DUKE UROLOGY UPDATE I DUKE UROLOGY A Division of the Department of Surgery INSIDE: Faculty News ...... New Faculty........ Faculty Awards ... Clinical Section ... Resident Section . Research Section . Recent Significant Papers................ 2 3 3 4 5 7 8 Alumni Section ....10 Continuing Medical Education Section ...............11 Duke Urologic Assembly Symposium .........12 Fall 2013 WELCOME t has been a busy summer in Durham with the opening of the new Duke Medicine Pavilion in July. This major expansion of Duke University Hospital includes 16 operating suites and 160 critical care beds that greatly expands our ability to provide enhanced care for our patients. We, also, welcomed two new faculty members: Dr. Chuck Scales, who recently finished a Robert Wood Johnson Foundation Clinical Scholars Fellowship in Health Sciences Research at UCLA and Dr. Sam Eaton, who recently completed an Endo-urology fellowship at Northwestern University. We had an extremely impressive showing at this year’s AUA meeting in San Diego. In fact, our Duke Urology alumni reception held on Saturday evening May 4, 2013 broke all attendance records. It was wonderful Glenn M. Preminger, MD Chief of the Division of Urology to see all of our DYSURICs and friends from across the country and around the world. We anticipate an equally impressive showing at the upcoming AUA meeting in Orlando in 2014. This past June, we graduated three outstanding chief residents, John Mancini, Suzanne Stewart and Brian Whitley. I had the opportunity to see all three at Brian’s wedding in Durham. John, Suzanne and Brian all appear to be enjoying their current positions. We are extremely proud of these individuals and know that they will stay in contact with the program. We are especially proud of our residents who have achieved major accomplishments over the past few months. Tara Ortiz received a Urology Care Foundation 2013 Residency Research Award at the AUA meeting in San Diego and Zarine Balsara represented Duke Urology on the Southeastern Section team that won the Annual Residency Bowl during the AUA. There were also major accomplishments for our faculty. Brant Inman was named the Cary “We are especially Robertson Assistant Professor of Urology in June. In addition, John Wiener was named to the American Board of Urology Examination Comexcited about our mittee to write the questions for the Urology Board Exams, annual resi- upcoming 46th annual dent in-service exams, the SASP program, and Pediatric Urology Duke Urologic Certification Examination. Assembly Our newsletter includes updates on our progress here at Duke and symposium, which in our Duke Urology of Raleigh practice. In addition, Sherry Ross provides a wonderful update of our Pediatric Urology Research Program. Finally, will be held in John Wiener provides an update on Duke Urology CME activities. We are Pinehurst in early especially excited about our upcoming 46th annual Duke Urologic AsApril, 2014.” sembly symposium, which will be held in Pinehurst in early April, 2014. We would love to see as many DYSURIC’s as possible attending this meeting, as we will have a special dinner for our DYSURIA members. I believe that our alumni are our most loyal supporters. We value your ideas, feedback and contributions. With industry funding virtually at a standstill, it is becoming much more difficult to support the educational activities of our residency program. Never has it been more critical that we receive support from our alumni for the continued success of Duke Urology. I would urge you to consider making a contribution to the DYSURIA society, which will go 100% to help support urology resident training at Duke. As we strive to keep our program as one of the elite training programs in the country, your support of resident education becomes even more critical. Please consider making a year-end gift to DYSURIA. As always, we welcome you back to Durham for a visit so we can show you how much we have grown both within Duke Urology and at the Duke University Medical Center. All the best for a wonderful holiday season, Glenn FACULTY NEWS FEATURED FACULTY: Thomas Polascik, MD Dr. Polascik, who recently returned from the 6th International Symposium for Imaging and Focal Therapy in Prostate Cancer, has been actively engaged in this innovative treatment approach over the past 10 years. “Focal therapy fundamentally changes the approach to how prostate cancer is diag- Cary N Robertson, MD, Assistant Professorship Announcement Brant A. Inman, MD, MS, FRCSC Theodore N. Pappas, MD, Distinguished Professor of Surgical Innovation, Interim Chair, Department of Surgery is pleased to announce that Brant A. Inman, MD, MS, FRCSC 2 nosed and managed,” Thomas Polascik, Duke Urology. Focal therapy is an emerging technical approach that uses three dimensional imaging and targeted treatment to spare the prostate gland, and preserve the urinary and sexual function of the patient. Advances in both imaging and therapeutic technologies have enabled urologists to approach treatment in an entirely new way. New multi-parametric MRI technology can locate and target prostate cancer lesions more precisely than ever before, and new therapeutic devices such as cryotherapy, irreversible electroporation, and high intensity frequency ultrasound (HIFU) are in various stages of clinical trial and development. These new imaging technologies and therapeutic devices may significantly reduce the role of traditional surgical extirpation or radiation therapy. Dr. Polascik is involved in several research studies and clinical trials examining new technological releases. He is a firm believer that new technologies will improve patient outcomes, and safety, and lead not only to patient living longer after prostate cancer, but with a better quality of life. Dr. Polascik has been at Duke since 1998. He received his MD, at the University of Chicago in 1991, and completed his Urology Residency at Johns Hopkins in 1997. He has risen to the rank of Professor of Urology, and is currently the Director of Urologic Oncology and Director of the Genitourinary Focal Therapy Fellowship Program at Duke. He has published over 200 manuscripts on minimally invasive therapy, and oncologic urology, and is considered an international thought leader in focal therapy of prostate and renal cancers. Dr. Polascik is, also, an experienced practitioner of robotic surgery and is using this new minimally invasive approach to deliver highquality, more precise treatments to his patients. Using the da Vinci robotic system, Dr. Polascik provides nerve-sparing robotic prostatectomy to his patients, and has recently begun using a new imaging technology to perform partial nephrectomy for kidney cancer patients. The new imaging technology trademarked FireFly®, by Intuitive Surgical, Inc. is an imaging system that allows surgeons to locate cancerous lesions with more precision. The urologist injects an indocyanine fluorescent dye into the patient, which is then agitated with a laser, and glows fluorescent green. “The robotic system gives me a greater degree of articulation than traditional laparoscopy, and makes suturing much easier and more precise,” Thomas Polascik, Professor of Surgery Duke Urology. has been awarded the Cary N. Robertson, MD, Assistant Professorship Brant A. Inman, MD, MS, FRCSC, Assistant Professor, Division of Urology, has been awarded the Cary N. Robertson, MD, Assistant Professorship. This Duke Medicine endowed professorship honors our most distinguished physician-scientists who have demonstrated extraordinary academic excellence in advancing medical science and human health. Dr. Inman joined Duke in 2008 and is currently Vice Chief of Urology Research, Director of Clinical Trials for the Division of Urology, and a member of the Duke Institutional Review Board. His area of clinical expertise is the surgical treatment of genitourinary cancers, and in particular bladder, kidney, penile, and testicular cancer. From a research standpoint, Dr. Inman’s laboratory is focused on developing novel therapies and diagnostic tests for bladder cancer as well as exploring the immunologic