UNIVERSITY OF MALTA FACULTY OF MEDICINE & SURGERY PHARMACY DEPARTMENT MATERIAL SAFETY DATA SHEET ANHYDROUS GLUCOSE Table of Contents Ref. No. MSDS /PD/36_01 Valid for: 2 years from approval Page 1. Chemical Product 2. Composition and Information on Ingredients 3. Hazards Identification 4. First Aid Measures 5. Fire and Explosion Data 6. Accidental Release Measures 7. Handling and Storage 8. Exposure Controls/ Personal Protection 9. Physical and Chemical Properties 10. Stability and Reactivity Data 11. Toxicological Information 12. Ecological Information 13. Disposal Considerations 14. References 15. Appendices 16. Revision History Page 1 of 7 2 2 2 2 3 4 4 4 4 5 5 6 6 6 7 7 UNIVERSITY OF MALTA FACULTY OF MEDICINE & SURGERY PHARMACY DEPARTMENT MATERIAL SAFETY DATA SHEET ANHYDROUS GLUCOSE Ref. No. MSDS /PD/36_01 Valid for: 2 years from approval 1. Chemical Product Product Name: Anhydrous glucose Chemical name: alpha-D(+)-Glucose, anhydrous Synonyms: anhydrous dextrose; D-d-glucose; cartose; D-(+)-glucose; cerelose; D-(-)glucose; blood sugar; D-l-glucose; corn sugar; l-glucose; dextropur; (+)-glucose; dextrose; ()-glucose; dextrose, anhydrous; d-glucose; dextrosol; glucolin; glucose, anhydrous; glucose liquid; grape sugar; syrup. Chemical Formula: C6H12O6 2. Composition and Information on Ingredients Composition: Not Applicable Toxicological Data on Ingredients: Not Applicable 3. Hazards Identification Potential Acute Health Effects: May cause eye, digestive tract, respiratory tract and skin irritation. Potential Chronic Health Effects: CARCINOGENIC EFFECTS: Not applicable MUTAGENIC EFFECTS: Not applicable TERATOGENIC EFFECTS: Not applicable DEVELOPMENTAL TOXICITY: Not applicable 4. First Aid Measures General measures: Skin contact: Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Serious skin contact: Not Applicable Page 2 of 7 UNIVERSITY OF MALTA FACULTY OF MEDICINE & SURGERY PHARMACY DEPARTMENT MATERIAL SAFETY DATA SHEET ANHYDROUS GLUCOSE Ref. No. MSDS /PD/36_01 Valid for: 2 years from approval Eye contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Ingestion: Immediately give a glass of water. Do not induce vomiting. Serious ingestion: Not Applicable Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Serious inhalation: Not Applicable 5. Fire and Explosion Data Flammability of the Product: May be combustible at high temperature. Auto-Ignition Temperature: Not Applicable Flash points: Not Applicable Flammable limits: Not Applicable Products of Combustion: These products are carbon oxides (CO, CO2). Fire Hazards in Presence of Various Substances: Not Applicable Explosion Hazards in Presence of Various Substances: Not Applicable Fire fighting media and Instructions: In case of a small fire, use dry chemical powder, for large fire use water spray, fog or foam. Do not use water jet. Special Remarks on Fire Hazards: Not Applicable Special Remarks on Explosion Hazards: Not Applicable Page 3 of 7 UNIVERSITY OF MALTA FACULTY OF MEDICINE & SURGERY PHARMACY DEPARTMENT MATERIAL SAFETY DATA SHEET ANHYDROUS GLUCOSE Ref. No. MSDS /PD/36_01 Valid for: 2 years from approval 6. Accidental Release Measures NB: Wear appropriate protective equipment/clothing including gloves before removing any spills. Spills: Sweep up spill and wash spill area after pickup is complete. 7. Handling and Storage Precautions: Use with adequate ventilation and do not breathe dust or vapour. Avoid contact with skins, eyes, or clothing. Wash hands thoroughly after handling. Storage: Store in a cool, dry, well-ventilated, locked store room away from incompatible materials. 