GPS Safety Summary Contacts Ethyl acetate Chemical Identity Brand names Chemical name (IUPAC) Synonyms Ethyl acetate Ethyl ethanoate Acetic acid ethyl ester; Ethyl ester; Acetic ester CAS number Molecular formula Molecular weight 141-78-6 C4H8O2 88.1 g/mol Applications Ethyl acetate is used as a solvent in coatings, inks, adhesives, and agrochemicals primarily in industry and by professional workers, but also has limited use in these applications by consumers. It is also found as a solvent in a number of consumer cosmetic products. Safety Assessment, Exposure and Risk Management Recommendations Physical and Chemical properties Property Physical state Colour Odour Boiling point Relative density Flash point Vapour pressure Water solubility Octanol water partition Health effects Result Liquid Colourless Fruity 77°C 0.9 at 20°C -4°C Volatile organic compound Very soluble Not potentially bioaccumulable Ethyl acetate is a highly flammable liquid. It is a mild eye irritant and may cause drowsiness and dizziness if inhaled in high concentrations. For industrial uses, safety measures must be respected. For more details, please refer to the Safety Data Sheet. For consumer applications, it is used in suitable concentrations according to appropriate regulations. Environmental effects Ethyl acetate is readily biodegradable and not potentially bioaccumulable. It is not classified as dangerous for the environment. Industrial emissions must comply with applicable regulations to preserve the environment. Regulatory and certification information Registration and Certification Classification and labelling EU regulation (EC) 1272/2008 (CLP) Flammable liquids, Cat.2 H225 Highly flammable liquid and vapour. Eye irritation, Cat.2 STOT single exposure, Cat.3 H319 Causes serious eye irritation. H336 May cause drowsiness or dizziness. EUH066 Repeated exposure may cause skin dryness or cracking. Warning Ethyl acetate GPS Safety Summary – Rev 0 June 2012 ISO 9001: 2008 EU regulation for chemicals (EC) 1907/2006 (REACH) Ethyl acetate is formulated to comply with requirements of most stringent regulations for applicable consumer uses. It can be safely used in suitable concentrations according to appropriate regulations. GPS Safety Summary This Product Safety Summary is intended to provide a general overview of the chemical substance in the context of ICCA Global Product Strategy. The information on the Summary is basic information and is not intended to provide emergency response information, medical information or treatment information. The summary should not be used to provide in-depth safety and health information. In-depth safety and health information can be found on the (extended) Safety Data Sheet (e)SDS for the chemical substance. Ethyl acetate General Statement This substance is classified as dangerous according to EU regulation 1272/2008. It is a highly flammable liquid. It is currently classified as an eye irritant and can cause drowsiness and dizziness if high concentrations of vapour are inhaled. It is not dangerous to the environment. Chemical Identity EC number: EC name: CAS number (EC inventory): IUPAC name: Annex I index number: Molecular formula: Molecular weight range: 205-500-4 Ethyl acetate 141-78-6 Ethyl ethanoate 607-022-00-5 C4H8O2 88.1 Uses and applications Use as a processing solvent Solvent in coatings Use in Agrochemicals Use in personal care products Use as a processing solvent for the manufacture of other chemicals. Widespread use as a solvent in solvent based coatings, adhesives and inks used in industry and by professional workers. Limited use as a solvent in coatings and adhesives used by consumers. Use in agrochemicals by professional workers and, to a limited extent consumers, where its function is as a solvent carrier for the active components. Use in cosmetics by consumers where its function is as a carrier solvent for active ingredients. Ethyl acetate GPS Safety Summary – Rev 0 June 2012 1/6 Physical/Chemical Properties Appearance/physical state/colour Melting point (@101325Pa) Boiling point (@101325Pa) Relative Density (@20C) Vapour pressure (@293K) Partition coefficient, logKow (@25 C) Solubility in water (@25 C) Surface tension (50g/l in water @20C) Flash point (@101325Pa) Autoignition temperature (@101325Pa) Dissociation constant (pKa) Viscosity (@20C) Colourless liquid, characteristic, fruity ester like odour -84C 77C 0.900 98.3hPa 0.68 80g/l Not surface active -4C 427C Not applicable 0.45mPas Health Effects Acute toxicity Irritation/corrosion Sensitisation Toxicity after repeated exposure Genotoxicity/mutagenicity Carcinogenicity Toxicity to reproduction Low order of acute toxicity. May cause drowsiness and dizziness if inhaled at high concentrations. Not irritating to the skin. May cause skin dryness or cracking due to defatting properties. Available data indicates that this substance is a mild eye irritant, but not sufficiently to warrant classification. No evidence of sensitising properties. No evidence of long term toxic effects. Not genotoxic, as shown by in vitro and in vivo experiments. Not considered carcinogenic. Based on available data, no developmental toxicity or reproductive toxicity hazard. Environmental Effects Aquatic toxicity Biodegradation Bioaccumulation potential PBT/vPvB status Slightly toxic to fish and invertebrates. Effects are not sufficient to warrant classification. Readily biodegradable. Not bioaccumulative. Not a persistent, bioaccumulative or toxic substance. Not a very persistent or very bioaccumulative substance. Ethyl acetate GPS Safety Summary – Rev 0 June 2012 2/6 Exposure Human exposure Exposure of workers in industry is controlled to levels which do not cause concern. Inhalation exposure is controlled through containment, enhanced ventilation or the use of local exhaust ventilation. Under conditions where there is high potential for dermal contact, exposure is controlled through the use of gloves. Good industrial hygiene practice means that oral exposure is negligible. Extended safety data sheets provide advice for safe use. Exposure of professional users is controlled to levels that do not cause concern. Inhalation exposure is controlled through enhanced ventilation or the use of local exhaust ventilation. Under conditions where there is high potential for dermal contact, exposure is controlled through the use of gloves. Good industrial hygiene practice means that oral exposure is negligible. Extended safety data sheets provide advice for safe use. Exposure of consumers is controlled to levels that do not cause concern. All exposures and risks are