The Edinburgh
Tommy’s Centre for
Maternal and Fetal Health
Centre for Reproductive Biology
University of Edinburgh
Annual Report: October 2008 – September 2009
Impact Factor Report
Contents
Page
1. Research Outputs October 2008 –
September 2009 3
1.1. Peer reviewed scientific papers with
Impact factor
3
1.2 Other publications: Book Chapters
10
1.3 Patents
11
1.4 Training
11
1.4.1 Postgraduate degrees awarded this year
11
1.4.2 Current PhD Students supervised by
‘Tommy’s’ Principal Investigators.
11
1.5 Invited and plenary lectures; International and
National Conferences Attended and Awards
13
1.5.1 Plenary and Invited lectures
13
1.5.2 Awards to trainees/postdoctoral fellows
16
1.6 Other Notable Contributions from the Edinburgh Tommy’s group
16
1.6.1 Book Editorships
16
1.6.2 Editorial Board Membership
16
1.6.3 Memberships of other relevant
scientific committees
17
1.7 Recent Media - Radio, Television, online and
Newspaper interviews 17
1.8 Edinburgh Tommy’s Centre Research
Funding 2009
19
Edinburgh Tommy’s Centre for Maternal and Fetal Health. Impact Factor Report
1
1. Research Outputs October 2008 – September 2009
1.1. Peer reviewed scientific papers with Impact factor:
Journal Impact Factor Authors / Title
Lancet
28.409Norman JE, Mackenzie F, Owen P, Mactier H, Hanretty K, Cooper
S, Calder A, Mires G, Danielian P, Sturgiss S, MacLennan G,
Tydeman G, Thornton S, Martin B, Thornton JG, Neilson JP, Norrie
J. Progesterone for the prevention of preterm birth in twin
pregnancy (STOPPIT): a randomised, double-blind, placebocontrolled study and meta-analysis 2009; 373: 2034–40.
British Medical
12.827
Journal
Carlin A, Norman JE, Cole S, Smith R. Tocolytics and preterm
labour (editorial). 2009;338:b195.
PLOS Medicine
12.185Reynolds RM, Seed P, Poston L. Response to Lawlor et al:
Exploring the Developmental Overnutrition Hypothesis Using
Parental-Offspring Associations and FTO as an Instrumental
Variable. 2008; 5(3):e33.
PLOS Medicine
12.185Norman JE, Morris C, Chalmers J. The effect of changing
patterns of obstetric care in Scotland (1980 – 2004) on rates
of preterm birth and its neonatal consequences. 2009: 6(9):
e1000153.
American 10.153
Journal of Human Genetics
Newbury DF, Winchester L, Addis L, Paracchini S, Buckingham LL,
Clark A, Cohen W, Cowie H, Dworzynski K, Everitt A, Goodyer IM,
Hennessy E, Kindley AD, Miller LL, Nasir J, O’Hare A, Shaw D,
Simkin Z, Simonoff E, Slonims V, Watson J, Ragoussis J, Fisher SE,
Seckl JR, Helms PJ, Bolton PF, Pickles A, Conti-Ramsden G,
Baird G, Bishop DV, Monaco AP. CMIP and ATP2C2 Modulate
Phonological Short-Term Memory in Language Impairment.
2009; Jul 29. [Epub ahead of print].
Diabetes
8.261Stimson RH, Andersson J, Andrew R, Redhead DN, Karpe F, Hayes
PC, Olsson T, Walker BR. Cortisol release from adipose tissue by
11β-hydroxysteroid dehydrogenase type 1 in humans. 2009; 58:
46-53.
Cancer Research
7.514Wallace AE, Sales KJ, Catalano RD, Anderson RA, Williams
ARW, Wilson MR, Schwarze J, Wang H, Rossi AG, Jabbour
HN. Prostaglandin F2alpha-F-Prostanoid receptor signalling
promotes neutrophil chemotaxis via chemokine (CXC motif )
ligand-1 in endometrial adenocarcinoma. 2009; 69: 5726-5733.
Hypertension
7.368Reynolds RM, Walker BR, Phillips DI, Dennison EM, Fraser
R, Mackenzie SM, Davies E, Connell JM. Programming of
hypertension: associations of plasma aldosterone in adult men
and women with birthweight, cortisol and blood pressure. 2009;
53 6:932-936.
Edinburgh Tommy’s Centre for Maternal and Fetal Health. Impact Factor Report
3
Journal Impact Factor Authors / Title
Hypertension
7.368Robb AO, Mills NL, Din JN, Smith ABJ, Paterson F, Newby
DE, Denison FC. Changes in central and peripheral arterial
compliance with pregnancy. 2009; 53(6):952-8.
Diabetes Care
7.349
Goedecke JH, Dave JA, Faulenbach MV, Utzschneider KM,
Lambert EV, West S, Collins M, Olsson T, Walker BR, Seckl JR, Kahn
SE, Levitt NS. Insulin response in relation to insulin sensitivity: an
appropriate beta-cell response in black South African women.
2009; 32: 860-865.
Diabetes Care
7.349
Goedecke JH, Dave JA, Faulenbach MV, Utzschneider KM,
Lambert EV, West S, Victor H, Collins M, Olsson T, Walker BR, Seckl
JR, Kahn SE, Levitt NS. Insulin secretion in relation to insulin
sensitivity: an appropriate β-cell response in South African
women. 2009; 32 : 860-865.
Oncogene
7.216Sales KJ, Boddy SC, and Jabbour HN. F-prostanoid receptor
alters adhesion, morphology and migration of endometrial
adenocarcinoma cells. 2008; 27: 2466-2477.
FASEB J.
7.049Michailidou Z, Carter RN, Marshall E, Sutherland HG, Brownstein
DG, Owen E, Cockett K, Kelly V, Ramage L, Al-Dujaili EA, Ross M,
Maraki I, Newton K, Holmes MC, Seckl JR, Morton NM, Kenyon
CJ, Chapman KE. Glucocorticoid receptor haploinsufficiency
causes hypertension and attenuates hypothalamic-pituitaryadrenal axis and blood pressure adaptions to high-fat diet. 2008;
22: 3896-3907.
FASEB J.
7.049Evans J, Catalano RD, Brown P, Sherwin R, Critchley HOD,
Fazleabas AR, Jabbour HN. Prokineticin 1 mediates fetalmaternal dialogue regulating endometrial leukaemia inhibitory
factor. 2009; 23: 2165-2175.
FASEB J
7.049Michailidou Z, Carter RN, Marshall E, Sutherland HG, Brownstein
DG, Owen E, Cockett K, Kelly V, Ramage L, Al-Dujaili EA, Ross M,
Maraki I, Newton K, Holmes MC, Seckl JR, Morton NM, Kenyon
CJ, Chapman KE. Glucocorticoid receptor haploinsufficiency
causes hypertension and attenuates hypothalamic-pituitaryadrenal axis and blood pressure adaptions to high-fat diet. 2008;
22(11):3896-907.
