http://biosciences.sonydadc.com
Sony DADC
BioSciences Business Unit
February 2015
Outline
• Sony DADC & BioSciences
• Recent Sony DADC client projects
• A Unique Chain for Smart Polymer Parts
02/2015
Confidential
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Sony DADC is part of the Sony Corporation
Revenue: $75.4 B
Operating income: $257 M
Employees:~146,000
Mobile Products &
Communications
$15.8 B
Game
Imaging Products
& Solutions
Home
Entertainment &
Sound
Devices
$9.5 B
$7.2 B
$11.3 B
$7.7 B
$8.1 B
$4.9 B
Note: figures from FY13/14; Total Sony revenue does not equal to sum of business units due to consolidation of $4.5 B.
02/2015
Confidential
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$9.6 B
$1.6 B
• Global footprint with 12
replication and 15
distribution sites
• Revenue:
1.6 B US$ (FY13)
• 5500 employees
• Since 1987 in Austria
• Main customers:
Sony Music, Sony
Pictures, Sony Computer
Entertainment, Warner
Group, EMI, EA,
Universal, Disney
02/2015
• Provision of digital supply
chains and authoring
services for the music
and video industry
• Global footprint with 10
operations and
development sites
• Revenue:
130 Mio. US$ (hereof
20 Mio. US$ in EU)
• 500 employees
• Since 2001
• Main customers:
EMI, Sony Music, Warner
Music, iTunes, Amazon,
BBC, Sony Pictures
Confidential
BioSciences
• Manufacturing and
distribution of optical
media (DVD, CD, Blu-ray
Disc)
New Media Solutions
Optical Media Supply Chain
Overview of Sony DADC Austria AG’s Business Units
• Design and production of
medical lab on a chips for
diagnosis and
pharmaceutical testing
• Manufacturing in Austria
serving global business
• Revenue:
15.2 Mio. US$
• about 110 employees
• Since 2009 in Austria
• Main customers:
oQuanterix
oShimadzu Corp.
oSony Medical BU
oRainDance Technologies
oBioMérieux
oSingulex
oOPKO Diagnostics
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Sony DADC BioSciences is represented in the EU,
US and Japan
Iris Bergmair
Business Development EMEA
Salzburg, Austria
Iris.bergmair@sonydadc.com
+43 6246 880 8131
Tsukasa Murota
Business Development APAC
Salzburg, Austria
tsukasa.murota@sonydadc.com
+43 6246 880 87581
Ali Tinazli
Veronika Eibl
Business Development Americas
Cambridge, MA, US
ali.tinazli@am.sony.com
+1 617 674 7733
Office Manager BioSciences
Headquarter
Salzburg, Austria
biosciences@sonydadc.com
+43 6246 880 333
02/2015
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Sony DADC is uniquely positioned to answer the emerging
needs for microstructured polymer devices in Life Sciences & IVD
BioSciences consumables business
Disc business
Decrease in feature size
Decrease in feature size
Increased information capacity per disc
Increased functionality on-chip
25/50 GB
50
Increased # of assays per chip
GB
40
30
20
5/9 GB
10
0
Smart polymer consumables for
bio applications
Simple consumables
for central lab
bio applications
Multiplexed
assay
e.g. Cuvettes,
micro-titer plates
0.7 GB
Detection
area
Separation, actuation, etc.
