2016 Winter Conference Short Courses
2016 Winter Conference Short Courses
Friday, January 8 - Monday, January 11, 2016
Schedule
Analysis by Plasma Spectrochemistry
SA-01 Elemental Testing in Toxicology Using ICP-MS, Saturday, January 9, 1 pm, Frederick Strathmann and Christian
Law, ARUP Laboratories, 500 Chipeta Way, Salt Lake City, UT 84108, frederick.g.strathmann@aruplab.com
SA-02 ICP-MS and ICP-MS/MS: Critical New Tools for Clinical and Biological Studies, Sunday, January 10, 8 am,
Julio Landero-Figueroa, Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221-0172,
julio_landero80@yahoo.com
SA-03 Speciation Analysis: Complementarity of Elemental, Isotopic and Molecular Mass Spectrometry in
Environmental and Life Sciences. Monday, January 11, 7 pm, Joanna Szpunar, Laboratoire de Chimie Analytique Bioinorganique et Environnement, CNRS UMR 5254-IPREM, Hélioparc, 2, Av. Président Angot, 64053 Pau, France,
joanna.szpunar@univ-pau.fr
SA-04 Arsenic and Mercury Speciation in Biological Samples, Sunday, January 10, 7 pm, Jörg Feldmann and Eva
Krupp, University of Aberdeen, College of Physical Sciences, Department of Chemistry, Trace Element Speciation
Laboratory, Aberdeen AB24 3UE Scotland, United Kingdom, j.feldmann@abdn.ac.uk, e.krupp@abdn.ac.uk
SA-05 Clinical ICP-MS I, Sunday, January 10, 1 pm, Kathleen L. Caldwell, klc7@cdc.gov, and Cynthia Ward,
dmo9@cdc.gov, 4770 Buford Highway, Mailstop F-18, Atlanta, GA 30341-3724
SA-06 Clinical ICP-MS II, Responding to Inorganic Chemical Exposure Evaluations and Emergency Response.
Sunday, January 10, 7 pm, Robert Jones and Kathleen L. Caldwell, 4770 Buford Highway, Mailstop F-50, Atlanta, GA
30341-3724, rljones@cdc.gov, klc7@cdc.gov
SA-07 ICPMS for the Characterization of Nanomaterials: Focusing on the Exposure to Nanoproducts, Saturday,
January 9, 7 pm, Petra Krystek, Institute for Environmental Studies (IVM), VU University Amsterdam, De Boelelaan 1087,
NL-1081 HV Amsterdam, The Netherlands, petra.krystek@ivm.vu.nl
SA-08 USP <232> and <233> and ICH-Q3D: Next Steps and Compliance, Saturday, January 9, 1 pm, Nancy Lewen,
BMS, 1 Squibb Dr., New Brunswick, NJ 08903, nancy.lewen@bms.com
SA-09 Analysis of Petroleum and Petroleum Products, Sunday, January 10, 7 pm, José Luis Todolí, Department of
Analytical Chemistry, Nutrition and Food Sciences, University of Alicante, PO Box 99, 03080 Alicante, Spain,
jose.todoli@ua.es
Spectrochemical Instrumentation
SI-01 Calibration, Optimization, and Interferences in Plasma Spectrochemical Analysis, Sunday, January 10, 8 am,
José A.C. Broekaert, Institute for Inorganic and Applied Chemistry, University of Hamburg, Martin-Luther-King-Platz 6, D20146 Hamburg, Germany, jose.broekaert@chemie.uni-hamburg.de
SI-02 Quantifying Complex Nanoparticles: Direct Coupling of Field Flow Fractionation with Single Particle
Inductively Coupled Plasma Mass Spectrometry, Saturday, January 9, 8 am, James F. Ranville, Colorado School of
Mines, Department of Chemistry and Geochemistry, Golden, CO 80401, jranvill@mines.edu; Chady Stephan,
PerkinElmer; Soheyl Tadjiki, Postnova Analytics
SI-03 High-Resolution ICP-MS, Sunday, January 10, 7 pm, Norbert Jakubowski, BAM, Federal Institute for Materials
Research, Richard-Willstätter-Strasse11, 12498 Berlin, Germany, norbert.jakubowski@bam.de
