EDITOR’S NOTE: Editor’s note: There is a great feeling of anticipation as the first phase of the new Science Building takes shape outside our windows on the north side of Moody. The new construction will create a biochemistry/molecular biology research and teaching lab space. This area epitomizes the over-arching vision for the science building, to build the opportunities for interaction between different disciplines. To this end, the biochemistry/molecular biology research labs involve shared spaces and equipment between chemists and biologists. This theme is carried to the teaching labs, with the first year biology and chemistry labs next to each other, with students moving seamlessly between chemistry and biology. The new space will have research labs for three chemists with a seminar room built with the utilities to allow it to be converted into a research lab if the faculty size increases. There will be a new organic chemistry teaching lab, and space for our two NMR spectrometers, a new 500 MHz NMR spectrometer acquired with Major Research Instrumentation funding from the National Science Foundation, and a 300 MHz NMR spectrometer, also funding in part with funding from NSF and from the Dreyfus Foundation. The second NMR spectrometer serves dual duty, providing access to NMR data for the two-year colleges in San Antonio, as well as to Trinity students and researchers. When the new building is finished in December 2011, Moody will be demolished and replaced with a new building that will house the remaining chemistry research and teaching labs, and the departments of Engineering Science and Computer Science. Again the interdisciplinary focus is clear, with several chemistry and engineering science research labs in close proximity. The entire complex, to be called the Center for Science and Innovation, will contain a design space that is intended for use by the entire Trinity community, to serve as a type of incubator that will take advantage of our size to encourage the kinds of interactions between diverse departments that would be much more difficult at a larger institution. You can follow this link to more information about the Center for Science and Innovation: http://web.trinity.edu/x7162.xml Don't forget to use the link to the science cam, a live view of the construction from a camera on the roof of Moody. We are planning a celebration during alumni weekend this year to say good bye to Moody, and another in 2014 to welcome the new building. Stay posted for more information. To keep in touch with other alums, look for the facebook page, http://www.facebook.com/home.php#!/home.php?sk=group_161512913892741&ap =1, or Google facebook chemistry department alumni. Nancy Mills 1 2010 ANNUAL REPORT ......................... TRINITY UNIVERSITY DEPARTMENT OF CHEMISTRY Contents Table of Contents 2 Report from the Chair/Sr. picture 3 2010 Senior Graduates in Chemistry 4 5 2010 Student Research Activities and Groups 2 26th Summer Research Symposium 15 Student Research Presentations 16 Chemistry Department Awards 18 Chemistry Club 21 Reports from the Faculty and Staff 23 Grants for Education and Research And Faculty Research Grants 36 Faculty Publications 39 Faculty Presentations/Seminars 41 Seminar Series 44 Major Equipment 46 Board of Advisors 48 Alumnet 49 Acknowledgments 49 REPORT FROM THE CHAIR As I look out of my office window, I see the major accomplishment of 2010 – the first phase of the Center for Sciences and Innovation is under construction! This phase, which will be completed in December 2011, will house much of chemistry and biology. When you enter the building coming from the library, you will pass through a beautiful 3 story atrium and straight ahead of you will be the general chemistry and introductory biology labs side by side. This is a symbol of the integration of the sciences that marks the philosophy of the new center. Our students will be trained for sciences in the 21st century, where interdisciplinarity is essential. On the next floor up you will find the biochemistry and molecular biology suite, encompassing a teaching laboratory that will be shared by chemistry and biology along with a number of research labs. On the top floor will be the state-of-the-art organic teaching lab with great sight lines, a magnificent large lecture hall overlooking the trees and fountains in front of Chapman, and chemistry research labs. Planning is currently underway for the next phase of the project which includes renovating Cowles and demolishing Moody and replacing it with a new structure. This project should begin early in 2012. So exciting changes are underway! We welcomed Professor Joseph Lambert to the department in October. Joe retired from a very successful career as a physical organic chemist at Northwestern University and will teach occasionally and mentor students in the summer. We are very excited to have him here. For more information see p. 24. The Department is grateful for the many gifts from our alumni that continue to allow us to deliver an outstanding education to our students. We want to welcome everyone to visit and see the new building. Look for a grand opening celebration early in 2012. Steven Bachrach 3 2010 CHEMISTRY/BIOCHEMISTRY/ BIOCHEMISTRY MOLECULAR BIOLOGY MAJORS Brown Nathan BS.BICM/MB Applying to Med School Bushe Bryce BS.BICM/MB Chinai Jordan BS.BICM Albert Einstein College of Medicine's Medical Scientist Training Program Eisenheimer Kaitlyn BS.BICM/MB Gann Lauren BS.CHEM Applying Med School Handley Lindsey BS.CHEM UC San Diego, PhD, Biochem Columbia University MS, Hartshorn Heather BA.CHEM Historic Preservation Khalid Mohammed BS.BICM/MB UT Houston, med school Mullings Graham BS.CHEM SGS, research chemist Scripps Research Institute, Rainbolt Thomas BS.BICM/MB PhD, Biochem Schardon Christopher BS.BICM Research at Trinity, Grad school 2011 Scott Erica BS.BICM/MB Smith Derek BS.CHEM Texas Tech, med school Shaw Porsha BS.BICM Duke, PhD, Biochemistry Stück David BS.CHEM UC Berkeley, PhD, Chemistry Tielleman Thomas BS.BICM/MB UT Southwestern, med school Tresca Blakely BS.BICM Grad School in 2011 Whitney Emily BS.BICM U of Georgia Pharmacy School Wilbanks Cecily BS.BICM RPI, grad school Wilkes John BS.BICM/MB LSU, med school 1st row:Lauren Gann, Lindsay Handley, Porsha Shaw, Cecily Wilbanks, Kaitlyn Eisenheimer, Emily Whitney, Chris Shardon 2nd row:Derek Smith, Jordan Chinai, John Wilkes, Blake Tresca, Kelly Rainbolt, Tom Tiellerman, David Stück, Bryce Bushe, Graham Mullings 4 STUDENT RESEARCH ACTIVITIES Bachrach Research Group Michael Cammarata, Maduka Ogba, Dr. Steven Bachrach, David Shope Michael Cammarata (2011) studied the curcurbit[8]uril-methyl violagen-tyrosine complex with a variety of density functionals. He plans to pursue a doctorate in chemistry. Maduka Ogba (2011) examined the Diels-Alder reactions of 3-vinyl-1,3-butadiene, the simplest dendralene, with DFT. He plans to pursue his doctorate in bio/cheminformatics. David Shope looked at the microsolvation of aspartic acid with DFT. David plans to attend graduate school after graduation in Dec. 2011. 5 Bushey Research Group Zoe LaPier, Michael Dzierlenga, Dr. Michelle Bushey, Christopher Schardon Chance Bauman, a 2010 graduate of the John Jay High School of Science and Mathematics joined the lab for the summer while supported by Project SEED. He worked on the identification of flavonoids in plant seedling extracts. In August he headed to Texas A&M. Michael Dzierlenga (2011) joined the lab in the summer and was supported by the Departmental Welch grant. He worked on measuring diffusion coefficients of analytes on porous polymer monoliths. Michael is applying to chemistry graduate programs. Zoe LaPier (2011) continued her work on measuring diffusion coefficients of analytes on porous polymer monoliths in the spring and summer. During the summer she was supported by the Departmental Welch grant. She is currently applying to Teach for America. Trisha Patel (2013) joined the lab in the fall semester. She spent the semester learning the basics of the porous polymer monolith project. Si Ying Li-Gonzalez (2013) joined the lab in the fall semester. She spent the semester learning the basics of the porous polymer monolith project. Christopher Schardon (2010) worked in the lab in the spring and summer on the identification of compounds that change when cucumber and Arabidopsis seedlings are exposed to UV light. He received HHMI support in the summer. He graduated in Dec. and is currently applying to biochemistry graduate departments. 6 Chandler/Pursell Research Group Dr. Christopher Pursell, Tim Ward, Kendall Bailey, PJ Pritzker, Dr. Bert Chandler Tim Ward (2012, BS Chemistry) started working with Drs. Pursell and Chandler at the beginning of the year, studying CO adsorption on Au nanoparticle catalysts. In between world cup matches, he continued his work over the summer and fall, extending it to some Pd-Au catalysts prepared by our collaborators in Paris. PJ Pritzker (2012, Math and Chemistry) worked on methods for preparing high surface area transition metal oxide supports, as well as preparing Au catalysts on these new supports. He has also been studying CO oxidation over Pd and Pd-Mo catalysts prepared by our collaborators in Austin. Kendall Bailey (2013, Computer Science) performed detailed CO oxidation kinetics studies of several Au catalysts, working out activation conditions as she progressed. Importantly, she cultured-up the lab by introducing us to a variety of east-asian pop music. Clark Moehlenbrock (2012, Chemistry) joined the group in the fall and began working on amide synthesis reactions. Playing on the men’s club team, he is picking up the volleyball torch from his advisor. 