Program Director/Principal Investigator (Last, First, Middle):
Yang, Catherine F.
BIOGRAPHICAL SKETCH
Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
Catherine F. Yang
eRA COMMONS USER NAME (credential, e.g., agency login)
Professor
YANG5455
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and
residency training if applicable.)
DEGREE
INSTITUTION AND LOCATION
MM/YY
FIELD OF STUDY
(if applicable)
Zhejiang University
Zhejiang University of Technology
Tufts University
Tufts University
Harvard Medical School
B. S
M.S
M.S
Ph.D
Postdoc
01/82
07/85
12/89
05/93
06/93-07/95
Chemistry
Biochemical Engineering
Bioorganic Chemistry
Biochemistry
Biochem/Pharmcology
A. Personal Statement
Dr. Cathy Yang is interested in molecular recognition in biological processes. She has extensive experience in
protein biochemistry, protein-DNA & host-ligand (drug) binding studies, anticancer drug design. She also has a
proven record in designing the novel biosensors for biomedical diagnosis and binding investigation.
B. Positions and Honors
2007.7-present, Chair, Department of Chemistry and Biochemistry, Rowan University, New Jersey
2002.9-present, Professor, Department of Chemistry and Biochemistry, Rowan University, Glassboro, NJ
1999.6-1999.9, Visiting Research Scholar (Sabbatical), Tokyo University of Medicine and Dentistry
1998.9- 2001.9, Associate Professor, Rowan University, Glassboro, NJ
1998.1-1999.7 , Visiting Research Fellow, University of Pennsylvania, Philadelphia, PA
1995.9-1998.8, Assistant Professor, Rowan University, Glassboro, NJ
1996.1-1996.9 , Visiting Scientist, American Health Foundation, White Plains, NY
1993.6-1995.8, Postdoctoral fellow, Harvard Medical School, Boston, MA
1988.1-1988.9 , Research Associate, Boston Biomedical Research Institute, Boston, MA
1983.9-1987.6, Assistant Professor, Zhejiang University of Technology, Hangzhou, China
Award: recipient of “Wall of Fame in Teaching Excellence” (best professor), Rowan, 2004.
recipient of “Wall of Fame in Teaching Excellence” (best professor), Rowan, 2007.
C. Selected Peer-reviewed Publications
Relevant:
1. Li, J.P., Gao, H.L., Chen, Z.Q., Wei, X.P. and Yang, C.F., ‘An Electrochemical Immunosensor for
Carcinoembryonic Antigen Enhanced by Self-assembled Nanogold Coatings on Magnetic particles”,
Analytica Chimica Acta , 2010, 665, 98-104,.
2. Velusamy, V., Arshak, K., Yang, C.F., Yu, L., and Korostynska, O., “Label-free Detection of Bacillus Cereus
DNA Hybridization Using Electrochemical Impedance Spectroscopy for Food Quality Monitoring”, IEEE
SAS Proceedings, February, 2010.
3. Jiao, K. S., Yang, C. F. and Garofalo, J., “Liquid Chromatography Mass Spectrometric Analysis of Organophosphate Treated Chymotripsin”, 2009, American Society of Mass Spectrometry, Philadelphia, June 1-5.
4. Wang, S., Zhang, L., Gazmuri, R. J., Yang, C. F.*, “In-vivo External Sensor for Mitochondrial Injury:
Circulating Cytochrome c”, 2008, IEEE-SAS Proceedings, 13-15.
5. Li, J., Wang, S., Ayoub, I. and Yang, C, “A TiO2-Sol-Gel Derived Prussian Blue Nanoparticles-Based
Glucose Biosensor”, IEEE SAS Proceedings, 2007, 57-62.
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Program Director/Principal Investigator (Last, First, Middle):
Yang, Catherine F.
6. Shen, B., Yang, F. C. and et al, “The Neocarzinostatin Biosynthetic Gene Custer from Streptomyces
carzinostaticus ATCC 15944 Involving Two Iterative Type I Polyketide Synthases”, 2005, Chem. & Biol.,
12, 293-302.
7. Yang, C. F., Jackson, P.J., Xi, Z. and Goldberg, H.I., “Recognition of Bulged DNA by a Neocarzinostatin
Product via an Induced Fit Mechanism”, Bioorganic and Medicinal Chemistry, 2002, 10, 1329-1335.