4
Edinburgh Tommy’s Centre for Maternal and Fetal Health. Impact Factor Report
Journal Impact Factor Authors / Title
Journal of 6.325
Clinical Endocrinology Mattsson C, Reynolds, RM, Simonyte K, Olsson T, Walker BR
Novel Combined Receptor Antagonist Stimulation of the HPA
axis (CRASH) test identifies impaired negative feedback and
Metabolism. sensitivity to cortisol in obese men. 2009;
94(4): 1347-1352.
Journal of 6.325
Clinical
Endocrinology Metabolism
Rae M, Mohamad A, Price D, Hadoke PWF, Walker BR, Mason JI,
Hillier SG, Critchley HOD. Cortisol inactivation by 11βHSD2 may
may enhance endometrial angiogenesis via reduced
thrombospondin-1 in heavy menstruation. 2009; 94: 1443-1450.
Journal of 6.325
Clinical Endocrinology and Metabolism
Bayne RAL, Eddie S, Collins C, Childs AJ, Jabbour HN,
Anderson RA. Prostaglandin E2 as a regulator of germ cells
during ovarian development. 2009; (in press).
Journal of 6.291
Thrombosis and Haemostasis
Robb AO, Mills NL, Din JN, Cameron S, Ludlam CA, Newby DE,
Denison FC. Acute Endothelial Tissue Plasminogen Activator
Release in Pregnancy. 2009; 7:138-42.
American Journal 5.917
of Pathology Sales KJ, Grant V, Cook IH, Maldonado-Perez D, Anderson RA,
Williams ARW and Jabbour HN. Interleukin-11 in endometrial
adenocarcinoma is regulated by PGF2alpha-FP prostanoid
receptor interaction via the calcium-calcineurin-NFAT pathway
and negatively regulated by the regulator of calcineurin-1.
2009; (in press).
Molecular 5.389
Endocrinology Sai S, Esteves CL, Kelly V, Michailidou Z, Anderson K, Coll AP,
Nakagawa Y, Ohzeki T, Seckl JR, Chapman KE. Glucocorticoid
regulation of the promoter of 11β-hydroxysteroid
dehydrogenase type 1 is indirect and requires C/EBPb. 2008;
22:2049-60.
Endocrinology
4.945
Scott HM, Hutchison GR, Jobling MS, McKinnell C, Drake AJ,
Sharpe RM. Relationship between Androgen Action in the “Male
Programming Window,” Fetal Sertoli Cell Number, and Adult
Testis Size in the Rat. 2008; 149:5280-5287.
Endocrinology
4.945
Drake AJ, van den Driesche S, Scott HM, Hutchison GR, Seckl JR,
Sharpe RM. Glucocorticoids amplify dibutyl phthalate-induced
disruption of testosterone production and male reproductive
development. 2009 (in press).
Endocrinology
4.945
De Sousa Peixoto RA, Turban S, Battle JH, Chapman KE, Seckl JR,
Morton NM. Preadipocyte 11β-hydroxysteroid dehydrogenase
type 1 is a keto-reductase and contributes to diet-induced
visceral obesity in vivo. 2008; 149: 1861-1868.
Edinburgh Tommy’s Centre for Maternal and Fetal Health. Impact Factor Report
5
Journal Impact Factor Authors / Title
Endocrinology
4.945
Wamil M, Andrew R, Chapman KE, Street J, Morton NM, Seckl
JR. 7-Oxysterols modulate glucocorticoid activity in adipocytes
through competition for 11β-hydroxysteroid dehydrogenase
type 1. 2008; 149: 5909-18.
Endocrinology
4.945
Wyrwoll CS, Seckl JR, Holmes MC. Altered placental function of
11β-HSD2 knockout mice. 2008; 150:1287-93.
Endocrinology
4.945
Waclawik A, Jabbour HN, Blitek A, Ziecik AJ Estradiol-17beta,
prostaglandin E2 (PGE2) and the prostaglandin E2 receptor
are involved in PGE2 positive feedback loop in the porcine
endometrium. 2009; 50: 3823-3832.
Endocrinology
4.945
Evans J, Catalano R, Morgan K, Critchley HOD, Millar RP, Jabbour
HN. Prokineticin 1 signalling and gene regulation in early
human pregnancy. 2008; 149: 2877-2887.
Endocrinology
4.945
Denison FC, Battersby S, King AE, Szuber M, and Jabbour HN
2008 Prokineticin 1 – a novel mediator of the inflammatory
response in third trimester human placenta. 2008; 149: 34703477.
BBA – Molecular 4.893
Cell Research Maldonado-Perez D, Brown P, Morgan K, Millar RP,
Thompson EA, Jabbour HN. Prokineticin 1 modulates IL-8
expression via the calcineurin/NFAT signalling pathway. 2009;
1793: 1315-1324.
Journal of 4.679
Psychiatric Research Yehuda R, Bierer LM, Andrew R, Schmeidler J, Seckl JR.
Enduring effects of severe developmental adversity, including
nutritional deprivation, on cortisol metabolism in aging
Holocaust survivors. 2009; 43:877-83.
Diabetes, 4.259
Obesity
Metabolism
Strachan MW, Reynolds RM, Frier BM, Mitchell RJ, Price JF.
Metabolism. The Role of Metabolic Derangements and
Glucocorticoid Excess in the Aetiology of Cognitive Impairment
in Type 2 Diabetes. Implications for Future Therapeutic
Strategies. 2009; 11(5):407-414.
International 4.021
Journal of Andrology MacLeod DJ, Sharpe RM, Welsh M, Fisken M, Scott HM, Hutchison
GR, Drake AJ, van den Driesche S. Effect of disrupted androgen
production or action in the masculinisation programming
window on the development of male reproductive organs.
2009 (in press).
Psychoneuro-
3.788
endocrinology
Yehuda R, Bierer LM, Sarapas C, Makotkine I, Andrew R, Seckl JR.
Cortisol metabolic predictors of response to psychotherapy for
symptoms of PTSD in survivors of the World Trade Center attacks
on September 11, 2001. 2009; May 1 [Epub ahead of print].
6
Edinburgh Tommy’s Centre for Maternal and Fetal Health. Impact Factor Report
Journal Impact Factor Authors / Title
Human 3.773
Reproduction, Shaw JLV, Denison FC, Evans J, Durno K, Williams A, Entrican G
Jabbour HN, Critchley HOD, Horne AW. Evidence of prokineticin
dysregulation in Fallopian tube from women with ectopic
pregnancy. 2009 (in press).
Journal of 3.756
Chromatography Homer NZM, Reynolds RM, Mattsson C, Bailey MA, Walker BR,
Andrew R. Quantitative analysis of RU38486 (mifepristone) by
HPLC triple quadrupole mass spectrometry. 2009; 877(5-6):
497-501.
Neuropathology 3.660
Applied Neurobiology Lai M, Bae SE, Bell JE, Seckl JR, Macleod MR. Mineralocorticoid
receptor mRNA expression is increased in human hippocampus
following brief cerebral ischaemia. 2009; 35:156-64.
Molecular and 3.611
Cellular Endocrinology Kang P, Rogalska J, Walker CA, Burke M, Seckl JR, Macleod MR,
Lai M. Injury-induced mineralocorticoid receptor expression
involves differential promoter usage: A novel role for the rat
MR beta variant. 2009; 305: 56-62.
