CURRICULUM VITAE
Guoxing Zheng, Ph.D.
Personal Data:
Work address:
Phone:
Fax:
E-mail:
Department of Biomedical Sciences, Room E621
University of Illinois College of Medicine at Rockford
1601 Parkview Avenue
Rockford, IL 61107
(815) 395-5691
(815) 395-5666
guoxingz@uic.edu
Faculty Appointment:
Associate Professor, Department of Biomedical Sciences, University of
Illinois, College of Medicine at Rockford
Patents:
1. Tykocinski M. L., Chen A., and Zheng G. Method for protein transfer. U.S. Patent
6316256, issued in 2001.
2. Tykocinski M. L and Zheng G. Auto-stimulating cells and methods for making and using
the same. U.S. Patent 7435585, issued in 2008.
3. Zheng G. and Chen A. Method of stimulating proliferation of regulatory T cells in a
diabetic mammal. U.S. Patent 7592313, issued in 2009.
Publications:
1. Zheng G. and Sinden R. R.* Effect of base composition at the center of inverted repeated
DNA sequences on cruciform transitions in DNA. Journal of Biological Chemistry,
263:5356-61, 1988.
2. Sinden R. R.*, Zheng G., Brankamp R. G., and Allen K. N. On the deletion of inverted
repeated DNA in Escherichia coli: effects of length, thermal stability, and cruciform
formation in vivo. Genetics, 129:991-1005, 1991.
3. Zheng G., Kochel T., Hoepfner R. W., Timmons S. E., and Sinden R. R.* Torsionally tuned
cruciform and Z-DNA probes for measuring unrestrained supercoiling at specific sites in
DNA of living cells. Journal of Molecular Biology, 221:107-22, 1991.
4. Zheng G., Ussery D. W., and Sinden R. R.* Estimation of superhelical density in vivo from
analysis of the level of cruciforms existing in living cells. Journal of Molecular Biology,
221:122-9, 1991.
5. Zheng G., Teumer J., Colmenares C., Richmond C., and Stavnezer E.* Identification of a
core functional and structural domain of the v-Ski oncoprotein responsible for both
transformation and myogenesis. Oncogene, 15:459-71, 1997.
6. Tarapore P., Richmond C., Zheng G, Cohen S. B., Kelder B., Kopchik J., Kruse U., Sippel
A., Colmenares C., and Stavnezer E.* DNA binding and transcriptional activation by the Ski
oncoprotein mediated by interaction with NF1. Nucleic Acid Research, 25:3895-903, 1997.
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7. Zheng G., Blumenthal K. M., Ji Y., Shardy D. L., Cohen S. B., and Stavnezer E.* High
affinity dimerization by Ski involves parallel pairing of a novel bipartite alpha-helical
domain. Journal of Biological Chemistry, 272:31855-64, 1997.
8. Cohen, S. B., Zheng G., Heyman H.C., and Stavnezer E.* Heterodimers of the SnoN and
Ski oncoproteins form preferentially over homodimers and are more potent transforming
agents. Nucleic Acid Research, 27:1006-14, 1999.
9. Nicol R., Zheng G., Sutrave P., Foster D. N., and Stavnezer E.* Association of specific
DNA binding and transcriptional repression with the transforming and myogenic activities
of c-Ski. Cell Growth and Differentiation, 10: 243-54, 1999.
10. Chen A., Zheng G., and Tykocinski M. L.* Hierarchical costimulator thresholds for distinct
immune responses: application of a novel two-step Fc fusion protein transfer method.
Journal of Immunology, 164:705-11, 2000.
11. Zheng G., Chen A., Sterner R. E., Zhang P. J., Pan T., Kiyatkin N., and Tykocinski M. L.*
Induction of anti-tumor immunity via intratumoral tetra-costimulator protein transfer.
Cancer Research, 61:8127-34, 2001.
12. Tykocinski M. L.*, Chen A., Huang J., Weber M. C., and Zheng G. New designs for cancer
vaccine and artificial veto cells. Immunologic Research, 27:565-74, 2003.
13. Chen A., Zheng G., Neumann A., and Tykocinski, M. L.* Quantitative balance between
costimulator and FasL modulates final outcome of T cell proliferation. Cell. Immunol.,
221:128-37, 2003.
