KALAVRIZIOTI DIMITRA
SHORT CURRICULUM VITAE
WORK ADDRESS: 1 Asclepiou str., University of Patras, School of Medicine, Department of Internal
Medicine, Division of Haematology, Rio-Patras, 26500 Greece PHONE: +302610699129
E-mail: dkalavrizioti@yahoo.com
STUDIES:
2007, Ph.D. in Biochemistry and Molecular Biology, University of Patras, School of Medicine. (Excellent)
Ph.D. thesis: Cloning and characterization of genes encoding subunits of the ribonucleoprotein
complex of Ribonuclease P from the slime mold Dictyostelium discoideum – a key enzyme in the
biogenesis of tRNA.
Supported by Research Fellowship “Hrakleitos” 2002, Ministry of National Education, EPEAEK II.
2002, M.Sc. in Applications of Basic Medical Sciences – Pathobiochemistry, University of Patras, School of
Medicine. (Excellent, 9.4/10)
M.Sc. thesis: Studies on the effects of peptidyltransferase inhibitors on the enzymatic activity of the
Ribonuclease P from the slime mold Dictyostelium discoideum.
2000, B.Sc. in Chemistry, University of Patras, School of Exact Sciences. (Very Good, 7.3/10)
Diploma thesis: Chemical synthesis of imidazolic derivatives - precursors inhibitors of Angiotensin II.
PROFESSIONAL EXPERIENCE:
03/2007-07/2010
Name and address of employer: ELDRUG S.A. – Research and Development Company, Patras Science
Park, Stadium 26504, Platani, Patras.
Position held: Senior Research Scientist (Design and Execution of bio-pharmacological assays, in vitro and
in animal models)
Current Position:
Post. Doctoral Researcher at Division of Haematology, Department of Internal Medicine, School of
Medicine
SCHOLARSHIPS AND HONORS:
 Scholarships from EPEAEK for Postgraduate Studies in Basic Medical Sciences, School of Medicine,
University of Patras for the years 2000-2001 and 2001-2002.
 Award for the best oral presentation entitled: “Composition of the Ribonucleoprotein Complex of
Ribonuclease P from Dictyostelium discoideum: Initial Studies”. 57th Meeting of Hellenic Society of
Biochemistry and Molecular Biology. Athens, December 9-11, 2005.
PARTICIPATION IN RESEARCE PROJECTS:
- Partial purification of RNase P from various eukaryotic and prokaryotic sources. Supported by Research
Fellowship “Pythagoras”2003, Ministry of National Education, EPEAEK II.
- Effect of antibiotics on RNase P activity. Supported by Research Fellowship “K. Karatheodoris” 2003,
Research Committee, University of Patras.
- Cloning and characterization of genes encoding subunits of the ribonucleoprotein complex of
Ribonuclease P from the slime mold Dictyostelium discoideum – a key enzyme in the biogenesis of tRNA.
Supported by Research Fellowship “Hrakleitos” 2002, Ministry of National Education, EPEAEK II.
(All aforementioned projects: Laboratory of Biological Chemistry, School of Medicine, University of
Patras. Head of Group: Prof. D. Drainas)
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INTERNATIONAL SCIENTIFIC PUBLICATIONS:
1. Mouzaki, M.Koutsokera, Z. Dervilli, M. Rodi, D. Kalavrizioti, N. Dimisianos, J. Matsoukas, P.
Papathanasopoulos. Cellular parameters of a remitting-relapsing multiple sclerosis (RR-MS)
patientrefractory to conventional treatments and bone marrow transplantation (BMT) whoresponded
to natalizumab; comparison with other RR-MS patients and healthy controls. Int J Gen Med 2010,
3:313-320.
2. Agelis G, Resvani A, Matsoukas M-T, Tselios T, Kelaidonis K, Kalavrizioti D, Vlahakos D, Matsoukas
J. Towards non-peptide ANG II AT1 receptor antagonists based on urocanic acid: Rational design,
synthesis and biological evaluation. Amino Acids 2010,
3. Toumpeki C, Vourekas A, Kalavrizioti D, Stamatopoulou V, Drainas D. Activation of bacterial
Ribonuclease P by macrolides. Biochemistry 2008, 47: 4112-4118.