Molecular and 3.611
Cellular Endocrinology Sales KJ, Grant V, and Jabbour HN. Prostaglandin E2 and F2alpha
activate the FP receptor and up-regulate cyclooxygenase 2
expression via the cAMP response element. 2008; 285: 51-61.
Clinical and 3.556
Experimental Allergy de Vries A, Hazlewood L, Fitch PM, Seckl JR, Foster P, Howie SE.
High-fat feeding redirects cytokine responses and decreases
allergic airway eosinophilia. 2009; Jan 22. [Epub ahead of print].
American Journal 3.453
Obstetrics and Gynecology Bollapragada S, Youssef R, Jordan F, Greer IA, Norman JE,
Nelson S. Term labor is associated with a core inflammatory
response in human fetal membranes, myometrium, and cervix.
2009; 104.e1-11.
European Journal 3.385
of Neuroscience
Lucassen PJ, Bosch OJ, Jousma E, Krömer SA, Andrew R, Seckl JR,
Neumann ID. Prenatal stress reduces postnatal neurogenesis
in rats selectively bred for high, but not low, anxiety: possible
key role of placental 11β-hydroxysteroid dehydrogenase type 2.
2009; 29: 97-103.
Behavior Genetics 3.289
Simoncic, M, Horvat, S, Stevenson, PL, Holmes, MC, Bunger, L,
Kenyon, CJ, Speakman, JR, Morton, NM. Divergent physical
activity and novel alternate responses to high fat feeding in
polygenic Fat and Lean mice. 2008; 38(3):292-300.
British Medical 3.277
Bulletin Strachan MW, Reynolds RM, Frier BM, Mitchell RJ, Price JF. The
relationship between Type 2 Diabetes and dementia. 2008;
88(1):131-146.
Edinburgh Tommy’s Centre for Maternal and Fetal Health. Impact Factor Report
7
Journal BMC Medicine
Impact Factor Authors / Title
3.276
Huh SY, Andrew R, Rich-Edwards JW, Kleinman KP, Seckl
JR and Gillman MW. Association between umbilical cord
glucocorticoids and blood pressure at age 3 years. 2008; 6:25
doi:10.1186/1741-7015-6-25.
Analytica 3.146
Chimica Acta Pournamdari M, Saadi A, Ellis E, Andrew R, Walker BR, Watson DG.
Development of a derivatisation method for the analysis of
aldehyde modified amino acid residues in proteins by Fourier
transform mass spectrometry. 2009; 633: 216-222.
BJOG
3.101
Denison FC, Lynch J, Harper N, Reynolds RM. Increased Maternal
BMI is associated with an Increased Risk of Minor Complications
during Pregnancy. 2009; June 4 [Epub ahead of print].
BJOG
3.101
Bollapragada SS, MacKenzie F, Norrie JD, Eddama O, Petrou
S, Reid M, Norman JE. Randomised placebo controlled trial
of outpatient (at home) cervical ripening with isosorbide
mononitrate (IMN) prior to induction of labour clinical trial with
analyses of efficacy, cost effectiveness and acceptability. The
IMOP Study. 2009; 116:1185–1195.
BJOG
3.101
Eddama O, Petrou S, Schroeder L, Bollapragada SS, MacKenzie F,
Norrie J, Reid R, Norman JE. The cost-effectiveness of outpatient
(at home) cervical ripening with isosorbide mononitrate prior to
induction of labour. 2009; 116:1196-203.
Biomed Central 3.08
Cancer Collins F, MacPherson S, Brown P, Bombail V, Williams ARW,
Anderson RA, Jabbour HN and Saunders PTK. Expression of
oestrogen receptors, ERalpha, ERbeta and ERbeta variants, in
endometrial cancers and evidence that prostaglandin F may
play a role in regulating expression of ERalpha. 2009; (in press).
Reproduction
Reynolds RM, Logie JJ, Roseweir AK, McKnight AJ, Millar RP. A
role for kisspeptins in pregnancy: facts and speculations. 2009;
138 (1):1-7.
3.073
Journal of 2.913
Neuroendocrinology
Carter R, Paterson JM, Tworowska U, Stenvers DJ, Mullins JJ, Seckl
JR, Holmes MC. Hypothalamic-pituitary-adrenal axis
abnormalities in response to deletion of 11β-HSD1 is strain
dependent. 2009; Jul 7 [Epub ahead of print].
Journal of 2.897
Endocrinological Investigation Gambineri A, Forlani G, Munarini A, Tomassoni F, Cognigni GE,
Ciampaglia W, Pagotto U, Walker BR, Pasquali R. Increased
clearance of cortisol by 5β-reductase in a subgroup of women
with adrenal hyperandrogenism in polycystic ovary syndrome.
2009 ; 32 : 210-218.
8
Edinburgh Tommy’s Centre for Maternal and Fetal Health. Impact Factor Report
Journal Impact Factor Authors / Title
Journal of 2.791
Endocrinology O’Regan D, Kenyon CJ, Seckl JR, Holmes MC. Prenatal
dexamethasone ‘programmes’ hypotension, but stress-induced
hypertension in adult offspring. 2008;196(2):343-52.
Journal of 2.791
Endocrinology Ye P, Kenyon CJ, Mackenzie SM, Nichol K, Seckl JR, Fraser
R, Connell JM, Davies E. Effects of ACTH, dexamethasone, and
adrenalectomy on 11beta-hydroxylase (CYP11B1) and
aldosterone synthase (CYP11B2) gene expression in the rat
central nervous system. 2008; 196:305-11.
Journal of 2.791
Endocrinology
Livingstone DEW, Grassick SL, Currie GL, Walker BR, Andrew R.
Dysregulation of glucocorticoid metabolism in murine obesity:
comparable effects of leptin resistance and deficiency.
2009; 201 : 211-218.
Obesity
Goedecke JH, Levitt NS, Lambert EV, Utzschneider KM,
Faulenbach MV, Dave JA, West S, Victor H, Evans J, Olsson T,
Walker BR, Seckl JR, Kahn SE. Differential Effects of Abdominal
Adipose Tissue Distribution on Insulin Sensitivity in Black and
White South African Women. 2009; 17: 1506-1512.
2.762
Hormone and 2.715
Metabolic Research
Li RS, Nakagawa Y, Liu YJ, Fujisawa Y, Sai S, Nakanishi T, Chapman
KE, Seckl JR, Ohzeki T. Growth hormone inhibits the 11 betaHydroxysteroid dehydrogenase type 1 gene promoter activity
via insulin-like growth factor I in HepG2 cells. 2008; 40: 286-8.
European Journal 2.686
of Clinical Nutrition Forbes S, Robinson S, Parker KH, McCarthy MI, MacDonald IA and
Johnston DG. The thermic response to food is related to
sensitivity to adrenaline in a group at risk for the development
of Type 2 diabetes; 2009. 63: 1360-7.
Molecular Human 2.537
Reproduction Yuan M, Jordan F, McInnes I, Harnett MM, Norman JE. Leukocytes
are primed in peripheral blood in preparation for activation
during term and preterm labour. 2009 (in press).
QJM
2.483
Reynolds RM, Ilyas B, Price JF, Fowkes FGR, Newby DE, Webb DJ,
Walker BR. Circulating plasma cortisol levels are not associated
with coronary artery disease or peripheral vascular disease.
