CURRICULUM VITAE
William Julian Pearce
EDUCATION:
B.S.
Ph.D.
1974, University of Michigan, Ann Arbor, MI
Major: Zoology; Minor: English Literature
1979 (Physiology), University of Michigan, Ann Arbor, MI.
Dissertation Title: “Reflex Sympathetic Cerebral
Vasoconstriction.”
FELLOWSHIPS, SCHOLARSHIPS & SABBATICALS:
Muscular Dystrophy Fellow, Department of Physiology, University of Michigan, Ann Arbor,
Michigan 1975.
National Research Services Award, Department of Physiology, University of Michigan, Ann
Arbor, Michigan 1976-1978.
American Heart Association Post-Doctoral Fellow in the laboratory of R.R. Sonnenschein, M.D.,
Ph.D., Department of Physiology, University of California, Los Angeles, 1978-1980.
NIH Fellow in the laboratory of J.A. Bevan, M.D., Department of Pharmacology, University of
California, Los Angeles, 1981-1982.
Visiting Sabbatical Professor, CNRS/INSERM Laboratory of Cerebrovascular Physiology and
Pathophysiology, Paris, France, 1987-1988.
EMPLOYMENT HISTORY:
1972 - 1973
Cytologist and Autopsy Aide, Department of Pathology, Veterans
Administration Hospital, Ann Arbor, Michigan.
1974
Renin Radioimmunoassayist (work-study student), Clinical Hypertension Unit,
University Hospital, Ann Arbor, Michigan.
1975
Hematology Technician, Department of Hematology, University Hospital, Ann
Arbor, Michigan.
1979 - 1980
Lab Instructor, Department of Physiology, UCLA
1982 - 1988
Director of Research, White Memorial Medical Center, Los Angeles,
California.
1983 - 1988
Assistant Research Professor of Physiology, School of Medicine, Loma Linda
University, Loma Linda, California.
1988 - 1992
Assistant Professor of Physiology and Pharmacology, School of Medicine,
Loma Linda University, Loma Linda, California.
1992 - 1996
Associate Professor of Physiology and Pharmacology, School of Medicine,
Loma Linda University, Loma Linda, California.
1996 - 1997
Associate Professor of Physiology, Pharmacology, and Biochemistry, School
of Medicine, Loma Linda University, Loma Linda, California.
1997 - Present Professor of Physiology, Pharmacology, and Biochemistry, School of
Medicine, Loma Linda University, Loma Linda, California.
Curriculum Vitae: William Julian Pearce
EDITORIAL, ORGANIZATIONAL, & GRANT REVIEW EXPERIENCE:
1983 - 1988
1994
1994 - 1997
1995 - 1999
1997
1997 - 1998
1997 - 1998
1998
1999
1999 - present
2000
2000
2000
2000
2000 - 2001
2001 - present
2002
2002
2002 - 2007
2003
2005
2006
2006 – present
2007 – present
2008
2008 - present
2009 – present
2009
2009
2009
Founding Member, Board of Directors, Cyanotic Heart Association of Southern California.
Member, Program Project Review Study Section, Medical Research Council of Canada.
Member, Grant Review Study Section of the California Affiliate of the American Heart
Association.
Member, Board of Editors, American Journal of Physiology: Heart and Circulatory
Physiology.
Meeting Organizer for “Mechanisms of Cerebrovascular Function and Regulation”, a satellite
of the International Society of Cerebral Blood Flow and Metabolism, held in
Williamsburg, VA, 6/20/97 - 6/22/97.
Member, Program Project Review Study Section for Cerebrovascular Sciences, National
Institutes of Health.
Member, Research Committee for the California Affiliate of the American Heart Association.
Ad Hoc Reviewer, HED-1 Study Section, National Institutes of Health.
Ad Hoc Reviewer, ECS Study Section, National Institutes of Health.
Member, Board of Editors, American Journal of Physiology: Cell Physiology.
Member, Special Emphasis Panel: Cardiovascular and Renal Study Section, National
Institutes of Health
Member, RFA Study Section: Oxygen Sensing During Intermittent Hypoxia, National
Institutes of Health
Ad Hoc Reviewer, ECS Study Section, National Institutes of Health.
Ad Hoc Reviewer, HED-1 Study Section, National Institutes of Health.
Member, Program Project Review Study Section for NHLBI: “Toxic and Therapeutic Effects
of Oxygen”
Member, Board of Editors, American Journal of Physiology: Heart and Circulatory
Physiology.
Meeting Organizer for “Developmental Cerebral Blood Flow and Metabolism”, held in
Hershey, PA 6/6/02 – 6/9/20
Meeting Organizer for “Vascular Neuroeffector Mechanisms”, a satellite of the International
Union of Pharmacology, held in Lake Tahoe, CA, 7/12/02–7/15/02.
Member, BDCN5/DBD Study Section, National Institutes of Health.
Member, Organizing Committee for the 30 th Fetal and Neonatal Physiological Society
meeting, held in Banff, Alberta from 7/4/03 – 7/8/03.
Member, Center Project Review Study Section of NICHHD: “Fetal Oxygenation”
Member, Program Project Review Study Section for NHLBI: “Oxygen, Nitric Oxide, and
Carbon Monoxide Signaling”
Member, Brain-3 Study Section, American Heart Association, National Affiliate
Member, NCRR COBRE Study Section, National Institutes of Health
Member, Special Emphasis Panel: Maternal-Fetal Adaptations to Hypoxemia, NIH/NICHHD
Member, Board of Editors, Journal of Cerebral Blood Flow and Metabolism.
Section Head, Faculty of 1000: Pharmacology & Drug Discovery
Ad Hoc Reviewer, DBD Study Section, National Instututes of Health
Ad Hoc Reviewer, ZRG1-BDCNM(95) Special Emphasis Panel, NIH
Ad Hoc Reviewer, CIDO/EMNR Study Sections: Challenge Grants
Peer-Reviewed Journals Served as a Field Referee (Since 2000):
American Journal of Obstetrics and Gynecology; American Journal of Physiology, Heart (Editorial Board
Member); American Journal of Physiology, Cell (Editorial Board Member); Arteriosclerosis, Thrombosis,
and Vascular Biology; Biology of the Neonate; Brain Research; British Journal of Pharmacology;
Cephalgia; Developmental Brain Research; Developmental Origins of Human Disease; Early Human
Development; European Journal of Pharmacology; Experimental Neurology; Hypertension; Japanese
Journal of Pharmacology; Journal of Applied Physiology; Journal of Cerebral Blood Flow and
Metabolism (Editorial Board Member); Journal of Neurochemistry; Journal of Neuroscience Methods;
Journal of Physiology (London); Journal of the Society for Gynecological Investigation; Journal of
Vascular Research; Life Sciences; Microcirculation; Neonatology; Neurobiology of Disease;
Neuroscience; Pediatric Research; Pflugers Archives; Pulmonary Pharmacology and Therapeutics;
Physiological Genomics; Pulmonary Pharmacology and Therapeutics; Reproductive Sciences; Stroke.
Updated 11/20/10
page 2
Curriculum Vitae: William Julian Pearce
AWARDS AND HONORARIA:
Young Scientist Award for paper presented at the 7th International Congress of Cerebral
Function, Metabolism, and Circulation, Copenhagen, Denmark, 7/77.
Young Scientist Award for paper presented at the 28th International Congress of Physiological
Sciences, Budapest, Hungary, 7/80.
Young Scientist Honorarium for paper presented at the 2nd International Symposium of
Neurogenic Control of CBF, Iowa City, IA, 6/81.
Honorarium for lecture delivered to the Department of Physiology, University of Bonn, Bonn,
West Germany, 3/88.
Honorarium for lecture delivered to the NICHHD conference on Vasoactive Substances in
Perinatal Research held in Alexandria, VA, 9/91.
Honorarium for lecture delivered to the Department of Physiology and Pharmacology, Bowman
Gray School of Medicine, Winston-Salem, NC, 1/92.
Honorarium for lecture delivered to the Totman Conference on the Human Cerebral Circulation,
held in Burlington, Vermont, 10/92
Honorarium for lecture delivered to the Department of Pharmacology and Toxicology, Albany
Medical School, Albany, NY, 10/92
Honorarium for lecture delivered to the Department of Physiology and Biophysics, University of
Tennessee, Memphis, Tennessee, 3/94
Honorarium for lecture delivered to the Lawson Research Institute, University of Western
Ontario, London, Ontario, 11/96
Elected Fellow, Cardiovascular Section of American Physiological Society, 4/99
Honorarium for lecture delivered to the Department of Pharmacology, University of Nevada at
Reno, 8/99
Honorarium for lectures delivered to the Department of Neurosurgery, and the Department of
Physiology, University of Mississippi at Jackson, 2/01
Visiting Professor Honorarium from the Center for Neurobiology, Cornell Medical School, 2/05
Visiting Professor Honorarium from the Department of Physiology, South Alabama School of
Medicine, September, 2005.
Visiting Professor Honorarium, School of Medicine, Souzhou University, Souzhou, China, 2006.
GRANTS AWARDED (Total Direct: $4,998,285):
Project Title:
“Regulation of the cerebral circulation”
Sponsor:
Macpherson Laboratory Research Fund, White Memorial Medical Center
Dates:
1/83 - 12/87
Amount:
$26,367
Project Title:
“The effects of diltiazem on the cerebral circulation”
Sponsor:
American Heart Association, Greater Los Angeles Affiliate
Dates:
7/83 - 6/84
Amount:
$6,604
Project Title:
“Cephalexin in recurrent urinary tract infections”
Sponsor:
Hoffman La Roche Pharmaceuticals
Dates:
8/83 - 7/84
Amount:
$6,900
Project Title:
“Hypoxic relaxation of isolated cerebral arteries”
Sponsor:
Loma Linda University Basic Science Research Fund
Dates:
7/84 - 6/85
Amount:
$5,762
Project Title:
“Direct effects of hypoxia on immature cerebral arteries”
Sponsor:
Loma Linda University School of Medicine
Dates:
1/85 - 12/86
Amount:
$24,848
Updated 11/20/10
page 3
Curriculum Vitae: William Julian Pearce
GRANTS AWARDED (con’d)):
Project Title:
“Direct effects of hypoxia on isolated cerebral arteries”
Sponsor:
American Heart Association, Greater Los Angeles Affiliate
Dates:
7/85 - 6/86
Amount:
$11,826
Project Title:
“The effects of extracellular calcium on hypoxic relaxation of isolated newborn
lamb and adult sheep cerebral arteries.”