aspects of genitourinary cancers. Nationally, Dr. Inman is a core member of the bladder and penile cancer panels of the National Comprehensive Cancer Network (NCCN). He is also on the Board of Directors of the Society of Urological Oncology Clinical Trials Committee and a member of the Bladder Cancer Advocacy Network (BCAN). He has consulted for Blue Cross Blue Shield of North Carolina and for the U.S. Environmental Protection Agency on issues pertaining to urologic health. Internationally, Dr. Inman currently serves as consulting editor for the Journal of European Urology. Dr. Inman received his undergraduate and medical degrees from the University of Alberta (Edmonton, Canada). He then completed his urology residency at Laval University (Québec, Canada) and his urologic oncology fellowship at the Mayo Clinic (Rochester, Minnesota). The Cary N Robertson Assistant Professorship was made possible by donations from Earnest and Mildred Mario, Stanley P. Porter, Ella Ann L. and Frank B. Holding Foundation, R.A Bryan Foundation, Sam and Nancy Chestnut and the Samuel L. Phillips Foundation. This fund commemorates the extraordinary contributions of current Duke Associate Professor, Dr. Cary N. Robertson, who continues to serve Duke as a teacher and scientist, advancing the field of urology. • DUKE UROLOGY UPDATE • FALL 2013 FACULTY AWARDS NEW FACULTY Charles Scales, Jr, MD Sam Eaton, MD Dr. Scales received his medical degree from Duke University in 2004 and stayed at Duke to complete both a urology residency in 2011 and a fellowship in endo-urology in 2012. He completed the Robert Wood Johnson Foundation Clinical Scholars Program at the University of California, Los Angeles in 2013. His clinical interests include medical and surgical management of kidney stone disease, shock wave lithotripsy, medical and minimally-invasive management of benign prostatic hyperplasia, and endoscopic management of urinary-tract obstruction. Dr. Scales returns to Duke as Assistant Professor of Urology and will be conducting his clinical practice at Duke University Hospital. Dr. Eaton received his medical degree from Columbia University College of Physicians and Surgeons in 2003. Following completion of his urology residency at Boston University in 2011, he completed a 2 year endo-urology fellowship at Northwestern University in Chicago that focused on both advanced stone management as well as laparoscopic and robotic surgery. His clinical interests include stone disease (including both medical and surgical management), prostate cancer (including robot-assisted prostatectomy), kidney cancer (focusing on minimally invasive and renal sparing techniques including robotic partial nephrectomy), upper tract urothelial cancer (including endoscopic management and robotic assisted nephroureterectomy), upper tract obstruction (endoscopic and laparoscopic/robotic management of UPJ obstruction and ureteral stricture disease), as well as general urology. Dr. Eaton joins the faculty as Assistant Professor of Urology and will practice at Duke Urology of Raleigh. George D. Webster, MB, FRCS was honored by the Society of Urodynamics, Female Pelvic Medicine and Urogenital Reconstruction for his leadership in fellowship training for the specialty of Female Pelvic Medicine and Reconstructive Surgery. Dr. Webster, along with Drs. Jerry Blaivis, Ed McGuire and Shlomo Raz were recognized as pioneers in the development of this specialty at a dinner and tribute entitled, “Standing on the Shoulders of Giants” in San Diego, CA, May 4, 2013. Edward N. Rampersaud Jr., MD was selected to serve on the NCCN Kidney Cancer Guidelines panel. Pei Zhong, Ph.D. was endowed as Anderson-Rupp Professor of Mechanical Engineering and Materials Science from July 1, 2013 to June 30, 2018. Glenn M. Preminger, MD received the prestigious St. Paul’s Medal from the British Association of Urological Surgeons for contributions to the field of Urology and was honored at the annual meeting in Manchester, England on June 20, 2013. DUKE UROLOGY UPDATE • FALL 2013 • 3 CLINICAL SECTION Community Urology: Using Webinars for Patient Education "The internet has changed how patients learn and cope with their disease. For physicians, the internet provides an opportunity to present wide-ranging and current information in a variety of teaching formats. The internet eliminates many of the traditional barriers to patient education and empowers patients with 24 hour access to high-quality, patient-centered resources," Aaron Lentz MD, Duke Urology of Raleigh. Delivering care to the patients of Wake County has given Duke Urologists a unique opportunity to our bring cutting edge therapies to a new patient population, and the staff at Duke Raleigh Hospital provide outstanding care and service to our patients” Cary N. Robertson, Professor of Urology About Duke Urology of Raleigh In conjunction with Duke Raleigh Hospital, Dr. Lentz and the team of urologists at Duke Urology of Raleigh have begun providing patient education services by offering interactive webinars for patient education. The webinars are live presentations accessible to the public through the Duke Raleigh website, and allow for “real-time” question and answer sessions with our physicians. After a focused presentation, patients can submit questions via text message, instant message, or Twitter. The topics presented to date have focused on male-wellness including erectile dysfunction and low testosterone. In the future, the webinars will be expanded to cover many more urologic conditions. After conclusion of the live session, each webinar is uploaded to the Internet and can be accessed through YouTube (http://www.youtube.com/user/DukeRaleighNews) or the Duke Raleigh Hospital website. We are very proud of this outreach project and anticipate partnering with the hospital for additional patient service opportunities. 4 Duke Urology of Raleigh was established in 2010 on the Duke Raleigh Hospital Campus, and provides both inpatient and outpatient care to the Wake County community. The hospital has welcomed the services and expertise of Duke Urologists, and we provide a full service of oncological, reconstructive and general urological services using the latest advances in minimally invasive and robotic techniques. Location: 2480 Wake Forest Road, Raleigh, NC 27609 Urologic Cancer Survivorship Clinic The Urologic Cancer Survivorship Clinic is designed to meet the quality-of-life needs of the growing number of cancer survivors. Minimally invasive treatments, for example, can help patients with leakage of urine and • DUKE UROLOGY UPDATE • voiding dysfunction. Infertility can be addressed as well, with many new and effective therapies. The Survivorship Team is actively involved in research to assess new treatments – such as the male sling for incontinence (the procedure involves placement of a synthetic mesh in the groin to elevate the urethra and alter its position) – and outcomes studies that evaluate patient perceptions of survivorship before and after treatment in the clinic. Duke Urology is the first program in the country to offer specialized training in the treatment of conditions that affect cancer survivors’ quality of life. The Genitourinary Cancer Survivorship Fellowship at Duke University and the Durham Veterans Administration Medical Center is a one-year program that offers the fellow an opportunity to become proficient in the evaluation and management of all morbidities suffered by patients who have undergone treatment for urologic and pelvic malignancies. This program focuses on managing the genitourinary concerns and complications of patients who have undergone treatment for genitourinary, pelvic and other malignancies. The operative scope of the fellowship includes intra-abdominal and pelvic reconstruction, urinary stricture and fistula disease, erectile dysfunction, urinary incontinence and complex voiding dysfunction as a result of prior cancer treatment. Fellows also participate in multidisciplinary projects including urology, colorectal surgery, gynecology, radiation and medical oncology that attune them to the continuum of care for this group of patients. A structured training program in FALL 2013 cancer survivorship confers a unique set of medical and surgical skills to urologists who want to care for the burgeoning number of cancer survivors, while improving our patient care and research opportunities at the same time. “We are really a leader in this area,” says Drew Peterson (Clinic Medical Director), acknowledging an upcoming American College of Surgeons Commission on Cancer (CoC) requirement for all accredited programs to offer a survivorship program by 2015. Andrew C. Peterson, MD Men’s Health Day Duke Urologist’s participated in the Annual Duke Cancer Institute’s Men’s Health Day held in Durham on September 22 and 23, 2013. The event was held at Duke University Hospital and Lincoln Community Health Center. Duke Urologic Oncology faculty, Lincoln Community Health providers, Durham Diabetes Coalition and Healing with CAARE Inc. offered advice on prostate cancer risk assessment (based on the latest AUA recommendations), diabetes screening, blood pressure checks, and body mass index (BMI) screening. 