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AMGEN SCHOLARS PROGRAM

2009 Annual Report

Through an eight-year, $27.5 million commitment from the Amgen Foundation,

Amgen Scholars is providing undergraduate students with the opportunity to engage in hands-on science research at some of the world’s leading universities.

“For undergraduates to experience research in real laboratories early in their careers, with all the rewards and the frustrations that research brings… that is a real gift, and is tremendously important in a truly academic education. The Amgen Scholars Programme offers that gift to outstanding undergraduates across Europe and the United States, and the University of Cambridge is honoured to be part of such a unique endeavour.”

– Professor Alison Richard, Vice Chancellor, University of Cambridge

Pictured above, UC Berkeley Amgen Scholar Melissa Velasquez in Dr. Kevin Healy’s lab with postdoctoral student Jacob Pollock.

DISCOVER YOUR POTENTIAL

81

EUROPE

U.S.

2007 2008 2009

NUMBER OF COLLEGES AND UNIVERSITIES REPRESENTED

BY AMGEN SCHOLAR APPLICANTS

255

EUROPE

2007 2008 2009

NUMBER OF AMGEN SCHOLAR APPLICANTS

U.S.

323

EUROPE

“There is a single light of science, and to brighten it anywhere is to brighten it everywhere.” So wrote Isaac Asimov, one of the twentieth century’s finest science writers.

The Amgen Scholars Program was founded to ensure that today’s undergraduates have the opportunity to discover their potential to contribute to the light that science casts; three years later, it is clear that the program has been hugely successful in this aim. Those whom we have welcomed as Amgen Scholars have impressed us all with their energy and enthusiasm for science, and with the way in which they have grasped the opportunities provided through the program with both hands.

Many of the program’s alumni are already taking the first steps toward a research career of their own, winning prestigious scholarships and awards along the way. We will continue to watch with pride as the discoveries they make help to brighten the light of science across a wide range of disciplines.

On top of the continued success of the 10 U.S. program sites, the past year has been an exciting one for the Amgen Scholars Program as we welcomed the first cohort of Amgen Scholars in Europe. The addition of the Karolinska Institutet in Stockholm, Sweden; Ludwig-Maximilians-

Universität in Munich, Germany; and the University of Cambridge in the

United Kingdom as program sites has enabled us to reach many more of the potential scientific leaders of tomorrow, and provides a truly international dimension to the program. Together, all 13 sites make this a premier program around the globe.

As of late 2009, we were also excited to announce the launch of our new program website which is enabling all our Scholars, past and present, to continue to use and build on the networks they have developed during the program, and create new ones, and the internationality of our alumni can only help in that regard.

We expect that the incoming year will be another exciting one for the program and everyone involved. As always, we endeavor to build on past successes, and to ensure that the program continues to raise the scientific aspirations of all those who participate. In 2010, we look forward to welcoming another group of exceptional young scientists as

Amgen Scholars, and to supporting them, and all our alumni, as they strive to brighten the light of science on an international scale.

U.S.

2007 2008 2009

NUMBER OF AMGEN SCHOLAR APPLICATIONS*

*NOTE: Applicants may apply to multiple Amgen Scholar host institutions.

Tony Minson

Director, Amgen Scholars

European Coordinating Center

University of Cambridge

Christopher M. Jones

Director, Amgen Scholars

U.S. Program Office

Massachusetts Institute of Technology

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HOW BIOLOGY DRIVES BIOTECHNOLOGY

Biotechnology is based on biology, which is the study of life. The basic unit of life is the cell. Biologists study the structure and functions of cells – what cells do and how they do it. Biotechnologists use this information to develop products.

Biomedical researchers use their understanding of genes, proteins and cell parts to pinpoint the differences between diseased and healthy cells. When researchers know how diseased cells are altered and when they learn how to affect those alterations, they are better able to develop innovative medical diagnostics, devices and therapies.

The biotechnology industry uses advanced technologies to apply cellular and molecular biology to create new, beneficial products. Medical biotechnology products are used to treat or prevent diseases. These products include therapeutic proteins, monoclonal antibodies, vaccines, allergy immunotherapy products, blood components, and tissues and cells for transplantation.

In addition to these biotechnology products, which have offered new treatment options to millions of patients, new, innovative diagnostics and therapies are changing how some human diseases are prevented and others are treated. This monumental healthcare shift is in its early stages, with novel medicines, diagnostics and technologies in development that hold great potential to improve patients’ lives.

The practice of medicine has changed dramatically over the years through pioneering advances in biotechnology research and innovation, and millions of patients around the globe continue to benefit from the treatments developed by companies that are discovering, developing and delivering innovative medicines to treat serious illnesses. As companies continue to develop medicines that address significant unmet needs, future innovations in biotechnology research will bring exciting new advances to help millions more people worldwide.

