THE 16 th CONGRESS OF THE ROMANIAN SOCIETY OF ENDOCRINOLOGY WITH INTERNATIONAL PARTICIPATION Screening in endocrine diseases Endocrine incidentalomas Timişoara - România, October 23 – 25, 2008 1 Dear Colleagues! Welcome to the XVIth National Congress of Endocrinology with International Participation, being held in Timisoara, in October 23-25, 2008. The topics of this meeting (Screening in Endocrine Diseases and Endocrine Incidentalomas) have an important practical relevance. The congress will bring together prestigious and experienced specialists from Romania and abroad and also young endocrinologists. During this meeting we propose us to discuss conceptual, physiopathological and practical aspects, related to the declared topics. Our meeting will certainly generate an interchange of opinions between different Endocrinological schools and also between different generations. We are honored that this important event is held in our town, an attractive place, with old economic, cultural and scientific traditions. In the same time, we hope that you will enjoy your stay in Timisoara, where near the interesting objectives you can feel and understand the so called „spirit of Timisoara”. Prof. Dr. Ioana Zosin President of the Congress Timişoara, October, 2008. 2 CONGRESS SCIENTIFIC COMMITTEE Prof. Dr. Angela Borda Prof. Dr. Mihail Coculescu Prof. Dr. Ileana Duncea Prof. Dr. Simona Fica Conf. Dr. Carmen Georgescu Conf. Dr. Cristina Ghervan Prof. Dr. Liviu Gozariu Prof. Dr. Imre Kun Prof. Dr. Ioana Micle Conf. Dr. Aurora Miloş Prof. Dr. Voichiţa Mogoş Conf. Dr. Cătălina Poiană Dr. Mihaela Simescu Prof. Dr. Ioan Totoianu Conf. Dr. Horia Ursu Prof. Dr. Carmen Vulpoi Prof. Dr. Eusebie Zbranca Prof. Dr. Ioana Zosin CONGRESS ORGANIZATION COMMITTEE Prof. Dr. Ioana Zosin Conf. Dr. Aurora Miloş Dr. Melania Balaş Dr. Mihaela Vlad Dr. Corina Crista Dr. Ioana-Natalia Miloş Dr. Ioana Golu Dr. Dana Amzăr Conf. Dr. Dana David 3 INVITED SPEAKERS 1) Prof. Dr. Maria Alevizaki, Greece Screening for thyroid microcarcinoma: clinical issues and management 2) Prof. Dr. Emanuela Arvat, Italy Pitfalls in the screening of Cushing’s syndrome 3) Prof. Dr. Peter Bottermann, Germany Parathyroid incidentaloma 4) Prof. Dr. Rolf-C. Gaillard, Switzerland Growth hormone deficiency in adults: screening and impact of its replacement therapy 5) Prof. Dr. Hendrik Lehnert, Germany Evaluation and Management of the Adrenal Incidentaloma 6) Prof. Dr. Klaus Mann, Germany Thyroid incidentaloma - Risk stratification for thyroid carcinomas 7) Prof. Dr. Josef Marek, Czech Republic Pituitary incidentalomas 8) Prof. Dr. Hartmut P. H. Neumann, Germany Molecular genetic screening in paraganglial tumors 9) Prof. Dr. Jean-Louis Peix, France Incidentalome surrénalien - Problèmes de prise en charge 10) Prof. Dr. Istvan Szabolcs, Hungary Screening of thyroid dysfunction in elderly 11) Prof. Dr. Wilmar M. Wiersinga, Holland Screening of thyroid dysfunction during pregnancy 12) Dr. Holger S. Willenberg, Germany Indirect measures of hormone excess in adrenal incidentalomas 4 SCIENTIFIC PROGRAMME Thursday– 23rd October 2008 15.00 – 16.00 Symposium organized by BEAUFOUR IPSEN Chairmen: Prof. Dr. Liviu Gozariu, Prof. Dr. Ileana Duncea, Prof. Dr. Josef Marek Prof. Dr. Ana Maria Colao, Italy: MEDICAL THERAPY IN ACROMEGALY 16.00 – 16.30 Coffee break 16.30 – 16.55 Jean-Louis Peix: Service de Chirurgie endocrinienne, Centre Hospitalier Lyon-Sud, Lyon, France INCIDENTALOME SURRÉNALIEN - PROBLÈMES DE PRISE EN CHARGE 16.55-17.05 Ileana Duncea1, Carmen Georgescu1, Ioana Ilie1, Razvan Ilie2 1Department of Endocrinology, “Iuliu Hatieganu” University of Medicine and Pharmacy Cluj-Napoca, 2Clinic of Obstetrics and Gynecology II, Cluj-Napoca, Romania