should be able to:
• Compare morphology and cell wall structure of cell types representative of fermentation
broths.
• Describe operations used to prepare cells for disruption.
• Identify various non-mechanical methods of cell disruption.
• Describe the principles of operation for bead mills and high-pressure homogenizers.
• Describe how various factors influence performance of bead mills and homogenizers.
• Calculate parameters describing bioproduct release kinetics.
• Quantitatively analyze various processing modes (multi-pass, batch recycle and continuous
recycle) for cell disruption.
Solid-liquid Separation
At the end of this topic, students should be able to:
• Describe common broth pre-treatment methods employed prior to solid-liquid separation.
• Determine specific cake resistance and medium resistance for constant-pressure filtration.
• Calculate parameters describing compressible filter cakes, given V vs. t data.
• Describe the principles of operation of common types of process filters.
• Calculate required filter area for given processing rate using rotary vacuum filtration.
• Calculate centrifugal acceleration, G-factor and drift velocity.
• Describe the principles of operation of common types of process centrifuges.
• Use sigma concept to scale up tubular and disc-stack centrifuges.
• Describe laboratory and pilot scale testing methods for centrifugal separations.
Concentration of Bioproducts - I (Membrane Separation)
At the end of this topic, students should be able to:
• Distinguish micro-, ultra- and hyper-filtration according to particle size and pressure
difference.
• Compare and contrast cross-flow vs. dead-end filtration.
• Describe the principles of operation of common types of cross-flow filtration modules.
• Define rejection co-efficient, concentration factor, permeate yield and non-permeate yield for
batch and continuous modes of operation.
• Calculate mass-transfer coefficient and permeate flux from both experimental data and
dimensionless correlations.
• Determine final concentration and required membrane area for various operating modes
(batch recycle, and single and multi-stage feed-and-bleed).
• Quantitatively describe continuous- and discrete-batch diafiltration processes.
CBE 4403B Course Outline
4
Concentration of Bioproducts - II
At the end of this topic, students should be able to:
• Describe the principles of operation of aqueous two-phase extraction.
• Describe how the electric double layer surrounding a protein molecule influences
precipitation.
•
Describe the principles of operation of common precipitation methods (salting-out,
isoelectric pH, organic solvents, non-ionic polymers, polyelectrolytes, and affinity interactions).
• Quantitatively describe the kinetics of orthokinetic protein aggregation.
• Specify the operating limits of a precipitate aging process.
Sorption Processes
At the end of this topic, students should be able to:
• Fit adsorption data to Langmuir, Freundlich or linear isotherms.
• Calculate bioproduct recovery in batch adsorption process, given operating and equilibrium
data.
• Explain how various factors could influence the design of a continuous stirred-tank adsorption
process.
• Predict the behaviour of breakthrough curves for various types of adsorption isotherms.
• Calculate breakthrough time and fraction of bed used from supplied data.
• Use the concept of transfer units or theoretical plates to determine the rate-controlling step
from column adsorption experiments.
• Calculate peak resolution and selectivity, and column efficiency, from given chromatographic
results.
• Size chromatographic separation process via productivity analysis of given operating
parameters.
• Identify important engineering properties of chromatographic media.
• Describe the principles of operation of ion exchange and common types of affinity
chromatography.
• Calculate chromatographic distribution coefficient from equilibrium data, and use it to
estimate elution volume from column void volume.
• Describe the principles of operation of size exclusion chromatography, and use the concept of
available distribution coefficient (Kav) to select appropriate media and predict elution volume.
• Apply resolution-related criteria to scale up of chromatographic processes.
• Contrast important requirements of pilot- vs. production-scale chromatographic systems.
• Describe fundamental equipment requirements and basic configuration and operation of
chromatographic systems.
CBE 4403B Course Outline
5
Polishing and Formulation
At the end of this topic, students should be able to:
• Apply mass and enthalpy balances to calculate bioproduct yield and cooling load of
crystallization processes.
• Describe common methods of creating supersaturated solutions.
• Identify principle design considerations in batch crystallization.
• Describe, using suitable examples, the various objectives commonly encountered in
bioproduct formulation.
• Describe the formulation stages in the production of various types of bioproduct.
Evaluation
The final course mark will be determined as follows:
Assignments
20 %
Mid-term Examination
30 %
Final Examination
50 %
The mid-term and final examinations will be open-book examinations.
Note
1) Students must pass the final examination to pass this course. Students who fail the final
examination will be assigned the aggregate mark, as determined above, or the examination mark,
whichever is less.
2) Assignments are to be handed in to the CBE 4403B locker (#462) in TEB on the specified due
date provided by the Instructor.
Repeating All Components of the Course
In accordance with Senate and Faculty Policy, students who have failed an Engineering course (i.e.
<50%) must repeat all components of the course. No special permissions will be granted enabling
a student to retain laboratory, assignment or test marks from previous years. Previously
completed assignments and laboratories cannot be resubmitted for grading by the student in
subsequent years.
