UEBERSAX, JOHN SCOTT, PH.D.
CURRICULUM VITAE
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JOHN SCOTT UEBERSAX, PHD
ADDRESS
4500 Chabot Dr
Pleasanton, CA 93446
[email to get phone no.]
jsuebersax@gmail.com
http://www.john-uebersax.com
EDUCATION
PhD
1983
University of Texas at Austin; Behavioral Biostatistics
AB
1975
University of Southern California; Psychology,
Religion and Philosophy; valedictorian; Phi Beta
Kappa
SKILLS OVERVIEW
Clinical trials: Senior clinical trials statistician experienced in all aspects of Phase 3 and 4
studies, including planning and design, randomization, dataset development, production of
tables, listings and graphs, quality checking, final report preparation and regulatory
submission. Phase 1 and 2 and pre-clinical experience also.
Statistics/Biostatistics: Linear models; survival analysis; nonparametric analysis; power
analysis; Bayesian methods (including WinBUGS, PROC BGENMOD, PROC MCMC);
genetic data; diagnostics; latent structure analysis; test validation and comparison; reliability
and reproducibility studies categorical data; cluster analysis; factor analysis;.
Bioinformatics/computational methods. Micro-array data; sequence alignment; dynamic
programming; BLAST; optimization and numerical methods.
Computer science/bioinformatics. Artificial/machine intelligence; Bayes networks;
computational linguistics; automated content analysis; k-nearest neighbor prediction; hidden
Markov models.
Health economics. Quality-of-life assessment; cost-efficacy models; simulation; decision
analysis; triage; disease progression models; symptom inventories; Bayesian and classical
meta-analysis; psychometrics; item response theory and Rasch models; preference modeling.
Statistical programming. SAS (9.1; BASE, STAT, Macros); R/S-plus; PASS 2008;
StatXact; Fortran (90/95); JMP; WinBUGS; SQL; VBA; Excel.
Citizenship: United States
Language Skills: English; Spanish; French (read/write); German (read/write)
UEBERSAX, JOHN SCOTT, PH.D.
CURRICULUM VITAE
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WORK HISTORY
Consulting Principal Biotatistician, ROCHE MOLECULAR SYSTEMS, Pleasanton, California
September 2009 – March 2010
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Validation of polymerase chain reaction-based in vitro diagnostic devices
Simulation and modeling to support clinical trial and study planning
Statistical Analysis Plans, responses to regulatory agencies
Bland-Altman analysis; Deming regression; dose-response modeling
Scientific programming (SAS, Splus, JMP, VBA)
Senior Statistician, GLAXOSMITHKLINE BIOLOGICALS, Rixensart, Belgium
March 2008 - March 2009.
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Analysis of seasonal and pandemic flu vaccine efficacy/immunogenicity/safety
Bayesian and classical statistical analysis of Phase 3 clinical trials
Used statistical simulations to double throughput of critical antibody (HA) assay
Multivariate modeling of cell-mediated (T- and B-cell) immune response
Statistical Analysis Plans and Statistical Reports
SAS (BASE/Stat/Macro) programming
Senior Statistician, UCB PHARMACEUTICALS, Braine-l'Alleud, Belgium, May 2007 - November
2007.
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Protocol review, Analysis Datasets, Tables, Listings, Graph, Data Definition Tables
Quality checking of programmer results
Quality-of-Life analyses
SAS statistical programming to support Phase 3 clinical trials (CNS; dermatology)
Sabbatical research, Marbella, Spain, March 2005 - April 2007.
Research topic: Classical Greek philosophy
Senior Scientist, RAVENPACK ANALYTICS SL, Marbella, Spain, June 2003 - Feb 2005.
Artificial intelligence design, algorithm development, and statistical modeling for healthcare
and economic consulting agency
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Hidden Markov models, artificial neural networks, k-nearest neighbors analysis
Computational linguistics and automated content analysis
Developed Bayes network expert system to estimate breast cancer risk given family
history and genetic (BRCA1) data
Statistical programming in Fortran 90 and SAS
Technical writing and proposal development
Supervision of/collaboration with scientific programmers
UEBERSAX, JOHN SCOTT, PH.D.