2009; 102 (7):469-475.
Leukemia
2.390
Research
Sai S, Nakagawa Y, Sakaguchi K, Okada S, Takahashi H, Hongo T,
Seckl JR, Chapman KE, Ohzeki T. Differential regulation of
11β-hydroxysteroid dehydrogenase-1 by dexamethasone in
glucocorticoid-sensitive and -resistant childhood lymphoblastic
leukemia. 2009; May 13 [Epub ahead of print].
Edinburgh Tommy’s Centre for Maternal and Fetal Health. Impact Factor Report
9
Journal Impact Factor Authors / Title
International 2.007
Journal of Clinical Practice Preiss D, Sattar N, L Harborne, Norman JE, Fleming, R. The effects
of 8 months of metformin on circulating GGT and ALT levels in
obese women with polycystic ovarian syndrome. 2008; 62: 1337.
Reproductive
1.951
Science
Challis JR , Lockwood CJ, Myatt L, Norman JE, Strauss JF, Petraglia
F. Inflammation and Pregnancy. 2009;16 206 – 215.
Reproductive 1.951
Science
Youssef RE, Ledingham MA, Bollapragada SS, O’Gorman N,
Jordan F, Young A, Norman JE. The role of Toll-Like Receptors
(TLR 2 & 4) and Triggering Receptor Expressed on Myeloid
Cells-1 (TREM-1) in human term and pre-term labour. 2009
(in press).
Reproductive
1.951
Science
Anderson L, Martin W, Higgins C, Nelson SM, Norman JE.
Inhibition of human myometrial contractility by progesterone
does not operate via potassium channels. 2009 (in press).
Applied Animal 1.823
Behaviour Science Jarvis S, Moinard C, Robson SK, Sumner BEH, Douglas AJ, Seckl
JR, Russell JA, Lawrence AB. Effects of weaning age on the
behavioural and neuroendocrine development of piglets.
2008; 110: 166-181.
Prenatal Diagnosis 1.596
Armstrong RA, Reynolds RM, Leask R, Shearing CH, Calder
AA, Riley SC. Decreased serum levels of kisspeptin in early
pregnancy are associated with intra-uterine growth restriction
and pre-eclampsia. 2009; July 6 [Epub ahead of print].
BMC Endocrine Disorders
Price JF, Reynolds RM, Mitchell R, Williamson R, Fowkes G, Deary
I, Lee A, Frier B, Hayes P, Strachan MWJ, on behalf of the ET2DS
Investigators. The Edinburgh Type 2 Diabetes Study: study
protocol. 2008; 8; 18.
Practical Diabetes International Price JF, Reynolds RM, Frier BM, Strachan MWJ. Type 2 diabetes
and cognitive impairment: the Edinburgh Type 2 Diabetes Study.
2008; 25(4).
1.2 Other publications: Book Chapters
Norman JE (2009) “Induction of labour” Chapter in: Clinical Obstetrics and Gynaecology. 2nd
Edition. Eds Magowan B, Owen P, Drife J. Saunders Elsevier. ISBN 978 0 7020 30697
Wyrwoll CS, Holmes MC and Seckl JR (2009). Early Life programming of affective function. In:
Understanding Depression, Pariante CM, Nesse RM, Nutt D and Wolpert L (eds), Oxford University
Press, Oxford, UK ISBN 978-0-19-953307-7 pp91-110.
Morton, NM (due to be published 2009). Glucocorticoids and inflammation in Obesity. Book
Chapter. Taylor and Francis Morton, NM.
Morton, NM (due to be published 2009).The Role of 11β-HSD1 in adipose inflammation in
obesity: Review: Molecular and Cellular Endocrinology
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Edinburgh Tommy’s Centre for Maternal and Fetal Health. Impact Factor Report
1.3 Patents
We have applied for a patenet for the use of lipoxins and resolvins as novel therapeutic agents
for treatment of preterm labour (MRC /Dr HN Jabbour, University of Edinburgh/Dr FC Dension
and Professor JE Norman).
1.4 Training
1.4.1 Postgraduate degrees awarded this year.
Hong Mu
Thesis title: Gender specific differences in programmed animal models.
Awarded Master of Medical Science
Amie Moyes (PhD)
Title of Thesis: Role of kinins in mediating vascular function in pre-eclampsia.
Supervisors Fiona Denison and Gillian Gray. Awarded Sept 2009
Amy Robb (MD)
Title of Thesis: Vascular biology in the menstrual cycle, pregnancy and pre-eclampsia
Supervisors: Fiona Denison and David Newby. Awarded October 2009.
1.4.2 Current PhD Students supervised by “Tommy’s” Principal Investigators.
Alison Wallace
Thesis title: FP receptor regulation of immune cell function. Submitted.
Sarah Barr
Title of Thesis: Origins and consequences of altered metabolic process in obese pregnant
women. On Programme.
Silvia Pedroni
Title of Thesis: Does inflammation mediate the adverse pregnancy outcomes observed in obese
pregnant women? On Programme.
Rachel Dakin
Title of Thesis: Programming of cardiovascular disease risk by maternal obesity. On Programme.
Lincoln Liu
Title of Thesis: Mechanisms underlying early life programming effects. On Programme.
Kate Hughes
Title of Thesis: 11β-Hydroxysteroid dehydrogenase type 1 and 5-alpha reductase: modulators of
intra-cellular glucocorticoid action. On Programme.
Nor Mohd Shukri
Title of Thesis: Energy Balance in Obesity associated pregnancy. On Programme.
James O’Reilly
Title of Thesis: Epigenetic modification in the early life programming of disease: impact of
maternal nutritional status. On Programme.
Edinburgh Tommy’s Centre for Maternal and Fetal Health. Impact Factor Report
11
Sharon Eddie
Thesis title: Local mediators of human germ cell development. On Programme.
Jackie Maybin
Thesis title: Endometrial repair and regeneration. On Programme .
Jason Sutherland
Thesis title: The effect of seminal plasma prostaglandins on cervical cancer tumourigenesis. On
Programme.
Margaret Keightley
Thesis title: Prostaglandin receptor regulation of vascular function in reproductive tract cancers.
On Programme.
Aron Abera
Thesis title: Cyclooxygenase and prostanoid receptor expression and signalling in endometrium
of women with fibroids. On Programme.
Andreas Alber
Thesis title: Role of HIF-1 and EGFR in hyperoxic pulmonary endothelial injury. On Programme.
Sara Rinaldi
Thesis title: Role of lipoxin in inflammatory pathways in the human placenta. On Programme.
Omaima Idriss
Thesis title: Regulation of Adrenomedullin expression by PGF2alpha-FP receptor. On Programme.
Shalini Rajagopal
Thesis title: Lipoxins and resolvins: Novel suppressors of inflammation in cancer. On Programme.
Tijana Mitic
The role of murine 11B-Hydroxysteroid Dehydrogenase Type 1 (11BHSD1) in the metabolism of
7-oxysteroids. On Programme.
Sarah McSweeney
Inhibition of local glucocorticoid regeneration prevents deterioration of heart function post-MI
and enhances inflammation and angiogenesis during infarct healing. On Programme.