19 faculty and staff for Urology attended the event and provided medical advice and screening services to the conference attendees. “In general, many men do not visit a doctor regularly”, says Judd Moul, MD, Duke Urologist and James H Semans Professor of Surgery, and this event brought many men in for a more comprehensive health assessment. Moul says the teams used the new American Urologic Association (AUA) Judd Moul, MD prostate early detection guidelines to inform men about their current and future risk for prostate cancer while doing this in the context of their overall health status. The Duke Urologic Oncology team performs its clinical work as a core part of the Duke Cancer Institute, in the newly opened Duke Cancer Center which has created a multi-disciplinary working environment were urologists, medical oncologists, and radiation oncologists collaborate to provide the best care and treatment for cancer patients. RESIDENT SECTION Resident Spotlight: Urology Care Foundation Award be developed which will substantially improve patient care in this population. “I am extremely proud that the research that we are conducting here at Duke has been recognized by the AUA, and that Tara K. Ortiz, MD received a the hard-work and dedication that prestigious Urology Care Foundation Tara has devoted to this project Residency Research Award at the has paid off. Dr. Seed and I are AUA annual meeting held in San looking forward to mentoring her Diego, CA, May 4-8, 2013. through her research year Dr. Ortiz, a third year Duke Urology experience, as she completes this Resident, is spending her research year project,” Sherry Ross, MD Pediatric Tara Ortiz, MD in basic science working under the Urology. mentorship of Sherry Ross, MD Tara’s research project titled: (Pediatric Urology) and Patrick Seed, MD PhD “The Role of Type I Pili in the Adherence and (Pediatrics). She is utilizing this teams novel urinary Invasion of Bladder Epithelium in a spinal Cord tract infection-spinal cord injury rat model to better injured rat model” was awarded the Russell Scott understand the increased susceptibility of the Jr. Urology Research Award. The Urology Care neurogenic bladder to urinary tract infections, a Foundation is the official foundation of the leading cause of morbidity and mortality in patients American Urological Association and offers these with a neurogenic bladder due to neurological awards to only four residents per year. Other award injury or abnormalities such as Spina Bifida. By recipients included residents from Columbia, better understanding the mechanisms that result Loyola and Stanford. in increased infections of the neurogenic bladder, “Tara’s recognition is a testament to the improved treatment and preventive therapies can quality of faculty mentorship and institutional DUKE UROLOGY UPDATE • FALL 2013 • 5 support that our residents receive during their research year experience here at Duke. We are proud to be supporting the development of the future generation of basic science researchers in Urology,” Steve Freedland, Urology Research Residency Director. About Urology Resident Research at Duke All residents in Urology at Duke spend a full year in dedicated academic research. This has been a long tradition at Duke and we are now one of only a few programs in the country to offer such an experience. We firmly believe that this year is invaluable in training the future urological leaders of tomorrow. Whether our graduates will pursue academic careers or full-time clinical practice, they need to be experts in understanding the literature and how to interpret new scientific discoveries as they apply to their practice. What better way to understand the literature . Continued on next page RESIDENT Con’t. than to be a contributor? In addition, our residents gain a deep understanding of statistics – the language of how to communicate scientific findings. This year also provides valuable time for our residents to reflect on their careers and help formulate their career plans. Due in large part to this dedicated research year, Duke Urology has produced many leaders in urology from department chairs, to leading academicians, to premier clinicians. The dedicated research year is an important tradition for Duke Urology and one that we are extremely proud of. 2013 Incoming Residents (Class of 2019) Bryce A Allio, MD Medical School: New York – University of Rochester Eugene B. Cone, MD Medical School: Brown University Left to Right: Peterson, Balsara, Assimos, Preminger 2013 Graduating Residents Duke hosts North Carolina Urology Resident Symposium The Grandover Residency Retreat is an annual event where the three North Carolina urology programs (Duke, UNC and Wake Forest) meet for a research and debate competition. This is the 13th year of the event and was attended by 28 residents and 27 faculty. A nationally renowned visiting professor is brought in to give an educational lecture during the day’s events. This year, Dr. James Eastham, Chief of Urology at Memorial Sloan-Kettering gave our keynote lecture on "Clinically Localized Prostate Cancer". “This event gives residents the opportunity to network with their peers, and is an invaluable learning experience. We hope to continue being able to fund this and other educational opportunities for our residents in the future,” Michael Ferrandino, MD, Associate Program Director, Duke Urology Residency Program. Duke was represented well in the research and debate competition. Dr. Nicholas Kuntz took first place for his research presentation titled "Striking Dose and Time Dependency of Radiation Cystitis in the Rat: Repeat Cystometric Evaluation with Saline Alone and Potassium Chloride Challenge". Our residents, Rajeev Chaudry MD and Michael Granieri, MD, won their debates, with Duke bringing home 2 out of a possible 4 awards in the debate competition. 