CARDIOMETABOLIC SYNDROME SCREENING IN POLYCYSTIC OVARY SYNDROME 17.05-17.15 Carmen Georgescu, Ileana Duncea Department of Endocrinology, „Iuliu Hatieganu” University of Medicine and Pharmacy Cluj-Napoca, Cluj-Napoca, Romania SCREENING OF BONE MINERAL DENSITY IN CHILDHOOD – CLINICAL USEFULNESS AND MANAGEMENT 17.30 – 18.30 Poster Session 19.30 Cocktail - Hotel Timişoara, Vienna Hall 5 Friday – 24th October 2008 8.30-9.00 Opening of the Congress 9.00 – 11.00 SESSION I - Screening in endocrine diseases Chairmen: Prof. Dr. Wilmar M. Wiersinga, Prof. Dr. Ioana Zosin 9.00-9.25 Wilmar M. Wiersinga Dept. of Endocrinology & Metabolism, Academic Medical Center, University of Amsterdam, The Netherlands SCREENING OF THYROID DYSFUNCTION DURING PREGNANCY 9.25-9.35 I.Z. Kun1, Ildikó Kun2, Zsuzsanna Szántó1, B. Szabó3, Ligia Coroş4 1Endocrinology Clinic, UMPh Tg.Mures, 2Clinic of Internal Medicine Nr. II, UMPh Tg.Mures, 3Clinic of Obstetrics & Gynecology Nr. I, UMPh Tg.Mures, 4Central Laboratory of Emergency Hospital County Mures PARTIAL SCREENING OF THYROID DYSFUNCTIONS IN PREGNANT WOMEN IN COUNTY MURES 9.35-10.00 Ioana Zosin Clinic of Endocrinology, University of Medicine and Pharmacy, Timisoara THE SCREENING OF SUBCLINICAL THYROID DYSFUNCTION (SCTD) IN HIGH-RISK GROUPS, ISSUED FROM AN IODINE REPLETE AREAPRELIMINARY RESULTS 10.00-10.10 Melania Balaş, Ioana Zosin Clinic of Endocrinology, University of Medicine and Pharmacy, Timisoara THE SCREENING OF THYROID FUNCTION IN AMIODARONE (AMD) TREATED PATIENTS 10.10-10.35 Istvan Szabolcs, Hungary Department of Endocrinology, National Medical Center, Budapest, Hungary SCREENING OF THYROID DYSFUNCTION IN ELDERLY 10.35-10.45 Mihaela Simescu¹, Mariana Sava¹, D. Ciovernache², A. Colda², H. Ursu¹, M. Bistriceanu³, Ioana Zosin4, Ileana Duncea5, G. Dragotoiu5, Geta Hazi5, I. Coamesu6, T. Harsan7, Luminiţa Stamoran8, E. Florescu9, M. Vitiuc10, M. Varciu11, I. Budura12, A. Fugaciu12, T. Hutanu13, D. Lepadatu14, H. Sulac15, M. Munteanu16, Loredana Parlog¹, Claudia Podia Igna17, S. Chivu¹; 1. “C.I. Parhon” Institute of Endocrinology, Bucharest; District Endocrinologists: 2. Bistrita Nasaud; 3. Craiova; 4. Timisoara; 5. Cluj; 6. Râmnicu Vâlcea; 7. Prahova; 8. Arad; 9. Suceava; 10. Piatra Neamt; 11. Brasov; 12. Deva; 13. Galati; 14. Braila; 15. Oradea; 16. Targoviste; 17. Sibiu, Romania 6 POPULATION SCREENING OF THE MEDIAN URINARY IODINE CONCENTRATION (UIC) AND HYPOTHYROIDISM IN PREGNANT WOMEN AND SCHOOLCHILDREN BETWEEN 2006-2008 AFTER THE IODINE SUPPLEMENTATION PROGRAM (ISP); RISKS AND BENEFITS OF ISP 10.45-10.55 Ionela Pascanu1,2, Claudia Banescu1, Camelia Gliga2 1) Genetics Department, 2) Endocrinology Clinic, University of Medicine and Pharmacy Tg. Mures THYROID DYSFUNCTION IN CHILDREN WITH DOWN SYNDROME 10.55-11.15 Coffee break 11.15-13.15 SESSION II - Endocrine Incidentalomas Chairmen: Prof. Dr. K. Mann, Prof. Dr. Carmen Vulpoi, Prof. Dr. M. Coculescu 11.15-11.40 Josef Marek Department of Internal Medicine, School of Medicine, Charles University in Prague, Czech Republic PITUITARY INCIDENTALOMAS 11.40-11.50 Monica Livia Gheorghiu1,2, Catalina Poiana1,2, Dan Hortopan1, Anda Dumitrascu1, Corina Chirita1, Mara Carsote2, Mihai Coculescu1,2 1“C.I. Parhon” National Institute of Endocrinology, 2“C. Davila” University of Medicine and Pharmacy, Bucharest COMPARATIVE ANALYSIS OF PITUITARY AND ADRENAL INCIDENTALOMAS 11.50-12.15 Klaus Mann, A. Matuszczyk Department of Endocrinology and Division of Laboratory Research, University of Duisburg-Essen, Germany THYROID INCIDENTALOMA-RISK STRATIFICATION FOR THYROID CARCINOMAS 12.15-12.25 H. Ursu1, Simona Jercalau1, D. Hortopan1, Mihaela Mihai2, T. Harsan3, A. Goldstein1 1National Institute of