Presentation to the
GBC Bioscience Commitee
February 2015
Origin of Johns Hopkins
Johns Hopkins, the Quaker merchant,
banker and businessman, left $7 million in
1873 to create The Johns Hopkins
University and The Johns Hopkins
Hospital, instructing his trustees to create
new models and standards for medical
education and health care.
• 1876: Johns Hopkins University opens
• 1889: Johns Hopkins Hospital opens
• 1893: School of Medicine opens
Since its inception by an original innovator, Hopkins has
continued to lead in discovery with exceptional people,
research, and facilities
People
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36 Nobel Laureates, 34 American Nobels (Lasker Award), 26 elected to National Academy
of Sciences, 54 elected to Institute of Medicine, 4 Presidential Medals of Freedom
•
>$6.7B in revenues and largest employer in state of Maryland
Research
•
Largest recipient of federal research funding >$2B FY2012 (#1 for 34 years in a row)
Facilities
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6 hospitals, 4 suburban health care & surgery centers, 30+ outpatient centers
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100+ Core facilities
•
Presence or affiliation in over 40 countries
Exceptional researchers produce exceptional results
But we can do more with the technologies that are developed
from our research
JHTV’s mission is to maximize the impact of JHU’s
excellence in research by facilitating the translation and
commercialization of discoveries into accessible
technologies, products and services for the benefit of
society.
Because we know that an Innovation Ecosystem is
important to JHU and more broadly, to Baltimore
Brings Products to the
world
Improves
competitiveness and
retention
Provides additional
funding sources to the
University
Promotes regional
economic development
6
So we examined how we could do a better job in supporting
innovation
Innovation
Committee:
Implementation of
the Entrepreneurial
Resources
Coordination of
industry activities
across JHU
- Commercial
Advisory Group
FastForward
Technology
Licensing and
Analytics
Social Innovation Lab
DreamIt
And our Innovation Committee made these recommendations
Innovation Committee
Recommendations
Space
Services
Funding
Office Space
Lab Space
Design Studio
Pre-Seed Grants
Investment Fund
Mentorship
Corporate Partnerships
Entrepreneur Training
Core Facilities
Today’s conversation is about our
commitment to an Innovation Industry
• Provides affordable, turnkey space for start up
companies and venture concepts who wish to locate
near JHU campuses
• Provides resources to entrepreneurs that will
augment their experience including networking
events, access to subject matter experts, business
analysis support, educational programming, and
introductions to funding sources
Our 2 current locations provide different
offerings
•
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FastForward Homewood (Stieff building) at capacity with
12 companies – all with lab
FastForward East 1.0 opened in Rangos building Jan 2015
with ~ 6k s.f of co-working, office and lab space
• Open seating with private lockers for 28
• 6 dedicated offices
• 7 benches in shared wet lab space with adjoining offices
More space for FastForward East 2.0:
• 30k s.f. to open in 2016 at 1812 Ashland
FastForward East: Opened January 2015
FastForward East will be a part of the Science +
Technology Park
•
88 acres located next to Johns Hopkins
Hospital and East Baltimore Campus
•
1st Building: John G. Rangos, Sr. Building
•
118,182 square feet dedicated to life science
building space
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22-story Graduate Student Housing Building
•
21,364 square feet of laboratory facilities for
the Maryland Department of Health and
Mental Hygiene Public Health
•
Plans for a hotel and life science building
FastForward East will benefit from its location
near other innovative Science + Technology Park
tenants
We also are increasing Services to nurture our
entrepreneurs and start-ups
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Carey Entrepreneurship Bootcamp
DreamIt
I-Corps program
Mentors in Residence
Social Innovation Lab
Express License for Faculty Start ups
Commercialization Academy
Committee on University Policies
2014 JHU Entrepreneurship Bootcamp
 70 participants from Johns Hopkins East
Baltimore Schools
• 47% Graduate students and residents
• 42% Faculty
• 11% Post docs
 32 departments represented
 Positive (4.3 out of 5) feedback on the
curriculum and the program
DreamIt Health
 9 companies in 2014 cycle
• 5 of the 9 companies had a JHU affiliation
• 4 of the 9 companies (3 JHU affiliated) have term sheets
for >$500k seed round or committed revenues
 2015 cycle kicked off January 2015
 2015 partners: JHU, BHI/EAGB, UMB, Abell, DBED
I-Corps Program for Start Up Training
I-Corps Fall 2014 (JHU joined DC-node in June 2014)
• 4 JHU teams accepted to upcoming Regional I-Corps
(representing both SOM and WSE)
• 1 JHU company accepted to the National NIH I-Corps
(have to be NIH SBIR recipient); received $50k as accepted
team
 Both programs provide real world, hands-on training on how
to successfully incorporate innovations into successful
products.
 Benefit: Helps teams make a go/no-go decision by validating
their technology's market potential and identifying a solid
product-market fit and building a viable business model.
