1
CURRICULUM VITAE
Jan-Åke Gustafsson
Born in 1943, August 4.
Bachelor of Medicine, Karolinska Institute, Stockholm, 1964.
Ph.D. at the Department of Chemistry, Karolinska Institute, 1968.
M.D. 1971.
Associate Professor in Chemistry, Karolinska Institute, 1971.
Professor of Chemistry, Karolinska Institute, 1976.
Professor of Chemistry, University of Gothenburg, 1978.
Professor of Medical Nutrition and Chairman of the Department of Medical Nutrition, Huddinge
University Hospital, Karolinska Institute, Stockholm, 1979.
Director of the Center for Biotechnology, Huddinge University Hospital, Karolinska Institute, 1985.
Founder of KaroBio AB 1987 (a campus-situated biotechnology company sponsored by pension
and governmental funds with about 130 employees).
Awards and related activities
The Svedberg Prize in Chemistry, Stockholm, 1982.
The Fernström Prize of the Karolinska Institute, 1983.
Member of the Nobel Assembly of the Karolinska Institute, 1986.
Honorary Member of the Japanese Biochemical Society, 1986.
Adjunct Full Professor at the Department of Cell Biology, Baylor College of Medicine, Houston,
Texas, since 1987.
Honorary Member of the American Society for Biochemistry and Molecular Biology, 1990.
Consultant to The Rockefeller University Hospital since 1991.
The Anders Jahre Prize, Oslo, 1992.
Medal from Collège de France, Paris, 1992.
Keith Harris Lecture, Australian Endocrine Society, Adelaide, 1992.
Gregory Pincus Medal and Award, Worcester Foundation, 1994.
Sterling Visiting Professor, University of Pennsylvania, Philadephia, 1995.
Member of the Swedish Academy of Sciences, 1997.
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Member of the Swedish Academy of Engineering Sciences, 1998.
The Söderberg Prize in Medicine, 1998.
Adjunct Member of the Nobel Committee of the Karolinska Institute, 1998Fogarty Scholar NIH, 1999.
Medal of the IngaBritt and Arne Lundberg’s Research Foundation, 1999.
Curt Nicolin’s Prize for Achievements for the Development of South Stockholm, 2000.
European Medal, British Society for Endocrinology, 2000.
Foreign Honorary Member of the American Academy of Arts and Sciences, 2000.
Burroughs Wellcome Fund Lecture, Boston, 2000.
Center for Bioenvironmental Research Distinguished Visiting Professor, Tulane University, New
Orleans, 2000.
Garvan International Fellow, November 2000.
One of ISI Top 258 Researchers in Biology & Biochemistry, 2000.
Vice chairman of the Nobel Assembly of the Karolinska Institute, 2001.
Lorenzini Gold Medal, Lorenzini Foundation, 2001.
The AF Group Prize for the creation of Novum Research Park, 2001
Fred Conrad Koch Award (Endocrine Society USA), 2002.
Chairman of the Nobel Assembly of the Karolinska Institute, 2002.
Foreign Honorary Member of the US National Academy of Sciences, 2002.
Commandeur dans l’Ordre des Palmes Académiques, 2002.
Burroughs Wellcome Fund Visiting Professor in the Basic Medical Sciences at the University of
Texas Medical Branch School of Medicine, 2002.
McDowell Lecture in Physiology, King´s College, London, U.K., 2003
Marius Tausk Visiting Professor at the Leiden University Medical Centre (LUMC), 2003.
J.G. Moore Visiting Professor, UCLA, USA, 2003.
FEBS Lectureship Datta Award, 2003.
Bristol-Meyers Squibb/Mead Johnson Award for Nutrition Research, 2004.
Medal from Biomedicum Helsinki, 2004.
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Other activities
Invited lecturer at more than 400 international symposia since 1970.
Member, currently and/or previously, of the editorial board or similar position in Steroids, The
Journal of Steroid Biochemistry and Molecular Biology, Molecular Endocrinology, Breast Cancer
Research and Treatment, The Prostate, Anticancer Research, Japanese Journal of Cancer Research,
Journal of Molecular Medicine, Molecular Pharmacology and the International Journal of
Oncology.
Recipient of three NIH grants for studies on the dioxin receptor, hormonal control of liver
carcinogenesis and chemical carcinogenesis of the prostate, respectively.
Has been member of the Faculty Board of the Karolinska Institute and regularly carries out various
assignments for the President’s Office of the Karolinska Institute.
Has participated in several international reviewing panels, e.g. as chairman of a board evaluating the
Norwegian Biotechnology Program (October/November 1991); member of a board evaluating the
Biocenter Oulu (May 1993); member of a board evaluating the Center for Biotechnology, Helsinki,
(February 1994); chairman of a board evaluating the Center for Biotechnology, University of Oslo
(February 1995).
Has had and has several appointments at and tasks for The Swedish Board for Planning and
Coordination of Research, The Swedish Medical Research Council, The Swedish Cancer Society,
The Swedish Environmental Protection Agency and The Swedish Fund for Strategic Research.
Regular co-organizer of The Summer School of Signal Transduction held in Spetsai, Greece, every
two years since 1990.
Has participated in organizing the following symposia:
1983
Nobel symposium “Steroid hormone receptors: Structure and function”.
1988
2nd CBT Symposium “The steroid/thyroid hormone receptor family and gene regulation”.
1993
5th CBT Symposium “Intracellular hormone receptors and ligan-dependent
transcriptional regulation”.
1995
7th CBT Symposium “Nuclear orphan receptors: Novel regulators in physiology and
pathology”.
1995
EMBO Workshop; Structure and Function of Steroid and Nuclear Receptors, Alghero,
Sardinia, Italy.
1997
9th CBT Symposium “Steroid and orphan nuclear receptors”.
1999
Nobel symposium “Estrogens and women’s health – benefit or threat?”
1999
EMBO Workshop; Steroid and Nuclear receptors, Villefranche, France.
2000
10th CBT symposium “Nuclear receptors in health and disease”.
2001
EMBO Workshop on Nuclear Receptor Structure and Function, Erice, Italy.
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2002
“Nuclear Receptors 2002”, A joint International Symposium arranged by the Center for
Biotechnology (CBT), Karolinska Institutet in collaboration with the Summer University
of Southern Stockholm.
2003
EMBO Conference, Biology of Nuclear Receptors, Villefranche-sur-Mer, France.
2003
Nobel Conference No 40: “Transcriptional control of lipid homeostasis”.
2003
FEBS Advanced Study Institute, International Summer School on “From Transcription to
Physiology: Regulation of Gene Expression and Protein Function in an Integrated
Context”, Island of Spetses, Greece.
2004
“Nuclear Receptors 2004” An International Symposium arranged by the Center for
Biotechnology (CBT), Karolinska Institutet.
Member of the International Advisory Board of the WHO Center in Oulu since 1995.
Has participated in the supervision of 84 Ph.D. students to the presentation of their thesis.
Has supervised 110 postdocs/visiting scientists.
Has more than 1100 peer-reviewed publications. Can be sent upon request.
SELECTED PUBLICATIONS
This is a list of selected publications. The complete list contains around 1100 publications and can
be sent upon request.
1.
J.-Å. Gustafsson and J. Sjövall: Steroids in germfree and conventional rats. VI.
Identification of 15- and 21-hydroxylated C21 steroids in faeces from germfree rats. Eur.
J. Biochem. 6, 236-247, 1968.
2.
J.-Å. Gustafsson, R. Ryhage, J. Sjövall and R.M. Moriarty: Migrations of the
trimethylsilyl group upon electron impact in steroids. J. Am. Chem. Soc. 91, 1234-1236,
1969.
3.
P. Eneroth and J.-Å. Gustafsson: Steroids in newborns and infants. Hydroxylated
cholesterol derivatives in the steroid monosulphate fraction from meconium. FEBS Lett.
3, 129-132, 1969.
4.
P. Eneroth and J.-Å. Gustafsson: Steroids in newborns and infants. Identification of
20,22-dihydroxycholesterol from the monosulphate and "disulphate" fractions in human
meconium. FEBS Lett. 5, 99-103, 1969.
5.
I. Björkhem and J.-Å. Gustafsson: Mechanism of microbial transformation of cholesterol
into coprostanol. Eur. J. Biochem. 21 428-432, 1971.
6.
J.-Å. Gustafsson and A.S. Goldman: Steroid monosulphates in urine from male rat
pseudohermaphrodites. Endocrinology 90, 931-935, 1972.
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7.
C. von Bahr, K. Brandt and J.-Å. Gustafsson: On the participation of cytohrome P-450 in
the formation of 16,17-dihydroxylated C19 steroids from 16-dehydro-C19 steroids. FEBS
Lett. 25, 64-68, 1972.
8.
J.-Å. Gustafsson and M. Ingelman-Sundberg: Sex-specific 15-hydroxylation of
sulphoconjugated 15-androstane-3,17 -diol in liver microsomes from female rats.
FEBS Lett. 31, 292-296, 1973.
9.
K. Einarsson, J.-Å. Gustafsson and B.E. Gustafsson: Differences between germfree and
conventional rats in liver microsomal metabolism of steroids. J. Biol. Chem. 248, 36233630, 1973.
10.
K. Einarsson, J.-Å. Gustafsson and Å. Stenberg: Neonatal imprinting of liver microsomal
hydroxylation and reduction of steroids. J. Biol. Chem. 248, 4987-4997, 1973.
11.
A. Berg and J.-Å. Gustafsson: Regulation of hydroxylation of 5-androstane-3,17-diol
in liver microsomes from male and female rats. J. Biol. Chem. 248, 6559-6567, 1973.
12.
J.-Å. Gustafsson and Å. Stenberg: Irreversible androgenic programming at birth of
microsomal and soluble liver enzymes active on 4-androstene-3,17-dione and 5androstane-3,17-diol. J. Biol. Chem. 249, 711-718, 1974.
13.
J.-Å. Gustafsson and Å. Stenberg: Neonatal programming of androgen responsiveness of
liver of adult rats. J. Biol. Chem. 249, 719-723, 1974.
14.
R.-J. Begue, J.-Å. Gustafsson and A.S. Goldman: New potent inhibitors of 3-hydroxy∆5-steroid oxidoreductase with short duration of action. Endocrinology 95, 238-246,
1974.
15.
J.-Å. Gustafsson and M. Ingelman-Sundberg: Regulation and properties of a sex-specific
hydroxylase system in female rat liver microsomes active on steroid sulphates. I. General
characteristics. J. Biol. Chem. 249, 1940-1945, 1974.
16.
J.-Å. Gustafsson and Å. Pousette: Properties of nuclear 5-reductase in rat liver.
Biochemistry 13, 875-881, 1974.
17.
J.-Å. Gustafsson and Å. Stenberg: Masculinization of rat liver enzyme activities
following hypophysectomy. Endocrinology 95, 891-896, 1974.
18.
J. Carlstedt-Duke, J.-Å. Gustafsson and S.A. Gustafsson: Sexual differences in hepatic
metabolism and intracellular distribution of corticosterone studies by pulse-labeling with
[1,2,6,7-3H]corticosterone. Biochemistry 14, 639-648, 1975.
19.
J.-Å. Gustafsson and M. Ingelman-Sundberg: Regulation and substrate specificity of a
steroid sulfate-specific hydroxylase system in female rat liver microsomes. J. Biol.
Chem. 250, 3451-3458, 1975.
20.
M. Ingelman-Sundberg, A. Rane and J.-Å. Gustafsson: Properties of hydroxylase systems
in the human fetal liver active on free and sulphoconjugated steroids. Biochemistry 14,
429-437, 1975.
21.
J.-Å. Gustafsson, Å. Pousette, Å. Stenberg and Ö. Wrange: High-affinity binding of 4androstene-3,17-dione in rat liver. Biochemistry 14, 3942-3948, 1975.
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22.
B.H. Shapiro, A.S. Goldman and J.-Å. Gustafsson: Masculine-like hypothalamicpituitary axis in the androgen-insensitive genetically male rat pseudohermaphrodite.
Endocrinology 97, 487-492, 1975.
23.
J.-Å. Gustafsson and Å. Pousette: Demonstration and partial characterization of cytosol
receptors for testosterone. Biochemistry 14, 3094-3101, 1975.
24.
J.-Å. Gustafsson, A. Larsson, P. Skett and Å. Stenberg: Influence of a novel hypophyseal
factor on steroid metabolism in cultured hepatoma cells. Proc. Natl. Acad. Sci. USA 72,
4986-4990, 1975.
25.
B.E. Gustafsson, K. Einarsson and J.-Å. Gustafsson: Influence of cholesterol feeding on
liver microsomal metabolism of steroids and bile acids in conventional and germ-free
rats. J. Biol. Chem. 250, 8496-8502, 1975.
26.
J.-Å. Gustafsson and Å. Stenberg: Partial masculinization of rat liver enzyme activities
following treatment with FSH. Endocrinology 96, 501-504, 1975.
27.
A. Berg, J.-Å. Gustafsson, M. Ingelman-Sundberg and K. Carlström: Characterization of
a cytochrome P-450-dependent steroid hydroxylase system present in Bacillus
megaterium. J. Biol. Chem. 251, 2831-2838, 1976.
28.
J.-Å. Gustafsson and Å. Stenberg: On the obligatory role of the hypophysis in sexual
differentiation of hepatic metabolism in rats. Proc. Natl. Acad. Sci. USA 73, 1462-1465,
1976.
29.
P. Eneroth, J.-Å. Gustafsson, A. Larsson, P. Skett and Å. Stenberg: Feminization of
hepatic steroid metabolism in male rats with a transplanted pituitary tumor (MtT/F4). Cell
7, 413-417, 1976.
30.
J.-Å. Gustafsson, M. Ingelman-Sundberg, Å. Stenberg and T. Hökfelt: Feminization of
hepatic steroid metabolism in male rats following electrothermic lesion of the
hypothalamus. Endocrinology 98, 922-926, 1976.
31.
J.-Å. Gustafsson and Å. Stenberg: Specificity of neonatal, androgen-induced imprinting
of hepatic steroid metabolism in rats. Science 191, 203-204, 1976.
32.
J.-Å. Gustafsson, Å. Pousette and E. Svensson: Sex-specific occurrence of androgen
receptors in rat brain. J. Biol. Chem. 251, 4047-4054, 1976.
33.
K. Einarsson, J.-Å. Gustafsson, T. Ihre and M. Ingelman-Sundberg: Specific metabolic
pathways of steroid sulphates in human liver microsomes. J. Clin. Endocrinol. Metab. 43,
56-63, 1976.
34.
J.-Å. Gustafsson and J. Bergman: Iodine- and chlorine-containing oxidation agents as
hydroxylating catalysts in cytochrome P-450-dependent fatty acid hydroxylation
reactions in rat liver microsomes. FEBS Lett. 70, 276-280, 1976.
35.
P. Skett, P. Eneroth, J.-Å. Gustafsson and C. Sonnenschein: Changes in hepatic steroid
metabolism in rats following transplantation of four different clones of pituitary tumor
cells. Endocrinology 100, 1090-1096, 1977.
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36.
M. Ingelman-Sundberg and J.-Å. Gustafsson: Resolution of multiple forms of
phenobarbital-induced liver microsomal cytochrome P-450 by electrofocusing on
granulated gels. FEBS Lett. 74, 103-106, 1977.
37.
K. Fuxe, T. Hökfelt, P. Eneroth, J.-Å. Gustafsson and P. Skett: Prolactin-like
immunoreactivity: localization in nerve terminals of rat hypothalamus. Science 196, 899900, 1977.
38.
M. Snochowski, Å. Pousette, P. Ekman, D. Bression, L. Andersson, B. Högberg and J.Å. Gustafsson: Characterization and measurement of the androgen receptor in human
benign prostatic hyperplasia and prostatic carcinoma. J. Clin. Endocrinol. Metab. 45,
920-930, 1977.
39.
A. Löfström, P. Eneroth, J.-Å. Gustafsson and P. Skett: Effects of estradiol benzoate on
catecholamine levels and turnover in discrete areas of the median eminence and the
limbic forebrain, and on serum luteinizing hormone, follicle stimulating hormone and
prolactin concentrations in the ovariectomized female rat. Endocrinology 101, 15591569, 1977.
40.
B.E. Gustafsson, B. Angelin, K. Einarsson and J.-Å. Gustafsson: Effects of cholesterol
feeding on synthesis and metabolism of cholesterol and bile acids in germfree rats. J.
Lipid Res. 18, 717-721, 1977.
41.
Ö. Wrange and J.-Å. Gustafsson: Separation of the hormone- and DNA-binding sites of
the hepatic glucocorticoid receptor by means of proteolysis. J. Biol. Chem. 253, 856-865,
1978.
42.
Ö. Wrange, B. Nordenskjöld and J.-Å. Gustafsson: Cytosol estradiol receptor in human
mammary carcinoma: An assay based on isoelectric focusing in polyacrylamide gel.
Anal. Biochem. 85, 461-475, 1978.
43.
K. Fuxe, B.B. Fredholm, S.-O. Ögren, L.F. Agnati, T. Hökfelt and J.-Å. Gustafsson:
Ergot drugs and central monoamine mechanisms: a histochemical, biochemical and
behavioral analysis. Fed. Proc. 37, 2181-2191, 1978.
44.
J.-Å. Gustafsson, P. Eneroth, T. Hökfelt and P. Skett: Central control of hepatic steroid
metabolism: effect of discrete hypothalamic lesions. Endocrinology 103, 141-151, 1978.
45.
M. Ingelman-Sundberg, J. Montelius, J. Rydström and J.-Å. Gustafsson: The active form
of cytochrome P-45011ß from adrenal cortex mitochondria. J. Biol. Chem. 253, 50425047, 1978.
46.
B.E. Gustafsson, B. Angelin, K. Einarsson and J.-Å. Gustafsson: Influence of
cholestyramine on synthesis of cholesterol and bile acids in germfree rats. J. Lipid Res.
19, 972-977, 1978.
47.
Ö. Wrange, J. Carlstedt-Duke and J.-Å. Gustafsson: Purification of the glucocorticoid
receptor from rat liver cytosol. J. Biol. Chem. 254, 9284-9290, 1979.
48.
J.-Å. Gustafsson, L. Rondahl and J. Bergman: Iodosylbenzene derivatives as oxygen
donors in cytochrome-P-450 catalyzed steroid hydroxylations. Biochemistry 18, 865-870,
1979.
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49.
A. Berg, M. Ingelman-Sundberg and J.-Å. Gustafsson: Purification and characterization
of cytochrome P-450meg. J. Biol. Chem. 254, 5264-5271, 1979.
50.
J. Carlstedt-Duke, Ö. Wrange, E. Dahlberg, J.-Å. Gustafsson and B. Högberg:
Transformation of the glucocorticoid receptor in rat liver cytosol by lysosomal enzymes.
J. Biol. Chem. 254, 1537-1539, 1979.
51.
Ö. Wrange, J. Carlstedt-Duke and J.-Å. Gustafsson: Purification of the glucocorticoid
receptor from rat liver cytosol. J. Biol. Chem. 254, 9284-9290, 1979.
52.
P. Ekman, M. Snochowski, E. Dahlberg, D. Bression, B. Högerg and J.-Å. Gustafsson:
Steroid receptor content in cytosol from normal and hyperplastic human prostates. J.
Clin. Endocrinol. Metab. 49, 205-215, 1979.
53.
B. Forsgren, P. Björk, K. Carlström, J.-Å. Gustafsson, Å. Pousette and B. Högberg:
Purification and distribution of a major protein in rat prostate that binds estramustine, a
nitrogen mustard derivative of estradiol-17. Proc. Natl. Acad. Sci. USA 76, 3149-3153,
1979.
54.
K. Fuxe, K. Andersson, T. Hökfelt, V. Mutt, L. Ferland, L.F. Agnati, D. Ganten, S. Said,
P. Eneroth and J.-Å. Gustafsson: Localization and possible function of peptidergic
neurons and their interactions with central catecholamine neurons, and the central actions
of gut hormones. Fed. Proc. 38, 233-234, 1979.
55.
Ö. Wrange, G. Norstedt and J.-Å. Gustafsson: The estrogen receptor in rat liver:
quantitative and qualitative analysis by isoelectric focusing in polyacrylamide gel.
Endocrinology 106, 1455-1462, 1980.
56.
J.-Å. Gustafsson, Å. Pousette and Ö. Wrange: Predictive tests in treatment of breast and
prostatic carcinoma based on steroid receptor assays. Trends in Pharmacological
Sciences, pp. 279-281, June, 1980.
57.
E. Dahlberg, M. Snochowski and J.-Å. Gustafsson: Removal of hydrophobic compounds
from biological fluids by a simple method. Anal. Biochem. 106, 380-388, 1980.
58.
J.E. Bakke, J.-Å. Gustafsson and B.E. Gustafsson: Metabolism of propachlor by the
germfree rat. Science 210, 433-435, 1980.
59.
S. Okret, J. Carlstedt-Duke, Ö. Wrange, K. Carlström and J.-Å. Gustafsson:
Characterization of an antiserum against the glucocorticoid receptor. Biochim. Biophys.
Acta 667, 205-219, 1981.
60.
E. Dahlberg, M. Snochowski and J.-Å. Gustafsson: Regulation of the androgen and
glucocorticoid receptors in rat and mouse skeletal muscle cytosol. Endocrinology 108,
1431-1440, 1981.
61.
G. Norstedt, Ö. Wrange and J.-Å. Gustafsson: Multihormonal regulation of the estrogen
receptor in rat liver. Endocrinology 108, 1190-1196, 1981.
62.
G. Norstedt, A. Mode, P. Eneroth and J.-Å. Gustafsson: Induction of prolactin receptors
in rat liver after the administration of growth hormone. Endocrinology 108, 1855-1861,
1981.
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63.
A. Mode, G. Norstedt, B. Simic, P. Eneroth and J.-Å. Gustafsson: Continuous infusion of
growth hormone feminizes hepatic steroid metabolism in the rat. Endocrinology 108,
2103-2108, 1981.
64.
F. Payvar, Ö. Wrange, J. Carlstedt-Duke, S. Okret, J.-Å. Gustafsson and K.R.
Yamamoto: Purified glucocorticoid receptors bind selectively in vitro to a cloned DNA
fragment whose transcription is regulated by glucocorticoids in vivo. Proc. Natl. Acad.
Sci. USA 78, 6628-6632, 1981.
65.
J. Carlstedt-Duke, S. Okret, Ö. Wrange and J.-Å. Gustafsson: Immunochemical analysis
of the glucocorticoid receptor: identification of a third domain separate from the steroidbinding and DNA-binding domains. Proc. Natl. Acad. Sci. USA 79, 4260-4264, 1982.
66.
A. Mode, J.-Å. Gustafsson, J.-O. Jansson, S. Edén and O. Isaksson: Association between
plasma level of growth hormone and sex differentiation of hepatic steroid metabolism in
the rat. Endocrinology 111, 1692-1697, 1982.
67.
R. Toftgård, J. Halpert and J.-Å. Gustafsson: Xylene induces a cytochrome P-450
isozyme in rat liver similar to the major isozyme induced by phenobarbital. Molecular
Pharmacol. 23, 265-271, 1983.
68.
G. Norstedt, A. Mode, T. Hökfelt, P. Eneroth, R. Elde, L. Ferland, F. Labrie and J.-Å.
Gustafsson: Possible role of somatostatin in the regulation of the sexually differentiated
steroid metabolism and prolactin receptor in rat liver. Endocrinology 112, 1076-1090,
1983.
69.
J.-Å. Gustafsson, A. Mode and G. Norstedt: Central control of prolactin and estrogen
receptors in rat liver - expression of a novel endocrine system, the hypothalamo-pituitaryliver axis. Ann. Rev. Pharmacol. Toxicol. 23, 259-278, 1983.
70.
J.-Å. Gustafsson, A. Mode, G. Norstedt and P. Skett: Sex steroid induced changes in
hepatic enzymes. Ann. Rev. Physiol. 45, 51-60, 1983.
71.
A. Mode, G. Norstedt, P. Eneroth and J.-Å. Gustafsson: Purification of liver feminizing
factor from rat pituitaries and demonstration of its identity with growth hormone.
Endocrinology 113, 1250-1260, 1983.
72.
F. Payvar D. DeFranco, G.L. Firestone, B. Edgar, Ö. Wrange, S Okret, J.-Å. Gustafsson
and K.R. Yamamoto: Sequence-specific binding of glucocorticoid receptor to MTV
DNA at sites within and upstream of the transcribed region. Cell 35, 381-392, 1983.
73.
L. Poellinger, J. Lund, M. Gillner, L.-A. Hansson and J.-Å. Gustafsson: Physicochemical
characterization of specific and nonspecific polyaromatic hydrocarbon binders in rat and
mouse liver cytosol. J. Biol. Chem. 258, 13535-13542, 1983.
74.
T. Saartok, E. Dahlberg and J.-Å. Gustafsson: Relative binding affinity of anabolicandrogenic steroids. Comparison of the binding to the androgen receptors in skeletal
muscle and in prostate, as well as to sex hormone-binding globulin. Endocrinology 114,
2100-2106, 1984.
75.
E. Dahlberg, A. Thalén, R Brattsand, J.-Å. Gustafsson, U. Johansson, K. Roempke and
T. Saartok: Correlation between chemical structure, receptor binding, and biological
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activity of some novel, highly active, 16,17-acetal-substituted glucocorticoids. Mol.
Pharmacol. 25, 70-78, 1984.
76.
L. Haglund, C. Köhler, T. Haaparanta, M. Goldstein and J.-Å. Gustafsson: Presence of
NADPH-cytochrome P-450 reductase in central catecholaminergic neurones. Nature 307,
259-262, 1984.
77.
S. Okret, A.-C. Wikström, Ö. Wrange, B. Andersson and J.-Å. Gustafsson: Monoclonal
antibodies against the rat liver glucocorticoid receptor. Proc. Natl. Acad. Sci. USA 81,
1609-1613, 1984.
78.
T. Haaparanta, H. Glaumann and J.-Å. Gustafsson: Characterization and endocrine
regulation of the cytochrome P-450 dependent microsomal hydroxylation of 5androstane-3,17-diol in the rat ventral prostate. Endocrinology 114, 2293-2300, 1984.
79.
Ö. Wrange, S. Okret, M. Radojcic, J. Carlstedt-Duke and J.-Å. Gustafsson:
Characterization of the purified activated glucocorticoid receptor from rat liver cytosol. J.
Biol. Chem. 259, 4534-4541, 1984.
80.
J. Bakke and J.-Å. Gustafsson: Mercapturic acid pathway metabolites of xenobiotics:
generation of potentially toxic metabolites during enterohepatic circulation. TIPS 5, 517521, 1984.
81.
G. Norstedt, G. Andersson and J.-Å. Gustafsson: Growth hormone induction of
lactogenic receptors at intracellular sites in male rat liver. Endocrinology 115, 672-680,
1984.
82.
R. Miesfeld, S. Okret, A.-C. Wikström, Ö. Wrange, J.-Å. Gustafsson and K. Yamamoto:
Characterization of a steroid receptor gene and mRNA in wild-type and mutant cells.
Nature 312, 779-781, 1984.
83.
C. MacGeoch, E.T. Morgan, J. Halpert and J.-Å. Gustafsson: Purification,
characterization and pituitary regulation of the sex-specific cytochrome P-450 15hydroxylase from liver microsomes of untreated female rats. J. Biol. Chem. 259, 1543315439, 1984.
84.
E.T. Morgan, C. MacGeoch and J.-Å. Gustafsson: Sexual differentiation of cytochrome
P-450 in rat liver. Evidence for a constitutive isozyme as the male-specific 16hydroxylase. Mol. Pharmacol. 27, 471-479, 1985.
85.
J. Bakke, C. Struble, J.-Å. Gustafsson and B. Gustafsson: Catabolism of premercapturic
acid pathway metabolites of naphthlene to naphthols and methylthio-containing
metabolites in rats. Proc. Natl. Acad. Sci. USA 82, 668-671, 1985.
