LEEDS METROPOLITAN UNIVERSITY FACULTY OF HEALTH . SCHOOL OF HEALTH SCIENCES COURSE: BSc (Hons) DATE: Monday 28th June EXAMINATION TIME: 14.00 – 16.00 (2 hours) LEVEL: One EXAMINERS: Dr Ghazala Tabasam Dr Margarita Gomez Escalada CRN 3663 TITLE OF EXAMINATION: Health Sciences 1 RESIT .................................................................................................................................. Notes for candidates: Answer ALL questions. Instructions You are required to SELECT the MOST APPROPRIATE answer for each question and to CIRCLE the appropriate letter on this book. You must CIRCLE ONLY ONE ANSWER PER QUESTION. 1. ATTEMPT ALL QUESTIONS 2. READ EACH QUESTION CAREFULLY .................................................................................................................................. PLEASE INSERT YOUR STUDENT ID NUMBER AND COURSE BELOW YOU MUST HAND IN THIS EXAM SCRIPT AT THE END OF THE EXAMINATION Candidate number:.............................................................. Course: BSc (Hons) Nursing .................................................. You are required to SELECT the MOST APPROPRIATE answer for each question and to CIRCLE the appropriate letter in this book. You must CIRCLE ONLY ONE ANSWER PER QUESTION. Your answers should also be recorded on an optical mark reader score sheet (EDPAC - pink form) as follows; Using an HB PENCIL strike through the letter (A,B,C, D or E) that indicates the answer you think is correct as shown below: [ A] [ B] [C] Do NOT mark any part of the form like this [D] [ A] or [ E] [ A] or [ A] If you wish to change an answer use a pencil eraser to completely remove the incorrect mark. It is important that you do not "dirty" the score sheet with stray marks. DO NOT FOLD THE SCORE SHEET. To add your personal details to the EDPAC (pink) form 1. Insert the letters of your surname into the Candidate name box and strike out the corresponding letters (A, B, C, D or E) in the column below 2. Insert your student id into the Candidate number box and strike out the corresponding numbers. 3. Insert the Subject code 001 into the Subject number box and strike out the corresponding numbers (001) in the column below -all candidates have the same subject code 4. Write the name of your degree course (e.g. Human Biology) into the Subject box. 5. An example of a completed EDPAC sheet is provided at the end of this paper. 60 marks Attempt to answer ALL questions. REMEMBER: SELECT the MOST APPROPRIATE answer for each question INSTRUCTIONS Choose the ONE alternative that best completes the statement or answers the question. CIRCLE the appropriate letter on this sheet. REMEMBER TO TRANSFER YOUR ANSWERS TO THE OPTICAL MARK READER SHEET (THE PINK EDPAC SHEET) 1. The correct sequence for a reflex arc is: 1 = post-ganglionic neuron, 2 = receptor, 3 = effector, 4 = control center, 5 = afferent neuron, 6 = preganglionic neuron A) B) C) D) E) 2. If a response increases the original stimulus, the system is classified as a ___________ feedback system A) B) C) D) E) 3. positive polarised negated neutral negative Which of the following is paired CORRECTLY? A) B) C) D) E) 4. 2, 5, 4, 1, 3, 6 1, 5, 4, 2, 6, 3 5, 1, 3, 2, 4, 6 2, 5, 4, 6, 1, 3 2, 5, 3, 1, 6, 4 thermoreceptors – help to produce taste chemoreceptors - detect blood pressure mechanoreceptors – help to detect blood pressure photoreceptors – help to produce photons nociceptors – detect tissue damage Which of the following is TRUE? A) B) C) D) E) there is 2 pairs of coccygeal spinal nerves there are 8 pairs of cervical spinal nerves there are 3 pairs of sacral spinal nerves there are 10 pairs of thoracic spinal nerves there are 8 pairs of lumbar spinal nerves 5. The most important factors that determine the speed of nerve impulse propagation are: A) B) C) D) E) the number of dendrites and the presence or absence of the myelin sheath fiber diameter and presence or absence of myelin sheath the strength of the stimulus and the potassium level present in the axon the level of the spinal cord nerve and the nerve fiber's diameter the strength of the stimulus and the sodium level present 6. The integrating centre which controls a feedback loop is typically sited within the: A) B) C) D) E) 7. nervous system endocrine system cardiovascular system respiratory system gastrointestinal system Which of the following statements is FALSE? A) electrical inhibition of a cell membrane is termed hyperpolarisation B) stimulus