Sponsor:
Pediatric Research Fund, Loma Linda University
Dates:
1/86 - 12/86
Amount:
$9,000
Project Title:
“Regulation of hypoxic relaxation in fetal, newborn and adult arteries”
Sponsor:
Loma Linda University Basic Science Research Fund
Dates:
1/87 - 12/87
Amount:
$12,200
Project Title:
“Direct effects of hypoxia on isolated cerebral arteries: role of the endothelium”
Sponsor:
American Heart Association, Greater Los Angeles Affiliate
Dates:
7/87 - 6/88
Amount:
$17,051
Project Title:
TA-3090 and cerebral autoregulation
Sponsor:
Marion Laboratories
Dates:
10/87 - 9/88
Amount:
$8,400
Project Title:
“Mechanisms of hypoxic cerebral vasodilation in newborns”
Sponsor:
National Institutes of Health
Dates:
7/88 - 6/93
Amount:
$383,178 (direct)
Project Title:
“Effects of hypoxia on calcium uptake in lamb cerebral arteries”
Sponsor:
Loma Linda University Seed Money Fund
Dates:
1/89 - 12/89
Amount:
$9,000
Project Title:
“Cerebrovascular Adaptations to long term hypoxia”
Sponsor:
American Heart Association
Dates:
7/90 - 6/92
Amount:
$49,720
Project Title:
“Mechanisms of Hypoxic Cerebral Vasodilatation in Fetal, Newborn, and Adult
Sheep”
Sponsor:
National Institutes of Health: BSRG
Dates:
4/91 - 3/92
Amount:
$6,334
Project Title:
“Mechanisms of Hypoxic Cerebral Vasodilatation in Fetal, Newborn, and Adult
Sheep”
Sponsor:
National Institutes of Health: BSRG
Dates:
4/92 - 3/93
Amount:
$8,940 (direct)
Project Title:
“Cerebrovascular Adaptations to Long-Term Hypoxia”
Sponsor:
American Heart Association
Dates:
7/92 - 6/94
Amount:
$99,858 (direct)
Project Title:
“Effects of maturation on hypoxic hyperpolarization in cerebral arteries”
Sponsor:
Society for Pediatric Research
Dates:
9/93 - 8/94
Amount:
$9,000
Updated 11/20/10
page 4
Curriculum Vitae: William Julian Pearce
GRANTS AWARDED (con’d)):
Project Title:
“Physiological Modulation of Pharmacomechanical Coupling in Ovine Cerebral
Arteries”
Sponsor:
National Institutes of Health
Dates:
3/95 - 11/99
Amount:
$545,000 (direct)
Project Title:
“Maturation of Cerebrovascular Contractile Mechanisms”
Sponsor:
National Institutes of Health
Dates:
4/95 - 3/98
Amount:
$257,000 (direct)
Project Title:
“Maturation of Cerebrovascular Contractile Mechanisms” (Renewal)
Sponsor:
National Institutes of Health
Dates:
4/98 - 3/02
Amount:
$451,087 (direct)
Project Title:
“Physiological Modulation of Endothelial Vasodilator Function in Ovine
Cerebral Arteries”
Sponsor:
National Institutes of Health
Dates:
1/00 – 12/04
Amount:
$695, 833 (direct)
Project Title:
“Maturation of Cerebrovascular Relaxant Mechanisms”
Sponsor:
National Institutes of Health
Dates:
8/00 – 7/04
Amount:
$500,000 (direct)
Project Title:
“Maturation of Cerebrovascular Contractile Mechanisms” (Renewal)
Sponsor:
National Institutes of Health
Dates:
5/02 - 4/06
Amount:
$500,000 (direct)
Project Title:
“Fetal and Neonatal Cerebral Physiology” (R13 Conference Grant)
Sponsor:
National Institutes of Health
Dates:
07/03
Amount:
$9,802 (direct)
Project Title:
“Hypoxic modulation of Protein Kinase G function in fetal and adult sheep
cerebral arteries”
Sponsor:
National Institutes of Health
Dates:
1/1/05 – 12/31/09
Amount:
$859,318 (direct)
Project Title:
“Maturation of cerebrovascular relaxant mechanisms”
Sponsor:
National Institutes of Health
Dates:
2/1/06 – 1/31/10
Amount:
$600,000 (direct)
Project Title:
“The role of Vascular Endothelial Growth Factor in hypoxic remodeling of
ovine cerebral arteries
Sponsor:
National Institutes of Health
Dates:
8/1/10 – 7/31/15
Amount:
$744,575 (direct)
Updated 11/20/10
page 5
Curriculum Vitae: William Julian Pearce
PEER-REVIEWED PUBLICATIONS:
1. Pearce, W.J. and D'Alecy, L.G. (1980) Hemorrhage-induced cerebral vasoconstriction in dogs.
Stroke 11: 190-197.
2. Bevan, J.A., Bevan, R.D., Florence, V.W., McCalden, T.A., Pearce, W.J., Rowan, R.A.,
Winquist, R.S. (1981) Specialization in cerebral and extracerebral neurovascular
mechanisms. Federation Proceedings 40: 2301-2305.
3. Pearce, W.J., Scremin, O.U., Sonnenschein, R.R., Rubinstein, E.H. (1981) EEG, blood flow,
and oxygen uptake in the rabbit cerebrum. Journal of Cerebral Blood Flow and
Metabolism 1: 419-428.
4. Pearce, W.J., Bevan, J.A. (1984) Retroglenoid venoconstriction and its influence on canine
intracranial pressures. Journal of Cerebral Blood Flow and Metabolism 4: 373-380.
5. Thompson, D., Pearce, W.J., Longerbeam, J. (1985) Analytical diagnostic peritoneal lavage
in the diagnosis of intra-abdominal injury. Journal of Trauma 25: 400.
6. Berman, M. and Pearce, W.J. (1986) The use of Gore-Tex EPTFE bonded to silicone rubber
as an alloplastic implant material. Laryngoscope 96: 480-483.
7. Pearce, W.J. and Ashwal, S. (1987) Developmental changes in thickness, contractility, and
hypoxic sensitivity of newborn lamb cerebral arteries. Pediatric Research 22: 192-196.
8. Pearce, W.J., Bevan, J.A. (1987) Diltiazem and autoregulation of canine cerebral blood flow.
Journal of Pharmacology and Experimental Therapeutics 242(3): 812-817.
9. Pearce,W.J., Ashwal, S., Cuevas, J. (1989) Direct effects of graded hypoxia on intact and
denuded rabbit cranial arteries. American Journal of Physiology 257: H824-H833.
10. Gilbert, R.D.,Pearce, W.J.,Ashwal, S.,Longo, L.D. (1990) Effects of hypoxia on contractility
of isolated fetal lamb cerebral arteries. Journal of Developmental Physiology 13:199-203.
11.Pearce, W.J.,Reynier-Rebuffel, A.M.,Lee, J.,Aubineau, P.,Ignarro, L.,Seylaz, J. (1990)
Effects of methylene blue on hypoxic cerebral vasodilatation in the rabbit. Journal of
Pharmacology and Experimental Therapeutics 254:616-625.
12. Pearce, W.J., Longo, L.D. (1991) Developmental aspects of endothelial function. Seminars
in Perinatology 15:40-48.
13. Longo, L.D., Pearce, W.J. (1991) Fetal and newborn cerebral vascular responses and
adaptations to hypoxia. Seminars in Perinatology 15:49-57.
14. Pearce, W.J.,Hull, A.D.,Long, D.M.,Longo, L. (1991) Developmental changes in ovine
cerebral artery composition and reactivity. American Journal of Physiology 261: R458R465.
15. Hodgkin, D.D.,Boucek, R.J.,Purdy, R.E.,Pearce, W.J.,Fraser, I.M.,Gilbert, R.D. (1991)
Dietary lipids modify receptor and non-receptor dependent components of alpha1adrenoceptor mediated contraction. American Journal of Physiology 261: R1465-R1469.
16. Pearce, W.J.,Ashwal, S.,Long, D.M.,Cuevas, J. (1992) Hypoxia inhibits calcium influx in
rabbit basilar and carotid arteries. American Journal of Physiology 262: H106-H113.
17. Hull, A.D.,Long, D.L.,Longo, L.D.,Pearce, W.J. (1992) Pregnancy-induced changes in
cerebrovascular composition and reactivity. American Journal of Physiology 262: R137R143.
18. Mraovitch, S., Calando, Y., Pinard, E., Pearce, W. J. , Seylaz, J. (1992) Differential
cerebrovascular and metabolic responses in specific neural systems elicited from the
centromedian-parafascicular complex. Neuroscience 49: 451-66.
19. Longo, L.D., Hull, A.D., Long, D.L., Pearce, W.J. (1993) Cerebrovascular adaptations to
high altitude hypoxemia in fetal and adult sheep. American Journal of Physiology 264:
R65-R72.
20. Hull, A.D., Longo, L.D., Long, D.M., Pearce, W.J. (1993) Pregnancy alters cerebrovascular
adaptation to high altitude hypoxia. American Journal of Physiology 266: R765-R772.
21. Ashwal, S., Cole, D.J., Osborne, T.N., Pearce, W.J. (1993) Low dose L-NAME reduces
infarct volume in the rat MCAO/reperfusion model. Journal of Neurosurgical
Anesthesiology 5: 241-249.
Updated 11/20/10
page 6
Curriculum Vitae: William Julian Pearce
PEER-REVIEWED PUBLICATIONS (con’d):
22. Pearce, W.J., Elliott, S.R. (1994) Maturation enhances the sensitivity of ovine cerebral
arteries to the ATP-sensitive potassium channel activator lemakalim. Pediatric Research
35: 729-732.
23. Ashwal, S., Cole, D.J., Osborne, T.N., Pearce, W.J. (1994) Dual effects of L-NAME during
transient focal cerebral ischemia in spontaneously hypertensive rats. American Journal of
Physiology 267:H276-H284.
24. Hull, A.D., White, C.R., Pearce, W.J. (1994) Endothelium-derived relaxing factor and cyclic
GMP-dependent vasorelaxation in human chorionic plate arteries. Placenta 15: 365-375.
25. Pearce, W.J., Hull, A.D., Long, D.M., White, C.R. (1994) Effects of maturation on cyclic
GMP-dependent vasodilatation in ovine basilar and carotid arteries. Pediatric Research 36:
25-33.
26. Elliott, S.R., Pearce, W.J. (1994) Effects of maturation on a-adrenergic receptor affinity and
occupancy in small cerebral arteries. American Journal of Physiology 267: H757-H763.
27. Pearce, W.J. (1995) Mechanisms of hypoxic cerebral vasodilatation. Pharmacology and
Therapeutics 65: 75-91.