7 Hollenbeck Research Group Daren Danner, Colin Wiley, Gus Wilson, Rachel Langren, Dr. Hollenbeck, Danielle Roberts Long-time Hollenbeck lab member, Thomas Kelly Rainbolt (’10), graduated in May and moved to San Diego where he started graduate school in Chemical Biology at Scripps. Derek Danner (’12) picked up the synthesis of mannose derivatives where Kelly left off. Derek is planning to apply to medical school this spring. Rachel Landgren (’11) spent her third summer in the lab working on biochemical assays to monitor the binding of concanavalin A to glycosylated ankyrin repeat proteins. Rachel is planning to apply to medical school. Both Heena Pranav (’10) and Danielle Roberts (’12) joined the lab in 2010 and helped optimize the purification conditions for designed ankyrin repeat proteins. Heena is currently a research technician at UT Southwestern. Both she and Dani plan to apply to medical school. Colin Wiley (’11) worked with tryptophan-containing ankyrin repeat proteins and characterized their interaction with MV•Q8. He is planning to apply to medical school. Gus Wilson (’12) began work on a new project to investigate the flexibility of different repeats within the ankyrin repeat domain. He also plans to apply to medical school. 8 Hunsicker-Wang Research Group Nick Karagas, Cristina Hamme, Dr. Laura Hunsicker-Wang,, Porsha Shaw, Anika Schmander, Lindsey Handley, Abhishek Chhetri Lindsey Handley (’10) worked on the CuA protein from T. thermophilus, which is the target of the Sco protein from Thermus thermophilus, TtSco . Lindsey and Cristina Hamme, have shown that TtSco will attack CuA protein and form a mixeddisulfide intermediate. They identified that the TtSco C49S reacts the fastest and to the greatest extent with TtCuA C153S. Lindsey is attending graduate school at the University of California at San Diego. Porsha Shaw (’10) worked on studying the metal-binding properties of TtSco . She characterized the apo- and metal-bound forms of the protein using UV-Vis, CD, and EXAFS. She completed a thesis in the 2009-2010 year that encompassed her 3+ years of work. Porsha is attending graduate school at Duke. Kaitlin Elsenheimer (’10) worked on the chemical modification of the Rieske protein using diethylpyrocarbonate. Her work led to her being an author on our second mamuscript that was published in Biochemistry in summer 2010. Kaitlin is working in the biomedical industry and she ultimately plans on attending medical school. Emily Whitney (’10) has produced the L135E mutant of the Rieske protein, which will probe the effect of adding a negative charge adjacent to the cluster. She characterized the mutant using pH-dependent UV-Vis and circular dichrosim and EPR. She also crystallized the protein. Emily is attending pharmacy school at the University of Georgia. Cristina Hamme (’11) has been working on demonstrating that TtSco acts to reduce the disulfide bond of TtCuA through trapping the mixed-disulfide 9 intermediate formed during the proposed mechanism of disulfide bond reduction. She and Lindsey Handley have shown that TtSco will attack CuA protein and form a mixed-disulfide intermediate. She has also worked to understand which of the Sco cysteines is more reactive. She has also worked on probing the metal binding properties of TtSco and shown that it binds Cu2+ , Cd2+, Co2+ and Ni2+ with relative affinities of Cu2+ > Cd2+> Co2+ ~ Ni2+. She is completing an honors thesis this year. Cristina plans on attending medical school. Anika Schwander (’11) has continued her work on the Rieske protein. Anika has produced the L135R mutant of the Rieske protein, which is designed to raise the potential of the protein by adding a positive charge adjacent to the cluster. She has characterized the protein using pH-dependent UV-Visible and circular dichroism spectrscopies. She has also reacted the protein with diethyl pyrocarbonate, which only forms an adduct with a deprotonated histidine. She showed that this mutant behaves largely like the wild type protein. In addition, she has worked to characterize a 3 cysteine, 1 histidine MitoNEET-like mutant of our protein in order to probe the role of the protein scaffold in the stability of the [2Fe-2S] cluster. Anika plans on attending graduate school. Abhishek Chhetri (’12) has been working on the crystallography aspects of the Rieske project. He has been working on the refinement of L135A, L135E and Y158F crystal data. In addition, he has worked on the expression and purification of the G156S and G156T mutants of the protein. These mutants are designed to raise the potential of the clusters by adding an OH-S* hydrogen bond to the cluster. Abihishek plans on attending graduate school. Rishi Goswamy (’12) joined the lab last year and has been working on the role of the (NH4)2SO4 precipitation in the purification of the Rieske protein. He is establishing if the increase in yields obtained by removing the purification step are offset by changes in long-term stability of the protein. Nick Karagas (’13) joined the lab in the summer. He has been performing the chemical modification of the Rieske protein with DEPC. Nick worked to establish the differences in the reaction of DEPC with L135E and Y158F as compared to wild type and L135R. He showed the L135E has a markedly different reaction than any of the others with a considerably slower reduction of the cluster. Nick plans on attending graduate school. Nikita Mukhitov (’13) joined the lab in fall 2010. He is working on the CuA protein from Thermus thermophilus. He has learned how to purify it and the C149S and C153S mutants. He will be learning how to react the proteins with the Sco mutants. He will also be probing the metal binding properties of these mutants. Nick plans on attending graduate school. 10 Kelly-Zion/Pursell Research Group Sawan Vaidya, Tim Sowers, Jaskirat Batra and Daoqi Wang Dr. Chris Pursell and Dr. Peter Kelly-Zion Tim Sowers (2011, BS Engineering Science) and Daoqi Wang (2011, BS Engineering Science) worked together to develop an experimental technique to measure the concentration distribution of vapor above an evaporating liquid film. The technique uses computer tomography to deconvolute absorbance measurements taken with an FTIR. Jaskirat Batra (2012, BS Engineering Science) headed an investigation of the effects of the size of a sessile drop or film on its evaporation rate. The theoretical analysis of the evaporation of a small drop resting on a solid substrate in a quiescent environment has the non-intuitive result that the evaporation rate is proportional to the radius of the drop’s contact line, and not the surface area of the drop. Jaskirat investigated the range of applicability of this result, as well as how natural convection of the vapors may influence the evaporation rate. Sawan Vaidya (2010, BS Engineering Science) developed computer code to automate the analysis of shadowgraph videos of evaporating films. His code computes the film volume, surface area, thickness, and contact angle for each image frame in the video. The evaporation rate is computed from the change in volume from one image to the next. 11 Mills Research Group Drew Metzger, Remu Navaz Gangji, Cliff Woodford, Dr. Nancy Mills, Blair Shackleton, Isaac Zoch, Margaret Hilton, Vicky Cheng, Dr. Sean McClintock, Taylor Hoyt, Blake Tresca Blair Shackleton ('11) and Isaac Zoch ('12) worked on the synthesis of phenyl substituted bis-indenylidene dication precursors with phenyl spacers. In an amazing tour de force they were actually able to show spectra of dications for the undergraduate research symposium at the end of the summer. Isaac continued his research during the fall. We are particularly excited about this chemistry because Dr. Sean McClintock has discovered a superacid system for making the dications that gives very clean spectra, so we anticipate conversion of their precursors into dications before the summer research season. Blair is planning on graduate school in biomedical sciences when she graduates; Isaac is hoping to go to medical school. Taylor Hoyt ('12) led the team of Drew Metzger ('13) and Remu Navaz Gangji ('13) on our first venture into Suzuki coupling reactions. They were working on the preparation of bis-indenylidene dication precursors, but unlike Blair and Isaac, they were attaching the spacer in a different place. The advancements allowed by their very careful work will set the stage for our chemistry for several years. Taylor will work after graduation and then probably go to graduate school; Drew is thinking of graduate