SI-04 Opportunities, Challenges, and Application of Glow Discharge Techniques, Sunday, January 10, 1 pm, Volker
Hoffmann, Leibniz Institute for Solid State and Materials, Research Dresden, PO Box 27 00 16, D-01171 Dresden,
Germany, v.hoffmann@ifw-dresden.de; Cornel Venzago, AQura GmbH, Postcode 915-d115, Rodenbacher Chaussee 4,
63457 Hanau-Wolfgang, Germany, cornel.venzago@aqura.de
SI-05 Time-of-Flight and Distance-of-Flight Mass Spectrometry for Elemental, Speciation, and Metallomic
Analysis, Sunday, January 10, 8 am, Steven J. Ray and Gary M. Hieftje, Indiana University, Department of Chemistry,
800 E. Kirkwood Ave., Bloomington IN 47405-7102, sjray@indiana.edu, hieftje@indiana.edu
SI-06 ICP-MS I: Introduction, Saturday, January 9, 8 am, R. Sam Houk, Iowa State University, Ames Laboratory USDOE
Department of Chemistry, Ames, IA 50011, rshouk@iastate.edu
SI-07 ICP-MS II: Advanced Topics, Saturday, January 9, 1 pm, John Olesik, Ohio State University, School of Earth
Sciences, 125 S. Oval Mall, 026 Mendenhall Labs, Columbus, OH 43210-1002, olesik.2@osu.edu
SI-08 Theory and Practical Use of Reaction Cells and Collision Cells for ICP-MS, Sunday, January 10, 1 pm, John
Olesik, Ohio State University, School of Earth Sciences 125 S. Oval Mall, 026 Mendenhall Labs, Columbus, OH 432101002, olesik.2@osu.edu
SI-09 Understanding and Overcoming Matrix Effects in ICP-OES and ICP-MS, Monday, January 11, 7 pm, José Luis
2016 Short Course Program and Abstracts
Page 1
2016 Winter Conference Short Courses
Todolí, Department of Analytical Chemistry, Nutrition and Food Sciences, University of Alicante, PO Box 99, 03080
Alicante, Spain, jose.todoli@ua.es
SI-10 Identification and Correction of Interferences in Practical ICP-OES, Saturday, January 9, 7 pm, Deborah
Bradshaw, Atomic Spectroscopy Consulting, PO Box 536307, Orlando, FL 32853-6307, bradshawdk@cs.com
SI-11 Identification and Correction of Interferences in Practical ICP-MS, Sunday, January 10, 7 pm, Deborah
Bradshaw, Atomic Spectroscopy Consulting, PO Box 536307, Orlando, FL 32853-6307, bradshawdk@cs.com
SI-12 Direct Analysis with Ambient Mass Spectrometry: Chemical Analysis of Things as They Are, Saturday,
January 9, 7 pm, Jacob Shelley, Kent State University, Department of Chemistry, 214 Williams Hall, Kent, OH 44242,
jshelley@kent.edu, and Carsten Engelhard, University of Siegen, Department of Chemistry & Biology, Analytical
Chemistry, D-57076 Siegen, Germany, engelhard@chemie.uni-siegen.de
Sample Introduction Approaches
SS-01 A Practical Guide to Nebulizers and the Part They Play in Modern Sample Introduction, Sunday, January 10,
1 pm, Gerhard Meyer, Promerus LLC, 9921 Brecksville Rd., Breckville, OH 44141, gary.meyer@promerus.com, and
Geoff Coleman, Meinhard, 700 Corporate Circle, Golden, CO 80401-5636, gcoleman@meinhard.com
SS-02 Laser Ablation Mass Spectrometry I, Friday, January 8 1 pm, Henry Longerich, Earth Sciences, Memorial
University of Newfoundland, St. John’s, NL A1B 3X5, Canada, henryl@mun.ca, and Detlef Günther, Laboratory of
Inorganic Chemistry, ETH Hönggerberg, HCI, G113, CH-8093, Zürich, Switzerland, guenther@inorg.chem.ethz.ch
SS-03 Laser Ablation Mass Spectrometry II, Friday, January 8, 7 pm, Detlef Günther, Laboratory of Inorganic
Chemistry, ETH Hönggerberg, HCI, G113CH-8093, Zürich, Switzerland, guenther@inorg.chem.ethz.ch, and Henry
