Muscles Below is a mixed up summary of a muscle contraction Can you put it in the correct order? Order 1 2 3 4 5 6 7 8 9 10 11 Brief summary of a muscle contraction Motor nerve¶s impulse action to neuromuscular junction Sliding action of actin over myosin (Sliding Filament Theory). Calcium ions released from SR and binds with troponin Myosin globular heads combines with actin binding sites Tropomyosin covers binding sites, myosin no longer bound Impulse stops, calcium or ATP depleted, calcium ions return to SR Sodium ions ³leak´ into muscle cell initiating action potential which travels T-tubules to sarcoplasmic reticulum (SR). Conformational shift of tropomyosin, ³uncovers actin binding sites´. With ATP present, ATPase splits ATP to ADP + P + Energy Acetylcholine(ACH) released by synaptic vesicles, crosses synaptic cleft (Acetylcholinesterase enzyme breaks down ACH). Calcium actively ³pumped´ back to SR Hint to help 1 and 11 are correct Correct order