school and Remu of medical school. Blake Tresca ('10) finished his research on the reduction of substituted benzylidene dibenzocycloheptatrienes. We were hoping that the reduction would give antiaromatic dianions; instead the products were aromatic tetraanions. The dianions 12 were invisible in the NMR spectra of the reaction mixture, suggesting that they were particularly antiaromatic, with a very small HOMO/LUMO gap. The research has been submitted to the Journal of Organic Chemistry. After his December graduate, Blake is doing an internship in the chemical industry and planning on graduate school in chemistry. Margaret Hilton ('12) and Vicky Cheng ('13) followed on the steps of Blake's chemistry with the synthesis of precursors to antiaromatic dianions that contain one fewer benzannulated rings than did Blake's or a different arrangement of two benzene rings. We are anticipating that this difference in benzannulation might allow us to form antiaromatic dianions visible by NMR spectroscopy. Margaret is planning on graduate school in chemistry; Vicky, who has continued her research for both semesters of the academic year, is also considering graduate school. Finishing up the dianion group, Cliff Woodford ('11) attempted the formation of an antiaromatic dianion through a photochemical deprotonation of the heterocyclic dixanthane species. He obtained instead the tetraanion from deprotonation next to the two oxygens of the dixanthane. This paper, along with the report of the dianion of dixanthylene by reduction with sodium by Mary Black (Catawba College, '09) is under (minor) revision for the Journal of Organic Chemistry. 13 Urbach Research Group Erik Skoglund, Faizan Zubair, Dr. Vijay Ramalingam, Dr. Adam Urbach Marlies Hager Peggy Guo (2012) completed the initial characterization of a new fluorescencebased chemical sensor this spring. The paper was published this fall in Chem. Eur. J. Peggy is part of the McNair program and plans to pursue an MD upon graduation. Marlies Hager (2011) continued working this spring and summer on developing methodology for characterizing extremely stable DNA complexes. Marlies plans to pursue a PhD in chemistry. Erik Skoglund (2011) worked in the spring and summer to characterize the stability of a modified model collagen complex. Erik plans to pursue advanced studies in pharmacy. Faizan Zubair (2011) worked in the summer to characterize a series of fluorescent compounds in complex with cucurbit[n]urils. Faizan plans to go to graduate school in chemical engineering. 14 2010 SUMMER UNDERGRADUATE RESEARCHERS IN CHEMISTRY 1st row: Dr. Adam Urbach, Dr. Bert Chandler, Dr. Nancy Mills, Vicky Cheng, Kendall Bailey, Drew Metzger, Remu Navaz Gangji, Gus Wilson 2nd row: Taylor Hoyt, Dr. Michelle Bushey, Dr. Laura Hunsicker-Wang, Tim Ward, Cliff Woodford, Blair Shackleton, Chris Schardon, Zoe LaPier, Daren Danner 3rd row: Blake Tresca, Michael Dzerlenga, Dr. Sean McClintock, Anika Schwander, Abhishek Chhetri, Porsha Shaw, Isaac Zoch, Margret Hilton, Nick Karagas, PJ Pritzker, David Shope, Michael Cammarata, Faizan Zubair, Danielle Roberts, Dr. Chris Pursell. Last Row: Mariles Hager, Erik Skoglund, Tim Sowers, Daoqi Wang, Dr. Vijay Ramalingam, Dr. Shane Kendall, Sawan Vaidya, Maduka Ogba, Dr. Steven Bachrach, Dr. Peter Kelly-Zion, Dr. Jessica Hollenbeck, 15 STUDENT RESEARCH PRESENTATIONS, Undergraduates indicated by asterisks Pittcon 2010 Orlando, Feb. 28- Mar. 5, 2010 Michael B. Cammarata*, Jonathan M. King, Michelle M. Bushey, “Exploring the Phosphorylation Sites of the ZU-5 Domain of the Tight Junction Protein ZO-1 Through Capillary Electrophoresis” 239th National American Chemical Society Meeting, San Francisco, CA, March 21-25, 2010 David Stuck* and Steven M. Bachrach, “Theoretical studies of [n]cycloparaphenylene,” Michael Dzierlenga* and Steven M. Bachrach, “Microsolvation of Uracil,” Cecily C. Wilbanks* and Steven M. Bachrach, “Superbases: Substituted Pyridines and Quinuclidines,” Kaitlin N. Elsenheimer*, Mary E. Konkle, and Laura M. Hunsicker-Wang, “Chemical Modification of the Rieske Protein Using Diethyl Pyrocarbonate (DEPC)” Lindsey Handley*, Cristina Hamme*, and Laura M. Hunsicker-Wang, “Purification of TtCuA and the Characterization of Protein Interactions between TtCuA and TtSco” Porsha Shaw* and Laura M. Hunsicker-Wang, “Metal Binding Characterization of TtSco” Emily Whitney* and Laura M. Hunsicker-Wang, “L135E Mutation to the Rieske Protein of Thermus thermophilus” Blakely Tresca* and Nancy Mills, “Attempted preparation of antiaromatic dianions from reduction of 5-benzylidene-5H-dibenzo[4.5]cycloheptene: Unexpected overreduction to the tetraanion” Nicholas D. Hargreaves*, Jordan M. Chinai, and Adam R. Urbach, "Crystal Structure of an Insulin•Cucurbit[7]uril Complex" Marlies V. Hager*, Vijayakumar Ramalingam, and Adam R. Urbach, "Finding an Optimal Platform for Studying Oligovalent Binding" Bi Y. Guo*, Jacob W. Reynolds*, and Adam R. Urbach, "Co-Hosts for Peptide Recognition by Cucurbit[8]uril" 239th National American Chemical Society Meeting, Boston, MA, Aug. 22-26, 2010. Christopher L. Schardon*, Kyle Meinhardt, James R. Shinkle, Michelle M. Bushey, “Probing UV-signaling pathways in plants: Identification of UV Absorbing Species in Arabidopsis Thaliana and Cucumber Seedlings" 16 2010 CHEMISTRY DEPARTMENT AWARDS Achievement in Organic Chemistry Jake Reynolds American Institute of Chemists Award Christopher Schardon Award for Academic Excellence and Research in Chemistry Lindsay Handley and Jordan Chinai CRC Freshman Achievement Award Patricia Lenihan, and Andrew Metzger John A. Burke Award in Inorganic Chemistry Jake Reynolds Junior Achievement Award Michael Dzierlenga and Marlies Hager McGavock Award for Outstanding Research David Stück McGavock Poster Award Christopher Schardon 2010 McGavock Scholarship Margret Hilton Merck Senior Achievement Award Emily Whitney Outstanding Student Assistant Award Brant Konetchy Senior Service Award David Stück and Jordan Chinai Senior Achievement Award in Research Porsha Shaw and Derek Smith Undergraduate Award in Analytical Chemistry Marlies Hager 2010 McGavock Award Winner Ina Beth McGavock Scholarship Recipient William Crews McGavock Scholarship Recipient David Stück Margaret Hilton 10-12 Marlies Hager 09-11 17 CHEMISTRY CLUB Chemistry Club Officers 2010-11 Colin Wiley, standing in for Vicky Cheng, Marlies Hager, Garry Winkler Leigh Anna Logsdon, Florisa Lubrin, Michael Rodriguez, Yemi Idowu, Lauren Holguin, Cliff Woodford President: Marlies Hager Secretary: Florisa Lubrin Webmaster: Vicky Cheng VP Outreach: Leigh Anna Logsdon VP on Campus Events: Cliff Woodford VP Socials: Michael Rodriguez VP Green Chemistry: Lauren Holguin Treasure: Garry Winkler Mentoring: Yemi Idowu This year, the chemistry club remained focused on serving both the Trinity and San Antonio communities. The battery recycling program on campus, as well as demonstrations at the Children’s Museum and Trinity Science Academy to help get kids excited about science as a young age, were among our main focuses this year. We also celebrated Mole Day by selling "Trinity Element" t-shirts and had a great on-campus Mole Day demonstration that was attended by well over 100 students! In April, we will be honoring Marie Curie at our annual spring Scientist Day demonstration. Finally, we are trying to provide a series of lectures regarding alternate careers in chemistry, and toward that end, we hosted Trinity professor Jeffrey Nordine for a lecture on teaching science in grades K-12. 18 REPORT FROM THE FACULTY AND STAFF Steven Bachrach In the spring semester I taught CHEM 1300, our introduction to chemistry course. This was an interesting experience, teaching a class to students with poor backgrounds in chemistry. In the fall I was on leave. I visit five different universities (Georgia, Virginia Commonwealth, North Texas, Texas Tech, and Texas A&M) each for about a week. I initiated collaborations with Fritz Schaefer at Georgia and Bill Hase at Texas Tech. I learned to do some molecular dynamics with Dan Singleton and had great conversation with all my hosts. It was nice to get away from administrative duties for the semester, and Bert Chandler admirably covered those duties during my absence. Carmen maintained her executive platinum status on American Airlines thanks to a very busy schedule that included a trip to Barcelona. Dustin will graduate from Rice in May 2011 and then begin a career at Microsoft. Carmen and I vacationed with Dustin in Yellowstone and the Grand Tetons in August – a truly wonderful location. Over winter break, Carmen and I spent a few days in Santa Fe. I hear from former students every so often – including some impending nuptials. I would love to hear from any of you! Michelle Bushey In the spring semester I was on academic leave. It was wonderful. In the fall I taught Analytical Chemistry, CHEM 3432, and Chemistry for the Studio Artist, CHEM 2305. Both classes saw some changes. The recently funded NSF-CCLI grant allowed us to purchase a handheld XRF and ICP-OES. Purchase and training on the XRF happened at the end of the spring semester