Shortest pit length
Pit height
0.83µm
0.15µm
0.40µm
0.10µm
02/2015
0.15µm
0.07µm
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Sony DADC is uniquely positioned to answer the emerging
needs for microstructured polymer devices in Life Sciences & IVD
BioSciences/Medtech consumables
business
Disc business
•
•
•
•
•
•
•
•
Polycarbonate disc
Sputter coated with aluminum
Spin coating with a protective lacquers
Packaged and shipped
02/2015
Confidential
Polypropylene slide
Sputter coated with steel
Coating with hydrophobic materials
Packaged and shipped
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Sony DADC - Meeting the needs of device manufacturing for
Life Sciences and IVD
Successful
productization
Mass manufacturing
(1000 - millions of units)
Mass manufacturing
(1000 - millions of units)
gap
Prototyping
(1-1000 units)
Prototyping
(1-1000 units)
R&D
R&D
Crossing the gap from prototyping to mass manufacturing introduces critical decisions to be made
We invite you to make the journey to productization with Sony
to make a smooth and effective transition from prototyping to mass manufacturing
02/2015
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Our partnering model for development and manufacturing &
supply of smart polymer parts to biomedical companies
Business Model
B2B
OEM
SONY DADC
Distribution
Sales force
Biomedical
company
Customer 1
Customer 2
Customer 3
Legal Framework
Non-Disclosure
Joint-Development
Supply
Collaboration Stages
Feasibility
Development
Mass Production
Technical & Financial
Due Diligence
Prototype Iteration and
full Productization Program
Scalable Manufacturing,
QC, ISO-requirements
02/2015
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Outline
• Sony DADC & BioSciences
• Recent Sony DADC client projects
• A Unique Chain for Smart Polymer Parts
02/2015
Confidential
13
Client project: Plastic MALDI - mass spectroscopy slides for
Kratos Analytical/Shimadzu Corporation
Jointly developed by
•
•
•
Sony DADC
Technical University of Vienna
Kratos Analytical
Benefits and features
•
•
polymer and single use
cost effective
Launched in May 2011
Complete product solution by Sony DADC
Packaged and labeled targets
02/2015
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Client project : Microdroplet microfluidic chip for the
Thunderstorm system by RainDance Technologies
Benefits and features
• single-use consumable for a digital PCR
• generates 1,000,000 picoliter droplets per sample
• can process two samples at the same time
• each droplet works as single PCR reaction chamber
• detection of 1 mutant DNA in the background of 1 million wild-type DNA
• stackable for fully automated handling
Droplet
aqueous
interior
Droplet generation
10k/sec
AGCT
Polymerase
DNA
Primer
Carrier oil
exterior
Droplet chip „HeatwaveTM TS“
Source: RainDance
Technologies
droplet
stabilizer
Press Release – February 6th, 2012
24.04.2015
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Client project : Development of cell sorting chip for Sony‘s cell
sorter SH800
Jointly developed by
•
•
Sony DADC
Sony Medical Business Unit
Benefits and features
•
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•
Precise alignment bonding
Fluorescence activated cell sorting (FACS)
Customized labeling with bar code and packaging solution
Cell sorting chip
Launched in July 2012
Cell sorter SH800
02/2015
Confidential
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Client project : Sputter coating of LED reflectors at high volumes
Jointly developed by
•
•
Sony DADC
Metal Plastics Putz
Benefits and features
•
•
Standardized and fully automated sputter coating of LED reflectors
Improvement of sputter coating regarding
• Reflectance
• Durability
• Thermal load
• Color fade-resistance
• 3 months from kick-off to first delivery
LED reflector with aluminum coating
Launched in December 2012
...testing different materials for mood lighting applications
02/2015
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Client project : Development of Quanterix SimoaTM
Jointly developed by
•
•
Sony DADC
Quanterix
Benefits and features
•
•
•
24-array polymer discs for single molecule
fluorescence detection
High volume, low cost production of arrays
possible using Blu-ray technology
Integration of arrays with fluidics enables fully
automated load and seal
24-array disc
Launched in July 2011
500K Wells
02/2015
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Client project : Development of Quanterix SimoaTM smart
polymer consumable
Simoa disc
Press Release – August 07th, 2013
02/2015
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Single Molecule Arrays (Simoa™) provide a digital advantage
• Reaction volumes 2 billion times smaller
• Single molecule resolution
• 1,000x improvement in sensitivity
SiMoA (Digital)
0 aM
3.5 aM
C Beads in the Array
02/2015
Confidential
3.5 fM
D Single Molecule Signal
10 µm
Rissin et al., Nat. Biotechnol. 2010, 28, 595-599
350 aM
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Client project: Microtiter plate for the Sgx ClarityTM System
Jointly developed by
•
•
Sony DADC
Singulex
Benefits and features
•
Manufactured as a one-piece molded microtiter plate
• High optical transparency
• High purity and low fluorescence
• Meet Singulex’ high cleanliness requirements
Microtiter plate for Singulex
Launched in March 2014
02/2015
Confidential
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Outline
• Sony DADC & BioSciences
• Recent Sony DADC client projects
• A Unique Chain for Smart Polymer Parts
02/2015
Confidential
31
We offer a unique value chain for OEM supply of microstructured
polymer devices to Life Sciences & IVD – with proven upscaling
capabilities
ISO 13485 certified and GMP ready
Sub-micron precision
DESIGN
MASTER
PLATING
MOLDING
MASTERING
DESIGN
• computational fluid
dynamics
• application expertise
• design for
manufacturing
COATING
ETCHING
• micromechanical
engineering
• lithography
• electroforming
• mechanical
machining
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PACKAGING
LOGISTICS
BACK-END PROCESSING
FABRICATION
MASTERING
CONTENT
FILLING
BONDING
FABRICATION
BACK-END PROCESSING
PACKAGING
LOGISTICS
• optical precision
injection
• electrode printing
• integration of biosensors
• coating
• bonding
• immobilization of reagents
• content filling
• etching
• multi-component
assembly
• packaging
• shipping
• tracking
• cash collection
• inventory
management
molding
• lamination
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We have the proven expertise to convert glass, silicon and metal
devices to polymer whilst retaining application-specific properties
Mass manufacturing material
Variety of polymers
Glass
• PP
• PC
• COC/COP
Silicon
• PMMA
• PS
• etc.