Use of English
In accordance with Senate and Faculty Policy, students may be penalized up to 10% of the marks
on all assignments, tests, and examinations for the improper use of English. Additionally, poorly
written work with the exception of the final examination may be returned without grading. If
resubmission of the work is permitted, it may be graded with marks deducted for poor English
and/or late submission.
CBE 4403B Course Outline
6
Attendance
Attendance to all lectures, tutorials and laboratories is mandatory. Any student who, in the
opinion of the instructor, is absent too frequently from class or laboratory periods in any course,
will be reported to the Dean (after due warning has been given). On the recommendation of the
Department concerned, and with the permission of the Dean, the student will be debarred from
taking the regular examination in the course.
Cheating
University policy states that cheating is a scholastic offense. The commission of a scholastic
offense is attended by academic penalties, which might include expulsion from the program. If
you are caught cheating, there will be no second warning (see Scholastic Offence Policy in the
Western Academic Calendar).
Plagiarism
Students must write their essays and assignments in their own words. Whenever students take an
idea or a passage of text from another author, they must acknowledge their debt both by using
quotation marks where appropriate and by proper referencing such as footnotes or citations.
Plagiarism is a major academic offence (see Scholastic Offence Policy in the Western Academic
Calendar).
The University of Western Ontario has software for plagiarism checking. Students may be
required to submit their work in electronic form for plagiarism checking.
Conduct
Students are expected to arrive at lectures on time, and to conduct themselves during class in a
professional and respectful manner that is not disruptive to others.
Sickness and Other Problems
Students should immediately consult with the instructor or Department Chair if they have any
problems that could affect their performance in the course. Where appropriate, the problems
should be documented. The student should seek advice from the Instructor or Department Chair
regarding how best to deal with the problem. Failure to notify the Instructor or Department Chair
immediately (or as soon as possible thereafter) will have a negative effect on any appeal.
Please contact the course instructor if you require material in an alternate format or if any other
arrangements can make this course more accessible to you. You may also wish to contact Services
for Students with Disabilities (SSD) at 661-2111 x 82147 for any specific question regarding an
accommodation.
Notice
Students are responsible for regularly checking their Western email and notices posted on
Instructors' doors.
CBE 4403B Course Outline
7
Consultation
Students are encouraged to discuss problems with their teaching assistant and/or instructor in
tutorial sessions. Office hours will be arranged for the students to see the instructor and teaching
assistants. Other individual consultation can be arranged by appointment with the appropriate
instructor.
Accreditation (AU) Breakdown
Engineering Science
= 100%
October 1, 2010/ch
CBE 4409B Course Outline
1
The University of Western Ontario
Faculty of Engineering
DEPARTMENT OF CHEMICAL AND BIOCHEMICAL ENGINEERING
CBE 4409B – WASTEWATER TREATMENT
COURSE OUTLINE 2009-2010
Description
This course introduces a basic understanding of municipal wastewater treatment processes. The
course reviews pertinent environmental regulations, and general wastewater quality parameters.
Processes and unit operations in wastewater treatment are introduced with particular emphasis
on process design. Considerations in integrating unit processes and operations into a treatment
system are presented.
Prerequisites
CBE 2290a/b or Chemistry 2210a/b.
Unless you have either the requisites for this course or written special permission from your Dean
to enroll in it, you may be removed from this course and it will be deleted from your record. This
decision may not be appealed. You will receive no adjustment to your fees in the event that you
are dropped from a course for failing to have the necessary prerequisites.
Corequisites
None.
Antirequisites
CBE 3363a/b.
Contact Hours
3 lecture hours, 1 tutorial hours, 0.5 course.
Instructor
Dr. G. Nakhla (SEB 3037) Telephone: 519-661-2111 ext: 85470 email: gnakhla@eng.uwo.ca
Undergraduate Assistant
Marilyn Tudhope (TEB 477) Telephone: 519-661-2111 ext: 82131 email: mtudhope@eng.uwo.ca
Required Texts
Ronald L. Droste, "Theory and Practice of Water and Wastewater Treatment", John Wiley and
Sons, 1997.
CBE 4409B Course Outline
2
Reference Texts
Metcalf and Eddy Inc., "Wastewater Engineering: Origins, Characteristics, Treatment", 3rd edition,
McGraw Hill, 1991.
Course Notes
“Water Pollution”, #M7913 will be available in the University Bookstore.
Laboratory Notes
None.
Laboratory
None.
Units
SI units will be used.
General Learning Objectives
Knowledge Base
√
Individual Work
√
Problem Analysis
√
Team Work
x
Investigation
Design
Engineering Tools
x
√
√
Communication
Professionalism
Impact on Society
√
√
x
Ethics and Equity
Economics and Project
Management
Life-Long Learning
Specific Learning Objectives
What is Water Pollution?
