C7 Bone Tissue / MC3 What are the functions of the skeletal system? What is the anatomy of a “long bone”? See Figure 7.1 - diaphysis - epiphysis - epiphysial plate - nutrient foramina - periosteum - endosteum - articular cartilage - perforating fibers How do osteocytes get nutrients and excrete waste products? What three components make up the skeletal system? What are osteogenic cells? Where are these cells found? What is an osteoclast? What terms are used to classify bone based on the shape of the bone? What is an osteoblast? Where do osteoblast come from? What do osteoblast produce? What happens to an osteoblast after it becomes “trapped” inside the lacuma? Why would an engineer classify bone as a composite material? What are the two substances called that make bone a composite? What characteristics do these different materials give bone? What are the two methods call for bone formatoion in human fetus and infants? What is the process of bone formation called? - perforating canal - trabeculae - spicules - spongy bone - compact bone - concentric lamellae - central canal (Haversian) - osteon - perforating canal - circumferential lamellae - endosteum - periosteum - perforating fibers What is interstitial growth? What preceeds intramembranous ossification? What precceds endochondral ossificaion? What is the epiphyseal plate? What happens at the epiphyseal plate at your late teens or early twenties? What do we then call this structure? How are nutrients and waste products transported between the central canal and osteous cells located beneath the periosteum? What is appositional growth? What is the term that describes the soft tissue that fills the marrow cavity of long bones and the spaces amid the trabeculae of spongy bone? What are the two forms of this tissue and how does it change as we age? Explain What is Wolff’s Law of Bone? Why is it important? What role in calcium homeostasis do these three substances play? - calcitriol (from skin) - calcitonin (from throid gland) - parathyroid hormone (from parathyroid gland) What is hydroxyapatite crystals? Why do they not form in most tissues? Why do they form in bone? What do they “seed” onto? Calcium is an important “reglatory ion” in many different mechanisms. So calcium homeostasis is critical for life. Hypocalcemia is more dangerous. Why? What is an early sign of hypocalcemia? What two substances do osteoclast secrete to reabsorb bone? What are the four stages for the healing of a bone fracture? What is osteoporosis?