28. Zhang, L., Pearce, W.J., Longo, L.D. (1995) Noradrenalin-mediated contractions of ovine
uterine artery: role of inositol 1,4,5-trisphosphate. European Journal of Pharmacology
(Mol Pharmacol) 289: 375-382.
29. Ashwal, S., Cole, D.J., Osborne, S., Osborne, T.N., Pearce, W.J. (1995) A new model of
neonatal stroke: reversible middle cerebral artery occlusion in the rat pup. Ped Neurol 12:
191-196.
30. Elliott, C.F., Pearce, W.J. (1995) Effects of maturation on cell water, protein and DNA
content in ovine cerebral arteries. Journal of Applied Physiology 79: 831-837
31. Zurcher,
S.D., Pearce, W.J. (1995) Maturation modulates serotonin- and potassium-induced
45
Ca uptake in ovine carotid and cerebral arteries. Pediatric Research 38: 493-500.
32. Ashwal, S., Cole, D.J., Osborne, T.N., Osborne, S., Pearce, W.J. (1995) L-NAME reduces
infarct volume in a filament model of transient middle cerebral artery occlusion in the rat
pup. Pediatric Research 38: 652-656.
33. White, C.R., Pearce, W.J. (1996) Effects of maturation on cyclic GMP metabolism in ovine
carotid arteries. Pediatric Research 39: 25-31.
34. Longo, L.D., Ueno, N., Zhao, Y., Zhang, L., Pearce, W.J. (1996) NE-induced contraction,
1-adrenergic receptors, and Ins(1,4,5)P3 responses in cerebral arteries. American Journal
of Physiology 270: H915-H923.
35. Rhee, J.W., Longo, L.D., Pearce, W.J., Bae, N.H., Valenzuela, G.G., Ducsay, C.A. (1996)
Effect of chronic hypoxia on myometrial responsiveness in the pregnant rat. American
Journal of Physiology 270: E477-E482.
36. Longo, L.D., Ueno, N., Zhao, Y., Pearce, W.J., Zhang, L. (1996) Developmental changes in
1-adrenergic receptors, IP3 responses, and NE-induced contraction in cerebral arteries.
American Journal of Physiology 271:H2313-H2319.
37. Akopov, S.E., Zhang, L., Pearce, W.J. (1997) Intracranial-extracranial differences in the
Ca2+ sensitivity of rabbit arteries. Proceedings of the Society for Experimental Biology
and Medicine 214: 76-82.
38. Akopov, S.E., Zhang, L., Pearce, W.J. (1997) Physiological variations in ovine
cerebrovascular calcium sensitivity. American Journal of Physiology 272: H2271-H2281.
39. Browne, V.A., Stiffel, V.M., Pearce, W.J., Longo, L.D., Gilbert, R.D. (1997) Activator
calcium and myocardial contractility in fetal sheep exposed to long-term high-altitude
hypoxia. American Journal of Physiology 272: H1196-H1204.
40. Pearce, W.J., Tone, B., Ashwal, S. (1997) Maturation alters cerebral NOS kinetics in the
spontaneously hypertensive rat. American Journal of Physiology 273: R1367-1373.
41. Akopov, S.E., Zhang, L., Pearce, W.J. (1997) Mechanisms of platelet-induced angiospastic
reactions: potentiation of calcium sensitivity. Canadian Journal of Physiology and
Pharmacology 75: 849-852.
Updated 11/20/10
page 7
Curriculum Vitae: William Julian Pearce
PEER-REVIEWED PUBLICATIONS (con’d):
42. Browne, V.A., Stiffel, V.M., Pearce, W.J., Longo, L.D., Gilbert, R.D. (1997) Cardiac adrenergic receptor function in fetal sheep exposed to long-term high-altitude hypoxia.
American Journal of Physiology 273: R2022-R2031.
43. Ashwal, S., Tone, B., Tian, H.R., Cole, D.J., Pearce, W.J. (1998) Core and penumbral nitric
oxide synthase activity during cerebral ischemia and reperfusion. Stroke 29: 1037-1047.
44. Longo, L.D., Pearce, W.J. (1998) High altitude, hypoxic-induced modulation of
noradrenergic-mediated responses in fetal and adult cerebral arteries. Comp Biochem
Physiol 119A:683-694.
45. Akopov, S.E., Zhang, L., Pearce, W.J. (1998) Developmental changes in the calcium
sensitivity of rabbit cranial arteries. Biology of the Neonate 74: 60-71.
46. Zurcher, S.D., Ong-Veloso, G.L., Akopov, S.E., Pearce, W.J. (1998) Maturational
modification of hypoxic relaxation in ovine carotid and cerebral arteries: role of
endothelium. Biology of the Neonate 74: 222-232
47. Akopov, S.E., Zhang, L., Pearce, W.J. (1998) Maturation alters the role of calcium in ovine
basilar arteries. Pediatric Research 44: 154-160.
48. Teng, G.Q., Williams, J.M., Zhang, L., Purdy, R., Pearce, W.J. (1998) Effects of maturation,
artery size, and chronic hypoxia on 5HT receptor type in ovine cranial arteries. American
Journal of Physiology 275: R742-R753
49. Akopov, S.E., Zhang, L., Pearce, W.J. (1998) Regulation of Ca2+ sensitization by PKC and
Rho proteins in ovine cerebral arteries: effects of artery size and age. American Journal of
Physiology 275: H930-H939.
50. Pearce, W.J. (1998) Effects of ischemia on cerebral arteriolar dilation to arterial hypoxia in
piglets (Editorial). Stroke 29: 227-228.
51. Pearce, W.J. (1998) High levels of myogenic tone antagonize the dilator response to flow in
small rabbit cerebral arteries (Editorial). Stroke 29: 1200-1201.
52. Pearce, W.J. (1998) Embolic events worsen secondary ischemic outcome (Editorial). Stroke
30, 862.
53. Hu, X.Q., Yang, S., Pearce, W.J., Longo, L.D., Zhang, L (1999) Effect of chronic hypoxia on
alpha-1 adrenoceptor-mediated inositol 1,4,5-trisphosphate signaling in ovine uterine
artery. Journal of Pharmacology and Experimental Therapeutics 288: 977-983.
54. Xiao, D., Liu, Y., Pearce, W. J., Zhang, L. (1999) Endothelial nitric oxide release in isolated
perfused ovine uterine arteries: effect of pregnancy. European Journal of Pharmacology
367:223-230.
55. Ashwal, S., Tone, B., Tian, H.R., Cole, D.J., Liwnicz, B.H., Pearce, W.J. (1999) Core and
penumbral nitric oxide synthase activity during cerebral ischemia and reperfusion in the rat
pup. Pediatric Research 46: 390-400.
56. Pearce, W.J., Duckles, S.P., Buchholz, J. (1999) Effects of maturation on adrenergic
neurotransmission in ovine cerebral arteries. American Journal of Physiology 277: R931R937.
57. Pearce, W.J. (1999) Cerebral blood flow during hemodilution and hypoxia in rats: role of
ATP-sensitive potassium channels (Editorial). Stroke 30:1947-1948.
58. White, C.R., Hao, X., Pearce, W.J. (2000) Maturational differences in soluble guanylate
cyclase activity in ovine carotid and cerebral arteries. Pediatric Research 47: 369-375.
59. Garcia, F.C., Stiffel, V.M., Pearce, W.J., Zhang, L., Gilbert, R.D. (2000) Ca2+ sensitivity of
fetal coronary arteries exposed to long-term, high altitude hypoxia. J Soc Gynecol Investig
7:161-6.
60. Angeles, D.M., Williams, J., Zhang, L., Pearce, W.J. (2000) Acute hypoxia selectively
modulates 5HT receptor density and agonist affinity in fetal and adult ovine carotid
arteries. American Journal of Physiology 279: H502-H510.
61. Nauli, S.M., Zhang, L., Pearce, W.J. (2001) Maturation depresses cGMP-mediated decreases
in [Ca2+]i and Ca2+ sensitivity in ovine cranial arteries. American Journal of Physiology
280:H1019-H1028.
Updated 11/20/10
page 8
Curriculum Vitae: William Julian Pearce
PEER-REVIEWED PUBLICATIONS (con’d):
62. Angeles, D.M., Williams, J., Purdy, R., Zhang, L., Pearce, W.J. (2000) Effects of maturation
and acute hypoxia on receptor-IP3 coupling in ovine common carotid arteries. American
Journal of Physiology 280:R410-R417.
63. Xiao, D., Pearce, W.J., Zhang, L. (2001) Pregnancy enhances endothelium-dependent
relaxation of ovine uterine artery: role of NO and intracellular Ca2+. American Journal of
Physiology 281:H183-90.
64. Nauli, S.M., Williams, J.M., Pearce, W.J. (2001) Effects of maturation on mechanisms of
cGMP-induced cerebral vasodilatation. Developmental Neuroscience 23:224-233.
65. Nauli, S.M., Williams, J.M., Akopov, S.E., Zhang, L., Pearce, W.J. (2001) Developmental
changes in ryanodine- and IP3-sensitive Ca2+ pools in the ovine basilar artery. American
Journal of Physiology, Cell Physiology 281:C1785-1796.
66. Nauli, S.M., Ally, A., Zhang, L., Gerthoffer, W.T., Pearce, W.J. (2000) Maturation
attenuates the effects of cGMP on contraction, [Ca2+]i and Ca2+ sensitivity in ovine
basilar arteries. General Pharmacology: The Vascular System 35: 107-118.
67. Ishide, T, Maher, T., Nauli S.M., Pearce, W.J., Ally, A., (2001) Modulation of pressor
response to muscle contraction via monoamines following AMPA-receptor blockade in the
ventrolateral medulla . Pharm Res 44:481-489.
68. Nauli, S.M., Pearce, W.J., Amer, A., Maher, T.J., and Ally, A. (2001) Effects of nitric oxide
and GABA interaction within ventrolateral medulla on cardiovascular responses during
static muscle contraction. Brain Res 922:234-242.
69. Ishide, T., Pearce, W.J., Nauli, S.M., Chaiyakul, P., Maher, T.J., Ally, A. (2001)
Simultaneous glutamate and g-aminobutyric acid release within ventrolateral medulla
during skeletal muscle contraction in intact and barodenervated rats. Brain Research
923:137-46.
70. Ashwal, S., Pearce, W.J. (2001) Animal models of neonatal stroke. Curr Opin Pediatr
13:506-511.
