Worksheets_ASM_Kreuzer_557067
7/26/07
8:59 AM
Page 39
Worksheet 25.2 for Human Molecular Genetics
Write the genotype of the individuals in the blanks
provided. If an individual could have more than one
genotype, write all that apply.
Bob
Susan
Genotype
Child
Genotype
1. What protein does the “PKU gene” encode?
2. How can two normal parents have a child affected with PKU?
3. If Bob and Susan have another child, will it also have PKU?
4. Explain how the “PKU gene” causes PKU and why Bob and Susan don’t have the disease but their child
does. Use your knowledge of cellular biochemistry.
5. Is PKU a dominant or recessive genetic disease? What is the molecular explanation of your answer?