CURRICULUM VITAE
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Senior Statistician, W. L. GORE AND ASSOCIATES, Medical Products Division, Flagstaff, AZ,
3/2003-6/2003.
Phase 3 clinical trials of medical devices (arterial stents)
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Design of noninferiority clinical trials, Statistical Analysis Plans, CRF design
Bayesian sample size and statistical power modeling for medical device clinical trials
Survival analysis and life table modeling (SAS)
Sample size and power estimation using PASS
Senior Statistician, LA JOLLA PHARMACEUTICAL COMPANY, San Diego, CA, 2/2002-2/2003.
Senior Statistician supporting Phase 3 clinical trials; autoimmune disease (SLE).
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Design of clinical trials
Quality-of-Life assessment
Statistical Analysis Plans, Final Reports, Table Templates, Data Definition Tables
SAS programming; supervision of clinical programmers
Program and dataset quality checking
Senior Statistician, WELLPOINT HEALTH NETWORKS, Camarillo, CA, 5/2001-2/2002.
Health outcomes research and health policy analysis for California’s largest public health
insurer.
Senior Statistical Programmer, 1997-2001
Contract statistical and software support for clinical trials data analysis, design and results
submission. Principle clients included:
AMGEN, INC., Thousand Oaks, CA
ABBOTT LABORATORIES, Abbott Park, IL
A.R. KAMM &ASSOCIATES, INC., Cary, NC
QUINTILES, Lenexa, KS
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SAS programming (Base, Stat, Macros)
Preparation of tables, listings, figures, table shells
S-Plus
Independent research, Flagstaff, AZ, 1994-1996
Original research, software development, and writing concerned with new statistical methods
for categorical data analysis. Developed statistics web sites and software; research and online
publications on categorical data methods.
Associate Professor of Public Health (Biostatistics), BOWMAN GRAY SCHOOL OF MEDICINE OF
WAKE FOREST UNIVERSITY, Winston-Salem, NC, 1991-1994.
UEBERSAX, JOHN SCOTT, PH.D.
CURRICULUM VITAE
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Analyzed outcomes in clinical trials comparing pharmacological, surgical, and behavioral
treatments for urinary incontinence; developed new ways to construct quality-of-life
assessment scales; survey research; SAS programming
Associate Analyst-Statistician, RAND CORPORATION, Santa Monica, CA, 1987-1991.
Modeling and statistical analysis to support policy research
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Developed new techniques for measuring health outcome preferences
Designed workstation for multi-attribute decision theory
Methodological refinements of Delphi method
Markov and survival models of symptom progression in Alzheimer’s disease
Developed taxonomy of occupational categories
Research grant and report writing
SAS and Fortran statistical programming
Research Assistant Professor, CENTER FOR HEALTH POLICY RESEARCH AND EDUCATION, Duke
University, Durham, NC, 1985-1986.
Bayesian methods for meta-analysis of clinical trials and treatment efficacy analysis.
Statistical Computing Consultant, UNIVERSITY OF TEXAS COMPUTATION CENTER, Austin, TX,
1983-1985.
Directed statistics consulting service for university faculty and students.
PROFESSIONAL
American Statistical Association
Biometric Society
STATISTICS WEB SITES
Statistical Methods for Rater Agreement
Latent Structure Analysis web pages
BIBLIOGRAPHY
ONLINE PUBLICATIONS (selected)
Uebersax JS. The tetrachoric and polychoric correlation coefficients. Online article, 2006.
Uebersax JS. Likert scales: dispelling the confusion. Online article, 2006.
Uebersax JS. A practical guide to conditional dependence in latent class models. Web
publication, 2000.
UEBERSAX, JOHN SCOTT, PH.D.
CURRICULUM VITAE
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ARTICLES, CHAPTERS, REPORTS
Perri F, Zagari RM, Uebersax JS, Quitadamo M, Bazzoli F. Helicobacter Pylori Sige Study
Group on 13CO2 Measurement Standardization. An inter- and intra-laboratory comparison of
breath 13CO2 analysis. Aliment Pharmacol Ther. 2003 May 15;17(10):1291-7.
