Curriculum Vitae
Michael J. Mazzini M.D.
ACADEMIC TRAINING:
1998 B.A.
University of Colorado, Boulder, CO; Summa Cum Laude, Molecular Cellular and
Developmental Biology
2002 M.D.
University of Colorado Health Sciences Center, Denver, CO
POSTDOCTORAL TRAINING:
2002-2003
Intern, Brigham and Women’s Hospital, Boston, MA
2003-2005
Resident, Brigham and Women’s Hospital, Boston, MA
2005-2008
Fellow, General Cardiology, Boston Medical Center, Boston, MA
2008-2010
Fellow, Clinical Electrophysiology, Boston Medical Center, Boston, MA
2009-2010
Post Doctoral Fellow, Whitaker Cardiovascular Institute, Boston University Medical
Center, Boston, MA. Mentor: Wilson Colucci, M.D.
ACADEMIC APPOINTMENTS:
2002-2005
Clinical Teaching Fellow in Medicine, Harvard Medical School
2005-2010
Teaching Instructor in Medicine, Boston University School of Medicine
2010-2011
Instructor in Medicine, Boston University School of Medicine
2011Assistant Professor of Medicine, Boston University School of Medicine
HOSPITAL APPOINTMENTS:
2007-2011
Physician, Melrose Wakefield Hospital, Melrose, MA
2007-2011
Physician, Winchester Hospital, Winchester, MA
2010-2011
Attending Physician, Boston Medical Center, Boston, MA
HONORS:
1997
1998
1999
1999
2000
2001
2002
2002
2008
2009
2009
2009
2010
Phi Beta Kappa
Summa Cum Laude, University of Colorado, Boulder, CO
UCHSC Student Research Forum Award, supported by UCHSC Department of Cell and
Structural Biology
Western Student Medical Research Committee Award
UCHSC Student Research Forum Award, supported by UCHSC Department of Medicine
Neil and Catherine Hamilton Medical Research Award
Joseph and Regina Glaser Award
Golden Headed Cane Award UCHSC School of Medicine Class of 2002
The Michael Bilitch Fellowship in Cardiac Pacing and Electrophysiology, Heart Rhythm
Society Fellowship
The Clinical Research Award in Honor of Mark Josephson and Hein Wellens, Heart
Rhythm Society Fellowship
First place, New England Electrophysiology Society Fellow’s Abstract Competition
Second place, Boston Medical Center Evans Research Day Clinical Abstract Competition
10th International Dead Sea Symposium Fellow’s Abstract Competition, Tel Aviv, Israel
LICENSES AND CERTIFICATION:
2004
Massachusetts License #223341
2006
American Board of Internal Medicine #263771
2008
Subspecialty Certification in Cardiovascular Disease #263771
2011
Subspecialty Certification Clinical Cardiac Electrophysiology #263771
CV: Michael J. Mazzini, M.D.
2/15/2016
2
DEPARTMENTAL AND UNIVERSITY COMMITTEES:
2004-2005
Intern Selection Committee, Brigham and Women’s Hospital, Boston, MA
2008-2010
Fellow Selection Committee, Boston Medical Center, Boston, MA
2008-2010
Medical Executive Committee, Boston Medical Center
2011Admissions Committee, Boston University School of Medicine
2011Institutional Review Board, Boston Medical Center
TEACHING EXPERIENCE AND RESPONSIBILITIES:
2003-2005
Regular lectures to house staff and medical students on general internal medicine,
Brigham and Women’s Hospital
2004-2005
Course Director, Intern Curriculum, Brigham and Women’s Hospital
2004-2005
Chief Medical Resident, West Roxbury VA Hospital, BWH/Harvard Section
2005-2011
Regular lectures to house staff in general cardiology and electrophysiology,
Boston Medical Center
2009-2011
Co-Director, Introduction to Arrhythmias and ECG Course, Boston University School of
Medicine
MAJOR ADMINISTRATIVE RESPONSIBILITIES:
N/A
OTHER PROFESSIONAL ACTIVITIES:
PROFESSIONAL SOCIETIES: MEMBERSHIPS, OFFICES, AND COMMITTEE ASSIGNMENTS
2002-2009
Massachusetts Medical Society
2005-2010
American College of Cardiology
2005-2010
American Heart Association
2007-2010
Heart Rhythm Society
EDITORIAL BOARDS:
N/A
MAJOR COMMITTEE ASSIGNMENTS:
Federal Government
N/A
Private/Foundation
2008-2010
Steering Committee, American Heart Association Fellows’ Society of Greater Boston
2010-2012
Clinical Electrophysiology and Electrocardiography Committee, American College of
Cardiology
Study Sections
N/A
State:
N/A
CV: Michael J. Mazzini, M.D.
