THE COLLABORATION BETWEEN PLASTIC SURGEONS AND SKIN CARE THERAPISTS Dr. Desmond Fernandes, Plastic Surgeon, Cape Town, South Africa Modern scientific skin care has created the need for greater collaboration between skin care therapists and plastic, reconstructive and aesthetic surgeons. The surgeon generally does not have the time or patience to be involved in working out a good skin care routine for his patients even though this will make an important contribution towards the final result. This is where skin care therapists can use their expertise to make sure that scars heal better and the skin has a radiant healthy youthful character. But of course the therapist must first understand how to influence skin and make it healthier and set the stage for the skin to heal as well as possible. Unfortunately, many therapists are not sufficiently educated in skin physiology, so I will give a brief outline of the physiology underlying the growing and healing process of skin. When a surgeon operates on skin, he needs the skin to: 1. Be as healthy as possible 2. Heal as rapidly as possible 3. Heal with minimal post-traumatic hyperpigmentation No matter where the operation is to be, the skin can be prepared for the operation by a knowledgeable therapist. MAKING HEALTHY SKIN Without doubt the most important nutrient for healthy skin is vitamin A. Most of us walk around with varying degrees of deficiency of vitamin A in our skin because it is easily destroyed by exposure to light. The major form of vitamin A in the skin is retinyl palmitate and this is the most sun-susceptible version of the retinoids. Because this is the version of vitamin A that is destroyed by the sun, I believe this exact molecule should be replaced by daily skin care. Retinyl palmitate is converted continuously to retinol, and then to retinyl aldehyde and finally to the various isomers (variations) of retinoic acid. Retinoic acid controls the normal activity of cells through its effects on the DNA. It directs the keratinocytes, those important basal cells of the epidermis, to grow to normal size, with a healthy metabolism. Vitamin A speeds up the rate of growth of keratinocytes and, as a result, wounds heal faster. Healthier collagen is produced, and in combination with vitamin C, scars will heal better and stronger. Vitamin C is also damaged by exposure to light and is used up in fighting free radicals induced by UV light. For that reason we also need to restore the normal balance of vitamin C in the area of the operation. The addition of other free radical scavengers, particularly vitamin E, and beta carotene will boost the antioxidant status of the skin and preserve more vitamin A and C in the skin. Both vitamin A and C act on the production of melanin. Vitamin C is a tyrosinase inhibitor and also provides an antioxidant rich milieu in the cell that acts against the production of melanin. Vitamin A also controls the production of melanin and tends to even out the distribution of melanin in the skin as well as reduce the total 1 melanin. For that reason both vitamin A and C needs to be in high levels to reduce the chances of post-inflammatory hyperpigmentation. Added antioxidants means that the vitamin C will be able to function better to control pigmentation. HOW TO PREPARE THE SKIN Most surgeons believe that only retinoic acid can be successfully used on skin. They also believe that the primary function of retinoic acid is as a peeling agent. They mistakenly believe that since retinoic acid is the actual functional form of vitamin A, that it should be used for skin care. Unfortunately, retinoic acid irritates skin and most patients will not use it as regularly as they should. Patients get a retinoid reaction in the beginning because they do not have sufficient retinoid receptors on the cell walls and cannot absorb the retinoic acid as fast as they should. Retinoic acid is an irritant to cell walls and that is one reason for the peeling effect. The outermost layers of the stratum corneum also flake off. The skin becomes pink and sensitive and it looks very much like the patient is allergic to retinoic acid. However, contrary to a true allergy, the longer one uses the retinoic acid, the less irritated the skin becomes because vitamin A stimulates the production of retinoid receptors and retinoic acid is metabolised properly. The important point is that the cell cannot handle all the retinoic acid and as a result the stores of vitamin A as retinyl palmitate build up and that eventually is responsible for the continuous increased supply of retinoic acid at physiological doses. I believe that we should apply retinyl palmitate or some other ester form of vitamin A (e.g. retinyl acetate or propionate), which is significantly less irritating and will produce the same results because it works better with the physiology of the skin. The dose of vitamin A should be as high as the patient can tolerate (up to about 10 to 50,000 i.u.g%) Right now there is a marketing fashion to use retinol which is also an irritant, but less so than retinoic acid. The fact is that virtually all the retinol will be converted to retinyl palmitate! So use retinyl palmitate right from the beginning. The retinyl palmitate molecule carries the energy that is required for the production of the various isomers of retinoic acid. The main advantage is that the client will use this product regularly and prime up the skin easily before the operation. Vitamin C can be used either as the ascorbic acid form or a stabilised form (e.g. Sodium or Magnesium ascorbyl phosphate.). The ascorbic acid can cause peeling of the skin due to its acid activity, so should be used with caution in clients with sensitive skin. Ascorbic acid is not stable and should preferably be used as a freshly made gel or solution. If the solution has turned brown then the ascorbic acid is no longer worth using. The ascorbyl phosphates are more neutral and can safely be used on sensitive skin. Their drawback is that they are rather expensive. From a practical point of view, ascorbic acid is generally used only on the face. You should advise the client also to take oral vitamin C. I prefer that they use about 1000 mg per day. Make sure that when using vitamin A and C that they are protected by their normal accompanying antioxidants, vitamin E and beta-carotene. These four vital nutrients act in concert with each other and should always be used together. 