Potential Collaborators at SUMC * * Shaded entries indicate external members with primary appointment at another institution Au, William Au, William william.au@utmb.edu PhD(77) Chair, Preventative Medicine SUMC (since Oct 09) CHEN HL 陈鸿霖 hlchen@hkucc.hku.hkPhD(92) Assoc Prof Dept. of Microbiology, The Univeristy of Internatioanl Institute of Infection and Molecular Virology and molecular mechanism Hong Kong; visiting Prof @ SUMC since 04 Immunity for viral pathogenesis Preventive Medicine FU YC 傅玉才 ycfu@stu.edu.cn PhD Lyon (99) Professor, Head Dpt Pathogenic Biology since 2000 Pathogenic Biology GU Jiang 顾江 jguemailbox@gmail.c MD (77) PhD (84) Dean, SUMC; Dean School Basic Medical Sciences (Beijing) since 03 Pathology and Pathophysiology 顾巍 MD (89); ggwxnldl@126.com PhD(96) GU Wei GUAN Y 管轶 yguan@hkucc.hku.hk MD(83) PhD (97) HUANG DY 黄东阳 huangdy@stu.edu.cn MD(84)PhD (97) HUANG TH 黄天华 thhuang@stu.edu.cn M.Med(82) HUO X Kelvin, David 霍霞 Kelvin, David xhuo@stu.edu.cn dkelvin@jidc.org Prof Dept Pathophysiology SUMC Pathophysiology 1. Professor, Department of Microbiology, Faculty of LSK Medicine, The University of Hong Kong; 2. Director, State Key Laboratory for Emerging Infectious Diseases, The University of Hong Kong; Division of Infection, International 3. Visiting Professor since 2000, Division Director, Institute of Infection and Immunity, Division of Infection, International Institute of Shantou University Medical College Infection and Immunity, Shantou University Medical College Professor, Cell Biology SUMC since 2002; Assoc Dean SUMC Professor Medical Biology and Genetics SUMC; Director Center for Reproductive Medicine Cell Biology Biochemistry and Molecular Biology BScMed(83); PhD(98) Professor and Director Analytical Cytology lab PhD (87) Senior Scientist and Division Head, Experimental Therapeutics, TGRI, UHN, Toronto; Professor, Dept of Microbiology and Immunology, Uni. of Toronto; Division of Immunology, International Visiting professor, Uni. of Sassari, Italy; Visiting Institute of Infection and Immunity professor, SUMC since 07; Scientific Director, Division of Immunology, IIII, SUMC since 07; Senior Editor, Journal of Infection in Developing Countries. Analytical Cytology lab LI EM 李恩民 nmli@stu.edu.cn PhD(97) Director Biochemistry SUMC LI KS 李康生 ksli@stu.edu.cn MD PhD(89) Professor and Chairman, Micro and Immuno SUMC Immunology Schachner, Melitta Schachner, Melitta Schachner, Melitta <SPhD ('70) Professor Rutgers U; Director of Neurobiology, UHamburg since '97; Director, SUMC Neuroscience Neuroscience Center (since '08) SHI GG 石刚刚 Professor and Director Dept Pharmacology, SUMC ggshi@stu.edu.cn PhD (92) Biochemistry and Molecular Biology Pharmacology Toxicology; Environmental Health Cell senescence; the mechanism of calorie restriction in longevity and prevention of agerelated diseases; sirtuin and IGF signaling Extra lymphoid expression of immunoglobulin, pathogenesis of newly emerged infectious diseases, telepathology, cancer pathogenesis Toxicology, genetics, molecular genetics Influenza virus, Epstein-Barr virus and coronavirus Gene regulation Molecular pathology, molecular biology, cell biology, molecular morphology Regulation of gene expression; RNA localization Molecular and cell biology, transcriptional and translational control, RNA-protein and and translation, tumor metastasis protein-protein interaction 1. Molecular Virology, Ecology, and Epidemiology of influenza A viruses in southern China 2. Identification of the emergency of animal influenza viruses with pandemic potential 3. Ecology of SARS Transcriptional regulation of DHRS4 gene by Natural antisense transcripts Reproductive genetics; transmission of infective viruses via germ line Environment medicine; toxicology; epidemiology; developmental toxicity; children health Prof. Guan Yi is a virologist and an avian flu expert who had set up and maintained a systematic influenza surveillance network in human, poultry and migratory bird populations in Southern China. The information from this surveillance program has provided the most comprehensive understanding of the ecology, evolution and dissemination of avian influenza viruses