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Fighting bacteria?s strength in numbers
May 19, 2012 by unirachaa | 0 comments
ScienceDaily (May 17, 2012) ? Scientists at The University of Nottingham have opened the way for more accurate research into new ways to fight dangerous bacterial
infections by proving a long-held theory about how bacteria communicate with each other.
Researchers in the University’s School of Molecular Medical Sciences have shown for the first time that the effectiveness of the bacteria’s communication method, a
process called ‘quorum sensing’, directly depends on the density of the bacterial population. This work will help inform wider research into how to stop bacteria talking to
each other with the aim of switching off their toxin production.
As some pathogenic organisms are increasingly resistant to traditional antibiotics, medical researchers around the world, including scientists at The University of
Nottingham, are trying to find other ways of fighting infection. This new work involves using ‘quorum quenching’ compounds which interfere with bacterial signalling
and disrupt their social lives.
Quorum sensing (QS) is the process by which bacteria communicate and co-operate using signal molecules which control, among other things, the production of toxins.
QS is therefore an important factor in a number of bacterial species that cause serious infection in humans including Pseudomonas aeruginosa, a leading cause of death
among cystic fibrosis sufferers, and MRSA which is a huge clinical problem in hospitals.
Leading the research at Nottingham, Dr Stephen Diggle said: “The fundamental assumption used to explain QS, is that the production of QS-controlled factors is not
beneficial until a sufficient density of cells (a quorum) is present, and that the purpose of QS is to stimulate social behaviours only when high enough bacterial population
densities are reached. For a pathogen this makes sense. Why produce toxins when there are not many cells around? Why not wait until a large number are present and
coordinate production of toxin on mass which helps to overwhelm a host? This density assumption, upon which the entire QS field is based, has never been
experimentally tested until now.”
This ground-breaking research has just been published in the leading international journal, Proceedings of the National Academy of Sciences. It shows for the first time
that cell density is an important factor in regulating QS in the opportunistic pathogen Pseudomonas aeruginosa. Using a combination of special growth media and
molecular techniques, the work has shown that QS signalling occurs in low populations of cells but that there is no benefit to the bacteria of doing so. QS is therefore most
useful to the bacteria at high cell densities.
A challenge for researchers in the future is to study this in more natural environments such as infections. Bacteria such as P. aeruginosa use QS to control toxin production
and this new research helps to explain how certain infections can suddenly turn life threatening due to massive toxin release. This suggests that carefully controlling
bacterial population density within infections could be helpful in avoiding toxin-related damage.
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Story Source:
The above story is reprinted from materials provided by University of Nottingham, via AlphaGalileo.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
1. S. E. Darch, S. A. West, K. Winzer, S. P. Diggle. Density-dependent fitness benefits in quorum-sensing bacterial populations. Proceedings of the National
Academy of Sciences, 2012; DOI: 10.1073/pnas.1118131109
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its
staff.
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Fighting bacteria?s strength in numbers | Britney Spears New Video
27/05/2012 21:13
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Categories: unmistakable | Tags: density, social behaviours, traditional antibiotics | Permalink
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