Curriculum Vitae
98 Brett Road, Engineering Building C106
Piscataway, NJ 08854
Email:Haoran.Zhang@Rutgers.edu
Haoran Zhang
Assistant Professor
Department of Chemical and Biochemical Engineering
Rutgers. The State University of New Jersey
09.2015-present
Education and Training

Postdoctoral Associate
Department of Chemical Engineering, Massachusetts Institute of Technology, MA
Advisor: Gregory Stephanopoulos
2011-2015

Ph. D. in Chemical Engineering
Department of Chemical and Biological Engineering, Tufts University, MA
Advisor: Blaine Pfeifer
2005-2010

M. S. in Chemical Engineering
Department of Chemical and Biochemical Engineering, Xiamen University, China
Advisor: Qingbiao Li
2002-2005

B. S. in Chemical Engineering
Department of Chemical and Biochemical Engineering, Xiamen University, China
1998-2002
Research Interests
Metabolic Engineering, Natural Product Biosynthesis, Applied Microbiology
Selected Publications
1. Zheng-Jun Li, Kangjian Qiao, Weichao Shi, Brian Pereira, Haoran Zhang, Bradley D. Olsen, Gregory
Stephanopoulos. Biosynthesis of novel glycolate-containing polymers from glucose by metabolically
engineered Escherichia coli. Under Review.
2. Brian Pereira, Zheng-Jun Li, Marjan De Mey, Chin Giaw Lim, Haoran Zhang, Claude Hoeltgen,
Gregory Stephanopoulos. Efficient utilization of pentoses for the bioproduction of renewable twocarbon compounds, ethylene glycol and glycolate. Metabolic Engineering. Under review.
3. Haoran Zhang, Fang Lei, Blaine A. Pfeifer. The continuing development of E. coli as a heterologous
host for complex natural product. Methods in Molecular Biology. In press.
4. Brian Pereira, Haoran Zhang, Marjan De Mey, Chin Giaw Lim, Zhengjun Li, Gregory
Stephanopoulos. Engineering a novle biosynthetic pathway in Escherichia coli for production of
renewable ethylene glycol. Biotechnology and Bioengineering. In press.
Curriculum Vitae
Haoran Zhang
5. Haoran Zhang, Zhengjun Li, Brian Pereira, Gregory Stephanopoulos. Engineering E. coli-E. coli
cocultures for production of muconic acid from glycerol. Microbial Cell Factories. 2015. 14:134.
6. Haoran Zhang, Brian Pereira, Zhengjun Li, Gregory Stephanopoulos. Engineering Escherichia coli
coculture systems for the production of biochemical products. Proceedings of the National Academy of
Sciences of the United States of America. 2015. 112: 8266-8271.
7. Kangjian Qiao, Syed Abidi, Hongjuan Liu, Haoran Zhang, Sagar Chakraborty, Nicki Watson, Parayil
Kumaran Ajikumar, Gregory Stephanopoulos. Engineering lipid overproduction in the oleaginous yeast
Yarrowia lipolytica. Metabolic Engineering. 2015. 29:56-65.
8. Haoran Zhang, Gregory Stephanopoulos. Engineering E. coli for caffeic acid biosynthesis from
renewable sugars. Applied Microbiology and Biotechnology. 2013. 97(8): 3333-3341.
9.
Ming Jiang, Haoran Zhang, Sung-Hee Park, Yi Li, Blaine Pfeifer. Deoxysugar pathway interchange
for erythromycin analogues heterologously produced through E. coli. Metabolic Engineering. 2013. 20:
92-100.
10. Ming Jiang, Haoran Zhang, Blaine A. Pfeifer. The logic, experimental steps, and potential of
heterologous natural product biosynthesis featuring the complex antibiotic erythromycin A produced
through E. coli. The Journal of Visualized Experiments. 2013. (71): e4346.
11. Haoran Zhang, Karin Skalina, Ming Jiang, Blaine A. Pfeifer. Improved E. coli erythromycin A
production through the application of metabolic and bioprocess engineering. Biotechnology Progress.
2012. 28(1): 292-296.
12. Haoran Zhang, Brett A. Boghigian, John Armando, Blaine A. Pfeifer. Methods and options for the
heterologous production of complex natural products. Natural Product Reports. 2011. 28(1): 125-151.
13. Brett A. Boghigian, Haoran Zhang, Blaine A. Pfeifer. Multi-factorial engineering of heterologous
polyketide production in Escherichia coli reveals complex pathway interactions. Biotechnology and
Bioengineering. 2011. 108(6): 1360-1371.
14. Haoran Zhang, Yong Wang, Jiequn Wu, Blaine A. Pfeifer. Complete biosynthesis of erythromycin A
and designed analogs using E. coli as a heterologous host. Chemistry and Biology. 2010. 17: 1232-1240.
15. Haoran Zhang, Brett A. Boghigian, Blaine A. Pfeifer. Investigating the role of native propionyl-CoA
and methylmalonyl-CoA metabolism on heterologous polyketide production in Escherichia coli.