• Fundamentals
• Legislation
• Discharge limits in the environment
At the end of this topic, students should be able to gain:
• A fundamental understanding of water pollution.
• An understanding of discharge limits, for pollutants.
• An understanding of the environmental legislation.
Water Pollution Control
• Overview.
• Objectives.
At the end of this topic, students should be able to:
• Describe basic concepts involved in water pollution control.
Physical, Chemical, Biological Characteristics of Pollution
x
x
√
CBE 4409B Course Outline
•
•
•
•
•
•
•
3
BOD, NOD.
COD, TOC, THOD.
VSS, TSS.
MLSS.
MPN.
Toxicity carcinogens.
Coliforms.
At the end of this topic, students should be able to:
• Gain an understanding and describe physical, chemical and biological characteristics for water
pollution.
Preliminary Treatment
Primary Treatment
Biological Treatment
Tertiary Treatment and Disinfection
Natural Treatment, Lagoons
Sludge Treatment and Anaerobic Digestion
At the end of topics 4-9, students should be able to:
• Describe water and wastewater treatment systems for municipalities and industry.
• Suggest and provide initial design of suitable solutions for commercial wastewater pollution
problems.
Evaluation
The final course mark will be determined as follows:
Mid Term Examination
25%
Assignments
25%
Final Examination
50%
Both mid-term and final examinations are open book.
Note
1) Students must pass the final examination to pass this course. Students who fail the final
examination will be assigned 48% if the aggregate mark is higher than 50%, or the aggregate mark.
2) Assignments are to be handed into CBE 4409 (locker # C460) located in the Thompson
Engineering building on the specified due date provided by the Instructor.
CBE 4409B Course Outline
4
Repeating All Components of the Course
In accordance with Senate and Faculty Policy, students who have failed an Engineering course (i.e.
<50%) must repeat all components of the course. No special permissions will be granted enabling
a student to retain laboratory, assignment or test marks from previous years. Previously
completed assignments and laboratories cannot be resubmitted for grading by the student in
subsequent years.
Use of English
In accordance with Senate and Faculty Policy, students may be penalized up to 10% of the marks
on all assignments, tests, and examinations for the improper use of English. Additionally, poorly
written work with the exception of the final examination may be returned without grading. If
resubmission of the work is permitted, it may be graded with marks deducted for poor English
and/or late submission.
Attendance
Attendance at all lectures, tutorials and laboratories is mandatory. Any student, who, in the
opinion of the instructor, is absent too frequently from class or laboratory periods in any course,
will be reported to the Dean (after due warning has been given). On the recommendation of the
Department concerned, and with the permission of the Dean, the student will be debarred from
taking the regular examination in the course
Cheating
University policy states that cheating is a scholastic offence. The commission of a scholastic
offence is attended by academic penalties, which might include expulsion from the program. If
you are caught cheating, there will be no second warning (see Scholastic Offence Policy in the
Western Academic Calendar).
Plagiarism
Students must write their essays and assignments in their own words. Whenever students take an
idea, or a passage from another author, they must acknowledge their debt both by using
quotation marks where appropriate and by proper referencing such as footnotes or citations.
Plagiarism is a major academic offence (see Scholastic Offence Policy in the Western Academic
Calendar).
The University of Western Ontario has software for plagiarism checking. Students may be
required to submit their work in electronic form for plagiarism checking.
Conduct
Students are expected to arrive at lectures on time, and to conduct themselves during class in a
professional and respectful manner that is not disruptive to others.
CBE 4409B Course Outline
5
Sickness and Other Problems
Students should immediately consult with the instructor or Department Chair if they have any
problems that could affect their performance in the course. Where appropriate, the problems
should be documented (see attached). The student should seek advice from the Instructor or
Department Chair regarding how best to deal with the problem. Failure to notify the Instructor or
Department Chair immediately (or as soon as possible thereafter) will have a negative effect on
any appeal.
Please contact the course instructor if you require material in an alternate format or if any other
arrangements can make this course more accessible to you. You may also wish to contact Services
for Students with Disabilities (SSD) at 661-2111 x 82147 for any specific question regarding an
accommodation.
Notice
Students are responsible for regularly checking their email and notices posted on Instructors'
doors.
Consultation
Students are encouraged to discuss problems with their teaching assistant and/or instructor in
tutorial sessions. Office hours will be arranged for the students to see the instructor and teaching
assistants. Other individual consultation can be arranged by appointment with the appropriate
instructor.
Accreditation (AU) Breakdown
Engineering Science = 70%
Engineering Design = 30%
October 4, 2010/ch
The University of Western Ontario
Faculty of Engineering
DEPARTMENT OF CHEMICAL AND BIOCHEMICAL ENGINEERING
CBE 4413B - INTRODUCTION TO NANOBIOTECHNOLOGY
COURSE OUTLINE 2010-2011
Description
Nanobiotechnology is an emerging frontier in nanotechnology. It integrates materials science,
chemical engineering, physics and life science toward the biological and biochemical applications.