86.
J. Lund, I. Brandt, L. Poellinger, Å. Bergman, E. Klasson-Wehler and J.-Å. Gustafsson:
Target cells for the polychlorinated biphenyl metabolite 4,4'-bis(methylsulfonyl)-2,2',5,5'tetrachlorobiphenyl. Characterization of high affinity binding in rat and mouse lung
cytosol. Mol. Pharmacol. 27, 314-323, 1985.
87.
L. Poellinger, J. Lund, E. Dahlberg and J.-Å. Gustafsson: A hydroxyl-apatite microassay
for receptor binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3-methylcholanthrene in
various target tissues. Anal. Biochem. 144, 371-384, 1985.
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88.
S. Okret, A.-C. Wikström and J.-Å. Gustafsson: Molybdate-stabilized glucocorticoid
receptor: evidence for a receptor heteromer. Biochemistry 24, 6581-6586, 1985.
89.
B. Husman, G. Andersson, G. Norstedt and J.-Å. Gustafsson: Characterization and
subcellular distribution of the somatogenic receptor in rat liver. Endocrinology 116,
2605-2611, 1985.
90.
C. MacGeoch, E.T. Morgan and J.-Å. Gustafsson: Hypothalamo-pituitary regulation of
cytochrome P-45015ß apoprotein levels in rat liver. Endocrinology 117, 2085-2092, 1985.
91.
M. Gillner, J. Bergman, C. Cambillau, B. Fernström and J.-Å. Gustafsson: Interactions of
indoles with specific binding sites for 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver.
Mol. Pharmacol. 28, 357-363, 1985.
92.
J.-O. Jansson, S. Ekberg, O. Isaksson, A. Mode and J.-Å. Gustafsson: Imprinting of
growth hormone secretion, body growth, and hepatic steroid metabolism by neonatal
testosterone. Endocrinology 117, 1881-1889, 1985.
93.
K. Fuxe, A.-C. Wikström, S. Okret, L.F. Agnati, A. Härfstrand, Z.-Y. Yu, L. Granholm,
M. Zoli, W. Vale and J.-Å. Gustafsson: Mapping of glucocorticoid receptor
immunoreactive neurons in the rat tel- and diencephalon using a monoclonal antibody
against rat liver glucocorticoid receptor. Endocrinology 117, 1803-1812, 1985.
94.
E.T. Morgan, C. MacGeoch and J.-Å. Gustafsson: Hormonal and developmental
regulation of expression of the hepatic microsomal steroid 16-hydroxylase cytochrome
P-450 apoprotein in the rat. J. Biol. Chem. 260, 11895-11898, 1985.
95.
S.H. Kaufmann, S. Okret, A.-C. Wikström, J.-Å. Gustafsson and J.H. Shaper: Binding of
the glucocorticoid receptor to the rat liver nuclear matrix. J. Biol. Chem. 261, 1196211967, 1986.
96.
S. Okret, L. Poellinger, Y. Dong and J.-Å. Gustafsson: Down-regulation of
glucocorticoid receptor mRNA by glucocorticoid hormones and recognition by the
receptor of a specific binding sequence within a receptor cDNA clone. Proc. Natl.
Acad.Sci. USA 83, 5899-5903, 1986.
97.
R. Miesfield, S. Rusconi, P.J. Godowski, B.A. Maler, S. Okret, A.-C. Wikström, J.-Å.
Gustafsson and K.R. Yamamoto: Genetic complementation of a glucocorticoid receptor
deficiency by expression of cloned receptor cDNA. Cell 46, 389-399, 1986.
98.
Ö. Wrange, J. Carlstedt-Duke and J.-Å. Gustafsson: Stoichiometric analysis of the
specific interaction of the glucocorticoid receptor with DNA. J. Biol. Chem. 261, 1177011778, 1986.
99.
A. Härfstrand, K. Fuxe, A. Cintra, L.F. Agnati, I. Zini, A.-C. Wikström, S. Okret, Z.-Y.
Yu, M. Goldstein, H. Steinbusch, A. Verhofstad and J.-Å. Gustafsson: Glucocorticoid
receptor immunoreactivity in monoaminergic neurons of rat brain. Proc. Natl. Acad. Sci.
USA 83, 9779-9783, 1986.
100.
J. Carlstedt-Duke, P.-E. Strömstedt, Ö. Wrange, T. Bergman, J.-Å. Gustafsson: Domain
structure of the glucocorticoid receptor protein. Proc. Natl. Acad. Sci. USA 84, 44374440, 1987.
12
101.
J.-Å. Gustafsson, J. Carlstedt-Duke, L. Poellinger, S. Okret, A.-C. Wikström, M.
Brönnegård, M. Gillner, Y. Dong, K. Fuxe, A. Cintra, A. Härfstrand and L. Agnati:
Biochemistry, molecular biology, and physiology of the glucocorticoid receptor.
Endocrine Reviews 8, 185-234, 1987.
102.
S. Cuthill, L. Poellinger and J.-Å. Gustafsson: The receptor for 2,3,7,8tetrachlorodibenzo-p-dioxin in the mouse hepatoma cell line Hepa 1c1c7. J. Biol. Chem.
262, 3477-3481, 1987.
103.
M. Brönnegård, L. Poellinger, S. Okret, A.-C. Wikström, O. Bakke and J.-Å. Gustafsson:
Characterization and sequence-specific binding to mouse mammary tumor virus DNA of
purified activated human glucocorticoid receptor. Biochemistry 26, 1697-1704, 1987.
104.
M. Denis, A.-C. Wikström and J.-Å. Gustafsson: The molybdate-stabilized non-activated
glucocorticoid receptor contains a dimer of Mr 90,000 non-hormone-binding protein. J.
Biol. Chem. 262, 11803-11806, 1987.
105.
L.-A. Haldosén and J.-Å. Gustafsson: Characterization of hepatic lactogen receptor. J.
Biol. Chem. 262, 7404-7411, 1987.
106.
A.-C. Wikström, O. Bakke, S. Okret, M. Brönnegård and J.-Å. Gustafsson: Intracellular
localization of the glucocorticoid receptor: Evidence for cytoplasmic and nuclear
localization. Endocrinology 120, 1204-1232, 1987.
107.
B. Husman, L.-A. Haldosén, G. Andersson and J.-Å. Gustafsson: Characterization of the
somatogenic receptor in rat liver. J. Biol. Chem. 263, 3963-3970, 1988.
108.
E.T. Morgan, M. Rönnholm and J.-Å. Gustafsson: Preparation and characterization of
monoclonal antibodies recognizing unique epitopes on sexually differentiated rat liver
cytochrome P-450 isozymes. Biochemistry 26, 4193-4200, 1987.
109.
M. Sundin, M. Warner, T. Haaparanta and J.-Å. Gustafsson: Isolation and catalytic
activity of cytochrome P-450 from ventral prostate of control rats. J. Biol. Chem. 262,
12293-12297, 1987.
110.
Y. Dong, L. Poellinger, S. Okret, J.-O. Höög, H. von Bahr-Lindström, H. Jörnvall and J.Å. Gustafsson: Regulation of gene expression of class I alcohol dehydrogenase by
glucocorticoids. Proc. Natl. Acad. Sci. USA 85, 767-771, 1988.
111.
B. Husman, L.-A. Haldosén, G. Andersson and J.-Å. Gustafsson: Characterization of the
somatogenic receptor in rat liver. J. Biol. Chem. 263, 3963-3970, 1988.
112.
A. Hecht, A. Berkenstam, P.-E. Strömstedt, J.-Å. Gustafsson and A.E. Sippel: A
progesterone responsive element maps to the far upstream steroid dependent DNase
hypersensitive site of chicken lysozyme chromatin. EMBO J. 7, 2063-2073, 1988.
113.
P.G. Zaphiropoulos, A. Mode, A. Ström, C. Möller, C. Fernandez and J.-Å. Gustafsson:
cDNA cloning, sequence, and regulation of a major female-specific and growth
hormone-inducible rat liver cytochrome P-450 active in 15-hydroxylation of steroid
sulfates. Proc. Natl. Acad. Sci. USA 85, 4214-4217, 1988.
13
114.
D.D. Sakai, S. Helms, J. Carlstedt-Duke, J.-Å. Gustafsson, F.M. Rottman and K.R.
Yamamoto: Hormone-mediated repression: a negative glucocorticoid response element
from the bovine prolactin gene. Genes & Development 2, 1144-1154, 1988.
115.
J. Carlstedt-Duke, P.-E. Strömstedt, B. Persson, E. Cederlund, J.-Å. Gustafsson and H.
Jörnvall: Identification of hormone-interacting amino acid residues within the steroidbinding domain of the glucocorticoid receptor in relation to other steroid hormone
receptors. J. Biol. Chem. 263, 6843-6846, 1988.
116.
M. Denis, L. Poellinger, A.-C. Wikström and J.-Å. Gustafsson: Requirement of hormone
for thermal conversion of the glucocorticoid receptor to a DNA-binding state. Nature 33,
686-688, 1988.
117.
J. Lund, L. Nordlund and J.-Å. Gustafsson: Partial purification of a binding protein for
polychlorinated biphenyls from rat lung cytosol: physicochemical and immunochemical
characterization. Biochemistry 27, 7895-7901, 1988.
118.
A. Berkenstam, H. Glaumann and J.-Å. Gustafsson: Unspecific and sequence-specific
deoxyribonucleic acid binding of the partially purified human progesterone receptor.
Mol. Endocrinol. 2, 571-578, 1988.
119.
S.Y. Tsai, J. Carlstedt-Duke, N.L. Weigel, K. Dahlman, J.-Å. Gustafsson, M.-J. Tsai and
B.W. O'Malley: Molecular interactions of steroid hormone receptor with its enhancer
element: evidence for receptor dimer formation. Cell 55, 361-369, 1988.
120.
P.S. Guzelian, D. Li, E.G. Schuetz, P. Thomas, W. Levin, A. Mode and J.-Å. Gustafsson:
Sex change in cytochrome P-450 phenotype by growth hormone treatment of adult rat
hepatocytes maintained in a culture system on matrigel. Proc. Natl. Acad. Sci. USA 85,
9783-9787, 1988.
121.
B.M.A. Näslund, H. Glaumann, M. Warner, J.-Å. Gustafsson and T. Hansson:
Cytochrome P-450 b and c in the rat brain and pituitary gland. Mol. Pharmacol., 33, 3137, 1988.
122.
M. Aronsson, K. Fuxe, Y. Dong, L.F. Agnati, S. Okret and J.-Å. Gustafsson:
Localization of glucocorticoid receptor mRNA in the male rat brain by in situ
hybridization. Proc. Natl. Acad. Sci. USA 85, 9331-9335, 1988.
123.
Y. Dong, L. Poellinger, J.-Å. Gustafsson and S. Okret: Regulation of glucocorticoid
receptor expression: evidence for transcriptional and posttranslational mechanisms. Mol.
Endocrinol. 2, 1256-1264, 1988.
124.
M. Denis, J.-Å. Gustafsson and A.-C. Wikström: Interaction of the Mr ≈90,000 heat
shock protein with the steroid-binding domain of the glucocorticoid receptor. J. Biol.
Chem. 263, 18520-18523, 1988.
125.
J. Hapgood, S. Cuthill, M. Denis, L. Poellinger and J.-Å. Gustafsson: Specific proteinDNA interactions at a xenobiotic-responsive element: copurification of dioxin receptor
and DNA-binding activity. Proc. Natl. Acad. Sci. USA 86, 60-64, 1989.
126.
B. Husman, J.-Å. Gustafsson and G. Andersson: Biogenesis of the somatogenic receptor
in rat liver. J. Biol. Chem. 264, 690-697, 1989.
14
127.
K. Dahlman, P.-E. Strömstedt, C. Rae, H. Jörnvall, J.-I. Flock, J. Carlstedt-Duke and J.Å. Gustafsson: High level expression in Escherichia coli of the DNA-binding domain of
the glucocorticoid receptor in a functional form utilizing domain-specific cleavage of a
fusion protein. J. Biol. Chem. 264, 804-809, 1989
128.
A. Berkenstam, H. Glaumann, M. Martin, J.-Å. Gustafsson and G. Norstedt: Hormonal
regulation of estrogen receptor messenger ribonucleic acid in T47Dco and MCF-7 breast
cancer cells. Mol. Endocrinol. 3, 22-28, 1989.
129.
M. Denis and J.-Å. Gustafsson: Translation of glucocorticoid receptor mRNA in vitro
yields a nonactivated protein. J. Biol. Chem. 264, 6005-6008, 1989.
130.
P.G. Zaphiropoulos, A. Mode, G. Norstedt and J.-Å. Gustafsson: Regulation of sexual
differentiation in drug and steroid metabolism. Trends in Pharmacological Sciences, 10,
149-153, 1989.
131.
M. Warner, M. Strömstedt, L. Möller and J.-Å. Gustafsson: Distribution and regulation
of 5-androstane-3,17-diol hydroxylase in the rat central nervous system.
Endocrinology 124, 1246-2699, 1989.
132.
Y. Dong, M. Aronsson, J.-Å. Gustafsson and S. Okret: The mechanism of cAMPinduced glucocorticoid receptor expression. Correlation to cellular glucocorticoid
response. J. Biol. Chem. 23, 13679-13686, 1989.
133.
A. Mode, E. Wiersma-Larsson and J.-Å. Gustafsson: Transcriptional and
posttranscriptional regulation of sexually differentiated rat liver cytochrome P-450 by
growth hormone. Mol. Endocrinol. 3, 1142-1147, 1989.
134.
P. Hagmar, K. Dahlman, M. Takahashi, J. Carlstedt-Duke, J.-Å. Gustafsson and B.
Nordén: Unspecific DNA binding of the DNA binding domain of the glucocorticoid
receptor studied with flow linear dichroism. FEBS Lett. 353, 28-32, 1989.
135.
T. Nemoto, G.G.F. Mason, A. Wilhelmsson, S. Cuthill, J. Hapgood, J.-Å. Gustafsson and
L. Poellinger: Activation of the dioxin and glucocorticoid receptors to a DNA binding
state under cell-free conditions. J. Biol. Chem. 265, 2269-2277, 1990.
136.
P.G. Zaphiropoulos, S. Westin, A. Ström, A. Mode and J.-Å. Gustafsson: Structural and
regulatory analysis of a cytochrome P-450 gen (CYP2C12) expressed predominantly in
female rat liver. DNA Cell Biol. 9, 49-56, 1990.
137.
P.G. Zaphiropoulos, A. Ström, J.A. Robertson and J.-Å. Gustafsson: Structural and
regulatory analysis of the male-specific rat liver cytochrome P-450g: Repression by
continuous growth hormone administration. Mol. Endocrinol. 4, 53-58, 1990.
138.
T. Nemoto, Y. Ohara-Nemoto, M. Denis and J.-Å. Gustafsson: The transformed
glucocorticoid receptor has a lower steroid-binding affinity than the nontransformed
receptor. Biochemistry 29, 1880-1886, 1990.
139.
A. Wilhelmsson, S. Cuthill, M. Denis, A.-C. Wikström, J.-Å. Gustafsson and L.
Poellinger: The specific DNA binding activity of the dioxin receptor is modulated by the
90 kd heat shock protein. EMBO J. 9, 69-76, 1990.
15
140.
Y. Dong, W. Cairns, S. Okret, and J.-Å. Gustafsson: A glucocorticoid-resistant rat
hepatoma cell variant contains functional glucocorticoid receptor. J. Biol. Chem. 265,
7526-7531, 1990.
141.
L. Nordlund-Möller, O. Andersson, R. Ahlgren, J. Schilling, M. Gillner, J.-Å. Gustafsson
and J. Lund: Cloning, structure, and expression of a rat binding protein for
polychlorinated biphenyls. J. Biol. Chem., 265, 12690-12693, 1990.
142.
P.-E. Strömstedt, A. Berkenstam, H. Jörnvall, J.-Å. Gustafsson and J. Carlstedt-Duke:
Radiosequence analysis of the human progestin receptor charged with [3H]Promegestone,
a comparison with the glucocorticoid receptor. J. Biol. Chem., 265, 12973-12977, 1990.
143.
E. Imai, P.-E. Strömstedt, P. G. Quinn, J. Carlstedt-Duke, J.-Å. Gustafsson and D. K.
Granner: Characterization of a complex glucocorticoid response unit in the
phosphoenolpyruvate carboxykinase gene. Mol.Cell. Biol., 10, 4712-4719, 1990.
144.
G. M. Howell, J.-Å. Gustafsson, and Y. A. Lefebvre: Glucocorticoid receptor identified
on nuclear envelopes of male rat livers by affinity labeling and immunochemistry.
Endocrinology, 127, 1087-1096, 1990.
145.
M. Brönnegård, P. Arner, L. Hellström, G. Akner, and J.-Å. Gustafsson: Glucocorticoid
receptor messenger ribonucleic acid in different regions of human adipose tissue.
Endocrinology, 127, 1689-1696, 1990.
146.
K. Dahlman-Wright, H. Siltala-Roos, J. Carlstedt-Duke, and J.-Å. Gustafsson: Proteinprotein interactions facilitate DNA binding by the glucocorticoid receptor DNA-binding
domain. J. Biol. Chem., 265, 14030-14035, 1990.
147.
J. A. Robertson, L.-A. Haldosén, T. J. J. Wood, M. K. Steed, and Jan-Åke Gustafsson:
Growth hormone pretranslationally regulates the sexually dimorphic expressio of the
prolactin receptor gene in rat liver. Mol. Endocrinol., 4, 1235-1239, 1990.
148.
T. Härd, K. Dahlman, J. Carlstedt-Duke, J.-Å Gustafsson and R. Rigler: Cooperativity
and specificity in the interactions between DNA and the glucocorticoid recptor DNAbinding domain. Biochemistry, 29, 5358-5364, 1990.
149.
T. Härd, E. Kellenbach, R. Boelens, B. A. Maler, K. Dahlman, L. P. Freedman, J.
Carlstedt-Duke, K. R. Yamamoto, J.-Å. Gustafsson, and R. Kaptein: Solution structure
of the glucocorticoid receptor DNA-binding domain. Science, 249, 157-160, 1990.
150.
S. Westin, A. Ström, J.-Å. Gustafsson, and P. G. Zaphiropoulos: Growth hormone
regulation of the cytochrome P-450IIC subfamily in the rat: Inductive, repressive, and
transcriptional effects on P-450f (IIC7) and P-450PB1 (IIC6) gene expression. Mol.
Pharmacol., 38, 192-197, 1990.
151.
T. Härd, E. Kellenbach, R. Kaptein, K. Dahlman, J. Carlstedt-Duke, L.P. Freedman, B.A.
Maler, E.I. Hyde, J.-Å. Gustafsson, and K.R. Yamamoto: 1H NMR studies of the
glucocorticoid receptor DNA-binding domain: sequential assignments and identification
of secondary structure elements. Biochemistry, 29, 9015-9023, 1990.
152.
M. Strömstedt, Shin-Ichi Hayashi, P.G. Zaphiropoulos, and J.-Å. Gustafsson: Cloning
and characterization of a novel member of the cytochrome P450 subfamily IVA in rat
prostate. DNA Cell Biol., 9, 569-577, 1990.
16
153.
L.A. Winter, M.J. Stewart, M.L. Shean, Y. Dong, L. Poellinger, S. Okret, J.-Å.
Gustafsson, and G. Duester: A hormone response element upstream from the human
alcohol dehydrogenase gene ADH2 consists of three tandem glucocorticoid receptor
binding sites. Gene, 91, 233-240, 1990.
154.
A.P.H. Wright, J. Carlstedt-Duke, and J.-Å. Gustafsson: Ligand-specific transactivation
of gene expression by a derivative of the human glucocorticoid receptor expressed in
yeast. J. Biol. Chem., 265, 14763-14769, 1990.
155.
P. Hess, T. Meenakshi, G. Chiu-Kai Chan, J. Carlstedt-Duke, J.-Å. Gustafsson, and F.
Payvar: Purified glucocorticoid receptors bind selectively in vitro to a cloned DNA
fragment that mediates a delayed secondary response to glucocorticoids in vivo. Proc.
Natl. Acad. Sci. USA 87, 2564-2568, 1990.
156.
M. Rebuffe-Scrive, M. Brönnegård, A. Nilsson, J. Eldh, J.-Å. Gustafsson, and P.
Björntorp: Steroid hormone receptors in human adipose tissue. J.Clin.Endocrinol. Metab.
71, 1215-1219, 1990.
157.
J. Zilliacus, K. Dahlman-Wright, A. Wright, J.-Å. Gustafsson, and J. Carlstedt-Duke:
DNA binding specificity of mutant glucocorticoid receptor DNA-binding domains. J.
Biol. Chem., 266, 3101-3106, 1991.
158.
C. Cairns, J.-Å. Gustafsson, and J. Carlstedt-Duke: Identification of protein contact sites
within the glucocorticoid/progestin response element. Mol. Endocrinol., 5, 598-604,
1991.
159.
M. Alksnis, T. Barkhem, P.-E. Strömstedt, H. Ahola, E. Kutoh, J.-Å. Gustafsson, L.
Poellinger and S. Nilsson: High level expression of functional full length and truncated
glucocorticoid receptor in chinese hamster ovary cells. J. Biol. Chem., 266, 1007810085, 1991.
160.
H. Tanaka, Y. Dong, Q. Li, S. Okret and J.-Å. Gustafsson: Identification and
characterization of a cis-acting element that interferes with glucocorticoid-inducible
activation of the mouse mammary tumor virus promoter. Proc.Natl.Acad.Sci. USA, 88,
5393-5397, 1991.
161.
P. Tollet, C. Legraverend, J.-Å. Gustafsson, and A. Mode: A role for protein kinases in
the growth hormone regulation of cytochrome P4502C12 and insulin-like growth factor-I
messenger RNA expression in primary adult rat hepatocytes. Mol. Endocrinol., 5, 13511358, 1991.
162.
J. Hapgood, S. Cuthill, P. Söderkvist, A. Wilhelmsson, I. Pongratz, R.H. Tukey, E. F.
Johnson, J.-Å. Gustafsson, and L. Poellinger: Liver cells contain constitutive DNase Ihypersensitive sites at the xenobiotic response elements 1 and 2 (XRE1 and -2) of the rat
cytochrome P-450IA1 gene and a constitutive, nuclear XRE-binding factor that is distinct
from the dioxin receptor. Mol. Cell. Biol., 11, 4314-4323, 1991.
163.
A.P.H. Wright and J.-Å. Gustafsson: Mechanism of synergistic transcriptional
transactivation by the human glucocorticoid receptor. Proc. Natl. Acad. Sci. USA, 88,
8283-8287, 1991.
17
164.
G. C.-K. Chan, P. Hess, T. Meenakshi, J. Carlstedt-Duke, J.-Å. Gustafsson and F.
Payvar: Delayed secondary glucocorticoid response elements. J. Biol.Chem. 266, 2263422644, 1991.
165.
H. Eguchi, S. Westin, A. Ström, J.-Å. Gustafsson, and P.G. Zaphiropoulos: Gene
structure and expression of the rat cytochrome P450IIC13, a polymorphic, male-specific
cytochrome in the P450IIC subfamily. Biochemistry, 30, 10844-10849, 1991.
166.
P.-E. Strömstedt, L. Poellinger, J.-Å. Gustafsson, and J. Carlstedt-Duke: The
Glucocorticoid Receptor Binds to a Sequence Overlapping the TATA Box of the Human
Osteocalcin Promoter: a Potential Mechanism for Negative Regulation. Mol. Cell. Biol,
11, 3379-3383, 1991.
167.
A.P.H. Wright, I.J. McEwan, K. Dahlman-Wright, and J.-Å. Gustafsson: High level
expression of the major transactivation domain of the human glucocorticoid receptor in
yeast cells inhibits endogenous gene expression and cell growth. Mol. Endocrinology.,5,
1366-1372, 1991.
168.
K. Dahlman-Wright, A. Wright, J.-Å. Gustafsson, and Jan Carlstedt-Duke: Interaction of
the glucocorticoid receptor DNA-binding domain with DNA as a dimer is mediated by a
short segment of five amino acids. J. Biol. Chem., 5, 3107-3112, 1991.
169.
L. Poellinger, M. Göttlicher and J.-Å. Gustafsson: The dioxin and peroxisome
proliferator-activated receptors: nuclear receptors in search of endogenous ligands. TIPS.
13, 241-245, 1992.
170.
S.H. Kaufmann, W.W. Wright, S. Okret, A.-C. Wikström, J.-Å. Gustafsson, N.L. Shaper,
and J.H. Shaper: Evidence that rodent epididymal sperm contain the Mr 94,000
glucocorticoid receptor but lack the Mr 90,000 heat shock protein. Endocrinology, 130,
3074-3084, 1992.
171.
M. Göttlicher, E. Widmark, Q. Li, and J.-Å. Gustafsson: Fatty acids activate a chimera of
the clofibric acid-activated receptor and the glucocorticoid receptor. Proc.Natl.Acad.Sci.
USA, 89, 4653-4657, 1992.
172.
A.P.H. Wright and J.-Å. Gustafsson: Glucocorticoid-specific gene activation by the intact
human glucocorticoid receptor expressed in yeast. J.Biol.Chem., 267, 11191-11195,
1992.
173.
M. Rudling, G. Norstedt, H. Olivecrona, E. Reihnér, J.-Å. Gustafsson and B. Angelin:
Importance of growth hormone for the induction of hepatic low density lipoprotein
receptors. Proc.Natl.Acad.Sci. USA, 89, 6983-6987, 1992.
174.
K. Dahlman-Wright, A.P. Wright, and J.-Å. Gustafsson: Determinants of high affinity
DNA-binding by the glucocorticoid receptor: Evaluation of receptor domains outside the
DNA-binding domain. Biochemistry, 31, 9040-9044, 1992.
175.
J. Zilliacus, A.P.H. Wright, U. Norinder, J.-Å. Gustafsson and J. Carlstedt-Duke:
Determinants for DNA-binding site recognition by the glucocorticoid receptor. J.of
Biol.Chem., 267, 24941-24947, 1992.
176.
S. Werner, M. Thorén, J.-Å. Gustafsson, and M. Brönnegård: Glucocorticoid receptor
abnormalities in fibroblasts from patients with idiopathic resistance to dexamethasone
18
diagnosed when evaluated for adrenocortical disorders. J. Endocrinol. Metab., 75, 10051009, 1992.
177.
C. Legraverend, A. Mode, T. Wells, I. Robinson, and J.-Å. Gustafsson: Hepatic steroid
hydroxylating enzymes are controlled by the sexually dimorphic pattern of growth
hormone secretion in normal and dwarf rats. FASEB J., 6, 711-718, 1992.
178.
C. Legraverend, A. Mode, S. Westin, A. Ström, H. Eguchi, P.G. Zaphiropoulos, and J.-Å.
Gustafsson: Transcriptional regulation of rat P-450 2C gene subfamily members by the
sexually dimorphic pattern of growth hormone secretion. Mol. Endocrinol., 6, 259-266,
1992.
179.
C.D. Banner, A. Goos-Nilsson, J. Sjövall, J.-Å. Gustafsson, and J. Rafter: A Method for
Characterization of Endogenous Ligands to Orphan Receptors Belonging to the Steroid
Hormone Receptor Superfamily - Isolation of Progesterone from Pregnancy Plasma
Using Progesterone Receptor Ligand-Binding Domain. Anal. Biochem., 200, 163-170,
1992.
180.
H. Berglund, H. Kovács, K. Dahlman-Wright, J.-Å. Gustafsson, and T. Härd: Backbone
dynamics of the glucocorticoid receptor DNA-binding domain. Biochemistry, 31, 1200112011, 1992.
181.