intensity is coded by the frequency of action potentials C) a travelling action potential is called an impulse D) fibers with larger diameters conduct impulses slower than fibers with smaller diameters E) myelinated fibers conduct impulses faster than unmyelinated fibers 8. Which of the following is NOT a neurotransmitter? A) B) C) D) E) dendriton gamma amino butyric acid serotonin acetylcholine dopamine 9. Which of the following is true regarding neurotransmitters? A) neurotransmitters are released by glands and transported in the blood to their target tissue B) excitatory neurotransmitters activate the post synaptic neuron by travelling through ionic channels C) neurotransmitters can be washed away from the synaptic cleft by the blood D) neurotransmitters can be actively transported back into the neuron that released them E) neurotransmitters remain in the synaptic cleft for many weeks 10. Which of the following is characteristic of the parasympathetic nervous system? A) B) C) D) E) heart rate increases liver stores glucose bronchioles dilate pupils dilate blood pressure increases 11. Which of the following are characteristic of synaptic function? A) The synapse is the functional unit of integration in the nervous system B) Action potentials can be transmitted in either direction at a synapse C) Excitatory post synaptic potentials (EPSPs) cannot undergo spatial summation because during EPSP the membrane is absolutely refractory to a second stimulus D) Release of an inhibitory transmitter agent from a presynaptic terminal will lead to a depolarization of the postsynaptic cell membrane F) Inhibitory postsynaptic potentials (IPSPs) stimulate the release of excitatory transmitter agents from presynaptic terminals 12. The output part of the autonomic nervous system has two principal divisions: A) B) C) D) E) 13. Which two systems regulate the homeostatic responses of the body? A) B) C) D) E) 14. central nervous system and peripheral nervous system preganglionic afferent nerves and postganglionic efferent nerves sensory and motor sympathetic and parasympathetic spinal nerves and cranial nerves digestive and urinary reproductive and endocrine cardiovascular and respiratory endocrine and nervous skeletal and muscular The withdrawal reflex: A) B) C) D) E) usually has noise as the stimulus is operated by the autonomic nervous system involves extension of a limb is carefully thought out is an example of an ipsilateral reflex 15. Heart rate is predominantly monitored and regulated in the: A) B) C) D) E) 16. Which of the following is considered to be the pacemaker of the heart? A) B) C) D) E) 17. P QRS T PQ SA As a result of ventricular relaxation, there is a force in which blood pushes against arterial walls. This force is called: A) B) C) D) E) 20. monocytes leukocytes lymphocytes erythrocytes thrombocytes Depolarisation of the ventricles causes which wave of the electrocardiograph? A) B) C) D) E) 19. sinoarterial fibers the bundle of his atrioventricular valve atrioventricular node sinoatrial node Which cell type lack a nucleus, cannot reproduce and consist of a "Biconcave disk shape" that is only 7.5µm wide? A) B) C) D) E) 18. medulla respiratory centre pons thalamus spinal cord systolic blood pressure pulmonary blood pressure diastolic blood pressure venous pressure synaptic blood pressure Haemopoiesis may be best described as: A) B) C) D) E) filtering of the blood cells the examination of erythrocytes plasma separation formation of blood cells blood cell mitosis 21. The type of circulation that carries blood from the lungs to the heart is referred to as: A) B) C) D) E) 22. systemic circulation systematic circulation respiratory circulation pulmonary circulation hepatic portal circulation Which blood cells are formed from fragmentation of metamegakaryocytes? A) B) C) D) E) 23. White blood cells constitute about ________ of the blood volume. A) B) C) D) E) 24. epicardium endocardium myocardium myocardial cortex visceral pericardium The delay in spread of the cardiac action potential from the atria to the ventricles is imposed by the: A) B) C) D) E) 26. 