14. Chen A.*, Xu H., Choi Y., Wang, B., and Zheng G. TRANCE counteracts FasL-mediated
apoptosis of murine bone marrow-derived dendritic cells. Cellular Immunology, 231:40-8,
2004.
15. Zheng G.*, Wang, B., and Chen A. 4-1BB costimulation augments the proliferation of
CD4+CD25+ regulatory T cells. Journal of Immunology, 173:2428-34, 2004.
16. Jin H., Kang Y., Zheng G., Xie Q., Xiao C., Zhang X., Yu Y., Zhu K., Zhao G., Zhang F.,
Chen A., and Wang B. Induction of active immune suppression by co-immunization with
DNA- and protein-based vaccines. Virology, 337:183-91, 2005.
17. Kang Y., Jin H., Zheng G., Xie Q., Yin J., Yu Y., Xiao C., Zhang X., Chen A., and Wang
B. The adjuvant effect of levamisole on killed viral vaccines. Vaccine, 23:5543-50, 2005.
18. Zheng G.*, Liu S., Wang P., Xu Y., and Chen A.* Arming tumor-reactive T cells with
costimulator B7-1 enhances therapeutic efficacy of the T cells. Cancer Research, 66:6793-9,
2006.
19. Chen A.*, Liu S., Park, D., Kang Y., and Zheng G.* Depleting intratumoral CD4+CD25+
regulatory T cells via FasL protein transfer enhances efficacy of adoptive T cell transfer.
Cancer Research, 67:1291-98, 2007.
20. Liu S., Foster B., Chen T., Zheng G.*, and Chen A.* Modifying dendritic cells via protein
transfer for antitumor therapeutics. Clinic Cancer Research, 13:283-91, 2007.
21. Kang Y., Jin H., Zheng G., Du X., Xiao C., Zhang X., Geng S., Li X., Wang J., Chen A.,
and Wang B. Co-inoculation of DNA and protein vaccines induces antigen-specific T cell
suppression. Biochemical and Biophysical Research Communications, 353:1034-9, 2007.
22. Du, X., Zheng, G., Jin, H., Kang, Y., Wang, J., Xiao, C., Zhang, S., Zhao, L., Chen, A., and
Wang, B. The adjuvant effects of co-stimulatory molecules on cellular and memory
responses to HBsAg DNA vaccination. Journal of Gene Medicine, 9:136-46, 2007.
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23. Liu S., Breiter D., Zheng G.*, and Chen A.* Enhanced antitumor responses elicited by
combinatorial protein transfer of chemotactic and costimulatory molecules. Journal of
Immunology, 178:3301-6, 2007.
24. Kang Y., Xu L., Wang B., Chen A.*, and Zheng G.* Cutting edge: immunosuppressant as
adjuvant for tolerogenic immunization. Journal of Immunology, 180:5172-6, 2008.
25. Kang Y., Chen A., Wang B.*, and Zheng G.* Protein transfer enhances cellular immune
responses to DNA vaccination against SARS-CoV. Viral Immunology, 22:417-22, 2009.
26. Gnanasekar M.*, Thirugnanam S., Zheng G., Chen A., and Ramaswamy K.* T-oligo
induces apoptosis in advanced prostate cancer cells. Oligonucleotides, 19:287-92, 2009.
27. Gnanasekar M.*, Thirugnanam S., Zheng G., Chen A., and Ramaswamy K.* Gene silencing
of translationally controlled tumor protein (TCTP) by siRNA inhibits cell growth and
induces apoptosis of human prostate cancer cells. International Journal of Oncology,
34:1241-6, 2009.
28. Kang Y., Zhao J., Liu Y., Chen A., Zheng G., Yu Y., Mi J., Zou Q., and Wang B.* FK506
as an adjuvant of tolerogenic DNA vaccination for the prevention of experimental
autoimmune encephalomyelitis. Journal of Gene Medicine, 11:1064-70, 2009.
29. Zou Q., Yao X., Feng J., Yin Z., Flavell R., Hu Y., Zheng G., Jin J., Kang Y., Wu B., Liang
X., Feng C., Liu H., Li W., Wang X., Wen Y., and Wang B.* Praziquantel facilitates IFN-γproducing CD8+ T cells (Tc1) and IL-17-producing CD8+ T cells (Tc17) responses to DNA
vaccination in mice. PLoS One, 6:e25525, 2011.
