Standard Operating Procedures
Laboratory Specific
Chemical: Sodium Fluoride
Please fill out the form completely. Print a copy and insert into your
Laboratory Safety Manual and Chemical Hygiene Plan.
Refer to instructions for assistance.
_____________________________________________________________________________
Department:________________________
Date when SOP was written:_______
Date when SOP was approved by the lab supervisor: ___________________
Principal Investigator:___________________________________________________
Internal Laboratory Safety Coordinator/Lab Manager:___________________________________
Laboratory Phone:____________________ Office Phone:_____________________
Emergency Contact:____________________________________________________
(Name and Phone Number)
Location(s) covered by this SOP:__________________________________________
(Building/Room Number)
_____________________________________________________________________________
Type of SOP:
Process
Hazardous Chemical
Hazardous Class
Purpose
(State the procedure the specific chemical is used for in lab/the purpose of the chemical)
Physical & Chemical Properties/Definition of Chemical Group
CAS#:
7681-49-4
Class:
Acutely Toxic
Molecular formula:
NaF
Form (Physical State): White solid, crystals solid, crystalline powder
Melting Point:
Boiling Point:
993°C (1819.4°F)
1704°C (3099.2°F)
Na-F
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Potential Hazards/Toxicity
Toxicity to Animals: Acute oral toxicity (LD50): 52 mg/kg [Rat].
Chronic Effects on Humans:
CARCINOGENIC EFFECTS: A4 (Not classifiable for human or animal.) by ACGIH, 3 (Not
classifiable for human.) by IARC. MUTAGENIC EFFECTS: Mutagenic for mammalian somatic
cells. Mutagenic for bacteria and/or yeast. May cause damage to the following organs: kidneys,
lungs, the nervous system, heart, gastrointestinal tract, cardiovascular system, bones, teeth.
Other Toxic Effects on Humans:
Hazardous in case of skin contact (irritant), of eye contact (corrosive), of ingestion, of inhalation.
Slightly hazardous in case of skin contact (corrosive).
Special Remarks on Chronic Effects on Humans:
May cause adverse reproductive effects (fertililty, fetoxicity), and birth defects based on animal
data. May cause cancer based on animal data. May cause genetic (mutagenic) and tumorigenic
effects.
Personal Protective Equipment (PPE)
Personal Protection:
Splash goggles. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or
equivalent. Gloves.
Personal Protection in Case of a Large Spill:
Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self-contained breathing apparatus
should be used to avoid inhalation of the product. Suggested protective clothing might not be
sufficient; consult a specialist BEFORE handling this product.
Exposure Limits:
TWA: 2.5 (mg/m3) from NIOSH Consult local authorities for acceptable exposure limits.
Engineering Controls
Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne
levels below recommended exposure limits. If user operations generate dust, fume or mist, use
ventilation to keep exposure to airborne contaminants below the exposure limit.
Safety shower and eye wash stations should be easily accessible when sodium fluoride is used.
First Aid Procedures
Eye Contact:
Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty
of water for at least 15 minutes. Cold water may be used. Get medical attention immediately.
Skin Contact:
In case of contact, immediately flush skin with plenty of water for at least 15 minutes while
removing contaminated clothing and shoes. Cover the irritated skin with an emollient. Cold water
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may be used. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical
attention immediately.
Serious Skin Contact:
Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream.
Seek immediate medical attention.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult,
give oxygen. Get medical attention.
Serious Inhalation:
Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie,
belt or waistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform
mouth-to-mouth resuscitation. Seek medical attention.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give
anything by mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or
waistband. Get medical attention immediately.
Serious Ingestion: Not available.
Special Handling and Storage Requirements
Precautions:
Do not ingest. Do not breathe dust. In case of insufficient ventilation, wear suitable respiratory
equipment. If ingested, seek medical advice immediately and show the container or the label.
Avoid contact with skin and eyes. Keep away from incompatibles such as oxidizing agents,
metals, acids, alkalis.
Storage:
Keep container tightly closed. Keep container in a cool, well-ventilated area.