H. Baumann, K. Paulsen, H. Kovács, H. Berglund, A.P.H. Wright, J.-Å. Gustafsson, and
T. Härd: Refined solution structure of the glucocorticoid receptor DNA-binding domain.
Biochemistry, 32, 13463-13471, 1993.
182.
I.J. McEwan, A.P.H. Wright, K. Dahlman-Wright, J. Carlstedt-Duke, and J.-Å.
Gustafsson: Direct interaction of the 1 transactivation domain of the human
glucocorticoid receptor with the basal transcriptional machinery. Mol. Cell. Biol., 13,
399-407, 1993.
183.
K.L. Gearing, J.-Å. Gustafsson and S. Okret: Heterogeneity in the polyglutamine tract of
the glucocorticoid receptor from different rat strains. Nucleic Acids Res., 21, 2014, 1993.
184.
K. L. Gearing, M. Göttlicher, M. Teboul, E. Widmark, and J.-Å. Gustafsson: Interaction
of the peroxisome-proliferator-activated receptor and retinoid X receptor. Proc. Natl.
Acad. Sci. USA, 90, 1440-1444, 1993.
185.
M. Whitelaw, I. Pongratz, A. Wilhelmsson, J.-Å. Gustafsson, and L. Poellinger: Liganddependent recruitment of the arnt coregulator determines DNA recognition by the dioxin
receptor. Mol. Cell. Biol., 13, 2504-2514, 1993.
186.
A. Cintra, V. Solfrini, B. Bunnemann, S. Okret, F. Bortolotti, J.-Å. Gustafsson, and K.
Fuxe: Prenatal development of glucocorticoid receptor gene expression and
immunoreactivity in the rat brain and pituitary gland: A combined in situ hybridization
and immunocytochemical analysis. Neuroendocrinology, 57, 1133-1147, 1993.
187.
T. Lundbäck, C. Cairns, J.-Å. Gustafsson, J. Carlstedt-Duke, and T. Härd:
Thermodynamics of the glucocorticoid receptor-DNA interaction: Binding of wild-type
GR DBD to different response elements. Biochemistry, 32, 5074-5082, 1993.
188.
M. Gillner, J. Bergman, C. Cambillau, M. Alexandersson, B. Fernström, and J.-Å.
Gustafsson: Interactions of indolo[3,2-b]carbazoles and related polycyclic aromatic
19
hydrocarbons with specific binding sites for 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat
liver. Mol. Pharmacol., 44, 336-345, 1993.
189.
M. L. Whitelaw, M. Göttlicher, J.-Å. Gustafsson and L. Poellinger: Definition of a novel
ligand binding domain of a nuclear bHLH receptor: co-localization of ligand and hsp90
binding activities within the regulable inactivation domain of the dioxin receptor. EMBO
J., 12, 4169-4179, 1993.
190.
C.D. Banner, M. Göttlicher, E. Widmark, J. Sjövall, J.J. Rafter, and J.-Å. Gustafsson: A
systematic analytical chemistry/cell assay approach to isolate activators of orphan nuclear
receptor from biological extracts: characterization of peroxisome proliferator-activated
receptor activators in plasma. J. Lipid Res., 34, 1583-1591, 1993.
191.
H. Tanaka, Y. Dong, J. McGuire, S. Okret, L. Poellinger, I. Makino and J.-Å.
Gustafsson: The glucocorticoid receptor and a putative repressor protein coordinately
modulate glucocorticoid responsiveness of the mouse mammary tumor virus promoter in
the rat hepatoma cell line M1.19. J. Biol. Chem., 268, 1993.
192.
S. Westin, A. Mode, M. Murray, R. Chen, and J.-Å. Gustafsson: Growth hormone and
vitamin A induce P4502C7 mRNA expression in primary rat hepatocytes. Mol.
Pharmacol., 44, 997-1002, 1993.
193.
M. Strömstedt, M. Warner, C. D. Banner, P.C. Macdonald, and J.-Å. Gustafsson: Role of
brain cytochrome P450 in regulation of the level of anesthetic steroids in the brain. Mol.
Pharmacol., 44, 1077-1083, 1993.
194.
T. Härd and J.-Å. Gustafsson: Structure and function of the DNA-binding domain of the
glucocorticoid receptor and other members of the nuclear receptor supergene family.
Accounts of Chem. Res., 26, 644-650, 1993.
195.
G.G.F. Mason, A.-M. Witte, M.L. Whitelaw, C. Antonsson, J. McGuire, A.
Wilhelmsson, L. Poellinger and J.-Å. Gustafsson: Purification of the DNA binding form
of dioxin receptor. J. Biol. Chem., 269, 4438-4449, 1994.
196.
M.I. Kleman, L. Poellinger and J.-Å. Gustafsson: Regulation of human dioxin receptor
function by indolocarbazoles, receptor ligands of dietary origin. J. Biol. Chem., 269,
5137-5144, 1994.
197.
P. Tollet, M. Strömstedt, L. Frøyland, R.K. Berge and J.-Å. Gustafsson: Pretranslational
regulation of cytochrome P4504A1 by free fatty acids in primary cultures of rat
hepatocytes. J. Lipid. Res., 35, 248-254, 1994.
198.
M. Warner and J.-Å. Gustafsson: Effect of ethanol on cytochrome P450 in the rat brain.
Proc. Natl. Acad. Sci. USA., 91, 1019-1023, 1994.
199.
K. Dahlman-Wright, T. Almlöf, I.J. McEwan, J.-Å. Gustafsson and A.P.H. Wright:
Delineation of a small region within the major transactivation domain of the human
glucocorticoid receptor that mediates transactivation of gene expression. P. Natl. Acad.
Sci. USA. 91, 1619-1623, 1994.
200.
J. Zilliacus, J. Carlstedt-Duke, J.-Å. Gustafsson and A.P.H. Wright: Evolution of distinct
DNA-binding specificities within the nuclear receptor family of transcription factors.
Proc.Natl. Acad. Sci. USA., 91, 4175-4179, 1994.
20
201.
T. Lundbäck, J. Zilliacus, J.-Å. Gustafsson, J. Carlstedt-Duke and T. Härd:
Thermodynamics of sequence-specific glucocorticoid receptor-DNA interactions.
Biochemistry, 33, 5955-5965, 1994.
202.
A. Wilhelmsson, M.L. Whitelaw, J.-Å. Gustafsson and L. Poellinger: Agonistic and
antagonistic effects of -naphtoflavone on dioxin receptor function. J. Biol. Chem., 269,
19028-19033, 1994.
203.
J.-Å. Gustafsson: The hypothalamic-pituitary-liver axis growth hormone controls liver
sex. In The Liver: Biology and Pathobiology. Third Edition, edited by I. M. Arias, J.L.
Boyer, N. Fausto, W.B. Jakoby, D.A. Schachter and D.A. Shafritz. Raven Press, Ltd.,
New York, 1209-1215, 1994.
204.
J.-Å. Gustafsson: Regulation of sexual dimorphism in rat liver. In The Differences
between the Sexes. Edited by R.V. Short and E. Balaban, Cambridge University Press,
231-241, 1994.
205.
A. Cintra, M. Zoli, L. Rosén, L.F. Agnati, S. Okret, A.-C. Wikström, J.-Å. Gustafsson
and K. Fuxe: Mapping and computer assisted morphometry and microdensitometry of
glucocorticoid receptor immunoreactive neurons and glial cells in the rat central nervous
system. Neuroscience, 62, 843-897, 1994.
206.
J. McGuire, M.L. Whitelaw, I. Pongratz, J.-Å. Gustafsson and L. Poellinger: A cellular
factor stimulates ligand-dependent release of hsp90 from the basic helix-loop-helix
dioxin receptor. Mol. Cell. Biol. 14, 2438-2446, 1994.
207.
I. J. McEwan, T. Almlöf, A.-C. Wikström, K. Dahlman-Wright, A. P. H. Wright and J.Å. Gustafsson: The glucocorticoid receptor functions at multiple steps during
transcription initiation by RNA polymerase II. J. Biol.Chem. 269, 25629-25636, 1994.
208.
M. Whitelaw, J.-Å. Gustafsson, and L. Poellinger: Identification of transactivation and
repression functions of the dioxin receptor and its basic helix-loop-helix/PAS partner
factor Arnt: Inducible versus constitutive modes of regulation. Mol. Cell. Biol. 14, 83438355, 1994.
209.
J. Zilliacus, A.P.H. Wright, J. Carlstedt-Duke, and J.-Å. Gustafsson: Structural
determinants of DNA-binding specificity by steroid receptors. Mol. Endocrinol. 9, 389400, 1995.
210.
H. E. Witkowska, C. H. L. Shackleton, K. Dahlman-Wright, J. Y. Kim, and J.-Å.
Gustafsson: Mass spectrometric analysis of a native zinc-finger structure: The
glucocorticoid receptor DNA binding domain. J. Am. Chem. Society, 117, 3319-3324,
1995.
211.
M. Teboul, E. Enmark, Q. Li, A.C. Wikström, M. Pelto-Huikko, and J.-Å. Gustafsson:
OR-1, a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic
acid receptor. Proc. Natl. Acad. Sci. USA, 92, 2096-2100, 1995.
212.
J. Zilliacus, A. P. H. Wright, J. Carlstedt-Duke, L. Nilsson, and J.-Å. Gustafsson:
Modulation of DNA-binding specificity within the nuclear receptor family by
substitutions at a single amino acid position. Proteins: Structure, Function, and Genetics,
21, 57-67, 1995.
21
213.
C. Antonsson, M.L. Whitelaw, J. McGuire, J.-Å. Gustafsson, and L. Poellinger: Distinct
roles of the molecular chaperone hsp90 in modulating dioxin receptor function via the
basic helix-loop-helix and PAS domains. Mol. Cell. Biol. 15, 756-765, 1995.
214.
E. Caldenhoven, J. Lidén, S. Wissink, A. Van de Stolpe, J. Raaijmakers, L. Koenderman,
S. Okret, J.-Å. Gustafsson, and P. T. Van der Saag: Negative cross-talk between ReIA
and the glucocorticoid receptor: A possible mechanism for the antiinflammatory action of
glucocorticoids. Mol. Endocrinol. 9, 401-412, 1995.
215.
A. Ström, S. Westin, H. Eguchi, J.-Å. Gustafsson and A. Mode: Characterization of
orphan nuclear receptor binding elements in sex-differentiated members of the CYP2C
gene family expressed in rat liver. J. Biol. Chem., 270, 11276-11281, 1995.
216.
K. Dahlman-Wright, H. Baumann, I. J. McEwan, T. Almlöf, A.P.H. Wright, J.-Å.
Gustafsson, and T. Härd: Structural characterization of a minimal functional
transactivation domain from the human glucocorticoid receptor. Proc.Natl.Acad.Sci.
USA, 92, 1699-1703, 1995.
217.
T. J.J. Wood, D. Sliva, P. E. Lobie, T. J. Pircher, F. Gouilleux, H. Wakao, J.-Å.
Gustafsson, B. Groner, G. Norstedt, and L.-A. Haldosén: Mediation of growth hormonedependent transcriptional activation by mammary gland factor/stat 5. J.Biol. Chem., 270,
9448-9453, 1995.
218.
K. Grandien, M. Bäckdahl, Ö. Ljunggren, J.-Å. Gustafsson and A. Berkenstam: Estrogen
target tissue determines alternative promoter utilization of the human estrogen receptor
gene in osteoblasts and tumor cell lines. Endocrinology, 136, 2223-2229, 1995.
219.
P. Tollet, M. Hamberg, J.-Å. Gustafsson, and A. Mode: Growth hormone signaling
leading to CYP2C12 gene expression in rat hepatocytes involves phospholipase A2.
J.Biol. Chem., 270, 12569-12577, 1995.
220.
T. Almlöf, A.P.H. Wright and J.-Å. Gustafsson: Role of acidic and phoshorylated
residues in gene activation by the glucocorticoid receptor. J. Biol. Chem. 270, 1-6, 1995.
221.
M. Warner and J.-Å. Gustafsson: Cytochrome P450 in the brain: Neuroendocrine
functions. Frontiers in Neuroendocrinology, 16, 224-236, 1995.
222.
M. L. Whitelaw, J. McGuire, D. Picard, J.-Å. Gustafsson and L. Poellinger: Heat shock
protein hsp90 regulates dioxin receptor function in vivo. Proc. Natl. Acad. Sci. USA, 92,
4437-4441, 1995.
223.
A. Wyss, J.-Å. Gustafsson and M. Warner: Cytochromes P450 of the 2D subfamily in
rat brain. Mol. Pharmacol., 47, 1148-1155, 1995.
224.
H. Tanaka, Y. Makino, K. Dahlman-Wright, J.-Å. Gustafsson, K. Okamuto, and I.
Makino: Zinc ions antagonize the inhibitory effect of aurothiomalate on glucocorticoid
receptor function at physiological concentrations. Mol. Pharmacol., 48, 938-945, 1995.
225.
H. Hellmold, J. G. Lamb, A. Wyss, J.-Å. Gustafsson and M. Warner: Developmental and
endocrine regulation of P450 isoforms in rat breast. Mol. Pharmacol. 48, 630-638, 1995.
22
226.
P. Coumailleau, L. Poellinger, J.-Å. Gustafsson and M. L. Whitelaw: Definition of a
minimal domain of the dioxin receptor that is associated with Hsp90 and maintains wild
type ligand binding affinity and specificity. J. Biol.Chem. 270, 25291-25300, 1995.
227.
T. Härd, H.J. Barnes, C. Larsson, J.-Å. Gustafsson and J. Lund: Solution structure of a
mammalian PCB-binding protein in complex with a PCB. Nature Struct. Biol.2, 983-989,
1995.
238.
J.-Q. Chen, A. Ström, J.-Å. Gustafsson and E.T. Morgan: suppression of the constitutive
expression of cytochrome P-450 2C11 by cytokines and interferons in primary cultures of
rat hepatocytes: Comparison with induction of acute-phase genes and demonstration that
CYP2C11 promoter seqences are involved in the suppressive response to interleukins 1
and 6. Mol. Pharmacol. 47, 940-947, 1995.
229.
J. McGuire, P. Coumailleau, M.L. Whitelaw, J.-Å. Gustafsson and L. Poellinger: The
basic helix-loop-helix/PAS factor Sim is associated with hsp90. J. Biol. Chem. 270,
31353-31357, 1995.
230.
P. Tollet, O. Lahuna, R. Ahlgren, A. Mode, and J.-Å. Gustafsson: CCAAT/enhancerbinding protein--dependent transactivation of CYP2C12 in rat hepatocytes. Mol.
Endocrinol., 9, 1771-1781, 1995.
231.
H. Tanaka, Y. Makino, K. Dahlman-Wright, J.-Å. Gustafsson, K. Okamoto, and I.
Makino: Zinc ions antagonize the inhibitory effect of aurothiomalate on glucocorticoid
receptor function at physiological concentrations. Mol. Pharmacol. 48, 938-945, 1995.
232.
H. J. Barnes, L. Nordlund-Möller, M. Nord, O. Andersson, J.-Å. Gustafsson, J. Lund and
M. Gillner: Structural basis for calcium binding by uteroglobins. J. Mol. Biol. 256, 392404, 1996.
233.
G.G.J.M. Kuiper, E. Enmark, M. Pelto-Huikko, S. Nilsson, and J.-Å. Gustafsson:
Cloning of a novel estrogen receptor expressed in rat prostate and ovary.
Proc.Natl.Acad.Sci. USA 93, 5925-5930, 1996.
234.
E. Hedlund, A. Wyss, T. Kainu, M. Backlund, C. Köhler, M. Pelto-Huikko, J.-Å.
Gustafsson and M. Warner: Cytochrome P4502D4 in the brain: Specific neuronal
regulation by clozapine and toluene. Mol.Pharmacol. 50, 342-350, 1996.
235.
J.C. Rowlands, I.J. McEwan and J.-Å. Gustafsson: Trans-activation by the human aryl
hydrocarbon receptor and aryl hydrocarbn receptor nuclear translocator protein: Direct
interactions with basal transcription factors. Mol.Pharm. 50, 538-548, 1996.
236.
U. Lind, J. Carlstedt-Duke, J.-Å. Gustafsson and A.P.H. Wright: Identification of single
amino acid substitutions of cys-736 that affect the steroid-binding affinity and specificity
of the glucocorticoid receptor using phenotypic screening in yeast. Mol. Endocrinol. 10,
1358-1370, 1996.
237.
E. Enmark and J.-Å. Gustafsson: Orphan nuclear receptor - The first eight years. Mol.
Endocrinol. 10, 1293-1307, 1996.
238.
J.C. Corton, C. Bocos, E.S. Moreno, A. Merritt, D.S. Marsman, P.J. Sausen, R.C. Cattley
and J.Å. Gustafsson: Rat 17-hydroxysteroid dehydrogenase type IV is a novel
peroxisome proliferator-inducible gene. Mol. Pharmacol., 50, 1157-1166, 1996.
23
239.
G.G.J.M. Kuiper, B. Carlsson, K. Grandien, E. Enmark, J. Häggblad, S. Nilsson and J.Å. Gustafsson: Comparison of the ligand binding specificity and transcript tissue
distribution of estrogen receptors  and . Endocrinology., 138, 863-870, 1997.
240.
G. Spyrou, E. Enmark, A. Miranda-Vizuete, and J.-Å. Gustafsson: Cloning and
expression of a novel mammalian thioredoxin. J. Biol. Chem., 272, 2936-2941, 1997.
241.
T. Almlöf, J.-Å. Gustafsson, and A.P.H. Wright: Role of hydrophobic amino acid
clusters in the transactivation activity of the human glucocorticoid receptor. Mol. Cell
Biol., 17, 934-945, 1997.
242.
H. Wakui, A.P.H. Wright, J.-Å. Gustafsson, and J. Zilliacus: Interaction of the ligandactivated glucocorticoid receptor with the 14-3-3 protein. J. Biol. Chem. 272, 81538156, 1997.
243.
M. Byers, G.G.J.M. Kuiper, J.-Å. Gustafsson, and O.-K. Park-Sarge: Estrogen receptor-
mRNA expression in rat ovary: Down-regulation by gonadotropins. Mol. Endocrinol. 11,
172-182, 1997.
244.
I. McEwan, A.P.H. Wright and J.-Å. Gustafsson: Mechanism of gene expression by the
glucocorticoid receptor: role of protein-protein interactions. BioEssays, 19, 153-160,
1997.
245.
A. Henriksson, T. Almlöf, J. Ford, I.J. McEwan, J.-Å. Gustafsson and A.P.H. Wright:
Role of the Ada Adaptor Complex in Gene Activation by the Glucocorticoid Receptor.
Mol. Cell Biol. 3065-3073, 1997.
246.
J.C. Rowlands and J.-Å. Gustafsson: Aryl hydrocarbon receptor-mediated signal
transduction. Critical Rev. Toxicol., 27, 109-134, 1997.
247.
J.-Å. Gustafsson: Estrogen receptor - Getting in on the action? Nature Medicine, 3,
493-494, 1997.
248.
K. Pettersson, K. Grandien, G. G. J. M. Kuiper and J.-Å. Gustafsson: Mouse estrogen
receptor  forms estrogen response element binding heterodimers with estrogen receptor
. Mol. Endocrinol. 11, 1486-1496, 1997.
249.
K. Paech, P. Webb, G. G.J.M. Kuiper, S. Nilsson, J.-Å. Gustafsson, P. J.Kushner, and T.
S. Scanlan: Differential transactivation properties of the estrogen receptor isotypes (, ):
Estrogen-like effects with antiestrogens and antiestrogen effects with estrogen. Science,
277, 1508-1510, 1997.
250.
J. F. Couse, J. Lindzey, K. Grandien, J.-Å. Gustafsson and K.S. Korach: Tissue
distribution and quantitative analysis of estrogen receptor- (ER) and estrogen receptor (ER) mRNA in the wild-type and ER-knockout mouse. Endocrinology., 138, 46134621, 1997.
251.
A.M. Brzozowski, A.C.W. Pike, Z. Dauter, R.E. Hubbard, T. Bonn, O. Engström, L.
Öhman, G.L. Greene, J.-Å. Gustafsson and M. Carlquist: Insights into the molecular
basis of agonism and antagonism in the oestrogen receptor as revealed by complexes
with 17-oestradiol and raloxifene. Nature, 389, 753-758, 1997.
24
252.
J. Arts, G.G.J.M. Kuiper, J.M.M.F. Janssen, J.-Å. Gustafsson, C.W.G.M. Löwik, H.A.P.
Pols and J.P.T.M. van Leeuwen: Differential expression of estrogen receptor  and 
mRNA during human osteoblast differentiation. Endocrinology, 138, 5067-5070, 1997.
253.
K. Hecht, J. Carlstedt-Duke, P. Stierna, J.-Å. Gustafsson, M. Brönnegård and A.-C.
Wikström: Evidence that the -isoform of the human glucocorticoid receptor does not act
as a physiologically significant repressor. J. Biol. Chem., 272, 26659-26664, 1997.
254.
J. Lechner, T. Welte, J.K. Tomasi, P. Bruno, C. Cairns, J.-Å. Gustafsson and W.
Doppler: Promoter dependent synergy between glucocorticoid receptor and Stat5 in the
activation of -casein gene transcription. J. Biol. Chem. 272, 20954-20960, 1997.
255.
B. van der Burg, J. Lidén, S. Okret, F. Delaunay, S. Wissink, P.S. van der Saag, J.-Å.
Gustafsson: Nuclear Factor-Kappa-B Repression in Antiflammation and
Immunosuppression by Glucocorticoids. Trends Endocrinol. Metab.., 8, 152-157, 1997.
256.
H. Hellmold, T. Rylander, M. Magnusson, R.J. Edwards, E. Reihnér, M. Warner and J.Å. Gustafsson: Use of samples from reduction mammaplasties for characterization of the
P450 profile in human breast tissue. J. Clin. Endo. Metab. 83, 886-895, 1998.
257.
F.F. Wiebel, J.-Å. Gustafsson: Heterodimeric interaction between RXR and orphan
nuclear receptor OR1 reveals dimerization-induced activation as a novel mechanism of
nuclear receptor activation. Mol. Cell. Biol., 17, 3977-3986, 1997.
258.
I. McEwan and J.-Å. Gustafsson: Interaction of the human androgen receptor
transactivation function and TFIID. Proc.Natl.Acad.Sci. USA., 94, 8485-8490, 1997.
259.
J. Ford, I.J. McEwan, A.P.H. Wright and J.-Å. Gustafsson: Involvement of the TFIID
protein complex in gene activation by the N-terminal transactivation domain of the
glucocorticoid receptor in vitro. Mol.Endocrinol., 11, 1467-1475, 1997.
260.
F. Delaunay, A. Khan, A. Cintra, B. Davani, Z.-C. Ling, A. Andersson, C.-G. Östenson,
J.-Å. Gustafsson, S. Efendic, and S. Okret: Pancreatic -cells are important targets for the
diabetogenic effects of glucocorticoids. J. Clin. Invest. 100, 2094-2098, 1997.
261.
O. Lahuna, L. Fernandez, H. Karlsson, D. Maiter, F.P. Lemaigre, G. G. Rousseau, J.-Å.
Gustafsson and A. Mode: Expression of hepatocyte nuclear factor-6 in rat liver is sexdependent and regulated by growth hormone. Proc.Natl.Acad.Sci., USA, 94, 1230912313, 1997.
262.
G.S. Prins, M. Marmer, C. Woodham, W. Chang, G. Kuiper, J.-Å. Gustafsson, L. Birch:
Estrogen receptor beta mRNA ontogeny in the rat prostate and effects of neonatal
estrogen exposure on the expression pattern. Endocrinology 139, 874-883, 1998.
263.
A. Miranda-Vizuete, A. E. Damdimopoulos, J.-Å. Gustafsson and G. Spyrou: Cloning,
expression and characterization of a novel Escherichia coli thioredoxin. J.Biol.Chem.,
30841-30847, 1997.
264.
J. Lidén, F. Delaunay, I. Rafter, J.-Å. Gustafsson, and S. Okret: A new function for the
C-terminal zinc finger of the glucocorticoid receptor. J. Biol. Chem., 272, 21467-21472,
1997.
25
265.
Y. Yang, W.J. Griffiths, J. Sjövall, J.-Å. Gustafsson and J. Rafter: Liquid
chromatography-mass spectrometry with collision-induced dissociation of conjugated
metabolites of benzo[a]pyrene. J. Am. Soc. Mass. Spectrom., 8, 50-61, 1997.
266.
E. Enmark, M. Pelto-Huikko, K. Grandien, S. Lagercrantz, J. Lagercrantz, G. Fried, M.
Nordenskjöld and J.-Å. Gustafsson: Human estrogen receptor  -gene structure,
chromosomal localization and expression pattern. J. Clin. Endocrinol. Metab., 82, 42584265, 1997.
267.
H. Hellmold, M. Magnusson, M. Pelto-Huikko, J.-Å. Gustafsson and M. Warner:
Identification of CYP2A3 as a major cytochrome P450 enzyme in the female peripubertal
rat breast. Mol. Pharmacol., 53, 475-482, 1998.
268.
H. Nebb Sorensen, E. Treuter and J.-Å. Gustafsson: Regulation of peroxisome
proliferator-activated receptors (PPARs). Vitamins and Hormones, 54, 121-166, 1998.
269.
E. Treuter, T. Albrektsen, L. Johansson, J. Leers, and J.-Å. Gustafsson: A regulatory role
for RIP140 in nuclear receptor activation. Mol. Endocrinol., 12, 864-881, 1998.
270.
G.G.J.M. Kuiper, J.G. Lemmen, B. Carlsson, J.C. Corton, S.H. Safe, P. T. van der Saag,
B. van der Burg, and J.-Å. Gustafsson: Interaction of estrogenic chemicals and
phytoestrogens with estrogen receptor . Endocrinology, 139, 4252-4263, 1998.
271.
G.G.J.M. Kuiper, P.J. Shughrue, M. Pelto-Huikko, I. Merchenthaler and J.-Å.
Gustafsson: The estrogen receptor  subtype: A novel mediator of estrogen action in
neuroendocrine systems. Frontiers in Neuroendocrinol, 19, 253-286, 1998.
272.
C. Buggs, P. Tollet, H.-F. Zhao, N. Nasrin, A. Mode, J.-Å. Gustafsson, and M.
Alexander-Bridges: IRE-ABP, an SRY-like protein, inhibits C/EBP-stimulated
expression of the sex-specific cytochrome P450 2C12 gene. Mol. Endocrinol.., 12, 12941309, 1998.
273.
J.-Å. Gustafsson: Raloxifene: Magic bullet for heart and bone? Nature Medicine, 4, 152,
1998.
274.
S. Nilsson, G. Kuiper and J.-Å. Gustafsson: ER: a novel estrogen receptor offers the
potential for new drug development. Trends in Endocrinol. and Metabolism, 9, 387-395,
1998.
275.
G.S. Prins, M. Marmer, C. Woodham, W. Chang, G. Kuiper, J.-Å. Gustafsson, L. Birch:
Estrogen receptor beta mRNA ontogeny in the rat prostate and effects of neonatal
estrogen exposure on the expression pattern. Endocrinology, 139, 874-883, 1998.
276.
H. Hellmold, T. Rylander, M. Magnusson, R.J. Edwards, E. Reihnér, M. Warner and J.Å. Gustafsson: Use of samples from reduction mammaplasties for characterization of the
P450 profile in human breast tissue. J. Clin. Endo. Metab., 83, 886-895, 1998.
277.
E. Hedlund, J.-Å. Gustafsson and M. Warner: Cytochrome P450 in the brain: 2B or not
2B. TIPS, 19, 82-85, 1998.
278.
T. Barkhem, B. Carlsson, Y. Nilsson, E. Enmark, J.-Å. Gustafsson and S. Nilsson:
Differential response of estrogen receptor  and estrogen receptor  to partial estrogen
agonists/antagonists. Mol. Pharmacol., 54, 105-112, 1998.