and the installation and training on the ICP occurred near the start of the fall semester. The ICP was used in place of the atomic absorption spectophotometer for the soil analysis lab in 3432. The XRF was used in 3432 to analyze a variety of samples, some student supplied, and a some at the San Antonio Museum of Art. The CHEM 2305 students used the XRF at the McNay museum to examine several paintings from different time periods and they also used it a local conservator’s studio to examing a 17th centuryTibetan Thangka. These two instruments are being integrated into several classes in Chemistry, Geosciences, and Biology. Stay tuned. I attended Pittcon again, this time in Orlando. I also attended the CUR business meeting and conference in Ogden Utah in June. Kate Ritson traveled to the meeting 19 too and together we presented a poster on the combination of chemistry and art. Much fun. Academic leave in the spring minimized my service activities but they picked up again in the fall. They included serving on the Advising and Registration committee, and an administrator review committee. I continue to coordinate the FAST Grant program. The ‘Instrumentation Topics for the Teaching Laboratory’ column, published in the Journal of Chemical Education, had a strong first year with 10 articles published. Fingers are crossed that the first six months of 2011 are spoken for. Research activities included work on the collaborative project with Jim Shinkle on the identification of flavonoids and sinapates in cucumber and Arabidopsis. Work on the diffusion of analytes on porous polymer monoliths used in capillary electrochromatography was stepped up and will be supported by the Petroleum Research Fund beginning in March of 2011. This will become the major focus of the lab for the next few years. Erin is in the midst of applying to colleges; Sean is in the middle of his first year of high school and anxiously awaiting the spring baseball tryouts. Dennis is still in the Biology department but now, until the building is gutted, has a window in his office. Lucy and Trixie actually play with each other sometimes – until someone goes to far. Watching the cross-species interactions is quite interesting. Better pots are thrown now, and occasionally sold. Summer vacation was on the west coast, visiting San Francisco, Oregon, and Portland. Bert Chandler 2010 passed way, way too quickly. It started with the end of an era. I taught Inorganic Chemistry to the sophomores for the 9th and last time (since we’ve moved Biochemistry into the 4th semester, Inorganic will not be taught to Juniors … with a PChem prerequisite). The class went well, but I’m looking forward to the much smaller classes and experimenting with different things in both the course and lab in the future. The fall brought a new challenge as Dr. Bachrach went on sabbatical and left me in charge of the shop. As you might expect, I worked to find the right balance between ruling with an iron fist and gently employing personal inducements in my role as benevolent dictator. My success in doing so can probably be gauged by the fact that I am no longer Chair, and that Steve has been left to pick up the pieces. The rumor floating around Northrup Hall is that Steve returned with a signed letter claiming that if should ever become incapacitated and no longer able to fulfill the duties of his office, his powers should be transferred to, in order: Nancy Mills, Michelle Bushey, Chris Pursell, Adam Urbach, Laura Hunsicker-Wang, Jessica Hollenbeck, Gloria Castoreno, Noel Burns, Terry 20 Gonzalez, Johnny the Janitor, Sarah Palin, and Bert Chandler. I remain unsure as to how I should feel about this. In all seriousness, I very much appreciate the support that everyone in the department showed during the dark time last Fall, especially Steve who was always willing to answer my questions while he was on leave. I was somehow able to do a little traveling this year, and was especially successful in pairing work travel for meetings/conferences with visits to friends (i.e. was able to stick a grant or the department with the airfare bill). Unfortunately, I was also stuck in DC at my parents’ house with no electricity or heat for 3 days, when 31” of snow was dropped the day after an NSF panel. Dutiful son that I am (who also needed to get to the airport), I shoveled the driveway (4 times in 24 hours, actually) and reminded myself of why I live in Texas. I somehow managed to be chosen for a week-long “Green Chemistry Tour” of Germany, sponsored by the German government – my far my largest success in pairing work travel with fun. The Germans kept us scheduled from 8am – 10 pm pretty much every day, but they were wonderfully gracious hosts and they paid for everything but the flight over. We visited several research centers and Universities within ca. 100 miles of Frankfurt, and met with dozens of people from academia, industry, and their funding agencies. It really was a great experience, I learned a ton, and am looking forward to going back! I heard from a number of former group members this year, including Christina Crump, Natalie Hoover, Lindsey Beakley, Bethany Auten, Brittany Scruggs, Suzi Kilgore, Rachel Korkosz, Graham Mullings, and Heather Hartshorn. It’s always great to hear from students who have managed to make something of themselves in spite of my best efforts, and I’m proud of all of your accomplishments. If I don’t have your name listed, let me know about it and I’ll fix it for next year. Shameless ploy for email? Probably so, but I would love to hear how everyone is doing. 21 Jessica Hollenbeck If I had a dollar for every time my six-year old son said “That’s boring!”, I’d be rich. If I had a quarter for every time my almost two-year old daughter said “No!”, I’d be even richer, but if I had a nickel for every time I walked back and forth between my research laboratory in CLS and my office in MEB in 2010, I could retire today! And while it’s true that the number of times I walked back and forth may not be significantly different from years past, the distance more than doubled in 2010 due to the start of construction of the new science facility. Needless to say, I’m very excited about moving into the new building in December. 2010 started with a busy semester. I taught Biochemistry I for the first time in three years to 42 students! It was a lot of fun, but also, a lot of grading. That trend continued in the Fall, when I taught the second-semester of Organic Chemistry to 44 students. In the Fall, I also taught Biochem Lab… a course that has evolved quite a bit since I arrived at Trinity in 2006. This year I added three new experiments including one that monitored the thermal denaturation of designed ankyrin repeat proteins as a function of pH and ionic strength. My research group continued to explore the potential for ankyrin repeat proteins to act as multivalent ligand scaffolds. There were six of us in the lab over the summer: Rachel Landgren returned for a third year; Colin Wiley for his second, and three new students, Derek Danner, Danielle Roberts, and Gus Wilson joined the group. Our group picture shows the six of us standing in the cold room adjacent to my lab in CLS. In Colin’s opinion, the cold room was a blessing. I often found him cooling off in there after walking to lab from lower campus in the brutal heat and humidity we endured in June and July. I think Rachel, Dani, and Gus would disagree. Each of them lost significant amounts of protein when the thermostat inside the cold room failed on two separate occasions… once in June and once in July. Hopefully, the cold room in the new building will be more reliable. In the meantime, we’re doing dialysis of precious samples in the deli case in the lab next door. Unfortunately, the deli case isn’t big enough for Colin… Laura Hunsicker-Wang In Spring 2010, I taught one section of CHEM 3221 (Inorganic Lab) and a new special topics class “Structural Biology”, team taught with Adam Urbach. I really enjoyed teaching this new class, as it was the first special topics class that I have taught. In fall 2010, I taught two sections of CHEM 1118 (general chemistry lab) and one section of CHEM 1318 (general chemistry). I enjoyed teaching these new, enthusiastic students in chemistry. 