71. Nauli, S.M., Maher, T.J., Pearce, W.J., and Ally, A. (2001) Effects of opioid receptor
activation on cardiovascular responses and extracellular monoamines within the rostral
ventrolateral medulla during static contraction of skeletal muscle. Neuroscience Res
41:373-383.
72. Teng G.Q., Nauli, S.N., Brayden, J.E., Pearce, W.J. (2002) Maturation alters the
contribution of potassium channels to resting and 5HT-induced tone in small cerebral
arteries of the sheep. Brain Res Dev Brain Res 133:81-91.
73. Ishide, T., Pearce, W.J., Ally, A. (2002) Cardiovascular responses during stimulation of
hindlimb skeletal muscle nerves in anesthetized rats. Clin Exp Pharmacol Physiol 29: 689695.
74. Krause, D.N., Purdy, R.E., Pearce, W.J., Duckles, S.P. (2002) Vascular neuroeffector
mechanisms: the next 30 years. Trends Pharmacol Sci 23:541-2.
75. Nauli, S.M., White, C.R., Hull, A.D., and Pearce, W.J. (2003) Maturation alters cyclic
nucleotide crosstalk and relaxation responses to NO donors in ovine cerebral arteries.
Biology of the Neonate 83: 125-135.
76. Geary, G.G., Buchholz, J.N., Pearce WJ (2003) Maturation depresses mouse cerebrovascular
tone through endothelium-dependent mechanisms. American Journal of Physiology 284:
R743-R741.
77. Mbaku, E.M., Zhang, L., Pearce, W.J., Duckles, S.P., and Buchholz, J. (2003) High altitude
chronic hypoxia alters the function of NOS neuron endings in cerebral arteries of near-term
fetal and adult sheep. Journal of Applied Physiology 94: 724-32.
78. Xiao, D., Huang, X., Pearce, W.J., Longo, L.D., Zhang, L. (2003) Effect of Cortisol on
norepinephrine-mediated contractions in ovine uterine arteries. American Journal of
Physiology 284: H1142-H2252.
79. Pearce, W.J., Williams, J.M., Chang, M.M., and Gerthoffer, W.T. (2003) ERK inhibition
attenuates 5-HT-induced contractions in fetal and adult ovine carotid arteries. Archives
and Physiology and Biochemistry 111: 36-44.
Updated 11/20/10
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Curriculum Vitae: William Julian Pearce
PEER-REVIEWED PUBLICATIONS (con’d):
80. Hunter, C.J., Blood, A.B., White, C.R., Pearce, W.J., Power, G.G. (2003) Role of nitric oxide
in hypoxic cerebral vasodilatation in the ovine fetus. Journal of Physiology (London)
81549:625-33.
81. Gilbert, R.D., Pearce, W.J., and Longo, L.D. (2003) Fetal Cardiac and Cerebrovascular
Acclimatization Responses to High Altitude, Long-term Hypoxia. High Alt Med Biol
4:203-13.
82. Lin, M.T., Hessinger, D.A., Pearce, W.J., Longo, L.D. (2003) Developmental Differences in
Ca2+-Activated K+ (BKCa) Channel Activity in Ovine Basilar Artery. American Journal
of Physiology 285:H701-H709.
83. Xiao, D., Pearce, W.J., Longo, L. D., Zhang, L. (2004) ERK-mediated uterine artery
contraction: role of thick and thin filament regulatory pathways. American Journal of
Physiology 286: H1615-H1622.
84. Zhao., Y, Xiao, H., Long, W., Pearce, W.J., Longo, L.D. (2004) Expression of several
cytoskeletal proteins in cerebral arteries: Developmental and Functional Considerations. J
Physiol 558: 623-632.
85. Williams, J.M., Hull, A.D., Pearce, W.J. (2005) Maturational modulation of endotheliumdependent vasodilatation in ovine cerebral arteries. American Journal of Physiology 288:
R149-57
86. Longo, L.D., Pearce, W.J. (2005) Fetal cerebrovascular acclimatization responses to high
altitude, long-term hypoxia: A model for prenatal programming of adult disease?
American Journal of Physiology 288:R16-24
87. Nauli, S.M., Williams, J.M., Gerthoffer, W.T., Pearce. W.J. (2005) Chronic Hypoxia
Modulates Relations Among Calcium, Myosin Light Chain Phosphorylation, and Force
Differently in Fetal and Adult Ovine Basilar Arteries. Journal of Applied Physiology 99:
120-127.
88. Angeles, D.M., Wycliffe, N. Holshouser, B.A., Deming, D., Pearce, W.J., Sowers, L.C.,
Ashwal, S. (2005) Use of Opioids in Asphyxiated Term Neonates: Effects on
Neuroimaging and Clinical Outcome. Pediatric Research 57: 873-878.
89. Lin, M.T., Longo, L.D., Pearce, W.J., Hessinger, D.A. (2005) Calcium-Activated K+ (BK)
Channel-Associated Phosphatase and Kinase Activities during Development. Am J Physiol
Heart Circ Physiol 289:H414-25.
90. White, C.R., Hamade, M.W., Siami, K., Chang, M.M., Mangalwadi1, A., Frangos, J.A.,
Pearce, W.J. (2005) Maturation Enhances Fluid Shear-Induced Activation of eNOS in
Perfused Ovine Carotids. American Journal of Physiology, Heart Section 289:H2220-2227.
91. Vanterpool, C.K., Pearce, W.J., Buchholz, J.N. (2005) Advancing age alters rapid and
spontaneous refilling of caffeine sensitive calcium stores in sympathetic superior cervical
ganglion cells. Journal of Applied Physiology 99:963-971.
92. Angeles, D.M., Chang, M., Leong, V., Oberg, K.C., Pearce, W.J. (2005) Dexamethasone
alters vascular reactivity by enhancing COX-related vasodilatationo in fetal ovine carotids.
Biol Neonate 90:1-8.
93. Williams, J.M., Pearce, W.J. (2006) Age-dependent modulation of endothelium-dependent
vasodilatation by chronic hypoxia in ovine cranial arteries. Journal of Applied Physiology
100:225-232.
94. Pearce, W. J. (2006) Hypoxic regulation of the fetal cerebral circulation. Journal of Applied
Physiology 100: 731-738.
95. Williams, J.M., White, C.R., Chang, M.M., Injeti, E.R., Zhang, L., Pearce, W.J. (2006)
Chronic hypoxic decreases in soluble guanylate cyclase protein and enzyme activity are
age-dependent in fetal and adult ovine carotid arteries. Journal of Applied Physiology 100:
1857-66.
96. Xiao, D., Huang, X., Longo, L.D., Pearce, W.J., Zhang, L. (2006) Regulation of baseline
Ca2+ sensitivity in permeabilized uterine arteries: effect of pregnancy. American Journal
of Physiology 291:H413-420.
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Curriculum Vitae: William Julian Pearce
PEER-REVIEWED PUBLICATIONS (con’d):
97. Pearce, W.J. (2006) Basic and Translational Neonatal Neuroscience Research: Whither goest
the future of Physician-Scientists? Journal of Perinatology 26 Suppl 2:S23-29.
98. Vanterpool, C.K., Vanterpool, E.A., Pearce, W.J., Buchholz, J.N. (2006) Advancing age
alters the expression of the ryanodine receptor 3 isoform in adult rat superior cervical
ganglia. Journal of Applied Physiology 101:392-400.
99. Lin, M.T., Hessinger, D.A., Pearce, W.J., Longo, L.D. (2006) Modulation of BK channel
calcium affinity by differential phosphorylation in developing ovine basilar artery
myocytes. American Journal of Physiology 291:H732-740.
100. Pearce, W.J., Williams, J.M., Hamade, M.W., Chang, M.M., White, C.R. (2006) Chronic
Hypoxia Modulates Endothelium-Dependent Vasorelaxation Through Multiple
Independent Mechanisms in Ovine Cranial Arteries. Advances in Experimental Medicine
and Biology 578:87-92.
101. Angeles, D.M., Pearce, W.J. (2006) Effect of dopamine on vascular reactivity in near-term
lamb carotids: role of the endothelium. Biological Research for Nursing 8:97-103.
102. Nishida, N., Blood, A.B., Hunter, C.J., Bragg, S., Williams, J., Pearce, W.J., Power, G.G.
(2006) Role of prostanoids in the regulation of cerebral blood flow during normoxia and
hypoxia in the fetal sheep. Pediatric Research 60:524-9.
103. Buchholz, JN., Behringer, EJ., Pottorf, WJ., Pearce, WJ., and Vanterpool, CK. (2007) Agedependent changes in Ca2+ homeostasis in peripheral neurones: implications for changes
in function. Aging Cell 6: 285-296.
104. Sandoval RJ, Injeti ER, Williams JM, Georthoffer WT, and Pearce WJ. (2007) Myogenic
contractility is more dependent on myofilament calcium sensitization in term fetal than
adult ovine cerebral arteries. Am J Physiol Heart Circ Physiol 293: H548-556.
105. Pearce WJ. (2007) Cerebrovascular effects of ischemic preconditioning: endothelial
survivin joins the fray. Am J Physiol Heart Circ Physiol 292: H2559-2560.
106. Charles SM, Zhang L, Longo LD, Buchholz JN, Pearce WJ. (2007) Postnatal maturation
attenuates pressure-evoked myogenic tone and stretch-induced increases in Ca2+ in rat
cerebral arteries. Am J Physiol Regul Integr Comp Physiol 293:R737-44.
107. Sandoval RJ, Injetti ER, Gerthoffer WT, Pearce WJ. (2007) Postnatal maturation modulates
relations among cytosolic Ca2+, myosin light chain phosphorylation, and contractile tone
in ovine cerebral arteries. Am J Physiol Heart Circ Physiol 293:H2183-92.
108. Nauli SM, Kawanabe Y, Kaminski JJ, Pearce WJ, Ingber DE, Zhou J. (2008) Endothelial
cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production
through polycystin-1. Circulation 117:1161-71.
109. Injeti ER, Sandoval RJ, Williams JM, Smolensky AV, Ford LE, Pearce WJ (2008) Maximal
stimulation-induced in situ myosin light chain kinase activity is greater in fetal than adult
ovine carotids. Am J Physiol Heart Circ Physiol 295: H2289-98.
110. Behringer EJ, Vanterpool CK, Pearce WJ, Wilson SM, and Buchholz JN (2009) Advancing
age alters the contribution of calcium release from smooth endoplasmic reticulum stores in
superior cervical ganglion cells. J Gerontology 64: 34-44.
111. Sakata N, Hayes P, Tan A, Chan N, Mace J, Peverini R, Sowers L, Pearce W, Chinnock R,
Obenaus A, Hathout E (2009) MRI Assessment of Ischemic Liver Following Intraportal
Islet Transplantation. Transplantation 87: 825-830.