THE AMGEN SCHOLARS WEBSITE ADDS AN

EXCLUSIVE COMMUNITY TO BUILD A GLOBAL

NETWORK OF SCIENTISTS

Amgen Scholars will have exclusive access to the online Amgen Scholars

Community (www.amgenscholars.com), where they can keep in touch with one another, make new connections, and maintain the excitement and momentum of the program long after their summer lab experiences come to a close.

The new website, launched in partnership with The Scientist , a leading life sciences magazine, allows current Amgen Scholars and alumni to log in and access tools aimed at helping them to build professional networks and read the latest science and career news. Through the use of interactive polls, message boards, personal profiles and blogs, users can discuss their participation in the program and various science-related topics, such as graduate education and career paths in research. Others interested in the program can also view past participant and faculty mentor profiles, and read excerpts of student blogs from the online community in the publicly accessible section of the site.

Additionally, the Scholars can create their own profiles with their names and photographs, and provide updates on their current educational status.

Similar to other networking sites, the Scholars can “friend” one another, post comments on one another’s “walls,” participate in polls and communicate through instant messaging.

With over 800 students completing the Amgen Scholars Program since the first summer in 2007, this special members-only section will evolve into a close-knit global networking site where Scholars can continue to share their passion for science going forward.

On the public site, visitors will find an overview of the Amgen Scholars

Program and its objectives, a list of the 10 U.S. and three European host universities with links to their specific program descriptions and the key areas of academic research offered. They can also view past photos of the symposia where all Scholars gather to hear firsthand from leading industry and academic scientists, network with one another and discuss their summer research projects.

The site also features a special Learn About Biotechnology section that touches on biotechnology basics and historical milestones, along with sections on genes, DNA structure, the genetic code, DNA, RNA and proteins, the backbone of biotechnology, recombinant DNA – and a look toward the future.

“The new website is designed to connect, engage and inspire Amgen

Scholars on a global level by bringing together participants from diverse backgrounds and wide-ranging scientific career aspirations,” says

Christopher Jones, director, U.S. Program Office. “We hope that this site will enrich the experience for all participants – not only during their participation in the program, but throughout their careers in science.”

DID YOU KNOW:

Each year, 32 Americans are selected as Rhodes Scholars.

Since the program started in 2007, an Amgen Scholar alumnus or alumna has been named a Rhodes Scholar every year.

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A R E A S O F R E S E A R C H

Biochemistry

Bioengineering

Bioinformatics

Biopsychology

Biotechnology

Chemical & Biomolecular

Engineering

Chemistry

Immunology

Medical Pharmacology

Microbiology

Molecular, Cell &

Developmental Biology

Molecular Genetics

Molecular Medicine

Molecular Pharmacology

Neurobiology

Neuroscience

Pathology

Physiological Psychology

Physiological Science

Statistics

Toxicology

A SUMMER IN A WORLD-CLASS LAB.

A LIFETIME OF DISCOVERY.

“By 2010, we’ll have more than 1,000

Amgen Scholar alumni in the United States and Europe. Several from the first class are now pursuing PhDs and MD-PhDs at top universities, and several have received prestigious fellowships. The Amgen Scholars

Program is central to our investments in science education and one of the many ways we hope to inspire and prepare the next generation of scientists.”

– Jean Lim, President,

Amgen Foundation

Biology, biochemistry, bioengineering – these are the most popular areas of interest among the 329 undergraduates who spent the summer working under the guidance of top academic scientists in leading labs across the United States and Europe.

The students were part of a hands-on science and biotechnology research experience available only through the Amgen Scholars Program.

They arrived at their labs each morning and, for the next eight to 10 weeks, spent their days focused on scientific discovery.

Launched in October 2006, the Amgen Scholars Program offers students the chance to participate in science beyond the likely scope of their regular undergraduate education. The program offers financial support to broaden access to all students who want to participate.

In 2009, the Amgen Foundation and 13 host universities welcomed 270

U.S. students and, new this year, 59 students from across Europe, selected from 2,800 applicants. The Amgen Scholars represented over 170 colleges and universities across 39 U.S. states and 15 European countries.

The Amgen Scholars Program is proving to be pivotal in inspiring students to pursue graduate training and scientific careers. Students call the program a challenging and often life-changing experience.

UC Berkeley Amgen Scholars participate in the end-of-program poster and oral presentations.

Amgen Scholars across all 13 host universities present their research through similar events at their respective institutions.

DID YOU KNOW:

Nine Nobel Laureates have served as faculty mentors in the

Amgen Scholars Program.

CARL J. SUNDBERG, MD, PhD

ASSOCIATE PROFESSOR, KAROLINSKA INSTITUTET

As an expert in muscle physiology, Dr. Carl Johan Sundberg,

MD, PhD, of Stockholm’s Karolinska Institutet, devotes his scientific career to researching and understanding the health benefits of physical activity. The more discoveries

Dr. Sundberg and his team can make, the better they can help prevent diabetes, cardiovascular disease and more.