2/15/2016
3
Current Other Support:
2010-2015
American Heart Association Fellow to Faculty Award (10FTF3720065): Fellowship phase:
50,000.00/yr salary support, 5000.00/yr mentor support, 10,000.00/year project support.
Faculty phase: 90,000.00/yr salary support, 5000.00/yr mentor support, and 25,000.00/yr
project support.
2011-2013
National Institute of Health/NHLBI LRP for Clinical Research. Oxidative peptide modifications
in patients with atrial fibrillation, diastolic heart failure, and metabolic disease. Loan
Repayment of 35,000.00/yr
2009-2011
National Institute of Health/NHLBI LRP for Clinical Research. Quantitative analysis of
microRNA expression in human atrial fibrillation. Loan Repayment of 35,000.00/yr
Past Other Support:
2009-2010
Heart Rhythm Society Fellowship Grant, Post transcriptional and translational regulation of
Connexin 43 in murine and human models of atrial hypertrophy and atrial fibrillation. Salary Support
50,000.00/yr
2008-2009
Heart Rhythm Society Fellowship Grant, Role of reactive oxygen species and neurohormonal
regulation on atrial structural remodeling. Salary Support 50,000.00/yr
Invited Lectures and Presentations
Dec 10, 2010
Mechanisms of Arrhythmogenesis in Metabolic Heart Disease. Evans Day Visiting
Professor Junior Faculty Research Seminar, Cardiovascular Medicine Section, Boston
University School of Medicine.
Aug 22, 2010
Role of Oxidative Stress in Electrical Remodeling and Arrhythmogenesis-Exploring
Targets in Mouse and Human Models of Disease. Whitaker Cardiovascular Institute
Seminar Series.
May 14, 2010
Oxidative Stress in Gq Mediated Myocardial Remodeling. 31st Annual Heart Rhythm
Annual Scientific Sessions Fellowship Award Section, 2010.
Mar 14, 2010
ACE inhibition: A Valuable Target in AF Prevention. American College of Cardiology
Scientific Sessions 2010. International Symposium: Canadian Society of Cardiology.
Feb 22, 2010
Ventricular Fibrillation in Primary Carnitine Deficiency: Evidence of Increased Oxidative
Stress. 10th International Dead Sea Symposium in Electrophysiology, Tel Aviv, Israel. 2010.
Dec 11, 2009
Transgenic Expression of Catalase Attenuates Gq Mediated Structural Atrial Remodling
and Spontaneous Atrial Arrhtyhmias. Boston Medical Center Evans Research Day
Dec 11, 2009
Ventricular Fibrillation in a 22 year-old Woman with Primary Carnitine (OCTN2)
Deficiency: A Novel Mutation and Evidence of Increased Oxidative Stress. Boston Medical
Center Evans Research Day
May 12, 2009
Connexin 43 is Oxidatively Modified in Response to Gq activation in vivo. 30th Annual
Heart Rhythm Annual Scientific Sessions Fellowship Award Section, 2009.
CV: Michael J. Mazzini, M.D.
2/15/2016
4
Bibliography:
ORIGINAL, PEER REVIEWED ARTICLES:
1. Mazzini M, Tadros T, Siwik D, Joseph L, Bristow M, Qin F, Cohen R, Monahan K , Klein M, and
Colucci W. Primary carnitine deficiency and sudden death: in vivo evidence of myocardial lipid
peroxidation and sulfonylation of SarcoEndoplasmic Reticulum Calcium ATPase 2 (SERCA2).