112. Pearce WJ, Williams JM, White CR, Lincoln TM. (2009) Effects of chronic hypoxia on
soluble guanylate cyclase activity in fetal and adult ovine cerebral arteries. J Appl Physiol
107:192-199.
113. Pearce WJ. (2009) Multifunctional Angiogenic Factors: add GnRH to the list. Am J Physiol
Cell 297: C4-C5.
114. Hathout E, Chan NK, Tan A, Sakata N, Mace J, Pearce W, Peverini R, Chinnock R, Sowers
L, Obenaus A (2009) In vivo imaging demonstrates a time-line for new vessel formation in
islet transplantation. Pediatric Transplantation 13:892-7.
Updated 11/20/10
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Curriculum Vitae: William Julian Pearce
PEER-REVIEWED PUBLICATIONS (con’d):
115. Behringer EJ, Leite LD, Buchholz NE, Keeney MG, Pearce WJ, Vanterpool CK, Wilson
SM, Buchholz JN (2009) Maturation and long-term hypoxia alter calcium-induced calcium
release in sheep cerebrovascular sympathetic neurons. Journal of Applied Physiology
107:1223-34.
116. Khorram O, Han G, Bagherpour R, Magee TR, Desai M, Ross MG, Chaudhri AA,
Toloubeydokhti T, Pearce WJ (2010) Effect of maternal undernutrition on vascular
expression of micro and messenger RNA in newborn and aging offspring. American
Journal of Physiology: Regulatory, Integrative and Comparative Physiology 298:R1366-74.
PMID: 20200130.
117. Charles SM, Zhang L, Cipolla MJ, Buchholz JN, Pearce WJ (2010) The Roles of cytosolic
Ca2+ concentration and myofilament Ca2+ sensitization in age-dependent cerebrovascular
myogenic tone. American Journal of Physiology, Heart and Circulatory Physiology
299:H1034-44. PMID: 20639216).
118. Pearce WJ, Butler SM, Abrassart JM, Williams JM (2010) Fetal Cerebral Oxygenation: The
Homeostatic Role of Vascular Adaptations to Hypoxic Stress. Adv Exp Med Biol (in
press).
119. Butler SM, Abrassart JM, Hubbell MC, Adeoye O, Semotiuk AM, Williams JM, MataGreenwood E, Khorram O, Pearce WJ (2010) Contributions of VEGF to age-dependent
transmural gradients in contractile protein expression in ovine carotid arteries. American
Journal of Physiology, Cell Physiology (in press).
Updated 11/20/10
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Curriculum Vitae: William Julian Pearce
CHAPTERS:
1. Pearce, W.J. and Bevan, J.A. (1981) Sympathetic stimulation, cerebral blood flow and the
role of extra-cerebral vasoconstriction. In Advances in Physiological Sciences, Vol. IX:
Cardiovascular Physiology: Neural Control Mechanisms, A.G.B. Kovach, P. Sandor, M.
Kollai, eds. Pergamon Press, New York, pp. 269-278.
2. Pearce, W.J., Bevan R.D., Bevan, J.A. (1982) Neurogenic vasoconstriction of extracranial
veins draining canine cerebral venous effluent. In: Cerebral Blood Flow: Effects of Nerves
and Neurotransmitters, D.D. Heistad and M.L. Marcus, eds. Elsevier, North Holland,
pp.87-94.
3. Pearce, W.J. and Bevan, J.A. (1983) The influence of sympathetic extracranial
venoconstriction on canine cerebral venous, sigmoid sinus, and mean arterial pressures. In:
The Cerebral Veins, L.M. Auer and F. Loew, eds. Springer-Verlag Wien, New York, pp
239-247.
4. Pearce, W.J. (1986). Contactile characteristics of veins draining cerebral venous effluent in the
dog and monkey. In: Neural Regulation of Brain Circulation, C. Owman and J.E. Hardebo,
eds. Amsterdam, Elsevier Science Publishers B.V. (Biomedical Division), pp. 529-540.
5. Pearce, W.J. and Fisher, M. (1989) Basic mechanisms in stroke. In: Medical Therapy of
Acute Stroke, M. Fisher, ed. Marcel Dekker, New York, pp13-37.
6. Pearce, W.J. (1989) Hypoxic cerebral vasodilatation: an integration of direct and indirect
vascular effects of hypoxia. In: Neurotransmission and Cerebrovascular Function, Volume
II, J Seylaz and R. Sercombe, eds. Amsterdam, Elsevier Science Publishers B. V.
(Biomedical Division), pp 87-101.
7. Pearce, W.J. (1989) The roles of vascular endothelium, calcium uptake, and cyclic nucleotides
in hypoxic cerebral vasodilation". In: Neurotransmission and Cerebrovascular Function,
Volume I, J Seylaz and E.T. MacKenzie, eds. Amsterdam, Elsevier Science Publishers B.
V. (Biomedical Division) pp 97-100.
8. Pearce, W.J. (1990) Hypoxia promotes the release of both relaxing and contracting factors
from the endothelium of isolated cerebral arteries. In: Endothelium-Derived Contracting
Factors, G. Rubanyi and P. Vanhoutte, eds. Basel, Karger, pp. 20-31.
9. Pearce, W.J. (1993) Cerebrovascular Regulation During the Perinatal Period. In:
Developmental Physiology: A Pediatric Perspective, P Gluckman and M Heyman, eds.
Edward Arnold, LTD, Auckland, pp. 513-519.
10. Pearce, W.J. (1994) Cerebrovascular Regulation in the Fetus and Neonate. In: The
Regulation of Cerebral Blood Flow, J Phillis, eds. CRC Press, Boca Raton, pp 381-398.
11. Pearce, W.J. (1994) Mechanisms of hypoxic and hypercapnic cerebral vasodilatation. In:
The Human Brain Circulation; Functional Changes in Disease, J Bevan, R.D. Bevan, and
C.L. Walters, eds. Humana Press, Clifton, New Jersey. pp 195-210.
12. Pearce, W.J. (1995) Cerebrovascular development at altitude. In: Hypoxia and the Brain,
J.R. Sutton, C.S. Houston, G. Coates, eds. Queen City Printers, Burlington, pp 125-141.
13. Pearce, W.J., Harder, D.R. (1996) Cerebrovascular Smooth Muscle and Endothelium. In:
The Neurophysiological Basis of Cerebral Blood Flow Control, R Sercombe and S
Mraovitch, eds. John Libbey, LTD, London, pp 145-175.
14. Pearce, W.J. (1996) Chapter 30: Cerebrovascular Regulation. In: Pediatrics and
Perinatology: The Scientific Basis. P Gluckman and M Heyman, eds. Edward Arnold,
LTD, Auckland, pp 433-439.
19. Pearce, W.J., Williams, J.M., Teng, G.Q., Ball, K., White, C.R., Angeles, D., Zhang, L.,
Akopov, S.E. (2000) Maturation alters the role of calcium in cerebrovascular contractility.
In: Mechanisms of Cerebrovascular Function and Regulation, WJ Pearce and TJF Lee,
eds., Yen Foundation Press, Taipei, pp 311-330.
20. Pearce, W.J. (2002) Cerebrovascular Regulation in the Neonate. In: The Newborn BrainScientific Foundations and Clinical Applications. H Lagercrantz, M Hanson, P. Evrard, and
C. Rodeck, eds. Cambridge University Press, Cambridge, pp 252-277.
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Curriculum Vitae: William Julian Pearce
21. Pearce, W.J. (2002) Pharmacomechanical Coupling in the Cerebral Circulation. In: Cerebral
Blood Flow and Metabolism. L Edvinsson and D Krause, eds. Lippincott, Williams, and
Wilkins, Philadelphia, 99 88-106.
22. Pearce, W.J. (2002) Cytokines and the Cerebral Circulation. In: Cerebral Blood Flow and
Metabolism. L Edvinsson and D Krause, eds. Lippincott, Williams, and Wilkins,
Philadelphia, pp 362-368.
23. Pearce, W.J. and Nauli, S.M. (2002) Mechanisms of cGMP-induced cerebral vasodilatation:
contractile agonist and developmental age both make a difference. In: Brain Activation
and Cerebral Blood Flow Control. M. Tomita, Ed. Elsevier, Amsterdam, pp 379-393.
OTHER MANUSCRIPTS:
1. Pearce, W.J. and D'Alecy, L.G. (1977) Normotensive hemorrhage and cerebral blood flow.
Acta Neurol Scand 64: 44-45.
2. Pearce, W.J., Rubinstein, E.H., Scremin, D.U., Sonnenschein, R.R. (1981) The effects of EEG
desynchronization on blood flow and oxygen consumption in the rabbit brain. Journal of
Cerebral Blood Flow and Metabolism 1: S419-420.
3. Pearce, W.J., Bevan, J.A. (1981) The possible influence of extracerebral vasoconstriction on
cerebral hemodynamics. Journal of Cerebral Blood Flow and Metabolism 1(Suppl. 1):
325-326.
4. Pearce, W.J. and Bevan, J.A. (1983) The cerebrovascular selectivity of diltiazem. Journal of
Cerebral Blood Flow and Metabolism 3(Suppl. 1): S546-547.
5. Pearce, W.J. (1985) A comparison of the time courses and efficacies of action of verapamil,
diltiazem, and nimodipine on the canine cerebral circulation. Journal of Cerebral Blood
Flow and Metabolism 5(Suppl 1): S475-S476.
6. Pearce, W.J., Ashwal, S., Longo, L.D. (1985) The role of membrane hyperpolarization in the
direct effects of hypoxia on isolated cerebral arteries. Proceedings of the Western
Pharmacological Society 28: 131-134.
7. Pearce, W.J. and Ashwal, S. (1986) Mechanisms of hypoxic relaxation in isolated cerebral
arteries: The effects of extracellular calcium concentration. Proceedings of the Western
Pharmacological Society 29: 199-202.
8. Ashwal, S., Pearce, W.J., Ignarro, L.J. (1988) Hypoxia increases cyclic GMP in rabbit cranial
arteries. Proceedings of the Western Pharmacological Society 30: 125-128.
9. Pearce, W.J. (1989) Role of endothelial relaxing and contracting factors in rabbit cranial
artery responses to hypoxia. Proceedings of the Western Pharmacological Society 32: 239245.
10. Hull, A.D., Long, D.M., Longo, L.D., Pearce, W.J. (1991) Chronic Hypoxia Alters Ovine
Cerebrovascular Reactivity and Composition. Proceedings of the Western
Pharmacological Society 34: 233-238.