Biotechnology and Bioengineering. 2010. 105(3): 567-573.
16. Jiequn Wu, Brett A. Boghigian, Melissa Myint, Haoran Zhang, Blaine A. Pfeifer. Construction and
performance of heterologous polyketide producing K-12 and B-derived Escherichia coli. Letters in
Applied Microbiology. 2010. 51: 196–204.
17. Haoran Zhang, Yong Wang, Brett A. Boghigian, Blaine A. Pfeifer. Probing the heterologous
metabolism supporting 6-deoxyerythronolide B biosynthesis in Escherichia coli. Microbial
Biotechnology. 2009. 2(3): 390-394.
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Curriculum Vitae
Haoran Zhang
18. Haoran Zhang, Yong Wang, Blaine A. Pfeifer. Bacterial hosts for natural product production.
Molecular Pharmaceutics. 2008. 5(2): 212-225.
19. Haoran Zhang, Qingbiao Li, Huixuan Wang, Daohua Sun, Yinghua Lu, Ning He. Accumulation of
silver(I) ion and diamine silver complex by Aeromonas SH10 biomass. Applied Biochemistry and
Biotechnology. 2007. 143: 54-62.
20. Haoran Zhang, Qingbiao Li, Yinghua Lu, Xueping Lin, Xu Deng, Ning He, Shuzhen Zheng.
Biosorption and bioreduction of diamine silver complex by Corynebacterium. Journal of Chemical
Technology & Biotechnology. 2005. 80(3): 285-290.
21. Haoran Zhang, Qingbiao Li, Daohua Sun, Xueping Lin, Xu Deng, Yinghua Lu, Ning He. The
preparation of silver nanoparticles (in Chinese). Precious Metals. 2005. 26(2): 51-56.
Patents
1. Gregory Stephanopoulos, Kang Zhou, Kangjian Qiao, Steve Edgar, Haoran Zhang. Co-culture based
modular engineering for the biosynthesis of isoprenoidsm aromatics and aromatic-derived compounds.
World Intellectual Property Organization patent. Publication number : WO 2015069847 A2. US patent
publication nmber US 20150203880.
2. Blaine A. Pfeifer, Haoran Zhang, Sunghee Park. Genetically modified E. coli strains for producing
erythromycin analogs. World Intellectual Property Organization patent. Publication number : WO
2012/166408.
3. Blaine A. Pfeifer, Haoran Zhang. Genetically modified E. coli strains for producing erythromycin.
US patent application filed at 04/21/2010. Application number: 12/764,230
4. Qingbiao Li, Mouxing Fu, Daohua Sun, Haoran Zhang, Huixuan Wang, Lin Wang, Ning He,
Yuanpeng Wang, Cuixue Chen. A new method for preparation of water-soluble silver nanoparticles
containing biomass. Chinese patent. Filed at 2007. Chinese patent publication number: CN100500335
Conference Presentations
1. Haoran Zhang, Brian Pereira, Zhengjun Li, Gregory Stephanopoulos, Co-culture based modular
engineering for aromatic and aromatic-derived compound production in E. coli. AIChE annual
meeting. Atlanta, GA, Nov. 2014.
2. Haoran Zhang, Brian Pereira, Gregory Stephanopoulos, Co-culture based modular engineering for
aromatic and aromatic-derived compounds production in E. coli. Metabolic Engineering X, Vancouver,
Canada, Jun. 2014.
3. Haoran Zhang, Yong Wang, Jiequn Wu, Blaine A. Pfeifer. Heterologous biosynthesis of
erythromycin A and its analogs in E. coli. Society for Industrial Microbiology annual meeting. San
Francisco, CA, Aug. 2010.
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Curriculum Vitae
Haoran Zhang
4. Haoran Zhang, Brett A. Boghigian, Blaine A. Pfeifer. Engineer propionyl-CoA and (2S)methylmalonyl-CoA synthesis in E. coli to support heterologous 6-deoxyerythronolide B production.
AIChE annual meeting. Nashville, TN, Nov. 2009.
5. Haoran Zhang, Heterologous biosynthesis of lomaiviticin in Escherichia coli. Invited presentation at
Wyeth Natural Products Division. Pearl river, NY, Dec. 2008.
6. Haoran Zhang, Blaine A. Pfeifer. Heterologous perturbation on 6dEB biosynthesis in E. coli. Boston
Bacterial Meeting. Cambridge, MA, Jun. 2008.
7. Haoran Zhang, Blaine A. Pfeifer. Gene expression analysis of heterologous 6dEB biosynthesis.
AIChE annual meeting. Salt Lake City, UT, Nov. 2007.
8. Yong Wang, Brett A. Boghigian, Guangquan Shi, Haoran Zhang, Janelle Lavoie, Blaine Pfeifer.
Enhancing polyketide production in E. coli by accumulating intracellular S-adenosylmethionine.
Boston Bacterial Meeting. Boston, MA, Jun. 2007.
9. Haoran Zhang, Qingbiao Li, Daohua Sun, Xueping Lin, Xu Deng, Yinghua Lu, Ning He. Preparation
of silver nanoparticles by bioreduction using bacterium SH09. 1st Chinese National Chemical and
Biochemical Engineering Annual Meeting. Nanjing, China, Nov. 2004.
Academic Honors