22 In terms of research, we published our second paper this year. It was a report on the reaction of diethyl pyrocarbonate (DEPC) with both the wild type Rieske protein and a mutant that removed all but the ligating histidines in the protein. We showed that the DEPC will form an adduct on the ligating histidine 154 and lysines in the large domain. Along with modification, the protein also becomes reduced, presumably due to the change in the potential upon modification. It was published in the summer in Biochemistry. The Sco project has also progressed nicely. We have shown that the Thermus thermophilus Sco protein will bind Cu2+, Cd2+, Ni2+, and Co2+. We have also done competition experiments to show the relative affinities of these metals. In addition, we have been probing the disulfide bond reduction activity of Sco by reacting mutants of both Sco and CuA that remove a cysteine. We have shown that the Sco C49S and CuA C153S mutants will react to form a mixed disulfide intermediate, which is very good evidence for the disulfide bond reduction activity of Sco. We aim to write up the results of the work this year. On a personal note, my daughter, Lilian, will be 4 this year. She is just the light of my world and so smart and funny. She is easily the funniest person I know. My husband is wonderful and we are very happy, having celebrated our 10th wedding anniversary this year. He continues to work at USAA as a financial advisor and has been promoted into the wealth management division. Joseph B. Lambert I arrived at Trinity in the middle of the fall semester, having retired after 45 years on the faculty of Northwestern University in Evanston, Illinois. This is very familiar territory to me, as I grew up in San Antonio and went to Alamo Heights High School, very close to Trinity. Although I will not be teaching courses, I will give occasional lectures and am starting a research group. My overall areas of research are physical organic and archaeological chemistry, with specialization in organosilicon chemistry and nuclear magnetic resonance spectroscopy. I will begin research at Trinity with studies of ancient amber, an organic material used for jewelry and derived from fossilized plant resins. The research is heavy on NMR with overtones of botanical gardens and museums. Nancy Mills It was a very interesting, busy, and challenging year. The changes in our curriculum, particularly the implementation of an introductory chemistry course for students with weaker chemistry background resulted in a bumper crop of students for the first semester of organic chemistry, ~130 students, and I was fortunate to be able to teach all of them, luckily in two sections of the course. I continued to teach my Chemistry of Crime course for non-science majors. I created a number of active learning modules (POGIL, Process Oriented Guided Inquiry Learning) to 23 help make the learning of chemistry a bit less traumatic for these students who have avoided a science course at Trinity for nearly four year. Every year at least one student complains on the course evaluation that there is too much chemistry in the course! It is great fun and the students write wonderful term papers. The summer research group was amazing, as always. It seemed to be the most productive, as evidenced by two papers submitted from the summer's work. I had a great group of 9 undergraduates who were superbly mentored by Dr. Sean McClintock. I had met Dr. McClintock while I was on leave at the University of Oregon and I was absolutely delighted when he decided to do a post doc with me. His assistance was invaluable during the installation of our new 500 MHz NMR spectrometer, with funding from the Major Research Instrumentation program of the National Science Foundation, and some help from stimulus funds. We were able to join my family for a trip to West Virginia where my niece Sara is a climbing guide. She is so good that I actually did a multi-pitch climb, as well as some pretty exciting rafting. The culmination of the summer was a weeklong backpack in southern Colorado with some college friends. We have discovered ultra-light backpacking, and now sleep in hammocks rather than tents. Not sleeping on the group has really enhanced my enjoyment of the out-of-doors. The daily rain got a little old, but all in all, it was a wonderful trip. The fall was much, much busier than I had envisioned. I was elected to the Commission on Promotion and Tenure because I realized if I didn't serve my threeyear term, I might run out of the opportunity to do so. However, when I agreed to stand for election, I didn't realize that I would also be asked to serve as one of the chairs of the newly constituted Strategic Planning Committee, along with the Chair of the Board of Trustees and the Vice President of Academic Affairs. I gave myself a crash course in strategic planning by reading as widely as I could. The chance to help shape the course of the university for the next decade was really exciting, as was the opportunity to engage in conversations with folks from all areas of campus. I will continue to serve as chair of the committee probably for another year or so. It is a really exciting time to be at Trinity. With all of this activity, I must have panicked about research because I submitted two papers in September, that were published by the end of the year and wrote two more in the fall, as detailed in the report of my students activities. It was really fun to see all the research come together. On other fronts, I am serving my last year on the Committee on Professional Training of the American Chemical Society, for a decade of service, and will serve on the Advisory Board of the Petroleum Research Fund of the ACS, starting in May. PRF is the primary granting agency of the ACS and I am looking forward to learning a lot. My daughter Carrie and her husband Thomas (her grade school boyfriend) live in St. Louis where she works for a biotech start-up company and Thomas is involved in a cloud computing group, which was recently purchased by Rackspace, headquartered in San Antonio. Will is a senior at Grinnell College and his major in political science is as close to science as he wanted to get. My husband Mark took a position 24 as a physician for refugees who are required to get medical examinations shortly after they enter the country. The stories of some of these folks are truly amazing. Chris Pursell Once again, I am at a lost trying to remember what happened last year. During the spring semester, I taught physical chemistry lecture (quantum and spectroscopy) and the physical chemistry laboratory. All went well and we even learned some chemistry! During the summer I helped supervise research students on the two joint projects I have been pursuing for the last few years. Working with Professor Chandler, we have been studying the chemical and physical properties of supported gold nanoparticle catalysts. In my lab we have focused on quantifying the adsorption of CO using infrared spectroscopy. In particular, we have been developing a Temkin model for determining the thermodynamics (enthalpy and entropy) for the adsorption process. Working with Professor KellyZion (engineering science), we have continued to examine the evaporation of thin hydrocarbon films, testing the influence of geometry, and trying to discern the importance of gas-phase diffusion and buoyancy-induced convection. For the fall semester, I have been on academic sabbatical, performing research at the University of Torino. This has involved a collaborative project with Professor Boccuzzi and her research group. The research area again concerns gold nanoparticle catalysts and measuring their physical and chemical properties. Much of the advancements regarding the Temkin model has been accomplished while in Italy. I have also made additional contacts with Professor Della Pina (University of Milano) and Professor Pinna (University of Venezia). I am hopeful that these contacts will also lead to fruitful collaborations in the future. On the more personal side, we have really enjoyed our time in Italy. It is a fantastic place with many beautiful cities. Over the Christmas – New Year’s break, we visited Roma and Firenza with our older kids (Janet (25) and Timothy (22)), along with Timothy’s new wife (Kristine). It was a great family holiday. We (Kathy, Jacob (16) and I) have been trying to learn some Italian, but it has been slow going. We are able to get around and communicate enough to get by. I would love the time to really study the language, but there are only so many hours in each day! While in Italy, we have also made many good friends at the English-speaking International Church of Torino. The church is half African and half everything else. We have really enjoyed the church family and being a part of this very unique Christian church. I will finish the Italian sabbatical report in the next Annual Report. So, stay tuned! 