6 Resident Honors Zarine R. Balsara, MD, PhD was a member of the Southeastern Section team John G. Mancini, MD – Class of 2013 that won the American Urological AssociaPrivate Practice: United States Armed Forces tion Residency Bowl Competition at the AUA annual meeting held in San Diego, CA, May Suzanne B Stewart – Class of 2013 4-8, 2013. Uro-Oncology Fellowship – Mayo Clinic, MinTara K. Ortiz, MD received a Urology nesota Care Foundation 2013 Residency Research Award at the AUA annual meeting held in Brian M Whitley – Class of 2013 San Diego, CA, May 4-8, 2013. Private Practice: Sanford, North Carolina Tara K. Ortiz, MD was selected as a 2014 Feagin Leadership Scholar on July 29, 2013. This program gives scholars an opportunity to develop and apply their leadership skills to the Duke medical community and beyond. Michael A. Granieri, MD and Rajeev Chaudry, MD were winners for their urologic debates at the Annual North Carolina Urology Resident Symposium (“Grandover”) held in Greensboro, NC, September 7, 2013. Nicholas J. Kuntz, MD was first place winner for his research presentation at the Left to Right: Mancini, Stewart, Preminger, Annual North Carolina Urology Resident Symposium (“Grandover”) held in Greensboro, Whitley NC, September 7, 2013. “This past June, we graduated three outstanding chief residents, John Mancini, Suzanne Stewart and Brian Whitely. I just had the opportunity to see all three at Brian’s wedding in Durham last month. John (Military Urology practice in Colorado), Suzanne (SUO Fellowship, Mayo Clinic, Rochester, MN) and Brian (Group Practice, Sanford, NC) all appear to be enjoying their current positions. We are extremely proud of these individuals and know that they will continue to support Duke Urology,” Glen Preminger, Division Chief, Duke Urology. • DUKE UROLOGY UPDATE • FALL 2013 RESEARCH SECTION The Emergence of Health Services Research Q A Health Service Research is an emerging area; could you explain the importance of this type of investigation to the future of the field? Health services research, also known as population health science, focuses on four key aspects of health care: access to care, understanding care delivery, the financing of patient care, and patient outcomes. The Institute of Medicine has noted Interview with that important opportunities to improve the Chuck Scales quality and safety of patient care exist across all medical specialties. Health services research provides the scientific underpinning to identify opportunities to improve quality and safety, design systems to deliver effective, paWelcome back to Duke Campus, tient-centered care, and rigorously evaluate how does it feel to be back in North innovative methods of patient care. Carolina? Q A It is great to be back in North CarWhat specific areas of research are olina. My wife and I are very excited you planning to study? to return to Durham, which continues to grow and be a great place to raise a I am particularly interested in assessfamily. It is also a real privilege to join the facing the quality of urologic care delivulty at Duke, where I was a medical student ery and designing tools or and a resident. interventions to improve the quality of treatment for patients with both benign and malignant urologic conditions. Current projects You spent a year at UCLA as a focus on understanding care delivery for Robert Wood Johnson Foundation older adults with overactive bladder symp/VA Clinical Scholar, how as your ex- toms, and creating decision aids to help paperience? tients with kidney stones decide among various treatment and prevention options. The Clinical Scholars Program at Other efforts will focus on identifying opporUCLA was a phenomenal learning ex- tunities and methods for improving care deperience. Not only did I further de- livery for patients with oncologic velop my research skills, but I also provided malignancies. clinical care to underserved patients in Los Angeles County. Training in leadership and health policy were an integral part of the proWhy did you decide that Duke was gram. Finally, I had the opportunity to be part the place for you to begin this imporof the UCLA Health System team tasked with tant work? improving the quality of care by reducing inpatient mortality. The rich clinical history of Duke Urology and Duke Surgery, combined with the expertise and research infrastructure of the Duke Cancer Institute and the Duke Clinical Research Institute made a return to Durham very compelling. I’m excited to have the opportunity to begin my clinical practice and research career at Duke. Q A Q A Q A Pediatric Urology Research Research in the section of Duke Pediatric Urology continues to move forward and grow with exciting research in basic science, outcomes and clinical research. Dr. Tara Ortiz, a 3rd year Duke Urology resident is spending Sherry Ross, MD her research year in basic science working under the mentorship of Dr. Sherry Ross and Dr. Patrick Seed, who is instrumental in designing and overseeing collaborative laboratory projects. Dr. Ortiz is working to better understand the mechanisms that increase susceptibility to urinary tract infection in our novel neurogenicUTI rat model. We are eager to learn more about these interactions since a better understanding of urinary tract infections in the neurogenic bladder will encourage the development of preventive therapies for recurrent UTIs in this population. Dr. Erin McNamara, a former Duke Urology chief resident who is currently a fellow of pediatric urology at Boston Children’s Hospital, presented the results of our project titled “Evaluation of Cold Ischemia for Preservation of Testicular Function during Partial Orchiectomy in the Rat Model” at the Society of Pediatric Urology national meeting in Las Vegas in September. This study was inspired by the increased use of partial orchiectomy in children with benign appearing testicular tumors and a recent study suggesting that cold ischemia during testicular torsion may be beneficial. We hypothesized that cold ischemia during partial orchiectomy in the pre-pubertal rat would improve serum testosterone, sperm count and histology in the post-pubertal period. Interestingly, we found that there was no significant difference in testosterone levels or sperm count between cold and warm ischemia but that histological parameters were significantly worse in the cold ischemia group. This study suggests that cold ischemia is not beneficial during partial orchiectomy. The Continued on next page DUKE UROLOGY UPDATE • FALL 2013 • 7 . RESEARCH Con’t. manuscript for this study will be submitted for consideration for publication in the Journal of Urology. Dr. Jonathan Routh is continuing his efforts to better understand urologic diseases in children through outcomes research efforts. Dr. David Chu, a current Duke Urology chief resident and Dr. Routh were invited to present their work as a podium presentation at the Society of Pediatric Urology national conference. This interesting study found that in a large, nationwide pediatric cohort, radical nephrectomy remained the most common primary surgical intervention for pediatric renal tumors. However, over the study period nephron sparing surgery was consistently performed in 11% of pediatric renal tumor cases. Importantly, they noted a significant regional variation in the use of nephron sparing surgery and association with a concomitant diagnosis of renal failure/insufficiency, but not with any other clinical or socioeconomic factors. In addition, Dr. Routh and Dr. Scott Wang, a 3rd year Urology resident, are working very hard this year on multiple projects including a project titled “Patterns in Emergency Care among Spina Bifida Patients: a Case-Control Study” where they will investigate the national patterns of emergency care among spina bifida patients compared to non-spina bifida controls. In addition, they are utilizing the Surveillance, Epidemiology, and End Results (SEER) database to examine nephron sparing surgery (NSS) outcomes and factors associated with NSS use in Wilms Tumor. Last, we are very excited to announce that Dr. Routh was recently awarded a K-12 grant for his work titled “Comparative Effectiveness of Vesicoureteral Treatments in Children”. We are very proud of Dr. Routh and look forward to his continued research efforts that enhance our knowledge and improve the care of children in pediatric urology. 8 RECENT SIGNIFICANT PAPERS Beebe-Dimmer JL, Freedland SJ. Androgen Deprivation Therapy: Further Confirmation of Known Harms. BJU Int 111(5): 690-691, May 2013. Thomas JA, Antonelli JA, Bañez LL, Hoyo C, Grant D, Demark-Wahnefried W, Platz EA, Gerber L, Shuler K, Eyoh E, Calloway E, SJ. Androgenetic Alopecia at VarFreedland Caso J, Masko EM, li JA, Poulton SH, Deious Ages and Prostate Cancer Risk in an whirst M, Pizzo SV, Freedland SJ. The Effect Equal-Access Multiethnic Case-Control Series of Carbohydrate Restriction on Prostate Canof Veterans. Cancer Causes Control 24(5): cer Tumor Growth in a Castrate Mouse 1045-1052, May 2013. Xenograft Model. Prostate 73(5): 449-454, April 2013. Allott EH, Masko EM, Freedland SJ. Obesity Routh JC, Grundy PE, Anderson JR, Retik AB, and Prostate Cancer: Weighing the Evidence. Kurek KC. B7-h1 as a Biomarker for Therapy Eur Urol 63(5): 800-809, May 2013. Failure in Patients with Favorable Histology Wilms Tumor. J Urol 189(4): 1487-1492, Masko EM, Allott EH, Freedland SJ. The Relationship Between Nutrition and Prostate April 2013. Cancer: Is More Always Better? Eur Urol Singh AA, Jones LW, Antonelli JA, Gerber L, 63(5): 810-820, May 2013. Calloway EE, Shuler KH, Freedland SJ, Grant DJ, Hoyo C, Bañez LL. Association Be- Fizazi KS, Higano CS, Nelson JB, Gleave M, tween Exercise and Primary Incidence of Miller K, Morris T, Nathan FE, McIntosh S, Prostate Cancer: Does Race Matter? Cancer Pemberton K, Moul JW. Phase III, Randomized, Placebo-Controlled Study of Docetaxel 119(7): 1338-1343, April 2013. in Combination with Zibotentan in Patients with Metastatic Castration-Resistant Prostate Tsivian M, Caso JR, Kimura M, Polascik TJ. Cancer. J Clin Oncol. 