1% 80% 25% 45% 60% The outermost layer of the heart is called the : A) B) C) D) E) 25. lymphocytes monocytes thrombocytes eosinophils erythrocytes atrioventricular node sinoatrial node septum purkinje fibres bundle of His Blood pressure is usually measured in the left brachial artery using a(n): A) B) C) D) E) sphygmomanometer stethomanometer spectromanometer electrocardiograph electroechograph 27. Interstitial or tissue fluid: A) B) C) D) E) floods out from arterioles when sphincter muscle fibres contract is supplied by the liver is formed by ultrafiltration in the kidneys is found inside cells emerges largely from the arterial end of capillary beds and bathes cells 28. Pulmonary ventilation may be best defined as the: A) B) C) D) E) taking of air in through the nose exchange of gases between the atmosphere, blood and cells exchange of gases between the lungs and the atmosphere taking oxygen into and out of the blood exchange of gases between the alveoli and the blood 29. The principal inspiratory muscles are: A) B) C) D) E) external intercostals and the diaphragm pleural muscles and the diaphragm diaphragm and the thoracic wall internal intercostals and the thoracic wall internal intercostals and the diaphragm 30. Air moves out of the lungs when the pressure inside the lungs is: A) B) C) D) E) less than the pressure in the atmosphere greater than the pressure in the atmosphere equal to the pressure in the atmosphere less than intrapulmonic pressure greater than intraalveolar pressure 31. Which stimuli predominantly drive the desire to breathe? A) B) C) increase in sodium and potassium ions in the blood increase in partial pressure of oxygen and carbon dioxide build up of oxygen in the body and increase in hydrogen ions D) build up of potassium ions in the blood E) increase in partial pressure of carbon dioxide and build up of hydrogen ions 32. A part of the nervous system that coordinates the transition between inspiration and expiration by sending impulses to the inspiratory area that activates it and prolongs inspiration, thus inhibiting expiration is called: A) B) C) D) E) the medullary rhythmicity area – inspiratory area the apneustic area in the pons the pneumotaxic area in the pons the vomitting centre the medullary rhythmicity area – expiratory area 33. A respiratory disorder, whereby the airways OCCASIONALLY narrow, producing difficulty in breathing, coughing and wheezing is known as: A) B) C) D) E) 34. Which of the following is NOT a feature of the small intestine which aids in the absorption of nutrients from the gut: A) B) C) D) E) 35. E) regulation of blood pressure regulation of blood ionic composition regulation of blood pH removal of metabolic waste products (with the exception of carbon dioxide) from the body removal of old red blood cells from the circulation The correct order for the flow of filtrate through the kidney tubule is: A) B) C) C) D) 37. large surface area possession of a lacteal for fat absorption good blood supply very thick membrane all of the above are features the aid absorption Functions of the kidney include all of the following except: A) B) C) D) 36. Emphysema Chronic bronchitis Asthma Pulmonary oedema Sarcoidosis bowmans capsule, loop of henle, proximal convoluted tubule, distal convoluted tubule, collecting duct bowmans capsule, distal convoluted tubule, loop of henle, distal convoluted tubule, collecting duct bowmans capsule, proximal convoluted tubule, distal convoluted tubule, collecting duct, loop of henle bowmans capsule, proximal convoluted tubule, loop of henle, distal convoluted tubule, collecting duct bowmans capsule, proximal convoluted tubule, collecting duct, distal convoluted tubule, loop of henle Which of the following is true about antidiuretic hormone (ADH)? A) its target organ is the heart. B) alcohol stimulates ADH secretion. C) ADH is released during dehydration and it closes water channels in the collecting duct of the nephron D) it is also called vasopressin. E) the secretion of ADH increases when you drink 1 litre of water. 38. Water reabsorption in the kidney: A) B) C) D) E) 39. Nerve impulses from the hypothalamus directly stimulate release of hormones from the: A) B) C) D) E) 40. slow down chemical reactions in the gastrointestinal tract slow down gastrointestinal tract motility speed up gastrointestinal tract motility speed up chemical reactions in the gastrointestinal tract both answers C and D are correct Which of the following is NOT a process that is important in normal kidney function? A) B) C) D) E) 43. cardiovascular endocrine gastrointestinal urinary respiratory Digestive enzymes; A) B) C) D) E) 42. anterior pituitary gland only posterior pituitary gland only thyroid gland adrenal cortex both the anterior and posterior pituitary gland Which system is composed of a series of glands that secrete