26
279.
L. Fernández, A. Flores-Morales, O. Lahuna, D. Sliva, G. Norstedt, L.-A. Haldosén, A.
Mode and J.-Å. Gustafsson: Desensitization of the growth hormone induced JAK2/STAT
5 signaling pathway requires protein synthesis and phospholipase C. Endocrinology, 139,
1815-1824, 1998.
280.
J.-Å. Gustafsson: Therapeutic potential of selective estrogen receptor modulators.
Current Opinion in Chemical Biology, 2, 508-511, 1998.
281.
T. Almlöf, A. E. Wallberg, J.-Å. Gustafsson and A. P. H. Wright: Role of important
hydrophobic amino acids in the interaction between the glucocorticoid receptor 1-core
activation domain and target factors. Biochemistry, 37, 9586-9594, 1998.
282.
J.C. Corton, L.Q. Fan, S. Brown, C. Bocos, R.C. Cattley, A. Mode, and J.-Å. Gustafsson:
Down-regulation of cytochrome P450 2C family members and positive acute-phase
response gene expression by peroxisome proliferator chemicals. Mol. Pharmacol., 54,
463-473, 1998.
283.
G.G.J.M. Kuiper, M. Carlquist, and J.-Å. Gustafsson: Estrogen is a male and female
hormone. Science & Medicine, 5, 36-45, 1998.
284.
A.Dumont, S.P. Hehner, M.L. Schimtz, J.-Å. Gustafsson, J. Lidén, S. Okret, P. T. van
der Saag, S. Wissink, B. van der Burg, P. Herrlich, G. Haegeman, K. de Bosscher and W.
Fiers: Cross-talk between steroids and NF-B: what language? TIBS, 233-235, 1998.
285.
J. Leers, E. Treuter and J.-Å. Gustafsson: Mechanistic principles in NR box-dependent
interaction between nuclear hormone receptors and the coactivator TIF2. Mol. Cell. Biol.
18, 6001-6013, 1998.
286.
J. H. Krege, J. B. Hodgin, J. F. Couse, E. Enmark, M. Warner, J. F. Mahler, M. Sar, K. S.
Korach, J.-Å. Gustafsson, and O. Smithies: Generation and reproductive phenotypes of
mice lacking estrogen receptor . Proc.Natl.Acad.Sci. USA, 95, 15677-15682, 1998.
287.
Johansson, J. S. Thomsen, A. E. Damdimopoulos, G. Spyrou, J.-Å. Gustafsson, and E.
Treuter: The orphan nuclear receptor SHP inhibits agonist-dependent transcriptional
activity of estrogen receptors ER and ER. J. Biol. Chem., 247, 345-353, 1999.
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T.J. Pircher, H. Petersen, J.-Å. Gustafsson, and L.-A. Haldosén: Extracellular signal
regulated kinase (ERK) interacts with signal transducer and activator of transcription
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289.
A.M.M. van Pelt, D. G. de Rooij, B. van der Burg, P. T. van der Saag, J.-Å. Gustafsson,
and G.G.J.M. Kuiper: Ontogeny of estrogen receptor- expression in rat testis.
Endocrinology, 140, 478-483, 1999.
290.
J.R. Pedrajas, E. Kosmidou, A. Miranda-Vizuete, J.-Å. Gustafsson, A.P.H. Wright, and
G. Spyrou: Identification and functional characterization of a novel mitochondrial
thioredoxin system in Saccharomyces cerevisiae. J. Biol. Chem., 274, 6366-6373, 1999.
291.
E. Treuter, L. Johansson, J.S. Thomsen, A. Wärnmark, J. Leers, M. Pelto-Huikko, M.
Sjöberg, A.P.H. Wright, G. Spyrou, and J.-Å. Gustafsson: Competition between thyroid
hormone receptor-associated protein (TRAP) 220 and transcriptional intemediary factor
(TIF) 2 for binding to nuclear receptors. J. Biol. Chem., 274, 6667-6677, 1999.
27
292.
D. Feltkamp, F.F. Wiebel, S. Alberti, and J.-Å. Gustafsson: Identification of a novel
DNA binding site for nuclear orphan receptor OR1. J. Biol. Chem., 274, 10421-10429,
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293.
U. Lind, P. Greenidge, J.-Å. Gustafsson, A.P.H. Wright, and J. Carlstedt-Duke: Valine
571 functions as a regional organizer in programming the glucocorticoid receptor for
differential binding of glucocorticoids and mineralocorticoids. J. Biol. Chem., 274,
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294.
J.G. Lemmen, J.L.M. Broekhof, G.G.J.M. Kuiper, J.-Å. Gustafsson, P.T, van der Saag,
and B. van der Burg: Expression of estrogen receptor alpha and beta during mouse
embryogenesis. Mechanisms Development, 81, 163-167, 1999.
295.
R. Schultz, W. Yan, J. Toppari, A. Völkl, J.-Å. Gustafsson, and M. Pelto-Huikko:
Expression of peroxisome proliferator-activated receptor  messenger ribonucleic acid
and protein in human and rat testis. Endocrinology, 140, 2968-2975, 1999.
296.
F.F. Wiebel, K.R. Steffensen, E. Treuter, D. Feltkamp, and J.-Å. Gustafsson: Ligandindependent coregulator recruitment by the triply activatable OR1/Retinoid X receptor-
nuclear receptor heterodimer. Mol. Endocrinol., 13, 1105-1118, 1999.
297.
S. Mäkelä, H. Savolainen, E. Aavik, M. Myllärniemi, L. Strauss, E. Taskinen, J.-Å.
Gustafsson, and P. Häyry: Differentiation between vasculoprotective and uterotrophic
effects of ligands with different binding affinities to estrogen receptors  and . Proc.
Natl. Acad. Sci. USA, 96, 7077-7082, 1999.
298.
J.-Å. Gustafsson: Seeking ligands for lonely orphan receptors. Science, 284, 1285-1286,
1999.
299.
H.M. Guardiola-Diaz, S. Rehnmark, N.Usuda, T. Albrektsen, D. Feltkamp, J-Å.
Gustafsson, and S.E.H. Alexson: Rat peroxisome proliferator-activated receptors and
brown adipose tissue function during cold acclimatization. J. Biol. Chem., 274, 2336823377, 1999.
300.
J.-M. Vanacker, K. Pettersson, J.-Å. Gustafsson and V. Laudet: Transcriptional targets
shared by estrogen receptor-related receptors (ERRs) and estrogen receptor (ER) , but
not by ER. EMBO J. 18, 4270-4279, 1999.
301.
A. E. Wallberg, K. E. Neely, J.-Å. Gustafsson, J.L. Workman, A.P.H. Wright, and P.A.
Grant: Histone acetyltransferase complexes can mediate transcriptional activation by the
major glucocorticoid receptor activation domain. Mol. Cell. Biol., 19, 5952-5959, 1999.
302.
A.C.W. Pike, A.M. Brzozowski, R.E. Hubbard, T. Bonn, A.-G. Thorsell, O. Engström, J.
Ljunggren, J.-Å. Gustafsson and M. Carlquist: Structure of the ligand-binding domain of
oestrogen receptor beta in the presence of a partial agonist and a full antagonist. EMBO
J., 18, 4608-4618, 1999.
303.
P. Webb, P. Nguyen, C. Valentine, G. N. Lopez, G.R. Kwok, E. McInerney, B.S.
Katzenellenbogen, E. Enmark, J.-Å. Gustafsson, S. Nilsson, and P.J. Kushner: The
estrogen receptor enhances AP-1 activity by two distinct mechanisms with different
requirements for receptor transactivation functions. Mol. Endocrinol., 13, 1672-1685,
1999.
28
304.
S. Ogawa, J. Chan, A.E. Chester, J.-Å. Gustafsson, K.S. Korach, and D.W. Pfaff:
Survival of reproductive behaviors in estrogen receptor  gene-deficient (ERKO) male
and female mice. Proc.Natl.Acad.Sci.USA, 96, 12887-12892, 1999.
305.
L.D. Croce, S. Okret, S. Kersten, J.-Å. Gustafsson, M. Parker, W. Wahli and M. Beato:
Steroid and nuclear receptors. EMBO J., 18, 6201-6210, 1999.
306.
S.H Windahl, O. Vidal, G. Andersson, J.-Å. Gustafsson, and C. Ohlsson: Increased
cortical bone mineral content but unchanged trabecular bone mineral density in female
ER -/- mice. J. Clin. Invest., 104, 895-901, 1999.
307.
J. An, R.C. J Ribeiro, P. Webb, J.-Å. Gustafsson, P.J. Kushner, J.D. Baxter, and D.C.
Leitman: Estradiol repression of tumor necrosis factor- transcription requires estrogen
receptor activation function-2 and is enhanced by coactivators. Proc.Natl.Acad.Sci. USA,
96, 15161-15166, 1999.
308.
R.H. Karas, J. B. Hodgin, M. Kwoun, J.H. Krege, M. Aronovitz, W. Mackey, J.-Å.
Gustafsson, K.S. Korach, O. Smithies, and M.E. Mendelsohn. Estrogen inhibits the
vascular injury response in estrogen receptor  -deficient female mice. Proc.Natl.
Acad.Sci.USA, 96, 15133-15136, 1999.
309.
S. Saji, E. V. Jensen, S. Nilsson, T. Rylander, M. Warner, and J.-Å. Gustafsson: Estrogen
receptors  and  in the rodent mammary gland. Proc.Natl.Acad.Sci. USA, 97, 337-342,
2000.
310.
B. Saville, M. Wormke, F. Wang, T. Nguyen, E. Enmark, G. Kuiper, J.-Å. Gustafsson,
and S. Safe: Ligand-, cell-, and estrogen receptor subtype (/)-dependent activation at
GC-rich (Sp1) promoter elements. J. Biol. Chem. 275, 5379-5387, 2000.
311.
F. Caira, P. Antonson, M. Pelto-Huikko, E. Treuter, and J.-Å. Gustafsson: Cloning and
characterization of RAP250, a novel nuclear receptor coactivator. J. Biol. Chem. 275,
5308-5317, 2000.
312.
L. Johansson, A. Båvner, J.S. Thomsen, M. Färnegårdh, J.-Å. Gustafsson, and E. Treuter:
The orphan nuclear receptor SHP utilizes conserved LXXLL-related motifs for
interactions with ligand-activated estrogen receptors. Mol. Cell. Biol. 20, 1124-1133,
2000.
313.
C. Patrone, G. Pollio, E. Vegeto, E. Enmark, I. de Curtis, J.-Å. Gustafsson and A. Maggi:
Estradiol induces differential neuronal phenotypes by activating estrogen receptor  or .
Endocrinol., 141, 1839-1845, 2000.
314.
A. E. Wallberg, K. E. Neely, A. H. Hassan, J.-Å. Gustafsson, J. L. Workman and A.P.H.
Wright: Recruitment of the SWI-SNF chromatin remodeling complex as a mechanism of
gene activation by the glucocorticoid receptor 1 activation domain. Mol. Cell. Biol. 20,
2004-2013, 2000.
315.
O. Vidal, M. K. Lindberg, K. Hollberg, D. J. Baylink, G. Andersson, D. B. Lubahn, S.
Mohan, J.-Å. Gustafsson, and C. Ohlsson: Estrogen receptor specificity in the regulation
of skeletal growth and maturation in male mice. Proc.Natl.Acad.Sci. USA, 97, 54745479, 2000.
29
316.
K.A. Risan Tobin, H. Hermansen Steineger, S. Alberti, Ö. Spydevold, J. Auwerx, J.-Å.
Gustafsson, and H. I. Nebb: Cross-talk between fatty acid and cholesterol metabolism
mediated by liver X receptor-. Mol. Endo., 14, 741-752, 2000.
317.
Z. Weihua, S. Saji, S. Mäkinen, G. Cheng, E. V. Jensen, M. Warner and J.-Å.
Gustafsson: Estrogen receptor (ER) , a modulator of ER in the uterus.
Proc.Natl.Acad.Sci. USA, 97, 5936-5941, 2000.
318.
A. Wärnmark, J.-Å. Gustafsson, and A.P.H. Wright: Architectural principles for the
structure and function of the glucocorticoid receptor 1 core activation domain. J. Biol.
Chem. 275, 15014-15018, 2000.
319.
E. Enmark and J.-Å. Gustafsson: Nematode genome sequence dramatically extends the
nuclear receptor superfamily. TIPS, 21, 85-87, 2000.
320.
J. R. Pedrajas, A. Miranda-Vizuete, N. Javanmardy, J.-Å. Gustafsson, and G. Spyrou:
Mitochondria of Saccharomyces cerevisiae contan one-conserved cysteine type
peroxiredoxin with thioredoxin peroxidase activity. J. Biol. Chem. 275, 16296-16301,
2000.
321.
F. Delaunay, K. Pettersson, M. Tujague, and J.-Å. Gustafsson: Functional differences
between the amino-terminal domains of estrogen receptors  and . Mol. Pharmacol., 58,
584-590, 2000.
322.
C. S. Rosenfeld, P. S. Cooke, T. H. Welsh, Jr., G. Simmer, M. G. Hufford, J.-Å.
Gustafsson, R. A. Hess and D. B. Lubahn: The differential fate of mesonephric tubularderived efferent ductules in estrogen receptor- knockout versus wild-type female mice.
Endocrinology, 141, 3792-3798, 2000.
323.
C. Palmieri, S. Saji, J.-Å. Gustafsson, R C. Coombes: False negatives in oestrogenreceptor assay. The Lancet, 356, 944, 2000.
324.
M. K. Österlund, J.-Å. Gustafsson, E. Keller and Y. L. Hurd: Estrogen receptor  (ER)
messenger ribonucleic acid (mRNA) expression within the human forebrain: Distinct
distribution pattern to ER mRNA. J. Clin. Endocrin. & Metabol., 85, 3840-3846, 2000.
325.
K. Pettersson, F. Dalaunay, and J.-Å. Gustafsson: Estrogen receptor  acts as a dominant
regulator of estrogen signaling. Oncogene, 19, 4970-4978, 2000.
326.
K. Mikitani, T. Sugasaki, T. Shimada, M. Kobayashi, and J.-Å. Gustafsson: The chitinase
gene of the silkworm, Bombyx mori, contains a novel Tc-like transposable element. J.
Biol. Chem., 275, 37725-37732, 2000.
327.
C. M. Sadek, S. Jalaguier, E P. Feeney, M. Aitola, A. E. Damdimopoulos, M. PeltoHuikko, J.-Å. Gustafsson. Isolation and characterization of AINT: a novel ARNT
interacting protein expressed during murine embryonic development. Mechanisms of
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328.
C. Widén, J. Zilliacus, J.-Å. Gustafsson, and A.-C. Wikström. Glucocorticoid receptor
interaction with 14-3-3 and raf-1, a proposed mechanism for cross-talk of two signal
transduction pathways. J. Biol. Chem., 275, 39296-39301, 2000.
30
329.
A. Ström, N. Arai, J. Leers, and J.-Å. Gustafsson. The Hairy and Enhancer of Split
homologue-1 (HES-1) mediates the proliferative effect of 17-estradiol on breast cancer
cell lines. Oncogene, 19, 5951-5953, 2000.
330.
H. Zhang, J. S. Thomsen, L. Johansson, J.-Å. Gustafsson, and E. Treuter. DAX-1
functions as an LXXLL-containing corepressor for activated estrogen receptors. J. Biol.
Chem., 275, 39855-39859, 2000.
331.
S. Ogawa, A.E. Chester, S. Curtis Hewitt, V. R. Walker, J.-Å. Gustafsson, O. Smithies,
K.S. Korach, and D. W. Pfaff. Abolition of male sexual behaviors in mice lacking
estrogen receptors  and  (ERKO). Proc.Natl.Acad.Sci. USA, 97, 14737-14741, 2000.
332.
Y. Yang, W. J. Griffiths, M. Nordling, J. Nygren, L. Möller, J. Bergman, E. Liepinsh, G.
Otting, J.-Å. Gustafsson, J. Rafter, and J. Sjövall. Ring opening of benzo[a]pyrene in the
germ-free rat is a novel pathway for formation of potentially genotoxic metabolites.
Biochemistry, 39, 15585-15591, 2000.
333.
J. L. Temple, H. N. Fugger, X. Li, S. J. Shetty, J.-Å. Gustafsson & E. R. Rissman:
Estrogen receptor  regulates sexually dimorphic neural responses to estradiol.
Endocrinol., 142, 510-513, 2001.
334.
L. Wang, S. Andersson, M. Warner, and J.-Å. Gustafsson: Morphological abnormalities
in the brains of estrogen receptor  knockout mice. Proc.Natl.Acad.Sci. USA, 98, 27922796, 2001.
335.
M. E. Quaedackers, C. E. van den Brink, S. Wissink, R.H.M.M. Schreurs, J.-Å.
Gustafsson, P. T. van der Saag, and B. van der Burg: 4-hydroxytamoxifen trans-represses
nuclear factor-B activity in human osteoblastic U2-OS cells through estrogen receptor
(ER), and not through ER. Endocrinol. 142, 1156-1166, 2001.
336.
S. Alberti, G. Schuster, P. Parini, D. Feltkamp, U. Diczfalusy, M. Rudling, B. Angelin, I.
Björkhem, S. Pettersson, and J.-Å. Gustafsson: Hepatic cholesterol metabolism and
resistance to dietary cholesterol in LXR-deficient mice. J. Clin. Invest., 107, 565-573,
2001.
337.
K. Pettersson and J.-Å. Gustafsson: Role of estrogen receptor beta in estrogen action.
Annu. Rev. Physiol., 63, 165-92, 2001.
338.
J. Zilliacus, E. Holter, H. Wakui, H. Tazawa, E. Treuter and J.-Å. Gustafsson: Regulation
of glucocorticoid receptor activity by 14-3-3-dependent intracellular relocalization of the
corepressor RIP140. Mol. Endocrinol., 15, 501-511, 2001.
339.
W. Doppler, M. Windegger, C. Soratroi, J. Tomasi, J. Lechner, S. Rusconi, A.C.B. Cato,
T. Almlöf, J. Lidén, S. Okret, J.-Å. Gustafsson, H. Richard-Foy, D. B. Starr, H. Klocker,
D. Edwards, and S. Geymayer: Expression level-dependent contribution of glucocorticoid
receptor domains for functional interaction with STAT5. Mol. Cell. Biol., 21, 3266-3279,
2001.
340.
M. Elholm, I. Dam, C. Jörgensen, A.-M. Krogsdam, D. Holst, I. Kratchmarova, M.
Göttlicher, J.-Å. Gustafsson, R. Berge, T. Flatmark, J. Knudsen, S. Mandrup and K.
Kristiansen: Acyl-CoA esters antagonize the effects of ligands on peroxisome
31
proliferator-activated receptor  conformation, DNA binding, and interaction with cofactors. J. Biol. Cell., 276, 21410-21416, 2001.
341.
P. Roger, M. E. Sahla, S. Mäkelä, J.-Å. Gustafsson, P. Baldet, and H. Rochefort:
Decreased expression of estrogen receptor protein in proliferative preinvasive
mammary tumors. Cancer Res., 61, 2537-2541, 2001.
342.
A. C. W. Pike, A. M. Brzozowski, J. Walton, R. E. Hubbard, A.-G. Thorsell, Y.-L. Li, J.Å. Gustafsson, and M. Carlquist: Structural insights into the mode of action of a pure
antiestrogen. Structure, 9, 145-153, 2001.
343.
Z. Weihua, S. Mäkelä, L. C. Andersson, S. Salmi, S. Saji, J. I. Webster, E. V. Jensen, S.
Nilsson, M. Warner, and J.-Å. Gustafsson: A role for estrogen receptor  in the regulation
of growth of the ventral prostate. Proc.Natl.Acad.Sci. USA, 98, 6330-6335, 2001.
344.
K. Rose, A. Allan, S. Gauldie, G. Stapleton, L. Dobbie, K. Dott, C. Martin, L. Wang, E.
Hedlund, J. R. Seckl, J.-Å. Gustafsson, and R. Lathe: Neurosteroid hydroxylase CYP7B
vivid reporter activity in dentate gyrus of gene-targeted mice and abolition of a
widespread pathway of steroid and oxysterol hydroxylation. J. Biol. Chem., 276, 2393723944, 2001.
345.
S. Saji, H. Sakaguchi, S. Andersson, M. Warner, and J.-Å. Gustafsson: Quantitative
analysis of estrogen receptor proteins in rat mammary gland. Endocrinol. 142, 31773186, 2001.
346.
A. Wärnmark, T. Almlöf, J. Leers, J.-Å. Gustafsson, and E. Treuter: Differential
recruitment of the mammalian mediator subunit TRAP220 by estrogen receptor ER and
ER. J. Biol. Chem., 276, 23397-23404, 2001.
347.
L. G. Horvath, S. M.. Henshall, C.-S. Lee, D. R. Head, D. I. Quinn, S. Makela, W.
Delprado, D. Golovsky, P. C. Brenner, G. O’Neill, R. Kooner, P. D. Stricker, J. J.
Grygiel, J.-Å. Gustafsson, and R. L. Sutherland: Frequent loss of estrogen receptor-
expression in prostate cancer. Cancer Res., 61, 5331-5335, 2001.
348.
A. Miranda-Vizuete, J. Ljung, A. E. Damdimopoulos, J.-Å. Gustafsson, R. Oko, M.
Pelto-Huikko, and G. Spyrou: Characterization of Sptrx, a novel member of the
thioredoxin family specifically expressed in human spermatozoa. J. Biol. Chem., 276,
31567-31574, 2001.
349.
S.H. Windahl, K. Hollberg, O. Vidal, J.-Å. Gustafsson, C. Ohlsson, and G. Andersson:
Female estrogen receptor  -/- mice are partially protected against age-related trabecular
bone loss. J. Bone and Mineral Res., 16, 2001.
350.
R. H. Karas, H. Schulten, G. Pare, M. J. Aronvitz, C. Ohlsson, J.-Å. Gustafsson, M. E.
Mendelsohn: Effects of estrogen on the vascular injury response in estrogen receptor , 
(double) knockout mice. Circ Res.,89, 534-539, 2001.
351.
S. Nilsson, S. Mäkelä, E. Treuter, M. Tujague, J. Thomsen, G. Andersson, E. Enmark, K.
Pettersson, M. Warner, and J.-Å. Gustafsson: Mechanism of estrogen action. Phys. Rev.
81, 1535-1565, 2001.
352.
E. Enmark and J.-Å. Gustafsson: Comparing nuclear receptors in worms, flies and
humans. Trends Pharmacol. Sci., 22, 611-615, 2001.
32
353.
M. Hedengran Faulds, K. Pettersson, J.-Å. Gustafsson and L.-A. Haldosén: Cross-talk
between ERs and signal transducer and activator of transcription 5 is E2 dependent and
involves two functionally separate mechanisms. Mol. Endocrinol. 15, 1929-1940, 2001.
354.
E. V. Jensen, G. Cheng, C. Palmieri, S. Saji, S. Mäkelä, S. van Noorden, T. Wahlström,
M. Warner, R. C. Coombes, and J.-Å. Gustafsson: Estrogen receptors and proliferation
markers in primary and recurrent breast cancer. Proc.Natl.Acad.Sci. USA, 98, 1519715202, 2001.
355.
A. Wärnmark, A. Wikström, A. P. H. Wright, J.-Å. Gustafsson, and T. Härd: The Nterminal regions of estrogen receptor  and  are unstructured in vitro and show different
TBP binding properties. J. Biol. Chem. 276, 45939-45944, 2001.
356.
Y. Zhu, Z. Bian, P. Lu, R. H. Karas, L. Bao, D. Cox, J. Hodgin, P. W. Shaul, P. Thorén,
O. Smithies, J.-Å. Gustafsson, M. E. Mendelsohn: Abnormal vascular function and
hypertension in mice deficient in estrogen receptor . Science, 295, 505-508, 2002.
357.
P. Ciana, E. Vegeto, M. Beato, P. Chambon, J.-Å. Gustafsson, M. Parker, W. Wahli and
A. Maggi: Looking at nuclear receptor from the heights of Erice. Workshop on nuclear
receptor structure and function. EMBO reports., 31, 125-129, 2002.
358.
E. Holter, N. Kotaja, S. Mäkelä, L. Strauss, S. Kietz, O. A. Jänne, J.-Å. Gustafsson, J. J.
Palvimo, and E. Treuter: Inhibition of androgen receptor (AR) function by the
reproductive orphan nuclear receptor DAX-1. Mol. Endocrinol., 16, 515-528, 2002.
359.
C. Palmieri, G. J. Cheng, S. Saji, M. Zelada-Hedman, A. Wärri, Z. Weihua, S. Van
Noorden, T. Wahlstrom, R. C. Coombes, M. Warner, and J.-Å. Gustafsson: Estrogen
receptor beta in breast cancer. Endocrine-Related Cancer, 9, 1-13, 2002.
360.
E.F. Rissman, A. L. Heck, J. E. Leonard, M. A. Shupnik, and J.-Å. Gustafsson:
Disruption of estrogen receptor  gene impairs spatial learning in female mice.
Proc.Natl.Acad.Sci. USA, 99, 3996-4001, 2002.
361.
K. A. Risan Tobin, S. M. Ulven, G. U. Schuster, H. Hermansen Steineger, S. M.
Andresen, J.-Å. Gustafsson, and H. I. Nebb: Liver X receptors as insuling-mediating
factors in fatty acid and cholesterol biosynthesis. J. Biol. Chem., 277, 10691-10697,
2002.
362.
M. K. Lindberg, S. Movérare, S. Skrtic, S. Alatalo, J. Halleen, S. Mohan, J.-Å.
Gustafsson, and C. Ohlsson: Two different pathways for the maintenance of trabecular
bone in adult male mice. J. Bone Mineral Res, 17, 555-562, 2002.
363.
T. Barkhem, L.-A. Haldosen, J.-Å. Gustafsson and S. Nilsson: pS2 gene expression in
HepG2 cells: Complex regulation through crosstalk between the estrogen receptor alpha,
an estrogen-responsive element, and the activator protein 1 response element. Mol.
Pharmacol., 61, 1273-1283, 2002.
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S. H. Windahl, G. Andersson, and J.-Å. Gustafsson: Elucidation of estrogen receptor
function in bone with the use of mouse models. TEM, 13, 195-200, 2002.
365.
A. Wärnmark, E. Treuter, J.-Å. Gustafsson, R. E. Hubbard, A. M. Brzozowski, and A. C.
W. Pike: Interaction of transcriptional intermediary factor 2 nuclear receptor box peptides
33
with the coactivator binding site of estrogen receptor . J. Biol. Chem., 277, 2186221868, 2002.
366.
A. Båvner, L. Johansson, G. Toresson, J.-Å. Gustafsson, E. Treuter: A transcriptional
inhibitor targeted by the atypical orphan nuclear receptor SHP. EMBO reports, 5, 478484, 2002.
367.
L. Wang, S. Andersson, M. Warner and J.-Å. Gustafsson: Estrogen actions in the brain.
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T. M. Stulnig, U. Opperman, K. R. Steffensen, G. U. Schuster and J.-Å. Gustafsson:
Liver X receptor downregulates 11-hydroxysteroid dehydrogenase type 1 expression and
activity. Diabetes, 51, 2426-2433, 2002.
369.
H. Helander, J.-Å. Gustafsson, and A. Mode: Possible involvement of truncated signal
transducer and activator of transcription-5 in the GH pattern-dependent regulation of
CYP2C12 gene expression in rat liver. Mol. Endocrinol., 16, 1598-1611, 2002.
370.
P. Müller, S. Kietz, J.-Å. Gustafsson and A. Ström: The anti-estrogenic effect of alltrans-retinoic acid on the breast cancer cell line MCF-7 is dependent on HES-1
expression. J. Biol. Chem., 277, 28376-28379, 2002.