Endocrinology ”C.I. Parhon”, Bucharest,2 Clinical Institute Fundeni Pathology Department, Bucharest, 3Department of Endocrinology, Ploiesti, Romania MULTIPLE ENDOCRINE NEOPLASIA TYPE 1 (PITUITARY AND PARATHYROID INCIDENTALOMAS) ASSOCIATED WITH POORLY DIFFERENTIATED INVASIVE BREAST CARCINOMA-CASE REPORT 12.25-12.50 Peter Bottermann Technische Universität, München, Germany PARATHYROID INCIDENTALOMA 7 12.50-13.15 Carmen Vulpoi, Delia Ciobanu, Voichiţa Mogoş, Cristina Cristea, Letiţia Leuştean, Cristina Preda, Maria-Christina Ungureanu, Ioana Stoica, Mihaela Negru, E. Zbranca Department of Endocrinology, University of Medicine and Pharmacy “Gr.T.Popa”, Iasi THYROID INCIDENTALOMA – CONTROVERSIAL MANAGEMENT OF A CONTROVERSIAL ENTITY 13.15-14.30 LUNCH BREAK 14.30-17.00 SESSION III - Screening in endocrine diseases Chairmen: Prof. Dr. H. Neumann, Prof. Dr. Voichiţa Mogoş, Prof. Dr. P. Bottermann 14.30-14.55 Angela Borda1, C. Moldovan2, V. Bacarea3, Andrada Loghin4, Nicole Berger5 1,2,4University of Medicine and Pharmacy, Pathology Department, Târgu Mureş, 3University of Medicine and Pharmacy, Epidemiology Department, Târgu Mureş, Romania, 5Pathology Department, Hôpital Lyon Sud, France BENEFITS AND PITFALLS OF FINE NEEDLE ASPIRATION IN THYROID NODULES SCREENING 14.55-15.20 Maria Alevizaki Endocrine Unit, Department of Medical Therapeutics, Athens University School of Medicine, Greece SCREENING FOR THYROID MICROCARCINOMA: CLINICAL ISSUES AND MANAGEMENT 15.20-15.30 Mariana Purice1, E. Marcu2, A. Goldstein1, Nicoleta Ene1, Liliana Ionescu1, R. Purice3 1National Institute of Endocrinology "C.I.Parhon", 2SOFTWIN Romania, 3Institute of Mathematics "Simion Stoilov" of the Romanian Academy BIOMATENDO, THE DATE BASE FOR THE FOLLOW UP AND SCREENING OF THE PATIENTS WITH THYROID CANCER. 15.30-15.40 Cristina Ghervan1, Dana Dumitriu2, Mihaela Muresan1, S. Dudea2, Ileana Duncea1 1Endocrinology Department, UMF “Iuliu Haţieganu” Cluj-Napoca, 2Radiology Department, UMF “Iuliu Haţieganu” Cluj-Napoca US ELASTOGRAPHY OF THE THYROID GLAND: A NEW METHOD OF SCREENING FOR THYROID NODULES 15.40-16.05 Hartmut P. H. Neumann University Medical Center, Department of Nephrology and General Medicine Albert-Ludwigs-University, Freiburg i.B., Germany MOLECULAR GENETIC SCREENING IN PARAGANGLIAL TUMORS 8 16.05-16.15 Ioana Natalia Miloş1, H. P. H. Neumann2, Aurora Miloş1, Ioana Zosin1 1Department of Endocrinology of the University of Medicine and Pharmacy “V. Babeş” Timişoara, 2Section of Preventive Medicine, Department of Nephrology, University of Freiburg Medical Centre, Freiburg im Breisgau, Germany GENETIC SCREENING FOR MEN 2A IN TIMISOARA: DIAGNOSIS OF A FAMILY WITH A CYS634PHE MUTATION OF THE RET GENE 16.15-16.40 Emanuela Arvat, R. Giordano *, A. Picu, R. Berardelli, E. Ghigo Division of Endocrinology and Metabolism, Department of Internal Medicine, *Department of Clinical and Biological Sciences, University of Turin, Italy PITFALLS IN THE SCREENING OF CUSHING’S SYNDROME 16.40-16.50 Dumitru D. Brănişteanu, Simona Mogoş, E. Zbranca, Voichiţa Mogoş Department of Endocrinology, University Hospital “St. Spiridon” Iaşi SCREENING OF THE ADRENOCORTICOTROPHIC AXIS IN CUSHING-LIKE SKIN MODIFICATIONS INDUCED BY TOPICAL CORTICOID APPLICATION 16.50-17.00 Alice Albu1, Anca Zirnea1, Larisa Nitu2, Daniela Voicu2, Rodica Rotaru1, Florentina Vladareanu2, Simona Fica1,3 1Elias” Hospital, Endocrinology and Diabetes Department, Bucharest, 2National Institute of Transfusional Hematology, Bucharest,3„Carol Davila” University of Medicine and Pharmacy, Endocrinology Department, Bucharest ENDOCRINOPATHIES IN BETATHALASSEMIA MAJOR: WHO SHOULD BE SCREENED AND WHEN? 17.00-17.20 Coffee break 17.20-19.05 SESSION IV: Screening