This course introduces the fundamental concepts of nanobiotechnology and the up-to-date
application of nanotechnology to life science. In this course, nanofabrication and the interaction
between nanostructured materials and biological system are addressed. Through introducing the
vital information on application of nanotechnology, this course presents how to design and
develop nano-devices for the applications of pharmaceuticals and healthcare. Typical applications
include nano-biosensor, target delivery, and tissue engineering. Students will have chance to
present and discuss individual application through team project.
Course Goals
1. This course aims to strengthen and broaden the skill and knowledge of senior
undergraduate in modern chemical and biochemical engineering.
2. Students will work with each other through team-based activities to facilitate
interdisciplinary collaborations.
Prerequisites
Completion of 3rd year of Engineering in Chemical, Electrical, Civil and Mechanical & Materials
Engineering.
Unless you have either the prerequisites for this course or written special permission from your
Dean to enroll in it, you may be removed from this course and it will be deleted from your record.
This decision may not be appealed. You will receive no adjustment to your fees in the event that
you are dropped from a course for failing to have the necessary prerequisites.
Antirequisites
None.
Contact Hours
3 lecture hours, 1 tutorial, 0.5 course.
Instructor
Dr. J Zhang (TEB 465) Telephone: 519- 661-2111 ext: 88322 email: jzhan283@uwo.ca
CBE 4413B Course Outline
3
Undergraduate Assistant
Marilyn Tudhope (TEB 477) Telephone: 519-661-2111 ext: 82131 email: mtudhop@uwo.ca
Required Text
None.
Reference Texts
“Nanotechnology”, edited by Gregory Timp, editor. (1999) New York: AIP Press.
David S. Goodsell, “Bionanotechnology: lessons from nature”. (2004) Hoboken: Wiley-Liss, Inc.
“Nanobiotechnology: concepts, applications and perspectives”, edited by Christof M. Niemeyer
and Chad A. Mirkin. (2004) Weinheim: Wiley-VCH.
Course Notes
Course notes will be available on the course website.
Laboratory
None.
Units
SI and other engineering units will be used.
General Learning Objectives
Knowledge Base
X
Individual Work
X
Problem Analysis
X
Team Work
X
Investigation
Design
Engineering Tools
X
X
X
Communication
Professionalism
Impact on Society
X
Ethics and Equity
Economics and Project
Management
Life-Long Learning
X
X
X
X
Learning Objectives
• Understand the fundamental concepts of nanotechnology and nanobiotechnology
• Analyze and apply nanofabrication processes
• Interpret the interaction between nanostructured materials and biological system
• Generalize how to apply nanotechnology in the fields of pharmaceuticals and healthcare
• Evaluate regulatory and ethical concerns on nanotechnology used in life science
Topics
Introduction: From Nanotechnology to Nanobiotechnology
Evolution of nanotechnology
Emerging field: Nanobiotechnology
CBE 4413B Course Outline
4
Nanostructured Materials (Nanomaterials)
Basic principles of nanotechnology
Quantum size effect in nanomaterials
Property changes due to nanostructuring
Interaction between Nanomaterials and Biological System
Biological system
Protein-based nanostructures
DNA-based nanostructures
Cell-nanostructure interactions
Nanofabrication and Materials Characterization
Chemical and physical techniques
Nano self-assembly
Nanolithography
X-ray diffraction (XRD)
Electron microscopy (SEM & TEM)
Atomic force microscopy (AFM)
Scanning Tunneling Microscope (STM)
Nanotechnology in Biological and Biomedical Applications
Nanobiosensor
Nanocrystals used in biological imaging
Nanodevice for drug delivery
Design- nanobiosensor devices
Nanotechnology in Tissue Engineering
Applying nanotechnology in scaffolds
Advantages of nanomaterials used for Implants
Design: biocompatible scaffold by applying nanotechnology
Assessing Potential Risks
Perspective Commercializing Nanobiotechnology
Future Nanotechnology used in Life Science
Evaluation
The final course mark will be determined as follows:
Assignments and test
25%
Design
20%
Final exam
55%
Undergraduate students need to finish one design project. All tests and final examination will be
limited-opened book. Only non-programmable pocket calculators will be permitted.
CBE 4413B Course Outline
5
Note
1) Students must pass the final examination to pass this course. Students who fail the final
examination will be assigned 48% if the aggregate mark is higher than 50%, or the aggregate mark.
2) Assignments are to be handed into the CBE 4413B course locker (#458) located in TEB on the
specified due date provided by the Instructor.
Repeating All Components of the Course
In accordance with Senate and Faculty Policy, students who have failed an Engineering course (i.e.
<50%) must repeat all components of the course. No special permissions will be granted enabling
a student to retain laboratory, assignment or test marks from previous years. Previously
completed assignments and laboratories cannot be resubmitted for grading by the student in
subsequent years.