Their work has limited meaning, however, unless the results are widely communicated with medical practitioners and the population at large. That’s what inspired Dr. Sundberg to create the Euroscience Open Forum (ESOF). Held every two years, ESOF attracts more than 5,000 scientists, policymakers, journalists and others who come to hear and discuss new scientific findings.

One budding scientist hoping to attend the 2010 gathering in Barcelona is Maria Sobczyk. An Amgen Scholar from

Poland, Sobczyk is a biology major at the University of York in the United Kingdom.

She spent the summer in Dr. Sundberg’s lab, comparing the transcription of mitochondrial biogenesis factors in human skeletal muscle during acute and endurance exercise.

The results of her work have potential use in treating patients with type 2 diabetes, and cardiac insufficiency.

“Maria developed a strong understanding of the basic mechanisms for health, which translate into preventive or curative measures,” Dr. Sundberg says. “I hope Maria became even more excited about science – not just by experiencing how science can be done, but by seeing the direct effect it has on patients.”

Sobczyk was particularly pleased with the program, which was in its first summer at Karolinska Institutet.

“The program was a perfect way for me to see what it would be like to work full time as a scientist,” says

Sobczyk. “I learned how to be methodical and critical, how to design experiments and the appropriate times to draw conclusions. I also loved being around other students from throughout Europe.”

“Offering summer research experiences through the

Amgen Scholars Program is a new idea for Europe – and it’s a great way to bring young people into the lab,” says

Dr. Sundberg.

A professor of bioentrepreneurship as well as physiology and pharmacology at the Karolinska

Institutet in Sweden, Dr. Carl

Johan Sundberg served as a faculty mentor during the first year of the Amgen Scholars

Program in Europe.

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2009 HOST INSTITUTIONS

C A L I F O R N I A I N S T I T U T E

O F T E C H N O L O G Y

Pasadena, CA

26 Scholars from

14 Universities across

8 States

C O L U M B I A

U N I V E R S I T Y /

B A R N A R D C O L L E G E

New York, NY

29 Scholars from

12 Universities across

8 States

H O W A R D U N I V E R S I T Y

Washington, D.C.

20 Scholars from

13 Universities across

11 States

M A S S A C H U S E T T S

I N S T I T U T E O F

T E C H N O L O G Y

Cambridge, MA

27 Scholars from

16 Universities across

12 States

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U N I V E R S I T Y O F

C A L I F O R N I A ,

S A N D I E G O

San Diego, CA

30 Scholars from

16 Universities across

10 States

U N I V E R S I T Y O F

C A L I F O R N I A ,

S A N F R A N C I S C O

San Francisco, CA

29 Scholars from

27 Universities across

19 States

U N I V E R S I T Y O F

W A S H I N G T O N

Seattle, WA

29 Scholars from

22 Universities across

12 States and Puerto Rico

U N I V E R S I T Y O F

C A M B R I D G E

Cambridge, United Kingdom

25 Scholars from

15 Universities across

10 Countries

“This is an excellent program that identifies the very top undergraduate students in science across the country and presents them with an opportunity to work at the cutting edge of science. My experience as a mentor has been very fulfilling. I was given the opportunity to work with incredible minds who also possessed a lot of ambition and drive.”

– Dr. Richmond Sarpong, Assistant Professor of Chemistry, UC Berkeley

S TA N F O R D

U N I V E R S I T Y

Palo Alto, CA

30 Scholars from

27 Universities across

13 States and Puerto Rico

U N I V E R S I T Y O F

C A L I F O R N I A ,

B E R K E L E Y

Berkeley, CA

25 Scholars from

21 Universities across

14 States and Puerto Rico

U N I V E R S I T Y O F

C A L I F O R N I A ,

L O S A N G E L E S

Los Angeles, CA

25 Scholars from

12 Universities across

8 States

K A R O L I N S K A

I N S T I T U T E T *

Stockholm, Sweden

12 Scholars from

11 Universities across

9 Countries

L U D W I G - M A X I M I L I A N S -

U N I V E R S I T Ä T M U N I C H *

Munich, Germany

22 Scholars from

13 Universities across

11 Countries

* These organizations received a grant from the United Way Worldwide (UWW) in collaboration with the Amgen Foundation. The Amgen Foundation and UWW work together to support the efforts of nonprofit organizations outside of the United States.

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SCHOLAR NAME: Jose Rios

UNDERGRADUATE INSTITUTION: Arizona State University

HOST INSTITUTION: Massachusetts Institute of Technology

HOMETOWN: Phoenix, Arizona, United States

MAJOR/DEGREE OBJECTIVE: Bioengineering

Jose Ruiz in the Langer Lab with Dr. Robert Langer of MIT.

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“I knew that I liked science, but until I got that lab experience this summer, I didn’t know if I could make it a career. The Amgen Scholars Program showed me that I could.”