Longerich, Earth Sciences, Memorial University of Newfoundland, St. John’s, NL A1B 3X5, Canada, henryl@mun.ca
SS-04 Laser Ablation Fundamentals, Applications, and Directions, Monday, January 11, 7 pm, Jhanis Gonzalez,
Applied Spectra, Inc., 46661 Fremont Blvd, Fremont, CA 94538, jhanis@appliedspectra.com, jjgonzalez@lbl.gov; Rick
Russo, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, Berkeley, CA 94720, rerusso@lbl.gov
SS-05 Laser-Induced Breakdown Spectroscopy (LIBS), Sunday, January 10, 7 pm, Nicoló Omenetto, University of
Florida, Department of Chemistry, Gainesville FL 32611, omenetto@chem.ufl.edu
SS-06 Practical Applications of Laser-Induced Breakdown Spectroscopy (LIBS), Saturday, January 9, 8 am, Sharla
Woods, Bristol-Myers Squibb, 1 Squibb Dr, Mail Stop 107-1-1250, New Brunswick, NJ 08903, Sharla.Woods@bms.com
SS-07 Traditional vs. Specialized Sample Introduction Systems for ICP-AES and MS. Saturday, January 9, 7 pm,
Vassili
Karanassios,
University of
Waterloo,
Department
of
Chemistry,
Waterloo,
ON,
Canada,
vkaranassios@uwaterloo.ca
Plasma Spectrochemical Techniques
ST-01 On-the-Job Skills for Technology Developers (Things You Were Not Taught in School), Saturday, January 9,
8 am, Andrew T. Zander, Consultant, Gerson Lehman Group, 1632 Hickory Ave, Torrance, CA 90503,
atzander@earthlink.net; Megan Cotugno, The Rand Corporation, Santa Monica, CA
ST-02 Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) Using Isotope Dilution (ID): Fundamentals and
Applications to Elemental and Elemental Species Analysis, Sunday, January 10, 8 am, Jörg Bettmer and Maria
Montes-Baryon, Universidad de Oviedo, Departamento de Química Física y Analítica, C/ Julián Clavería 8, E-33013
Oviedo, Spain, bettmerjorg@uniovi.es, montesmaria@uniovi.es
ST-03 Extraction Chromatography for Enhanced Elemental and Isotopic Analysis by ICPMS, Saturday, January 9, 8
am, Michael Ketterer, Department of Chemistry and Biochemistry, Metropolitan State University of Denver, Campus Box
52, PO Box 173362, Denver, CO 80217-3362, mkettere@msudenver.edu
ST-04 Environmental Forensics: ICPMS-Based Isotopic Methods, Saturday, January 9, 7 pm, Michael Ketterer,
Department of Chemistry and Biochemistry, Metropolitan State University of Denver, Campus Box 52, PO Box 173362,
Denver, CO 80217-3362, mkettere@msudenver.edu
ST-05 Tracing Element Metabolism in Animals and Humans Using Stable Isotope Techniques, Monday, January
11, 7 pm, Thomas Walczyk, Department of Chemistry, National University of Singapore, Science Drive 4, Singapore
117543, walczyk@nus.edu.sg
ST-06 Contamination Control for Trace Element Analysis, Sunday, January 10, 1 pm, Brad McKelvey, Seastar
Chemicals Inc., 10005 McDonald Park Rd., Sidney, BC V8L 5Y2, Canada, bmckelvey@seastarchemicals.com
ST-07 Adjusting Your Laboratory for Trace Analyses, Sunday, January 10, 8 am, Ela Bakowska, Elba Elemental
Consulting, PO Box 1050, Corning, NY 14830, ela_bakowska@yahoo.com
ST-08 Clean Microwave Digestions for Ultra-Trace Analysis, Monday, January 11, 7 pm, Joaquim A. Nóbrega,
Federal University of São Carlos, Department of Chemistry, São Carlos, SP, Brazil, djan@terra.com.br
ST-09 Microwave-Assisted Sample Preparation for Spectrochemistry, Sunday, January 10, 8 am, Joaquim A.