2 HOW TO FIND THE RIGHT PRODUCT FOR YOUR CLIENT The product containing vitamin A and C, E and beta-carotene should come either in a compressible aluminium foiled tube, thick oil or in an airless dispenser. If the product is supplied from the manufacturer in a typical cosmetic jar then the antioxidants and vitamin A will be destroyed by exposure to light and air and rendered useless. Make sure that the product is as fresh as possible to get the most activity out of these unstable vitamins. TREAT THE AREA OF THE PROPOSED SCAR The minimum preparation period should be about three weeks. The area where the scars are to be made must be treated at least twice a day. 1. For facelifts, then take care that the client should rub the preparation on the skin in front of, and behind, the ear. 2. For augmentation mammaplasty, then apply the cream either into the armpit or around the nipple or in the breast crease, according to the surgeon’s operative plans. 3. Reduction mammaplasty and abdominoplasty will also heal faster and the scars will be better if the whole breast or abdomen is treated pre-operatively for a protracted period. So if you know that your client wishes to have an operation like this, suggest that he/she prepares the skin for as long as possible. In combination with a lactate containing product, you will also get tightening of the skin that will help to create a more aesthetic result. 4. People with stretch marks will require intensive treatment with both vitamin A and C in the salon as well as at home. I have found that intensive treatments with a special pulsed iontophoresis machine, that has been recently patented, we can more effectively treat stretch marks. Under ideal condition, the skin should be treated for a minimum of three months before the operation. I found the best results when we did iontophoresis (and even sonophoresis) to the stretch marks once or twice a week for 20 minutes using both vitamin A and C, for a minimum of 16 treatments. Because the skin will be smooth, the final result after abdominal surgery will be better. For people with loose inelastic abdominal or thigh skin, treatments like this have no equal. 5. For the best results from liposuction the skin has to be as elastic as possible so that it can retract into the new shape. This is where high dose vitamin A (about 10,000 i.u. g%) is absolutely essential. Again I combine it with sodium or ammonium lactate to get the tightest skin. 3 6. If your client has rough thick facial skin, then it is appropriate to do a mild peeling treatment prior to any facial surgery (provided that the peeling is done in the cooler months!). One or two peels should be enough to make the skin more permeable so that the vitamins can take their effects. This is especially useful if your client is to have a dermabrasion or laser treatment. 7. While I personally do not believe in laser resurfacing, I know that the skin benefits enormously by being pre-treated with vitamin A. People with thick skin will be easier for their surgeon to treat if their facial skin has been peeled at least a month prior to surgery. I prefer to treat people with intensive vitamin A and C treatments with iontophoresis and sonophoresis. 8. If the client is to have a skin graft done then you can treat both the area that is to be excised, and also the donor area of the skin graft. This will ensure rapid healing and a healthier donor site. One of the real benefits for clients who have sun-sensitive skin, is that if you have put them on vitamin A restorative skin care at an early stage, then you will most likely have significantly reduced their chances of getting a skin cancer. Clients with solar keratoses will also benefit and may easily develop smooth skin within eight to twelve months. POSTOPERATIVE CARE 1. Facelift surgery: As soon as the surgeon permits, then start using the routine day creams to maintain healthy doses of vitamin A and the antioxidants in the skin. Iontophoresis will also stimulate lymphatic drainage so this may be started within a week of surgery. Special delicate massages also promote lymphatic drainage and should be recommended. However, bear in mind that after facial surgery the lymph will drain towards the nose rather than towards the ears. 2. For augmentation mammaplasty, reduction mammaplasty and abdominoplasty I prefer to support the scars with micropore® for a prolonged period (in some cases, even three months!) after the operation. The vitamin A and/or vitamin C preparation can be applied to the surface of the micropore® and some will permeate through to the surface of the skin. The tapes should be removed and replaced when they become loose. 3. After liposuction the skin has to retract into the new shape. Start using the vitamin A and sodium or ammonium lactate as soon as the bandages have been removed. 4. After laser resurfacing, or dermabrasion I soothe the skin with a vitamin A based gel, which cools the skin as well as promotes rapid healing and an earlier return to normal skin colour. Start iontophoresis and sonophoresis as soon as the skin is fully healed. Lymphatic drainage has an important role in many cases and should be encouraged. 4 THE SAFETY OF VITAMIN A I need to say something about the safety of topical vitamin A and particularly for pregnant mothers. Many people are worried that if they apply vitamin A to their skin that they could get vitamin A poisoning. Nothing could be further from the truth. The levels of vitamin A in the skin are generally higher than the levels in the blood so that means that there must be an active transport mechanism removing vitamin A from the blood and depositing it in the skin. The mechanism to take vitamin A from the skin and introduce it into the blood stream does not seem to exist in humans. Therefore, vitamin A that has been applied to skin is virtually trapped there and has to be used up by the skin cells. If the vitamin A could get into the blood stream, then the dose would be so tiny that it would be insignificant compared to the vitamin A that is readily absorbed from the diet. As far as pregnancy is concerned I personally believe that there is no risk at all in using retinyl esters (e.g. palmitate and acetate) on the skin to avoid the development of stretch marks. The esters of vitamin A cannot pass the placental barrier whereas retinol and retinoic acid can. However, after more than 35 years of using retinoic acid for the treatment of acne in young people, clinicians do not believe that the treatment is contraindicated in pregnancy. In order to avoid the mistaken attribution of a congenital abnormality to vitamin A, many manufacturers advise pregnant mothers not to use their preparation during the first trimester. Vitamins A and C, light peeling and scientific iontophoresis with sonophoresis are important tools to use in strengthening the bond between skin care therapists and plastic, cosmetic surgeons. 5