Uebersax JS. Probit latent class analysis. Applied Psychological Measurement, 1999, 23, 283297.
Wyman JF, McClish DK, Fantl JA, Uebersax JS, et al., Quality of life following bladder training
in older women with urinary incontinence. International Urogynecological Journal, 1997, 8,
223-229.
Uebersax JS. Latent class analysis and latent trait analysis of student problem behaviors. In
Langeheine R & Rost J (eds), Applications of Latent Class and Latent Trait Models. New York:
Waxman, 1997.
Hadorn DC, Uebersax JS. Large-scale health outcomes evaluation: How should quality of life
be measured? Part I--Calibration of a brief questionnaire and a search for preference subgroups.
Journal of Clinical Epidemiology, 1995, 48, 607-618.
Uebersax JS, Wyman JF, Shumaker D, McClish DK, Fantl JA. Short forms to assess life quality
and symptom distress for urinary incontinence in women: The Incontinence Impact
Questionnaire and the Urogenital Distress Inventory. Neurology and Urodynamics, 1995, 14,
131-139.
Shumaker SA, Wyman JF, Uebersax JS, McClish DK, Fantl JA. Health-related quality of life
measures for women with urinary incontinence. The Urogenital Distress Inventory and the
Incontinence Impact Questionnaire. Quality of Life Research, 1994, 3, 291-306.
Uebersax JS. Latent class analysis of substance abuse patterns. In Collins L & Seitz L (eds),
Advances in Data Analysis for Prevention Intervention Research. NIDA research monograph
series. Bethesda: NIDA, 1994.
Uebersax JS. Statistical modeling of expert ratings on medical treatment appropriateness.
Journal of the American Statistical Association, 1993, 88, 421-427.
Uebersax JS, Grove WM. A latent trait finite mixture model for the analysis of rating agreement.
Biometrics, 1993, 49, 823-835.
Uebersax JS. A review of modeling approaches for the analysis of observer agreement.
Investigative Radiology, 1992, 17, 738-743.
Hadorn DC, Hays RD, Uebersax JS, Hauber T. Improving task comprehension in the
measurement of health state preferences. Journal of Clinical Epidemiology, 1992, 45, 233-243.
Winkler JD, Kirin SJ, Uebersax JS. Linking future training concepts to Army individual training
programs. The RAND Corporation, R-4228-A, 1992.
UEBERSAX, JOHN SCOTT, PH.D.
CURRICULUM VITAE
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Uebersax JS, Grove WM. Latent class analysis of diagnostic agreement. Statistics in Medicine,
1990, 9, 559-572.
Uebersax JS. ADAMHA and NIH research grants to psychologists. The RAND Corporation,
N-3031-APA, November 1989.
Uebersax JS, Grove WM. Latent structure agreement analysis. The RAND Corporation,
N-3029-RC, November 1989.
Uebersax JS. PANEL user's manual. The RAND Corporation, N-3030-RC, November 1989.
Uebersax JS. Validity inferences from interobserver agreement. Psychological Bulletin, 1988,
104, 405-416.
Biddle A, Carter GM, Uebersax JS, Winkler JD. Research careers of recipients of the research
scientist and the research scientist development awards. The RAND Corporation,
R-3688-NIMH, October 1988.
Uebersax JS. Diversity of decision-making models and the measurement of interrater agreement.
Psychological Bulletin, 1987, 101, 140-146.
Uebersax JS. Structural analysis of diagnostic disagreements. Journal of Nervous and Mental
Disease, 1983, 171, 199-206.
Uebersax JS. A design-independent method for measuring the reliability of psychiatric
diagnosis. Journal of Psychiatric Research, 1983, 17, 335-342.
Uebersax JS. A generalized kappa coefficient. Educational and Psychological Measurement,
1982, 42, 181-183.