31(14): 1740-1747, Renal Tumors in Solid Organ Recipients: ClinMay 2013. ical and Pathologic Features. Urol Oncol 31(3): 255-258, April 2013. Clark PE, Spiess PE, Agarwal N, Biagioli MC, Abern MR, Owusu RA, Anderson MR, Ram- Eisenberger MA, Greenberg RE, Herr HW, persaud EN, Inman BA. Perioperative Intrav- Inman BA, Kuban DA, Kuzel TM, Lele SM, esical Chemotherapy in Non-Muscle-Invasive Michalski J, Pagliaro L, Pal SK, Patterson A, Bladder Cancer: A Systemic Review and Plimack ER, Pohar KS, Porter MP, Richie JP, Meta-Analysis. J Natl Compr Canc Netw. Sexton WJ, Shipley WU, Small EJ, Trump DL, Wile G, Wilson TG, Dwyer M, Ho M. Penile 11(4): 477-484, April 2013. Cancer: Clinical Practice Guidelines in OncolGupta RT, Kauffman CR, Polascik TJ, Taneja ogy. J Natl Compr Canc Netw. 11(5): 594SS, Rosenkrantz AB. The State of Prostate 615, May 2013. MRI in 2013. Oncology 27(4): 262-270, April Inman BA, Etienne W, Rubin R, Owusu RA, 2013. Oliveira TR, Rodriques DB, Maccarini PF, Stauffer PR, Mashal A, Dewhirst MW. The ImWalter LC, Fung KZ, Kirby KA, Shi Y, Espalpact of Temperature and Urinary Condon R, O’Brien S, Freedland SJ, Powell AA, stituents on Urine Viscosity and its Relevance Hoffman RM. Five-Year Downstream Outto Bladder Hyperthermia Treatment. Int J Hycomes Following Prostate-Specific Antigen perthermia 29(3): 206-210, May 2013. Screening in Older Men. JAMA Intern Med. 173(10): 866-873, May 2013. Klink JC, Tewari AK, Masko EM, Antonelli J, Inman BA, Harrison MR, George DJ. Novel Febbo PG, Cohen P, Dewhirst MW, Pizzo SV, Immunotherapeutic Strategies in Develop- Freedland SJ. Resveratrol Worsens Survival ment for Renal Cell Carcinoma. Eur Urol in SCID Mice with Prostate Cancer Xenografts in a Cell-Line Specific Manner, 63(5): 881-889, May 2013. Through Paradoxical Effects on Oncogenic Pathways. Prostate 73(7): 754-762, May 2013. • DUKE UROLOGY UPDATE • FALL 2013 Moreira DM, Bañez LL, Presti JC Jr, Aronson WJ, Terris MK, Kane CJ, Terris MK, Amling CL, Freedland SJ. High Serum Folate is Associated with Reduced Biochemical Recurrence after Radical Prostatectomy: Results from the SEARCH Database. Int Braz J Urol 39(3): 312-319, May-June 2013. Goldsmith ZG, Oredein-McCoy O, Gerber L, Bañez LL, Sopko DR, Miller MJ, Preminger GM, Lipkin ME. Emergent ureteric stent vs percutaneous nephrostomy for obstructive urolithiasis with sepsis: Patterns of use and outcomes from a 15-year experience. BJU Int 112(2): E122-128, July 2013. Solomon KR, Allott EH, Freeman MR, Freedland SJ. Re: Dysregulation of Cholesterol Homeostasis in Human Prostate Cancer Through Loss of ABCA1. Eur Urol 63(6): 1128-1129, June 2013. Freedland SJ. Dietary fat and reduced prostate cancer mortality: Does the type of Cookson MS, Roth BJ, Dahm P, Engstrom C, fat matter? JAMA Intern Med 173(14): 1326- Freedland SJ, Hussain M, Lin DW, Lowrance 1327, July 2013. WT, Murad MH, Oh WK, Penson DF, Kibel AS. Castration-resistant prostate cancer: Inman BA.Words of wisdom: Re: Final re- AUA guideline. J Urol 190(2): 429-438, Ausults of an EORTC-GU cancers group ran- gust 2013. domized study of maintenance bacillus Calmette-Guerin in intermediate- and high- Carter HB, Albertsen PC, Barry MJ, Etzioni R, risk Ta, T1 papillary carcinoma of the urinary Freedland SJ, Greene KL, Holmberg L, bladder: One-third dose versus full dose and Kantoff P, Konety BR, Murad MH, Penson DF, 1 year versus 3 years of maintenance. Eur Zietman AL. Early detection of prostate canUrol 64(1): 171-172, July 2012. cer: AUA guideline. J Urol 190(2): 419-426, August 2013. Tsivian M, Abern MR, Qi P, Polascik TJ. Short-term functional outcomes and compli- van den Bergh RC, Albertsen PC, Bangma cations associated with transperineal tem- CH, Freedland SJ, Graefen M, Vickers A, plate prostate mapping biopsy. Urology van der Poel HG. Timing of curative treat82(1): 166-170, July 2013. ment for prostate cancer: A systematic review. Eur Urol 64(2): 204-215, August 2013. Madden-Fuentes RJ, McNamara ER, Lloyd JC, Wiener JS, Routh JC, Seed PC, Ross SS. Lotan Y, Amiel G, Boorjian SA, Clark PE, Variation in definitions of urinary tract infec- Droller M, Gingrich JR, Guzzo TJ, Inman BA, tions in spina bifida patients: A systematic re- Kamat AM, Karsh L, Nielsen ME, Smith ND, view. Pediatrics 132(1): 132-139, July 2013. Shariat SF, Svatek RS, Taylor JM; Bladder Cancer Think Tank, and Bladder Cancer AdvoGbadegesin RA, Brophy PD, Adeyemo A, cacy Network. Comprehensive handbook for Hall G, Gupta IR, Hains D, Bartkowiak B, Ra- developing a bladder cancer cystectomy binovich CE, Chandrasekharappa S, Hom- database. Urol Oncol 31(6): 812-826, Austad A, Westreich K, Wu G, Liu Y, Holanda gust 2013. D, Clarke J, Lavin P, Selim A, Miller S, Wiener JS, Ross SS, Foreman J, Rotimi C, Winn MP. Balsara ZR, Ross SS, Dolber PC, Wiener TNXB mutations can cause vesicoureteral re- JS, Tang Y, Seed PC. Enhanced susceptibilflux. J Am Soc Nephrol 24(8): 1313-1322, ity to urinary tract infection in the spinal cordJuly 2013. injured host with neurogenic bladder. Infect Immun 81(8): 3018-3026, August 2013. Tsivian M, Polascik TJ. Bilateral focal ablation of prostate tissue using low-energy di- Kokorowski PJ, Routh JC, Hubert K, Graham rect current (LEDC): A preclinical canine DA, Nelson CP. Trends in revision circumcistudy. BJU Int 112(4): 526-530, August 2013. sion at pediatric hospitals. Clin Pediatr 52(8): 699-706, August 2013. Preminger GM. Micro-percutaneous nephrolithotomy (micro-PNL) vs retrograde intra-renal surgery (RIRS): dealer’s choice? The devil is in the details. BJU Int 112(3): 280281, August 2013. Muller RL, Gerber L, Moreira DM, Andriole G Jr, Hamilton RJ, Fleshner N, Parsons JK, Freedland SJ. Obesity is Associated with Increased Prostate Growth and Attenuated Prostate Volume Reduction by Dutasteride. Eur Urol 63(6): 1115-1121, June 2013. Moul JW. Prostate Cancer: Active Surveillance in African American Men. Nat Rev Urol. 10(6): 311-312, June 2013. Wang AJ, Goldsmith ZG, Wang C, Nguyen G, Astroza GM, Neisius A, Iqbal MW, Neville AM, Lowry C, Toncheva G, Yoshizumi TT, Preminger GM, Ferrandino MN, Lipkin ME. Obesity Triples the Radiation Dose of Stone Protocol Computerized Tomography. J Urol 189(6): 2142-2146, June 2013. Wu C, Aronson WJ, Terris MK, Presti JC Jr., Amling CL, Freedland SJ. Diabetes Predicts Metastasis after Radical Prostatectomy in Obese Men: Results from the SEARCH Database. BJU Int. 111(8): E310-318, June 2013. Inman BA, Abern MR. Interpreting a study on bladder cancer screening. Eur Urol 64(1): 48-50, July 2013. Magnon C, Hall SJ, Lin J, Xue X, Gerber L, Freedland SJ, Frenette PS. Autonomic nerve development contributes to prostate cancer progression. Science 341(6142): 1236361, July 2013. Teeter AE, Presti JC Jr, Aronson WJ, Terris MK, Kane CJ, Amling CL, Freedland SJ. Do nomograms designed to predict biochemical recurrence (BCR) do a better job of predicting more clinically relevant prostate cancer outcomes than BCR? Urology 82(1): 53-58, July 2013. DUKE UROLOGY UPDATE • FALL 2013 • Freedland SJ, Gerber L, Reid J, Welbourn W, Tikishvili E, Park J, Younus A, Gutin A, Sangale Z, Lanchbury JS, Salama JK, Stone S. Prognostic utility of cell cycle progression score in men with prostate cancer after primary external beam radiation therapy. Int J Radiat Oncol Biol Phys 86(5): 848-853, August 2013. 