Nóbrega, Federal University of São Carlos, Department of Chemistry, São Carlos, SP, Brazil, djan@terra.com.br
ST-10 Plasma Diagnostics: Fundamentals, Measurements, and Applications, Saturday, January 9, 7 pm, Igor B.
2016 Short Course Program and Abstracts
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2016 Winter Conference Short Courses
Gornushkin, BAM, Federal Institute for Materials Research and Testing, Berlin, Germany, igor.gornushkin@bam.de
ST-11 Uncertainty Budget Cookbook – Ready to Serve, Saturday, January 9, 1 pm, Thomas Prohaska, University of
Natural Resources and Life Sciences, Department of Chemistry, VIRIS Laboratory, Konrad, Lorenz Strasse 24, A-3430
Tulin, Austria, thomas.prohaska@boku.ac.at
ST-12 ETV-AAS, ICP-AES/ICP-OES, Quadrupole and Sector Field ICP-MS Method Development Problem Solving,
Saturday, January 9, 1 pm, R. Steven Pappas and Mark R. Fresquez, Centers for Disease Control and Prevention, 4770
Buford Hwy, MS F-44, Atlanta, GA 30341-3717, rpappas@cdc.gov
ST-13 Sample Preparation Problem Solving for Atomic Mass Spectrometry, Sunday, January 10, 1 pm, R. Steven
Pappas and Naudia Gray, Centers for Disease Control and Prevention, 4770 Buford Hwy NE, MS F44, Bldg 110, Atlanta,
GA 30341-3717, rpappas@cdc.gov
ST-14 Validation Assessment, Sunday, January 10, 1 pm, Rob Ritsema, National Institute for Public Health and the
Environment (RIVM), PO Box 1, 3720 BA Bilthoven, The Netherlands, rob.ritsema@rivm.nl; Petra Krystek, Institute for
Environmental Studies (IVM), VU University Amsterdam, De Boelelaan 1087, NL-1081 HV Amsterdam, The Netherlands,
petra.krystek@ivm.vu.nl
ST-15 Atomic Spectroscopy for Forensic Applications, Sunday, January 10, 8 am, Suresh Kumar Aggarwal, 1006,
Sunflower, Neelkanth Gardens, Govandi-East, Mumbai 400088, India, skaggr2002@gmail.com
ST-16 Field-Flow Fractionation in Hyphenated Techniques: Measurement Quality Control and Applications in
Healthcare and Environmental Safety, Monday, January 11, 7 pm, Heidi Goenaga-Infante, LGC Limited, Queens Road,
Teddington, Middlesex TW11 OLY, UK, heidi.goenaga-infante@lgcgroup.com
Technical Seminar
TS-01 Measurement of Size, Shape and Density of Nanoparticles Using Centrifugal Field-Flow Fractionation and a
Multi Detection System, Saturday, January 9, 1 pm, Soheyl Tadjiki, Postnova Analytics, Inc., Salt Lake City, UT84102,
soheyl.tadjiki@postnova.com
Schedule by Date and Time
Friday, January 8, 1 pm
SS-02 Laser Ablation Mass Spectrometry I, Henry Longerich, Earth Sciences, Memorial University of Newfoundland,
St. John’s, NL A1B 3X5, Canada, henryl@mun.ca, and Detlef Günther, Laboratory of Inorganic Chemistry, ETH
Hönggerberg, HCI, G113, CH-8093, Zürich, Switzerland, guenther@inorg.chem.ethz.ch
Friday, January 8, 7 pm
SS-03 Laser Ablation Mass Spectrometry II, Detlef Günther, Laboratory of Inorganic Chemistry, ETH Hönggerberg,
HCI, G113CH-8093, Zürich, Switzerland, guenther@inorg.chem.ethz.ch, and Henry Longerich, Earth Sciences, Memorial