Penk WE, Uebersax JS, Charles HL, Andrews RH. Psychological aspects of data loss in
outcome research. Evaluation Review, 1981, 5, 392-396.
Penk WE, Uebersax JS, Andrews RH, Charles HL. Client correlates of community informant
adjustment ratings. Journal of Personality Assessment, 1980, 44, 157-164.
TECHNICAL PAPERS
Uebersax JS. Predicting breast cancer from pedigree and genetic test data: an application of
Bayes nets; July 2004.
Uebersax JS. A Bayesian network expert system for diagnosis of prostate cancer. Marbella,
Spain: RavenPack Analytics; July 2004.
Uebersax JS. Comparison of Bayesian networks and neural networks in expert system
medical diagnosis. Marbella, Spain: RavenPack Analytics; July 2004.
Uebersax JS. Latent class agreement analysis with ordered rating categories. The RAND
UEBERSAX, JOHN SCOTT, PH.D.
CURRICULUM VITAE
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Corporation, P-7694, February 1991.
Uebersax JS. Quantitative methods for the analysis of observer agreement: Toward a
unifying model. The RAND Corporation, P-7686, February 1991.
Uebersax JS, Poulsen CS, Sobel E, Henderson V. The mixed Markov and related stochastic
models for the analysis of disease progression. The RAND Corporation, P-7671, September
1990.
Uebersax JS. Contributions of humanistic psychology to drug policy. The RAND
Corporation, IN-25777-RC, April 1990.
Uebersax JS. Reliability, validity and the kappa coefficient. Center for Statistical Sciences,
University of Texas at Austin, Technical Report #12, 1984.
PRESENTATIONS
Uebersax JS. A unifying framework for mixture models with categorical variables. Annual
meeting of the Biometric Society, Eastern North America Region, Cleveland, April 1994.
Uebersax JS. Dimension reduction and latent class analysis.
Classification Society of North America, Pittsburgh, June 1993.
Annual meeting of the
Uebersax JS, Ingmundson P. Quantitative phenomenology: An agenda for the '80s. Annual
meeting of the American Psychological Association, Los Angeles, August 1981.
STATISTICAL SOFTWARE
BayesDx: Bayesian medical diagnosis using discrete and continuous data. RavenPack
technical report, June 2004.
POLYCORR: Estimation of the polychoric correlation coefficient (basic and advanced
versions), 2000.
GLC: Estimate generalized latent correlation, 2008.
LLCA: Located Latent Class Analysis, 1993 (available from StatLib).
MVN: Generate random multivariate normal numbers easily, 2006
MH Program: Nonparametric tests of marginal homogeneity in two-way tables, 2000.
PAIR: A program for scaling based on graded paired comparisons., 1992 (available from
StatLib).
ABSTRACTS, LETTERS
UEBERSAX, JOHN SCOTT, PH.D.
CURRICULUM VITAE
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Uebersax JS. PANEL: Latent class modeling of interrater agreement (computer program
abstract). Applied Psychological Measurement, 1988, 48, 321.
Uebersax JS. Measuring diagnostic reliability: Reply to Spitznagel and Helzer (letter). Archives
of General Psychiatry, 1987, 44, 193-194.
Uebersax JS. The efficacy of electroconvulsive therapy re-examined (letter). American Journal
of Psychiatry, 1987, 144, 255-256.
Uebersax JS. Bibliographic database management system for specialized research (computer
program abstract). Applied Psychological Measurement, 1984, 8, 322.
Uebersax JS. GKAPPA: Generalized kappa coefficient (computer program abstract). Applied
Psychological Measurement, 1983, 5, 28.
REVIEWER FOR
Journal of the American Statistical Association, Biometrics, Statistics in Medicine, Journal of
the Royal Statistical Society, Computational Linguistics, Psychometrika, Journal of Applied
Social Psychology, Multivariate Behavioral Research, Psychological Assessment,
Psychological Bulletin, Psychological Methods, Quality of Life Research, National Institute
of Mental Health, National Science Foundation.
SAS_Uebersax_John_cv.doc: February 15, 2016