11. Hull, A.D., Long, D.M., Longo, L.D., Pearce, W.J. (1991) Pregnancy-induced changes in
ovine cerebrovascular reactivity and composition. Proceedings of the Western
Pharmacological Society 34: 239-245.
12. Pearce, W.J., Hull, A.D., Long, D.M., Longo, L.D. (1991) Effects of maturation on ovine
cerebrovascular endothelial function. Proceedings of the Western Pharmacological Society
34: 247-254.
13. Zurcher, S.D., Pearce, W.J. (1993) Maturation and hypoxia influence the calcium doseresponse relationship in ovine cerebral arteries. Proceedings of the Western
Pharmacological Society 36: 71-75.
14. Elliott, S.R., Pearce, W.J. (1993) Developmental contractility changes in ovine peripheral
cerebral arteries. Proceedings of the Western Pharmacological Society 36: 63-70.
15. Pearce, W.J., White, C.R. (1995) Determination of the [cGMP] yielding half-maximal
activation of G-kinase in intact ovine basilar arteries. Proceedings of the Western
Pharmacological Society 38: 55-58.
16. Longo, L.D., Pearce, W.J. (1996) High altitude, hypoxemic-induced changes in adrenergicmediated responses in fetal and adult cerebral arteries. Acta Andina 2: 62.
17. Pearce, W.J. (2010) Citations: Too Many, or Not Enough? The Scientist 24(8): 29.
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Curriculum Vitae: William Julian Pearce
BOOKS:
1. Pearce, Q.L., and Pearce, W.J. (1988) Search and Discover: My body and how it works. Tor
Books, New York, 48 pages.
2. Pearce, Q.L., and Pearce, W.J. (1988) Science Flash Cards: Fascinating Fun and Fact: The
Human Body. Watermills Press, Mahwah, New Jersey, 16 pages.
3. Pearce, Q.L., and Pearce, W.J. (1990) How and Why: Famous Science Experiments. Price,
Stern &Sloan, Los Angeles, 32 pages..
4. Pearce, Q.L., and Pearce, W.J. (1990) Natures Footprints: The Farm. Prentis Hall, New York,
24 pages.
5. Pearce, Q.L., and Pearce, W.J. (1990) Natures Footprints: The Forest. Prentis Hall, New
York, 24 pages.
6. Pearce, Q.L., and Pearce, W.J. (1990) Natures Footprints: The Grasslands. Prentis Hall, New
York, 24 pages.
7. Pearce, Q.L., and Pearce, W.J. (1990) Natures Footprints: The Desert. Prentis Hall, New
York, 24 pages.
8. Lee, T.J., and Pearce, W.J. (2000) Mechanisms of Cerebrovascular Function and Regulation.
Yen Foundation Press, Taipei, 356 pages.
Updated 11/20/10
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Curriculum Vitae: William Julian Pearce
INVITED LECTURES AND SEMINARS:
1. “The possible influence of extracerebral venoconstriction on cerebral hemodynamics in canine
and monkey.” Delivered at the international symposium entitled Cerebral Blood Flow:
Effect on Nerves and Neurotransmitters, held in Iowa City, Iowa, June, 1981.
2. “Intracranial pressure control: The role of extracranial venoconstriction.” Delivered at the 1st
International Symposium on Cerebral Veins, held in Graz, Austria, September, 1982,
3. “Contractile characteristics of veins draining cerebral venous effluent in the dog and monkey.”
Delivered at the international symposium entitled Neural Regulation of Brain Circulation
held in Lund, Sweden, June, 1985.
4. “On the direct effects of hypoxia on isolated cerebral arteries.” Delivered to the Laboratory of
Cerebrovascular Physiology and Pathophysiology, University of Paris VII, Paris, France,
December, 1987.
5. “Mechanisms of hypoxic cerebral vasodilatation." Delivered to the Department of
Physiology, University of Bonn, Bonn, West Germany, March, 1988.
6. "Hypoxia promotes the release of both relaxing and contracting factors from the endothelium
of isolated cerebral arteries." Delivered at the First International Symposium on
Endothelium-Derived Vasoactive Factors held in Philadelphia, Pennsylvania, May, 1989.
7. "The roles of vascular endothelium, calcium uptake, and cyclic nucleotides in hypoxic
cerebral vasodilatation." Delivered at the International Symposium on Neurotransmission
and Cerebrovascular Function held in La Napoule, France, June, 1989.
8. "Vascular mechanisms of hypoxic cerebral vasodilation." Delivered to the Department of
Pharmacology, University of Vermont, Burlington, Vermont, October, 1989.
9. "Developmental aspects of endothelial function." Delivered at the NICHHD conference
entitled "Endothelium-Derived Vasoactive Substances in Perinatal Research" held in
Alexandria, Virginia, September, 1990.
10. "Cerebrovascular adaptations to high altitude in fetal and adult sheep." Delivered to the
Department of Physiology and Pharmacology, Bowman Gray School of Medicine,
Winston-Salem, North Carolina, January, 1992.
11. "Cerebrovascular consequences of maturation." Delivered to the Department of Physiology
and Biophysics, University of Tennessee, Memphis, Tennesee, March, 1994.
12. “Cerebrovascular development at altitude.” Delivered at the 9th International Hypoxia
Symposium at Lake Lousie, Alberta, Canada, February, 1995.
13. “Combined effects of maturation and chronic hypoxia on serotonergic signal transduction in
ovine carotid arteries.” Delivered at the 23rd annual meeting of the Fetal and Neonatal
Physiological Society in Arica, Chile, August, 1996.
14. “Effects of maturation on serotonergic signal transduction in ovine carotid arteries.”
Delivered to the Lawson Research Institute, University of Western Ontario, in London,
Ontario, November, 1996.
15. “Signal transduction and control of the perinatal cerebral circulation.” Delivered at a satellite
symposium of the International Society of Cerebral Blood Flow and Metabolism entitled
Perinatal Cerebral Blood Flow and Metabolism, held in Hershey, PA, June, 1997.
16. “Maturation alters the role of calcium in cerebrovascular contractility.” Delivered at a
satellite symposium of the International Society of Cerebral Blood Flow and Metabolism
entitled Mechanisms of Cerebrovascular Function and Regulation, held in Williamsburg,
VA, June, 1997.
17. “Maturational modulation of cerebrovascular signal transduction pathways.” Delivered to
the Department of Pediatric Cardiology of UCLA in Los Angeles, CA, September, 1997.
INVITED LECTURES AND SEMINARS (con’d):
Updated 11/20/10
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Curriculum Vitae: William Julian Pearce
18. “Effects of maturation on serotonergic pharmacomechanical coupling in the ovine cerebral
circulation.” Delivered to the Department of Pharmacology, University of Nevada at Reno,
August, 1999.
19. “Maturational modulation of cerebrovascular pharmacomechanical coupling.” Delivered to
the Department of Physiology, University of Mississippi at Jackson, February, 2001.
20. “Nitric Oxide: Does it really play a role in neonatal ischemic cerebral infarcts?” Delivered to
the Department of Neurosurgery, University of Mississippi at Jackson, February, 2001.
21. “The NO-cGMP Pathway in the developing brain.” Plenary Lecture delivered at “Cerebral
Hypoxia-Ischemia in the Immature Brain: Short and Long-Term Consequences”, an official
satellite symposium of Brain, 2001, held in Taipei, Taiwan, June 9, 2001.
22. “Effects of cerebral maturation on regional nNOS expression, cerebrovascular reactivity to
NO, and responses to ischemia.” Delivered at the conference entitled “Developmental
Cerebral Blood Flow and Metabolism”, held in Hershey, PA, 6/6/02 –6/9/02.
23. “Effects of maturation on serotonergic signal transduction in the ovine cerebral circulation.”
Delivered to the Departments of Physiology and Pediatrics, Case Western Reserve
University in Cleveland, Ohio on March 21, 2003.
24. “Research in Neonatology: Whither goest the future of Physician-Scientists in our era?”
Delivered at a joint NICHHD-American Academy of Pediatrics Symposium held in
Washington, D.C., January, 2004.
25. “Pathophysiological Modulation of Cerebrovascular Regulation in the Immature Brain”
Delivered at a symposia entitled “Childhood Hemiplegia” sponsored by the Novartis
Foundation and held in London, England in April, 2005.
26. “Vascular Consequences of Fetal Cerebral Hypoxia” Delivered at an NICHD-sponsored
workshop entitled “Oxygen in Neonatal Therapies: Controversies and Opportunities for
Research” held at the Bolger Conference Center in Potomac, Maryland in August of 2005.
27. “The Cerebrovascular NO/cGMP/PKG Pathway: Why Does It Change So Dramatically With
Postnatal Age?” Delivered to the School of Medicine, University of South Alabama in
September, 2005.
28. “Pharmacomechanical coupling in the immature cerebral circulation: how changes in
contractility alter reactivity to hypoxia.” Delivered to the Department of Pediatrics, Case
Western Reserve University, Cleveland, Ohio, March, 2006.
29. “Vascular Neuroeffector Maturation” Delivered at the 11th International Vascular
Neuroeffector Mechanisms, and Cardiovascular Pharmacology and Medicine Symposium,
Shanghai-Suzhou, China, June, 2006.
30. “Fetal cerebral oxygenation: The homeostatic role of vascular adaptations to hypoxic stress.”
Delivered at the 37th annual meeting of the International Society for Oxygen Transport to
Tissues held in Cleveland, Ohio, July, 2009.
31. “Does VEGF mediate the mitogenic effects of hypoxia in large arteries?” Delivered at the
36th annual meeting of the Fetal and Neonatal Physiological Society held in Lake
Arrowhead, CA, September, 2009.
32. “Coordinate regulation of vascular smooth muscle gene expression, cell phenotype, and
vessel function.” Delivered at the annual Experimental Biology meetings held in Anaheim,
CA, April, 2010.
Updated 11/20/10
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Curriculum Vitae: William Julian Pearce
PRESENTATIONS AT NATIONAL/INTERNATIONAL MEETINGS:
1. “Normotensive hemorrhage and cerebral blood flow.” Oral presentation at the bi-annual
meeting of the International Society of Cerebral Blood Flow and Metabolism, Copenhagen,
Denmark, June, 1977.
2. “Sympathetic stimulation, cerebral blood flow, and the role of extra-cerebral
venoconstriction.” Oral presentation at the 28th International Congress of Physiological
Sciences, Budapest, Hungary, July, 1980.