in endocrine diseases Chairmen: Prof. Dr. E. Zbranca, Prof. Dr. Simona Fica, Dr. H. Willenberg 17.20-17.45 E. Zbranca, Voichiţa Mogoş, Cristina Preda, Maria-Christina Ungureanu, Cristina Cristea, Letiţia Leuştean, Luminiţa Apostu, V. Zaharia, A. Aancute, Carmen Vulpoi Department of Endocrinology, University of Medicine and Pharmacy “Gr.T.Popa” Iasi THYROID ULTRASONOGRAPHY – POSSIBILITIES AND LIMITATIONS OF A SCREENING PROCEDURE 17.45-18.10 Simona Fica University of Medicine and Pharmacy „Carol Davila”, Endocrinology Department, “Elias” Hospital, Bucharest CLINICAL UTILITY OF INSULIN RESISTANCE SCREENING IN POLYCYSTIC OVARY SYNDROME PATIENTS: FACT OR FICTION? 9 18.10-18.20 Carmen Barbu1,2, L. Cima2, C. Stefan2, S. Florea2, S. Fica1,2 Davila” University of Medicine and Pharmacy, Endocrinology Department, Bucharest, 2„Elias” Hospital, Endocrinology and Diabetes Department, Bucharest IS THERE A ROLE FOR ROUTINE PTH MEASUREMENT IN OSTEOPOROTIC PATIENTS? 1„Carol 18.20-18.30 Dan Pereţianu1, Alexandrina Clodeanu1, Larisa IonescuCălineşti1, L. Radu2 1Societatea Civilă Medicală “Povernei”, Bucureşti, 2Societatea Civilă Medicală “Medcenter”, Bucureşti THE SCREENING OF TPO-ABS IN DIFFERENT THYROID DYSFUNCTIONS 18.30-19.00 PRIZE CEREMONY 19.30 Dinner Party- Hotel Continental Saturday- 24th October 2008 8.30-12.15 SESIUNEA V: Screening in endocrine diseases Endocrine incidentalomas Chairmen: Prof. Dr. R. C. Gaillard, Conf. Dr. Cristina Ghervan, Prof. Dr. H. Lehnert 8.30-8.55 Rolf-C. Gaillard Service d’Endocrinologie, Diabétologie et Métabolisme, University Hospital, Lausanne, Switzerland GROWTH HORMONE DEFICIENCY IN ADULTS: SCREENING AND IMPACT OF ITS REPLACEMENT THERAPY 8.55-9.20 Mihail Coculescu “C. Davila” University of Medicine and Pharmacy, Bucharest, “C.I. Parhon” National Institute of Endocrinology, PITUITARY INCIDENTALOMA 9.20-9.45 Hendrik Lehnert University of Lübeck Medical School, Lübeck, Germany EVALUATION AND MANAGEMENT OF THE ADRENAL INCIDENTALOMA 9.45-10.10 Holger S. Willenberg Department of Endocrinology, Diabetes and Rheumatology; University Hospital Düsseldorf, Germany INDIRECT MEASURES OF HORMONE EXCESS IN ADRENAL INCIDENTALOMAS 10 10.10-10.20 Corina Gălesanu1, MR Galesanu2, C. Ciubotariu2 University of Medicine and Pharmacy Iaşi, 2Osteodensitometry, Centre of Imaging and Radiology Diagnosis Iaşi DIGITAL X-RAY RADIOGRAMMETRY EFFICIENT CLINICAL METHOD TO ESTIMATING AND MONITORING BONE MINERAL DENSITOMETRY IN POSTMENOPAUSAL OSTEOPOROSIS 1Endocrinology, 10.20-10.30 Mihaela Vlad1, V. Serban2, A. Vlad2, Delia Reviczky1, Delia Panduru1, Ioana Zosin1 1Clinic of Endocrinology, University of Medicine and Pharmacy “V. Babes”, 2Diabetes Clinic, University of Medicine and Pharmacy “V. Babes” Timisoara THE USEFULNESS OF THYROID ULTRASONOGRAPHY FOR THE SCREENING OF THYROID DISEASES IN PATIENTS WITH TYPE 1 DIABETES MELLITUS 10.30-11.00 PRIZE CEREMONY 11.00-11.15 Coffee break 11.30 Poster session Chairmen: Prof. Dr. Maria Alevizaki, Prof. Dr. I.Totoianu, Conf. Dr. H. Ursu 12.15 Closing ceremony of the Congress 12.25 Meeting of the Romanian Society of Endocrinology 11 POSTERS SCREENING OF ENDOCRINE DISEASES 1. C. Barbu¹², D. Ionita², M. Pobereznicenco², A. Miron³, A. Roman², S. Fica¹ ² ¹„ Carol Davila” University of Medicine and Pharmacy, Department of Endocrinology and Diabetes, Bucharest, ²„Elias” University Hospital, Endocrinology Department, Bucharest, ³„Elias” University Hospital, Surgery Department, Bucharest RARE ENDOCRINE DISEASE ASSOCIATION REVEALED THROUGH COMPLETE SCREENING IN A PATIENT WITH CUSHING DISEASE 2. C. Barbu1, A. Roman2, M. Giscan2, C. Stefan2, L. Cima2 1„Carol Davila”University of Medicine and Pharmacy, Endocrinology Department, Bucharest, 2Elias