To know Jose Rios, you’d think higher education was always in his plans. As a top high school student with a passion for science, he had certainly considered it. But Rios knew his family couldn’t afford the added expense. It wasn’t until his physics teacher connected him with the right scholarships that Rios realized college could, indeed, become a reality.

Now a senior at Arizona State University, Rios graduates in May 2010 with a bioengineering degree – the first in his family to earn a college diploma. And, thanks to guidance from a professor familiar with the Amgen

Scholars Program, the first in his family with MIT on his curriculum vitae.

Rios spent two months in the summer of 2009 as an Amgen Scholar in the prestigious lab of MIT Professor Robert Langer. His project: Targeting

Nanocarriers to Cancer with Folic Acid.

Rios spent his days synthesizing and transforming polymers into nanoparticles to improve their ability to target the disease.

Along with discovering new science, Rios says gaining hands-on lab experience was just as valuable. Everything he learned that summer, he says, was new. He enjoyed it all – even the challenges. “Sometimes you plan your experiments, but many times they don’t go right,” Rios says. “You troubleshoot and find out what’s wrong. And then you make corrections and you’re able to get good data. That feels good.”

He also enjoyed the U.S. Symposium in Los Angeles, where Scholars from across the country gathered to meet and network with one another, share their research, and hear from industry and academic scientists.

What’s after graduation? Rios had been thinking of pursuing science further or focusing on an MBA. The Amgen Scholars Program convinced him that his heart lies in the lab. He’s planning to apply to MIT to pursue his graduate degree in bioengineering.

“I knew that I liked science, but until I got that lab experience this summer, I didn’t know if I could make it a career,” he notes. “The Amgen

Scholars Program showed me that I could.”

“I’d like my work to have meaning to society,” Rios adds. “Through research and medicine, you really can better the lives of many people in ways that you’ve never imagined.”

Since returning to Arizona, Rios has continued his work with the Society of Hispanic Professional Engineers, visiting Phoenix-area elementary and middle school classrooms to speak about his experiences in science.

His message to students, especially those first-generation Americans of

Hispanic heritage: They, too, can and should go to college.

When Taiyabah Naeem learned about the Amgen Scholars Program and the chance to work in Dr. Anthony Ricci’s Otolaryngology lab at Stanford

University, she didn’t hesitate to apply.

Her summer project of observing the time course of aminoglycosides’ pathway entry into the channels of the inner ear cells was of special interest to her. Naeem, a dual biology and chemistry major at Gallaudet

University, has been deaf since birth.

“I wanted to be part of a research group committed to helping people and learning more about how the inner ear works,” says Naeem. “Being a deaf person myself, it was intriguing to learn more about the ear and its structure and function. Knowing that our research project could possibly impact thousands of hearing-impaired people is pretty amazing.”

Aminoglycosides are antibiotics used to treat bacterial infections.

However, because they’re toxic, they can cause permanent hearing loss.

Naeem’s research supported the hypothesis that aminoglycosides enter the hair cell through MET channels, which increase the antibiotics’ toxicity. Her findings suggest that aminoglycosides should be redesigned for safer entry into the inner ear, thereby avoiding the potential for hearing impairment.

Perhaps not surprisingly, one of the most challenging aspects of the experience for Naeem was noticing what was going on around her

– especially in group meetings. Naeem found it challenging to catch signaling sounds during experiments, communicate in dark rooms and understand those who spoke softly or with heavy accents.

“There is no doubt that being deaf in the field of science is an interesting and challenging experience,” she says. “But deaf people can definitely be trained in science if we are given the opportunity and support needed to succeed. Sometimes I think that being deaf works to my advantage because it hones my other senses, such as vision and smell.”

Prior to Amgen Scholars, Naeem was planning on medical school. Now she’s considering graduate-level research in hearing loss.

“Either way, I’m much more committed and prepared,” she says. “In general, I find that people are very willing to give me a chance to prove my abilities in science. Ultimately, I want to be a role model for other deaf people from varying backgrounds.”

“Being a deaf person myself, it was intriguing to learn more about the ear and its structure and function. Knowing that our research project could possibly impact thousands of hearing-impaired people is pretty amazing.”

Taiyabah Naeem in Dr. Anthony Ricci’s

Otolaryngology lab at Stanford University.

SCHOLAR NAME: Taiyabah Naeem

UNDERGRADUATE INSTITUTION: Gallaudet University

HOST INSTITUTION: Stanford University

HOMETOWN: Toronto, Canada

MAJOR/DEGREE OBJECTIVE: Biology and Chemistry

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SCHOLAR NAME: Sophie Thomain

UNDERGRADUATE INSTITUTION: École Normale Supérieure

HOST INSTITUTION: University of Cambridge

HOMETOWN: Bidos, France

MAJOR/DEGREE OBJECTIVE: Bioengineering

Sophie Thomain in the Krude Lab with Dr.

Torsten Krude of the University of Cambridge.

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“I enjoyed being together in the same place and sharing our difficulties, doubts and successes. We learned how to communicate our results – and our lack of results!