Metal
Customizable application specific properties
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•
•
•
02/2015
low background fluorescence
rigidity
electrical conductivity
surface properties
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Converting existing smart consumables materials to polymer
delivers improved scalability and reliability, as well as reduced
costs
Sony DADC‘s key capabilities for conversion to polymer:
• Optical Disc Microstructuring Technology to replace silicon, glass, PDMS
• Ultra low background fluorescence polymer chips to replace silicon, glass, PDMS
• Coatings on polymer to add features – glasslike, metal, silicon, oxides
MALDI –MS plates
Array chip
Planar optical chip
for label-free detection
Microdroplet chip
Steel Replacement
Silicon replacement
Glass replacement
PDMS replacement
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Reliable and customizable mastering of microstructures
Digital customizable mastering technology
• Multi height features possible
• Layer height: 100nm – several mm
• Aspect ratio: up to ~12:1 max
• Small structure size
• Pillar diameter:
• Pillar height:
• Pitch:
• Short turn around time
Molded pillar structure
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8 µm
53 µm
20 µm
Microinjection molding
Low radius of curvature
High aspect ratios
Precise micro-features
• Well diameter:
• Well depth:
• Wall width:
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24 µm
36 µm
5 µm
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Back end processing - coating
Leading expertise in numerous coating technologies
Deposition of various materials
Polymer printed with silver ink
– Inorganic coatings
• Al, Au, Ag, Ni, Cu, Cr, SiO2, SiN, SiON, SiCO2,
Al2O3, Ta2O5, GeN, ZnS, MgF2, TiO2,
steel and others
Applications
– Optical filter layers
– Biocompatible layer
– Wave guide layer
Metal coated MS polymer slides
Oxide coated MS polymer slides
Surface treatments
– Activation
– Hydrophilization
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Back end processing - coating
Mimicking glass chip properties
Tuning of surface properties by Sony’s proprietary coatings
glass
polymer
Change in surface tension
Glass like coating
02/2015
polymer + coating
Improves device performance
Minimizes need to change glass surface
chemistry
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Back end processing – bonding and lamination
Multiple bonding technologies customized to application needs
Multi-cavity bonding
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Thermal fusion bonding
Solvent bonding
Pressure sensitive adhesive (PSA) bonding
Lamination
Laser welding
Combination of the above
Laminated polymer chip
PSA bonded chip
150µm
14µm
50 µm
Wide channel bonding
25µm
2700µm
02/2015
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Sony DADC’s World’s First Automated Bonding Liner Enables
Mass-Production of µ-fluidic Chips for a Variety of Applications
Designed and developed by Sony DADC, proprietary
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Lamination liner: full automated lamination for microfluidic
solutions
• integrated film cutting,
• surface activation,
• bonding & visual inspection system
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Design for manufacturing
Comprehensive selection of QC measurement technology
Surface profilometry
Confocal microscopy
Coordinate measurement system
Contact angle measurement
In-line video inspection
Light microscopy
Atomic force microscopy
Ellipsometry
Scanning electron microscopy
Even further measurement techniques available through Sony network
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QC: Check fulfillment of customer requirements
Geometrical customer requirements
Biological / functional requirements
Optical requirements
spotting of slide
(Scratches, shadows, cosmetical defects, …)
spotted droplets
Judgements always get
saved in QC database
Scratches are critical
to application
Sample must stay within well, no spreading!
(Otherwise cross contamination between patient samples!)
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Certificates
Manufacturing is centered in Salzburg, Austria
at our ISO 13485, ISO 14001 and ISO 27001
certified facility.
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In Summary …
• Sony DADC & BioSciences
A global OEM supplier of smart polymer parts
for the IVD and life sciences industries
• Recent Sony DADC case studies
Several products for IVD and Life Sciences applications on
the market, many further in development
• A unique value chain for smart polymer parts
One partner from prototyping to mass production - incl.
back-end processing and logistics; ISO 13485 certified facility
02/2015
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Thank You for Your Attention!