4. Kalavrizioti D, Vourekas A, Drainas D. DRpp20 and DRpp40: two protein subunits involved in
Dictyostelium discoideum ribonuclease P holoenzyme assembly. Gene 2007, 400: 52-59.
5. Vourekas A, Kalavrizioti D, Zarkadis IK, Spyroulias GA, Stathopoulos C, Drainas D. A 40.7 kDa
Rpp30/Rpp1 homologue is a protein subunit of Dictyostelium discoideum RNase P holoenzyme.
Biochimie 2007, 89: 301-310.
6. Vourekas A, Kalavrizioti D, Stathopoulos C, Drainas D. Modulation of catalytic RNA biological
activity by small molecule effectors. Mini Rev Med Chem. 2006, 6: 971-978.
7. Kalavrizioti D, Vourekas A, Stamatopoulou V, Toumpeki C, Giannouli S, Stathopoulos C, Drainas D.
RNA-mediated therapeutics: from gene inactivation to clinical application. Curr Top Med Chem. 2006,
6: 1737-1758.
8. Pavlidou D, Vourekas A, Monastirli A, Kalavrizioti D, Tsambaos D, Drainas D. Isolation of
ribonuclease P activity from human epidermis and its regulation by retinoids in vitro. Acta Derm
Venereol. 2006, 86: 114-118.
9. Kalavrizioti D, Vourekas A, Tekos A, Tsagla A, Stathopoulos C, Drainas D. Kinetics of inhibition of
ribonuclease P activity by peptidyltransferase inhibitors. Effect of antibiotics on RNase P. Mol Biol Rep.
2003, 30: 9-14.
PUBLISHED ABSTRACTS:
1. K. Kelaidonis, D. Kalavrizioti, J. Matsoukas, G. Agelis. Synthesis and biological evaluation of 1benzyl and 1-biphenylmethyl substituted imidazole AT1 angiotensin II receptor antagonists J. Peptide
Science, 2010 (Submitted).
2. Toumpeki C, Vourekas A, Kalavrizioti D, Stamatopoulou V, Drainas D. Activation of bacterial
Ribonuclease P by macrolides. 33rd FEBS Congress - 11th IUBMB Conference, FEBS Journal 2008, 275:
74.
3. Tsitlaidou M, Vourekas A, Kalavrizioti D, Stamatopoulou V, Afendra A, Drainas C, Drainas D.
Studies on the ribonuclease P from the ethanologenic bacterium Zymomonas mobilis. 33rd FEBS
Congress - 11th IUBMB Conference, FEBS Journal 2008, 275: 156.
4. Vourekas A, Kalavrizioti D, Theodorakopoulou O, Stamatopoulou V, Toumpeki C, Stathopoulos C,
Drainas D. Composition of the Ribonucleoprotein Complex of Ribonuclease P from Dictyostelium
discoideum. 31st FEBS Congress, FEBS Journal 2006, 273: 359.
PRESENTATIONS AT INTERNATIONAL CONGRESSES:
1. K. Kelaidonis, D. Kalavrizioti, J. Matsoukas, G. Agelis. Synthesis and biological evaluation of 1-benzyl and
1-biphenylmethyl substituted imidazole AT1 angiotensin II receptor antagonists. 31st EPS Symposium
Copenhagen, Denmark, September 05-09, 2010. (Poster)
2. K. Kelaidonis, A. Resvani, M.-E. Androutsou, M.-T. Matsoukas, D. Kalavrizioti, J. Matsoukas and G.
Agelis. Design and Synthesis of non-peptide Angiotensin II AT1 receptor antagonists based on Urocanic acid.
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10th International Conference of Medicinal Chemistry: Drug Discovery and Design, Patras, Greece,
March 18-20, 2009, pp. 106. (Poster)
3. Toumpeki C, Vourekas A, Kalavrizioti D, Stamatopoulou V, Drainas D. Activation of bacterial
Ribonuclease P by macrolides. 33rd FEBS Congress - 11th IUBMB Conference, 28 June – 3 July 2008,
Athens, Greece. (Oral)