University of Newfoundland, St. John’s, NL A1B 3X5, Canada, henryl@mun.ca
Saturday, January 9, 8 am
SI-02 Quantifying Complex Nanoparticles: Direct Coupling of Field Flow Fractionation with Single Particle
Inductively Coupled Plasma Mass Spectrometry, James F. Ranville, Colorado School of Mines, Department of
Chemistry and Geochemistry, Golden, CO 80401, jranvill@mines.edu; Chady Stephan, PerkinElmer; Soheyl Tadjiki,
Postnova Analytics
SI-06 ICP-MS I: Introduction, Saturday, R. Sam Houk, Iowa State University, Ames Laboratory USDOE Department of
Chemistry, Ames, IA 50011, rshouk@iastate.edu
SS-06 Practical Applications of Laser-Induced Breakdown Spectroscopy (LIBS), Sharla Woods, Bristol-Myers
Squibb, 1 Squibb Drive, Mail Stop 107-1-1250, New Brunswick, NJ 08903, Sharla.Woods@bms.com
ST-01 On-the-Job Skills for Technology Developers (Things You Were Not Taught in School), Andrew T. Zander,
Consultant, Gerson Lehman Group, 1632 Hickory Ave, Torrance, CA 90503, atzander@earthlink.net; Megan Cotugno,
The Rand Corporation, Santa Monica, CA
ST-03 Extraction Chromatography for Enhanced Elemental and Isotopic Analysis by ICPMS, 8 am, Michael
Ketterer, Department of Chemistry and Biochemistry, Metropolitan State University of Denver, Campus Box 52, PO Box
173362, Denver, CO 80217-3362, mkettere@msudenver.edu
Saturday, January 9, 1 pm
SA-01 Elemental Testing in Toxicology Using ICP-MS, Frederick Strathmann and Christian Law, ARUP Laboratories,
500 Chipeta Way, Salt Lake City, UT 84108, frederick.g.strathmann@aruplab.com
SA-08 USP <232> and <233> and ICH-Q3D: Next Steps and Compliance, Nancy Lewen, BMS, 1 Squibb Dr., New
2016 Short Course Program and Abstracts
Page 3
2016 Winter Conference Short Courses
Brunswick, NJ 08903, nancy.lewen@bms.com
SI-07 ICP-MS II: Advanced Topics, John Olesik, Ohio State University, School of Earth Sciences, 125 S. Oval Mall, 026
Mendenhall Labs, Columbus, OH 43210-1002, olesik.2@osu.edu
ST-11 Uncertainty Budget Cookbook – Ready to Serve, Thomas Prohaska, University of Natural Resources and Life
Sciences, Department of Chemistry, VIRIS Laboratory, Konrad, Lorenz Strasse 24, A-3430 Tulin, Austria,
thomas.prohaska@boku.ac.at
ST-12 ETV-AAS, ICP-AES/ICP-OES, Quadrupole and Sector Field ICP-MS Method Development Problem Solving,
R. Steven Pappas and Mark R. Fresquez, Centers for Disease Control and Prevention, 4770 Buford Hwy, MS F-44,
Atlanta, GA 30341-3717, rpappas@cdc.gov
TS-01 Measurement of Size, Shape and Density of Nanoparticles Using Centrifugal Field-Flow Fractionation and a
Multi Detection System, Soheyl Tadjiki, Postnova Analytics, Inc., Salt Lake City, UT84102, soheyl.tadjiki@postnova.com
Saturday, January 9, 7 pm
SA-07 ICPMS for the Characterization of Nanomaterials: Focusing on the Exposure to Nanoproducts, Petra
Krystek, Institute for Environmental Studies (IVM), VU University Amsterdam, De Boelelaan 1087, NL-1081 HV
Amsterdam, The Netherlands, petra.krystek@ivm.vu.nl
SI-10 Identification and Correction of Interferences in Practical ICP-OES, Deborah Bradshaw, Atomic Spectroscopy