Lucinda Low
The Influence of Glucocorticoids in Vascular Lesion Development. On Programme.
Mark Nixon
Links between glucocorticoids, inflammation and obesity. On Programme.
Emma DiRollo
Role of 5alpha-reductase 1 in modifying anxiety and appetite. On Programme.
David MacFarlane
The role of fatty acid metabolism in the pathogenesis of non-alcoholic fatty liver disease. On
Programme.
Fraser Gibb
The role of aromatase in determining insulin sensitivity and body fat distribution. On
Programme.
12
Edinburgh Tommy’s Centre for Maternal and Fetal Health. Impact Factor Report
Javaid Iqbal
Effect of corticosteroid metabolism on atherosclerosis and post angioplasty restenosis. On
Programme.
Kate Hughes
11β-Hydroxysteroid dehydrogenase type 1 and 5-alpha reductase: modulators of intra-cellular
glucocorticoid action’ . On Programme.
Rachel Dakin
Programming of cardiovascular disease risk by maternal obesity. On Programme.
Lincoln Liu
Mechanisms underlying early life programming effects. On Programme.
Mathew Harris
Masters student (BBSRC 4 year PhD programme). On Programme.
Kathryn Wilson
Masters student (BHF 4 year PhD programme). On Programme.
In addition to these PhD students, the investigators supervisor the research project of a large
number of masters students via the MSc in Reproductive Biology.
1.5 Invited and plenary lectures; International and National Conferences
Attended and Awards
1.5.1 Plenary and Invited lectures
Professor Jane Norman
‘Understanding and preventing preterm labour’ at the Italian Consultant Obstetrician’s meeting.
Bergamo, November 2008.
‘Obesity – setting the scene’ at the Scottish Obstetrician and Gynaecologists Consultants’
Conference, Dunkeld, December 2008.
‘Inflammatory pathways in the mechanism of parturition’ at “Fertility 2009”, Edinburgh (Joint
meeting between the British Fertility Society, Society for Reproduction and Fertility and the
Association of Clinical Embryologists) January 2009.
‘The Inflammatory Events of Parturition – Are They All In The Uterus? (and how does this help
us prevent preterm labour)’? at the Myometrial satellite meeting of the Society for Gynecologic
Investigation meeting, Glasgow, March 2009.
‘Born too soon: causes, consequences and dealing with premature babies’ at the Centre for
Reproductive Biology, QMRI, Edinburgh, March 2009.
‘The maternal and fetal effects of obesity in pregnancy – links to inflammation and insulin
resistance’ for the Cardiovascular Seminar Series, QMRI, Edinburgh, May 2009.
‘Obesity now – what you need to know’ at the Royal College of Physicians of Edinburgh,
May 2009.
‘Improving birth in the 21st century’ at the Royal College of Obstetricians and Gynaecologists,
June 2009.
Edinburgh Tommy’s Centre for Maternal and Fetal Health. Impact Factor Report
13
‘Preterm labour’ at the Aurelija Dubicke thesis viva symposium, Stockholm, June 2009.
‘Clinical aspects of obesity in pregnancy and labour’ at the University of Newcastle, Australia,
August 2009.
‘Progesterone for prevention of preterm labour at the University of Newcastle, Australia, August
2009.
‘Mechanisms by which obesity causes adverse pregnancy outcome’ at the University of
Newcastle, Australia, August 2009.
‘The Right Time to Induce: Predictive Tools’ for the “in Induction of labour” at FIGO, Cape town,
South Africa, October 2009.
‘Delivery of the preterm fetus’. In ‘Preterm delivery’ at FIGO, Cape Town, South Africa, October
2009.
‘Paediatric outcomes in Obstetric Trials’ at the 50th Annual Meeting of the European Society for
Paediatric Research ESPR, Hamburg, October 2009.
‘Predicting and preventing preterm birth’ at the RCOG Senior Staff Conference, November 2009.
“Increasing rates of preterm birth in the UK: aetiology and treatment” Honeyman Gillespie
lecture, Edinburgh, November 2009.
Dr Fiona Denison
‘Impact of Obesity on maternal reproductive fitness’ at the Society for Reproduction and Fertility
Conference, July 2009.
‘Role of kinins in mediating Vascular and fibrinolytic function in pre-eclampsia’ at Manchester
University, March 2009.
Dr Mandy Drake
‘The Intergenerational Consequences of Fetal Programming’. at the British Endocrine Societies
Meeting, Harrogate, March 2009
‘Who’s in control? How hormones rule our lives from start to finish’ at the MRC Human
Reproductive Sciences Unit, Edinburgh, December 2009.
Dr Rebecca Reynolds
Long-term consequences for adult health, Simpson Symposium, Edinburgh, August 2008.
‘Maternal influences on fetal programming of the HPA axis’ Tommy’s Centre Meeting,
Manchester 2008.
‘Long-term consequences of Early Life Stress’ at the Long-term consequences of early life stress
symposium, Israel, 2008.
‘Obesity in Pregnancy –the Physician’s view’ Medical Disorders in Pregnancy meeting,
Edinburgh 2009.
‘Top 10 tips for managing co-morbidities in diabetes’ BMJ Masterclass in Diabetes, Glasgow,
2009.
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Edinburgh Tommy’s Centre for Maternal and Fetal Health. Impact Factor Report
Professor Jonathan Seckl
‘Steroids, enzymes and cognitive ageing: more than a one-trick pony’ at the University of
Toronoto, Toronto, April 2009.
‘Glucocorticoid metabolism in psychoneuroendocrinology: red hot or red herring’ at the
International Society of Psychoneuroendocrinology (ISPNE) meeting, San Francisco, July 2009.
Professor Brian Walker
‘Glucocorticoids and cardiovascular disease’ at the Glasgow BHF Cardiovascular Research Centre,
Glasgow.
‘Translational Medicine – venturing out of the academic bunker’ at the 2nd Synergy in Human
and Animal Research Symposium, University of Copenhagen.
‘Glucocorticoids and glucose intolerance’ at the Merck Expert Input Forum on Selective
Glucocorticoid Receptor Modulators, Philadelphia, USA.
‘Laying the runway for 11β-HSD1 inhibitors’ for the Translational Medicine Research Centre
Seminar series, Dundee, UK.
‘Glucocorticoids and Cardiovascular Disease’ at the Diabetes Association and Endocrinology
Society of Republic of China Annual meeting, Tapei, Taiwan.
‘11β-HSD1 inhibition: reaping what’s been sown in academic drug discovery’ at the UK Drug
Discovery Consortium Symposium, London, UK.
‘A researcher’s perspective on the patient’s journey: arrivals, departures, delays and diversions’
at the Lothian Diabetes Managed Clinical Network Professional Conference, Edinburgh.
‘Glucocorticoids and cardiovascular disease’ at the Roslin Institute, Edinburgh.
Dr Shareen Forbes
‘The management of Non-alcoholic fatty liver disease.’ Merck and Co. Lecture to General
Practitioners, October 2009.
‘Complications of obesity in pregnancy and Labour’ for the MSc in Clinical Nutrition Course.
University of Surrey. July 2009.