4. Tsitlaidou M, Vourekas A, Kalavrizioti D, Stamatopoulou V, Afendra A, Drainas C, Drainas D.
Studies on the ribonuclease P from the ethanologenic bacterium Zymomonas mobilis. 33rd FEBS
Congress - 11th IUBMB Conference, 28 June – 3 July, 2008, Athens, Greece. (Poster)
5. Tsopanoglou EN, Zania P, Gourni D, Kalavrizioti D, Flordellis SC, Maragoudakis EM. Parstatin: a
new cryptic anti-angiogenic peptide. 9th International Conference of Angiogenesis, 22-26 June 2008,
Patras, Greece. (Oral)
6. Vourekas A, Kalavrizioti D, Stamatopoulou V, Toumpeki C, Tzakos A, Stathopoulos C, Drainas D.
Composition of the Ribonucleoprotein Complex of Ribonuclease P from Dictyostelium discoideum. 22th
tRNA Workshop, 1-6 November 2007, Uppsala, Sweden. (Poster)
7. Gourni D, Zania P, Tsilimidou A, Kalavrizioti D, Flordellis CS, Maragoudakis ME, Tsopanoglou EN.
Parstatin, the cleaved peptide of protease-activated receptor-1, as a negative regulator of
angiogenesis. 5th General Meeting of the International Proteolysis Society, 20-24 October 2007, Patras,
Greece. (Poster)
8. Gerolymos KM., Labropoulou E., Koutras A., Kalavrizioti D., Labropoulou C., Leonardos P. Orbital
metastases of gastric cancer: experience of two cases and review of the literature. 3rd International
Congress on Gastrointestinal Oncology, 14-16 June 2007, Crete, Greece. (Poster)
9. Vourekas A*, Kalavrizioti D*, Theodorakopoulou O, Stamatopoulou V, Toumpeki C, Stathopoulos C,
Drainas D. Composition of the Ribonucleoprotein Complex of Ribonuclease P from Dictyostelium
discoideum. 31st FEBS Congress, 24-29 June 2006, Istanbul, Turkey (Poster)
[*the first two authors
have contributed equally to this work]
10. Pavlidou D, Vourekas A, Monastirli A, Kalavrizioti D, Tsambaos D, Drainas D. Isolation of
ribonuclease P activity from human epidermis: Ιnhibition by synthetic retinoids. 10th Dermatology
Symposium, 13-15 November 2004, Prague, Czech Republic. (Poster)
PRESENTATIONS AT NATIONAL CONGRESSES:
1. Keppa P, Kalavrizioti D, Resvani A, Drakou A, Agelis G, Katsoudas S, Matsoukas J and Vlahakos D.
Elsartan (BV6): The new lipid-soluble sartan for transdermal use. 16th Congress of Nephrology. Kos,
June 2-5, 2010, pp. 52. (Poster)
2. Kalavrizioti D, Androutsou MA, Resvani A, Agelis G and Matsoukas J. Elsartan – A selective
antagonist of AT1 receptor of Angiotensin II. 11th Conference of Medicinal Chemistry. Patras, April
25-28, 2010, pp. 54. (Poster)
3. Keppa P, Kalavrizioti D, Resvani A, Agelis G, Drakou A, Matsoukas J and Vlahakos D. Elsartan
(BV6): The new lipid-soluble sartan for transdermal use. 11th Conference of Drug Discovery and
Design. Patras, April 25-28, 2010, pp. 35. (Oral)
4. Resvani A, Kelaidonis K, Kalavrizioti D, Matsoukas J and Agelis G. An efficient synthesis of
substituted imidazole AT1 ANG II receptor antagonists based on 4(5)-butylimidazole. 3rd Hellenic
Symposium on Organic Synthesis. 15-17 October 2009, University of Athens, P45, pp. 1052. (Poster)
5. A. Resvani, K. Kelaidonis, D. Kalavrizioti, J. Matsoukas and G. Agelis. An efficient synthesis of
substituted imidazole AT1 ANG II receptor antagonists based on 4(5)-butylimidazole.3rd Hellenic
Symposium on Organic Synthesis from Chemistry to Biology, Medicine and Materials Science.
Athens, October 15-17, 2009. (Poster)
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Tsitlaidou M, Vourekas A, Kalavrizioti D, Stamatopoulou V, Afendra A, Drainas C, Drainas D.
Studies on Ribonuclease P from the ethanologenic bacterium Zymomonas mobilis. 59th Meeting of
Hellenic Society of Biochemistry and Molecular Biology. Athens, December 7-9, 2007. (Poster)
Toumpeki C, Kalavrizioti D, Vourekas A, Drainas D. Kinetic studies on the activation of ribonuclease
P activity by spiramycin. 58th Meeting of Hellenic Society of Biochemistry and Molecular Biology.