Use of English
In accordance with Senate and Faculty Policy, students may be penalized up to 10% of the marks
on all assignments, tests, and examinations for the improper use of English. Additionally, poorly
written work with the exception of the final examination may be returned without grading. If
resubmission of the work is permitted, it may be graded with marks deducted for poor English
and/or late submission.
Attendance
Attendance at all lectures, tutorials and laboratories is mandatory. Any student who, in the
opinion of the instructor, is absent too frequently from class or laboratory periods in any course,
will be reported to the Dean (after due warning has been given). On the recommendation of the
Department concerned, and with permission of the Dean, the student will be debarred from
taking the regular examination in the course.
Cheating
University policy states that cheating is a scholastic offense. The commission of a scholastic
offense is attended by academic penalties, which might include expulsion from the program. If
you are caught cheating, there will be no second warning.
Plagiarism
Students must write their essays and assignments in their own words. Whenever students take an
idea or a passage from another author, they must acknowledge their debt both by using quotation
marks where appropriate and by proper referencing such as footnotes or citations. Plagiarism is a
major academic offence (see Scholastic Offence Policy in the Western Academic Calendar).
The University of Western Ontario has software for plagiarism checking. Students may be
required to submit their work in electronic form for plagiarism checking.
CBE 4413B Course Outline
6
Sickness and Other Problems
Students should immediately consult with the instructor or Department Chair if they have any
problems that could affect their performance in the course. The student should seek advice from
the Instructor or Department Chair regarding how best to deal with the problem. Failure to notify
the Instructor or Department Chair immediately (or as soon as possible thereafter) will have a
negative effect on any appeal.
Please contact the course instructor if you require material in an alternate format or if any other
arrangements can make this course more accessible to you. You may also wish to contact Services
for Students with Disabilities (SSD) at 661-2111 x 82147 for any specific question regarding an
accommodation.
Notice
Students are responsible for regularly checking their Western email and notices posted on
Instructors' doors.
Consultation
Office hours will be posted. Individual consultation may be arranged by appointment with the
instructor.
Accreditation (AU) Breakdown
Engineering Design = 20%
Engineering Science = 80%
October 1, 2010/ch
The University of Western Ontario
Faculty of Engineering
DEPARTMENT OF CHEMICAL AND BIOCHEMICAL ENGINEERING
CBE 4420B - COMPUTER PROCESS CONTROL
COURSE OUTLINE 2010-2011
Description
The course covers more advanced topics in process control such as Feedforward, Cascade, and
Multivariable Control. Design of multivariable control systems using continuous State Space
Methods is covered. Use of Real Time Process Control Computers for data acquisition and control
are introduced. Discrete Process Control Theory using Z-Transformations is covered in detail for
single input single output processes.
The general objectives of this course are for students to be able to:
• Design process control strategy for variety of industrial applications
• Develop computational abilities to analyse feedback control systems in a variety of
configurations
• Develop tools for testing stability of feedback systems
• Understand the dynamics of Multivariate (MV) systems
• Design feedback control for MV systems based on decoupling
• Develop understanding of Modern State Space Control methods
• Apply feedback control to a real time computer control system
Prerequisites
CBE 3310A/B, GPE 3310A/B or the former CBE 4410A/B.
Unless you have either the requisites for this course or written special permission from your Dean
to enroll in it, you may be removed from this course and it will be deleted from your record. This
decision may not be appealed. You will receive no adjustment to your fees in the event that you
are dropped from a course for failing to have the necessary prerequisites.
Corequisites
None.
Antirequisites
None.
Contact Hours
3 lecture hours, 1 laboratory hour, 0.5 course.
CBE 4420B Course Outline
2
Instructor
Dr. S. Rohani (TEB 457) Telephone: 519-661-2111 ext: 84116 email: srohani@uwo.ca
Undergraduate Assistant
Marilyn Tudhope (TEB 477) Telephone: 519-661-2111 ext: 82131 email: mtudhop@uwo.ca
Required Text
“Process Dynamics and Control”by Seborg, Edgar, Mellichamp, Doyle, 3rd Edition. Wiley 2011.
Reference Texts
“Feedback Control of Dynamic Systems”, G.F. Franklin et al, 4th edition, Addison Wesley, 2002.
“Process Dynamics and Control” Seborg, Edgar and Mellichamp, John Wiley & Sons, New York
2003, 2nd edition.
Course Notes
Course notes will be available for download through the course website. Hand outs will be
provided in class.
Laboratory
The laboratory for this course will take the form of a real time computer control group project.
Students will be arranged into teams and assigned a single project per term.
Control Design Project
Students will be required to implement the control design strategies onto the assigned industrial
process from CBE 4497 course. In-class presentation and a written report of their project will be
mandatory.
Units
SI and British units will be used.