8. Yang, C. F., Porter, E. Kanyi, D., Boths, J., Hsieh, M-C and Cooperman, B.S., “Design of Synthetic
Hexapeptide Substrates for the Prostate Specific Antigen Using Combinatory Library” Journal of Peptide
Research, 1999, 54 (5), 444-448.
9. Yang, C. F., Goldberg, I. H., Gao, Q.and Smith, R. D., "Binding Specificity of Post-activated
Neocarzinostatin Chromophore Drug-bulged DNA Complex, Studied Using Electrospray Ionization Mass
Spectrometry", J. Mass Spectrometry, 1996, 31, 31-36.
10. Yang, C. F., Stansinopoulos, A., and Goldberg, I.H., "Specific Binding of the Biradical Analog of
Neocarzinostatin to Bulged DNA: Implications for Thiol-independent Cleavage Reaction," Biochemistry,
1995, 34, 2267-2275.
Other Significant:
1. Yang, C. F, “Experiments in Biochemistry and Biotechnology” by Thomson Learning Publishing, 2009.
2. Wang, S., Mahajan, K., Jackson, P., Schmalzel, J. and Yang, C, “A Rapid Electrochemical Probe for DNA
and Electroactive Ligand Interaction”, 2006, IEEE SAS, 45-52.
3. Yang, F. C., Peng, T. Z. and Schmalzel, J., “Design of a Piezoelectric Gene-sensor Using Base-specific
Drug-functionalized Nano-microspheres as Amplifying Probes”, Proceedings of Sicon/04, Sensors for
Industry, 2004, 27, 202-8.
4. Wang, S. F., Peng, T. and Yang, C. F., “Electrochemical determination of interaction parameters for DNA
and mitoxantrone in an irreversible redox process”, Biophysical Chemistry, 2003, 239-248.
5. Wang, S. F., Peng, T. Z. and Yang, C. F., “Investigation of the interaction of DNA and actinomycin D by
cyclic voltammetry”, J. Electroanalytical Chemistry, 2003, 544, 87-92.
6. Zhang, S. G., Peng, T. Z. and Yang, C. F., “A Piezoelectric Gene-Sensor Using Actinomycin DFunctionalized Nano-Microspheres as Amplifying Probes”, J. Electroanalytical Chemistry; 2002, 522, 152157.
7. 19. Peng, T-Z., Q. Cheng and C. F. Yang, “Adsorptive behavior and electrochemical determination of the
anti-fungal agent ketoconazole”, Fresenius J. Anal. Chem., 2001, 370 (8), 1082-1086.
8. Yang, L.J., Peng, T. Z. and Yang, F. C. “Polymeric bilayer modified microelecrodes for in-vivo determination
of neurotransmitter dopamine”, Journal of Chemistry, 2000, 18, 5,708-714.
9. Yang, L. J., Yang, C. F., Qiong, C., Peng, T., “Differential-pulse Adsorptive Stripping Voltammetry of
Ketoconazole_An Oral Antifungal Agent”, Analytical Biochemistry, 2000, 221, 156-162.
10. Yang, C.F, “Proteolytic Processing and Physiological Regulation of Prostate Specific
Antigen”,
Proceedings of National Academy of Sciences Colloquium on Proteolytic Processing, 1999, Beckman
Center of Irvine, California.
11. Goldberg, I. H, Yang, C. F. and et al, Chapter on “Enediynes as Probes of Nucleic Acid Structure" of Book
entitled “DNA and RNA Cleavers and Chemotherapy of Cancer and Viral Diseases” 1996, Kluwer
Academic Publishers.
D. Research Support
1. PI, “Regulatory Role of Prostate Specific Antigen in the Suppression of Advanced Stage of Prostate
Cancer Through Insulin Growth Factors” – Combi Blocks Pharm Inc., 2008-2011.
2. PI, “Development of Vaccine of Peanut Allergy and Poison Ivy”, -Allergy Foundation of South Jersey,
2010-2012.
3. PI, “Proteolytic Activity of Prostate Specific Antigen”-NIH-R15, 2001-2005.
4. CoPI, ““Effect of Lead on Ion Transport in Fathead Gill”, -NIH-R15, 2004-2008.
5. CoPI, “Pollution Prevention & Sustainability”, -NSF-REU, 2001-2005.
6. PI, "Conformational Studies of Bulged Nucleic Acids by a Novel Ligand", Research Corporation- Cottrell
College Award, 1998-2002.
7. CoPI, “Acquisition of a 400 MHz NMR Equipment”, NSF-MRI Award, 2001
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