Sodium fluoride and all other acutely toxic materials should be stored in a secondary container in
a designated area away from other chemicals. A refrigerator storing sodium fluoride must be
labeled on the outside with a caution sign noting the presence of sodium fluoride and its hazards.
Spill and Accident Procedure
Carbon monoxide and/or carbon dioxide may be given off in a fire. In the event of fire, evacuate
and bar further entry.
Chemical Spill Dial 911 and x59797
Spill – Help contaminated or injured persons. Evacuate the spill area. Avoid breathing vapors.
Eliminate sources of ignition if the chemical is flammable. If possible, confine the spill to a small
area using a spill kit or absorbent material. Vacuum or sweep up material and place into a
suitable disposal container. Avoid runoff into storm sewers and ditches which lead to waterways.
Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid
generating dusty conditions. Provide ventilation. Prevent spreading of vapors through sewers,
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ventilation systems and confined areas. Evacuate unnecessary personnel. Keep others from
entering contaminated area (e.g., use caution tape, barriers, etc.)
Small (<1 L) – If you have training, you may assist in the clean-up effort. Use appropriate
personal protective equipment and clean-up material for chemical spilled. Double bag spill waste
in clear plastic bags, label and take to the next chemical waste pick-up.
Large (>1 L) – Dial 911 (or 310-825-1491 from cell phone) and EH&S at x59797 for
assistance.
Chemical Spill on Body or Clothes – Remove clothing and rinse body thoroughly in
emergency shower for at least 15 minutes. Seek medical attention. Notify supervisor and EH&S
at x59797 immediately.
Chemical Splash Into Eyes – Immediately rinse eyeball and inner surface of eyelid with
water for 15 minutes by forcibly holding the eye open. Seek medical attention. Notify supervisor
and EH&S at x59797 immediately.
Medical Emergency Dial 911 or x52111
Life Threatening Emergency, After Hours, Weekends And Holidays – Dial 911
(or 310-825-1491 from cell phone) or contact the Ronald Reagan UCLA Medical Center
(emergency room) directly at x52111 (located at 757 Westwood Plaza, enter from Gayley
Avenue). Note: All serious injuries must be reported to EH&S at x59797 within 8 hours.
Non-Life Threatening Emergency – Go to the Occupational Health Facility (OHF),
x56771, CHS room 67-120 (This is on the 6th floor, 7th corridor, room 120. Enter through the
School of Dentistry on Tiverton Drive and proceed to the “O” elevator to the 6th floor.)Hours: M F, 7:30 a.m. to 4:30 p.m. At all other times report to Ronald Regan UCLA Medical Center
(emergency room) at x52111. Note: All serious injuries must be reported to EH&S at x59797
within 8 hours.
Needle stick/puncture exposure (as applicable to chemical handling procedure) – Wash
the affected area with antiseptic soap and warm water for 15 minutes. For mucous membrane
exposure, flush the affected area for 15 minutes using an eyewash station. Page the needle stick
nurse by dialing 231 from a campus phone, enter 93333 when prompted and then enter your
extension. Hours: M – F, 8:00 a.m. to 4:00 p.m. At all other times report to Ronald Regan UCLA
Medical Center (emergency room) at x52111. Note: All needle stick/puncture exposures must be
reported to EH&S at x59797 within 8 hours.
Decontamination/Waste Disposal Procedure
Waste disposal procedures
Once the waste container is full or 90 days have passed, dispose of according the UCLA
EH&S hazardous waste guidelines.
Decontamination of Equipment
Equipment that needs to be decontaminated (for repair or change of location etc.) must be
washed with soapy water and rinsed with copious amounts of water.
Material Safety Data Sheet (MSDS) Location
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(State the location of MSDS)
Hardcopy or electronic copy must be available.
Online MSDS can be accessed at http://msds.ehs.ucla.edu.
Protocol/Procedure
(Add specific description of procedure.)
Note: Any deviation from this SOP requires written approval from PI.
Documentation of Training (signature of all users is required)

Prior to conducting any work with the chemical, designated personnel must provide
training to his/her laboratory personnel specific to the hazards involved in working with
this substance, work area decontamination, and emergency procedures.

The Principal Investigator must provide his/her laboratory personnel with a copy of this
SOP and a copy of the chemical’s MSDS provided by the manufacturer.

The Principal Investigator must ensure that his/her laboratory personnel have attended
appropriate laboratory safety training or refresher training within the year.
I have read and understand the content of this SOP:
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