‘Non-alcoholic fatty liver disease and its relationship to Type 2 diabetes’ at the Diabetes UK
Clinical Networking day, London, November 2008.
‘Management of Non Alcoholic fatty liver disease’ at the Queen Margaret University, Life is Sweet
(Diabetes) Conference. October 2008.
Professor Henry Jabbour
‘Inflammatory pathways in endometrial cancer’. at the Society for Reproductive Biology.Adelaide,
Australia.
‘Inflammatory pathways in endometrial health and disease’. at the Horizon in Biomedicine Series:
The Next Big Thing in Women’s Health, Glasgow.
‘Prokineticins: Novel regulators of reproductive function’. at the 4th Society for Gynaecological
Investigation (SGI) endometrial satellite symposium held in Glasgow.
Edinburgh Tommy’s Centre for Maternal and Fetal Health. Impact Factor Report
15
‘Local communication in the uterus during implantation’ at the Annual Conference of the British
Fertility Society held in Liverpool .
‘GPCR signalling in health and disease’ at the Annual Conference of the Society for Reproduction
and Fertility held in Edinburgh.
‘Prokineticins: are they novel regulators of implantation and placental function? at the World
Congress in Reproductive Biology held in Hawaii.
‘Prokineticins in reproductive health and disease’ at the Monash Institute of Medical Research,
Melbourne, Australia.
‘Prokineticin function in reproductive health and disease’ at The University of Adelaide, Adelaide,
Australia.
‘Lipid signalling in reproductive health and disease’.at the Centre for Cardiovascular Science,
Edinburgh.
‘Targeting inflammatory signals in female reproductive pathology’. at the Royal Veterinary
College, London.
‘Periods: a bleeding pain’at the Centre for Reproductive Biology series of public lectures,
Edinburgh
Dr Nik Morton
Presented for the Young Endocrinologist Basic Prize Lecture (British Endocrine Society)
Harrogate, 2008
1.5.2 Awards to trainees / postdoctoral fellows
Kate Hughes and James Logie each won a prize for their poster presentations at the British
Endocrine Societies (BES) in Harrogate, March 2009
1.6 Other Notable Contributions from the Edinburgh Tommy’s group
Our senior staff continue to make valuable contributions to the national and international
research society. In particular this year, Henry Jabbour was awarded an Honorary Professorship
from the University of Edinburgh and Professor Jane Norman was awarded the SGI President’s
Achievement award for 2009
1.6.1 Book Editorships
l Professor Brian Walker is editor of: Davidson’s Principles and Practice of Medicine
l Professor Jane Norman - editor of: Book of the proceedings of the RCOG study group on
Maternal and Infant Deaths: Chasing Millennium Development Goals 4 and 5 to be published
in 2010
1.6.2 Editorial Board Membership
l Professor Brian Walker – Editorial Board member of Endocrinology
l Professor Brian Walker – Editorial Board member of the Journal of Molecular Endocrinology
l Professor Brian Walker – Editorial Board member of Neuroendocrinology
l Professor Jane Norman - is a member of the Writing panel for the UK confidential enquiry on
maternal and child health report “Saving mother’s lives” 2006 – 2008, to be published in 2010.
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Edinburgh Tommy’s Centre for Maternal and Fetal Health. Impact Factor Report
l Dr Rebecca Reynolds – invited to join the Editorial Board of Journal of Developmental Origins
of Health and Disease 2009
l Dr Rebecca Reynolds – invited to join Editorial Board of Neuroendocrinology 2009
l Professor Jonathan Seckl - Editorial Board member of Endocrinology (US)
l Professor Jonathan Seckl - Editorial Board member of Steroids (US)
l Professor Jonathan Seckl - Editorial Board member of Stress
l Professor Jonathan Seckl - Editorial Board member of Epigenetics (US)
l Professor Henry Jabbour - Editorial Board member of Molecular and Cellular Endocrinology
l Professor Henry Jabbour - Editorial Board member of Journal of Clinical Endocrinology and
Metabolism
l Professor Henry Jabbour - Editorial Board member of Reproduction
l Professor Henry Jabbour - Editorial Board member of Journal of Endocrinology
l Professor Henry Jabbour - Guest Editor for a focus issue on “vascular function in the
reproductive tract” to be published by Reproduction in 2010.
l Professor Henry Jabbour - Co-guest editor with Professor PTK Saunders for a special issue on
“Endo-immunology” to be published by Molecular and Cellular Endocrinology in 2010.
l Professor Jane Norman - Guest editor for the journal Reproduction, for an issue devoted to
“Obesity” to appear in 2010
1.6.3 Memberships of other relevant scientific committees
l Professor Jane Norman is a member of the Data Monitoring Committee, INFANT study
[Intelligent Fetal Monitoring and Assessment] HTA funded.
l Professor Jane Norman is the Chair for the Trial Steering Committee, I2S2 study [A
randomised controlled trial of iodide supplementation in preterm infants] MRC funded
l Professor Jane Norman is the Chair for the Steering Group, Women and Children’s Health
Information Programme, NHS Scotland
l Professor Jane Norman is a member of the Clinical Study Group in Preterm Birth, RCOG
l Professor Jane Norman is the Chair for The maternal and perinatal health research and
epidemiology advisory group (MAPREG) at the World Health Organisation.
l Professor Jane Norman was a member of the Scientific Organising Committee, Society of
Gynecologic Investigation Annual Meeting, Glasgow 2009
l Professor Jane Norman is a member of the Action Medical Research Charity, grant awarding
committee (term ends autumn 2009)
l Professor Jane Norman is a member of the Efficacy and mechanisms evaluation board (NIHR
MRC collaboration)
1.7 Recent Media – Radio, Television, online and Newspaper interviews
l Dr Fiona Denison - Blast Films, ‘Obesity and pregnancy’
l Professor Jane Norman – Radio 4: Woman’s hour
Edinburgh Tommy’s Centre for Maternal and Fetal Health. Impact Factor Report
17
l Professor Jane Norman – BBC Radio Scotland: Good morning Scotland
l Professor Jane Norman - Radio Forth, Edinburgh
l Professor Jane Norman - Radio 4 programme “A moment too soon” Broadcast June 2009
l Professor Jane Norman - Evening Times,
l Professor Jane Norman - BBC news website
l Dr Rebecca Reynolds - Radio interview for Radio Scotland Dec 08: ‘Obesity in pregnancy’
l Dr Rebecca Reynolds - Press release May 09 following publication of paper in Hypertension.