hormones. A) B) C) D) E) 41. is linked to the reabsorption of solutes from the filtrate does not involve aquaporins is a primary active transport process is 100% facultative (regulated) is under the control of the hormone oxytocin tubular reabsorption tubular reorganization glomerular filtration tubular secretion None of the above Which of the following substances would be expected in the urine of a healthy individual? A) B) C) D) E) Microbes Red blood cells Albumin Creatine Glucose 44. Pain can best be defined as: A) B) C) D) E) 45. Nociceptors: A) B) C) D) E) 46. A sensory experience that is ALWAYS produced by tissue damage A sensation that produces a withdrawal (flexor) reflex An emotional experience associated with unpleasant situation An unpleasant sensory and emotional experience associated with tissue damage None of the above are preferentially sensitive to stimuli which produce tissue damage when activated don’t produce a sensation of pain are preferentially sensitive to mechanical stimuli are preferentially sensitive to non-noxious stimuli are preferentially sensitive to thermal stimuli A sensation of pain involves: A) a sensory dimension B) an affective dimension C) a cognitive dimension D) all of the above E) none of the above 47. The two tracts involved in the transmission of noxious information are: A) B) C) D) E) 48. Homeostasis refers to the:A) B) C) D) E) 49. reticulospinal and thalamospinal spinothalamic and corticospinal corticospinal and thalamospinal spinothalamic and spinoreticular corticospinal and spinoreticular stoppage of bleeding formation of blood cells maintenance of the body maintenance of blood cells constant conditions in the internal environment of the body Which of the following processes utilizes a positive feedback loop? A) B) C) D) E) Child Birth Regulation of body temperature Regulation of blood pressure Regulation of blood pH All of the above 50. The alternate expansion and recoil of elastic arteries after each systole of the left ventricle creates a pressure wave that travels through the arteries that is called the: A) B) C) D) E) sounds pulse velocity wave impulse circulation time 51. Bacteria, viruses, fungi, protozoa and algae can be grouped together because: A) B) C) D) E) 52. Which of the following statements is TRUE about prokaryotic cells? A) B) C) D) E) 53. D) E) it is a unique structure of bacteria it is composed of peptidoglycan depending on the Gram reaction, they can be Gram positive or Gram negative it gives the cells rigidity it is highly impermeable and does not allow chemicals or water to pass through In which of the following body sites you wouldn’t find commensal flora? A) B) C) D) E) 55. they have complex cell structures their cells have organelles the nucleus is not surrounded by a nuclear membrane they are much larger than eukaryotic cells they are found in big groups forming complex tissues Which of the following statements regarding the bacterial cell wall is FALSE? A) B) C) 54. they have similar cellular structures they are all related they are all prokaryotes they are all small in size they are all found in similar ecosystems skin liver nose large intestine upper respiratory tract Which of the following in NOT a weapon used by microorganisms to invade our body: A) B) C) D) E) toxins enzymes the ability to attach to specific sites antibodies strength of numbers 56. Which of the following is NOT a vector for disease transmission? A) B) C) D) E) 57. Which of these statements is TRUE regarding venereal transmission of infection? A) B) C) D) E) 58. respiratory foot to mouth salivary faecal-oral venereal Which of the following is NOT part of the first line of defense against infection: A) B) C) D) E) 60. it is passed through mucosal contact the diseases that spread this way, spread very slowly it is easy to control the spread of infections transmitted this way it is not a very efficient method of transmission outside the body Which of the following is NOT a type of person to person transmission? A) B) C) D) E) 59. insects food hypodermic needle air all of the above are vectors for disease transmission lysozyme in tears flushing of urinary tract with urine phagocytes in the site of infection rapid pH change in the gastro-intestinal tract sebum on the skin Which of the following is NOT a cardinal sign of inflammation? A) B) C) D) E) rubor tumor calor redor dolor REMEMBER TO TRANSFER YOUR ANSWERS TO THE OPTICAL MARK READER SHEET (THE PINK EDPAC SHEET)