371.
G. U. Schuster, P. Parini, L. Wang, S. Alberti, K. R. Steffensen, G. K. Hansson, B.
Angelin, J.-Å. Gustafsson: Accumulation of foam cells in liver X receptor-deficient mice.
Circulation, 106, 1147-1153, 2002.
372.
S. Saji, Y. Omoto, C. Shimizu, M. Warner, Y. Hayashi, S.-I. Horiguchi, T. Watanabe, S.I. Hayashi, J.-Å. Gustafsson and M. Toi: Expression of estrogen receptor (ER) cx
protein in ER -positive breast cancer: specific correlation with progesterone receptor.
Cancer Res. 62, 4849-4853, 2002.
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S. Nilsson and J.-Å. Gustafsson: Biological role of estrogen and estrogen receptors.
Critical Rev. Biochem. Mol. Biol., 37, 1-28, 2002.
374.
L. Wang, G. U. Schuster, K. Hultenby, Q. Zhang, S. Andersson, and J.-Å. Gustafsson:
Liver X receptors in the central nervous system: From lipid homeostasis to neuronal
degeneration. Proc.Natl.Acad.Sci. USA, 99, 13878-13883, 2002.
375.
Z. Weihua, R. Lathe, M. Warner, and J.-Å. Gustafsson: An endocrine pathway in the
prostate, ER, AR, 5-androstane-3, 17-diol, and CYP7B1, regulates prostate growth.
Proc.Natl.Acad.Sci. USA, 99, 13589-13594, 2002.
376.
A. D. Schreihofer, D. F. Rowe, E. F. Rissman, E. M. Scordalakes, J.-Å. Gustafsson, and
M. A. Shupnik: Estrogen receptor  (ER), but not ER, modulates estrogen stimulation
of the ER-truncated variant, TERP-1, Endocrinol., 143, 4196-4202, 2002.
377.
T. M. Stulnig, K.R. Steffensen, H. Gao, M. Reimers, K. Dahlman-Wright, G. U.
Schuster, and J.-Å. Gustafsson: Novel roles of liver X receptors exposed by gene
expression profiling in liver and adipose tissue. Mol. Pharmacol., 62, 1299-1305, 2002.
34
378.
C. Förster, S. Mäkelä, A. Wärri, S. Kietz, D. Becker, K. Hultenby, M. Warner, and J.-Å.
Gustafsson: Involvement of estrogen receptor in terminal differentiation of mammary
gland epithelium. Proc. Natl. Acad. Sci. USA, 99, 15578-15583, 2002.
379.
T. Barkhem, L.-A. Haldosén, J.-Å. Gustafsson, and S. Nilsson: Transcriptional synergism
on the pS2 gene promoter between a p160 coactivator and estrogen receptor- depends on
the coactivator subtype, the type of estrogen response element, and the promoter context.
Mol. Endocrinol. 11, 2571-2581, 2002.
380.
L. Johansson Borgius, K. R. Steffensen, J.-Å. Gustafsson, E. Treuter: Glucocorticoid
signaling is perturbed by the atypical orphan receptor and corepressor SHP. J. Biol.
Chem., 277, 49761-49766, 2002.
381.
M.K. Lindberg, S. Movérare, A.-L. Eriksson, S. Skrtic, H. Gao, K. Dahlman-Wright, J.-Å
Gustafsson, and C. Ohlsson: Identification of estrogen-regulated genes of potential
importance for the regulation of trabecular bone mineral density. J. Bone & Min. Res.,
17, 2183-2195, 2002.
382.
L. Wang, S. Andersson, M. Warner, and J.-Å. Gustafsson: Estrogen receptor (ER)
knockout mice reveal a role for ER in migration of corticol neurons in the developing
brain. Proc. Natl. Acad. Sci. USA, 100, 703-708, 2003.
383.
S. Ogawa, J. Chan, J.-Å. Gustafsson, K. S. Korach, and D. W. Pfaff: Estrogen increases
locomotor activity in mice through estrogen receptor : Specificity for the type of
activity. Endocrinol. 144, 230-239, 2003.
384.
P. M. Cunnea, A. Miranda-Vizuete, G. Bertoli, T. Simmen, A. E. Damdimopoulos, S.
Hermann, S. Leinonen, M. Pelto-Huikko, J.-Å. Gustafsson, R. Sitia, and G. Spyrou:
Erdj5, an endoplasmic reticulum (ER)-resident protein containing DnaJ and thioredoxin
domains, is expressed in secretory cells or following ER stress. J. Biol. Chem. 278, 10591066, 2003.
385.
L. K. Juvet, S.M. Andresen, G.U. Schuster, K.T Dalen, K.A.R. Tobin, K. Hollung, F.
Haugen, S. Jacinto, S.M. Ulven, K. Bamberg, J.-Å. Gustafsson, and H. I. Nebb: On the
role of liver X receptor in lipid accumulation in adipocytes. Mol. Endocrinol. 17, 172182, 2003.
386.
M. K. Lindberg, S. Movérare, S. Skrtic, H. Gao, K. Dahlman-Wright, J.-Å. Gustafsson,
and C. Ohlsson: Estrogen receptor (ER)-reduces ER-regulated gene transcription,
supporting a “ying yang” relationship between ER and ER in mice. Mol. Endocrinol.
17, 203-208, 2003.
387.
G.J. Shim, L. Wang, S. Andersson, N. Nagy, L. Levente Kis, Q. Zhang, S. Mäkelä, M.
Warner and J.-Å. Gustafsson: Disruption of the estrogen receptor beta gene in mice
causes myeloproliferative disease resembling chronic myeloid leukemia with lymphoid
blast crisis. Proc. Natl. Acad. Sci. USA., 100, 6694-6699, 2003.
388.
C. M. Sadek, A. Jiménez, A. E. Damdimopoulos, T. Kieselbach, M. Nord, J.-Å.
Gustafsson, G. Spyrou, E.C. Davis, R. Oko, F. A. van der Hoorn, and A. MirandaVizuete: Characterization of human thioredoxin-like 2. J. Biol. Chem. 278, 13133-13142,
2003.
35
389.
E. Choleris, J.-Å. Gustafsson, K. S. Korach, L. J. Muglia, D. W. Pfaff, S. Ogawa: An
estrogen-dependent four-gene micronet regulating social recognition: A study with
oxytocin and estrogen receptor- and - knockout mice. Proc. Natl. Acad. Sci USA, 100,
6192-6197, 2003.
390.
H. Tazawa, W. Osman, Y. Shoji, E. Treuter, J.-Å. Gustafsson, and J. Zilliacus:
Regulation of subnuclear localization is associated with a mechanism for nuclear receptor
corepression by RIP140. Mol Cell Biol, 23, 4187-4198, 2003.
391.
B. Kauppi, C. Jakob, M. Färnegårdh, J. Yang, H. Ahola, M. Alarcon, K. Calles, O.
Engström, J. Harlan, S. Muchmore, A.-K. Ramqvist, S. Thorell, L. Öhman, J. Greer, J.Å. Gustafsson, J. Carlstedt-Duke, and M. Carlquist: RU-486 induces a transconformation that leads to active antagonism. J. Biol. Chem., 278, 22748-22754, 2003.
392.
Xu, Q. Pan-Hammarström, A. Försti, K. Hemminki, L. Hammarström, D. Labuda, J.-Å.
Gustafsson, and K. Dahlman-Wright: Human estrogen receptor  548 is not a common
variant in three distinct populations. Endocrinol. 144, 3541-3546, 2003.
393.
J.-Å. Gustafsson: What pharmacologists can learn from recent advances in estrogen
signaling. Trends Pharmacol. Sci., 2003.
394.
M. Otsuki, H. Gao, K. Dahlman-Wright, C. Ohlsson, N. Eguchi, Y. Urade and J.-Å.
Gustafsson: Specific regulation of lipocalin-type prostaglandin D synthase in mouse heart
by estrogen receptor . Mol. Endocrinol., 17, 1844-1855, 2003.
395.
J. Garey, A. Goodwillie, J. Frohlich, M. Morgan, J.-Å. Gustafsson, O. Smithies, K.S.
Korach, S. Ogawa, and D.W. Pfaff: Genetic contributions to generalized arousal of brain
and behavior. Proc. Natl. Acad. Sci USA, 100, 11019-11022, 2003.
396.
M. Färnegårdh, T. Bonn, S. Sun, J. Ljunggren, H. Ahola, A. Wilhelmsson, J.-Å.
Gustafsson, and M. Carlquist: The three-dimensional structure of the liver X receptor 
reveals a flexible ligand-binding pocket that can accommodate fundamentally different
ligands. J. Biol. Chem., 278, 38821-38828, 2003.
397.
A. Wärnmark, E. Treuter, A. P. H. Wright, and J.-Å. Gustafsson: Activation functions 1
and 2 of nuclear receptors: Molecular strategies for transcriptional activation. Mol.
Endocrinol., 17, 1901-1909, 2003.
398.
C Patrone, T. N. Cassel, K. Pettersson, Y.-S. Piao, G. Cheng, P. Ciana, A. Maggi, M.
Warner, J.-Å. Gustafsson, and M. Nord: Regulation of postnatal lung development and
homeostasis by estrogen receptor . Mol. Cell. Biol., 23, 8542-8552, 2003.
399.
S. Movérare, K. Venken, A.-L. Eriksson, N. Andersson, S. Skrtic, J. Wergedal, S.
Mohan, P. Salmon, R. Bouillon, J.-Å. Gustafsson, D. Vanderschueren, and C. Ohlsson:
Differential effects on bone of estrogen receptor  and androgen receptor activation in
orchidectomized adult male mice. Proc. Natl. Acad. Sci. USA, 100, 13573-13578, 2003.
400.
E. Mandelin, H. Lassus, M. Seppälä, A. Leminen, J.-Å. Gustafsson, G. Cheng, R.
Bützow, and Riitta Koistinen: Glycodelin in ovarian serous carcinoma: Association with
differentiation and survival. Cancer Res., 63, 6258-6264, 2003.
36
401.
K. T. Dalen, S. M. Ulven, K. Bamberg, J.-Å. Gustafsson, and H. I. Nebb: Expression of
the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X
receptor . J. Biol. Chem., 278, 48283-48291, 2003.
402.
S. Movérare, J. Dahllund, N. Andersson, U. Islander, H. Carlsten, J.-Å. Gustafsson, s.
Nilsson, and C. Ohlsson: Estren is a selective estrogen receptor modulator with
transcriptional activity. Mol. Pharmacol., 64, 1428-1433, 2003.
403.
J. S. Thomsen, S. Kietz, A. Strom, and J.-Å. Gustafsson: HES-1, a novel target gene for
the aryl hydrocarbon receptor. Mol. Pharmacol., 65, 165-171, 2004.
404.
M. Nilsson, S. Naessén, I. Dahlman, A. Lindén Hirschberg, J.-Å. Gustafsson and K.
Dahlman-Wright: Association of estrogen receptor  gene polymorphisms with bulimic
disease in women. Mol. Psychiatry, 9, 28-34, 2004.
405.
K. Steffensen and J.-Å. Gustafsson: Putative metabolic effects of the liver X receptor
(LXR). Diabetes, 53, S36-S42, 2004.
406.
A. Ström, J. Hartman, J.S. Foster, S. Kietz, J. Wimalasena, and J.-Å. Gustafsson:
Estrogen receptor  inhibits 17-estradiol-stimulated proliferation of the breast cancer
cell line T47D. Proc. Natl. Acad. Sci. USA, 101, 1566-1571, 2004.
407.
G.-J. Shim, L. Levente Kis, M. Warner, and J.-Å. Gustafsson. Autoimmune
glomerulonephritis with spontaneous formation of splenic germinal centers in mice
lacking the estrogen receptor alpha gene. Proc. Natl. Acad. Sci. USA, 101, 1720-1724,
2004.
408.
M. Hedengran Faulds, H. Olsen, L. A. Helguero, J.-Å. Gustafsson, and L.-A. Haldosén:
Estrogen receptor functional activity changes during differentiation of mammary
epithelial cells. Mol. Endocrinol., 18, 412-421, 2004.
409.
S. Sanyal, J. Matthews, D. Bouton, H.-J. Kim, H.-S. Choi, E. Treuter, and J.-Å.
Gustafsson: Deoxyribonucleic acid response element-dependent regulation of
transcription by orphan nuclear receptor estrogen receptor-related receptor . Mol.
Endocrinol. 18, 312-325, 2004.
410.
G. Cheng, Z. Weihua, M. Warner, and J.-Å. Gustafsson: Estrogen receptors ER and
ER in proliferation in the rodent mammary gland. Proc. Natl. Acad. Sci. USA, 101,
3739-3746, 2004.
411.
M. Tujague, J. S. Thomsen, K. Mizuki, C. M. Sadek, and J.-Å. Gustafsson: The focal
adhesion protein vinexin  regulates the phosphorylation and activity of estrogen receptor
. J. Biol. Chem., 279, 9255-9263, 2004.
412.
A. Chagin, M. K. Lindberg, N. Andersson, S. Moverare, J.-Å. Gustafsson, L. Sävendahl,
and C. Ohlsson: Estrogen receptor- inhibits skeletal growth and has the capacity to
mediate growth plate fusion in female mice. J. Bone Miner. Res., 19, 72-77, 2004.
413.
N. Heldring, M. Nilsson, B. Buehrer, E. Treuter, and J.-Å. Gustafsson: Identification of
tamoxifen-induced coregulator interaction surfaces within the ligand-binding domain of
estrogen receptors. Mol. Cell Biol., 24, 3445-3459, 2004.
37
414.
J. B. Seo, H. M. Moon, W. S. Kim, Y. S. Lee, H. W. Jeong, E. J. Yoo, J. Ham, H. Kang,
M.-G. Park, K. R. Steffensen, T. M. Stulnig, J.-Å. Gustafsson, S. D. Park, and J. B. Kim:
Activated liver X receptors stimulated adipcyte differentiation through induction of
peroxisome proliferator-activated receptor expression. Mol. Cell Biol., 24, 3430-3444,
2004.
415.
C. Palmieri, E. W.-F. Lam, J. Mansi, C. MacDonald, S. Shousha, P. Madden, Y. Omoto,
A. Sunters, M. Warner, J.-Å. Gustafsson and R.C. Coombes: The expression of ERcx in
human breast cancer and the relationship to endocrine therapy and survival. Clin. Cancer
Res., 10, 2421-2428, 2004.
416.
O. Imamov, A. Morani, G.-J. Shim, Y. Omoto, C. Thulin-Andersson, M. Warner, and J.Å. Gustafsson: Estrogen receptor regulates epithelial cellular differentiation in the
mouse ventral prostate. Proc. Natl. Acad. Sci. USA., 101, 9375-9380, 2004.
417.
M. Polanczyk, S. Yellayi, A. Zamora, S. Subramanian, M. Tovey, A. A. Vandenbark, H.
Offner, J. F. Zachary, P. D. Fillmore, E. P. Blankenhorn, J.-Å. Gustafsson, and C.
Teuscher: Estrogen receptor-1 (Esr1) and –2 (Esr22) regulate the severity of clinical
experimental allergic encephalomyelitis in male mice. Am. J. Pathology, 164, 19151923, 2004.
418.
A. Jiménez, Z. Wie, V. Y. Rawe, M. Pelto-Huikko, C. J. Flickinger, P. Sutovsky, J.-Å.
Gustafsson, R. Oko, and A. Miranda-Vizuete: Spermatocyte/spermatid-specific
thioredoxin-3, a novel golgi apparatus-associated thioredoxin, is a specific marker of
aberrant spermatogenesis. J. Biol. Chem., 279, 34971-34982, 2004.
419.
G.-J. Shim, M. Warner, H.-J. Kim, S. Andersson, L. Liu, J. Ekman, O. Imamov, M. E.
Jones, E. R. Simpson, and J.-Å. Gustafsson: Aromatase-deficient mice spontaneously
develop a lymphoproliferative autoimmune disease resembling Sjögren’s syndrome.
Proc. Natl. Acad. Sci. USA., 101, 12628-12633, 2004.
420.
A. E. Damdimopoulos, A. Miranda-Vizuete, E. Treuter, J.-Å. Gustafsson and G. Spyrou:
An alternative splicing variant of the selenoprotein thioredoxin reductase is a modulator
of estrogen signaling. J. Biol. Chem., 279, 28721-38729, 2004.
421.
M. Esslimani-Sahla, J. Simony-Lafontaine, A. Kramar, R. Lavaill, C. Mollevi, M.
Warner, J.-Å. Gustafsson, and H. Rochefort: Estrogen receptor  (ER) level but not its
ERcx variant helps to predict tamoxifen resistance in breast cancer. Clin. Cancer Res.,
10, 5769-5776, 2004.
422.
C. Förster, S. Kietz, K. Hultenby, M. Warner, and J.-Å. Gustafsson: Characterization of
the ER -/- mouse heart. Proc. Natl. Acad. Sci. USA., 101, 14234-14239, 2004.
423.
A. E. Kudwa, J.-Å. Gustafsson, and E. F. Rissman: Estrogen receptor  modulates
estradiol induction of progestin receptor immunoreactivity in male, but not in female,
mouse medial preoptic area. Endocrinol., 145, 4500-4506, 2004.
424.
H. Gronemeyer, J.-Å. Gustafsson, and V. Laudet: Principles for modulation of the
nuclear receptor superfamily. Nature Reviews Drug Discovery, 3, 950-964, 2004.
425.
J. C. Corton, U. Apte, S. P. Andersson, P. Limaye, L. Yoon, J. Latendresse, C. Dunn, J. I.
Everitt, K. A. Voss, C. Swanson, C. Kimbrough, J. S. Wong, S. S. Gill, R. A. S.
38
Chandraratna, M.-K. Kwak, T. W. Kensler, T. M. Stulnig, K. R. Steffensen, J.-Å.
Gustafsson and H. M. Mehendale: Mimetics of caloric restriction include agonists of
lipid-activated nuclear receptors. J. Biol. Chem., 44, 46204-46212, 2004.
426.
G. M. Leong, S. Moverare, J. Brce, N. Doyle, K. Sjögren, K. Dahlman-Wright, J.-Å.
Gustafsson, K.K.Y. Ho, C. Ohlsson and K.-C. Leung: Estrogen up-regulates hepatic
expression of suppressors of cytokine signaling-2 and –3 in vivo and in vitro.
Endocrinology, 145, 5525-5531, 2004.
427.
S. P. Anderson, C. Dunn, A. Laughter, L. Yoon, C. Swanson, T. M. Stulnig, K. R.
Steffensen, R. A. S. Chandraratna, J.-Å. Gustafsson, and J. C. Corton: Overlapping
transcriptional programs regulated by the nuclear receptors peroxisome proliferatoractivated receptor , retinoid X receptor, and liver X receptor in mouse liver. Mol.
Pharmacol., 66, 1440-1452, 2004.
428.
J. Harman, P. Müller, J. S. Foster, J. Wimalasena, J.-Å. Gustafsson, and A. Ström: HES1 inhibits 17-estradiol and heregulin-1-mediated upregulation of E2F-1. Oncogene, 23,
8826-8833, 2004.
429.
R. K. Vadlamudi, S. Balasenthil, R. R. Broaddus, J.-Å. Gustafsson and R. Kumar:
Deregulation of estrogen receptor coactivator proline-, glutamic acid-, and leucine-rich
protein-1/modulator of nongenomic activity of estrogen receptor in human endometrial
tumors. J. Clinic. Endocrinol. Metabol., 89, 6130-6138, 2004.
Participated in the supervision of the following Ph.D. and M.Sci students to the
presentation of their theses
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
Håkan Eriksson: Studies on the metabolism of steroid hormones in rat liver. Thesis,
1971.
Sven A. Gustafsson: Sexual differentation of corticosteroid metabolism in the rat. Thesis,
1974.
Åke Stenberg: Mechanisms of sexual differentiation of steroid metabolism in rat liver.
Thesis, 1974.
Magnus Ingelman-Sundberg: Hepatic metabolism of steroid sulphates with special
reference to cytochrome P-450-catalyzed reactions. Thesis, 1975.
Åke Pousette: Studies on the control of androgen responsiveness in rat. Thesis, 1976.
Örjan Wrange: Studies on the glucocorticoid receptor in rat liver and the estradiol
receptor in human breast cancer. Thesis, 1977.
Paul Skett: Hypophyseal control of hepatic steroid metabolism in the rat. Thesis, 1977.
Anders Berg: Studies on cytochrome P-450-dependent steroid hydroxylations in
mammalian and bacterial systems. Thesis, 1978.
Peter Ekman: Steroid receptors in the human prostate. Thesis, 1978.
Jan Carlstedt-Duke: Studies on two hepatic intracellular receptor proteins in the rat: The
glucocorticoid receptor and the 2,3,7,8-tetrachlorodibenzo-p-dioxin receptor. Thesis,
1979.
Björn Forsgren: Studies on a major protein in the ventral prostate of the rat that interacts
with metabolites of estramustine phosphate and related steroid-cytostatic complexes.
Thesis, 1979.
39
12.
13.
14.
15.
16.
17.
18.
19.
20
21.
22.
23.
24.
25.
26.
27.
28.
29.
30.
31.
32.
33.
34.
35.
36.
Erik Dahlberg: Studies on steroid hormone receptors in rat skeletal muscle. Thesis, 1980.
Zhao-Ying Yu: Studies of steroid hormone receptors in brain. Thesis, 1981.
Gunnar Norstedt: Regulations of prolactin and estrogen receptors in rat liver. Thesis,
1981.
Tiiu Hansson: Studies on hepatic steroid metabolism in rainbow trout, Salmo gairdneri.
Thesis, 1981.
Livia Alm: The effect of fermentation on nutrients in milk and some properties of
fermented liquid milk products. Thesis, 1982.
Rune Toftgård: Xylene, an inducer of hepatic cytochrome P-450 and xenobiotic
biotransformation in the rat. Thesis, 1982.
Joseph J. Rafter: Role of the intestinal microflora in the formation of sulphur-containing
conjugates of xenobiotics. Thesis, 1982.
Tapio Haaparanta: Isolation of subcellular fractions from the rat ventral prostate and
characterization of prostacic cytochrome P-450. Thesis, 1983.
Agneta Mode: Growth hormone - a regulator of the sexually differentiated steroid
metabolism in rat liver. Thesis, 1983.
Tönu Saartok: Steroid receptors as prediction of direct hormonal response in human and
rabbit skeletal muscle. Thesis, 1983.
Sam Okret: Immunochemical studies on glucocorticoid receptor structure and function.
Thesis, 1983.
Lorenz Poellinger: Characterization of the receptor for 2,3,7,8-tetrachlorodibenzo-pdioxin in rat liver. Thesis, 1985.
Catriona MacGeoch: Characterization and growth hormone regulation of sexually
differentiated cytochrome P-450 isozymes in rat liver. Thesis, 1986.
Johan Lund: Methyl sulfone metabolites of polychlorinated biphenyls: studies on the
mechanism of accumulation in lung. Thesis, 1986.
Ann-Charlotte Wikström: Production and use of monoclonal antibodies against the
glucocorticoid receptor. Thesis, 1986.
Agneta Blanck: The hypothalamo-pituitary-liver axis - a possible determinant of sex
differences in chemical hepatocarcinogenesis in the rat? Thesis, 1987.
Peter Söderkvist: Studies on regulation and enzymatic activity of drug-induced
cytochrome P-450 in rat ventral prostate. Thesis, 1987.
Mikael Gillner: Studies on the receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat.
Thesis, 1988.
Lennart Möller: 2-Nitrofluorence, in vivo metabolism and assessment of cancer risk of an
air pollutant. Thesis, 1988.
Mikael Brönnegård: Studies on the structure and function of the human and the rat
glucocorticoid receptor. Thesis, 1988.
Bolette Husman: Characterization of the somatogenic receptor in rat liver. Thesis, 1988.
Sam Törnquist: Uptake, metabolism and DNA-binding of the chemical carcinogens
benzo(a)-pyrene and 2-nitrofluorene in the rat lung. Thesis, 1989.
Marc Denis: The non-activated glucocorticoid receptor: structure and activation. Thesis,
1989.
Lars-Arne Haldosén: Characterization of the prolactin receptor in rat liver. Thesis, 1989.
Anders Berkenstam: Estrogen and progesterone receptors in human breast cancer cells:
studies on mechanisms for steroid dependent versus constitutive gene expression. Thesis,
1989.
40
37.
38.
39.
40.
41.
42.
43.
44.
45.
46.
47.
48.
49.
50.
51.
52.
53.
54.
55.
56.
57.
58.
59.
60.
61.
Eva Övervik: Formation and biological effects of cooked-food mutagens. Thesis, 1989.
Yu Dong: Transcriptional and post-transcriptional regulation of gene expression: Studies
on glucocorticoid receptor and alcohol dehydrogenase. Thesis, 1990.
Pia Lindeskog: Effects of diet on rat small intestinal cytochrome P-450 IA1. Thesis,
1990.
Scott Cuthill: The mechanism of action of the dioxin receptor. Thesis, 1990.
Gunnar Johansson: Effects of a shift from a mixed diet to a lactovegetarian diet on some
colon cancer associated characteristics. Thesis , 1990.
Karin Dahlman-Wright: DNA-binding by the glucocorticoid receptor: a structural and
functional analysis. Thesis, 1991.
Ann Lidbeck: Studies on the impact of Lactobacillus acidophilus on human microflora
and some cancer-related intestinal ecological variables. Thesis, 1991.
Carol Cairns: Mechanisms and role of DNA-binding in steroid hormone receptor action.
Thesis, 1993.
Gunnar Akner: Localization of glucocorticoid receptor (GR) and heat shock protein Mr
90,000 (Hsp90) in mammalian cells. Thesis, 1993.
Maria Strömstedt: Characterization of cytochrome P450 in rat ventral prostate and brain.
Thesis, 1993.
Olof Andersson: Structure and function of a Clara cell-specific, PCB-binding protein.
Thesis, 1993.
Per-Erik Strömstedt: Molecular analysis of glucocorticoid receptor-hormone interaction.
Thesis, 1993.
Anna Wilhelmsson: Mechanism of activation of the dioxin receptor. Thesis, 1993.
Wilhelm Cairns: A study of mechanisms involved in the control of glucocorticoid
receptor function. Thesis, 1993.
Anders Ström: Cloning, characterization and regulation of CYP2C genes expressed in rat
liver. Thesis, 1994.
Johanna Zilliacus: Structural determinants of DNA-binding specificity by the
glucocorticoid receptor. Thesis, 1994.
Petra Tollet: Growth hormone signal transduction and regulation of CYP2C12
expression in primary rat hepatocytes. Thesis, 1995.
Carol Soontjens: Ligands for nuclear receptors development and application of methods
for identification. Thesis, 1995.
Dezhong Liao: Hormonal regulation of sex differentiated liver carcinogenesis in the rat.
Thesis, 1996.
Stefan Westin: Regulation of cytochrome P4502C7: Effects of growth hormone and
vitamin A. Thesis, 1996.
Marika Kleman: Regulation of dioxin receptor function by procarcinogenic food-derived
heterocyclic amines and indolocarbazoles. Thesis, 1996.
Kaj Grandien: The estrogen receptor gene; promoter organization and expression. Thesis
1996.
Magnus Nord: Regulation and function of the Clara cell secretory protein. Thesis 1997.
Jacqueline McGuire: Mechanism of conditional regulation of the bHLH/PAS dioxin
receptor. Thesis, 1997.
Yang Yang: The in vivo metabolism of benzo[a]pyrene studied by chromatography in
combination with mass spectrometry. Thesis, 1997.
41
62.
63.
64.
65.
66.
67.
68.
69.
70.
71.
72.
73.
74.
75.
76.
77.
78.