Articles on University of Edinburgh Web page, the Scotsman, the Evening News, the Daily
Mail and the Times
l Dr Rebecca Reynolds - Press release July 09 following publication of paper in BJOG. TV
interview for STV, radio interview for Forth FM and Borders Radio, articles in Scotsman and on
University of Edinburgh Web page
l Dr Shareen Forbes – Press release for aquanatal class, The Scotsman, February 2009
l Dr Shareen Forbes – Radio Scotland, Tommy’s Clinic at the University of Edinburgh, March
2009
l Dr Shareen Forbes - Diabetes UK Patient’s Forum, October 2008. Radio interview for Radio
Scotland ‘Obesity in Pregnancy’
l Professor Jane Norman –
n Yorkshire Post, 22 September 2009 (Preterm Babies paper)
n Daily Mail, 22 September 2009 (Preterm Babies paper)
n Express, 22 September 2009 (Preterm Babies paper)
n Times, 22 September 2009 (Preterm Babies paper)
n Courier and Advertiser, 22 September 2009 (Preterm Babies paper)
n Daily Mirror, 22 September 2009 (Preterm Babies paper)
n Herald, 22 September 2009 (Preterm Babies paper)
n Press and Journal, 22 September 2009 (Preterm Babies paper)
n The Scotsman, 22 September 2009 (Preterm Babies paper)
n The Sun, 22 September 2009 (Preterm Babies paper)
n Scottish Television, 22 September 2009 (Preterm Babies paper)
n Forth AM, 22 September 2009 (Preterm Babies paper)
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Edinburgh Tommy’s Centre for Maternal and Fetal Health. Impact Factor Report
1.8 Edinburgh Tommy’s Centre Research Funding 2009
The principal investigators at the Edinburgh Tommy’s Centre have the following grant funding in
addition to core support from Tommys.
Title and Applicants
Duration of Award
Amount
Mullins JJ, Fox KAA, Girkin J, Harmar AJ, McRae CA,
Newby DE, Savill JS, Seckl JR, Walker BR, Webb DJ,
Wilmut I. British Heart Foundation Centre of
Excellence Award.
2008-2014
£7,600,000
Iredale JP, Walker BR for College of Medicine &
Veterinary Medicine, University of Edinburgh,
Wellcome Trust. PhD Programme for Clinicians.
2008-2016
£5,000,000
Walker BR, Seckl JR, Webster SP. 11β-HSD1 inhibition –
tissue specific control of cortisol action. Wellcome Trust
Seeding Drug Discovery award.
2008-2011
£4,996,470
2006-
£4,198,368
Stulnig T, Schroder M, Zechner R, Bruning J, Staels B,
Cinti S, Walker B. TOBI – Targeting Obesity Driven
Inflammation. European Union Framework 7 Collaborative Project.
2008-2011
(€339,156 to Edin)
€2,980,964
Scottish Translational Medicine and Therapeutics
Initiative. Webb DJ, McInnes I for the four Scottish
Medical Schools (BR Walker lead for MSc education
and for Metabolic Disease research). Wellcome Trust
training initiative.
2008-2011
£2,750,000
Norman JE et al , MRC awarded. Does progesterone
prophylaxis to prevent preterm labour improve
outcome- a randomised double blind placebo
controlled trial? (OPPTIMUM). Dec 2007 –2012 £2,700,000
2004-2009
£2,074,728
2009-10
£2,000,000
Profs JR Seckl, Newby DE, Haslett C, Bastin M, Critchley H,
Deary I, Fox K, Johnstone E, Walker BR, Wardlaw J, Wilmut I.
Clinical Research Infrastructure Fund. Clinical Research
Imaging Centre, University of Edinburgh.
Fox KAA, Webb DJ, Mullins JJ, Seckl JR, Walker BR,
McDicken N, Marshall I, Newby DE. BHF Imaging Facility,
British Heart Foundation Cardiovascular Research Initiative.
Seckl J, with Profs Savill, Auer and Dr Marriage,
Medical Research Council. Pilot Developmental
Pathway Funding Scheme Portfolio .
Edinburgh Tommy’s Centre for Maternal and Fetal Health. Impact Factor Report
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Seckl JR, Mullins JJ, Savill JS, Walker BR, Chapman KE.
11β-Hydroxysteroid dehydrogenase type 1 and
atherosclerosis risk. Wellcome Trust Programme Grant
(3rd extension).
2007-2012 £1,529,245
2006-09 $1,350,000
Walker BR with Andrew R, Reynolds RM, Seckl JR,
Jansen M, Watson D, Critchley H. Defining the pathway
of biomarkers for pharmacodynamics, efficacy and
toxicity for 11β-HSD1 inhibition in metabolic disease
indications. Translational Medicine Research Institute.
2007-2010
£1,298,397
Norman JE, Denison FC, Drake AJ, Forbes S, Reynolds R,
Walker B, Newby DE, Murray G, Wray S, Quenby S.
Does Metformin reduce excess birthweight in offspring
of obese pregnant women. A randomised controlled trial of efficacy, exploration if mechanisms and evaluation of other pregnancy complications? NIHR. Efficacy and Mechanism Evaluation Programme. Awarded
October 2009,
grant tenure
Feb 2010 – Jan 2014.
£990,000
Seckl JR, Medical Research Council. Dissecting
epigenetic mechanism for the transgenerational
inheritance of glucocorticoid programming.
(MRC Clinician Scientist Award for Dr A Drake)
2006-10
£970,822
Profs Seckl JR, M Walkinshaw, Bird A and Barlow P,
Wellcome Trust. Protein factory facility funding.
2007-12
£944,432
Walker BR, Andrew R. Tissue-specific disruption of
glucocorticoid signalling: new mechanisms and
therapies for cardiovascular risk. British Heart
Foundation Programme Grant (extension).
2006-2011
£808,824
Fox KAA, Mullins JJ, Seckl JR, Walker BR, Webb DJ.
Provides 11 studentships for 4-year PhD training.
(British Heart Foundation 4-year PhD
studentship programme).
2004-2010
J Seckl, Profs M Meaney, M Szyf, ER de Kloet and
M Joels), Human Frontiers Science Program.
The mechanisms of early life programming?
Seckl JR, Medical Research Council. Glucocorticoids
and foetal programming of adult hyperglycaemia:
dissecting the fundamental molecular mechanisms.
MRC Clinician Scientist Award for Dr M Nyirenda.
20
2006-10
£800,000
£751,576
Edinburgh Tommy’s Centre for Maternal and Fetal Health. Impact Factor Report
Title and Applicants
Calder AA, Norman JE et al Piggy Bank Kids for
Jennifer Brown Research Laboratory. Duration of Award
April 2008 – March 2011
Amount
£750,000
Seckl JR, Yau J. 11ß-hydroxysteroid
dehydrogenase type 1 and cognitive ageing. MRC.
2006-10 £621,868
Seckl JR, Chapman K [PI], Savill J and Gray M,
Medical Research Council. How does 11B-hydroxylated
dehydrogenase type I limit inflammation?
2008-11
£487,000
Seckl JR, Holmes M, Paterson J, Mullins J,
Wellcome Trust. Prenatal programming of anxiety
behaviour by glucocorticoids: a function of 11ß-HSD2
in brain or placenta or both? 2006-10
Price JF, Reynolds RM, Strachan MWJ, Deary I,
Frier BM, Fowkes FGR, Lee AJ, Medical Research Council.
Inflammation, glucocorticoids and microvascular disease
in the aetiology of cognitive impairment in type 2 diabetes.
Seckl JR, Wellcome Trust. Investigating genetic leanness:
what goes ‘right’ in obesity-resistance. (Research Career
Development Fellowship for Dr NM Morton).
Andrew R, Walker BR, Stewart LH. Do 5β-reductase
inhibitors predispose patients to the metabolic syndrome?