9 ALUMNI SECTION He joined the Urology staff at Duke University Medical Center in 1965, became Assistant Professor in 1966, Associate Professor in 1969 and Professor in 1972. He has had active reserve duty entering as Captain in 1961 The Duke Youthful Society of Urology and exiting as Lieutenant Colonel in 1971. Residents Interested in Advancement (DYAfter his retirement in 2002, Dr. AnderSURIA) was established in 1966 and is the of- son assumed the role of resident mentor at ficial alumni association of Duke Urology. the Durham VA Hospital where he continues DYSURIA currently has over 295 active to teach and advise residents two days a alumni and honorary members and is a key week. To those of us at Duke, Everett is best contributor to the success of the Duke Urol- known for his teaching and patient care skills, ogy Residency Program as well as his wonderful sense of humor. “The pressures of modern healthcare economics on educational funding, has made it challenging for academic programs to continue to find the financial resources to enrich the resident educational experience,” Drew Peterson, Program Director, Duke Urology Residency Program. The E. Everett Anderson Education Fund will be funded by an annual gift giving campaign that we are asking our alumni to support. Reinvigoration of the DYSURIA Community The Duke Urology Residency Program has been training residents since 1966 and has graduated more than 100 leaders in the field. The proud legacy of the Duke program is the success of its graduates and their contributions to the lives of patients with urologIt is with the greatest of gratitude that ical diseases across the country. The current we are proud to announce the E. Everett reputation and success of the Duke Urology Anderson Education Fund, a new fundraising Residency Program is the result of the efforts initiative to honor the educational legacy of all graduates of the program, who have cultivated by Dr. Anderson in his more than helped shape the program and through their 48 years of dedicated service to Duke individual achievements continue to generUniversity. This new fund will be used to ate a source of pride for the Program. support the educational needs of the The modern pressures of clinical pracUrology Residency Program. tice, education and research make it chal“Everett has been an integral fixture in lenging for us all to come together as a Duke Urology for over 40 years and he con- community, and as a result we are announctinues to educate our medical students, resi- ing a new structure for the DYSURIA group, dents and fellows. Everett has forgotten that will now be led by an alumni committee more in Urology than I will ever know,” Glenn Preminger MD, Division Chief, Duke Urology. Edward Everett Anderson was born in Durham, North Carolina on May 10, 1932. He was educated at Phillips Academy, entered Duke and received his BS in 1954 and MD in 1958. He trained at Duke, Yale, the Washington School of Medicine in Seattle and the Peter Bent Brigham Hospital, Boston. Everett Anderson Education Fund 10 • DUKE UROLOGY UPDATE • DYSURIA Committee Co-Chairs A new committee is being formed to help manage and shape the future of DYSURIA. Drs. John Wiener and Jeff Taber will be working to establish the committee to improve networking and communication; develop scientific and social programs, and raise funds to support current Duke residents. In 2014, DYSURIA will increase its networking opportunities and invites alumni to attend the following events: DYSURIA Calendar 2014 April 5, 2014 DYSURIA Dinner at the Duke Urology Assembly Pinehurst, North Carolina May 16, 2014 [tentative] DYSURIA Cocktail Party at the AUA Orlando, Florida FALL 2013 June 20, 2014 DYSURIA 5th and 25th Year Graduates at the Annual Chief Residents’ Graduation Dinner Durham, North Carolina CONTINUING MEDICAL Duke EDUCATION SECTION Tuesday Lecture Series November Duke Urologic Assembly 2014 Symposium Dean G. Assimos, MD, Chairman of Urology at the University of Alabama-Birmingham was the Duke Tuesday guest faculty speaker on November 12. Dr. Assimos delivered the keynote lecture on “Urinary Oxalate: How Did It Get There and How to Reduce It.” Duke faculty speaking that day included Stephen J. Freedland, MD (Lifestyle and Prostate Diseases), Michael R. Harrison, MD (GU Oncologist – Treatments for Metastatic Renal Carcinoma), and Michael E. Lipkin, MD (Imaging for Urolithiasis). 2014 Duke Tuesday Education Series Morris Center for Research Lectureship The 2013 Duke Tuesday in Urology, Morris Center for Research Lectureship was held on July 23, 2013. The guest lecturer was Thomas W. Jarrett, MD, Chairman of Urology at George Washington University, who spoke on “What is meant by Limited Life Expectancy and How It Relates to Urologic Malignancies.” Dr. Jarrett attended Duke University as an undergraduate with current Duke Urology faculty member, Dr. John Wiener and was the Urology Residency Program Director at George Washington University when current Duke Faculty Member, Sherry Ross was a trainee there. The event was attended by over 100 members of the urologic community across the state. Duke Urology continues to provide invaluable educational forums to local, regional and national practicing urologists. The Duke Tuesday Educational Series is held three times per year, and provides local and regional urologists with the opportunity to learn from national leaders across the country. The Morris Lectureship was made possible by the kind donation from the Morris Family Foundation. February 11, 2014 Christopher Saigal, MD, MPH Professor and Vice Chair of Urology, UCLA July 15, 2014 Morris Center for Research Lectureship Joel B Nelson, MD Professor and Chair of Urology University of Pittsburgh School of Medicine November 4, 2014 John E. Dees Lectureship John W Brock III, MD Professor and Chief, Division of Pediatric Urology, Monroe Carell Jr. Children’s Hospital, Vanderbilt University • FALL 2013 History of the DUA The Duke Urologic Assembly was established to meet the scientific and educational needs of Duke Alumni and practicing urologists. The first meeting was held in 1966 in the Jack Tar Hotel in Durham and was named the Symposium Urologic Education. Donations To register for the Duke Tuesday Education Series for 2014 register at the Duke CME Website or contact Robin Phillips, CMECoordinator, robin.phillips@duke. edu. This lecture series offers 3.0 PMA Continuing Education Credits per lecture. DUKE UROLOGY UPDATE The 46th Annual Duke Urologic Assembly (DUA) will return to its roots and be held April 3 – April 6, 2014 in the historic village of Pinehurst for the first time since 1992. This year’s format includes a dedicated day focused on oncology. Thursday, April 3rd will be the Duke Urologic Cancer Symposium jointly hosted by Duke Urology and the Duke Cancer Institute, with 13 Duke urologic oncologists, medical oncologists, and radiation oncologists speaking on the latest diagnostic, medical, and surgical aspects of urologic cancer management. Friday, April 4th – Sunday, April 6th will be focus on urologic diseases and treatments. Attendees have the opportunity to enjoy the spa facilities, family recreational activities, and any one of Pinehurst’s eight world-class golf courses. As a special event, a limited number of golf tee times on the world famous Pinehurst No. 2 Golf Course have been reserved for Friday afternoon. This course will also host the US Open and US Women’s Open Championships just two months later. If you wish to play No. 2 that day, please contact Robin Phillips at 919-6683532. Registration information will be available on the Urology website at http://urology.surgery.duke.edu/cme. To reserve your hotel room and tees for additional rounds of golf, please call the Pinehurst Resort directly at 1-877-403-2874. A block of rooms is being held at a special rate but you will need to book early as these are in high demand. • Charitable gifts are a driving force in the current success and future achievements of our physicians, educators, and scientists. If you are interested in learning more about supporting Duke Urology, please contact Jillian Ream, Duke Medicine Development and Alumni Affairs, jillian.ream@duke.edu or 919-385-3197. 