Tova Almlöf: Gene regulation by the glucocorticoid receptor: Post-DNA binding
mechanisms of transcriptional activation. Thesis, 1997.
Heike Hellmold: Toxicological and endocrinological aspects of cytochrome P450 in
breast and lung. Thesis, 1998.
Thomas Meyer: Mechanism of conditional repression of human osteocalcin gene activity
by glucocorticoids. Thesis, 1998.
Tony Pircher: Regulation of STAT5 activity by growth hormone. Thesis, 1998.
Annika Wallberg: Chromatin remodeling complexes involved in gene activation by the
glucocorticoid receptor. Thesis, 1999.
Ulrika Lind: Functional analysis of ligand recognition by the glucocorticoid receptor.
Thesis, 2000.
Katarina Pettersson: Signal transduction via estrogen receptors (ERs) and estrogen
receptor-related receptors (ERRs). Thesis, 2000.
Thomas Barkhem: Molecular mechanisms of estrogen/antiestrogen action. M.Sci. thesis,
2000.
Johan Lidén: Repression of transcription factor NF-B by glucocorticods. A molecular
mechanism for their anti-inflammatory and immuno-modulatory effects. Thesis, 2000.
Eva Hedlund: Cytochrome P450 in the rat brain: Characterization and regulation. Thesis,
2000.
Tobias Cassel: Transcriptional regulation of differentiation markers in the distal lung
epithelium – A role for C/EBP factors. Thesis, 2001.
Sara Windahl: Functions of estrogen receptor  in the metabolism of rodent bone. Thesis,
2001.
Anette Wärnmark: Molecular mechanisms of gene activation by nuclear receptors and
their associated coregulators. Thesis, 2001.
Lotta Johansson: Studies on the atypical orphan receptor SHP. Thesis, 2001.
Zhang Weihua: Estrogen receptor  in the urogenital tract of both male and female.
Thesis, 2002.
Tomas Barkhem: Molecular Mechanisms of estrogen and antiestrogen action. Thesis,
2002.
Hanna Helander: Studies on growth hormone regulation of the CYP2C12 gene in rat
liver. Thesis, 2003.
79.
Christina Widén: Studies of glucocorticoid receptor interacting proteins. Licentiate
thesis, 2003.
80.
Anastasios E. Damdimopoulos: Identification and functional characterization of novel
thioredoxin systems. Thesis, 2003.
81.
Hanne Olsen: STAT5A expression and regulation in mammary epithelial cells. Thesis,
2004.
82.
Knut R. Steffensen: Putative functions of the liver X receptors in metabolic disorders.
Thesis, 2004.
83.
Malin Hedengran Faulds: Estrogen receptor signaling in mammary epithelial cells.
Thesis, 2004.
84.
Elin Holter: Modulation of nuclear receptor activity by a unique class of corepressors.
Thesis, 2004.
42
Postdocs and visiting scientists with Jan-Åke Gustafsson
Namn
From
To
1.
2.
3.
4.
5.
1970–1972
1971
1979
1979-1982
before 1981
2 years
1 year
1 year
3 years
2 years
6. Peter Hall
7. Jim Halpert
8. Edward Morgon
9. Rita Hannah
10. Gillian Howell
before 1981
1982-1984
1983–1987
1983
1984
1 year
2 years
4 years
1 year
1 year
11. Tony Wright
12. Constanze Bonifer
13. Ian Callard
14. Paolo Rossini
15. Janet Hapgood
1985–1990
1986–1987
1987
1985
1987
5 years
1 year
1 year
1 year
1.5 years
16. John Robertson
17. Grant Mason
18. Peter Zaphiropoulos
19. Hirotoshi Tanaka
20. Catherine Legraverend
870101
880101
880101
890616
890801
901231
920228
931215
910630
930731
21. Iain McEwan
22. Sarah Ben-Or
23. Chris Liddle
24. T Nemoto
25. Y Ohara Nemoto
891001
900101
900301
1989-1990
1989-1990
970131
901231
911031
2 years
2 years
26. Shin-Ichi Hayashi
27. Kevin Johnson
28. Katerine Gearing
29. Martin Göttlicher
30. Anke van Eekelen
1990-1991
1990
900401
910101
910201
2 years
1 year
930924
940221
920131
31. Eric First
32. Murray Whitelaw
33. Michèle Teboul
34. Roger Martin
35. Arvydas Kanopka
910401
910401
920115
920127
920215
940930
951231
941231
931231
921215
Cedric Shackleton
René-Jean Begue
Dominique Bression
Marek Snochowski
Rabinder Kurl
43
36. Adrian Wyss
37. Helen Osipova
38. Henry Barnes
39. Olivier Lahuna
40. Shigetaka Yoshida
920609
920801
920819
920909
930301
950630
940228
940831
960731
950228
41. Franck Delaunay
42. Anja Crickmore
43. Franziska Wiebel
44. Jaqueline Ford
930601
960117
930607
931101
931108
951015
980228
941101
951031
961031
45. Katrin Hecht
46. Carlos Bocos
47. Craig Rowlands
48. Eckardt Treuter
49. Greg Lamb
940112
940117
940117
940413
940708
951231
951231
951231
still
960630
50. Chris Corton
51. Dorothee Feltkamp
52. Siegfried Alberti
53. Hebe Guardiola-Diaz
54. Leandro Fernandez
940713
940801
940801
940819
940831
951031
990531
990228
960818
961013
55. George Kuiper
56. Alfin Vaz
57. Paula Lapinskas
58. Diane DePalo
59. Christine Sadek
941212
1995
950417
951002
951118
980901
6 months
960229
960229
040331
60. Stéphan Jalaguier
61. Martin Holtmann
62. Jörg Leers
63. Antonio Miranda
64. Markko Pelto-Huikko
960213
960311
960401
960613
960801
990630
970131
021031
still
980731
65. Francis Simon
66. Ralf Meyer
67. Jane Sohn-Thomsen
68. Sari Mäkelä
69. Kenichi Mikitani
“
“
960916
961001
961201
1997
970121
000515
970630
970801
040630
still
990531
still
70. Michel Tujague
71. Giulia Friso
72. José Pedrajas-Cabrero
970414
970513
970609
still
980131
990630
44
73. Francoise Caira
74. Moraima Zelada
970701
970915
990610
001231
75. Jeanette Webster
76. Gordon Jamieson
77. Gertrud Schuster
78. Gary Faulds
79. Elwood Jensen
980301
980415
980602
980608
980122
010430
990228
040630
000430
010331
80. Naoya Arai
81. Adrian Allan
82. Anni Wärri
83. Kazuhito Mizuki
84. Domingo N-Bosch
980615
980901
980901
981216
990118
990930
000831
990831
011031
000430
85. Jerzy Adamski
86. Shigehira Saji
87. Guojun Cheng
88. Zhao Bian
89. Ling Wang
990301
990414
990914
991001
991020
000229
010131
still
020731
030228
90. Cesare Patrone
91. Silke Kietz
92. Carola Förster
93. Michio Otsuki
94. Hideki Sakaguchi
000405
000602
000703
000801
000808
010731
030531
030430
030920
021231
95. Chunyan Zhao
96. Thomas Stulnig
97. Alberto Jiménez Garcia
98. Jian Lu
99. Gil-jin Shim
010101
010302
010702
010816
010901
still
020331
still
020815
still
100.Andrew Sakko
101. Kirsten Robertson
102. Qing Hong Zhang
103. Jason Matthews
104. Didier Bouton
010903
010915
011001
011010
011030
021231
still
020630
still
041031
105. Sabyasachi Sanyal
106. Yungshang Piao
107. Yoko Omoto
108. Yutaka Shoji
109. Luisa Helguero
110. Jinghong Wan
020520
020604
020729
020906
030203
030314
still
040531
still
040817
still
still
45
Invited lecturer at the following international symposia:
1.
3rd Int. Congress of Hormonal Steroids, Hamburg, West Germany, September,
1970: "The role of the intestinal microflora in steroid metabolism".
2.
The Royal Society Meeting, London, UK, 1972: "Steroids in meconium and faeces
from newborn infants".
3.
The Journal of Steroid Biochemistry Meeting, Paris, France, April 1974: "Sexual
Differentiation of Hepatic Steroid Metabolism in the Rat".
4.
Int. Congress of Hormonal Steroids, Mexico, September 1974: "Neonatal
androgenic programming of hepatic steroid metabolism in rats".
5.
III Bile Acid Meeting on Advances in Bile Acid Research, Freiburg i. Br., West
Germany, June, 1974: "Causes of differences between germfree and conventional
rats in liver microsomal metabolism of steroids".
6.
Meeting of the Journal of Steroid Biochemistry, Paris, France, 1976: "Programming
and differentiation of rat liver enzymes".
7.
Int. Meeting on Progesterone Receptors in Normal and Neoplastic Tissues,
Montreal, Canada, 1976: "Progestin receptor in endometrial carcinoma".
8.
568th Meeting of the Biochemical Society in Aberdeen on Steroid Binding and
Oligomeric Proteins, Aberdeen, Scotland, 1976: "Glucocorticoid-receptor
interactions in rat liver".
9.
III Int. Symposium on Microsomes and Drug Oxidations, Berlin, West Germany,
1976: "Studies on a cytochrome P-450-dependent hydroxylase system active on
steroids in Bacillus megaterium".
10.
Fogarty Conference on Neonatal Hepatitis and Biliary Atresia, Bethesda, USA,
March 1977: "Steroid metabolism in the fetal and perinatal period".
11.
Int. Symposium on Hormones and Brain Development, Berlin, German Democratic
Republic, 1978: "Central control of a cytochrome P-450-dependent steroid
hydroxylase in rat liver".
12.
Fogarty Conference on Hormones and Cancer, Bethesda, USA, March 1978:
"Estradiol receptor analysis in human breast cancer tissue by isoelectric focusing in
polyacrylamide gel".
13.
Scientific Conf. on Cytochrome P-450: Structural and Functional Aspects,
Eberswalde, German Democratic Republic, July 1978: "Pituitary control of hepatic
steroid metabolism".
14.
Nobel Symposium on Central Regulation of the Endocrine System, Stockholm,
Sweden, 1979: "Sexual differentiating actions of steroids on the hypothalamopituitary-liver axis".
46
15.
IV Int. Symposium on Microsomes, Drug Oxidations and Chemical
Carcinogenesis, Ann Arbor, USA, 1979: "Characterization of a steroidhydroxylating cytochrome P-450 of bacterial origin".
16.
Workshop of the Society of Urologic Oncology and Endocrinology: Steroid
Receptors, Metabolism and Prostatic Cancer, Amsterdam, The Netherlands, April
1979: "On the presence of a major protein, prostatic secretion protein or
estramustine-binding protein, in the rat ventral prostate and in the human prostate".
17.
Int. Symposium on the Biochemistry, Biophysics and Regulation of Cytochrome P450, Stockholm, Sweden, 1980: "The hypothalamo-pituitary-liver axis: a novel
regulatory system in the control of cytochrome P-450".
18.
Int. Meeting on Endocrines and the Environment, Morristown, USA 1980: "Role of
the hypothalamo-pituitary-liver axis in sex differences in susceptibility of the liver
to toxic agents".
19.
Int. Meeting on Steroid Hormone Regulation of the Brain, Stockholm, October
1980: "Studies on the glucocorticoid receptor".
20.
Int. Workshop on Nutrition and Cancer, Cambridge, UK, July 1980: "The effect of
intestinal microflora on the enterophepatic circulation of mercapturic acid pathway
metabolites".
21.
II Int. Meeting on Gene Regulation by Steroid Hormones, Detroit, USA, September
1981: "Functional analysis of the glucocorticoid receptor by limited proteolysis".
22.
Int. Meeting on the Prostatic Cell: Structure and Function, Buffalo, USA, 1981:
"Induction of cytochrome P-450 and metabolic activation of mutagens in the rat
ventral prostate".
23.
Int. Symposium on Nutrition and the Intestinal Flora, Saltsjöbaden, Sweden, June
1981: "Metabolism of steroid hormones in germfree and conventional rats".
24.
Int. Symposium on Corticosteroid Treatment in Allergic Airway Diseases,
Copenhagen, Denmark, October 1981: "Glucocorticoid-binding proteins in rat
liver".
25.
V Int. Symposium on Microsomes and Drug Oxidations, Tokyo, Japan, July 1981:
"Central control of sexual differentiation of hepatic steroid metabolism in the rat".
26.
Int. Symposium on Development Pharmacology, Toronto, October 1982: "Growth
hormone: a regulator of the sexually differentiated steroid metabolism in rat liver".
27.
Int. Symposium on Medroxyprogesterone Acetate, Geneva, Switzerland, February
1982: "The mechanism of hormone action".
28.
First American-Swedish Workshop on Individual Susceptibility to Genotoxic
Agents in the Human Population, Research Triangle Park, USA, May 1982: "On
the possible significance of TCDD receptor based assays in attempts to estimate
environmental health hazards".
47
29.
Serono Symposium No 51 on The Endocrines and the Liver, Rome, Italy, 1982:
"Studies on the hypothalamo-pituitary-liver axis: a novel concept in regulation of
steroid and drug metabolism".
30.
First European Congress on Cell Biology, Paris, France, July 1982: "Isoelectric
focusing and enzyme-linked immunosorbent assay of steroid hormone receptors".
31.
Meeting of the Journal of Steroid Biochemistry, Paris, France, 1982: "Regulation of
sexually dimorphic hepatic steroid metabolism by the somatostatin-growth
hormone axis".
32.
Int. Meeting on Extrahepatic Drug Metabolism and Chemical Carcinogenesis,
Stockholm, Sweden, May 1983: "Soluble receptor proteins in control of gene
expression".
33.
Int. Symposium on Hormones and Cancer, Buenos Aires, Argentina, May 1983:
"On the use of antibodies in studies on glucocorticoid receptor structure".
34.
II Int. Congress on Hormones and Cancer, Monte Carlo, Monaco, September 1983:
"Studies of steroid hormone receptors in brain".
35.
Nobel Symposium on Steroid Hormone Receptors: Structure and Function,
Karlskoga, Sweden, September 1983: "On the use of poly- and monoclonal
antibodies in studies on the structure and function of the glucocorticoid receptor".
36.
Int. Symposium on the Regulation of Androgen Action, Montreal, Canada, June
1984: "Characterization of prostatic cytochrome P-450".
37.
IX Int. Congress of Pharmacology, London, UK: August 1984: "Recent studies on
the mechanism of action of glucocorticoids".
38.
Meeting of the International Union of Physiological Sciences, Jerusalem, Israel,
August 1984: "New insights into the mechanism of glucocorticoid hormone
action".
39.
Int. Symposium on Diet and Prevention of Coronary Heart Disease and Cancer,
Stockholm, Sweden, October 1984: "Metabolism of xenobiotic compounds".
40.
Argenteuil Symposium: The Role of Receptors in Biology, Brussels, Belgium,
October 1984: "Purification and DNA binding of mammalian glucocorticoid
receptor".
41.
Int. Meeting on P-450 Genes and their Regulation, Airlie, USA, April 1985:
"Growth hormone regulation of sex-specific hepatic cytochrome P-450 isozymes".
42.
GREMI Symposium: Glucocorticoides aujourd'hui, Paris, France, May 1985:
"Glucocorticoid receptor-DNA interactions".
43.
IX Nobel Conference on Thioredoxin and Glutaredoxin Systems - Structure and
Function, Lidingö, Sweden, May 1985: "Regulation, structure and function of the
glucocorticoid receptor".
48
44.
7th Int. Symposium of the Journal of Steroid Biochemistry on Recent Advances in
Steroid Biochemistry, Seefeld, Austria, June 1985: "Structure and tissue
localization of the glucocorticoid receptor".
45.
6th Int. Symposium on the Biochemistry of Exercise, Copenhagen, June 1985:
"Characterization and regulation of growth hormone receptor in rat liver".
46.
3rd ECP Symposium on Diet and Human Carcinogenesis, Aarhus, Denmark, June
1985: "Naturally occurring carcinogens protective factors".
47.
IV Int. Conf. on Environmental Mutagens; Satellite Meeting Genetic Toxicology of
the Diet, Copenhagen, June 1985: "Mutagens formed in the gastro-intestinal tract".
48.
SEPCR Congress on Clinical Applications of Corticosteroids, The Hague, The
Netherlands, June 1985: "Mechanisms of action of glucocorticosteroids at the
subcellular level".
49.
1985 Gordon Conference on Hormone Action, Kimball Union, New Hampshire,
USA, August 1985: "Glucocorticoid regulated genes".
50.
5th Int. Conference on Biochemistry, Biophysics and Induction of Cytochrome P450, Budapest, August 1985: "Biochemical and biophysical characterization of the
TCDD receptor - a comparison to steroid hormone receptor".
51.
3rd Meadow Brook Conference on the Molecular Mechanism of Steroid Hormone
Action, Rochester, USA, September 1985: "Mechanism of sex differentiation of rat
liver".
52.
Int. Symposium on Monoclonal Antibodies: Basic Principles, Experimental and
Clinical Applications in Endocrinology, Florence, Italy, October 1985:
"Monoclonal antibodies to glucocorticoid receptors".
53.
First Int. Congress on Cancer and Hormones: Endocrinology and Malignancy:
Basic and Clinical Issues, Rome, Italy, April 1986: "Regulation of glucocorticoid
receptor".
54.
Second Int. Symposium in Hematology and Oncology organized by The
Hematology Collaborating Group at the Karolinska Hospital under the auspices of
the Karolinska Institute in honour of Prof. J.G. Waldenström: Immunoglobulins
and Growth Factors in Hematology and Oncology, Stockholm, May 1986:
"Glucocorticoid mechanism of action: monoclonal antibodies as experimental
tools".
55.
NATO Advanced Research Workshop on Plant Hormone Receptors, Bonn, August
1986: "Mechanism of action of glucocorticoid hormones".
56.
Satellite Symposium of 7th International Congress on Hormonal Steroids: AntiSteroids, Marbella, Spain, September 1986: "Gene expression and hormone
receptors".
57.
59th Annual Meeting of the Japanese Biochemical Society, Osaka, September
1986: "Regulation and expression of cytochrome P-450 in liver and brain".
49
58.
The Molecular Biology of Drug Metabolizing Enzymes, London, December 1986:
"Hormonal control of sex specific cytochrome P-450 isozymes in rat liver".
59.
UCLA Symposia on Molecular and Cellular Biology: Steroid Hormone Action,
Park City, Utah, USA, January 1987: "Structure, function and localization of the
glucocorticoid receptor".
60.
2nd Internation Workshop on P450 Gene Regulation, Airlie, Virgina, USA, April
1987: "Cloning and regulation of cytochrome P45015ß and P45016a in rat liver".
61.
7th International Symposium on Microsomes and Drug Oxidations, Adelaide,
Australia, August 1987: "Role of endocrine factors in the regulation of cytochrome
P-450 expression".
62.
625th meeting of the Biochemistry Society on "Molecular Biology of Hormone
Action" Dublin, Irland, September 1987: "Mechanism of Action of Glucocorticoid
Hormones".
63.
8th European Winter Conference on Brain Research, Tignes/Val d'Isere, France,
March 1988: "On the Expression and Regulation of the Glucocorticoid Receptor".
64.
"Glucocorticoids - from cloning to clinic", Edinburgh, England, May 1988.
65.
8th International congress of Endocrinology, Kyoto, Japan, July 1988: "The dioxin
and glucocorticoid receptors: two similar gene regulatory proteins".
66.
6th Biophysics-Biochemistry of cytochrome P-450 congress, Vienna, Austria, July
1988: "Glucocorticoid & dioxin receptors - a comparison".
67.
Fourth International Symposium on Cellular Endocrinology, Lake Placid, USA,
August 1988: "Structure, function and regulation of the glucocorticoid receptor".
68.
NATO Advanced Research Workshop on "Molecular Mechanisms and
Consequences of Activation of Hormone and Growth Factor Receptors, Nafplion,
Greece, September 1988: "Glucocorticoid receptor".
69.
Molecular biology in drug design and in drug production, Uppsala, Sweden,
December 1988: "Role of ligand binding in glucocorticoid receptor function".
70.
9th International symposium of the Journal of Steroid Biochemistry, Las Palmas,
Canary Islands, Spain, May 1989: "Expression and structure of the Glucocorticoid
Receptor".
71.
Biochemical Society meeting, Host Colloquium on "Development of MixedFunction Oxidases", Surrey, UK, July 1989: "The cytochromes P-450 of brain and
their role in the metabolism of neurosteroids".
72.
Molecular Biology and Pathophysiology of Hormone Regulation and Actions,
Heidelberg, West Germany, July 1989: "Expression, structure and regulation of the
glucocorticoid receptor".
73.
FASEB Summer Research Conference: "Nutrients, Gene Expression, and Cancer",
Copper Mountain, Colorado, USA, July 1989: "Mechanisms of GH effects on liver
cytochrome P-450 isozymes".
50
74.
NATO Advanced Study Institute on "Molecular aspects of monooxygenases and
bioactivation of toxic compounds", Cesme, Izmir, Turkey, September 1989:
"Hormonal Regulation of P-450 Gene Expression" and "Xenobiotic Regulation of
P-450 Gene Expression".
75.
Fourth International Symposium in Hematology and Oncology, Stockholm,
Sweden, September 1989: "Nutrition and cancer".
76.
Steroid Receptors, Transcription Factors, and Gene Expression, San Diego, USA,
February 1990: "Mechanisms of steroid nonresponsiveness in mutant cell lines".
77.
NORDTOX-90, 1st Nordic Conference of Toxicology and 8th Annual Meeting of
Nordic Environmental Mutagen Society, Beito, Norway, March 1990: "Mechanism
of dioxin regulation of cytochrome P-450".
78.
Berzelius symposium, The Swedish Society of Medicine, Stockholm, Sweden,
March 1990: "Ligand-steroid receptor interactions".
79.
Scandinavian Physiological Society Meeting, Lund, Sweden, May 1990: "On the
use of molecular biology in endocrinology".
80.
VIIIth International Symposium Microsomes and Drug Oxidations, Karolinska
Institutet, Stockholm, Sweden, June 1990: "Receptor-mediated regulation of gene
expression".
81.
Eighth international conference on Methods in protein sequence analysis, Kiruna,
Sweden, July 1990: "Steroid receptor-DNA interactions".
82.
NATO ASI on Biological Signal Transduction, Spetsai, Greece, August 1990:
"Steroid Receptors I: General background, steroid structure and metabolism,
purification and cloning of steroid receptors, members of the steroid receptor
supergene family". "Steroid receptors II: Regulation of expression of the
glucocorticoid receptor (GR) gene. Bacterial expression of the DNA binding
domain DBDr) of GR. The three-dimensional structure of the DBDr-DNA
complex".
83.
First Düsseldorf Symposium on Immunotoxicology: Molecular Mechanisms of
Dioxin Action on Cell Growth and Differentation, Düsseldorf, Germany, October,
1990: "TCDD receptor: physicochemical characteristics and its significance for
toxicological effects".
84.
Hepatic Metabolism and Disposition of Endo- and Xenobiotics, Freiburg,
Germany, October, 1990: "Comparative Studies of the Glucocorticoid and TCDDReceptors".
85.
Biological Basis For Risk Assessment of Dioxins & Related Compounds, Banbury,
USA, October, 1990: "Molecular biology and physiology of TCDD receptor - DNA
interactions".
86.
Symposium in honour of Professor Minor J. Coon, Ann Arbor, USA, November,
1990: "The glucocorticoid receptor: Structure, function and regulation".
51
87.
Xenobiotics and Cancer: Implications for chemical carcinogenesis and cancer
chemotherapy, Tokyo, Japan, November, 1990: "The molecular biology of the
glucocorticoid and dioxin receptors".
88.
First International symposium on hormonal carcinogenesis, Cancun, Mexico,
March, 1991: "Sexual dimorphism of hepatic steroid hormone metabolism and its
significance for chemical hepatocarcinogenesis".
89.
Cytochrome P450: Advances and prospects, Atlanta, USA, April, 1991:
"Regulation of rodent cytochrome P-450 gene expression by steroid hormones".
90.
10th International Symposium of the Journal of Steroid Biochemistry and
Molecular Biology, Paris, France, May, 1991: "Glucocorticoid receptor: structural
and functional studies".
91.
7th International Conference "Biochemistry & Biophysics of Cytochrome P-450;
Structure & Function, Biotechnological & Ecological Aspects", Moscow, U.S.S.R,
August 1991: "Molecular mechanisms in regulation of cytochrome P-450 gene
expression".
92.
1991 Gordon Conference on Hormone Action, New Hampshire, USA, August,
1991: "Structure and Function of the Three Domains of the Glucocorticoid
Receptor".
93.
Arolla Workshop 1991 "From Receptor to Gene", Arolla, Switzerland, August,
1991: "Structure and Function of the Three Domains of the Glucocorticoid
Receptor".
94.
International Symposium on A Molecular View of Steroid Biosynthesis and
Metabolism, Jerusalem, Israel, October 1991: "Hepatic steroid metabolism is
controlled by the sexually dimorphic pattern of growth hormone secretion in both
normal and dwarf rats".
95.
European Research Conference on "Mechanism in Toxicity", Klingenthal, Alsace,
France, November 1991: "TCDD receptor(s) and their relevance for
carcinogenesis".
96.
Keystone Symposia on Molecular and Cellular Biology, Steroid/thyroid receptor
gene super family, Tamarron, Colorado, USA, February, 1992: "Structural and
functional studies on the glucocorticoid receptor".
97.
Centre de Recherche du Chul, Québec, Canada, May, 1992: "On the structure and
function of the glucocorticoid receptor".
98.
Wallenberg Symposium, The Metabolic syndrome, Gothenburg, Sweden, May,
1992: "Mechanism of action of steroid hormones".
99.
NOMBA, Progress in Molecular Biology, Helsinki, Finland, May, 1992:
"Molecular biology of the glucocorticoid receptor".
100.
Endocrine Society Meeting, San Antonio, Texas, USA, June, 1992:
"Overexpression in Bacteria, Yeast and Eukaryotic Cells of Steroid Receptors and
Steroid Receptor Domains".
52
101.
9th International Symposium on Microsomes and Drug Oxidations, Jerusalem,
Israel, July, 1992: "Mechanisms of regulation of expression of hepatic cytochrome
P-450".
102.
5th International congress on Cell Biology, Madrid, Spain, July, 1992: "Functional
analysis of the three domains of the glucocorticoid receptor".
103.
NATO/FEBS on New Developments in Lipid-Protein Interactions and Receptor
Function, Spetsai, Greece, August, 1992: "Determinants for DNA binding site
recognition by the glucocorticoid receptor". "Fatty acids activate a chimera of the
clofibric acid-activated receptor and the glucocorticoid receptor".
104.
11th International Conference on Comparative Physiology, The Differences
between the sexes, Crans-sur-Sierre, Switzerland, September, 1992: "Why are there
male and female livers and kidneys?".
105.
The University of Oslo, Jahreföreläsning, Oslo, Norge, September, 1992: "The
functional architecture of the glucocorticoid receptor".
106.
Keith Harris lecture, Australian Endocrine Society, Adelaide, Australia, October,
1992: "The molecular biology of the glucocorticoid receptor".
107.
Invited lecturer at Collége de France, Paris, France, October, 1992: "Functional
architecture of the glucocorticoid receptor".
108.
Invited lecturer at University of California, Berkeley, USA, October, 1992:
"Functional architecture of the glucocorticoid receptor".
109.
The Karolinska-Minnesota Frontiers of Medicine Symposium, Minnesota, USA,
October, USA, 1992: "Functional architecture of the glucocorticoid receptor".
110.
American association for the study of liver diseases, Chicago, Illinois, USA,
November, 1992: "Hormonal regulation of Cytochromes P-450".
111.
The 23rd International Symposium of the Princess Takamatsu Cancer Research
Fund, Tokyo, Japan, November, 1992: "Induction of cytochrome P450 1A
isozymes by heterocyclic amines and other food derived compounds".