25 Adam Urbach The balancing act that is life continues to challenge, motivate, occasionally excite and disappoint, mostly satisfy, and generally move along day-by-day. My teaching duties were routine in the fall with organic lecture and lab, and new and unusual in the spring with a newly developed Advanced Interdisciplinary Topics course (Structural Biology) offered in a great collaboration with Laura Hunsicker-Wang, and a newly developed Advanced Analytical Methods class taught to a lively and engaged group of seniors while Michelle Bushey was on academic leave. My research program, funded by NSF, Welch, and Dreyfus grants, continues to explore the interactions of synthetic organic compounds with biomolecular targets, including peptides, proteins, and DNA. The increasing complexity in biomolecular targets, designed molecules, and assays provides a welcomed challenge that should yield greater insight into biomolecular recognition and, ultimately, useful devices for sensing and separations. Participating in numerous scientific meetings and university visits this year I was inspired and invigorated by the creative and rigorous work that is moving forward the fields of physical-organic, bio-organic, supramolecular, nano, and materials chemistry. I look forward to my imminent academic leave in David Tirrell's group at Caltech. This year I completed six years as faculty advisor to our ACS Student Affiliates chapter and left the organization in the capable hands of Jessica Hollenbeck, I enjoyed organizing the 2010-11 department seminar program, and I began training in the very interesting role of Faculty Advisor to the University Honor Council. My family also looks forward to the move to California. Sebastian is 4 and enjoying Montessori school, soccer, and frequent camping trips in the Texas hill country. It's fun to balance. Marilyn Wooten It is with pleasure that I continued my teaching activities with the Chemistry Department. In the spring During the Spring 2010, teaching two sections of Organic Chemistry 1 lab (CHEM 2119) and Basic Chemistry 1300 (CHEM 1300) was a worthwhile challenge as I finished writing my dissertation. In the Fall, I taught two sections of the General Chemistry Laboratory (CHEM 1118). Training on the new Varian ICP-OE (Inductively coupled Plasma Optical Emission Spectroscopy) and the X-ray fluorescence analyzer was accomplished so that these exciting techniques may be included in the first year chemistry laboratory experience. In fact, with Noel Burns’ help we incorporated the new ICP-OES during the laboratory course for CHEM 1118. Teaching General Chemistry (CHEM 1318) was much more comfortable this time around as my dissertation was completed. I learned more about teaching in working with Dr. Hunsicker-Wang and Dr. Kuhler. I had fun managing the chemistry department’s role in working with seventh graders for the Trinity Science Academy, a Howard Hughes Medical Institute 26 funded program that facilitates the exposure of students, from under-resourced school districts, to science in a university environment. The middle school students came each Friday for a month and participated in hands on scientific activities that connected the scientific method with everyday products. In the process, students found out that claims made by the companies that manufacture these products were not always what they seemed. We even tweaked the sunscreen experiment to better measure how well each sunscreen performed. In addition to teaching, I graduated, earning my Ph. D. form University of Texas at San Antonio, in Spring 2010 and published two papers with Dr. Gorski, my advisor. It’s been a wonderful change to finally finish. We are still working on a couple more papers. I also taught part-time in the summer at UTSA. On a personal level, I enjoy mountain biking and took up road biking over the summer. I have 3 sons (Joe, Ben, and Bill), a husband, and a dog who keep me quite busy away from Trinity. PART-TIME FACUTY AND POST DOCTORAL ASSOCIATES Dr. Mary Konkle finished her time at Trinity in May 2010. She is now a tenure-track faculty member in the chemistry department at Eastern Illinois University. In her work at Trinity, Mary developed methods to chemically modify the Rieske protein. She modified the protein with diethylpyrocarbonate, which specifically reacts with deprotonated histidines. We used this reaction to probe the reactivity of histidine ligands of the [2Fe-2S] cluster. Her work resulted in a publication in Biochemistry in July 2010. Dr. Frank Walmsley continued his long-term association with the department by teaching a section of CHEM 2119 in the Spring. He continues to review for the Journal of Chemical Education and is continuing work on this series of Resources for Chemistry Teachers. Dr. Radhika Nair worked on nanoparticle and catalyst synthesis in Dr. Chandler's lab. 27 Dr. Shane Kendell joined the Chandler group from the University of New South Whales, Australia . He worked on understanding halide poisoning of Au/TiO2 catalysts Dr. Sean McClintock joined the Mills group in January 2010 and has rapidly made himself indispensible. He received his PhD from the University of Oregon, working in the group of Dr. Michael Haley, which was also the group in which Dr. Mills spent her sabbatical in 2008-09. Dr. McClintock was responsible for introducing the Mills group to the world of coupling reactions which has revolutionized our approach to the synthesis of precursors to antiaromatic dications. He developed a new superacid which promises to be much more effective than the most commonly used superacid, Magic Acid. His work has resulted in one paper in print and another submitted at this writing. He was the point person on the installation of the new 500 MHz NMR spectrometer in spring 2010 and wrote instruction sheets for the use of it and the new software for our 300 MHz NMR spectrometer. He is planning on a career at an undergraduate institution and at this writing, has one job offer in hand. We will miss him tremendously. Dr. Vijay Ramalingam Dr. Vijayakumar Ramalingam joined Dr. Urbach's research group upon finishing his PhD at City University of New York. Dr. Ramalingam taught General Chemistry Laboratory in the spring and is working with Dr. Urbach on novel supramolecular constructs for the purpose of protein separations, and on the synthesis of DNA-binding small molecules 28 EMERITUS FACULTY Bill Kurtin (and Sandra Kurtin) Dr. Bill Kurtin fully retired in 2006. In 2007, after doing some consulting on the chemistry of essential oils for a friend who is an aromatherapist, he developed a presentation on the biochemistry of olfaction. He now gives guest lectures on the subject in a class titled Brain and Behavior each fall and spring at the University of the Incarnate Word. He continues to take a class studying the Czech language, and he was able to use the language when he and wife Sandra spent a month in the Czech Republic and Poland in summer 2010. On the less academic side, he continues his interest in music activities, joining the University Presbyterian Church choir, and leading the Medina Mud Band, which still plays several events each year. He and Sandra have spent much time since retirement making improvements to the land and buildings on their property in Junction, TX. They also enjoy spending time with their children and grandchildren, the latter now numbering 6, with one more on the way. In 2008 they moved back to San Antonio from Bulverde. They miss the large vegetable garden they had, but do not miss mowing the big yard. Ben Plummer Ben and Gail Plummer are still active in retirement. When time permits, they drive to Austin to watch their twin 10-year-old grandsons, Alex and John, play little league baseball. And they try to keep up with their 14 year old Grandson, Adam, who is very busy in a magnet high school and cross-country racing. They continue to travel overseas and enjoy touring with a friend who coordinates small group tours. This spring they traveled with their son Scott, the veterinarian neurosurgeon, to South Africa and Zimbabwe. The beauty and climate of Capetown were a surprise. Krueger National Park offered opportunity for overnight tented camping and close viewing of elephants, zebras, giraffe, lion, cheetah, leopard, hippos, and rhinos from the safety of a Land Rover. On March 26 they hosted their 50-year wedding anniversary dinner party at Ben’s Golf Club for 55 people that included family and friends. Ben presented a brief slide show with appropriate audio music. Scott, Doug, Suzanne, and Jeffrey presented a brief drama about their lives with their parents. Ben and Gail are eagerly anticipating a cruise up the Rhine River from Vienna to Amsterdam in June. They join two other couples they met when Ben was a grant officer at the National Science Foundation in 1994-95. An Ohio State couple, close friends from grad school days, will also join the cruise. Ben and John Burke regularly play golf at Olympia Hills Golf course where both have a year round membership. Gail and Ben share season tickets to Spurs games and anticipate attending some playoff games this April. They enjoy their new house and swimming pool and look forward to a bountiful crop from their backyard garden. 