controlled by limiting the amount used in formulations (typically <25%) and/or limiting the amount of formulations sold in individual packs. Products are supplied with instructions for safe use. Environmental exposure All of the substance used by professional workers and consumers is expected to be released to the environment, primarily through evaporation of the solvent to air. The substance preferentially distributes to the air compartment. Releases to drain will be biodegraded at local sewage treatment works before release to the environment. Air emission requirements mean that most emissions from industry are destroyed by thermal oxidisers or restricted by other equivalent abatement systems before possible release to the environment can occur. Direct release to water courses is not usually permitted. Releases to water are normally degraded in local or municipal water treatment works or removed by licensed hazardous waste contractors for safe disposal. Ethyl acetate GPS Safety Summary – Rev 0 June 2012 3/6 Risk Management Recommendations Workers and consumers Workers: Use only spark-proof electrical equipment and lighting systems. Take precautions against static discharge All users: Keep away from naked flames. Keep away from ignition and heat sources. When using this substance, make sure there is adequate ventilation, natural or local exhaust ventilation. If spray applying paint, wear a respirator conforming to EN140 with Type A filter or better. Do not eat, drink or smoke where chemicals are handled, processed or stored. Wash hands and skin following contact. If the substance gets into the eyes, rinse thoroughly with tap water and seek medical attention if soreness or redness persists. If you feel unwell following inhalation exposure, seek medical attention. Read the instructions on the label or the safety data sheet. Environment All effluent releases must be directed towards a municipal or site waste water treatment plant that substantially removes the substance from the final releases to the receiving water course. All commercial waste should be disposed of using a waste operator licensed to handle hazardous waste. Industrial users and professional users of coatings should treat emissions as appropriate to comply with air emission legislation. For professional and industrial users, treat empty containers as hazardous waste. Industrial sites should have a spill plan to ensure that adequate safeguards are in place to minimize the impact of episodic releases. Bund storage facilities to prevent soil and water pollution in the event of spillage A leak prevention plan is needed to prevent low level continual releases. Consumers should dispose of old paint at municipal recycling centres. No other specific measures required for consumers. Follow any disposal advice on the product label. State Agency Review This substance has been registered under: This substance has been reviewed under the following regulatory and voluntary programmes: Ethyl acetate GPS Safety Summary – Rev 0 June 2012 EU regulation (EC) 1907/2006 (REACH) OECD HPV. US EPA IRIS 4/6 Regulatory Information / Classification and Labelling Signal word: Danger Hazard pictogram: GHS02 flame (see note 1) GHS07: exclamation mark Hazard statements H225 Highly flammable liquid and vapour. H319 Causes serious eye irritation. (See note 1) H336 May cause drowsiness and dizziness. EUH066 Repeated exposure may cause skin dryness or cracking (See note 2.) Notes 1. The harmonised classification in the EU for ethyl acetate also includes a classification for eye irritation (H319 plus GHS07) although the data now available show it is a mild irritant and it does not warrant classification for this effect. Other regulatory regimes may therefore not include this classification. 2. Classification required in the EU under the CLP regulation 1272/2008 Precautionary statements P210 Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233 Keep container tightly closed. P240 Ground/bond container and receiving equipment. P243 Take precautionary measures against static discharge. P280 Wear protective gloves/ protective clothing/ eye protection/ face protection. P303 + P361 + P353 IF ON SKIN (or hair): Remove/ Take off immediately all contaminated clothing. Rinse skin with water/ shower. P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403 + P235 Store in a well-ventilated place. Keep cool. Ethyl acetate GPS Safety Summary – Rev 0 June 2012 5/6 Conclusion Ethyl acetate is a medium to high volatility solvent from the acetate ester family of solvents. It is classified as highly flammable and as a substance that may cause drowsiness and dizziness if inhaled in high concentrations. It has no environmentally hazardous properties. It is used as a solvent in coatings, inks, adhesives, and agrochemicals primarily in industry and by professional workers, but also has limited use in these applications by consumers. It is also found as a solvent in a number of consumer cosmetic products. Contact information within company For further information on this substance or product safety summaries in general, please contact: Rhodia Global product Strategy: http://www.rhodia.com/en/sustainability/global_product_strategy/index.tcm Contact: globalproductstrategy@eu.rhodia.com Additional information ICCA Global Product Strategy: http://www.icca-chem.org/en/Home/ICCA-initiatives/global-product-strategy/ (extended) Safety Data Sheet available on demand: http://www.rhodia.com/en/contact/contact_form_business.tcm Glossary of technical terms: http://www.rhodia.com/en/sustainability/global_product_strategy/glossary/index.tcm Date of issue: June 2012 Revision: 0 Disclaimer The information provided in the present Safety Summary is based on European data available in REACH regulatory dossier (EC N°1907/2006) and is correct to the best of our knowledge, information and belief at the date of its publication. Such information is only intended to provide a general overview of the chemical substance in the context of ICCA Global Product Strategy and is not to be considered as a warranty or quality specification. It does not replace the safety data sheet and technical sheets. Thus, the information provided in this Safety Summary only relates to the designated specific product and may not be applicable if such product is used in combination with other materials or in another manufacturing process, unless otherwise specifically indicated. It does not release the user from ensuring he is in conformity with all regulations linked to its activity. Ethyl acetate GPS Safety Summary – Rev 0 June 2012 6/6