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Mentors in Residence
 6 participants for 2014, launched in August to work with
students and faculty to bring deep domain expertise to help
accelerate the path of our promising technologies toward
market success; brought on 14 new MIRs in 2015
 MIRs are encouraged to develop close ties with our
inventors, entrepreneurs, and technology licensing team in
order to help JHU further develop these technologies
 Areas of expertise include:
• Personalized Medicine, Life Science Tools & Services,
Oncology Development, Genomics, Computational
Discovery, Software, Medical Device, Engineering,
Angel/Venture Investment, General Business
Social Innovation Lab (SIL)
 SIL has supported 33 social enterprises
 These enterprises have received approximately $1.5M to
further their work
 In the fall of 2014, SIL received 40 applications, mainly
from students in SPH, WSE, and SOM
Express License for Faculty Start-Ups
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Implemented July 2014
Vetted with local law firms who advise start-ups
5 JHU start ups year to date
4 of 5 used express license
Express license has required substantially less time
for negotiation, reducing the time to close a deal on
average from four months to less than two weeks
Commercialization Academy
 Supports diverse science career training
• Undergrads, graduate students, and post docs
 Supports needs of analytics group within JHTV: reviewing
450+ disclosures received annually across JHU
 Responsibilities include assessing market value proposition,
IP position, competition, and development risk
 Plan to augment current group of 12 interns from across
the JHU schools
Funding and Corporate Deals
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Maryland Innovation Initiative (via TEDCO)
Undergraduate Entrepreneurship Fund
Recent Industry Deals
Plan for pre-seed funding
Plan for investment fund
Maryland Innovation Initiative
- a TEDCO (State of Maryland) Program
 3 dedicated ‘site miners’ who serve as industry
mentors to faculty with a focus on commercial
relevance of the invention
 52 Awards to date; average grant size ~$100k
 Funded projects/companies representing SOM, WSE,
JHSPH, Peabody including many joint SOM/WSE
collaborations
 9 funded projects are now Maryland based startups
 Total JHU funding for PIs and companies FY 1315 ~ $5.05M
Undergraduate Entrepreneurship Fund
 Established with $300,000 gift from Ralph O’Connor
(KSAS grad) in October 2014 to support:
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Grants for teams of $5,000-$10,000
Resources for writing business plans
Marketing, legal, and accounting information
Information on filing for IP protection
Connections with network / investors
Seating in FastForward
A web site to provide a set of translational and
entrepreneurial resources
Investments and Partnerships - Closed
MedImmune
 5 year $6.5 Million agreement signed 12/13
 Focusing on 6 academic partnerships in areas of mutual interest as
well as shared educational efforts
 Initial faculty PI’s are Felipe Andrade, Michael Betenbaugh, Peter
Calabresi, Lloyd Miller, Ken Pienta, Jeff Rothstein, Bradley Undem
 Interest in project based support of FastForward, starting with a
$50,000 commitment in support of REACH grant
Roche
 $750,000 in funding for projects in Cancer Immunology; project
proposals submitted 9/15/14 for projects in ophthalmology
Investments and Partnerships - Closed
Novo Nordisk
 Hopkins invited to participate in a competitive funding process in
2013 and received $1.45 million in funding for three investigators:
• Functional study of the novel anti-diabetic adipokine, CTRP12:
William Wong, Ph.D.-$500,000 Early Exploration Award for 2
years
• Pluripotent Stem Cell Therapies for Diabetic Retinopathy: Elias
T. Zambidis, Ph.D.-$450,000 Early Exploration Award for 2
years
• A Novel Treatment Approach for Type 2 Diabetes and Obesity
Related Diseases: Jonathan D. Powell, MD, PhD-$500,000 Proof
of Principle Award for 2 years
Investments and Partnerships - Closed
Toshiba
 Aquilion ONE ViSION EDITION CT Scanner placed at
Hopkins in July 2014
 Twelve year relationship centered on testing and development of
6 CT scanners, leading to the development of the top of the line
CT scanner for the cardiovascular system
 Testing of efficacy and efficiency of cardiovascular CT
technology started at Hopkins and has led to a transformation in
the practice of cardiology in the US and abroad
 Toshiba and Hopkins are collaborating in the area of Big Data;
the first joint project focuses on novel strategies for diagnosing
and treating head and neck cancers
Committee on Policy Recommendations
 Convened initially October 2014
 Formed to review recommendations of the
Innovation Report and identify strategies to
implement changes proposed by the committee
 Committee includes Provost’s office, deans, and
administrators from Homewood and East
Baltimore
Metrics for measuring success of the Innovation
Effort
Where do we want to be in 3-5 years?
• Impact to society as our inventions reach market
• Increase number of funded start ups
• Vibrant innovation ecosystem that attracts capital
to translate our research to products
We have a robust start-up ecosystem that can
be an even larger engine of growth
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Since 2000, more than 100 spinoff companies created around
JHU IP
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Startups have raised more than
$476M in funding
•
40 projects received $100k grants
each for a total of $4.2 million of
Maryland funding
•
Venture-based programs include
DreamIt Health accelerator and
FastForward incubator
•
Venture-based space in Science +
Technology Park at Johns Hopkins
Thank you
Helen Montag
hmontag@jhmi.edu
Appendix
What is technology transfer?
Technology transfer is the process of transferring
scientific findings from one organization to another
for the purpose of further development and
commercialization. The process typically includes:
 Identifying new technologies
 Protecting technologies through patents and copyrights
 Forming development and commercialization strategies
such as marketing and licensing to existing private
sector companies or creating new startup companies
based on the technology
What is Technology Transfer?
Reasons for University Technology Transfer
Academic and research institutions engage in
technology transfer for a variety of reasons, such as:
 Compliance with federal regulations
 Recognition for discoveries made at the institution
 Attraction and retention of talented faculty
 Local economic development
 Attraction of corporate research support
 Licensing revenue to support further research and
education
Successful Products from University
Tech Transfer
JHU Inventions by faculty
For proceeds from the licensing of an invention,
the split is:
Inventors’
Personal
Share
Inventors’
Research
Share
Inventors’
Dept
Share
School
Share
University
Share
First $300k
35%
15%
15%
30%
5%
Over $300k
35%
15%
15%
25%
10%
Survey on Technology Licensing Activities
 Rollout out June 2014
 Faculty & Licensees
• 7 of 18 responded (40%)
- 85% satisfied or very satisfied overall with their
experience
- 100% satisfied or very satisfied with their assigned
technology licensing associate
 Next wave now underway
• Agreements: 23 invitations to licensees or faculty
• ROIs: 46 invitations