It’s more than a lab experience. It’s a human experience.”

As a third-year biology student at the prestigious École Normale

Supérieure in Paris, Sophie Thomain knew she was getting an excellent education, but she wanted to round out her undergraduate experience with extra lab work. She’d heard about the groundbreaking discoveries in Dr. Torsten Krude’s lab at the University of Cambridge, so she inquired about an internship.

Dr. Krude suggested something even better: the Amgen Scholars Program, which would provide support to assist with Thomain’s travel and living expenses and include a stipend, thus freeing her from financial worries over the summer.

“When he told me about the program, I couldn’t believe my luck,” Thomain says. “I immediately applied and couldn’t wait to get started.”

Thomain spent the summer in Dr. Krude’s lab, researching how DNA is replicated in human cells. She focused on a small RNA named hY RNA, which Dr. Krude’s team had discovered years earlier. Her task: to understand the role hY RNA plays in initiating DNA replication.

“Having a better understanding of this replication is important,” Thomain says. “If the replication is not done correctly, a cell can become cancerous.

This research is crucial in understanding carcinogenesis.”

By the end of the summer, Thomain and her team were able to show that a cell’s sensitivity to hY RNA is at the level of origin itself, and not at the global level. “That’s very fundamental research, but all knowledge is important in understanding DNA replication,” she says.

For Thomain, the Amgen Scholars Program offered far more than valuable lab lessons. It allowed her to collaborate with colleagues during a threeday symposium in which all Amgen Scholars across Europe participated.

“We acquire experience not only from the experiments in test tubes, but also from working together as a scientific community,” Thomain says. “I enjoyed being together in the same place and sharing our difficulties, doubts and successes. We learned how to communicate our results – and our lack of results! It’s more than a lab experience. It’s a human experience.”

Did the program make a difference in her career plans? Thomain shares an enthusiastic yes.

“I definitely want to spend more time in the laboratory because I like designing my own experiments – and I really enjoy working in a team,” she says. “The Amgen Scholars Program has inspired me to keep pursuing my studies right through to my PhD, and even beyond.”

When Taylor Lenton learned that Dr. John D. Roberts was accepting

Amgen Scholars to his California Institute of Technology (Caltech) lab, she knew right away where she wanted to spend her 2007 summer break.

Then a junior chemistry major at Wellesley College, Lenton identified

Caltech as one of her top graduate school choices. She had heard of Dr.

Roberts’ groundbreaking work with nuclear magnetic resonance (NMR) spectroscopy, and was attracted to the unique information that could be gained from this type of research.

“The possible applications for the research piqued my interest, and definitely motivated me to try something new,” says Lenton. “Plus, I wanted to spend some time at Caltech to make sure it was the right place for me to continue my education.”

Lenton certainly got her chance to do both. She spent 10 weeks in

Dr. Roberts’ lab suspending samples of ß-alanine, a small molecule, in different solutions and using the NMR to observe how the molecule’s movement was changed.

After graduating from Wellesley in 2008, Lenton returned to Caltech in the fall as a graduate student, just as she’d planned. She now works in Dr. John Bercaw’s lab, specializing in organometallics – a field that combines aspects of inorganic and organic chemistry. There she works on designing new metal-based catalysts for making polypropylene.

She often stops by Dr. Roberts’ lab to see how the project is going.

“Science only progresses so quickly,” Lenton says. “And often, you’ll pursue one direction only to find that you need to approach things differently.

But that’s what I love about it. As soon as you solve one piece of the puzzle, you end up facing 15 other pieces. The more approaches that you can think about and pursue, the better your ultimate result will be.”

“I still run into the Amgen Scholars I worked with that summer, as well as others who’ve been through the program at different sites. There’s an instant connection because we’re all really excited about science. It’s a great program. I’d recommend it to anyone,” Lenton says.

“I still run into the Amgen Scholars I worked with that summer, as well as others who’ve been through the program at different sites. There’s an instant connection because we’re all really excited about science.”

Taylor Lenton in Dr. John Bercaw’s lab at

Caltech where she works as a PhD student.

SCHOLAR NAME: Taylor Lenton

UNDERGRADUATE INSTITUTION: Wellesley College

HOST INSTITUTION: California Institute of Technology

GRADUATE INSTITUTION: California Institute of Technology

DEGREE PROGRAM: PhD, Chemistry

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DID YOU KNOW:

Over 70% of Amgen Scholar alumni who have completed their undergraduate studies are now pursuing an advanced degree or a career in science or engineering.