8. Exposure Controls/Personal Protection Airborne Exposure Limits: TWA: 300 (ppm) Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels low especially if dust, fume or mist is generated. Personal Protection: Splash goggles, full suit, boots and gloves should be worn. 9. Physical and Chemical Properties Physical state and appearance: Colourless to white crystalline solid Odour: Mild Sweet Taste: Not Applicable Molecular Weight: 180.15g pH (9% solution/water): 5.9 Boiling Point: Not applicable Melting Point: The alpha form has a melting point of 146 °C, the beta form has a melting point of 150 °C. Critical Temperature: Not Applicable Specific Gravity (Water = 1): 1.5620 at 18oC Vapour Pressure (mmHg): Not Applicable Vapour Density: Not Applicable Volatility: Not Applicable Odour Threshold: Not Applicable Page 4 of 7 UNIVERSITY OF MALTA FACULTY OF MEDICINE & SURGERY PHARMACY DEPARTMENT MATERIAL SAFETY DATA SHEET ANHYDROUS GLUCOSE Ref. No. MSDS /PD/36_01 Valid for: 2 years from approval Water/Oil Distribution Coefficient: Not Applicable Ionicity (in Water): Not Applicable Dispersion Properties: Not Applicable Solubility: Soluble in water, slightly soluble in alcohol. 10. Stability and Reactivity Data Stability: Stable under normal temperatures and pressures. Corrosivity: Non-corrosive in presence of glass. Instability temperature: Not Applicable Conditions of Instability: Incompatible materials, dust generation, excess heat and moisture. Incompatibles: Strong oxidising agents, strong acids, halogenated agents, nitrates, permanganates. Polymerization: Not applicable 11. Toxicological Information Toxicity to animals: Intraperitoneal (mouse) LD50: 18000 mg/kg Intravenous (mouse) LD50: 9000 mg/kg Effects on humans: Acute potential health effects: Eyes: Redness, tearing, itching, burning, conjunctivitis Skin: Redness, itching Ingestion: Irritation and burning sensations of mouth and throat, nausea, vomiting and abdominal pain Inhalation: Irritation of mucous membranes, coughing, wheezing, shortness of breath Chronic potential health effects: MUTAGENIC EFFECTS: Not applicable TERATOGENIC EFFECTS: Not applicable DEVELOPMENTAL TOXICITY: May cause changes in lung function i.e. pneumoconiosis Page 5 of 7 UNIVERSITY OF MALTA FACULTY OF MEDICINE & SURGERY PHARMACY DEPARTMENT MATERIAL SAFETY DATA SHEET ANHYDROUS GLUCOSE Ref. No. MSDS /PD/36_01 Valid for: 2 years from approval Other information: Not Applicable 12. Ecological Information Ecotoxicity: Not considered an environmental hazard 13. Disposal Considerations Waste Disposal: What is not recycled must be handled as hazardous waste and sent to an approved incinerator or disposed in an approved waste facility. Dissolve in water and discard with non-hazardous waste. 14. References - ScienceLab.com. Material Safety Data Sheet; Dextrose Anhydrous. [online]. 2013 [cited 2014 Jan 8]. Available from: URL: https://www.sciencelab.com/msds.php?msdsId=9927509 - ScholAR Chemistry. Material Safety Data Sheet; Glucose Anhydrous. [online]. 2009 [cited 2014 Jan 8]. Available from: URL: http://www.btps.ca/files/PDF/MSDS/Glucose_Anhydrous_308.00.pdf - Fisher Scientific. Material Safety Data Sheet; Dextrose Anhydrous. [online]. 2007 [cited 2014 Jan 8]. Available from: URL: http://faculty.uscupstate.edu/labmanager/MSDS%20files/1842%20-%20d-(+)-glucose.pdf - Arcos Organics. Material Safety Data Sheet; alpha-D(+)-Glucose, anhydrous. [online]. 2009 [cited 2014 Jan 8]. Available from: URL: http://www.westliberty.edu/healthand-safety/files/2012/08/alpha-D-Glucose_anhydrous.pdf Page 6 of 7 UNIVERSITY OF MALTA FACULTY OF MEDICINE & SURGERY PHARMACY DEPARTMENT MATERIAL SAFETY DATA SHEET ANHYDROUS GLUCOSE Ref. No. MSDS /PD/36_01 Valid for: 2 years from approval 15. Appendices Not applicable 16. Revision History Version Number Amendments/ Reasons for change 01 Initial Release Page 7 of 7