Hematology ICD-10-CM Coding Tipsheet
Overview of Key Chapter 3 Updates
Diseases of the Blood and Blood-forming Organs & Certain Disorders involving the
Immune Mechanism (D50-D89)
Key Updates to Chapter 3 of ICD-10-CM:
• Anemia is the most common condition included in this chapter. The use of specific terminology
is important in applying codes for this condition.
• Updates to medical terminology and greater specificity
• Procedural complications affecting the spleen are included in chapter 3 of ICD-10-CM.
Examples of Hematology Combination Codes – ICD-10-CM
• D57.211 – Sickle-cell/Hb-C disease with acute chest syndrome
• D57.212 – Sickle-cell/Hb-C disease with splenic sequestration
• D57.411 – Sickle-cell thalassemia with acute chest syndrome
• D57.412 – Sickle-cell thalassemia with splenic sequestration
(Source: 2014 Draft ICD-10-CM Official Guidelines for Coding and Reporting)
The top ten ICD-9 to ICD-10 mappings for this ICD-10 chapter are found in the chart below.
Top
10
ICD-9
Code
1
2
285.9
280.9
Anemia, unspecified
Iron deficiency anemia, unspecified
D64.9
D50.9
3
281.0
Pernicious anemia
D51.0
4
ICD-10
Code
ICD-9 Description
ICD-10 Description
Anemia, unspecified
Iron deficiency anemia, unspecified
Vitamin B12 deficiency anemia due to
intrinsic factor deficiency
281.1
281.1
Other vitamin B12 deficiency anemia
Other vitamin B12 deficiency anemia
D51.1
D51.2
281.1
281.1
Other vitamin B12 deficiency anemia
Other vitamin B12 deficiency anemia
D51.3
D51.8
281.1
Other vitamin B12 deficiency anemia
Other and unspecified coagulation
defects
Other and unspecified coagulation
defects
Anemia in chronic kidney disease
Thrombocytopenia, unspecified
D51.9
Vitamin B12 deficiency anemia due to
selective vitamin B12 malabsorption
with proteinuria
Transcobalamin II deficiency
Other dietary vitamin B12 deficiency
anemia
Other vitamin B12 deficiency anemias
Vitamin B12 deficiency anemia,
unspecified
D68.8
Other specified coagulation defects
D68.9
D63.1
D69.6
Coagulation defect, unspecified
Anemia in chronic kidney disease
Thrombocytopenia, unspecified
5
286.9
6
7
286.9
285.21
287.5
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The Top Ten Hematology ICD-9 to ICD-10 mappings Continued
Top
10
ICD-9
Code
ICD-10
Code
ICD-9 Description
8
288.60
Leukocytosis, unspecified
9
280.0
Iron deficiency anemia secondary to
blood loss (chronic)
10
D72.829
D50.0
ICD-10 Description
Elevated white blood cell count,
unspecified
Iron deficiency anemia secondary to
blood loss (chronic)
288.00 Neutropenia, unspecified
D70.9
Neutropenia, unspecified
The codes highlighted in orange indicate the individual ICD-9 code that is being mapped
to one or many ICD-10 codes
(Source of ICD-9-CM to ICD-10-CM mappings: CMS.org General Equivalence Mappings (GEMs), 2014)
The information in this document is not intended to impart legal advice. This overview is intended as an educational tool only and
should not be relied upon as legal or compliance advice. If you have any legal questions about the information contained herein, you
should consult your attorney or other professional legal services provider.
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