CURRENT STATUS* OF THE 378 PROGRAM ALUMNI

WHO HAVE COMPLETED THEIR UNDERGRADUATE STUDIES

53

67

UNKNOWN

(18%)

SCIENCE-

BASED

CAREER

(14%)

54

MEDICAL

SCHOOL

(14%)

25 NON-SCIENCE GRADUATE

SCHOOL/CAREER (7%)

163

GRADUATE

SCHOOL IN

SCIENCE

(MASTER,

PhD)

(43%)

16 MD/PhD

PROGRAM (4%)

STUDENTS IN PhD/MASTER

PROGRAMS BY DISCIPLINE

6% BIOCHEMISTRY

13%

6%

BIOENGINEERING

BIOLOGY

5%

11%

BIOMEDICAL SCIENCE

CHEMISTRY

5% ENGINEERING

3%

9%

IMMUNOLOGY

MOLECULAR BIOLOGY

5% NEUROSCIENCE

4%

33%

PHARMACEUTICALS

SCIENCE (UNSPECIFIED)

NOTABLE ALUMNI ACHIEVEMENTS

JOYCE HWANG

HENRY RICHARDSON LABOUISSE ’26 PRIZE RECIPIENT

Host: University of Washington, 2007

Undergraduate: Princeton University

Current: Studying drug-resistant malaria in Thailand

JENNIFER YEH

CO-AUTHOR OF ARTICLE IN NATURE ON HOW MULTI-

GENETIC EVENTS COLLABORATIVELY CONTRIBUTE TO

PTEN-NULL LEUKAEMIA STEM-CELL FORMATION

Host: University of California, Los Angeles, 2007

Undergraduate: Massachusetts Institute of Technology

Graduate: George Washington University

MICHAEL FUNK

COMPLETED FELLOWSHIP AT MAX PLANCK INSTITUTE

FOR BIOPHYSICAL CHEMISTRY IN GERMANY

Host: California Institute of Technology, 2007

Undergraduate: Vanderbilt University

Graduate: Massachusetts Institute of Technology

TIMOTHY PARENTEAU

COMPLETED INTERNSHIP AS A TRANSLATIONAL

RESEARCH ASSISTANT AT THE MAYO CLINIC

Host: Stanford University, 2007

Undergraduate: California State University, Fullerton

Graduate: University of California, San Francisco

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*Status as of Fall 2009. Note that 436 of the program’s 814 alumni are still pursuing their undergraduate studies and are not included in the pie chart above.

PARTICIPATION IN EUROPE BY UNDERGRADUATE AREA OF STUDY

OTHER (14%)

NATURAL

SCIENCE

(32%)

BIOLOGY

(22%)

* Total may exceed 100% as some participants identified more than one area of study.

MEDICAL SCIENCE (5%)

NEUROSCIENCE (5%)

PHYSIOLOGY (5%)

BIOTECHNOLOGY

(7%)

BIOCHEMISTRY

(8%)

BIOMEDICAL

SCIENCE (8%)

1

FINLAND

1

SWEDEN

KAROLINSKA INSTITUTET

SWEDEN

2

IRELAND

25

UNITED

KINGDOM

UNIVERSITY OF CAMBRIDGE

UNITED KINGDOM

3

SPAIN

2

GERMANY

6

POLAND

4

FRANCE

1

SWITZERLAND

LUDWIG-MAXIMILIANS-UNIVERSITÄT MUNICH

GERMANY

2

CROATIA 1

BOSNIA &

HERZEGOVINA

1

GREECE

2

SERBIA

7

TURKEY

1

RUSSIA

“Our goal is for this program to be a pivotal experience in the academic life of an undergraduate, exposing students to world-class research and inspiring them to pursue scientific careers.” – Scott Heimlich, Senior Program Officer, Amgen Foundation

LIST OF 2009 EUROPEAN PARTICIPANTS’ HOME INSTITUTIONS

BOSNIA

International University of Sarajevo

CROATIA

University of Zagreb

FINLAND

University of Helsinki

FRANCE

École Normale Supérieure

University of Paris VI,

Pierre et Marie Curie

GERMANY

Jacobs University Bremen

GREECE

University of Athens

IRELAND

University College Cork

University College Dublin

POLAND

Jagiellonian University

Medical University of Gdansk

Poznan University of

Medical Sciences

University of Warsaw

RUSSIA

St. Petersburg State University

SERBIA

University of Belgrade

SPAIN

Universidad Autónoma de Barcelona

Universidad Autónoma de Madrid

University of Seville

SWEDEN

Karolinska Institutet

SWITZERLAND

Swiss Federal Institute

of Technology, Lausanne

TURKEY

Bilkent University

Bogaziçi University

Fatih University

Izmir Institute of Technology

UNITED KINGDOM

Durham University

Edinburgh University

Imperial College London

King’s College London

Queen Margaret University, Edinburgh

University College London

University of Cambridge

University of Glasgow

University of Nottingham

University of Oxford

University of Sussex

University of York

*Map is based on the 2009 European participants’ home institutions.