29 Ben would enjoy receiving emails from former students to learn about their current activities. bplummer1@satx.rr.com. Gail and Ben Riding Camels on their Egyptian Tour March 2006 30 CHEMISTRY STAFF Noel Burns Lab/Stockroom Manager This year has been busy continuing to make the Chemistry Labs and Stockroom more productive than ever. The First Year and Sophomore courses this year were very smooth running with integration of new technology such as our new Varian ICP/OES. I have also been participating in the new building design process, assisting in the stockrooms and teaching lab areas. As we transition into the new building (Winter 2011), we are already planning emphasis of cross-departmental cooperation and consolidation of some stockroom storage areas and functions. We see this as a way to increase efficiency, reducing stock redundancies, lower expenses for the university. We are also excited about working more closely with other departments on research projects as well as teaching experiences. We are also coming out of a successful EPA Audit with confirmation that we are running quality labs and safe protocols, despite the Moody Engineering Building nearing the end of its usage. I have also maintained my participation in the National Association of Scientific Material Manager. This organization has been a great resource for me to lower costs, gather information, and get additional training to benefit the Chemistry Dept. Overall, this has been a great year for me and the department, and I am excited to see where we are next year. Gloria Castoreno continues to be the department secretary along with Terry. In 2010 has been watching all the construction next to the building MEB. SLH was torn down in Aug. 2010. Construction between buildings MEB and CLS has gone from a big hole to skeleton buildings. Home life is great, will travel any chance she gets. Taking on 2 new endeavors, church treasurer 3 year position and putting together a women church retreat for spring 11. Teresa Gonzalez is the secretary for the department. She is blessed with two adorable children ages 8 (daughter) and 9 (son). Ms. Gonzalez is selling her Caravan and downsizing to a compact car. She’s grateful for the opportunity to be a member of the Trinity family. 31 GRANTS FOR EDUCATION AND RESEARCH Welch Department Research Grant, 2009-2012, $150,000, Steven Bachrach, PI. “MRI: Acquisition of a Circular Dichroism Spectropolarimeter with Stopped-Flow Detection for Undergraduate Research” funded at $108,620 by the National Science Foundatdion, PI, Adam Urbach; Co-PIs, Bert Chandler, Frank Healy, Jessica Hollenbeck, Laura Hunsicker-Wang, 8/1/2007-7/31/2010 "MRI-R2: Acquisition of a 500 MHz NMR spectrometer by Trinity University", funded at $498,500 by the National Science Foundation-Major Research Instrumentation program, Nancy Mills, PI, Co-PIs Jessica Hollenbeck, Laura Hunsicker-Wang, and Adam Urbach, 1/1/10-3/31/11 National Science Foundation, CCLI, DUE-0942940. "Breadth and Depth in Elemental Analysis". CoPIs Benjamin Surpless and Candace Coyle. $200,000 (5/1/2010- 4/30/2013). National Science Foundation Scholarships in Science, Technology, Engineering, and Mathematics (S-STEM), DUE-0806471. "Financial Aid for Science and Technology Students. (Fast Student Grant Program)" PI, Michelle Bushey, CoPIs Wilson Terrell, Dennis Ugolini; $600,000. 7/15/2008- 2/15/2013. FACULTY RESEARCH GRANTS Steven Bachrach Trinity University Academic Leave, "Methods of Quantum Chemical Computations", Steve Bachrach, Fall, 2010 Michelle Bushey Petroleum Research Fund, "Fundamental Studies of Diffusion and Retention on Porous Polymer Monolith Stationary Phases used in Capillary Electrochromatography". $65,000 (3/1/2011- 8/31/2014)Trinity University Academic Leave, “Developing and Adapting Analytical Tools for the Analysis of Biological Samples of Interest.” Michelle Bushey, Spring 2010. Bert Chandler National Science Foundation CAREER Award “Chemical and Catalytic Characterization of Dendrimer Templated Bimetallic Nanoparticles” ($415,000) Award Period: 6/05-5/10. Camille & Henry Dreyfus Foundation Henry Dreyfus Teacher-Scholar Award ($60,000) Award Period: 1/08-12/12. 32 National Science Foundation “RUI: Preparation and Characterization of Dendrimer Templated Au-M Nanoparticles and Catalysts” ($ 280,000) Award Period: 9/108/13. Jessica Hollenbeck Camille & Henry Dreyfus Faculty Start-up Award. “Losing the Groove: Toward a Linear Scaffold of Ankyrin Repeats”. 2006-2011, $30,000. Research Corporation Cottrell College Science Award. “Designed Ankyrin Repeats as Scaffolds for Multivalent Recognition”. 2009-2011, $40,000. Laura Hunsicker-Wang Research Corporations: “Copper Chaperones from Thermus thermophilus: Structural and Functional Studies of TtSco”, $37,052, (2009-2010). Nancy Mills National Science Foundation –Research at Undergraduate Institutions "Antiaromatic Hydrocarbon Dications and Hydrocarbon/Heterocylic Dianions: The Relationship Delocalization and Antiaromaticity," $249,784 (2010-2013) National Science Foundation –Research at Undergraduate Institutions, CHE0553589, “The Role of Bond Localization in Antiaromaticity: Aromaticity/Antiaromaticity Continuum for Indenyl Systems”, $207,600 (20062010). Welch Foundation, “Understanding Aromaticity through the Prism of Antiaromaticity; Antiaromatic Dianions and Dications”, $150,000 (2007-2011) Chris Pursell Petroleum Research Fund – Type B Grant: “Experimental Study of Transport Phenomena of Evaporating Fuel Films”, $65,000, with Peter L. Kelly-Zion (20092012). Adam Urbach Henry Dreyfus Teacher Scholar Award, "Rigid Receptors for Multivalent Peptide Recognition" $60,000, (2009-2014) Welch Foundation, “Repeat DNA as a Multivalent Receptor” $150,000, (2009-2012) National Science Foundation, “CAREER: Synthetic Co-Hosts for SequenceSpecific Recognition and Labeling of Peptides in Aqueous Solution” $594,000, 2008-2012) 33 FACULTY PUBLICATIONS “Using the Pyridine and Quinuclidine Scaffolds for Superbases: A DFT Study," Steven M. Bachrach and Cecily C. Wilbanks,* Journal of Organic Chemistry 2010, 75, 2651–2660, DOI: 10.1021/jo100295s. “Computational Organic Chemistry,” Steven M. Bachrach, Annual Reports of the Progress in Chemistry, Section B: Organic Chemistry, 2010, 106, 407-427. “DFT Study of Cycloparaphenylenes and Heteroatom-Substituted Nanohoops,” Steven M. Bachrach and David Stück,* Journal of Organic Chemistry, 2010, 75, 6595–6604. “Peak parking determination of the obstruction factor in lauryl acrylate monolithic CEC columns”, Gwen J. Anderson, Zoe LaPier*, Michael B. Cammarata*, Tae Sun Cullum*, and Michelle M. Bushey, Electrophoresis, 2010, 31, 1583-1585. “Introduction to a New Column: Instrumentation Topics for the Teaching Laboratory”, Michelle M. Bushey, Journal of Chemical Education, 2010, 87, 8-9. “Improving Oxygen Activation Over Supported Au Catalysts Through the Controlled Preparation of Bimetallic Ni-Au Nanoparticles”, Bert Chandler, C. Long, John Gilbertson, G. Vijayaraghavan, Keith Stevenson, Chris Pursell, Journal of Physical Chemistry C, 2010 114, 11498-11508. “Ultrafast Optical Study of Small Gold Monolayer Protected Clusters: A Closer Look at Emission” Sung Hei Yau, Oleg Varnavski, John D. Gilbertson, Bert D. Chandler, Guda Ramakrishna,|and Theodore Goodson III, The Journal of Physical Chemistry C, 2010, 114, 15979-15985. “Chemical Modification of the Rieske Protein from Thermus thermophilus Using Diethyl Pyrocarbonate Modifies Ligating Histidine 154 and Reduces the [2Fe-2S] Cluster” Mary E. Konkle, Kaitlin E. Elsenheimer *, K. Hakala, Jenny C. Robicheaux *, Susan T. Weintraub, Laura M. Hunsicker-Wang, Biochemistry 2010, 49, 7272-7281. "Dications of 3-Phenyl-indenylidene dibenzo[a.d]cycloheptene: The role of charge in the antiaromaticity of cationic systems", Nancy S. Mills, Francine E. Cheng*; Joseph M. Baylan*, Cornelia Tirla, Jennifer L. Hartmann*, Kiran C. Patel*, Bart J. Dahl, and Sean P. McClintock, Journal of Organic Chemistry, ASAP, 2010; J. Org. Chem. 2011, 76, 645-653. "Dications of benzylidenefluorene and diphenylmethylidene fluorene: The relationship between magnetic and energetic measures of antiaromaticity", Catherine Do*, Julianne Hatfield*, Shirali Patel*, D.Vasudevan, Cornelia Tirla, and Nancy S. Mills, Journal of Organic Chemistry, ASAP, 2010; J. Org. Chem. 2011, 76, 181-187. 34 " Access to NMR spectroscopy for Two-Year College Students: the NMR Site at Trinity University", Nancy S. Mills and Michael Shanklin, , Journal of Chemical Education, in press, 2010. “Benzobis(imidazolium)-Cucurbit[8]uril Complexes for Binding and Sensing Aromatic Compounds in Aqueous Solution” Frank Biedermann, Urs Rauwald, Monika Cziferszky, Kyle A. Williams, Lauren D. Gann*, Bi Y. Guo*, Adam R. Urbach, Christopher W. Bielawski, and Oren A. Scherman, Chemistry A European Journal, 2010, 16, 13716-13722. “Circular Dichroism Spectroscopy in the Undergraduate Curriculum” Adam R. Urbach, Journal of Chemical Education, 2010, 87, 891-893. "Solid-Phase Synthesis of Peptide-Viologen Conjugates" Joseph J. Reczek, Elisa Rebolini, and Adam R. Urbach, Journal of Organic Chemistry, 2010, 75, 21112114. “Amperometric Determination of Glucose at Conventional vs. Nanostructured Gold Electrodes in Neutral Solutions” Marilyn Wooten, Jun Ho Shim, and Waldemar Gorski, Electroanalysis 2010, 22, 1275-1277. “Facilitation of NADH Electrooxidation at Treated Carbon Nanotubes” Marilyn Wooten and Waldemar Gorski Analytical Chemistry 2010 82, 1299-1304. 35 FACULTY PRESENTATIONS AT UNIVERSITIES AND AT SCIENTIFIC MEETINGS Steven Bachrach Seminars at University of Georgia and Texas Tech Michelle Bushey Seminar at Southwestern University “Grant Proposal Development in the Sciences”, Associated Colleges of the South Virtual Workshop, Oct. 29, 2010. M.M. Bushey, J.R. Shinkle, Christopher Schardon*, Kyle Meinhardt*, Identification of UV Absorbing Species in Arabidopsis Thaliana and Cucumis Sativus Seedlings, Pittcon 2010, Orlando, Feb. 28- Mar. 5, 2010. M.M. Bushey, K. Ritson, Unusual Partners Open Interesting Opportunities: Blending Chemistry and Art, CUR 2010, Ogden, UT June 19-22, 2010. M.R. Brodl, M.M. Bushey, C.W. Scholz, D.R. Smith, Undergraduate Research at Trinity University: Where we have been, Where we are, Where we are going, CUR 2010, Ogden, UT, June 19-22, 2010. Bert Chandler “Heterogeneous Catalysts from Au and Au-M Nanoparticles: Preparation, Characterization, and Michaelis-Menten Kinetics of Low-Temparature CO Oxidation” Iowa State Univ., October 14, 2010. Chandler, BD; Pursell, CJ; Gilbertson, JD; Long, CG; Hartshorn, H; Korkosz, RJ; “Old Tricks for New Dogs: Kinetics & Thermodynamics Studies of CO Oxidation over Au and Ni-Au Catalysts” Poster Presentation at the Gordon Research Conference on Catalysis. New London, NH, June 2010. Chandler, BD; Pursell, CJ; Gilbertson, JD; Long, CG; Hartshorn, H; Korkosz, RJ; “Old Tricks for New Dogs: Kinetics & Thermodynamics Studies of CO Oxidation over Au and Ni-Au Catalysts” Poster Presentation at the Gordon Research Conference on Catalysis. Biddeford, ME, June 2010. Laura Hunsicker-Wang “Probing the Factors that Govern the pH-dependent Reduction Potential in the Rieske Protein from Thermus thermophilus” (Poster Presentation) Gordon Conference - Metals in Biology, Ventura, CA Jan 2010 Nancy Mills "Fostering excellence in the first two years: Leveraging ACS resources to address transferable skills", Nancy Mills, Kristine Smetana, 66th Southwest/Southeastern Regional American Chemical Society Meeting, New Orleans, December 3, 2010 36 Adam Urbach "Cucurbit[n]uril-Based Sensing of Peptides and Proteins" 5th International Symposium on Macrocyclic and Supramolecular Chemistry (ISMSC), Nara, Japan, June 9, 2010 "Molecular Recognition of Peptides by Self-Assembled Synthetic Receptors" RISE Area Conference: Frontiers in Chemical Biology, San Juan, Puerto Rico, April 24, 2010 "Understanding Oligovalency" National Science Foundation Workshop on Physical Organic Chemistry, Austin, TX, Jan 9, 2010 Seminars at: University of Miami, Texas Tech University, New York University, Georgetown University, and University of Maryland. 37 DEPARTMENTAL SEMINARS Jan 21 – Summer Research Opportunities in Chemistry Feb 4 – Dr. Brian Bahnson (University of Delaware) “Exploring the Physiological Function and a Potential Bioscavenger Role of Phospholipase A2 Enzymes” Feb 11—Lauren Webb (UT Austin) “Measuring Electrostatic Fields in Proteins” Feb 18 – John Kozarich (Activx) “From Enzyme Chemistry to Proteomic Chemistry” Feb 25 – Vijay Ramalingam (Trinity University) “Design and Synthesis of Squaramide-Based Molecular Machines” Mar 11 – Joachim Weber (Texas Tech University) “ATJP Synthase-The World’s Smallest Known Rotary Motor” Mar 25 – Youngha Ryu (Texas Christian University) “Unnatural Protein Engineering; Biochemical and ” Apr 2 – Dr. Brent Sumerlin (Southern Methodist University) “New Stimuli-Responsive Macromolecules – Polymer-Protein Bioconjugates and ‘Sweet Tooth’ Micelles” Apr 23 – Dr. Kevin Chambliss (Baylor University) “Improved Analytical Methods for Monitoring Process Intermediates in Biomass-to-Ethanol Conversion” Sept. 16- Christy Landes (Rice University) “Single Molecule Biophysical Chemistry (What the heck is that?” Sept. 23- John Sibert (UT Dallas) “Redox-Active ‘Wurster-Type’ Receptors for Cation, Anions, and Complete Salts” Sept. 30- Melanie Sanford (U. Michigan) “C-H Bond Functionalization in Organic Synthesis” Oct. 7- Sergei Dzyuba (TCU) “Bioorganic Studies on Amyloids – Implications for Neurodegenerative Diseases” 38 Oct. 14- Michael Mayer (Texas Tech) “Synthesis via Entanglement” Oct. 28- Don Kurtz (UTSA) “How Microbes Sense and Detoxify Diatomic Oxygen and Nitrogen Species: The Non-Heme Iron Paradigm” Nov. 4- Henry White (U. Utah) “Structural Analysis of Single-Base DNA Damage Using Protein Nanopores” Nov.11- Karen Wooley (Texas A&M) “Sophisticated Plastics: Diverse Opportunities—from materials to Medicine for Will-Defined Polymer Chemistry” Nov. 18- Scott Grayson (Tulane) “The Preparation of Nanoscale Polymer Architectures for Improved Drug Delivery” Dec. 2- Renhau Li (UT Houston) “Structure and Regulation of a Blood-Clotting Receptor” 39 MAJOR INSTRUMENTATION IN THE CHEMISTRY DEPARTMENT Instrument Year Varian 500 MHz NMR spectrometer Bruker Tracer III-SD handheld XRF Varian 720-ES ICP-OES CD Spectrometer CS Bio CS336 Automated Peptide Synthesizer HEL parallel reactor system Revco Ultra Low Temp. Freezer Jasco J-815 CD Spectropolarimeter with Peltier Temperature Control Bio-Logic Stopped Flow System Thermo Scientific Biomate 5 UV-VIS Spectrophotometer Varian Saturn 2100T ion trap GC/MS with MS/MS Varian 3900 capillary GC Akta Prep. FPLC Biotek Absorbance Plate Reader Jasco UV-Visible Spectrophotometer New Objective Nanospray MS Source and 2005 Michrom Flow splitter Beckman Fluorescence Detector/Melles Griot Laser Beckman PA800 Capillary Electrophoresis Autosampler/software upgrades for HPLC 1100 Waters Preparatory HPLC PTI Fluorescence Microwell Plate Reader PTI.Model QM-7 Fluorescence Spectrometer ThermoFinnegan LCQ Deca XP Ion Trap MS with MALDI, ESI, LC (w/biology) Microcal VP-ITC Microcalorimeter(w/biology) Ocean Optics UV/visible spectrometer Dell PC Linux Cluster Agilent 6890N Capillary GC 2 Polax Polarimeters Nicolet Nexus 470 FT-IR BAS Epsilon Electrochemical Analyzer UVDetector with CE Flow Cell Finnigan GC-MS Varian Mercury 300 NMR Spectrometer SRI Instruments GC (2) Nicolet Nexus 470 FT-IR Quanta Chrome Inst. Co. Autosorb 1-C Chemisorption, Physisorption, and Pore Size Analyzer Varian Cary 100 UV-VIS Spectrophotometer Varian Atomic Absorption SpectrAA 220 FS Beckman P/ACE MDQ Capillary Electrophoresis Beckman HPLC 40 Acquired 2010 2010 2010 2009 2008 2008 2008 2007 2007 2007 2006 2006 2005 2005 2005 2005 2005 2005 2005 2005 2004 2004 2004 2004 2004 2004 2003 2003 2003 2003 2003 2002 2002 2002 2002 2001 2001 2001 2000 2000 BOARD OF ADVISORS MEMBERSHIP 2009-2010 The individuals listed below meet usually twice each year on the Trinity campus to advise the department on a variety of matters. The Board has been instrumental in assisting the department in fund-raising efforts, particularly for equipment. The Board members serve each spring as judges for the senior poster competition that are part of the McGavock program. We all owe these folks a great deal of thanks for their unselfish work on our behalf. Dr. Andrew Burke SSCI, Incorporated 3065 Kent Ave. W. Lafayette, IN 47906 Mr. Bruce A. Story Dow Chemical Texas Division Bld B-1470 Freeport, TX 77541-3257 Dr. Judy Guy-Caffey TETRA Technologies Technology Center 200 S. Trade Center Pkwy Conroe, TX 77385 Dr. Andrew L. Vance Lawrence Livermore National Laboratory PO Box 808, L-091 Livermore, CA 94550 Dr. Randle Collard 6601 NE New Brooklyn Rd. Bainbridge Island, WA 98110 Dr. Sue Weintraub Department of Biochemistry University of Texas Health Science Center 7703 Floyd Curl Dr. San Antonio, TX 78284-7760 Dr. Jodie Conyers University of Texas Health Science Center at Houston 6410 Fannin Street Suite 1100.15 Houston, TX 77030 Dr. Andrew Rusinko III, PhD Alcon Research Ltd., R0-19 6201 S. Freeway Fort Worth, TX 76134 41 Joshua Woody 23026 Fairway Bridge San Antonio, TX 78258 ALUMNET Trinity University, through the office of Alumni Relations, has set up a web site devoted to alumni information, and called ALUMNET. It includes information about events on campus, news about alumni, information about job openings, and other information of potential interest to alumni. There are online forms for posting of information and sending requests. The site may be found at the URL: www.trinity.edu/departments/alumni_relations/Anindex.htm. Alumni may also send information to Chemistry Department by contacting any of the following faculty by e-mail: Steve Bachrach steven.bachrach@trinity.edu Michelle Bushey mbushey@trinity.edu Bert Chandler bert.chandler@trinity.edu Jessica Hollenbeck Jessica.hollenbeck@trinity.edu Laura Hunsicker-Wang laura.hunsickerwang@trinity.edu Nancy Mills nmills@trinity.edu Chris Pursell cpursell@trinity.edu Adam Urbach adam.urbach@trinity.edu Finally, don't forget Facebook: http://www.facebook.com/home.php#!/home.php?sk=group_161512913892741&ap =1, or google facebook chemistry department alumni. Gifts and Donations The Chemistry Department gratefully acknowledges the support of friends and alumni during the past year. This support has come in the form of equipment donations, time, restricted and unrestricted monetary donations. All support, no matter what the form, helps us to better meet our mission. Unrestricted donations allow us to make special purchases during the year, and to support faculty and student research in ways that our regular department budget does not allow. We have been remiss in the past by not publicly thanking those who have supported our efforts. We hope to remedy that now and in future annual reports. Our supporters include American Chemical Society, John Burke, Randy Collard AMGEN PACMATCH GIFT PROGRAM, Jodie Conyers Jr., Yolanda Fintschenko and Andrew L. Vance, Andrew Gum, Lockheed Martin Corporation, Michael J.B. Rugh Victoria L. Tang, William R. Veal, Frank Walmsley 42