112.
Functions and structures of genes and proteins, Mariehamn, Åland, November,
1992: "Structure and function of the glucocorticoid receptor".
113.
Perspectives in Nutrition Research Towards Year 2000, Oslo, Norway, December
1992: "Molecular Nutrition: Regulation of Gene Expression by Fatty Acids".
114.
Receptor Mediated Biological Processes: Implication for Evaluating Carcinogens,
Austin, Texas, December 1992.
115.
Symposium on Fat and Gene Expression, New Orleans, U.S.A., March, 1993:
"Fatty acid activation of the peroxisome proliferator activated receptor (PPAR), a
member of the nuclear receptor supergene family".
116.
Biochemistry, Endocrinology and Pharmacology of Nuclear Receptors, Marburg,
Germany, May, 1993: "Fatty acid activation of PPAR".
53
117.
11th International Symposium of The Journal of Steroid Biochemistry and
Molecular Biology "Recent advances in steroid biochemistry and molecular
biology", Seefeld, Austria, May/June, 1993: "Structure and function of the
glucocorticoid receptor".
118.
The Karolinska Institute and the Summer University of Southern Stockholm,
"Understanding Signal Transduction", Stockholm, Sweden, June, 1993:
"Steroid/thyroid hormone receptors".
119.
18th International Congress of Chemotherapy, "Principles of endocrine treatment of
cancer - basic aspects and clinical regimens", Stockholm, Sweden, June, 1993:
"Basic aspects on steroid hormone actions".
120.
International Symposium on Antioxidants and Disease Prevention, Biochemical,
Nutritional, and Pharmacological Aspects, Stockholm, Sweden June/July, 1993:
"Control of Gene Expression by Fatty Acids and Retinoids".
121.
22nd Meeting of the Federation of European Biochemical Societies, Stockholm,
Sweden, July, 1993: "The functional architecture of the glucocorticoid receptor".
122.
Second Asia-Pacific Symposium on Environmental and Occupational Health Toxicological Studies, Kobe, Japan, July, 1993: "Mechanisms of Induction of
Cytochrome P450 by Environmental Agentsparticipation of Ligand Activated
Transcription Factors from Two Different Gene Families".
123.
5th International CBT Symposium, "Intracellular hormone receptors and liganddependent transcriptional regulation", Stockholm, Sweden, September, 1993:
"Activation of PPAR by fatty acids".
124.
Instituto Juan March de Estudios e investigaciones, Centre for International
Meetings on Biology. Workshop on Neuroendocrinology of Growth. Madrid,
Spain, October, 1993: "Mechanisms of sex differentiation and growth hormone
regulation of hepatic P450 genes in the rat".
125.
8th International Conference on Cytochrome P450, Lisbon, Portugal, October,
1993: "Mechansims of sex differentiation and growth hormone regulation of
hepatic P450 genes in the rat".
126.
4th International Thyroid Symposium on "Genetic defects of thyroid and steroid
hormons receptors: molecular basis and clinical expression", Ulm, Germany,
November, 1993: "Thyroid and steroid hormone receptor family".
127.
Biochemical Society Meeting 649, London, U.K., December, 1993: "Receptormediated regulation of drug metabolising enzymes".
128.
Norsk Biokjemisk Selskaps 30 årsjubileumsmöte, January, 1994: "Novel aspects on
ligand activated transcription factors".
129.
Keystone Symposia on Molecular and Cellular Biology, Taos, New Mexico,
February, 1994: "The dioxin receptor - another ligand activated transcription
factor".
54
130.
Symposium on Eukaryotic Gene Expression and Regulating Signals, New York,
April, 1994: "Functional architecture of the glucocorticoid receptor and
characteristics of some novel members of the steroid/thyroid hormone receptor
super family".
131.
The Lundberg Symposium, Gothenburg, May, 1994: "Nuclear receptors - an
expanding super gene family".
132.
Nordic Meeting on Biochemical and Medical Aspects of Lipid Metabolism in
Peroxisomes and Mitochondria, Huddinge, Sweden, May, 1994: "Activation of the
PPAR".
133.
The First International Conference on Steroids and Bone, Florence, Italy, May,
1994: "The functional architecture of the glucocorticoid receptor".
134.
United European Gastroenterology week June 25-29, 1994, Oslo, Norway: "Fatty
acid control of gene expression via a member of the nuclear receptor supergene
family (PPAR)".
135.
XIIth International Congress of Pharmacology, Montréal, Québec, Canada, July,
1994: "Fatty acid activation of PPAR".
136.
10th International Symposium on Microsomes & Drug Oxidations, Toronto,
Canada, July, 1994: "Functional analysis of flanking sequences of sex-specific P450 genes expressed in rat liver".
137.
Second International Symposium on Hormonal Carcinogenesis, Novum,
Stockholm, July, 1994: "Novel Aspects on Ligand Activated Transcription Factors
in Control of Cytochrome P-450".
138.
NATO Advanced Study Institute on Molecular Mechansims of Transcellular
Signaling: "From the Membrane to the Gene", Spetsai, Greece, August, 1994:
"Recent developments in the field of the nuclear receptor supergene family" and
"The dioxin receptor - another ligand activated transcription factor".
139.
University of Wisconsin-Madison: "Steroid Receptor Superfamily Symposium",
Madison, USA, September, 1994: "Functional analysis of the glucocorticoid
receptor".
140.
IX International Congress on Hormonal Steroids. Dallas, Texas, USA, September,
1994: "Activation of the PPAR".
141.
Health Research in Quebec and the world: today and tomorrow: Montréal, Canada,
October, 1994: "University-Industry Partnership in Sweden".
142.
Worcester Foundation for Experimental Biology, Gregory Pincus Lecture,
Shrewsbury, MA, USA, November, 1994: ”Functional organization of the
glucocorticoid receptor”.
143.
Symposium on "Bridging Basic Science and Liver Disease". Boston, USA,
November, 1994: "Mechanisms of growth hormone regulation of sexually
differentiated gene expression in the liver".
55
144.
Receptor Mediated Mechanisms in Carcinogenesis, Lyon, France, November,
1994: "Nuclear Receptors and Chemical Carcinogenesis".
145.
Keystone Symposia conference on ”Molecular Toxicology”, Keystone, USA,
January, 1995: ”Functional architecture of the dioxin receptor/arnt heterodi-mer”.
146.
An AACR Special Conference in Cancer Research: ”Mechanism of action of
retinoids, vitamin D, and steroid hormones”, Whistler, British Columbia, Canada,
January, 1995: ”Mechanisms of activation and action of PPAR (Peroxisome
Proliferator Activated Receptor).
147.
Sterling lecture, University of Pennsylvania, Philadelphia, USA, March, 1995:
Mechanism of action of the glucocorticoid receptor and of the peroxisome
proliferatoractivated receptor (PPAR).
148.
EMBO Workshop; Structure and Function of Steroid and Nuclear Receptors,
Alghero, Sardinia, Italy, April, 1995: ”Transcriptional activation by the
glucocorticoid receptor: Role of the 1 domain”.
149.
Pharmacology & Toxicology 50th Anniversary Symposium, Perspectives in the
development and safety of new medicines: Biological diversity and structure
specificity, Copenhagen, Denmark, May, 1995: ”Mechanisms of Regulation of
Drug Metabolizing Enzymes”.
150.
12th International Symposium of the Journal of Steroid Biochemistry and
Molecular Biology. ”Recent Advances in Steroid Biochemistry and Molecular
Biology”, Berlin, Germany, May, 1995: ”Functional Analysis of the glucocorticoid
receptor”.
151.
The Aspen Institute: Peroxisomes: Biology and Role in Toxicology and Disease,
Aspen, USA, June/July 1995: ”Fatty acid signalling of peroxisome proliferatoractivated receptor”.
152.
VII International Congress of Toxicology, Seattle, USA, July, 1995: ”Receptormediated toxicity”.
153.
Gordon Research Conference on Hormone Action, New Hampshire, USA,
July/August, 1995: ”Functional organization of the dioxin receptor-Arnt complex”.
154.
The Rank Prize Funds, Mini-Symposium on Nutrients as Regulators (Nutrient
Sensing), Grasmere, England, September, 1995: “Regulation of gene expression by
fatty acids”.
155.
7th International CBT Symposium: Nuclear Orphan Receptors: Novel Regulators
in Physiology and Pathology, NOVUM, Sweden, September, 1995: ”Mechanism of
signal transduction of PPAR”.
156.
International Symposium on ”DHEA Transformation into Androgens and
Estrogens in Target Tissues: Intracrinology”, Québec, Canada, September, 1995:
”Activation of peroxisome proliferator activated receptor (PPAR)”.
157.
The European Respiratory Society Annual Congress, Barcelona, Spain, September,
1995: ”Glucocorticoid receptor and transcription factor interactions”.
56
158.
International Symposium on Control Mechanisms of Carcinogenesis, Mainz,
Germany, September, 1995: ”Ligand activated transcription factors”.
159.
The British Biochemical Society Meeting No. 657, Aberdeen, U.K., December,
1995: ”Control of gene expression by fatty acids: Role of the peroxisome
proliferator activated receptor (PPAR)”.
160.
From Invention to Business in Biotechnology, Helsinki, Finland, January, 1996:
”Future scenarios for Biocenters”.
161.
Keystone Symposia on Molecular and Cellular Biology, Steroid/Thyroid/Retinoic
Acid Gene Family, Lake Tahoe, California, March, 1996: “Cloning of a novel
estrogen receptor (ER)”.
162.
2nd Oulu Symposium on Molecular Approaches to Reproductive Health, Oulu,
Finland, May, 1996: “Orphan receptors and the search for endogenous ligands”.
163.
International Society for Endocrinology, San Francisco, USA, June, 1996:
”Negative cross-talk between the glucocorticoid receptor and other signal
transduction pathways”.
164.
NATO/FEBS Advanced Study Institute, International Summer School on
Molecular Mechanisms of Signaling and Targeting, Spetsai, Greece, August, 1996:
”Orphan nuclear receptors - an exciting development of the steroid/thyroid
hormone receptor field” and ”Growth hormone as determinant of hepatic sexual
dimorphism”.
165.
Estrogen and the Blood Vessel Wall Symposium, Seattle, Washington, USA,
September, 1996: ”Cloning, Expression and Function of a Novel Estrogen
Receptor”.
166.
KBF-Symposium Molecuar Targets for Drug Development, Braunschweig,
Germany, September, 1996: ”Steroid receptors as molecular targets for drug
development”.
167.
SPBBM, Colloque GERMÉ, PPARs, nutriments and xenobiotics: as mediators of
cell regulation? Dijon, France, September, 1996: “Regulation of PPAR by
glucocor-ticoids and nor-epinephrine”.
168.
Tore Nilson symposium on ”Aspects of hormonal regulation of artherosclerosis”,
Stockholm, September, 1996: ”Fatty acids and gene regulation”.
169.
Steroid Receptor Superfamily Symposium, Madison, USA, September, 1996:
”Characteristics and function of the novel estrogen receptor ”.
170.
Deutsche Forschungsgemeinschaft, Symposium Hormonally Active Agents in
Food, Kaiserslautern, Germany, October, 1996: ”Novel aspects of environmentally
and dietary related ligand activated transcription factors”.
171.
University of Leicester, MRC Toxicology Unit, Leicester, U.K., February, 1997:
”What new can we learn about estrogens in light of the discovery of the novel
estrogen receptor ”.
57
172.
Workshop on ”Universities in the Cross-Streams of Globalisation and Information
Technology”, Italy, February, 1997: ”Government - Industry - University
interaction”.
173.
31st International Meeting of the European Society for Clinical Investigation
(ESCI), Kiel, Germany, March, 1997: “Functional characteristics of estrogen
receptor ”.
174.
NIH, Bethesda, USA, April, 1997: “Recent insights into mechanisms of glucocorticoid action - new crosstalk and coactivators”.
175.
Mechanisms of action of estrogens and physiological needs, Chantilly, France,
April, 1997: “ and  estradiol receptors”.
176.
Frontiers in Estrogen Action, Key West, USA, May, 1997: “Identification and
characterization of ER”.
177.
The paradoxes of growth hormone action, Fiskeb ㄰〰
“Free fatty acids - mediators of GH action”.
178.
The Endocrine Society 79th Annual Meeting, ENDO ‘97, Minneapolis, USA, June,
1997: ER: a new isoform of the estrogen receptor”.
179.
1997 Marabou symposium: Diet and genetic interactions, Stockholm, Sweden,
June, 1997: “Fatty acids and gene expression”.
180.
Paediatric Endocrinology 1997, Joint Meeting of ESPE and LWPES, in collaboration with APEG, JSPE and SLEP, Stockholm, Sweden, June, 1997: “Cloning and
function of the novel estrogen receptor ”.
181.
Eurotox Congress in collaboration with the Danish Society of Pharmacology and
Toxicology, Aarhus, Denmark, June, 1997: “Receptor mediated toxic responses”.
182.
FEBS Special Meeting, Cell Signalling Mechanisms; from membrane to nucleus,
Amsterdam, The Netherlands, June/July, 1997: “Novel insights into estrogen
mechanism of action”.
183.
XXXIII International Congress of Physiological Sciences IUPS 1997, St.
Petersburg, Russia, July, 1997: “Estrogen receptor  - tissue distribution and
functional properties”.
184.
NIEHS Conference on Estrogens in the Environment IV: Linking Fundamental
Knowledge, Risk Assessment, and Public Policy, Arlington, Virgina, USA, July,
1997: “Hormone action of a new estrogen receptor: ER-“.
185.
Gordon Research Conference on Hormone Action, New Hampshire, USA,
July/August, 1997: “Characterization of a novel estrogen receptor”.
186.
Gordon Research Conference on Hormonal Carcinogenesis, Tilton, USA,
July/August, 1997: ”Novel insights into the mechanism of action of estrogens in the
light of the discovery of a second estrogen receptor gene”.
kil, Sweden, May, 1997:
58
187.
17th International Congress of Biochemistry and Molecular Biology, San
Francisco, USA, August, 1997: “Ligand activated transcription factors in control of
cytochrome P450”.
188.
The fifth CFN Symposium, Effects of Toxicants on Gene Expression and Intracellular Signalling, Saltsjöbaden, Sweden, September, 1997: “Impact of
environmental pollutants on nuclear receptors”.
189.
Symposium on Phytoestrogen Research Methods, Chemistry, Analysis, and
Biological Properties, Tucson, Arizona, USA, September, 1997: ”The estrogen receptor and its interaction with phytoestrogens”.
190.
Workshop on Estrogen Action, New Jersey, USA, October, 1997: ”Expression and
Function of ER”.
191.
XV Congrès de la Société Francaise d’Endocrinologie, Paris, France, October,
1997: ”Cloning, expression and role of a novel estrogen receptor”.
192.
9th International CBT Symposium, Steroid and Orphan Nuclear Receptors,
Stockholm, Sweden, October, 1997: ”OR1 and PPAR - two major regulators of
lipid metabolism”.
193.
Molecular basis of sex hormone receptor function - New targets for intervention,
Berlin, Germany, October, 1997: ”Estrogen receptor ”.
194.
EMRC Workshop ”Crosstalk between steroid receptors and other transcription
factors: molecular basis for immunomodulatory and anti-inflammatory effects of
steroids”, Ottrott, Alsace, France, November, 1997: ”PPAR and OR-1: Two major
regulators of lipid metabolism”.
195.
Academy of Military Medical Sciences, Beijing, China, November, 1997: “Orphan
receptors - a rapidly developing field with nutritional implications”.
196.
Receptor Biology Roundtable, Center for Executive Education at Babson College,
Massachusetts, USA, December, 1997: ”Estrogen receptor isoforms”.
197.
Seminar at CIIT, North Carolina, USA, December, 1997: ”Nuclear receptors as
mediators of chemical-induced toxic responses: Mechanism of peroxisome
proliferator-activated receptor.
198.
Distinguished lecturer seminar, NIEHS, Research Triangle Park, North Carolina,
USA, December, 1997: ”The Estrogen Receptor Beta”.
199.
AAAS Annual Meeting and Science Innovation Exposition, Philadephila, Pennsylvania, USA, February, 1998: Cochair at the symposium ”Manipulation of Science
by Vested Interests: Money and Power versus Public Health”.
200.
University of Colorado Health Sciences Center, Department of Pathology, Denver,
USA, February, 1998: “Novel developments in nuclear receptors: postreceptor
signalling and estrogen receptor ”.
201.
Keystone Symposia on Breast and Prostate Cancer, Copper Mountain, Colorado,
USA, February, 1998: “Mechanism of Action of Estrogen Receptor ”.
59
202.
Tokyo Medical Association Meeting (Tokyo Society of Medical Science), Tokyo,
Japan, February, 1998: “New developments in nuclear receptors: crosstalk,
coactivators and orphan receptors”.
203.
Symposium for Sex Difference and Similarity Society, Tokyo, Japan, February,
1998: “New developments in nuclear receptors: crosstalk, coactivators and orphan
receptors”.
204.
1998 International Symposium on Biology of Prostate Growth, Bethesda,
Maryland, USA, March, 1998: “Estrogen  receptor in prostate”.
205.
Estrogens as initiators and promoters in breast and prostate cancer, Chantilly,
Virginia, USA, March, 1998: “Structure and properties of estrogen receptor ”.
206.
Keystone Symposia on Molecular & Cellular Biology, Nuclear Receptor Gene
Family Conference, Lake Tahoe, Nevada, March/April, 1998: ”Estrogen receptor 
predicted effects of estrogen”.
207.
2nd Congress of Molecular Medicine, Berlin, Germany, May, 1998: ”Biology of
the novel estrogen receptor ER”.
208.
IV European Congress of Endocrinology, Sevilla, Spain, May, 1998: ”Steroid
receptors - New dimensions”.
209.
18th Blankenese Conference, Orphan receptors and novel ligands, HamburgBlankenese, Germany, May, 1998: ”OR-1 and peroxisome proliferator-activated
receptors (PPAR) - two major regulators of lipid metabolism”.
210.
Frontiers in Estrogen Action, Rio Grande, Puerto Rico, May, 1998: ”Signalling via
estrogen receptor ”.
211.
NFOG ’98, The Federation of Scandinavian Societies of Obstetrics and
Gynecology, Århus, Denmark, May, 1998: ”Estrogen receptor : A new dimension
in estrogen receptor research”.
212.
Nordtox/NordEMS-98, The 5th Nordic Toxicology Meeting, Helsinki, Finland,
May, 1998: “In vitro studies for understanding toxic mechanisms in vivo”.
213.
European Federation of Endocrine Societies, 2nd Postgraduate Course in Molecular
and Cellular Endocrinology, Turku, Finland, June, 1998: “The steroid/thyroid
hormone receptor family”.
214.
Laboratory Medicine 98, Turku, Finland, June, 1998: “Estrogen Receptor ”.
Keynote lecture.
215.
3rd International Symposium on Women’s Health and Menopause, Risk Reduction
Strategies - Improved Quality of Health, Florence, Italy, June, 1998: “Novel
mechanisms of estrogen action” and ”Estrogen receptor  - a new hope for tissue
specific HRT”
216.
Xth Int. Congress on Hormonal Steroids, Québec, Canada, June, 1998: ”Estrogen
receptor  - a new dimension in estrogen mechanism of action”. Keynote lecture.
60
217.
Int. Congress of Toxicology, Paris, France, July, 1998: “PPAR activation and its
consequences in experimental animals”.
218.
Gordon Research Conference, New Hampshire, USA, July, 1998: “Expression and
function of the new estrogen receptor: ER”.
219.
Int. Congress of Pharmacology, München, Germany, July, 1998: ”Peroxisome
proliferator activated receptor or PPAR”.
220.
The Society for the Study of Reproduction, Texas, USA, August, 1998:
“Physiology and molecular biology of estrogen receptor “. Keynote lecture.
221.
NATO/FEBS Advanced Study Institute, International Summer School on
Molecular Mechanisms of Transcellular Signalling: From Membrane Receptors to
Trancription Factors, Spetsai, Greece, August, 1998: ”Coactivators and
corepressors in nuclear receptor function” and ”Novel insights into the role of
orphan nuclear receptors”.
222.
European Teratology Society, Stockholm, September, 1998: “Basic concepts of
hormone-receptor interactions”.
223.
3rd Int. Symp on Hormonal Carcinogenesis, Seattle, Washington, USA, September,
1998: “Estrogen receptor  - an important player in estrogen action”.
224.
Estrogens and Human Health, Urbana, Illinois, USA, October, 1998: ”Estrogen
receptors  and ”.
225.
Sex-Hormones, Their Receptors and Biological Response, Louisville, Kentucky,
USA, October, 1998: “New dimensions in estrogen action: ER”.
226.
Steroid hormone action at the turn of the century. Four decades after puff induction
by ecdysone, Marburg, Germany, October, 1998: ”Recent paradigm shifts in our
understanding of estrogen signalling”.
227.
Sex-Steroids and the Somatotropic Axis, La Playa, Naples, Florida, USA, October,
1998: ”Intracellular transacting signals”.
228.
Breast and menopause, Wroclaw, Poland, October, 1998: “Estrogen receptor ”.
229.
Nuclear Receptors - Minisymposium, Oslo, Norway, November, 1998:
“Introduction into the nuclear receptor field”.
230.
Sixth Annual Meeting of Japan Hormonal Steroid Society, Osaka, Japan,
November, 1998: Keynote Lecture “Estrogen receptor  - a new dimension in
estrogen mechanism of action”.
231.
The first Märta Philipson Symposium in Pediatric Research, Stockholm, December,
1998: ”Estrogen receptor : Functional role for a new estrogen receptor in mammalian development”.
232.
AACR Special Conference on The Steroid Receptor Superfamily, Indian Wells,
CA, USA, January, 1999: ”Estrogen receptor  - new exciting developments”.
61
233.
23rd International LOF-symposium on phyto-oestrogens, Gent, Belgium, January,
1999: ”The estrogen receptor  and its interaction with phytoestrogens”.
234.
ILSI Health and Environmental Science Institute, Nassau, Bahamas, January, 1999:
”Nuclear Receptors”.
235.
Endocrine Disruptors, Keystone, Lake Tahoe, USA, February, 1999: ”Properties,
distribution & function of ER”.
236.
Women’s Health Roundtable, Pasadena, USA, February, 1999: Estrogen receptors
and other nuclear receptors”.
237.
Estrogen and progesterone receptors and their ligands, Society for Gynecologic
Investigation, Atlanta, USA, March, 1999: ”Estrogen Receptors: Alpha and Beta”.
238.
The 4th Congress of the European Society for Gynecologic and Obstetric
Investigation, Madonna di Campiglio, Italy, March, 1999: ”New dimensions in
estrogen mechanism of action offer new hopes for therapy of diseases in the
postmenopausal woman”.
239.
Frontiers in Estrogen Action, Dana Point, California, USA, April, 1999: ”The
nuclear receptors”.
240.
18th Joint Meeting of the British Endocrine Societies, Insulin resistance and
cardiovascular disease: mechanisms and consequences, Bournemouth, UK, April,
1999: “Nuclear receptors involved in lipid metabolism: PPAR, ER, OR-1 and
RLD-1”.
241.
German Society of Endocrinology and German Society of Human Genetics,
International Symposium on Breast and Prostate Cancer: Genes, Hormones and the
Environment, Casle Elmau, close to Garmisch-Partenkirschen, Germany, April,
1999: ”Recent advances in our understanding of nuclear receptor action”.
242.
Keystone Symposium on The PPARs: Transcriptional links to obesity, diabetes and
cardiovascular disease, Keystone Resort, Colorado, April/May 1999: ”Downstream
Modulators of PPAR Action”.
243.
Endothelial derived vasoactive substances and free radicals in perinatal biology,
NIH, Washington, May 1999: “Estrogen receptors - current concepts”.
244.
Directors Seminar, NIH, Washington, May 1999: ”New dimensions in nuclear
receptor signaling”.
245.
EMBO Workshop, Steroid and Nuclear receptors, Villefranche, France, May 1999:
“Biology and mechanism of action of estrogen receptor ”.
246.
Int. Conference on Diet and Prevention of Cancer, Tampere, Finland, May/June
1999: “ER - an antioxidant receptor”.
247.
Gordon Conference on Mammary Gland Biology, Hennecker, New Hampshire,
USA, June 1999: ”ER: New excitement”.
62
248.
XIIIth International Symposium on Gnotobiology, Djurönäset, Stockholm, June
1999: Steroid hormones, nutrients, nuclear receptors and coactivators – important
players in control of gene expression”.
249.
Nobelsymposium 113, “Estrogens and women’s health – benefit or threat?”,
Karlskoga, Sweden, June/July 1999: “ER - a new paradigm in estrogen
mechanism of action”.
250.
Gordon Conference Research on Hormonal Carcinogenesis, New Hampshire, USA,
August 1999: “Estrogen receptor : structure and function”.
251.
11th International Conference on Cytochrome P450, Sendai, Japan, August 1999:
“Nuclear receptors – and update”.
252.
Japanese Endocrine Disruptor Research Project, Tokyo, Japan, September 1999:
“ER - a new dimension in understanding of estrogen action”.
253.
6th International Congress on Hormones and Cancer, Jerusalem, Israel, September
1999: “Recent advances in our understanding of the respective biological roles of
estrogen receptor  and estrogen receptor ”.
254.
Neuronal and cognitive effects of oestrogens, London, England, September 1999:
“New horizons in estrogen mechanisms of action – estrogen receptor ”.
255.
ECCO10 – the European Cancer Conference, Vienna, Austria, September 1999:
“Estrogen receptor beta – new developments”.
256.
International workshop: Estrogens and Male Reproduction (EMR), Isola Capo
Rizzuto, Crotone, Italy, September 1999: “The role or estrogen receptor beta in
male reproductive tissues”.
257.
The 9th International Menopause Society World Congress on the Menopause,
Yokohama, Japan, October 1999: “ER - new dimensions in estrogen mechanism
of action”.
258.
Svenska Mässan, “From Idea to Blockbuster”, Gothenburg, November 1999:
“Novel nuclear receptors – a paradigm shift in drug development”.
259.
SERMs: Implications for Prevention and Treatment of Breast Cancer, Philadelphia,
USA, November 1999: “ER: More Surprises”.
260.
National Institutes of Health, Menopause and Women’s Health – a Global
Approach, USA, November 1999: “Physiological role of estrogen and estrogen
receptors"”
261.
2nd Biennial International Meeting Flemish Gyneacological Oncology Group,
Brussels, Belgium, December 1999: “New insights in ER research – The ER “.
262.
International Symposium on Induction of Drug Metabolism From Molecular
Mechanisms to Drug Approval, Stockholm, Sweden, December 1999: “Recent
advances in our understanding of receptor mediated induction of drug-metabolizing
enzymes”.
63
263.
The Second International Symposium on: The Molecular Biology of Breast Cancer,
Lillehammer, Norway, March 2000: “Estrogen receptors  and  in the rodent
mammary gland”.
264.
Congres Infertiliteit, gynaecologie en obstetrie anno 2000, Rotterdam, Netherlands,
March 2000: “Estrogen receptors; modulation and clinical practise".
265.
Estrogens: From research to clinical practice (Hormone-dependent cancers and
menopause), Montpellier, France, March 2000: “ER - a paradigm shift in our
understanding estrogen action”.
266.
Keystone Symposia, Nuclear Receptors 2000, Steamboat Springs, Colorado, USA,
March 2000: “ER - Surprises never end”.
267.
Sixth International Stockholm/Springfield Symposium on Advances in Alzheimer
Therapy, Stockholm, Sweden, April 2000: “Roles of estrogen receptor  in the
CNS”.
268.
Nuclear Receptors in the Brain, Potential targets for therapeutic agents, Oegstgeest,
The Netherlands, April 2000: Keynote lecture: “News and views on nuclear
receptors”.