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UNIVERSITY OF

WASHINGTON

13

WA

1

MT

2

OR

6

MN

2

ID

2

WY

2

IA

UC SAN FRANCISCO

UC BERKELEY

STANFORD

CALTECH

UC LOS ANGELES

UC SAN DIEGO

70

CA

3

UT

2

CO

2

MO

1

AZ

2

NM

1

OK

3

LA

7

TX

DID YOU KNOW:

The 814 Amgen Scholar alumni represent 269 colleges and universities across

45 U.S. states and 15 European countries.

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LIST OF 2009 U.S. PARTICIPANTS’ HOME INSTITUTIONS

AL

Stillman College

University of Alabama at Birmingham

AZ

Arizona State University

CA

California Institute of Technology

California State University, Los Angeles

California State University,

Monterey Bay

California State University, Northridge

Chapman University

Occidental College

Pitzer College

San Diego State University

Scripps College

University of California, Berkeley

University of California, Davis

University of California, Irvine

University of California, Los Angeles

University of California, Riverside

University of California, San Diego

University of California, Santa Barbara

University of California, Santa Cruz

University of Southern California

CO

University of Colorado, Boulder

Western State College of Colorado

CT

Yale University

DC

Gallaudet University

Howard University

DE

University of Delaware

FL

Barry University

Florida International University

Florida State University

University of Florida

University of South Florida

GA

Emory University

Morehouse College

Spelman College

University of Georgia

IA

Iowa State University

University of Iowa

ID

College of Idaho

University of Idaho

IL

Knox College

Loyola University, Chicago

University of Chicago

University of Illinois, Chicago

University of Illinois,

Urbana-Champaign

IN

Goshen College

KY

Transylvania University

University of Kentucky

LA

Louisiana State University

Tulane University

Xavier University of Louisiana

NOTE: All data for the Amgen Scholars Program is collected and evaluated externally through the Center for Evaluation and Education Policy (CEEP) at Indiana University.

2

WI

5

IL

2

MS

PARTICIPATION IN THE U.S. BY UNDERGRADUATE AREA OF STUDY

OTHER

(25%)

1

IN

2

AL

6

MI

10

OH

2

PA

1

VA

9

MD

29

NY

9

DC

3

NJ

1

DE

1

CT

29

MA

1

NH

5

RI

MASSACHUSETTS

INSTITUTE OF

TECHNOLOGY

COLUMBIA UNIVERSITY

HOWARD UNIVERSITY

BIOLOGY

(42%)

BIOCHEMICAL ENGINEERING/

CHEMICAL ENGINEERING (6%)

NEUROSCIENCE AND BEHAVIOR (7%)

CHEMISTRY (11%)

BIOENGINEERING/BIOMEDICAL ENGINEERING (13%)

BIOCHEMISTRY (15%)

* Total may exceed 100% as some participants identified more than one area of study.

2

TN

3

KY

5

GA

2

SC

10

FL

5

NC

6

PR

MA

Amherst College

College of the Holy Cross

Franklin W. Olin College of Engineering

Massachusetts Institute of Technology

Mount Holyoke College

Smith College

University of Massachusetts, Amherst

Williams College

MD

McDaniel College

Prince George Community College

Saint Mary’s College of Maryland

University of Maryland,

Baltimore County

University of Maryland, College Park

MI

Kalamazoo College

Michigan State University

Michigan Technological University

University of Michigan, Ann Arbor

University of Michigan, Flint

MN

Carleton College

College of Saint Scholastica

Gustavus Adolphus College

Macalester College

Minnesota State University, Mankato

University of St. Thomas, St. Paul

MO

Missouri State University

Washington University, St. Louis

MS

Alcorn State University

Tougaloo College

MT

Montana Tech of

The University of Montana

NC

Davidson College

Duke University

Elon University

University of North Carolina,

Chapel Hill

NH

University of New Hampshire

NJ

Montclair State University

Rutgers University

The College of New Jersey

NM

University of New Mexico

NY

Barnard College

Columbia University

Cornell University

Hunter College

New York University

Rensselaer Polytechnic University

Saint Joseph’s College

State University of New York, Albany

State University of New York,

Binghamton

State University of New York, Buffalo

State University of New York,

Stony Brook

Syracuse University

OH

Denison University

Kenyon College

Oberlin College

Ohio State University

Ohio University

Ohio Wesleyan University

Xavier University

OK

University of Oklahoma

OR

Oregon State University

Willamette University

PA

Temple University

University of Pennsylvania

RI

Brown University

University of Rhode Island

SC

Allen University

Benedict College

TN

Tennessee Technological University

Vanderbilt University

TX

Baylor University

Rice University

Saint Edwards University

University of Houston

University of Houston, Clear Lake

University of Texas, El Paso

UT

Brigham Young University

VA

Norfolk State University

WA

Eastern Washington University

University of Washington

Whitman College

Whitworth University

WI

Lawrence University

University of Wisconsin, Madison

WY

University of Wyoming

PUERTO RICO

University of Puerto Rico, Mayagüez

University of Puerto Rico, Río Piedras

*Map is based on the 2009 U.S. participants’ home institutions.