Chief Scientist’s Office, Scottish Government Project Grant. 2006-2011
2006-10
£462,653
£444,312
£434,900
2009-2012
£431,511
2008-12
£399,686
Strachan MWJ, Reynolds RM, Price JF, Frier BM, Hayes PC.
Pfizer Pharmaceuticals. Early detection and risk factors for
progression of non-alcoholic fatty liver disease in people
with type 2 diabetes: a prospective study. 2007-2010
£348,000
Seckl JR with Savill J, Medical Research Council. Pilot study
of a translational entrepreneur in medical research.
2007-10
£273,732
Gibb FW with Andrew R and Walker BR. Intra-adipose
generation of oestrogens in humans: implications for
body fat distribution and the metabolic complications
of obesity. Wellcome Trust Clinical Training Fellowship.
2007-2010
£248,088
Seckl JR, Jamieson PM, Chen A, Wellcome Trust.
Urocortin 3 and the corticotropin releasing factor type 2
receptor: role in HPA axis functions and stress-related
behaviours in transgenic mouse models.
2007-10
£244,614
Seckl JR with De Kloet ER, Olsson T, de Quervain D,
MRC/ESF. Programming of hippocampal GR: MR balance
and stress responses across the lifespan. Edinburgh Tommy’s Centre for Maternal and Fetal Health. Impact Factor Report
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Title and Applicants
McInnes KJ with Walker BR and Andrew R. The role of
androgens in adipose tissue in the development of
diabetes. Diabetes UK RD Lawrence Fellowship.
Denison FC, Jabbour HN. MRC Career Development
Post-Doctoral Fellowship for Dr Jennifer Waddell.
Seckl J, Walker BR, Hadoke PWF, British Heart
Foundation. 11ß-Hydroxysteroid dehydrogenases and
vascular remodelling after tissue injury. Duration of Award
Amount
2008-2011
£157,316
Nov 2006 - Oct 2009
£155,000
2006-09
£145,808
Jabbour H, Catalano R, Norman JE, Dension FC, Brooker R.
Screening efficacy of PROKR1 antagonists in the treatment
of pre-term labour. MRC Development Gap Funding.
July 2009 – June 2011
£143,876
Macfarlane DP with Walker BR and Iredale JP.
Determinants of progression of non-alcoholic fatty
liver disease. Wellcome Trust Clinical Training Fellowship.
2007-2009
£142,478
Horne A, Jabbour HN, Entrican G and Critchley HOD.
Aberrant prokineticin expression as a cause for ectopic
pregnancy: the effects of chlamydia trachomatis infection
and smoking. WellBeing of Women.
2008-2010
£128,445
Norman JE, Harnett M, McInnes I, Nelson S, Martin W.
The functional role of Toll like receptor activation in
parturition – potential targets for the prevention of
preterm birth. Action Medical Research. November 07 – October 09 £120,774
Andrew R, Kenyon CJ, Rossi AG, Walker BR. Dissociating
anti-inflammatory and diabetogenic effects of
glucocorticoids by manipulating their 5β-reduction.
Diabetes UK Project Grant.
2005-2009
£110,529
Reynolds RM, Drake AJ, Seckl JR, Godfrey KM, Cooper CC.
Chief Scientist Office, Scotland Epigenetic modification of
glucocorticoid receptors by early life events.
2007-2008
£103,532
RCUK fellowship (Dr Nik Morton) Systems Biology.
Approaches to Adipose Mechanisms in Obesity and
Obesity Resistance.
2008 -2011
£83,500
Hirani N and Jabbour HN. MRC-British Lung Foundation
capacity building studentship for Andreas Alber. Role of
HIF-1 and EGFR in hyperoxic pulmonary endothelial injury.
2009-2013
£80,657
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Edinburgh Tommy’s Centre for Maternal and Fetal Health. Impact Factor Report
Title and Applicants
Duration of Award
Amount
Reynolds RM. Sir Jules Thorn PhD Scholarship Programme
2009. Epigenetic modification in the early life programming
of disease: impact of maternal nutritional status. 2009-2012
£78,850
McSweeney S with Gray GA, Walker BR, Hadoke PWF.
11β-Hydroxysteroid dehydrogenase type 1 – a new
therapeutic target post- myocardial infarction? Hypertension
Research Trust PhD Studentship.
2006-2009
£60,255
Drake M, Forbes S, Reynolds RM, Norman JE,
Denison FC, Menon G, Laing I. Diabetes UK. Equipment
Grant for a PEA-POD for measuring neonatal body
composition.
April 2009
£60,000
Nixon M with Andrew R, Walker BR, Rossi A. 5β-Reductase
modulation of inflammatory disease. University of
Edinburgh PhD Scholarship.
2007-2010
£52,524
Anderson RA and Jabbour HN. PhD studentship from the
College Scholarship Fund awarded to Ms Sharon Eddie on
Local mediators of human germ cell development.
2008-2011
£42,720
Bhattacharya S, Bhattacharya S, Lee A, Norman JE,
Campbell D, Ruiz-Mirazo E. Inherited predisposition to
spontaneous preterm birth. March of Dimes foundation.
2008-9 dollars £86,893
Reynolds RM, Andrew R and colleagues in Endocrinology
Principal’s E-learning fund (University of Edinburgh).
The Virtual Hospital. Development of Case-Based
Educational Scenarios.
2007-2009
£40,000
Forbes S et al. University of Edinburgh Clinical Research
Facility Grant received for BOD-POD for measuring
infant/adolescent and adult body composition.
July 2009
£30,000
Stimson RH with Walker BR. Dissection of pathways by
which glucocorticoids interact with other hormones
to regulate energy metabolism. Academy of Medical
Sciences/Wellcome Trust start-up grant for Clinical Lecturers.
2009-2011
£29,600
Strachan MWJ, Reynolds RM, Price JF, Hayes PC,
BM Frier, Chief Scientist Office, Scotland. Epidemiology of
abnormal liver function in adults with Type 2 diabetes:
a prospective, population-based study.
2006-2009
£23,128
Denison FC, S Forbes et al. Establishment of panlothian
aquanatal exercise classes for obese pregnant women –
a multidisciplinary Partnership approach. Bruntsfield
Endowment Fund. Edinburgh Tommy’s Centre for Maternal and Fetal Health. Impact Factor Report
£12,100
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Title and Applicants
Duration of Award
Amount
Ferguson EF, Norman JE, Chalmers J, Shanks E,
Finlayson A. Investigation of the beneficial and adverse
effects of induction of labour. Chief Scientist’s Office,
Scottish Executive.
Jan 2009 – Dec 2009 £10,651
Royal Society International Incoming Short Visit grant
2008/R2 awarded to HN Jabbour and A Katz. The grant
was awarded to conduct collaborative research on role
of PGE2 and seminal plasma PGE2 in cervical cancer.
2009
£4,782
Denison FC. Maternal obesity and its affect on placental
and uterine function. University of Edinburgh Alumni
for consumables.
2008 – 2009
£2,500
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Edinburgh Tommy’s Centre for Maternal and Fetal Health. Impact Factor Report
The Edinburgh
Tommy’s Centre for
Maternal and Fetal Health
Centre for Reproductive Biology
University of Edinburgh
www.tommys.org
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