General Learning Objectives
Knowledge Base
Individual Work
Problem Analysis
x Team Work
Investigation
x Communication
x Professionalism
Design
Engineering Tools
x
Ethics and Equity
x
Economics and Project
Management
x
Life-Long Learning
x
Impact on Society
2
CBE 4420B Course Outline
3
General Learning Objectives
The general objectives of this course are for students to be able to:
• Design process control strategy for variety of industrial applications
• Develop computational abilities to analyse feedback control systems in a variety of
configurations
• Develop tools for testing stability of feedback systems
• Understand the dynamics of Multivariate (MV) systems
• Design feedback control for MV systems based on decoupling
• Develop understanding of Modern State Space Control methods
• Apply feedback control to a real time computer control system
Specific Learning Objectives
Process Control Design
At the end of this topic, students will be able to:
• Define the control problem.
• Select Instrumentation.
• Select Controlled and Manipulated Variables .
• Provide sensors for monitoring.
• Implement control for safety.
Closed Loop Systems
At the end of this topic, students will be able to:
• Understand how to manipulate closed loop block diagrams to calculate overall transfer
functions.
• Understand PID control and role integration in offset removal.
• Tune a PID controller by trial and error as well as by using other analytical methods.
• Use Simulink/Matlab tools to develop closed loop tuning simulations.
Stability in Laplace Domain
At the end of this topic, students will be able to:
• Understand the concept of characteristic equation and be able to calculate it for closed loop
systems.
• Apply Routh criteria to analyse the stability of systems without dead time.
Stability in Frequency Domain
At the end of this topic, students should be able to:
• Use Matlab to plot various frequency functions (Bode/Nyquist) for both dead time and nondead time systems.
• Apply Bode/Nyquist stability criteria to dead time chemical processes.
• Use frequency methods to tune controllers.
• Use Matlab commands to analyse stability of complex systems.
3
CBE 4420B Course Outline
4
Feedforward and Ratio Control
Advanced Single-Loop Controllers
At the end of this topic, students will be able to:
• Cascade Control.
• Fuzzy Logic Control.
• Inferential Control.
• Selective Control/Override Systems.
• Adaptive Control Systems.
Multi Variable (MV) Transfer Functions
At the end of this topic, students will be able to:
• Develop a MV Transfer Function Matrix for a MV process.
• Understand Relative Gain Array (RGA) for MV systems.
• Design Decoupling Controllers.
Model Predictive and Real-Time Optimal Control
State Space (SS) and Discrete Systems
At the end of this topic, students will be able to:
• Understand the concept of State Space (SS) Model.
• Conversion between model forms.
• Design of (SS) Controllers using pole placement.
• Design of State Estimators.
• Use of Matlab Control Toolbox for SS and discrete design.
Evaluation
The Computer Process Control Laboratory has a number of processes interfaced to real time
computers. A series of goals will be set for the group and a comprehensive project report will be
used to assess the group and individual performance. Simulation projects using Matlab + Simulink
are also available.
The final course mark will be determined as follows:
Laboratory
15%
Assignments
10%
Control Design Project
10%
Mid-term Examination
15%
Final Examination
50%
Examinations will be closed book. A formula sheet is allowed. Calculators of any kind will be
permitted during examinations. The memory of the calculators should be purged before the
examination.
4
CBE 4420B Course Outline
5
Notes
1) Students must pass the final examination to pass this course. Students who fail the final
examination will be assigned 48% if the aggregate mark is higher than 50%, or the aggregate mark.
2) Students must turn in all laboratory reports, and achieve a passing grade in the laboratory
component, to pass this course.
3) Assignments are to be handed in the CBE 4420 locker (#456) located in TEB on the specified
due date provided by the Instructor.
Repeating All Components of the Course
In accordance with Senate and Faculty Policy, students who have failed an Engineering course (i.e.
<50%) must repeat all components of the course. No special permissions will be granted enabling
a student to retain laboratory, assignment, control design project, or test marks from previous
years. Previously completed assignments and laboratories cannot be resubmitted for grading by
the student in subsequent years.
Use of English
In accordance with Senate and Faculty Policy, students may be penalized up to 10% of the marks
on all assignments, tests, and examinations for the improper use of English. Additionally, poorly
written work with the exception of the final examination may be returned without grading. If
resubmission of the work is permitted, it may be graded with marks deducted for poor English
and/or late submission.
Attendance
Attendance in all lectures, tutorials and laboratories is mandatory. Any student, who, in the
opinion of the instructor, is absent too frequently from class or laboratory periods in any course,
will be reported to the Dean (after due warning has been given). On the recommendation of the
Department concerned, and with the permission of the Dean, the student will be debarred from
taking the regular examination in the course.
Cheating
University policy states that cheating is a scholastic offence. The commission of a scholastic
offence is attended by academic penalties, which might include expulsion from the program. If
you are caught cheating, there will be no second warning (see Scholastic Offence Policy in the
Western Academic Calendar).