30. Shetty A. V., Thirugnanam S., Dakshinamoorthy G., Samykutty A., Zheng G., Chen A.,
Bosland M. C., Kajdacsy-Balla A., and Gnanasekar M.* 18α-glycyrrhetinic acid targets
prostate cancer cells by down-regulating inflammation-related genes. International Journal
of Oncology, 39:635-40, 2011.
31. Elangovan I., Thirugnanam S., Chen A., Zheng G., Bosland M. C., Kajdacsy-Balla A., and
Gnanasekar M.* Targeting receptor for advanced glycation end products (RAGE)
expression induces apoptosis and inhibits prostate tumor growth. Biochemical Biophysical
Research Communications, 417:1133-8, 2012.
32. Kang Y., Zheng G., Chen A., Wang J., Hu Y., Li J., Zhang J., Gao W., Fu H., Xia G., and
Wang B.* Tolerogenic DNA Vaccine for Prevention of Autoimmune Ovarian Disease.
Immunological Investigations, 41:249-60, 2012.
33. Li J., Geng S., Xie X., Liu H., Zheng G., Sun X., Zhao G., Wan Y., Wu Y., Chen X., Zhong
Y., and Wang B.* Caveolin-1-mediated negative signaling plays a critical role in the
induction of regulatory dendritic cells by DNA and protein co-immunization. Journal of
Immunology, 189:2852-9, 2012.
34. Zheng G.*, Zhong S., Geng Y., Gnanasekar M., Cha I., Reardon C., Getz G. S., Rooijen N.,
Kang Y., Wang B., and Chen A.* Dexamethasone promotes tolerance in vivo by enriching
CD11cloCD40lo tolerogenic macrophages. European Journal of Immunology, 43:219-27,
2013.
35. Chou S. H., Shetty A. V., Geng Y., Xu L., Gnanasekar M., Pipathsouk A., Tan I., Morris T.,
Wang B., Chen A.,* and Zheng G.* Palmitate-derivatized human IL-2: A less toxic anticancer immunotherapeutic. Cancer Immunology & Immunotherapy, 62:597-603, 2013.
36. Gnanasekar M.,* Kalyanasundaram R., Zheng G., Chen A., Bosland M. C., Kajdacsy-Balla
A. HMGB1: a promising therapeutic target for prostate cancer. Prostate Cancer,
2013:157103, 2013.
37. Samykutty A., Shetty A. V., Dakshinamoorthy G., Bartik M. M., Johnson G. L., Webb B.,
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Zheng G., Chen A., Kalyanasundaram R., Munirathinam G.* Piperine, a bioactive
component of pepper spice exerts therapeutic effects on androgen dependent and androgen
independent prostate cancer cells. PLoS One, 8:e65889, 2013.
38. Samykutty A., Shetty A. V., Dakshinamoorthy G., Kalyanasundaram R., Zheng G., Chen
A., Bosland M. C., Kajdacsy-Balla A., and Gnanasekar M.* Vitamin k2, a naturally
occurring menaquinone, exerts therapeutic effects on both hormone-dependent and
hormone-independent prostate cancer cells. Evidence Based Complement Alternative
Medicine, 2013:287358, 2013.
39. Srinivasan M., Banerjee S., Palmer A., Zheng G., Chen A., Bosland M. C., Kajdacsy-Balla
A., Kalyanasundaram R., and Munirathinam G.* HMGB1 in hormone-related cancer: a
potential therapeutic target. Hormonal Cancer, 5: 127-39, 2014.
40. Chen A.,* Geng Y., Ke H., Constant L., Yan Z., Tan I., Lee P., Williams K., George S.,
Gnanasekar M., Reardon K., Getz G. S., Wang B., and Zheng G.* Cutting Edge:
Dexamethasone potentiates the responses of both regulatory T cells and B-1 cells to antigen
immunization in the ApoE(-/-) mouse model of atherosclerosis. Journal of Immunology,
193: 35-9, 2014.
*Indicates corresponding author(s)
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