Hospital, Endocrinology and Diabetes Department, Bucharest SCREENING OF HYPERTENSION AND HIPOPOTASSEMIA 3. Mara Carsote, Corina Chirita, Iulia Barbu, D. Peretianu, Catalina Poiana „C.I.Parhon” Institute of Endocrinology, Bucharest, Romania SCREENING OF VITAMIN D STATUS ON OBESE PATIENTS 4. Corina Chirita, Mara Carsote, Iulia Barbu, Anda Dumitrascu, Catalina Poiana „C.I.Parhon” Institute of Endocrinology, Bucharest, Romania PERIPUBERTAL SCREENING WITH GONADOTROPE RELEASING HORMONE TEST TO DIFFERENTIATE THE CONSTITUTIONAL DELAYED PUBERTY FROM HYPOGONADIC HYPOGONADISM 5. Lavinia Corneci1, Cristian Deciu1, Alice Albu1, Suzana Florea1, Delia Marta2, Simona Fica1,3 1„Elias” Hospital, Endocrinology and Diabetes Department, Bucharest, 2„Marius Nasta” Institute, Bucharest, 3„Carol Davila” University of Medicine and Pharmacy, Endocrinology Department, Bucharest ISOLATED NEUROSARCOIDOSIS: A RARE DISORDER IDENTIFIED BY SCREENING FOR INFILTRATIVE DISEASES IN A PATIENT WITH THICKENED PITUITARY STALK. CASE REPORT 6. Corina Crista Clinic of Endocrinology, University of Medicine and Pharmacy “Victor Babeş” Timişoara CUSHING’S SYNDROME- SCREENING, DIAGNOSIS AND THERAPEUTIC ASPECTS 7. Dana Liana David1, N. Hrubaru2, Daniela Grecu1, Lavinia Stelea2 1Biochemistry Department, 2Gynecoligy Department of UMF ”V. Babes” Timisoara SCREENING OF THYROID PEROXIDASE AUTO ANTIBODIES AMONG PREGNANT WOMAN – RELATION WITH OUTCOME OF PREGNANCY 12 8. Roxana Dinu1, E. Zbranca1, Cristina Preda1, V. Scripcariu2, D. Negru3, Irina Antonescu1, Elena Livadariu1, Ioana Luca1, Letitia Leustean1, Carmen Vulpoi1 1Department of Endocrinology, 2Department of Surgery, 3Department of Imagery, University Hospital “Sf. Spiridon”, Iaşi INCIDENTALLY DISCOVERED PRIMARY HYPERALDOSTERONISMDIAGNOSTIC PROBLEMS 9. Camelia Gurban1, Ioana Zosin2, M. Cojocaru3, Doina Drugărin4 1Biochemistry Department, University of Medicine and Pharmacy “Victor Babes”, Timisoara, 2Clinic of Endocrinology, University of Medicine and Pharmacy “Victor Babes”, Timisoara, 3Department of Clinical Immunology, Clinical Hospital “Colentina”, Bucharest, 4Immunology Department, University of Medicine and Pharmacy “Victor Babes”, Timisoara, IMMUNO-BIOCHEMICAL MARKERS RECOMMENDED FOR SCREENING IN POSTMENOPAUSAL OSTEOPOROSIS 10. Otilia Marginean1, Ioana Micle1, Marilena Lesovici1, Olaru Gabriela3, Ilie Constantin4, Roxana Gruescu1, Elena Jivet1, Ramona Gorasciuc1 1Clinical Children Hospital „Louis Turcanu” Timisoara, 2„Victor Gomoiu” Maternity of Timisoara, 3Bega Maternity of Timisoara THE NEONATAL SCREENING FOR CONGENITAL HYPOTHYROIDISM IN TIMIS AREA – 7 YEARES OF EXPERIENCE 11. Sorina Martin 1, Olivia Georgescu1, Simona Fica1,2 1„Elias” Hospital Bucharest, Endocrinology and Diabetes Department, 2„Carol Davila” University of Medicine and Pharmacology, Endocrinology Department HYPOGONADISM SCREENING IN DIABETES MELLITUS PATIENTS 12. V. Mogos1, E. Zbranca1, C. Cristea1, S. Mogoş1, C.Vulpoi1, N. Florea2, D. Ciobanu2, V. Rusu3 1Clinic of Endocrinology, University of Medicine and Pharmacy Iasi, 2Laboratory of Pathology, University Hospital “St. Spiridon” Iasi, 3Laboratory of Nuclear Medicine, University Hospital “St. Spiridon” Iasi THYROID CANCERS–THE SCREENING FOR THE TREND OF INCIDENCE AND THE HISTOLOGICAL PROFILE IN AN AREA OF MILD IODINE DEFICIENCY 13. V. Mogoş1, E. Popescu2, T. Popa1, S. Mogoş1, A. M. Stǎtescu3, C. Ştefǎnescu3, Al. Grigorivici4, S. Mihailovici5, E. Zbranca1 1Clinic of Endocrinology, University of Medicine and Pharmacy “Gr.T. Popa” Iaşi, 2Clinic of Dental Surgery U.M.F, 3Laboratory of Nuclear Medicine, “St. Spiridon” University Hospital Iasi, 3III Surgery Clinic U.M.F. Iaşi, 4Laboratory of Pathology U.M.F. Iaşi IS IT USEFULL THE SCREENING FOR HYPERPARATHYROIDISM IN PATIENTS WITH GIANT-CELL JAW TUMORS? 