Plagiarism
Students must write their essays and assignments in their own words. Whenever students take an
idea or a passage from another author, they must acknowledge their debt both by using quotation
marks where appropriate and by proper referencing such as footnotes or citations. Plagiarism is a
major academic offence (see Scholastic Offence Policy in the Western Academic Calendar).
The University of Western Ontario has software for plagiarism checking. Students may be
required to submit their work in electronic form for plagiarism checking.
5
CBE 4420B Course Outline
6
Conduct
Students are expected to arrive at lectures on time, and to conduct themselves during class in a
professional and respectful manner that is not disruptive to others.
Sickness and Other Problems
Students should immediately consult with the instructor or Undergraduate Chair if they have any
problems that could affect their performance in the course. Where appropriate, the problems
should be documented. The student should seek advice from the Instructor or Undergraduate
Chair regarding how best to deal with the problem. Failure to notify the Instructor or
Undergraduate Chair immediately (or as soon as possible thereafter) will have a negative effect on
any appeal.
Please contact the course instructor if you require material in an alternate format or if any other
arrangements can make this course more accessible to you. You may also wish to contact Services
for Students with Disabilities (SSD) at 661-2111 x 82147 for any specific questions regarding an
accommodation.
Notice
Students are responsible for regularly checking their Western email and notices posted on
Instructors' doors.
Consultation
Students are encouraged to discuss problems with their teaching assistant and/or instructor in
tutorial sessions. Office hours will be arranged for the students to see the instructor and teaching
assistants. Other individual consultation can be arranged by appointment with the appropriate
instructor.
Accreditation Unit (AU) Content
Engineering Science =
60%
Engineering Design =
40%
October 1, 2010/ch
6
The University of Western Ontario
Faculty of Engineering
DEPARTMENT OF CHEMICAL AND BIOCHEMICAL ENGINEERING
CBE 4432B - OIL REFINING AND PROCESSING
COURSE OUTLINE 2010-2011
Description
An introduction to petroleum refining processes, operations, feedstocks and products.
Configurations of refinery processes and their evolution will be discussed in view of
environmental efficiency and economic considerations. Current trends and future of the industry
will be addressed.
Prerequisites
CBE 2206A and CBE 2207B or the former 2216 or Chemistry 2213A/B and 2223B, or GPE 2213A/B
and GPE 2218A/B, CBE 2224A/B or the former CBE 314A/B, CBE 3315A/B.
Unless you have either the requisites for this course or written special permission from your Dean
to enroll in it, you may be removed from this course and it will be deleted from your record. This
decision may not be appealed. You will receive no adjustment to your fees in the event that you
are dropped from a course for failing to have the necessary prerequisites.
Corequisites
None.
Antirequisites
None.
Contact Hours
3 lecture hours, 1 tutorial hour, 0.5 course.
Instructor
Dr. S. Barghi (TEB 447) Telephone: 519-661-2111 ext: 81275 email: sbarghi2@uwo.ca
Undergraduate Assistant
Marilyn Tudhope (TEB 477) Telephone: 519-661-2111 ext: 82131 email: mtudhop@uwo.ca
Required Text
None.
Reference Text
J.H. Gary and G. E. Handwerk “Petroleum Refining Technology and Economics”, 4th Ed.Marcel
Dekker, Inc., 2001.
CBE 4432a/b Course Outline
2
Course Notes
Course notes will be available for download through the course web site. Handouts will be
provided in class.
Lab Notes
None.
Laboratory
None.
Units
SI units will be used in reports with British Engineering units between brackets.
General Learning Objectives
Knowledge Base
x
Individual Work
Problem Analysis
Team Work
Investigation
Design
Engineering Tools
Communication
Professionalism
Impact on Society
x
x
x
x
x
Ethics and Equity
Economics and Project
Management
Life-Long Learning
x
General Learning Objectives
The general objectives are for the students to be able to:
• Become knowledgeable in composition, properties and classification of crude oil or petroleum.
• Become familiar with operations and processes in petroleum processing as well related
chemistry and catalysis.
• Become knowledgeable about impurities in crude oil and how to remove them from products.
• Develop understanding of refinery products and their specifications.
• Develop understanding of safety and environmental issues in petroleum refining.
• Search the academic and technical literatures for information on the selected process area to
present in formal report.
Specific Learning Objectives
Introduction to the Petroleum Industry
At the end of this section, students should be familiar with:
• History and origin and occurrence of crude oil.
• Exploration, recovery and transportation of crude oil.
CBE 4432a/b Course Outline
3
Feedstocks and Products Composition, Properties and Specifications
At the end of this section, students should become familiar with:
• Composition and classification of crude oil.
• Physical properties such as gravity, pour point and impurities level in petroleum.
• Specifications of main products from petroleum refinery i.e. gasoline, diesel, kerosene, fuel oil
etc.