3. “The effects of EEG desynchronization on blood flow and oxygen consumption in the rabbit
brain.” Poster presentation at the bi-annual meeting of the International Society of
Cerebral Blood Flow and Metabolism, St Louis, Missouri, June, 1981.
4. “The possible influence of extracerebral vasoconstriction on cerebral hemodynamics.” Poster
presentation at the bi-annual meeting of the International Society of Cerebral Blood Flow
and Metabolism, St Louis, Missouri, June, 1981.
5. “The cerebrovascular selectivity of diltiazem.” Oral presentation at the annual meeting of the
American Association of Neurological Surgeons, held in Washington, D.C., April, 1983.
6. “The cerebrovascular selectivity of diltiazem.” Poster presentation at the bi-annual meeting of
the International Society of Cerebral Blood Flow and Metabolism, Paris, France, July,
1983.
7. “Selective hypoxic inhibition of 5-HT and potassium-induced tone in cerebral arteries.” Oral
presentation at the 68th Meeting of FASEB, St. Louis, Missouri, April, 1984.
8. “Hypoxic relaxation of isolated cerebral arteries.” Poster presentation at the annual meeting of
the Child Neurology Society, Phoenix, Arizona, October, 1984.
9. “The role of membrane hyperpolarization in the direct effects of hypoxia on isolated cerebral
arteries.” Oral presentation at the annual meeting of the Western Pharmacological Society,
Tahoe City, California, January, 1985.
10. “Hypoxic relaxation of potassium-induced tone in newborn and adult cerebral artery
segments.” Oral presentation at the 69th Meeting of the FASEB, Anaheim, California,
April, 1985.
11. “A comparison of the time courses and efficacies of action of verapamil, diltiazem, and
nimodipine on the canine cerebral circulation.” Poster presentation at the bi-annual
meeting of the International Society of Cerebral Blood Flow and Metabolism, Ronneby,
Sweden, June, 1985.
12. “Mechanisms of hypoxic relaxation in isolated cerebral arteries: The effects of extracellular
calcium concentration.” Oral presentation at the Western Pharmacology Society Meeting,
Banff, Alberta, Canada, February, 1986.
13. “Diltiazem improves cerebral autoregulation following hypoxia.” Oral presentation at the
70th Meeting of FASEB, St. Louis, Missouri, April, 1986.
14. “Mechanisms involved in hypoxic relaxation of isolated cerebral arteries.” Poster
presentation at the 30th International Congress of Physiological Sciences, Vancouver, B.C.,
Canada, July, 1986.
15. “The role of the endothelium and calcium as mediators of hypoxic cerebral vasodilatation.”
Poster presentation at the annual meeting of the Child Neurology Society, Boston,
Massachusetts, October, 1986.
16. “Vascular endothelium contributes to hypoxic vasodilatation of cerebral but not carotid
arteries.” Oral presentation at the 71st Meeting of FASEB, Washington, D.C., March,
1987.
Updated 11/20/10
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Curriculum Vitae: William Julian Pearce
PRESENTATIONS AT NATIONAL/INTERNATIONAL MEETINGS (con’d):
17. “The vascular endothelium contributes to hypoxic vasodilatation of rabbit basilar but not
carotid arteries.” Poster presentation at the bi-annual meeting of the International Society
of Cerebral Blood Flow and Metabolism, Montreal, Canada, June, 1987.
18. “Hypoxia increases cyclic GMP in rabbit cranial arteries.” Oral presentation at the 72nd
Meeting of FASEB held in Las Vegas, Nevada, May, 1988.
19. "Hypoxia promotes the release of both relaxing and contracting factors from cranial artery
endothelium." Oral presentation at the annual meeting of the Western Pharmacological
Society held in Breckenridge, Colorado, January, 1989.
20. "Hypoxia promotes the release of both relaxing and contracting factors from the endothelium
of isolated cerebral arteries." Oral presentation at the annual meeting of the Neurosurgical
Section of the American College of Surgeons, Southern California Chapter held in Palm
Springs, California, January, 1989.
21. "Hypoxia inhibits calcium uptake in isolated cerebral arteries." Oral presentation at the 73rd
meeting of FASEB held in New Orleans, Louisanna, March, 1989.
22. "Hypoxia interferes with calcium availability in isolated cerebral arteries." Poster
presentation at the 5th International Symposium on Mechanisms of Vasodilatation held in
Strasbourg, France, July 6-8, 1989.
23. "Gossypol attenuates hypoxic cerebral vasodilatation in the rabbit." Oral presentation at the
74th meeting of FASEB held in Washington, D.C., April, 1990.
24. "Physiological modulation of cerebrovascular endothelial function." Oral presentation at the
annual meeting of the Western Pharmacological Society held in Acapulco, Mexico,
January, 1991.
25. "Fetal cerebral vascular adaptations to long term hypoxia." Poster presentation at the 38th
annual meeting of the Society for Gynecological Investigation held in San Antonio, Texas,
March, 1991.
26. "Developmental changes in endothelial structure and function in human and ovine cerebral
arteries." Poster presentation at the 38th annual meeting of the Society for Gynecological
Investigation held in San Antonio, Texas, March, 1991.
27. "Hypoxia opens ATP-operated K+ channels in rabbit common carotid but not middle
cerebral arteries. Oral presentation at the 74th annual meeting of FASEB held in Atlanta,
Georgia, March, 1991.
28. "Hypoxia opens ATP-operated K+ channels in large but not small rabbit cerebral arteries.
Oral presentation at the 30th biannual meeting of International Society of Cerebral Blood
Flow and Metabolism held in Miami, Florida, June, 1991.
29. "Guanylate cyclase-dependent mechanisms of relaxation are fully functional at birth in
human and ovine cerebral arteries. Poster presentation at the 30th biannual meeting of
International Society of Cerebral Blood Flow and Metabolism held in Miami, Florida, June,
1991.
30. “Chronic hypoxia enhances endothelial and adrenergic neuroeffector function in fetal and
adult ovine cerebral arteries.” Oral presentation at the 75th annual meeting of FASEB held
in Anaheim, California, April, 1992.
31. “Maturational changes in cerebral endothelial function: effects of indomethacin.” Poster
presentation at the 2nd International Symposium on Endothelial-Derived Vasoactive
Factors held in Basel, Switzerland, April, 1992.
Updated 11/20/10
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Curriculum Vitae: William Julian Pearce
PRESENTATIONS AT NATIONAL/INTERNATIONAL MEETINGS (con’d):
32. “Mechanisms of hypoxic and hypercapnic cerebral vasodilatation.” Seminar presented at
the Totman Conference on the Human Cerebral Circulation held in Burlington, Vermont,
October, 1992.
33. “Maturation modulates cerebrovascular cGMP responses to both nitric oxide and hypoxia.”
Oral presentation at the 76th annual meeting of FASEB held in New Orleans, Lousiana,
March, 1993.
34. “Reasons why peak cGMP need not correlate with the magnitude of vasodilatation following
guanylate cyclase activation.” Poster presentation at the annual meeting of the Western
Pharmacological Society held in Kona, Hawaii, February, 1994.
35. “Simultaneous measurements of force and IP3 accumulation in newborn and adult cerebral
arteries.” Oral presentation at the 77th annual meeting of FASEB held in Anaheim,
California, April, 1994.
36. “Determination of the [cGMP] yielding half-maximal activation of G-kinase in intact ovine
basilar arteries.” Oral presentation at the the annual meeting of the Western
Pharmacological Society held in Maui, Hawaii, February, 1995.
37. “The influence of age and acute hypoxia on calcium handling in ovine cerebral and carotid
arteries” Poster presentation at the Experimental Biology meetings held in Atlanta, Georgia,
April, 1995.
38. “Glibenclamide-sensitive potassium channels and age-dependent hypoxic relaxation of small
cerebral arteries.” Oral presentation at the Experimental Biology meetings held in Atlanta,
Georgia, April, 1995.
39. “Physiologic modulation of serotonergic signal transduction mechanisms in ovine cerebral
arteries.” Poster presentation at the Experimental Biology meetings held in Atlanta,
Georgia, April, 1995.
40. “L-NAME reduces infarct volume in a filament model of transient middle cerebral arterry
occlusion in the rat pup.” Poster presentation at the bi-annual meeting of the Society of
Cerebral Blood Flow and Metabolsim held in Köln, Germany, July, 1995.
41. “Maturation modulates the effects of hypoxia on calcium uptake in ovine cerebral arteries.”
Poster presentation at the bi-annual meeting of the Society of Cerebral Blood Flow and
Metabolsim held in Köln, Germany, July, 1995.
42. “Maturation modulates the role of ATP-sensitive potassium channels in hypoxic relaxation
of small cerebral arteries.” Poster presentation at the bi-annual meeting of the Society of
Cerebral Blood Flow and Metabolism held in Köln, Germany, July, 1995.
43. “Maturation modulates multiple mechanisms of serotonergic signal transduction in ovine
cerebral arteries.” Poster presentation at thebi-annual meeting of the Society of Cerebral
Blood Flow and Metabolism held in Köln, Germany, July, 1995.
44. “Maturation increases cerebral NOS activity in SHR by decreasing the Km for L-Arginne.”
Oral presentation at the Experimental Biology meetings held in Washington, D.C., April,
1996.
45. “Rabbit cerebral artery Ca-force curves are left-shifted by 5HT and decreasing age or artery
diameter.” Poster presentation at the Experimental Biology meetings held in Washington,
D.C., April, 1996.
46. “Maturation alters NOS kinetics in the spontaneously hypertensive rat brain.” Oral
presentation at the 23rd annual meeting of the Fetal and Neonatal Physiological Society in
Arica, Chile, August, 1996.
Updated 11/20/10
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Curriculum Vitae: William Julian Pearce
PRESENTATIONS AT NATIONAL/INTERNATIONAL MEETINGS (con’d):
47. “Cofactor additions differentially enhance Vmax and depress Km values for cerebral nitric
oxide synthase in pup and adult SHR.” Oral presentation at the 26th annual meeting of the
Society for Neuroscience hald in Washinton, D.C., November, 1996.
48. “Effects of potassium channel blockers on resting and 5HT induced tone in small cerebral
arteries from control and hypoxic fetal sheep.” Oral presentation at the annual meeting of
the Society for Experimental Biology held in New Orleans, LA, April, 1997.
49. “5HT induced IP3 synthesis and the concept of receptor gain.” Poster presentation at the
annual meeting of the Society for Experimental Biology held in New Orleans, LA, April,
1997.
50. “Physiological variations in cerebrovascular pharmacomechanical coupling.” Poster
presentation at the annual meeting of the Society for Experimental Biology held in New
Orleans, LA, April, 1997.