15

16

“I found the whole experience in Cambridge fantastic. I felt motivated and inspired by all the speakers. It has been three of the best days of my college life, so far. The program has inspired me to pursue postgraduate studies and a career in infection biology.”

“We are in a time of remarkable evolution of what is possible, and it is wondrous to imagine what is available to you.”

With those inspiring words, Joseph Miletich, Amgen’s senior vice president, Research & Development, and member, Amgen Foundation

Board of Directors, kicked off the third Amgen Scholars U.S. Symposium,

July 18–20, at UC Los Angeles. He spoke again September 16–18, at

Cambridge University, for the Amgen Scholars European Symposium.

During the three days, students share their summer research projects from top academic laboratories around the world, network with leading scientists in industry and academia, and hear presentations that aim to inspire them to pursue graduate studies and scientific careers.

At the U.S. symposium, Dr. Charles Craik, professor of biochemistry, pharmaceutical chemistry, and cellular and molecular pharmacology at

UC San Francisco, talked about various career paths open to scientists with PhDs. Amgen scientists – including Brian Kotzin, vice president of

Medical Sciences; Michael Ominsky, principal scientist in Research; and

David Reese, executive director of Global Development – highlighted the various stages of the drug discovery and development process – from identifying drug targets to the evolution of protein therapeutics. Alison

Moore, vice president of commercial manufacturing, spoke about the process of manufacturing therapeutic proteins.

Plus, more than 30 Amgen and other scientists and engineers hosted roundtable and panel discussions, giving students an insider’s view of a day in the life of a scientist. More than 40 faculty and staff from the host universities were on hand to help facilitate discussions of research projects.

A new career opportunities panel was added this year and included

Richard Gallagher, editor and publisher of The Scientist magazine. The overriding message from this panel: Consider all avenues that present themselves and try to combine your personal interests into your engagement with science.

Owen Witte, professor of microbiology, immunology and molecular genetics and director of the Eli and Edythe Broad Center of Regenerative

Medicine and Stem Cell Research at UCLA, concluded the symposium by sharing the findings of his latest cancer research – work he has advanced through a consortium of top academic researchers representing a number of disciplines.

“It’s been a fantastic experience, and I feel really lucky to have been given the opportunity.” – Deirdre Murphy, an Amgen Scholar from University College Cork in Ireland who did her summer research at the Karolinska Institutet in Sweden.

At the European Symposium in Cambridge, Scholars heard welcoming remarks from Cambridge Professor Tony Minson, director of the Amgen

Scholars European Coordinating Center, and Jean Lim, president of the

Amgen Foundation.

Students then heard keynote addresses from Amgen’s Joseph Miletich and Tom Blundell, Sir William Dunn Professor of Biochemistry at the University of Cambridge, about the impact of biotechnology on drug discovery and development from both the industry and academic perspective.

A session on practical applications of research featured speakers from both the University of Cambridge and Amgen. Another session focused on “Lives in Science” and included Ken Smith, Genzyme Professor of

Experimental Medicine, University of Cambridge; Amgen’s Ulrike Schindler, executive managing director, Research; David Dunne, professor of

Parasitology, Department of Pathology, University of Cambridge; and biotechnology entrepreneur Andy Richards.

The European Symposium also included a visit to the Wellcome Trust

Sanger Institute, one of the leading genomics centers in the world, as well as roundtable discussions and poster sessions.

PARTICIPATION BY GENDER

(U.S. AND EUROPE)

60%

FEMALE

40%

MALE

BREAKDOWN BY SUMMER RESEARCH

DISCIPLINE (U.S. AND EUROPE)

8%

7%

3%

BIOCHEMISTRY

BIOENGINEERING

CHEMICAL AND

BIOMOLECULAR ENGINEERING

7%

9%

24%

CHEMISTRY

IMMUNOLOGY

MOLECULAR, CELL AND

DEVELOPMENTAL BIOLOGY

16%

7%

3%

5%

7%

4%

MOLECULAR GENETICS

MOLECULAR PHARMACOLOGY

NEUROBIOLOGY

NEUROSCIENCE

OTHER

TOXICOLOGY

Amgen Foundation

One Amgen Center Drive

Thousand Oaks, CA 91320-1799 www.amgen.com

Massachusetts Institute of Technology

77 Massachusetts Avenue

Cambridge, MA 02139-4307 web.mit.edu

The Old Schools

Trinity Lane

Cambridge CB2 1TN, UK www.cam.ac.uk

DESIGN: Saputo Design Inc. PHOTOGRAPHY: Eileen Barroso, Steve Fisch, Warren Goebbels, Richard Harbaugh, Barry Hetherington, Andrew Houston, Timothy Llewellyn, Bob Paz, Tony Rinaldo,

Peg Skorpinski, Bob Stevens, Stefan Zimmerman WRITER: Mary Thorsby PRINTING: Universal Millennium EDITING: Linda Walsh

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