Crude Distillation
At the end of this section, students should become familiar with:
• Typical fraction cuts and boiling ranges for atmospheric and vacuum still fractions.
• Flow diagrams of atmospheric topping unit and vacuum distillation units.
Catalytic Cracking and Hydrocracking
At the end of this section, students should become familiar with:
• Chemistry and catalysis of catalytic cracking and hydrocracking reactions.
• Fluidized bed catalytic cracking (FCC) and hydrocracking unit configurations.
• Process variables, heat recovery, yield estimation.
Catalytic Reforming and Isomerization
At the end of this section, students should become familiar with:
• Chemistry and catalysis of catalytic reforming and isomerisation.
• Catalytic reforming and isomerization processes with process variables and yields.
Alkylation and Polymerization
At the end of this section, students should develop understanding of:
• Alkylation feedstocks, reactions, catalysts and products.
• Various alkylation processes and their comparison.
• Polymerisation processes to make high-octane gasoline product.
Coking and Thermal Processes
At the end of this section, students should be able to:
• Process descriptions and review – delayed coking, flexicoking, fluid coking, visbreaking.
• Process variables, products propertied and yields .
Safety, Loss Prevention and Environmental Analysis
At the end of this section, students should be able to:
• Become knowledgeable about safety and health hazards in petroleum refinery i.e. fire and
explosion hazard, accidental release.
• Develop understanding of fugitive emissions, loss prevention during storage and handling of
products.
• Become familiar with acids gas removal, sulfur recovery processes, waste water treatment in
refinery.
CBE 4432a/b Course Outline
4
Evaluation
The final course mark will be determined as follows:
Project Report
15%
Presentation
10%
Final Examination
75%
Final Examination will be closed book.
Note
1) Students must receive a passing grade on the final report to pass this course. Students who
fail the final report will be assigned 48% if the aggregate mark is higher than 50%, or the aggregate
mark.
2) A minimum mark of 50% is required for the safety examination.
3) Assignments are to be handed in to the CBE 4432B locker (#454) located in TEB on the
specified due date provided by the Instructor.
Repeating All Components of the Course
In accordance with Senate and Faculty Policy, students who have failed an Engineering course (i.e.
<50%) must repeat all components of the course. No special permissions will be granted enabling
a student to retain laboratory, assignment or test marks from previous years. Previously
completed assignments and laboratories cannot be resubmitted for grading by the student in
subsequent years.
Use of English
In accordance with Senate and Faculty Policy, students may be penalized up to 10% of the marks
on all assignments, tests, and examinations for the improper use of English. Additionally, poorly
written work with the exception of the final examination may be returned without grading. If
resubmission of the work is permitted, it may be graded with marks deducted for poor English
and/or late submission.
Attendance
Any student who, in the opinion of the instructor, is absent too frequently from class or laboratory
periods in any course, will be reported to the Dean (after due warning has been given). On the
recommendation of the Department concerned, and with the permission of the Dean, the student
will be debarred from taking the regular examination in the course.
Cheating
University policy states that cheating is a scholastic offence. The commission of a scholastic
offence is attended by academic penalties, which might include expulsion from the program. If
you are caught cheating, there will be no second warning (see Scholastic Offence Policy in the
Western Academic Calendar).
CBE 4432a/b Course Outline
5
Plagiarism
Students must write their essays and assignments in their own words. Whenever students take an
idea or a passage from another author, they must acknowledge their debt both by using quotation
marks where appropriate and by proper referencing such as footnotes or citations. Plagiarism is a
major academic offence (see Scholastic Offence Policy in the Western Academic Calendar).
The University of Western Ontario has software for plagiarism checking. Students may be
required to submit their work in electronic form for plagiarism checking.
Conduct
Students are expected to arrive at lectures on time, and to conduct themselves during class in a
professional and respectful manner that is not disruptive to others.
Sickness and Other Problems
Students should immediately consult with the instructor or Department Chair if they have any
problems that could affect their performance in the course. Where appropriate, the problems
should be documented. The student should seek advice from the Instructor or Department Chair
regarding how best to deal with the problem. Failure to notify the Instructor or Department Chair
immediately (or as soon as possible thereafter) will have a negative effect on any appeal.
Please contact the course instructor if you require material in an alternate format or if any other
arrangements can make this course more accessible to you. You may also wish to contact Services
for Students with Disabilities (SSD) at 661-2111 x 82147 for any specific question regarding an
accommodation.
Notice
Students are responsible for regularly checking their Western email and notices posted on
Instructors' doors.
Consultation
Students are encouraged to discuss problems with their teaching assistant and/or instructors in
tutorial sessions. Office hours will be arranged for the students to see the instructor and teaching
assistants. Other individual consultations can be arranged by appointment with the appropriate
instructor.
Accreditation (AU) Breakdown
Engineering Science =
80%
Engineering Design =
20%
October 4, 2010/ch