11 LEADING EDGE UROLOGY 46th DUKE UROLOGIC ASSEMBL BL LY Y and DUKE UROLOGIC CANCER SYMPOSIUM Thursday y, April 3 – Sunday nday y, April 6, y, 6 2014 PINEHURST CONFERENCE CENTER in the historic village of PINEHURST RST T,, NORTH CAROLINA Presented by Duke Urology Duke Cancer Institute A Division of the Department of Surgery Sponsored by Duke University School of Medicine 12 • DUKE UROLOGY UPDATE • FALL 2013 Agenda Thursday, April 3, 2014 Session I ONCOLOGY: Localized Prostate Cancer 8:30 am Welcome/Opening Remarks 8:35 am Active Surveillance and Surgery – Moul 8:55 am Contemporary Radiation Therapy – Lee 9:15 am Hormones and Other Systemic Therapies in Non-Metastatic Prostate Cancer – George 9:35 am Racial Disparities in Prostate Cancer – Patierno 9:55 am Case Discussion 10:20 am Break Session II ONCOLOGY: Advanced Renal Cell Carcinoma 10:30 am Differences in Outcome Between Academic and Community Medical Centers – Hirsch 10:50 am Treatment Selection for Newly Metastatic Kidney Cancer – George 11:10 am What To Do When First Line Therapy Fails – Harrison 11:30 am Case Discussion 12:00 pm Lunch in Carolina Dining Room 5:00 pm 5:30 pm Cutting Edge: Molecular Characterization of Prostate Cancer – Harrison Panel Discussion Adjourn Friday, April 4, 2014 Session VI ONCOLOGY: Renal Cell Carcinoma 8:00 am Cytoreductive Nephrectomy and Metastasectomy – Rampersaud 8:20 am Surveillance of Renal Masses – Uzzo 8:40 am Management of Alternative Histologies in RCC – George 9:00 am Panel Discussion 9:20 am Break Session VII UROLOGY: Focal Therapy 9:30 am Modern Imaging of Renal and Prostate Tumors-Impact on Focal Ablative Therapies – Gupta 9:50 am Prostate Focal Therapy: Cryotherapy and Nanoknife – Polascik 10:10 am Prostate HIFU – Robertson 10:30 am Renal Focal Therapy: Cryotherapy and Radiofrequency Ablation – Polascik 10:50 am Panel Discussion 11:10 am Break Session III ONCOLOGY: Bladder Cancer 1:00 pm Surgery for Locally Advanced Bladder Cancer – Inman 1:20 pm Neo-adjuvant and Adjuvant Therapy: Who Should Get It and Why – Milowsky 1:40 pm Chemoradiation for Bladder Cancer – Lee 2:00 pm Panel Discussion 2:20 pm Break Session IV ONCOLOGY: Immunotherapy in Urologic Cancers 2:30 pm Cancer and the Immune System: The Basics – Nair 2:50 pm Immunotherapy and Surgery – Inman 3:10 pm Immunotherapy in Renal Cell Carcinoma: Is There Still a Role for This – Inman 3:30 pm Case Discussion 3:50 pm Break Session V ONCOLOGY: Advanced Prostate Cancer 4:00 pm Natural History and Hormonal Therapy for Metastatic Prostate Cancer – Freedland 4:20 pm What To Do When Hormonotherapy Fails – George 4:40 pm Session VIII UROLOGY: Other GU Malignancies 11:20 am Embracing a Neoadjuvant Approach for Upper Tract Urothelial Tumors – Walther 11:40 am Early Stage Testis Cancer: How to Decide Which Avenue to Use – Robertson 12:00 pm Panel Discussion 12:20 pm Adjourn Saturday, April 5, 2014 Session IX UROLOGY: Stones 8:00 am Adjuvant Medical Therapy Following Surgical Stone Management – Preminger 8:20 am AUA Guidelines for Imaging Known or Suspected Ureteral Calculi – Lipkin 8:40 am Ureteral Stone Management SWL v URS - Are we doing the right thing – Scales 9:00 am Panel Discussion 9:20 am Break 10:10 am 10:30 am 10:50 am 11:10 am Session XI UROLOGY: Renal Masses 11:20 am Radiologic Work Up of Renal Masses – Leder 11:40 am VICTOR A. POLITANO LECTURESHIP presented by Robert Uzzo, MD – Nephrometry Scores 12:20 pm Adjourn Sunday, April 6, 2014 Session XII UROLOGY: Pelvic Floor & Male Reconstruction 8:00 am Management of Vesicovaginal and Ureterovesical Fistulae – Le 8:20 am Rectourethral Fistula; Algorithmic, Team-based Approach to a Complex Problem – Peterson 8:40 am Pharmacotherapy for Benign Urinary Tract Dysfunctions-State of the Art 2014 – Fraser 9:00 am Panel Discussion 9:20 am Break Session XIII UROLOGY: Andrology 9:30 am AUA Vasectomy Guidelines – Viviano 9:50 am Non-Surgical Management of Peyronie’s Disease: Options and Efficacy – Lentz 10:10 am Advances in Medical Therapy for BPH – Scales 10:30 am Testosterone Replacement Therapy and Prostate Cancer: An Update – Viviano 10:50 am Panel Discussion 11:10 am Break Session XIV UROLOGY: Pediatrics 11:20 am Contemporary Management of Vesicoureteral Reflux – Routh 11:40 am Urinary Tract Infection in the Neurogenic Bladder: What We’ve Learned – Ross 12:00 pm Managing Pediatric Voiding Dysfunction – Wiener 12:20 pm Panel Discussion 12:40 pm Closing Remarks 12:50 pm Adjourn Session X UROLOGY: Endourology/Robotics 9:30 am UPJ Obstruction – Ferrandino 9:50 am Robotics – Eaton DUKE UROLOGY UPDATE • FALL 2013 Endoscopic Management of Ureteral Strictures – Lipkin Open Management of Ureteral Strictures – Peterson Panel Discussion Break • 13 Faculty 2014 CONFERENCE MEDICAL DIRECTORS John S. Wiener, MD Associate Professor of Surgery Associate Professor in Pediatrics Section Head, Pediatric Urology Department of Surgery, Division of Urology Duke University Medical Center Michael R. Harrison, MD Assistant Professor of Medicine Department of Medicine, Division of Oncology Member of the Duke Cancer Institute Bradford R. Hirsch, MD Assistant Professor of Medicine Department of Medicine, Division of Oncology Member in the Duke Clinical Research Institute Daniel J. George, MD Associate Professor of Medicine Associate Professor in Urology Director, GU Oncology, Duke Cancer Institute Department of Medicine, Medical Oncology Duke University Medical Center Brant A. Inman, MD, MS, FRCSC Cary N. Robertson, MD, Assistant Professor Department of Surgery, Division of Urology Member of the Duke Cancer Institute Cary N. Robertson, MD Associate Professor of Surgery Practice Director, Duke Urology of Raleigh Director, GU Surgical Oncology, Duke Raleigh Cancer Center Member of the Duke Cancer Institute Richard A. Leder, MD Associate Professor of Radiology Clinical Associate in Surgery Department of Radiology, Division of Abdominal Imaging Sherry S. Ross, MD Assistant Professor of Surgery Assistant Professor in Pediatrics Director of Pediatric Urology Research Director of Pediatric Urology Stone Clinic Department of Surgery, Division of Urology W. Robert Lee, MD, MEd, MS Professor of Radiation Oncology Associate Professor of Surgery Department of Radiation Oncology Member of the Duke Cancer Institute GUEST FACULTY Richard C. Rink, MD, FAAP, FACS Robert A. Garrett Professor, Pediatric Urology Riley Hospital for Children Indiana University School of Medicine Indianapolis, Indiana Jonathan C. Routh, MD, MPH Assistant Professor of Surgery Assistant Professor in Pediatrics Department of Surgery, Division of Urology Aaron C. Lentz, MD Assistant Professor of Surgery Department of Surgery, Division of Urology Matthew I. Milowsky, MD Associate Professor of Medicine Section Chief, Genitourinary Oncology Service UNC Lineberger Comprehensive Cancer Center Chapel Hill, North Carolina Michael E. Lipkin, MD Assistant Professor of Surgery Department of Surgery, Division of Urology DUKE UNIVERSITY FACULTY Samuel H. Eaton, MD Assistant Professor Department of Surgery, Division of Urology Michael N. Ferrandino, MD Assistant Professor of Surgery Director, Minimally Invasive Urologic Surgery Associate Residency Program Director Department of Surgery, Division of Urology Glenn M. Preminger, MD James F. Glenn, MD, Professor of Urology Chief, Division of Urologic Surgery Department of Surgery, Division of Urology Edward N. Rampersaud Jr., MD Assistant Professor of Surgery Department of Surgery, Division of Urology Ngoc-Bich (Nikki) Le, MD Assistant Professor of Surgery Department of Surgery, Division of Urology 2014 Victor A. Politano, MD, Lectureship GUEST FACULTY SPEAKER Robert Uzzo, MD, FACS G. Willing “Wing” Pepper Chair in Cancer Research Professor and Chairman, Department of Surgery Fox Chase Cancer Center Temple University School of Medicine Fox Chase Cancer Center Philadelphia, PA Thomas J. Polascik, MD Professor of Surgery Director, Society of Urologic Oncology Program Director, Genitourinary Program on Focal Therapy Department of Surgery, Division of Urology Member of the Duke Cancer Institute Charles