269.
4th Annual Frontiers in Estrogen Action, Palm Beach, Florida, USA, April 2000:
Coorganizer and cochairman.
270.
27th European Symposium on Calcified Tissues, Tampere, Finland, May 2000:
Keynotelecture: “Biological role of ER and ER“.
271.
Estrogens: bone and vascular targets, Paris, France, May 2000: “Estrogen receptor 
- a paradigm shift in understanding estrogen action”.
272.
SFT seminar on Phytoestrogens, Stockholm, Sweden, May 2000: “A paradigm shift
in our understanding of estrogen action”.
273.
Swiss Bone and Mineral Society, Basel, Switzerland, May 2000: “ER - a new
dimension in estrogen action”.
274.
Int. Conf. on the Female Reproductive Tract, Frauenwörth, Germany, May 2000:
“Estrogen receptor  - role in reproduction”.
275.
Annual Meeting of the German Endocrine Society, München, Germany, June 2000:
“New dimensions in estrogen receptors’ mechanisms of action”.
276.
6th Reisenburg International Symposium, Thyroid 2000: From bench to bedside,
from gene to patient, Reisenburg, Germany, June 2000: “Nuclear receptors in
control of lipid homeostasis”.
277.
ASPET, Burroughs Wellcome Fund Lecture, Boston, USA, June 2000: “Estrogen
receptor  - A paradigm shift in understanding estrogen action”.
278.
7th Nordic Nutrition Congress, Mariehamn, Åland, June 2000: “ Nutrients in
control of gene regulation”.
64
279.
Hormone-dependent Cancers and Nuclear Receptors, Saitama, Japan, June 2000:
“Role of estrogen receptor  and  in steroid hormone-dependent tissues and
cancers”.
280.
International Meeting on Women’s Health and Menopause, NIH, Washington D.C.,
USA, July 2000: “Physiological Role of Estrogen and Estrogen Receptors”.
281.
14th Ecdysone Workshop, Rapperswil, Switzerland, July 2000: “On a paradigm
shift in our understanding of estrogen mechanism of action: Discovery of estrogen
receptor “.
282.
VIth International Conference on Hormones, Brain and Behavior & The Society for
Behavioral Neuroendocrinology, Madrid, Spain, August 2000: Keynote Lecture
“Recent developments in our understanding of estrogen action: Estrogen Receptor
“.
283.
FEBS Advanced Study Institute, International Summer School on New dimensions
in the regulation of gene expression, Spetses, Greece, August 2000: “Novel
mechanisms in estrogen signalling” and “Nuclear receptor regulated lipid
homeostasis”.
284.
Third Annual Symposium on “Functional genomics – the human touch”,
Gothenburg, Sweden, August 2000: “Potential of genomics for diagnosis and drug
development – the example of the steroid receptor superfamily”.
285.
EUROTOX 2000, XXXVIII European Congress of Toxicology, London,
September, 2000: “The role of the ER in oestrogen mediated carcinogenesis”.
286.
A Joint International Symposium arranged by the Center for Biotechnology (CBT),
Karolinska Institutet and EUROSTERONE in collaboration with the Summer
University of Southern Stockholm, “Nuclear Receptors in Health and Disease”,
Huddinge, Sweden, September, 2000: “Estrogen receptor  - A paradigm shift in
understanding estrogen action”.
287.
Pannon Symposium, Tissue-selective estrogen action: from basic science to the
clinical practice, Pécs, Hungary, September, 2000: Keynote lecture “Estrogen
receptor-: A paradigm shift in understanding estrogen action”.
288.
BioTech Forum, Älvsjömässan, Stockholm, Sweden, October, 2000: “Rational
drug design based on steroid hormones and their receptors and the interaction
between academic research and KaroBio AB”.
289.
Cinquièmes Journées Européennes de la Sociéte Francaise de Gynécologie, Paris,
France, October, 2000: “Estrogen receptors”.
290.
Cardiovascular Disease and Hormone Replacement Therapy, IMS Workshop Royal
Society of Medicine, London, U.K., October, 2000: “Estrogen receptors”.
291.
E.hormone 2000 – the cutting edge of endocrine disrupter research, Tulane
University, New Orleans, U.S.A., October, 2000: “Estrogen receptor  - a
paradigm shift in our view on estrogen signaling and endocrine disruption”.
65
292.
Keynote Lecture at Hormones and cancer 2000 and Aromatase 2000 and the 3rd
generation, Port Douglas, Queensland, Australia, November, 2000: “Estrogen
receptor – a paradigm shift in understanding estrogen action”.
293.
Keynote Lecture at Garvan Symposium “Estrogens & Womens Health”, Sydney,
Australia, November, 2000: “Mechanisms of estrogen action: the role of ERbeta”.
294.
Keynote Lecture at Steroid receptor and cell signaling, Cincinnati, University of
Cincinnati, USA, November, 2000: “Estrogen receptors and control of
proliferation”.
295.
European Medal Lecture. 191st Meeting of the Society for Endocrinology, London,
U.K., November, 2000: “Estrogen receptor  - a paradigm shift in understanding
estrogen action”.
296.
23rd Annual San Antonio Breast Cancer Symposium, San Antonio, Texas, USA,
December, 2000: “ER and ER : “The Yin-Yang principle of estrogen action”.
297.
1st Meeting of the Network “Environmental Estrogens and their Effects in Health
and Disease”, Athens, Greece, January, 2001: “The mechanism of action of
estrogens – The role of ER “
298.
Mayo Clinic, Rochester, USA, February, 2001: “Estrogen Receptor Beta – a
Breakthrough in Understanding Estrogen Signaling”.
299.
II International Symposium of the Portuguese Menopause Society, Menopause:
Hormones and Cancer, Lisbon, Portugal, March, 2001: “Estrogen receptors and
Breast Cancer”.
300.
Disorders of the Prostate. Advances in Basic Mechanisms and the Implications for
Clinical Management, Castres, France, March, 2001: “Oestrogen receptor beta
knock out leads to hyperplasia in the ventral prostate”.
301.
Experimental Biology 2001, The American Association of Immunologists,
Orlando, Florida, USA, March/April, 2001: “Molecular aspects of estrogen
receptors alpha and beta”.
302.
5th Annual Frontiers in Estrogen Action, County Clare, Ireland, April, 2001: “ER
biology: New Frontiers”.
303.
EMBO Workshop on Nuclear Receptor Structure and Function, Erice, Italy, May,
2001: “Novel aspects on estrogen signaling”.
304.
4th International Symposium on Women’s Health and Menopause, Washington DC,
USA, May, 2001: “Estrogen signaling – New Paradigms”.
305.
Eukaryotic Transcription: From mechanism to function, Turku, Finland, June,
2001: “Estrogen Receptors”.
306.
Neuroendocrine Workshop on Hormones, Mood and Behavior, Breckenridge,
Colorado, USA, June, 2001: “Estrogen receptor ”.
307.
FASEB Summer Research Conference Program “Steroids and Bone”, Whitefish,
Montana, USA, June, 2001: “ER-ER interplay in estrogen action”.
66
308.
A Eurosterone Thematic Conference: Steroid signalling: New Frontiers, Edinburgh,
Scotland, June, 2001: “New Frontiers in estrogen signalling”.
309.
XIth International Congress on Genes, Gene Families and Isozymes; Stockholm,
Sweden, June/July, 2001: “The nuclear receptor super gene family – developments
and highlights”.
310.
17th Annual meeting of the European Society of Human Reproduction and
Embryology, Lausanne, Switzerland, July, 2001: “Transgenic models in
reproductive research”.
311.
Bone and Tooth Society, Annual Meeting, Warwick, UK, July, 2001: “Regulation
of transcription by different estrogen receptors”.
312.
15th Annual Symposium on The Long-Term Effects of Estrogen Deprivation,
Bermuda, July, 2001: “Phenotypes of ER knockout mice”.
313.
7th International Summer School Behavioral Neurogenetics, Lake Erken, Norrtälje,
Sweden, July, 2001: “A tale of two estrogen receptors”.
314.
IMCB, Singapore, July, 2001: “New paradigms in estrogen signalling – estrogen
receptor beta” and “LXRalfa and LXRbeta – two novel and important regulators of
cholesterol homeostasis”.
315.
Nuclear Receptors – Recent Developments, Oslo, Norway, August, 2001: “New
paradigms in estrogen signalling”.
316.
XXIII Congress of the European Society of Cardiology together with the 36th
Annual General Meeting of the Association for European Paediatric Cardiology,
Stockholm, September, 2001: “Update on estrogen receptors”.
317.
The Charles Brenton Huggins Memorial Symposium, Chicago, USA, September,
2001: “ER-beta: A receptor with many faces”.
318.
XXVIth European Symposium on Hormones and Cell Regulation, Mont Ste Odile,
September, 2001: “On the role of estrogen receptor beta in reproduction” and
“LXRs”.
319.
Benzon Symposium No 48: Drug Metabolism Regulation and Importance,
Copenhagen, September, 2001: “Molecular mechanisms of CYP induction”.
320.
Medicon Valley BioConference 2001, Copenhagen, Denmark, September 2001:
“Nuclear receptors as target for drug development – A scientifically and
commercially hot area that may serve as a role model for a new paradigm in
academic research”.
321.
8th ICEM, Shizuoka, Japan, October 2001: Plenary lecture “Nuclear receptor –
environment interactions”.
322.
Science in Japan Forum, Stockholm, October 2001: “Recent advances in
understanding nuclear receptors”.
323.
3rd Biennial International Meeting of the Flemish Gynaecological Oncology Group,
Endocrine treatment and prevention of breast and gynaecological cancers, Brussels,
67
Belgium, November 2001: “The latest on ER beta in gynaecological and breast
cancers”.
324.
Workshop on Genomic vs non-genomic steroid action: Encountered or unified
views, Madrid, Spain, December 2001: “The nuclear-receptor interacting proteins”.
325.
First International Nuclear Receptor Meeting in Japan, Kyoto, Japan, March 2002:
“An update on the biology of estrogen receptor beta”.
326.
2nd Annual Lectureship inWomen’s Health Research “From estrogen receptors to
management of menopause”, Washington, USA, March 2002: “Estrogen receptor –
A multifaceted player”.
327.
Lecture at Chinese Academy of Medical Sciences, Beijing, China, April 2002:
“Recent advances in our understanding of estrogen signalling pathways”.
328.
6th Annual Frontiers in Estrogen Action, Amelia Island, Florida, April 2002:
“Update on the biology of ER”.
329.
7th Congress of the European Society of Contraception, Genova, Italy, April 2002:
“Steroid receptors”.
330.
Keystone meeting on Nuclear Receptor Superfamily, Snowbird, Utah, USA, April
2002: “On the role of ERbeta in the CNS”.
331.
Swiss National Research Programme (NRP) 50 “Endocrine Disruptors”, Zürich,
Switzerland, April 2002: “Steroid receptors and transcription mechanisms: action
of endocrine disruptors”.
332.
Hormones and Genome: Basic research towards improvement of diagnostic and
therapeutic medicine, Blaubeuren/Ulm, Germany, May 2002: “New paradigms in
estrogen signaling – ER as the Deus ex machina”.
333.
Fourth Annual Symposium on Developmental & Molecular Toxicology,
Development and Genetic Aspects of Breast Cancer, Madison, Wisconsin, USA,
June 2002: “Estrogen signaling – a matter of thesis and antithesis”.
334.
10th World Congress on the Menopause, Plenary lecture, Berlin, Germany, June
2002: “Estrogen receptor – a multifacetted player”.
335.
XIVth World Congress of Pharmacology, Plenary lecture, San Fransisco, USA,
July 2002: “Estrogen receptors”.
336.
Conférence du Centre de recherche, Quebec, Canada, July 2002: “Estrogen receptor
 - an important and multifacetted player in estrogen signaling”.
337.
National Cancer Centre, Tokyo, Japan, July 2002: “Novel aspects on estrogen
signaling and hormone dependent cancer”.
338.
14th International Symposium on Microsomes and Drug Oxidations (MDO 2002),
Sapporo, Japan, July 2002: “Crosstalk between PPAR and LXR: Two major
regulators of lipid metabolism”.
68
339.
Summer School/Bregenz 2002, “From genes via endocrine models to patients”,
Bregenz, Austria, July 2002: “ER , ER and more” and “ED interactions with ER
and ER”.
340.
International Summer School on Neurotrophin and Nuclear Receptors: From
Molecules to Behaviour, Lake Erken, Norrtälje, Sweden, August 2002: “Estrogen
receptors: alpha and beta”.
341.
Nuclear Receptors 2002 - A Joint International Symposium arranged by the Center
for Biotechnology (CBT), Karolinska Institutet in collaboration with the Summer
University of Southern Stockholm, Huddinge, Sweden, August 2002: “ERbeta as a
regulator of cellular proliferation”.
342.
The 5th International Congress of Neuroendocrinology, Bristol, U.K.,
August/September 2002: “Genomic and non-genomic actions of steroids”.
343.
Nuclear receptors and disease, Göteborg, Sweden, September 2002: “Sterol
homeostasis controlled by nuclear receptors”.
344.
30th Conference of the European Teratology Society in conjunction with the
symposium Adverse effects of endocrine disruptors, Hannover, Germany,
September 2002: “Mechanisms of endocrine signaling”.
345.
26th Congress of the Société Internationale d’Urologie, Stockholm, Sweden,
September 2002: State-of-the-Art-Lecture: “The role of estrogen-receptor beta in
control of prostate growth”.
346.
ENEA 2002 Münich, 10th Meeting of the European Neuroendocrine Association,
Münich, Germany, September 2002: “Estrogen receptors”.
347.
European Respiratory Society, Annual Congress 2002, Stockholm, Sweden,
September 2002: “Glucocorticoid receptors and cell signalling (overview talk)”.
348.
Molecular mechanisms as targets in prostatic diseases, Liverpool, UK, September
2002: “The role and function of ER-beta in the development of prostate cancer”.
349.
2nd European Congress of Andrology, Malmö, Sweden, September 2002: “A novel
endocrine pathway in the prostate, ER, AR, 5 -androstane-3, 17-diol, and
CYP7B1, regulates prostate growth”.
350.
International Society for the Study of Women’s Sexual Health, Annual Meeting
2002, Vancouver, Canada, October 2002: State of the Art Lecture, “New paradigms
in understanding estrogen signaling”.
351.
Tianjin TEDA Watson Biopark Development Conference, Tianjin, China, October
2002: “Recent advances in our understanding of nuclear receptor action”.
352.
e.hormone 2002, New Orleans, USA, October 2002: “Environmental signals:
Multiple receptors & multiple inputs”.
353.
Women’s Health Special Interest Group (WHSIG), NIH; Washington, USA,
November 2002: “Estrogen receptors – from molecular biology ot therapeutics”.
69
354.
Burroughs Wellcome Fund Visiting Professorship In the Basic Medical Sciences,
University of Texas Medical Brand School of Medicine, Houston, Texas, USA,
November 2002: “A new paradigm in estrogen signaling provided by the dynamic
interplay between ERalpha and ERbeta”.
355.
Biomedicum Helsinki Seminars: Frontiers in Medicine, Helsinki, Finland,
November 2002: “Nuclear receptors and regulation of cholesterol homeostasis”.
356.
Fourth Amazon Project Conference, Innaovative Strategies and Perpectives in
Cancer Care, Palermo, Italy, November 2002: “The novel estrogen receptor beta –
possible implications for breast cancer”.
357.
British Pharmacological Society Wintermeeting, Nuclear receptors: targets for new
therapies, Brighton, U.K., January 2003: “Oestrogen receptors”.
358.
Symposium Regulation of cell signalling by estrogens and phytoestrogens,
McDowell Lecture in Physiology, London, U.K., January 2003: “Estrogens – how
do they work?”.
359.
Distinguished Guest for 2003 in the Molecular and Cellular Biology Department at
Baylor College of Medicine, Houston, Texas, U.S.A., February 2003: “A new look
on estrogen signaling”.
360.
Ernst Schering Research Foundation, Workshop 46, New molecular mechanisms of
estrogen action and their impact on future perspectives in estrogen therapy, Berlin,
Germany, March 2003: “Novel functions of ER as revealed by studies of
phenotypes of ER K.O.-mice”.
361.
International Group on Insulin Secretion, Novel Factors in the Regulation of -cell
function, St. Jean-Cap-Ferrat, March 2003: Keynote Lecture, “Frontiers in nuclear
receptors research”.
362.
On Target 2010: The Future of Medicines, Stockholm, Sweden, April 2003: “The
academic research perspective”.
363.
Chairman at the 7th Annual Frontiers in Estrogen Action, The Homestead, Hot
Springs, Virginia, April 2003.
364.
6th European Congress of Endocrinology, Lyon, France, April 2003: Plenary
Lecture, “Role of estrogen receptors: lessons from knock-out mice”.
365.
Calcified Tissue International, Rome, Italy, May 2003: Plenary Lecture,
“Modulation of estrogen action by ER isoforms”.
366.
Novel approaches to treatment in hormone-sensitive breast cancer, London, U.K.,
May 2003: “Elucidation of ER function in breast cancer”.
367.
Utrecht Graduate School of Developmental Biology, Utrecht, The Netherlands,
June 2003: “New paradigms in estrogen signaling”.
368.
2nd Dutch Endo-Neuro-Psycho meeting, Doorwerth, The Netherlands, June 2003:
Marius Tausk Lecture, “New paradigms in estrogen signaling”.
70
369.
EMBO Conference, Biology of Nuclear Receptors, Villefranche-sur-Mer (Nice),
France, June 2003: “Antiproliferative actions of estrogen receptor ”.
370.
Special Symposium on estrogen receptors, Los Angeles, USA, June 2003:
“Estrogen receptor-beta – A paradigm shift in understanding estrogen signaling”.
371.
Allosteric Mechanisms of Signal Transduction, Paris, France, June 2003: “Estrogen
signaling – importance of conformational changes in estrogen receptor action”.
372.
European Code against cancer, Clinical Cancer Research in Europe, Milan, Italy,
June 2003: “Oestrogen signaling and cancer”.
373.
Fourth International Symposium on Hormonal Carcinogenesis, Valencia, Spain,
June 2003: “A novel mechanism for control of prostate growth”.
374.
Special FEBS 2003 Meeting on Signal Transduction; Signal transduction: from
membrane to gene expression, from structure to disease, Brussels, Belgium, July
2003: Datta Lecture “Update on estrogen signaling”.
375.
19th Ernst Klenk Symposium, Transcriptional and other regulatory mechanisms of
lipid metabolism, Cologne, Germany, July 2003: “Some phenotypes of LXR KO
mice”.
376.
HLSC 2nd event, Hormones and Genome, Molecular Mechanisms in Metabolic
Diseases: Obesity, Diabetes Type 2, Lipid disorders and Atherosclerosis – Basic
Science towards Clinical Application, Ulm, Germany, July 2003: “Some
phenotypes of LXR KO mice”.
377.
Summer School on Endocrinology, Bregenz, Austria, July 2003: “Estrogen
receptors and metabolic syndrome”.
378.
Nobel Conference No 40, Transcriptional control of lipid homeostasis, Stockholm,
Sweden, August 2003: “LXR and control of lipid homeostasis”.
379.
FEBS Advanced Study Institute, International Summer School, From transcription
to physiology: Regulation of gene expression and protein function in an integrated
context, Spetses, Greece, September, 2003: “Mechanisms of estrogen action” and
“Insight into the biology of estrogen and Liver X receptors by studying knock-out
mice”.
380.
8th Nottingham International Breast Cancer Conference, Nottingham, U.K.,
September, 2003: “Development and an overview of ER“.
381.
Lecture at the University of Mainz, Institute of Toxicology, Mainz, Germany,
September, 2003: “New views on estrogen signaling”.
382.
Rudbeck seminars, Uppsala University, September, 2003: “New understanding of
estrogen action”.
383.
The Endocrine Society: The Role of Nuclear Receptors in Cardiovascular Disease,
San Diego, October, 2003: “Estrogens and the Immune System: Novel Lessons
from ERalfa and ERbeta KO Mice”.
71
384.
The 2nd International Symposium of Gender Related Medicine at Centre of Gender
Related Medicine, Karolinska Institutet, Stockholm, Sweden, October, 2003: “New
paradigms of estrogen signalling – genderaspects”.
385.
Maturitas Master Class, Lisbon, Portugal, October 2003: “Steroid receptors” and
“Specific alpha and beta ER-ligands”.
386.
International School of Medical Science, 117th Advanced Course on Signal
Transduction and Communication in Cancer Cells, Erice, Italy, October 2003:
“Estrogen Receptor Beta in Development and Cancer”.
387.
Eleventh Annual Nuclear Receptor Symposium, Nuclear Receptors: Discovery,
Biology, and Therapy, Stevenage, U.K., October, 2003: “Novel views on estrogen
signaling”.
388.
13th Annual Meeting of the Dutch Society for Calcium and Bone Metabolism,
Zeist, The Netherlands, October, 2003: “Estrogen signaling – a case of yin and
yang”.
389.
The 6th U.S.- Taiwan Neuroscience Symposium, Estrogen actions in the brain,
New Orleans, USA, November, 2003: “ERbeta in the nervous system”.
390.
Bengt E Gustafsson Symposium, Microbial Ecology in Health & Disease, Born
germfree – microbial dependent, Stockholm, November 2003: “Metabolism”.
391.
Jensen Symposium, Nuclear Receptors and Endocrine Disorders, Cincinnati, USA,
December 2003: “Estrogens and diseases of brain and the immune system”.
392.
Boosting Innovation from Research to Market, Bryssel, Belgium, December 2003:
“Academy-industry interactions at the Novum Campus in Stockholm”.
393.
The Biotechnology, the Capital and the Brain – The Mixing Chemistry of
Bioeconomy, Beijing, China, December 2003: “Nuclear Receptors – From
Academia to Commercial Application”.
394.
Rui Jin Hospital, Shanghai, China, December 2003: “Yin-yang of estrogen
signaling”.
395.
Workshop Nuclear Receptors, Leiden, Netherlands, January 2004: “Estrogen
receptor-beta – a multifunctional transcription factor”.
396.
Updates in Infertility Treatment, Marco Island, Florida, USA, January 2004:
“Novel functions of estrogen receptor beta”.
397.
A. I. Virtanen Institute Research Seminars, Kuopio, Finland, January 2004: “A new
look upon estrogen signaling”.
398.
Keystone Symposia on Nuclear Receptors: Orphan Brothers, Keystone Resort,
Colorado, February, 2004: “New roles of estrogen receptor ”.
399.
Umeå University, March, 2004: “Estrogen signaling – an area of rapid development
and relevance”.
72
400.
ERPM 2004, Stéroïdes sexuels: le point sur l’action des estrogènes et des
progestatifs. Montpellier, France, March/April 2004: “Effects of ER on the CNS”.
401.
55. Mosbacher Kolloquium: How nutrients influence gene activity, Mosbach,
Baden, Germany, April 2004: “On the role of estrogen receptors and liver X
receptors in lipid metabolism”.
402.
15th Symposium on Growth Hormone and Endocrinology, Malta, April 2004:
“Estrogen receptor beta regulates epithelial cell differentiation in the mouse ventral
prostate”.
403.
European Atherosclerosis Society, 74th EAS Congress, Seville, Spain, April 2004:
“Estrogen signaling and the cardiovascular system – some new angles”.
404.
5th International Symposium on Women’s Health and Menopause, Florence, Italy,
April 2004: “ER - A multifunctional regulator of women’s health”.
405.
Hormones and the Genome, HLSC 3rd event, Endocrine malignancies and
autoimmunity, Molecular biological events and targets for clinical application,
Ulm, Germany, April 2004: “Estrogen signaling and the immune system – new
excitements”.
406.
Nuclear receptors, transcription, and cancer symposium, University of Virginia,
Virginia, USA, May 2004: “A new look at estrogen signaling”.
407.
Eli Lilly, Indianapolis, Illinois, USA, June 2004: “Recent excitements in estrogen
signaling”.
408.
Breast Cancer Meeting, New Orleans, USA, June 2004: “New vistas in estrogen
signaling”.
409.
Environmental and Endocrine Signaling, A Satellite Symposium preceding the
annual Society of Endocrinology Meeting, New Orleans, USA, June 2004:
“Nuclear receptors as signal sensors”.
410.
Workshop “Food safety and quality: state of research in the Southern
Mediterranean Agronomic Studies”, Bari, Italy, July 2004: “Projet CE:
CASCADE”.
411.
MDO 2004, 15th International Symposium on Microsomes and Drug Oxidations:
Chemical biology in the postgenomic era; new approaches and applications, Mainz,
Germany, July 2004: “Role of P450 in steroid hormone action”.
412.
Seventh International Symposium on Neurobiology and Neuroendocrinology of
Aging, Bregenz, Austria, July 2004: “The role of the estrogen receptor in
neuroprotection”.
413.
Summer School on Endocrinology, Nuclear Receptors, Endocrine Disruptors and
Metabolic Effects, Bregenz, Austria, July 2004: “ER and immunology”.
414.
37th Annual Meeting of the Society for the study of reproduction, Vancouver,
British Columbia, Canada, August 2004: “Targeting cancers by estrogens and its
analogs”.
73
415.
XVIII World Congress International Society for Heart Research, Brisbane,
Australia, August 2004: Estrogen derivatives in cardiovascular disease-old
questions, new answers; “New paradigms in estrogen signaling with particular
reference to cardiovascular function”.
416.
XVIIIth International Symposium on Medicinal Chemistry, Copenhagen, Denmark,
August 2004: “Recent excitements in drug development based on novel insights in
estrogen signaling”.
417.
UT Forum 2004 in Sweden, Medical and Life Sciences, “Molecular Medicine and
Its Recent Advances”, Stockholm, Sweden, August 2004: “New vistas in estrogen
signaling: Therapeutical implications”.
418.
ESPE 18th Summer School 2004, “Estrogen receptor”, Ramsach, Switzerland,
September 2004: “Estrogen receptor”.
419.
55th Annual Meeting of the European Association for Animal Production, Bled,
Slovenien, September 2004: “Estrogen signaling in the mammary gland”.
420.
43rd Annual Meeting of the European Society for Pediatric Endocrinology, Basel,
Switzerland, September 2004: “New paradigms in estrogen signaling and their
clinical implications”.
421.
CASCADE Summer School on Nuclear Receptors, ENS Lyon, Lyon, France,
September 2004: “LXR and ER signaling”.
422.
Inaugural COST 926 Conf. Eur. Workshop on Cellular Responses to bioactive
plant compounds – implications for human health, Budapest, Hungary,
September/October 2004: Keynote lecture “Estrogen signaling and cancer
prevention”.
423.
Nuclear Receptors 2004 - An International Symposium arranged by the Center for
Biotechnology (CBT), Karolinska Institutet, Huddinge, Sweden, October 2004:
“Estrogen signaling in new light”.
424.
Annual Bristol-Myers Squibb/Mead Johnson Nutrition Award Symposium, New
York, USA, October 2004: “New paradigms in estrogen signalling”.
425.
China TEDA Bioforum, Tjianjin, China, October 2004: “Nuclear Receptors, A
rapidly developing field”.
426.
e.hormone 2004, Tulane University, New Orleans, USA, October 2004: “New
surprises in estrogen signaling”.
427.
Nuclear Receptors and Genomic Medicine, Saitama Medical School, Saitama,
Japan, November 2004: “A new look at estrogen signaling”.
428.
National Cancer Center Research Institute, Tokyo, Japan, November 2004: “ER
and cancer”.
429.
Tokyo University, Inst. of Molecular and Cellular Biosciences, Japan, November
2004: “Novel concepts in estrogen signaling open up new therapeutical
possibilities in many areas”.
74
430.
Biomedicum Helsinki, Helsinki, Finland, November 2004: “New paradigms in
estrogen signaling open up novel pharmaceutical approaches for several diseases”.
2004-12-03/MA