13 14. Anca Mureşan¹, Elena Lazăr¹, Alis Dema¹, Ramona Cioroboreanu², Cristian Suciu³, Izabella Şargan4 1Department of Pathology, UMF Timişoara, 2County Hospital Timişoara, 3Department of Histology, UMF Timişoara, 4Department of Anatomy, UMF Timişoara THE SIGNIFICANTLY DETERMINATION OF ER AND PR IN BREAST CARCINOMAS FOR ENDOCRINE SCREENING 15. Anca Mureşan¹, Elena Lazăr¹, Alis Dema¹, Simona Costi¹, Ramona Cioroboreanu², Cristian Suciu³, Izabella Şargan4 1Department of Pathology, UMF Timişoara, 2County Hospital Timişoara, 3Department of Histology, UMF Timişoara, 4Department of Anatomy, UMF Timişoara THE IMMUNOHISTOCHEMICAL EXPRESSION OF HER2 IN BREAST CANCER: A MARKER FOR THERAPEUTIC SCREENING OF PATIENTS 16. Corina Paul1, Velea I. 1, Mihaela Vlad2, Dana Amzăr2, Ionela Tămăşan1, Popa I. 1 1Clinic II Pediatrics, 2Clinic of Endocrinology, U.M.Ph. "V. Babeş" Timişoara SCREENING OF THE AUTOIMMUNE THYROID DISEASE (ATD) IN THE DIABETIC CHILD 17. Dan Pereţianu1, Larisa Ionescu-Călineşti1, Liviu Victor Radu2, Alexandrina Clodeanu1 1Societatea Civilă Medicală “Povernei”, Bucureşti, 2Societatea Civilă Medicală “Medcenter”, Bucureşti THE SCREENING OF TSH-RECEPTOR ANTIBODIES IN DIFFERENT FORMS OF HYPERTHYROIDISM 18. Dan Pereţianu1, Mara Carşote2, Catalina Poiana2, Dumitra Ion1, Alexandra Clodeanu1 1SCM “Povernei”, Bucharest, 2C.I.Parhon” Institute of Endocrinology, Bucharest THE ULTRASONOGRAPHICAL SCREENING OF DIFFERENT THYROID DISEASES. REEVALUATION AFTER 5 YEARS 19. Dan Pereţianu1, Mara Carşote2, Catalina Poiana2, Dumitra Ion1, Alexandra Clodeanu1 1SCM “Povernei”, Bucharest, 2„C.I.Parhon” Institute of Endocrinology, Bucharest THE USEFULNESS OF THYROID INVOLVEMENT SCREENING IN BREAST CARCINOMAS 20. Catalina Poiana, Mara Carsote, Raluca Trifanescu, Corina Chirita, Anca Popescu, D. Ioachim, D. Hortopan, B. Stanescu „C.I. Parhon” Institute of Endocrinology, Bucharest, Romania SCREENING OF POLINODULAR GOITER: THE VALUE OF CALCITONIN MEASUREMENT - TWO CASES REPORT 14 21. Anca Sirbu1,2, Claudia Lenghen2, Ramona Olaru2, Carmen Barbu1,2 1„Carol Davila” University of Medicine and Pharmacy, Bucharest, 2„Elias” Emergency University Hospital, Bucharest DO WE STILL HAVE TO SCREEN FOR INFERTILITY CAUSES IN A PATIENTS WITH HYPERPROLACTINEMIA AND GINECOMASTIA? 22. Szántó Zsuzsanna1, I.Z. Kun1, B. Szabó2, Ildikó Kun3 1Endocrinology Clinic, 2Clinic of Obstetrics and Gynaecology nr. I., 3Clinic of Internal Medicine Nr. II, University of Medicine and Pharmacy Tg.Mureş PARTIAL SCREENING OF THYROID DYSFUNCTIONS IN PREGNANT WOMEN HOSPITALIZED FOR GESTATIONAL PATHOLOGY ENDOCRINE INCIDENTALOMAS 23. Daniela Amzar, Ioana Golu, Melania Balas, Ioana-Natalia Milos, Ioana Zosin Clinic of Endocrinology, University of Medicine and Pharmacy “V. BABES”, Timisoara, Romania AN INCIDENTALLY FOUND PITUITARY ADENOMA ASSOCIATED WITH NEUROLOGICAL SIGNS -CASE PRESENTATION 24. C. Barbu1, C. Stefan2, L. Cima2, A. Roman2, M. Giscan2 1„Carol Davila” University of Medicine and Pharmacy, Endocrinology Department, Bucharest, 2Elias Hospital, Endocrinology and Diabetes Department, Bucharest PITUITARY INCIDENTALOMA REVEALED FOR THE SCREENING OF GYNECOMASTIA 25. M. Cornianu1, I. Golu2, A. Dema1, S. Taban1, A. Faur1, E. Lazăr1, Ioana Zosin2 1Department of Morphology, University of Medicine and Pharmacy “Victor Babes” Timisoara, 2Department of Endocrinology, University of Medicine and Pharmacy “Victor Babes” Timisoara THYROID METASTASIS OF A RECTAL CARCINOMA, INCIDENTALLY DIAGNOSED: CASE PRESENTATION 26. Simona Costi1, Marioara Cornianu1, Alis Dema1, Elena Lazar1, Ioana Golu2, Ioana Zosin2 1Departament of Pathology – University of Medicine and Pharmacy