D. Scales Jr., MD, MSHS Assistant Professor of Surgery Department of Surgery, Division of Urology Member in the Duke Clinical Research Institute Judd W. Moul, MD, FACS James H. Semans, MD, Professor of Surgery Professor of Anesthesiology Department of Surgery, Division of Urology Member of the Duke Cancer Institute Charles J. Viviano, MD, PhD Assistant Professor of Surgery Department of Surgery, Division of Urology Smita Kesavan Nair, PhD Associate Professor of Surgery Department of Surgery, Division of Surgical Sciences Member of the Duke Cancer Institute Philip J. Walther, MD, PhD, FACS Professor of Surgery Associate Professor of Pathology Department of Surgery, Division of Urology Chief of Urology, VA Medical Center, Durham Member Duke Cancer Institute Steven R. Patierno, PhD Deputy Director, Duke Cancer Institute Professor of Medicine Department of Medicine, Division of Oncology Matthew O. Fraser PhD Associate Professor of Surgery Department of Surgery, Division of Urology David F. Paulson, MD Professor Emeritus of Surgery Department of Surgery, Division of Urology Stephen J. Freedland, MD Associate Professor of Surgery Associate Professor in Pathology Department of Surgery, Division of Urology Member of the Duke Cancer Institute Andrew C. Peterson, MD Associate Professor of Surgery Department of Surgery, Division of Urology Rajan T. Gupta, MD Assistant Professor of Radiology Director, Abdominal Imaging Fellowship Program Department of Radiology, Division of Abdominal Imaging 14 • DUKE UROLOGY UPDATE • FALL 2013 LEADING EDGE UROLOGY 46th DUKE UROLOGIC ASSEMBLY and DUKE UROLOGIC CANCER SYMPOSIUM Thursdayy, April 3 – Sund Sunday dayy,, April 6, 2014 GOLF ACTIVITY Featuring 8 unique golf courses, making it the largest golf resort in America, Pinehurst will be on the world’s stage as the site of the 2014 U.S. Open and Women's Open Championships two short months after the DUA conference. Duke has secured a very limited number of golf tee times on the world famous Pinehurst ayy,, April 4, 2014. Due to extremely limited availability, golf is on a first come, first serve Course No. 2 for Friday basis. The Friday activity slots are being held for only a limited number of golfing participants until Friday, November 8, 2013. TTo o reserve your sleeping room and tee time, please call the Pinehurst resort directly at 1-877-403-2874. You You may also reserve additional rounds of golf you wish to play at the same time. TRA AVEL Pinehurst is situated at 80 Carolina Vista Drive in the Village of Pinehurst, North Carolina. Raleigh-Durham International is the most accessible airport to the resort. Pinehurst offers special rates from RDU via their in-house transportation department. Call (910) 235-8465 for reservations, which should be made at least 48 hours in advance. Once you're at Pinehurst, their in-house transportation team offers complimentary shuttle service within the resort property. With a US or Canadian driver’s license, you may also enjoy use of an Acura RL, TL, MDX, RDX or the new ZDX for up to 3 hours off-property as part of their complimentary Acura Guest Drive Program. y Accommodations HOTEL ACCOMMODA MMODA ATIONS TIONS Duke has reserved a block of rooms. TTo o reserve your room, please call the Pinehurst resort directly at 1-877-403-2874. At Pinehurst, you can meet all morning and still enjoy the beauty of an afternoon in the glorious Carolina sunshine, whether it's on the course, the courts, or the bikes in the charming Village. Registration $150.00 $575.00 $675.00 $400.00 Physician Registration to Duke Urologic Cancer Symposium (one day conference) includes Syllabus, Thursday Luncheon, and Reception PA, NP P,, RN Registration to Urologic Cancer Symposium (one day conference) includes Syllabus, Thursday Luncheon, and Reception REGISTER BEFORE February 27, 2014 for EARLLY Y BIRD REGIS REGISTRA STRA ATION TION for entire Leading Edge Urology gy y four day conference Physician Early Registration to both Urologic Cancer Symposium and Duke Urologic Assembly (four ( r day conference) includes Syllabus, Thursday Luncheon, Reception, three breakfasts, breaks, and Saturday Luncheon Physician Registration after February 27, 2014 Physician Registration to Urologic Cancer Symposium and Duke Urologic Assembly (fou ( ur day conference) PA, NP P,, RN Registration to Urologic Cancer Symposium and Duke U l i A Urologic Assembly bly (four day conference) includes Syllabus, Thursday Luncheon, Reception, three breakfasts, breaks, and Saturday Luncheon REGISTRA ATION WEBSITE https://continuingeducation.dcri.duke.edu/2014-Leading-Edge-Urology CANCELLA ATION TIO POLICY All refund requests will be subject to a $100.00 processing fee. No refunds will be issued after March 2, 2014. Contact Information Robin Phillips, Program Coordinatort robin.phillips@duke.edu or 919-668-3532 DUKE UROLOGY UPDATE • FALL 2013 • 15 on $300.00 n CONFERENCE REGISTRA ATION TION First Class Mail U.S. Postage Duke Urology PAI D Division of the Department of Surgery Permit No. 60 Durham, NC Duke South, White Zone, Rm 1571-A Mail: DUMC 3707, Durham, NC 27710 DUKE UROLOGIC ASSEMBLY • 2014 SYMPOSIUM COURSE DESCRIPTION With over eight decades of experience in caring for patients with urologic diseases, Duke’s Division of Urologic Surgery has established itself as a world leader in urologic care, research, and education. The Duke Urologic Assembly began in the 1970’s and was held annually at Pinehurst; we are excited to return to our roots at Pinehurst for the first time in decades. LEADING EDGE UROLOGY: 46th Annual Duke Urologic Assembly will evaluate the most recent advances in the diagnostic evaluations, therapeutic options, management of complications, and technologies that provide leading edge care to patients. Participants will be engaged through moderated discussions and interactive lectures on the latest evidence-based approaches to managing a wide range of urologic conditions across the spectrum of life. In partnership with our colleagues in the Duke Cancer Institute we will designate Thursday of the DUA for the DUKE UROLOGIC CANCER SYMPOSIUM; a full day CME event featuring lectures by Duke and guest Medical Oncologists, Radiation Oncologists, and Urologists speaking on the latest diagnostic, medical, and surgical aspects of urologic cancer management. There will be separate as well as combined registration for the Cancer Symposium with the DUA. STATEMENT OF NEED Improvements in the treatment of urologic conditions generate a great need for knowledge and up-to-date information for providers and health care professionals. An outstanding roster of speakers in a comprehensive, scientific program encompassing the sub-specialties of urology, as well as medical and radiation oncologists treating urologic malignancies has been assembled. This conference is an integral part of continuing education for health care professionals nationwide. TARGET AUDIENCE Addressing current issues and technologies in the practice of Urology, this conference will enhance knowledge in treating urologic conditions and help improve patient care by Urologists; Medical Oncologists; Radiation Oncologists; Internal, Family and Geriatric Medical Practitioners; Physician Assistants; Radiation Technicians; Nurse Practitioners; Nurses; Residents; and other Allied Health Medical Staff. LEARNING OBJECTIVES • Evaluate and outline management options for the patient with various urologic conditions • Review the latest advances in the treatment of advanced prostate cancer • Identify latest updates in management of bladder cancer, upper tract urothelial cancer, renal cell carcinoma, and adrenal disorders • Extend improved patient counseling and generate patient satisfaction regarding therapy choice • Examine concepts of the medical management of nephrolithiasis, as well as surgical therapy of both renal and ureteral calculi ACCREDITATION The Duke University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. CREDIT DESIGNATION The Duke University School of Medicine designates this live activity for a maximum of 20 AMA PRA Category 1 Credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity.