BIOGRAPHICAL SKETCH
POSITION TITLE
Dr VarvaresouAthanasia,
Associate Professor in Cosmetology,
Pharmacist
Department of Aesthetics and
Cosmetology, Technological
Educational Institution of Athens
Tel: +30 2105385640
Fax: +30 2105385861
Email: avarvares@teiath.gr,
varvaresou@pharm.uoa.gr
Academic Appointments
1985-1989
1990-1991
1991-1996
1996-1996-2007
2007-2012
2012--
Bachelor, School of Pharmacy, University of Athens, Greece
Doctoral Fellow, School of Pharmacy, University of Heidelberg, Germany
Ph.D. studies, School of Pharmacy, University of Athens, Greece
Post-Doctoral Fellow, School of Pharmacy, University of Athens, Greece
(research programs)
Assistant in Research and Education, Department of Aesthetics and
Cosmetology, Technological Educational Institution of Athens
Assistant Professor in Cosmetology, Department of Aesthetics and
Cosmetology, Technological Educational Institution of Athens
Associate Professor in Cosmetology, Department of Aesthetics and
Cosmetology, Technological Educational Institution of Athens
Jobs
1999-2002
2002--
Hospital Pharmacist, Public Hospital Spiliopoulio, Athens, Greece
Consultant in the Development of Drugs and Cosmetics
Research programs
Responsible Investigator: for the research program “THALIS” with title 1.
Incorporation of oligopeptides in cosmetic products-quantative evaluation of functionalskin parameters with biophysical methods. 2. Development and validation of an ion-pair
RP-HPLC method for the determination of oligopeptide in cosmetic product
Investigator: ΕLKE(Κ.Α 70/4/1411, School of Pharmacy, University of Athens),
PENED (Κ.Α 70/3/2742, School of Pharmacy, University of Athens), EPEAEK (K.A
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70/3/3739, School of Pharmacy, University of Athens), THALIS (Department of
Aesthetics and Cosmetology, Technological Educational Institution of Athens) and
ARCHIMEDES III (Department of Aesthetics and Cosmetology, Technological
Educational Institution of Athens)
Teaching Activity
1. Cosmetology I, II, III and Specific Cosmetology [Department of Aesthetics and
Cosmetology, Technological Educational Institution of Athens, (Undergraduate)],
2. Photoaging and oxidative stress: Topical application of cosmetics [Department of
Aesthetics and Cosmetology, Technological Educational Institution of Athens and
Medical School of Athens (Post-graduate],
3. Pharmaceutical chemistry laboratory lessons (School of Pharmacy, University of
Athens (Under-graduate)].
4. Pharmaceutical chemistry laboratory lessons (School of Pharmacy, University of
Athens (Post-graduate)].
5. e-class (Department of Aesthetics and Cosmetology, Technological Educational
Institution of Athens)
6. Open Academic lessons (Department of Aesthetics and Cosmetology,
Technological Educational Institution of Athens)
Αuthor:
1. Varvaresou A. «Specific Cosmetology», KAFKAS Publications, Athens 2011,
ISBN: 978-960-6650-48-9
2. Tsirivas E, Varvaresou A and Papageorgiou S. «Basic Aspects in Cosmetology»,
PARISIANOS Publications, Athens 2013, ISBN: 978-960-394-920-6
3. Tsirivas E and Varvaresou A.«Laboratory lessons in Cosmetology I», ΤΕΙ
Athens
4. Tsirivas E and Varvaresou A. «Laboratory lessons in Cosmetology III», ΤΕΙ
Athens
5. Varvaresou A.«Laboratory lessons in Specific Cosmetology»,ΤΕΙ Athens
Publications in International Journals: 32
Citations (scopus): 294
IF: 26.185
h-index (scopus): 9
Participation in Committees for Master’s Degree:
1. Title: “Indoor air pollution.Legionella”
2. Title: “Cosmetic ingredients with hormone-mimetic activity”
Participation in Committee for PhD Degree:
2
1. Title: “Study and chemical analysis of substances with cosmetic activity”
Department of Pharmacy and Department of Aesthetics and Cosmetology, TEI of
Athens
2. Title: “Study of substances with cosmetic action” Medical School of Athens and
Department of Aesthetics and Cosmetology, TEI of Athens (under evaluation)
Reviewer: Food and Chemical Toxicology (Elsevier), Household and Personal Care
(Tecnoscienze), Current Microbiology (Springer) and Process Biochemistry (Elsevier)
Publications in International Journals
1. Varvaresou A., Tsotinis A., Papadaki-ValirakiA.andSiatra-PapastaikoudiTh.
New Azathioxanthones: Synthesis and Cytotoxicity Biorganic and Medicinal
Chemistry Letters6: 861-864 (1996)
2. Varvaresou A., Tsotinis A., Siatra-Papastaikoudi Th., Papadaki-Valiraki A.,
Thurston D. E., Jenkins T. C. and Kelland L. R. Novel Imidazothioxanthones:
Synthesis, DNA Binding and Cytotoxicity Biorganic and Medicinal Chemistry
Letters 6: 865-870 (1996).
3. Fox K. R., Thurston D. E., Varvaresou A.,Tsotinis A. and Siatra-Papastaikoudi
Th.A Novel Series of DNA Triple Helix-Binding Ligands Biochemistry and
Biophysical Research Communications, 224: 717-720 (1996).
4. Varvaresou A., Tsotinis A., Papadaki-Valiraki A. and Siatra-Papastaikoudi Th.
Synthesis and Structure Elucidation of New Cytotoxic Azathioxanthones
Journal of Heterocyclic Chemistry 33:, 917-921(1996).
5. Varvaresou A., Tsotinis A., Siatra-Papastaikoudi Th. and Calogeropoulou T.
New Pyrazole-Annulated Azathioxanthenes as Potential Intercalators: Synthesis
and Structure Elucidation Journal of Heterocyclic Chemistry 33: 831-835
(1996).
6. Tsotinis A., Varvaresou A., Calogeropoulou T., Siatra-Papastaikoudi Th. and
Tyligada Α. Synthesis and Antimicrobial Evaluation of Indole containing
Derivatives of 1,3,4-Thiadiazole, 1,2,4-Triazole and their open-chain
counterparts Arzneimittel Forschung/Drug Research 47: 307-310 (1997).
7. Varvaresou A., Siatra-Papastaikoudi Th., Tsotinis A., Tsantili-KakoulidouA.
and Vamvakides A. Synthesis, Lipophilicity and Biological Evaluation of Indole
containing Derivatives of 1,3,4-Thiadiazole and 1,2,4-Triazole Il Farmaco53:
320-326 (1998).
8. Varvaresou Α., Siatra–Papastaikoudi Th., Tsantili-Kakoulidou A., Tyligada E.
Synthesis and Biological Properties of some novel Indole Derivatives containing
containing
1,2,4-Triazole and their corresponding thiosemicarbazides
Arzneimittel Forschung/Drug Research 50: 48-54 (2000).
9. Tsantili-KakoulidouΑ., Varvaresou A., Siatra-Papastaikoudi Th.,. Raevsky O.A A
Comprehensive Investigation of the Partitioning and Hydrogen Bonding Behavior of
Indole Containing Derivatives of 1,3,4-Thiadiazole and 1,2,4-Triazole by Means of
Experimental and Calculative Approaches Quantative Strucure Acivity Relationship
18:482-489 (1999).
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10. Varvaresou Α., Iakovou K., Filippatos E., Souli C., Calogeropoulou T.,
Ioannidou I., Kourounakis A.. Pannecouque C., Witvrouw M., Padalko E.,
Neyts J., De Clercq E., Tsotinis A. Synthesis, Antiretroviral and Antioxidant
Evaluation of a Series of new Benzo[b]furan Derivatives Arzneimittel
Forschung/Drug Research 51:156-162 (2001).
11. Iakovou K., Varvaresou A., Kourounakis A. P., Stead K., Sugden D.,
TsotinisA. Design, synthesis and biological evaluation of novel
conformationally restrained melatoninergic analogs Journal of Pharmacy and
Pharmacology 54:147-156 (2002).
12. Varvaresou A. and Iakovou K. Derivatives of 5-Oxy-pyrido[2,3-b]quinoxaline-9carboxylic acid: A new Tricyclic System Useful for the Synthesis of Potential
Intercalators Journal of Heterocyclic Chemistry 39 : 1173-1176 (2002).
13. Varvaresou Α., Tsaoula E. and Tsirivas E. The influence of the addition of melatonin
to a magnesium ascorbyl phosphate- containing formulation on the mechanical
properties of human skin Review of Clinical Pharmacology and
Pharmacokinetics18:177-181 (2004).
14. Varvaresou A., Iakovou K., Gikas E., Fichtner I., Fiebig H.H., Kelland L.R.,
Double J.A., BibbyM.C. and Hendriks H.R. Antitumor Activity of
Imidazothioxanthones in Murine and Human Tumor Models In Vitro and In
Vivo Anticancer Research 24: 907-920 (2004).
15. Iakovou K.,Varvaresou A., Bruni G., Massarelli P., Vavayannis A. and Kazanis M.
Anti-inflammatory and Analgesic Activity οf two dicyclic analogues of
Acetaminophen and its regioisomer 3-Hydroxyacetanilide Pharmaceutical Chemistry
Journal 38: 239-242 (2004).
16. Varvaresou A., Tsirivas E., Tsaoula E., Protopapa E.Oxidative Stress,
Photoaging and Topical antioxidant Protection Review of Cilnical
Pharmacology and Pharmacokinetics18: 261-266(2004)
17. Varvaresou A., Tsirivas E., Tsaoula E., Protopapa E.Synthetic colorants commonly
used in lipsticks Review of Clinical Pharmacology and Pharmacokinetics18: 11-16
(2005).
18. Varvaresou A., Tsirivas E., Tsaoula E. Isothiazolinone Biocides as
Preservatives in Cosmetics Review of Cilnical Pharmacology and
Pharmacokinetics 19:105-108 (2005).
19. Varvaresou A., Tsirivas E., Tsaoula E., Protopapa E. The influence of
magnesium ascorbyl phosphate on moisturization of stratum corneum Review of
Cilnical Pharmacology and Pharmacokinetics19: 139-142 (2005).(
20. Varvaresou A. Percutaneous absorption of organic sunscreens Journal of
Cosmetic Dermatology 5: 53-57 (2006).
21. Varvaresou A., Tsirivas E., Iakovou K., Gikas E., Papathomas Z., Vonaparti
A., Panderi I. Development and validation of a reversed-phase ion-pair liquid
chromatography method for the determination of magnesium ascorbyl
phosphate and melatonin in cosmetic creams Analytica Chimica Acta 573-574:
284-290 (2006).
22. Papageorgiou S., Varvaresou A., Hatziantoniou S., Tsirivas E., Demetzos C.,
Papaioannou G..Photostability of retinoids: The influence of the container
Review of Cilnical Pharmacology and Pharmacokinetics 21: 49-53 (2007).
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23. Papageorgiou S., Varvaresou A. and Tsirivas E. The Development of Selfpreserving Cosmetics Review of Cilnical Pharmacology and Pharmacokinetics22:
455-460 (2008).
24. Varvaresou A., Papageorgiou S., Tsirivas E., Protopapa E., Kintziou H., Kefala V.
and Dementzos C. Self-preserving cosmetics International Journal of Cosmetic
Science 31: 163-175 (2009).
25. Papageorgiou S., Varvaresou A., Tsirivas E. and Demetzos C. New alternatives to
cosmetics preservation Journal of Cosmetic Science61: 107-123 (2010).
26. Varvaresou A. and Iakovou K. Molecular Modeling Study of Intercalation
Complexes of Tricyclic Carboxamides with d(GCGC)2, d(CGCG)2 and
d(CGCGCG)2. Journal of Molecular Modeling, 8: 2041-2050 (2011)
27. Varvaresou A. and Papageorgiou S. The development of self-preserving gels
Household and Personal Care Today, 18-21 (2011)
28. Papagianni P., Varvaresou A., Papageorgiou S., Panderi I. Development and
validation of an ion-pair RP-HPLC method for the determination of
oligopeptide-20 in cosmeceuticals Journal of Pharmaceutical and Biomedical
Analysis 56:645-649 (2011)
29. Kefala V., Kintziou H., Protopapa E., Varvaresou A., Papageorgiou S.,
RaikouV. Tyrosinase inhibitors from natural Sources for Potential use in the
Aesthetic and Cosmetology Practice Review of Clinical Pharamacology and
Pharmacocinetics (International Edition) 25: 65-68 (2011).
30. Varvaresou Α., Papageorgiou S., Protopapa E. and KatsarouA. Efficacy and
tolerance study of an oligopeptide with potential anti-aging activity Cosmetics,
Dermatological Sciences and Applications 1: 133-140 (2011).
31. Kefala V., Kintziou H., Protopapa E., Varvaresou A., Papageorgiou S., Raikou
V. Tyrosinase inhibitors from natural Sources for Potential use in the Aesthetic
and Cosmetology Practice Review of Clinical Pharamacology and
Pharmacocinetics (International
Edition) 25: 65-68 (2011).
32. Varvaresou Α., Papageorgiou S., Protopapa E. and Katsarou A. Efficacy and
tolerance study of an oligopeptide with potential anti-aging activity Cosmetics,
Dermatological Sciences and Applications 1: 133-140 (2011).
33. Kalogria Ε., Varvaresou A., Papageorgiou S., Tsaknis I., Protopapa Ε, Matikas
Α.and Panderi Ι. Development and validation of a pre-column derivatization
HPLC procedure for the quantitation of aluminiumchlorohydrate in
antiperspirant creams using quercetin as chromogenic reagent.
Chromatographia submitted (2014)
Participations in International Conferences:12
1. Varvaresou A., Tsotinis A., Siatra-Papastaikoudi Th., Papadaki-Valiraki
A., Thurston D. E., Jenkins T. C. and Kelland L. R.. Synthesis of new
cytotοxicimidazothioxanthones and DNA binding studies XIVth
International Symposium on Medicinal Chemistry, Maastricht, The
Netherlands, 8-12 September, 1996.
2. Varvaresou A., Siatra-Papastaikoudi Th., Tsantili -Kakoulidou A. Α
critical appraisal of log P calculation procedures using partition
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coefficients and HPLC capacity factors for a series of Indole containing
Derivatives of 1,3,4 -Thiadiazole and 1,2,4-Triazole 12th European
Symposium on Quantitative Structure-Activity Relationships,
Copenhagen, 23-28 August, 1998
3. Tsotinis A., Iakovou K., Varvaresou A., Garratt P. J., Teh M. T. and
Sugden D. Melatonin Receptor Ligands: Synthesis and Biological
Evaluation of New Melatonin Derivatives 6th Conference in Advanced
Medicinal Chemistry, Thessaloniki, 28-30 May 1999
4. Varvaresou Α., Tsaoula E. and Tsirivas E. The influence of melatonin
on the mechanical properties of human skin. A preliminary study
International Conference on Oxidative stress in Skin Biology and
Medicine, Andros, Greece 18-21 September 2003
5. Varvaresou A., Tsirivas E., Papathomas Z., Iakovou K., Gikas E.,
Panderi I. Development and validation of a reversed-phase ion-pair
liquid chromatography method for the determination of magnesium
ascorbyl phosphate and melatonin in cosmetic creams Instrumental
Methods of Analysis-IMA 2005, Crete, Greece, Octomber 2005.
6. Papageorgiou S., Varvaresou A. and Tsirivas E. The antimicrobial
efficacy of natural ingredients for the production of self-preserving
cosmetics7th Joint Meeting of AFERP,ASP,GA,PSE & SIF, Natural
Products with Pharmaceutical, Nutraceutical, Cosmetic and
Agrochemical Interest, August 3-8, 2008, Athens, Greece.
7. Varvaresou A., Papageorgiou S., Tsaoula E. and Tsirivas E. The
toxicological safety of natural preservatives in the «Preservative free»
cosmetic products XIIIthCosmoderm Joint Meeting of ESCAD and the
Hellenic Society of Dermatology and Venereology, December 12-14,
2008, Athens, Greece.
8. Papageorgiou S., Varvaresou A., Tsaoula E., Tsirivas E. and Protopapa
E. The efficacy of Vitamin E and Horse Chestnut, Guarana and Alfalfa
extracts related to the decrease of dark circles and bags under the eyes
7th Anti-Aging Medicine World Congress, AMWC, March 19-21, 2009,
Monaco.
9. Papageorgiou S., Varvaresou A., Tsaoula E. and Protopapa E. Efficacy
Evaluation and Cytotoxic Profile of a Skin-Depigmentating Cosmetic
Product 8th Anti-Aging Medicine World Congress, AMWC, April 8-10,
2010, Monaco.
10. Papagianni P.,Varvaresou A., Papgeorgiou S., Panderi I. Determination
of oligopeptide-20 in cosmeceuticals by an isocratic ion-pair RP-HPLC
method with heptafluorobutyric acid as ion-pair reagenton a cyanopropyl
reversed phase column The 7th International Conference on Instrumental
methods of Analysis Modern Trends and Applications 18-22 September
2011, Chania, Crete.
11. Pnevmatikatos S., Kintziou H., Varvaresou A, Papageorgiou S.,
Protopapa E., Kefala V. Effect of sea mud compresses from Messolonghi
lagoon as a treatment for cellulite [Experimental study] 9th World
congress of Cosmetic Dermatology, 27-30 June 2013 Athens, Greece.
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12. Kalogria Ε., Varvaresou A., Papageorgiou S., Tsaknis I., Protopapa E.,
Panderi I. Development and evaluation of a pre-column metal complex
formation HPLC procedure for the detection and quantitation of
aluminum in an antiperspirant cream 8th International Congress on
Instrumental Methods of Analysis Modern Trends and Applications 1519 September, 2013, Thessaloniki, Greece.
Participations in National Conferences: 17
Other activities
1. Responsible for the Laboratory of Cosmetology, Department of Aesthetics and
Cosmetology, Technological Educational Institution of Athens
2. Responsible for the Division of Aesthetics, Department of Aesthetics and
Cosmetology, Technological Educational Institution of Athens
Research Interests
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Synthesis and pharmacological study of new compounds with antitumor, antiinflammatory, antimicrobial and antioxidant activities (Xanthenes, benzofurans,
thiadiazoles, melatoninergic derivatives, pyridoquinoxalines).
Molecular modeling of DNA intercalative compounds
NMR Spectroscopy
Interaction of cosmetic dyes with DNA (xanthenes)
Preservation of cosmetics-thiadiazoles
Self-preserving cosmetics
Influence of antioxidant compounds on human skin elasticity
Development of anti-aging cosmetics
Influence of oligopeptides on human skin elasticity and wrinkles
Efficacy tests of cosmetics: Skin elasticity, profilometry, sebum, moisturization
etc
Lipophilicity structure-activity relationships
UVA and UVB sunscreens
Skin penetration
Instrumental Experience
ΝΜR Bruker AC 400 MHz, ΝΜR Bruker 200 MHz, IR Perkin -Elmer 883, UV
Perkin- ElmerModelLambda 4B, HPLC WatersAssociatesModel 600E, HPLC
GBCLC 1210 , HPLC Waters 1525 Cutometer SEM 474, Sebumeter SM 810,
Corneometer CM 8, Μexameter, Visioscan, Skin Visiometer, Tewameter, Skin
pHmeter, Determination SPF in vitro, Transdermal delivery (Franz cells)
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