Patras, November 9-11, 2006. (Poster)
Kalavrizioti D, Vourekas A, Drainas D. DRpp20 and DRpp40, two protein subunits of ribonuclease P
from Dictyostelium discoideum. 58th Meeting of Hellenic Society of Biochemistry and Molecular Biology.
Patras, November 9-11, 2006. (Oral)
Tsitlaidou M, Vourekas A, Kalavrizioti D, Stamatopoulou V, Afendra A, Drainas C, Drainas D.
Partial purification of Ribonuclease P activity from the ethanologenic bacterium Zymomonas mobilis.
28th Meeting of Greek Society of Biological Science. Ioannina, May 18-20, 2006. (Oral)
Vourekas A, Kalavrizioti D, Stamatopoulou V, Toumpeki C, Stathopoulos C, Drainas D. Composition
of the Ribonucleoprotein Complex of Ribonuclease P from Dictyostelium discoideum: Initial Studies. 57th
Meeting of Hellenic Society of Biochemistry and Molecular Biology. Athens, December 9-11, 2005.
(Oral)
Vourekas A, Kalavrizioti D, Zarkadis IK, Stathopoulos C, Drainas D. Identification of a gene that
encodes a 40.7 kDa protein associated with Dictyostelium discoideum ribonuclease P holoenzyme. 1st
Meeting of Bioscience. University of Patras, May 19-20, 2005. (Oral)
Vourekas A, Kalavrizioti D, Zarkadis IK, Stathopoulos C, Drainas D. Identification of a gene that
encodes a 40.7 kDa protein associated with Dictyostelium discoideum ribonuclease P holoenzyme. 27th
Meeting of Greek Society of Biological Science. Nafplion, May 12-15, 2005. (Poster)
Bozonelos C, Tekos A, Vourekas A, Kalavrizioti D, Toumpeki C, Drainas D. Differences on the
function and sensitivity of RNase P enzymes from bacterial and eukaryotic inhibitors. 6th Conference
of Medicinal Chemistry. Patras, March 10-12, 2005. (Poster)
Vryzaki E, Vourekas A, Kalavrizioti D, Tsambaos D, Drainas D. Isolation of RNase P activity from
peripheral human lymphocytes. 56th Meeting of Hellenic Society of Biochemistry and Molecular
Biology. Larissa, November 25-27, 2004. (Poster)
Vryzaki E, Vourekas A, Kalavrizioti D, Tsambaos D, Drainas D. Inhibition of Ribonuclease P activity
from human peripheral lymphocytes by retinoids. 5 th Meeting of Clinical Chemistry. Athens,
November 19-21, 2004. (Oral)
Vourekas A, Kalavrizioti D, Zarkadis IK, Tekos A, Stathopoulos C, Drainas D. A 40kDa protein is a
subunit of RNase P holoenzyme from the slime mold Dictyostelium discoideum. 55th Meeting of Hellenic
Society of Biochemistry and Molecular Biology. Athens, November 13-15, 2003. (Poster)
Tekos A, Kalavrizioti D, Alberti A, Vourekas A, Drainas D. Activation of Ribonuclease P by
Macrolides. 55th Meeting of Hellenic Society of Biochemistry and Molecular Biology. Athens,
November 13-15, 2003. (Oral)
Magoulas G, Vourekas A, Pantazaka E, Kalavrizioti D, Stavroulakis D, Tsambaos D, Drainas D,
Papaioannou D. Total Synthesis and RNase P Inhibitory Activity of Novel Acitretin-Type Retinoids.
1st Symposium of Organic Chemistry. Athens 2003. (Poster)
Alberti A, Vittas S, Kalavrizioti D, Vourekas A, Drainas D. Isolation and partial purification of
Ribonuclease P from Dictyostelium discoideum mitochondria. 54th Meeting of Hellenic Society of
Biochemistry and Molecular Biology. Ioannina, October 25-27, 2002. (Poster)
Kalavrizioti D, Vourekas A, Tekos A, Tsagla A, Stathopoulos C, Drainas D. Kinetics of inhibition of
ribonuclease P activity by peptidyltransferase inhibitors. 53rd Meeting of Hellenic Society of
Biochemistry and Molecular Biology. Athens, December 13-15, 2001. (Poster)
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