Last data updates: 06 January 2011
Tian, J.H. and Han, J.S. (2000), Functional studies using antibodies against orphanin FQ/nociceptin.
Peptides, 21 (7), 1047-1050.
Document type: Article Language: English Cited references: 20 Time cited: 15 Times self cited: 1
Abstract: Orphanin FQ/nociceptin (OFQ) is a recently discovered endogenous ligand for the novel
opioid receptor-like receptor (ORL-1). There are numerous reports in the literature demonstrating
paradoxical effects of exogenous OFQ on pain modulation. For example, OFQ produces a
pronociceptive effect in the brain and an analgesic effect in the spinal cord. In order to better
understand the physiological actions of OFQ, the present study focused on the pain-modulatory
effect of endogenously released OFQ measured using antibody microinjection techniques. We found
that electroacupuncture analgesia (EA) was increased by intracerebroventricular (i.c.v.) injection of
an OFQ;antibody and decreased following intrathecal injection. Furthermore, i.c.v. OFQ-antibody
partially reversed tolerance to both chronic morphine and chronic EA. These data suggest that
endogenously released OFQ plays an important role in pain modulation, where pain sensitivity in
the brain and spinal cord is increased and decreased, respectively. (C) 2000 Elsevier Science Inc.
All rights reserved.
Author Keywords: orphanin FQ; nociceptin; antibody; pain; tolerance
keywords plus: anti-opioid peptide; rat spinal-cord; nociceptin receptor; induced analgesia;
electroacupuncture analgesia; periaqueductal gray; in-vivo; fq; agonist;
<phe(1)psi(ch2-nh)gly(2)>nociceptin-(1-13)-nh2
Reprint Address: Han, JS (reprint author), Beijing Med Univ, Neurosci Res Inst, Beijing 100083,
Peoples R China
Addresses:
1. Beijing Med Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
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