BIOL 2020/BCHM 2020 - Biochemistry
Winter 2013 Course Outline
Lecturer: Dr. Keith Wheaton, room 243 Farquharson Building
416-736-2100 x20893
Lectures: Tues & Thurs 10:00 am to 11:30 am LAS: C
Office hours: Tues & Thurs 1:00-2:00
e-mail policy:
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Please post questions about the course material on moodle not to my
personal e-mail. I will create a forum for each section.
Do not contact me if you miss an exam. Note also that I will not contact
students who have missed an exam. It is your responsibility to obtain
documentation and hand it to the undergrad biology office with in a week,
otherwise you will receive zero.
Do not e-mail me to ask about the format of exams or what is going to be
covered on the exams. I will cover this sufficiently in class or address
these questions on moodle.
I will not reply to e-mail that ignores any of the above points.
Required text: Fundamentals of Biochemistry, Voet,Voet & Pratt 4th Ed. 2013.
Course website: Located at moodle.yorku.ca and will include PDF files of slides
and recordings of lectures
Grading & Test dates:
Mid-term-1
Feb 7th 2013
 30%
0nline assignment Mar 1st
 5%
Mid-term-2
Mar 14th 2013
 25%
Final exam
TBA
 40%.
Test/Exam format:
Exams will be predominantly multiple-choice, approx. 24 questions on each
midterm and 36 questions on the final exam. There will be some fill in the blank
questions and drawing of relevant structures of amino acids and nucleotides
Course Outline
Class
Topics
1
2
3
4
5
6
7
8
9
STRUCTURE & FUNCTION
Jan 8: Introduction to biochemistry
Properties of Water
Jan 10: pH, pKA and buffers
Amino Acids
Jan 15:Peptides, proteins 1o , 2o and 3o structure
Jan 17: 4o structure
Jan 22:Enzymes & thermodynamics
Jan 24:Enzyme, kinetics & inhibition
Jan 29: lipids & membranes
Jan 31: Signal Transduction
Experimental Biochemistry
Feb 5: Review of Structure and function
Chapters
1&2
3&4
5&6
7
1 &11
12
9 &10
10 & 13
3
MIDTERM-1 FEB 7, 2012 30% in class
METABOLIC PATHWAYS
10 Feb12: Carbohydrates & Bioenergetics
11 Feb14: Glycolysis
WINTER BREAK FEB 16-22
12 Feb 26: Regulation of Glycogen
13 Feb 28: Citric acid cycle
8 &14
15
16
17
ONLINE Assignment due Mar 1st 5%
14 Mar 5: Electron transport
15 Mar 7: Integration of metabolism
16 Mar 12: Review Metabolic pathways
18
22
MIDTERM-2: Mar 14th, 2012 25% In class
17
18
19
20
21
22
MOLECULAR BIOLOGY
Mar 19: DNA, RNA, structure/function
Mar 21: DNA Replication
Mar 26: Transcription & RNA Processing
Mar 28: Genetic code & protein Synthesis
Apr 2: Gene Expression
Apr 4: Review of Molecular biology
FINAL: TBA 40%
3 & 24
25
26
27
28
Chapters correspond to Fundamentals of Biochemistry: Voet and Voet 4th Ed.. Coverage
of chapters will not be complete, and where indicated the lectures will cover only
selected topics from the chapter. Students are advised to attend all lectures and study
those sections of the text relevant to the lecture topics. Exam questions will relate to the
lecture topics and any related information presented in the lectures that may not be
covered in the textbook.
This second year course will focus on a wide range of topics within Biochemistry.
In order to fully understand the material presented during lecture, a basic
understanding of chemical principles and cellular molecular biology (SC/BIOL
1000 3.00 and SC/BIOL 1001 3.00 or SC/BIOL 1010 6.00; both SC/CHEM 1000 3.00
and SC/CHEM 1001 3.00, or SC/CHEM 1000 6.00) will be expected of candidate
students.
This course emphasizes the ability to apply knowledge gained in BIOL2020.
As a consequence, testing will include questions that test the ability of the
student to synthesize data and anticipate outcomes from principles learned.
Midterms: If a mid-term is missed with a valid excuse and documentation (e.g.
illness with a doctor’s note), the weight will be transferred to the final exam. You
must provide valid documentation (the note must state that you were
unable to be present for the test/exam) within 7 days of the midterm exam.
Do not contact me, submit the documentation directly to the undergrad
office (Farquharson Building 108). NOTE: I will pick these notes up after a
week, but will not assess them until the end of the year when I am tallying final
marks. No Note = No Mark for the exam and no transfer of its weight to the
final. Also note that I will not transfer the weight of 2 missed midterms to
the final, you will receive a mark of zero for one.
Deferred final exam: If you miss the final exam with a valid excuse and
documentation, you must fill out a Deferred Standing Agreement Form (see the
Biology Undergraduate Office) as soon as possible after the exam and have it
signed by the course director (Keith Wheaton). Make-up final exams will be given
during the Biology deferred exam period in the spring of 2013. The format of the
make-up final exam for this course may be essay and/or multiple-choice. The
final must be taken or the student cannot pass BIOL2020.