Material Safety Data Sheet
EMERGENCY NUMBERS:
(USA) CHEMTREC : 1(800) 424-9300 (24hrs)
(CAN) CANUTEC : 1(613) 996-6666 (24hrs)
(USA) Anachemia : 1(518) 297-4444
(CAN) Anachemia : 1(514) 489-5711
WHMIS
Protective Clothing
TDG Road/Rail
WHMIS CLASS: E D-1B D-2A
TDG CLASS: 8
PIN: UN2215 PG: III
Section I. Product Identification and Uses
Product name
MALEIC ANHYDRIDE
CI#
Not available.
CAS#
108-31-6
Chemical formula
(COCH)2O
Synonyms
2,5-Furandione, Cis-Butenedioic anhydride, AC-5583, Code
54326
Formula weight
Supplier
Anachemia Canada.
255 Norman.
Lachine (Montreal), Que
H8R 1A3
Material uses
For laboratory use only.
AC-5583
98.06
Supersedes
Section II. Ingredients
Name
CAS #
%
TLV
1) MALEIC ANHYDRIDE
108-31-6
100
Exposure limit: ACGIH TWA 0.1 ppm
(0.4 mg/m3):
Toxicity values of the
hazardous ingredients
MALEIC ANHYDRIDE:
ORAL (LD50): Acute: 400 mg/kg (Rat). 465 mg/kg (Mouse). 390 mg/kg (Guinea pig).
ORAL (LD50): Acute: 875 mg/kg (Rabbit).
DERMAL (LD50):
Acute: 2620 mg/kg (Rabbit). >20000 mg/kg (Guinea pig).
Section III. Physical Data
MALEIC ANHYDRIDE
Physical state and
appearance / Odor
pH (1% soln/water)
Colorless crystalline needles or white lumps or pellets. Sharp, acrid irritating odor.
Odor threshold
1.84 mg/m3 - 1.96 mg/m3
Percent volatile
Not available.
Freezing point
53°C to 55°C
Boiling point
202°C
Specific gravity
1.48 (Water = 1)
Vapor density
3.38 (Air = 1)
Vapor pressure
0.16 (60) mm Hg @ 20°C (122°C)
Water/oil dist. coeff.
Not available.
Evaporation rate
Not available.
Solubility
Readily hydrolyzed in water.
page 2/4
Not available.
Section IV. Fire and Explosion Data
Flash point
CLOSED CUP: 102°C (Pensky-Martens.)
Flammable limits
LOWER: 1.4% UPPER: 7.1%
Auto-ignition temperature 476°C
Fire degradation
products
Oxides of carbon (CO, CO2). Hydrocarbons.
Fire extinguishing
procedures
Use carbon dioxide, foam or water spray. DO NOT use dry chemical powder. Water or foam may cause frothing.
Wear adequate personal protection to prevent contact with material or its combustion products. Self contained
breathing apparatus with a full facepiece operated in a pressure demand or other positive pressure mode.
Fire and Explosion
Hazards
Combustible solid. This material in powder form is capable of creating a dust explosion. Dry chemical extinguishing
agents can react with maleic anhydride to produce large volumes of gases that could rupture equipment not
properly vented. Eliminate ignition sources and prevent build-up of static electrical charges. Ground all equipment.
Yields flammable vapors on heating above melting point. When heated to decomposition it emits acrid smoke and
fumes.
Section V. Toxicological Properties
Routes of entry
Inhalation and ingestion. Skin contact. Eye contact. Skin absorption.
Effects of Acute
Exposure
Harmful by ingestion, inhalation or skin absorption. Corrosive. May be fatal. Exposure to concentrations as low as 0.4
mg/m3 has been reported to produce eye and upper respiratory tract irritation. Target organs: eyes, skin, respiratory
system. 10 mg/m3 (MALEIC ANHYDRIDE) is immediately dangerous to life or health.
Eye
Skin
Causes severe burns and loss of vision. May cause double vision and photophobia. May cause permanent damage.
Vapor can cause a visual disturbance commonly known as "Halo vision". EYE IRRITATION (RABBIT, 24Hr): (FHSA)
CORROSIVE.
Causes severe burns. Causes burns which may be delayed. Readily absorbed through skin. Repeated contact with
this material may cause dermatitis, ulceration and allergic skin reaction.
Inhalation
Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract. Headache, nausea,
vomiting, sneezing, coughing, nosebleed, intense burning sensation in the throat, chronic bronchitis, chemical
pneumonitis and pulmonary edema which may have a delayed onset. Attention! Repeated or prolonged inhalation
may cause allergic respiratory reaction in some people.
Ingestion
Burns in mouth, pharynx and gastrointestinal tract. May cause nausea, vomiting, abdominal pain.
Section V. Toxicological Properties
Effects of Chronic
Overexposure
MALEIC ANHYDRIDE
page 3/4
Repeated exposure of workers to high concentrations have been reported to cause ulceration of the nasal mucous
membranes. May cause dermatitis, pulmonary oedema, allergic skin and respiratory reaction (chronic asthma,
bronchitis). Effects may be delayed. Carcinogenic effects: Not available. Mutagenic effects: Not available. Teratogenic
effects: Foetotoxic in animal. Toxicity of the product to the reproductive system: Not available. To the best of our
knowledge the chronic toxicity of this substance has not been fully investigated.
Section VI. First Aid Measures
Eye contact
IMMEDIATELY flush eyes with copious quantities of water for at least 15 minutes holding lids apart to ensure flushing
of the entire surface. Seek immediate medical attention.
Skin contact
Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Call a physician. Wash contaminated clothing before reusing. Discard contaminated leather articles such as shoes
and belt. If material is hot, treat for thermal burns and take the victim to hospital immediately.
Inhalation
Remove patient to fresh air. Administer approved oxygen supply if breathing is difficult. Administer artificial respiration
or CPR if breathing has ceased. Seek immediate medical attention.
Ingestion
Seek immediate medical attention.
Section VII. Reactivity Data
Stability
Unstable. Moisture sensitive! Conditions to avoid: High temperatures, sparks, open flames and all other sources
of ignition, contamination.
Hazardous decomp.
products
Maleic acid.
Incompatibility
Alkali metal ions and amines. At temperatures above 150°C, these materials (at concentrations as low as 200 ppm)
can trigger a rapid decomposition and polymerization reaction which will produce heat and gas and may cause
equipment to rupture. Water, calcium hydroxide, ammonium salts, dimethylamine, trimethylamine, alcohols, olefins,
sodium 2-benzothiazolethiolate, 1-methylsilacyclopenta-2,4-diene, oxidizing agents, acids, bases, pyridine, reducing
agents.
Reaction Products
Maleic anhydride reacts with water or moist air to form maleic acid and heat. Will not self-polymerize but can
undergo uncontrolled co-polymerization in presence of other monomers and catalysts.
Section VIII. Preventive Measures
MALEIC ANHYDRIDE
page 4/4
Protective Clothing in Wear self-contained breathing apparatus, rubber boots and heavy rubber gloves. Wear disposable coveralls and
case of spill and leak discard them after use.
Spill and leak
Evacuate the area. Eliminate all sources of ignition. Allow product to solidify if molten. Sweep up and place in
container for disposal. Avoid raising dust. Ventilate area and wash spill site after material pick up is complete. DO
NOT empty into drains. DO NOT touch damaged container or spilled material.
Waste disposal
According to all applicable regulations. Harmful to aquatic life at low concentrations. Can be dangerous if allowed to
enter drinking water intakes. Do not contaminate domestic or irrigation water supplies, lakes, streams, ponds, or
rivers.
Storage and Handling
Store in a cool place away from heated areas, sparks, and flame. Store in a well ventilated area. Store away from
incompatible materials. Do not add any other material to the container. Do not wash down the drain. Do not breathe dust.
Keep container tightly closed and dry. Protect from moisture. Manipulate under an adequate fume hood. Avoid raising
dust. Take precautionary measures against static discharges. Ground the container while dispensing. Use explosion proof
equipment. Use non-sparking tools. Empty containers may contain a hazardous residue. Handle and open container with
care. Minimize dust generation and exposure - use dust mask or appropriate protection. Take off immediately all
contaminated clothing. This product must be manipulated by qualified personnel. Do not get in eyes, on skin, or on clothing.
Wash well after use. In accordance with good storage and handling practices. Do not allow smoking and food consumption
while handling. Molten product should be stored under 70°C. Never use welding or cutting torch on or near drum (even
empty) because product (even just residue) can ignite explosively.
Section IX. Protective Measures
Protective clothing
Face shield and splash goggles. Impervious gloves, apron, coveralls, and/or other resistant protective clothing. Sufficient to protect skin. A OSHA/MSHA jointly approved
respirator is advised in the absence of proper environmental controls. If more than TLV, do not breathe vapor. Wear self-contained breathing apparatus. If mist and/or hot
vapors are present, use air-purifying respiratory or self-contained breathing apparatus as required. If handling hot material, use insulated protective clothing (boots, gloves,
apron, etc..). Do not wear contact lenses. Make eye bath and emergency shower available. Ensure that eyewash station and safety shower is proximal to the work-station
location.
Engineering controls
Use in a chemical fume hood to keep airborne levels below recommended exposure limits. Use explosion-proof
ventilation equipment. Do not use in unventilated spaces.
Section X. Other Information
Special Precautions or Corrosive! Toxic! Sensitizer! Causes severe burns which may be delayed! Harmful if
comments
absorbed through skin. May cause allergic skin and respiratory reaction. Hot melted
material causes thermal burns to eyes and skin. Do not breathe dust or vapor. Do not get in
eyes, on skin, or clothing. Avoid prolonged or repeated exposure. Use in a chemical fume
hood. Keep away from heat, sparks and flame. Moisture sensitive! Handle and open
container with care. Container should be opened only by a technically qualified person. Can
undergo uncontrolled co-polymerization in presence of other monomers and catalysts.
Molten product should be stored under 70°C.
RTECS NO: ON3675000 (Maleic anhydride).
1
3
1
NFPA
Prepared by MSDS Department/Département de F.S..
Validated 23-Nov-2012
Telephone# (514) 489-5711
While the company believes the data set forth herein are accurate as of the date hereof, the company makes no warranty with respect thereto
and expressly disclaims all liability for reliance thereon. Such data are offered solely for your consideration, investigation and verification.