Cardiology. 2011;120(1):52-8
2. Lancel S, Qin F, Lennon SL, Zhang J, Tong X, Mazzini MJ, Kang YJ, Siwik DA, Cohen RA, and
Colucci WS. Oxidative Post-Translational Modifications Mediate Decreased SERCA Activity and
Myocyte Dysfunction in Gq-Overexpressing Mice Circ Res. 2010; 107: 228-232.
3. Magnani JW, Mazzini MJ, Sullivan L, Williamson M, Ellinor PT, Benjamin, EJ. P Wave Indices,
Distribution and Quality Control Assessment (from the Framingham Heart Study). Annals of
Noninvasive Electrocardiography. 2010. 15(1):77–84.
4. Mazzini MJ, Stevens GR, Whalen D, Ozonoff A, Balady GJ. Effect of an American Heart Association
Get with the Guidelines Program-Derived Clinical Pathway on Referral and Enrollment to Outpatient
Cardiac Rehabilitation after Acute Myocardial Infarction. 2008. Am J Cardiol. April 101(8):10841087.
5. Parikh H, Carlsson E, Chutkow WA, Johansson LE, Storgaard H, Poulsen P, Saxena R, Ladd C,
Schulze PC, Mazzini MJ, Jensen CB, Krook A, Björnholm M, Tornqvist H, Zierath JR, Ridderstråle
M, Altshuler D, Lee RT, Vaag A, Groop LC, Mootha VK.TXNIP Regulates Peripheral Glucose
Homeostasis in Humans. PLoS Medicine. 2007. May 4(5) e158.
6. Hardy PA, Mazzini MJ, Schweitzer C, Lundstrom K, Glode LM. Recombinant Semliki forest virus
infects and kills human prostate cancer cell lines and prostatic duct epithelial cells ex vivo. Int J Mol
Med. 2000 Mar;5(3):241-5.
CASE REPORTS, REVIEWS, CHAPTERS AND EDITORIALS
Proceedings of Meetings & Invited Papers:
1. Mazzini MJ, Luptak I, Qin F, Siwik DA, Cohen RA, Monahan KM, Colucci WS. Reactive Oxygen
Species Dependant Remodeling Of Action Potential In Gαq Overexpressing Mice. Heart Rhythm
2011. 32nd Annual Scientific Sessions Abstract 6816.
2. Tadros, TM, Mazzini, MJ, Klien, MW. Cardiac Arrest in a 22 year old Postpartum Female with
Carnitine Deficiency. American Heart Association Annual Scientific Sessions, Laennec Lecture.
Circulation. 2009;120:S747.
3. Magnani JW, Mazzini MJ, Sullivan L, Williamson M, Ellinor PT, Benjamin, EJ. Defining the
Epidemiology of P-Wave Dispersion and Duration: Assessment for Quality Control and
Measurement Precision. Joint Conference - 49th Cardiovascular Disease Epidemiology and
Prevention - and - Nutrition, Physical Activity, and Metabolism. Circulation. 2009;119;e271-e366.
CV: Michael J. Mazzini, M.D.
2/15/2016
5
Editorials and Critical Reviews
1. Mazzini MJ, Monahan, KM. Antiarrhythmic Pharmacotherapy for Atrial Fibrillation-Present and
Future. 2008. Heart Rhythm. June 5(6):S26-31.
2. Mazzini, MJ, and Schulze PC. Proatherogenic pathways leading to vascular calcification.
Eur J Radiol. 2006 Mar;57(3):384-9.
3. Pennell NA, Liu JF, Mazzini MJ. Interns' work hours.N Engl J Med. 2005 Feb 17;352(7):726-8;
Textbook Chapters:
N/A
TEXTBOOKS & Monographs:
N/A
TECHNOLOGY DISCLOSURES AND PATENTS:
2008: LeLorier, PA, Mazzini, MJ.US Patent 61/096494. Pacemaker with Neurocardiogenic Syncope Detection
and Therapy Utilizing Minute Ventilation Input.