Timisoara, 2Departament of Endocrinology – University of Medicine and Pharmacy Timisoara INCIDENTAL PRIMARY CARCINOID IN A MATURE CYSTIC TERATOMA OF THE OVARY: CASE REPORT 27. Camelia Gliga, Ramona Cătană, Anisie Năsălean, Jozsef Balazs, Ionela Paşcanu, Imre Kun Clinic of Endocrinology, Tg. Mures ADRENAL INCIDENTALOMAS, DIAGNOSE AND TERAPY 15 28. Ioana Golu1, Marioara Cornianu2, Daniela Amzar1, Doru Bordos3, Aurora Milos1, Ioana Zosin1 1Department of Endocrinology, University of Medicine and Pharmacy “Victor Babes” Timisoara, 2 Department of Morphology, University of Medicine and Pharmacy “Victor Babes” Timisoara, 3Clinic of Surgery, University of Medicine and Pharmacy “Victor Babes” Timisoara BENIGN THYROID NODULE ACCOMPANIED BY INCIDENTAL PAPILLARY MICROCARCINOMA, UNDETECTABLE ON PREOPERATIVE IMAGING TESTS: CASE REPORT 29. C. Lichiardopol1, A. Saftoiu2, C. Popescu3, D. Gheonea2, B. Zaharia3 1Dept. of Endocrinology, University of Medicine and Pharmacy Craiova, 2Dept. of Internal Medicine, University of Medicine and Pharmacy Craiova, 3Dept. of Pathology, University of Medicine and Pharmacy Craiova ENDOSCOPIC ULTRASOUND-GUIDED FINE NEEDLE ASPIRATION IN THE EVALUATION OF ADRENAL INCIDENTALOMAS 30. Oros Stela, Balázs József, Szöcs Mihály1, Simona Mocan2, Piciu Doina3, Kun Imre Clinica de Endocrinologie Tg-Mures, 1Clinica ORL Tg-Mures, 2Anatomie Patologica Tg-Mures, 3Institutul Oncologic Cluj INCIDENTALLY DISCOVERED LINGUAL THYROID A CASE REPORT 31. Teodora Popa1, E. Zbranca1, Cristina Preda1, Ioana Stoica1, E. Tarcoveanu2, Felicia Crumpei2, Delia Ciobanu3, Roxana Alexe1, A. Florescu1, Carmen Vulpoi1 1Department of Endocrinology, 2Department of Surgery –Ist Clinic, 3Department of Anatomo-pathology, University Hospital “St. Spiridon” Iasi DIAGNOSTIC PROBLEMS OF ADRENAL INCIDENTALOMA–CASE REPORT OF AN ADRENAL CARCINOMA 32. Ramona Samoila1, Ionela Baciu1, Anda Dumitrascu1, Simona Galoiu1,2, M. Coculescu 1,2 1"C. I. Parhon" Institute of Endocrinology, Bucharest, 2Endocrine Department, “Carol Davila” University of Medicine and Pharmacy, Bucharest DILLEMA: PITUITARY INCIDENTALOMA AT A PATIENT WITH ACROMEGALOIDISM OR SPONTANEOUSLY REMITTED ACROMEGALY? 33. Ioana Stoica1, E. Zbranca1, Maria Christina Ungureanu1, Ion Poeata2, Delia Ciobanu3, Mihai Grigoras4, Roxana Dinu1, Raluca Furnica1, Carmen Vulpoi1 1Department of Endocrinology, UMF “Gr.T. Popa” Iasi, 2Department of Neurosurgery, UMF “Gr.T. Popa” Iasi, 3Department of Morpho-pathology, UMF “Gr.T. Popa” Iasi, 4Department of Imagery, Univ. Hospital “St. Spiridon” Iasi INCIDENTALLY DISCOVERED CEREBRAL METASTASTASIS IN A CASE OF DIABETES INSIPIDUS 16 34. Szántó Zsuzsanna1, I.Z. Kun1, J. Jung2 1Endocrinology Clinic, 2Institute of Pathology Târgu Mures, University of Medicine and Pharmacy Târgu Mures INCIDENTAL AND NONINCIDENTAL PAPILLARY THYROID MICROCARCINOMAS IN THE MATERIAL OF ENDOCRINOLOGY CLINIC AND INSTITUTE OF PATHOLOGY TÂRGU MUREŞ VARIA 35. Circo Eduard Endocrinology Department, Medicine Faculty – University „Ovidius” Constanta APOPTOSIS–PATHOLOGICAL IMPLICATIONS AND THERAPEUTIC BENEFITS 36. Ileana Coameşu Endocrinology Department, Emergency Hospital in Valcea THYROID FUNCTIONAL STATE FOR A GROUP OF PREGNANT WOMEN IN VALCEA AREA IN THE CONDITIONS OF SALT UNIVERSAL IODINATION 37. Monica Livia Gheorghiu1,2, Dan Hortopan1, Anda Dumitrascu1, Paula Chicos3, Mihai Coculescu1,2 1“C.I. Parhon” National Institute of Endocrinology, 2“C. Davila” University of Medicine and Pharmacy, 3student “C. Davila” University of Medicine and Pharmacy, Bucharest EFFICACY OF PITUITARY RADIOTHERAPY IN PATIENTS OPERATED FOR NON-FUNCTIONING PITUITARY MACROADENOMA 38. Monica Gheorghiu1,2, Corina Chirita 2, Margherita Matei2, Anda Dumitrascu2 