with pandemic potential. In addition, Prof. Guan contributed greatly to clarify the evolution pathway of highly pathogenic H5N1 influenza A viruses through phylogenetic, antigenic analysis and genotyping. His research also included pathogenicity studies, crossspecies transmission studies, and identification of emerging infectious diseases. His work to identify the infectious source of SARS coronavirus at the live-animal markets in southern China directly contributed to contain this highly infectious disease. Chip, DNA methylation, qPCR, Protein purification by HPLC, FPLC. Gene cloning, Recombination and expression. Reproductive Medicine Genetics Electron microscopy; confocal; flow cytometry; GFAAS; GC/MS, Immunohistochemistry, Cell Biology and Molecular Biology techniques, et al Characterization of the immune responses during infection with respiratory viruses, including Animal models of influenza infection, microarray analysis SARS and different influenza strains, in both human patients and animal models. Molecular mechanisms of cytoskeletonassociated proteins regulating the mobility, invasiveness and metastasis of human cancer cells. Expression, transcription regulation, signal transduction and functional roles of actinbundling proteins such as Ezrin and Fascin in esophageal squamous cell carcinomas. 1) Biochemical and Molecular Biology techniques: gene clone; construct of recombination vector; protein-protein interaction; RNAi; qRT-PCR; Western blotting; Coimmunoprecipitation; report gene analysis; cell signal analysis; gene mutation and so on. 2) Cell Biology: cell culture; transfection; cell mobility and invasion analysis; clone formation; BrdU assay; F-actin assay; Immunofluorescence and so on. 3) Bioinformatics: general primer and methylation primer design; BLAST and other biological soft ware. 4) Immunohistochemistry. Anti-infection immunity; neuroendocrine immunity The role of glial cells in viral encephalits; pathogenesis of influenza; Interaction between influenza virus and host innate immunity; Brain cytokine response. Investigations on the cellular and molecular mechanisms of cell-to-cell and cell-toextracellular matrix interactions during nervous system development as well as in synaptic recognition molecules in nervous system plasticity (learning and memory) and regeneration after trauma in the adult vertebrate development, synaptic plasticity and regeneration nervous system. the elucidation of the functions of recognition molecules and their glycans after injury has wider implications: they are not only essential during these processes, but also play crucial functional roles in the immune system, tumor metastasis, angiogenesis, and pathogenhost interactions Cardiac pharmacology, Chinese herbal medicine Cardiac pharmacology, Chinese herbal medicine Potential Collaborators at SUMC * * Shaded entries indicate external members with primary appointment at another institution MBBS(82) MscMed(89) Professor and Director Dept Pathology SUMC PhD advisor(02) SU M 苏敏 minsu@stu.edu.cn Wang YY 王永煜 yywangut@gmail.comPhD (05) Professor SUMC since 09 Pathology and Pathophysiology Oncopathology, genetic pathology Research goals include: 1. To identify the genes that underlie susceptibility to esophageal cancers.2. To elucidate the spectrum of rare and common genetic variation that underlies susceptibility.3. To develop phenotypic assays that are practicable on an epidemiological scale and the biological maker in the malignant transformation to assist in the search for these genes. 4. To explore the use of genetic information to define groups at different risk in the population, and so to design programmes of screening and prevention. oesophageal cancer Pathology and Pathophysiology GPCR signalling, cardiology Biochemistry and Molecular Biology The molecular biology and molecular pathology of cancer. Current research is focused on 1) the cloning, identification and transcription regulation mechanisms of tumor-related genes; 2) the identification of new markers for early diagnosis, prognosis and molecular types of cancers, specially, esophageal squamous cell carcinoma (ESCC); 3) the target gene identification