51. “5HT receptor subtype varies with artery diameter but not with age or chronic hypoxia in
ovine cranial arteries.” Poster presentation at the annual meeting of the Society for
Experimental Biology held in New Orleans, LA, April, 1997
52. “Calcium sensitivity of cerebral arteries: is this an important physiologic regulator of
cerebrovascular reactivity?” Poster presentation at the 18th meeting of the Society for
Cerebral Blood Flow and Metabolism held in Baltimore, MD, June, 1997.
53. “Serotonergic receptor subtype changes with artery diameter but not with age or chronic
hypoxia in ovine cranial arteries.” Poster presentation at the 18th meeting of the Society
for Cerebral Blood Flow and Metabolism held in Baltimore, MD, June, 1997.
54. “Maturational shifts in the role of calcium in cerebrovascular pharmacomechanical coupling”
Poster presentation at a satellite meeting of the 18th meeting of the Society for Cerebral Blood
Flow and Metabolism entitled Mechanisms of Cerebrovascular Function and Regulation held in
Williamsburg, VA, June, 1997.
55. “Maturation increases cerebral NOS activity in SHR by decreasing the Km for L-arginine”
Poster presentation at a satellite meeting of the 18th meeting of the Society for Cerebral
Blood Flow and Metabolism entitled Mechanisms of Cerebrovascular Function and
Regulation held in Williamsburg, VA, June, 1997.
56. “Effects of potassium channel blockers on resting and 5HT induced tone in small cerebral
arteries from control and fetal sheep” Poster presentation at a satellite meeting of the 18th
meeting of the Society for Cerebral Blood Flow and Metabolism entitled Mechanisms of
Cerebrovascular Function and Regulation held in Williamsburg, VA, June, 1997.
57. “Maturational differences in soluble guanylate cyclase activity in ovine cerebral and carotid
arteries” Poster presentation at a satellite meeting of the 18th meeting of the Society for
Cerebral Blood Flow and Metabolism entitled Mechanisms of Cerebrovascular Function
and Regulation held in Williamsburg, VA, June, 1997.
58. “5HT receptor subtype varies with artery diameter but not with age or chronic hypoxia in
ovine cranial arteries” Poster presentation at a satellite meeting of the 18th meeting of the
Society for Cerebral Blood Flow and Metabolism entitled Mechanisms of Cerebrovascular
Function and Regulation held in Williamsburg, VA, June, 1997.
59. “Inositol 1,4,5 trisphosphate receptors in cerebral arteries: changes with development and
high altitude hypoxia.” Poster presentation at a satellite meeting of the 18th meeting of the
Society for Cerebral Blood Flow and Metabolism entitled Mechanisms of Cerebrovascular
Function and Regulation held in Williamsburg, VA, June, 1997.
60. “Signaling pathways governing Ca2+ sensitivity in ovine cerebral arteries of different size
and age.” Oral presentaiton at the annual meeting of the Society for Experimental Biology
held in San Francisco, CA, April, 1998.
Updated 11/20/10
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Curriculum Vitae: William Julian Pearce
PRESENTATIONS AT NATIONAL/INTERNATIONAL MEETINGS (con’d):
61. “Association between vulnerability to ischemic infarct and regional NOS activity in SHR.”
Oral presentaiton at the annual meeting of the Society for Experimental Biology held in
San Francisco, CA, April, 1998.
62. “Maturation alters the role of calcium in 5HT-induced contractions of ovine cerebral
arteries.” Poster presentaiton at the annual meeting of the Society for Experimental Biology
held in San Francisco, CA, April, 1998.
63. “Maturation alters multiple components of pharmacomechanical coupling in ovine carotid
and cerebral arteries.” Oral presentation at the Fetal and Neonatal Physiological Society in
Lake Arrowhead, CA, September, 1998.
64. “Vulnerability to ischemic infarct is associated with regional NOS activity in SHR” Oral
presentation at the annual Society for Neuroscience meetings in Los Angeles, CA,
November, 1998.
65. “Maturation is associated with increased intracellular sensitivity to IP3 in Ovine Cerebral
Arteries.” Oral presentation at the annual national meeting of the American Heart
Association in Dallas, Texas, November, 1998.
66. “Physiological regulation of IP3-induced Ca2+ release in cerebral arteries.” Oral
presentation at the biannual meeting of the International Society for Cerebral Blood Flow
and Metabolism in Copenhagen, Denmark, June 1999.
67. “Core and penumbral nitric oxide synthase activity during cerebral ischemia and reperfusion
in the rat pup.” Oral presentation at the Society for Perinatal Cerebral Hypoxia/Ischemia in
Holte, Denmark, June, 1999.
68. “Acute hypoxia selectively attenuates 5HT receptor density and agonist affinity in fetal and
adult ovine carotids.” Poster presentation at the Second International Conference on
Perinatal Cerebral Blood Flow and Metabolism, held in Hershey, Pennsylvania, June, 2000.
69. “Mechanisms of cGMP-induced cerebral vasodilatation: contractile agonist and
developmental age both make a difference.” Oral presentation at “Brain activation and CBF
control”, held in Tokyo, Japan, on June 6, 2001.
70. “Postnatal maturation enhances IP3-induced Ca2+ release via increased IP3-receptor density
and agonist affinity in ovine cerebral arteries.” Poster presentation at the annual meeting of
the Society for Experimental Biology held in New Orleans, LA, April, 2002.
71. “Maturation alters thin-filament reactivity in ovine basilar arteries.” Poster presentation at the
biannual meeting of the International Society for Cerebral Blood Flow and Metabolism
held in Calgary, Alberta, July, 2003.
72. “Interactive effects of maturation, chronic hypoxia, and artery type on vasorelaxation in
ovine carotid and cerebral arteries.” Poster presentation at the biannual meeting of the
International Society for Cerebral Blood Flow and Metabolism held in Calgary, Alberta,
July, 2003.
73. “Age-dependent effects of ischemia on regional nNOS abundance, activity, and tyrosine
notrosylation.” Poster presentation at the biannual meeting of the International Society for
Cerebral Blood Flow and Metabolism held in Calgary, Alberta, July, 2003.
74. “Maturation depresses stretch-induced myosin light-chain phosphorylation” Poster
presentation at the annual meeting of the Society for Experimental Biology held in
Washington, D.C., April, 2004.
75. “Hypoxia enhances fluid shear-induced activation of eNOS in perfused ovine carotids”
Poster presentation at the annual meeting of the Society for Experimental Biology held in
Washington, D.C., April, 2004.
76. “Physiological modulation of cGMP metabolism by chronic hypoxia in adult and fetal
ovine meddle cerebral arteries.” Poster presentation at the annual meeting of the Society for
Experimental Biology held in Washington, D.C., April, 2004.
77. “Chronic hypoxia modulates endothelium-dependent vasorelaxation through multiple
independent mechanisms in ovine crainial arteries.” Oral presentation at the annual
meeting of the International Society for Oxygen Transport to Tissues held in Bari, Italy,
August, 2004.
Updated 11/20/10
page 22
Curriculum Vitae: William Julian Pearce
PRESENTATIONS AT NATIONAL/INTERNATIONAL MEETINGS (con’d):
78. “Focal Ischemia Decreases Soluble nNOS Abundance In Neonatal But Not Adult SHR
Brain.” Oral presentation at the annual meeting of the Society for Neuroscience held in
San Diego, California in November of 2004.
79. “Maturation enhances ADP, A23187 and fluid shear-induced release of endothelium
derived nitric oxide (NO) from perfused ovine middle cerebral artery segments.” Poster
presentation at the annual meeting of the Society for Experimental Biology held in San
Diego, California in April of 2005.
80. “Stretch-Induced Increases in Cytosolic Calcium and Myosin Phosphorylation Vary with
Postnatal Age in Ovine Cerebral Arteries.” Poster presentation at the annual meeting of the
Society for Experimental Biology held in San Diego, California in April of 2005.
81. “Myogenic stretch of ovine cerebral arteries induces both MLC phosphorylation and thinfilament activation in an age-dependent manner.” Poster presentation at the biannual
meeting of the International Society for Cerebral Blood Flow and Metabolism held in
Amsterdam, Netherlands, June, 2005.
82. “Age-dependent modulation of soluble guanylate cyclase activity by chronic hypoxia in
ovine cranial arteries.” Oral presentation at the annual meeting of the Society for
Neuroscience held in Washington, D.C., November, 2005.
83. “Age-dependent stretch-induced myofilament calcium sensitization in ovine cerebral
arteries”. Poster presentation at the annual meeting of the Society for Experimental
Biology held in San Francisco, California in April of 2006.
84. “Physiological modulation of protein kinase G by chronic hypoxia and maturation in adult
and fetal ovine common carotid arteries.” Poster presentation at the annual meeting of the
Society for Experimental Biology held in San Francisco, California in April of 2006.
85. “Postnatal maturation increases the abundance, but decreases the specific activity of
MLCK in ovine carotids.” Poster presentation at the annual meeting of the Society for
Experimental Biology held in Washington, D.C. in April of 2007
86. “Maturational differences in the contributions of thick- and thin-filament reactivity to
myofilament Ca2+ sensitivity in ovine cerebral arteries.” Poster presentation at the annual
meeting of the Society for Experimental Biology held in Washington, D.C. in April of 2007
87. “Chronic hypoxia and postnatal maturation alter isoform expression and specific activity of
protein kinase G in ovine carotid arteries.” Poster presentation at the annual meeting of the
Society for Experimental Biology held in Washington, D.C. in April of 2007
88. “Postnatal maturation enhances calcium influx, and reduces myofilament Ca++
sensitization in myogenic responses to cerebral artery stretch.” Poster presentation at the
biannual meeting of the International Society for Cerebral Blood Flow and Metabolism
held in Osaka, Japan, May, 2007.
89. “Competing effects among protein kinase G, chronic hypoxia, and postnatal maturation on
5HT agonist affinity in ovine carotid and cerebral arteries.” Poster presentation at the
annual meeting of the Society for Experimental Biology held in San Diego, California in
April of 2008.
90. “VEGF Rescues Loss of Myogenic Tone Induced by Hypoxia-Ischemia In Neonatal Rat
Middle Cerebral Arteries.” Oral presentation at the biannual meeting of the International
Society for Cerebral Blood Flow and Metabolism held in Chicago, Illinois in June of 2009.
91. “Functional Consequences of Injury-Induced Phenotypic Transformation in Cerebral
Arteries.” Oral presentation at the biannual meeting of the International Society for
Cerebral Blood Flow and Metabolism held in Chicago, Illinois in June of 2009.
Updated 11/20/10
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