1“Carol Davila” University of Medicine and Pharmacy, 2“C.I. Parhon” National Institute of Endocrinology BONE TUMORS IN LONG STANDING SECONDARY HYPERPARATHYROIDISM 39. Olga Ianas1, Lorand Savu2, Roxana Rosca1, Dana Manda1, Oltea Joja1, Marcela Covic3, Constantin Dumitrache1 1National Institute of Endocrinology C.I. Parhon, Bucharest, 2Genetic Lab SRL, Bucharest, 3National Institute of Geriatry and Gerontology Ana Aslan, Bucharest ENDOCRINE FEATURE OF AGING AND COGNITIVE FUNCTION: ASSOCIATION OF ESTROGEN RECEPTOR ALPHA GENE POLYMORPHISM 40. Dorina Galusca, Michaela Timar University of Oradea, Medicine and Farmacy Faculty MEDULLARY FAMILIAL THYROID CARCINOMA 17 41. Dana Manda, Suzana Vladoiu, Oana Popa, Liliana Ionescu, Mihaela Giurcaneanu, Carmina Busu, Diana Paun, Olga Ianas “C.I. Parhon” National Institute of Endocrinology THE EFFECT OF POLYUNSATTURATED FATTY ACIDS ENRICHED EGG CONSUMPTION IN INFLAMMATORY MARKERS: A STUDY ON HEALTHY VOLUNTEERS 42. Mihály Emõke¹, Kolcsár Melinda² ¹County Hospital Miercurea Ciuc, ²University of Medicine and Pharmacy, Pharmacologycal Department THE ANALYSIS OF THE EFECTIVNESS OF METFORMIN THERAPY IN POLYCYSTIC OVARIAN SYNDROME 43. Anisie Năsălean, Camelia Gliga, Imola Budan, Kun I., Balasz J., Ildiko Vicsi, Zsuzsanna Reti Clinic of Endocrinology Tg.Mureş INFLUENCE OF MENOPAUSAL STATUS ON THE METABOLIC SYNDROM 44. Ligia Radulescu1, Raluca Trifanescu 1,2, Anda Dumitrascu2, Mihail Coculescu 1,2 1“C.I. Parhon” Institute of Endocrinology, Bucharest, 2Department of Endocrinology, “Carol Davila” University of Medicine and Pharmacy, Bucharest SPHENOIDAL TUMOR, A SELDOM CAUSE OF UNILATERAL EXOPHTHALMOS 45. Mariana Stroe, T. L. Ciunganu, Gabriel Kollo, Cristina Balet, Luminita Pasca, P. Orbai, Gh. Dragatoiu, Georgeta Hazi, Ileana Duncea Clinic of Endocrinlogy, Cluj-Napoca SLEEP APNEA SYNDROME BEFORE AND AFTER IRRADIATION IN AN ACROMEGALIC PATIENT 46. Michaela Timar, Dorina Galusca University of Oradea, Medicine and Farmacy Faculty SYMPTHOMATHIC HYPERURICEMIA – THE HYPERTHYROIDISM. CASE PRESENTATION DEBUT ASPECT IN 47. Raluca Trifanescu1,2, Florin Alexiu2, Ligia Radulescu2, Mihail Coculescu1,2 1“Carol Davila” University of Medicine and Pharmacy Bucharest, 2“C.I.Parhon” Institute of Endocrinology, Bucharest TRH TEST IN THE DIAGNOSIS OF MILD TSH RESISTANCE IN TYPE IB PSEUDOHYPOPARATHYROIDISM 48. Raluca Trifanescu1,2, Ligia Radulescu2, Andra Caragheorgheopol1, Anda Dumitrascu2, Mihail Coculescu1,2 1Carol Davila” University of Medicine and Pharmacy Bucharest, 2“C.I.Parhon” Institute of Endocrinology, Bucharest 18 PITFALLS IN THE DIAGNOSIS OF POSTURAL HYPOTENSION IN AN ELDER PATIENT WITH NONFUNCTIONING PITUITARY MACROADENOMA – A CASE REPORT 49. Suzana Vladoiu, Sabina Oros, Oana Popa, Dana Dinu-Draganescu si Olga Ianas National Institute of Endocrinology C.I. Parhon, Bucharest, Romania SERUM LEVELS OF C-REACTIVE PROTEIN IN RELATION TO HORMONAL PARAMETERS IN METABOLIC SYNDROME 50. Carmen Georgescu, Bogdan Georgescu, Ioana Ilie, Cristian Weber, Simescu, Ileana Duncea University of Medicine and Pharmacy „Iuliu Haţieganu” Cluj-Napoca 1National Institute of Endocrinology C.I. Parhon, Bucharest BIOMARKERS AND PRESENT BIOINDICATORS IN THE SCREENING OF ENDOCRINE DISRUPTORS 1Mihaela 51. Carmen Georgescu1, B. Georgescu2, Ioana Ilie1, C. Weber2, Mihaela Simescu3, Ileana Duncea1 1Department of Endocrinology, „Iuliu Hatieganu” University of Medicine and Pharmacy Cluj-Napoca, Cluj-Napoca, 2Department of Ecology and Environment Protection, University of Agricultural Sciences and Veterinary Medicine ClujNapoca, Cluj-Napoca, 3National Institute of Endocrinology „C.I.Parhon”, Bucharest, Romania. BIOMARKERS AND BIOINDICATORS IN ENDOCRINE DISRUPTER SCREENING 19