and transcription regulation mechanisms of microRNA in ESCC cells; 4) the molecular mechanism of FW04-806,an antibiotic, inhibiting tumor growth and invasion in ESCC cells. XU LY 许丽艳 liyanxu1130@yahoo.cPhD (06) Professor ZENG QY 曾庆余 qyzeng@stu.edu.cn MD (68) Professor of Medicine, Director, Dept Rheumatology Immunology ZHANG GZ 张国君 guoj_zhang@yahoo. MD (95) PhD (99) Professor of Surgery, Director Cancer Hospital ZHANG H 张灏 zhangendo@gmail.c MD(84) PhD (99) ZHANG MZ 张铭志 zmz@jsiec.org ZHOU YB 周应毕 zhouyingbi35@gmai ZHU Y 朱毅 MD(83); MSc yizhuucr@yahoo.com (86) MD (93) WU RH 吴仁华 cjr.wurenhua@vip.1 TAN XR 谭学瑞 Professor; Chief physician tanxuerui@vip.sina MD(94);PhD(97) President of the First Affiliated Hospital of SUMC .com 1) Conventional pathology & Forensic pathology ( Medical License &Forensic Medicine License in China); tumor tissue bank 2) Immunohistochemistry & In situ hybridization: double-labeling 3)Immunofluorescence & FISH 4) STR SNP Genotyping: Genome-Wide Scan Linkage analysis, association study and relative Bioinformatics: PGA,CaT, SHEsis, Snagger, Beagle, Haploview, Plink, Eigensoft, Structure, Primer Premier, Oligo, SequenceSanner, DNAStar, Phred, Phrap, Consed Software 5) Conventional Cellular and molecular biology: tumor cell culture & neural stem cell culture, DNA RNA Extraction, PCR; Western blotting, primer design, construction of protein expression vectors 6) Cancer registration system &GeneticEpidemiology : S.A.G.E Software 7) Animal experiments Cloning,cell culture,western,IF 1) Biochemical and Molecular Biology techniques: gene clone; construct of recombination vector; RNAi; qRT-PCR; Western blotting; Co-immunoprecipitation; report gene analysis; EMSA; ChIP; gene mutation and so on. 2) Cell Biology: cell culture; transfaction;Immunofluorescence and so on. 3) Epigenetics: methylation analysis including BSP and MSP 4) Bioinformatics: general primer and methylation primer design; BLAST and other biological soft ware. 5) Immunohistochemistry. Early diagnosis of Ankylosing spondylitis; Pathology of Ankylosing spondylitis; Pharmacogenetics in rheumatology Clinical Rheumatology; Needle biopsy of sacroiliac joint Oncology Breast cancer; biomarkers; in vivo optical imaging 1. Excellent in the research of invasion and metastasis of breast cancers; the development of tumor biomarkers. 2. generation of reporters for in vivo optical imaging and its applicatiotn in anti-cancer drug discovery Professor, Director of Cancer Research Center Vice director of Cancer Hospital Director of Tumor Tissue Bank of Cancer hospital Cell Biology and Molecular Biology 1.Tumor metastasis; 2.Cancer therapy resistance and individualized therapy; 3.Cancer stem cell; 4. Cancer types: breast, esophageal and ovarian cancers 1.Genetically engineered murine model: transgenic and knockout; 2.Epigenetics; 3.Cell biology and Molecular Biology of nuclear receptor and co regulators (transcription and protein-protein interaction); 4.Developmental biology of mammary gland and other organs; 5.Tissue bank and tissue array; 6.Analysis of circulating markers for cancer patients MD (94) Professor, vice-executive director Int. Eye Centre since '05 ophthalmology 1. glaucoma neuroprotection 2.cataract 3.optometry 1.cataract 2.glaucoma MD (84), PhD (98) PDF (2000-05); Professor, SUMC Cardio vascular Res Ctr since 2009.1 Pathology and Pathophysiology Cardiology Mouse models of vascular diseases, functional analysis of mouse vessels Professor Peking University since 10/03; Professor Director Cardio vascular Res Ctr SUMC since 4/08 Pathology and Pathophysiology Cardiovascular research, Diabetes Vascular biology, Molecular mechanism of atherogenesis and hypertension, Metabolism of eicosanoids and cardiovascular diseases Professor and Director, Department of Medical Imaging Medical Imaging Noninvasive biomaker of cell and tissue using MRS;Noninvasive quantitation of metabolites High resolution MR spectroscopy, Magnetic resonance technology using MRS; Noninvasive MR pH imaging; MRS features of neurodegenerative diseases Cardiolology Cardiovascular disease M.med(88), Dr.med(97) clinical and epidemiological research of cardiovascular disease