Distinguished Alumnus of Chemical Engineering Department of Xiamen University, 2012

Research Grant-in-Aid Award for Graduate Student, Tufts University, 2010

Excellent Master Thesis Award, Xiamen University, 2005

Industrial and Commercial Bank of China Award for Graduate Student, Xiamen University, 2005

National Guanghua Award of China, 2005

Best Senior Student Award of Xiamen University, 2005

Bendong Prize (one of the highest honors at Xiamen University), 2005

Ziqin Award, Xiamen University, 2001

Excellent Student of Xiamen University, 2001

Wusimin Award for outstanding academic performance, Xiamen University, 2000
Professional Experience
Reviewership
 Metabolic Engineering
 Nature Communications
 Applied Microbiology and Biotechnology
 Journal of Biotechnology
 PLoS ONE
 Biomedical Research International
Professional Membership
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Curriculum Vitae
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

Haoran Zhang
American Institute of Chemical Engineers
Society for Biological Engineering
Society for Industrial Microbiology and Biotechnology
Internship
 Sinopec Shanghai Petrochemical Company Limited, China. Sep, 2001- Oct, 2001
Project: Industrial scale dehydrogenation of ethyl benzene.

Fujian Yong’an Chemical Company, China. Oct.2000-Nov.2000
Project: Industrial production process of polyvinyl chloride.
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