Consulting, PO Box 536307, Orlando, FL 32853-6307, bradshawdk@cs.com
SI-12 Direct Analysis with Ambient Mass Spectrometry: Chemical Analysis of Things as They Are, Jacob Shelley,
Kent State University, Department of Chemistry, 214 Williams Hall, Kent, OH 44242, jshelley@kent.edu, and Carsten
Engelhard, University of Siegen, Department of Chemistry & Biology, Analytical Chemistry, D-57076 Siegen, Germany,
engelhard@chemie.uni-siegen.de
ST-04 Environmental Forensics: ICPMS-Based Isotopic Methods, Michael Ketterer, Department of Chemistry and
Biochemistry, Metropolitan State University of Denver, Campus Box 52, PO Box 173362, Denver, CO 80217-3362,
mkettere@msudenver.edu
ST-10 Plasma Diagnostics: Fundamentals, Measurements, and Applications, Igor B. Gornushkin, BAM, Federal
Institute for Materials Research and Testing, Berlin, Germany, igor.gornushkin@bam.de
Sunday, January 10, 8 am
SA-02 ICP-MS and ICP-MS/MS: Critical New Tools for Clinical and Biological Studies, Julio Landero-Figueroa,
Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221-0172, julio_landero80@yahoo.com
SI-01 Calibration, Optimization, and Interferences in Plasma Spectrochemical Analysis, José A.C. Broekaert,
Institute for Inorganic and Applied Chemistry, University of Hamburg, Martin-Luther-King-Platz 6, D-20146 Hamburg,
Germany, jose.broekaert@chemie.uni-hamburg.de
SI-05 Time-of-Flight and Distance-of-Flight Mass Spectrometry for Elemental, Speciation, and Metallomic
Analysis, Steven J. Ray and Gary M. Hieftje, Indiana University, Department of Chemistry, 800 E. Kirkwood Ave.,
Bloomington IN 47405-7102, sjray@indiana.edu, hieftje@indiana.edu
ST-02 Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) Using Isotope Dilution (ID): Fundamentals and
Applications to Elemental and Elemental Species Analysis, Jörg Bettmer and Maria Montes-Baryon, Universidad de
Oviedo, Departamento de Química Física y Analítica, C/ Julián Clavería 8, E-33013 Oviedo, Spain,
bettmerjorg@uniovi.es, montesmaria@uniovi.es
ST-07 Adjusting Your Laboratory for Trace Analyses, Ela Bakowska, Elba Elemental Consulting, PO Box 1050,
Corning, NY 14830, ela_bakowska@yahoo.com
ST-09 Microwave-Assisted Sample Preparation for Spectrochemistry, Joaquim A. Nóbrega, Federal University of
São Carlos, Department of Chemistry, São Carlos, SP, Brazil, djan@terra.com.br
ST-15 Atomic Spectroscopy for Forensic Applications, Suresh Kumar Aggarwal, 1006, Sunflower, Neelkanth
Gardens, Govandi-East, Mumbai 400088, India, skaggr2002@gmail.com
Sunday, January 10, 1 pm
SA-05 Clinical ICP-MS I, Kathleen L. Caldwell, klc7@cdc.gov, and Cynthia Ward, dmo9@cdc.gov, 4770 Buford Highway,
Mailstop F-18, Atlanta, GA 30341-3724
SI-04 Opportunities, Challenges, and Application of Glow Discharge Techniques, Volker Hoffmann, Leibniz Institute
for Solid State and Materials, Research Dresden, PO Box 27 00 16, D-01171 Dresden, Germany, v.hoffmann@ifwdresden.de; Cornel Venzago, AQura GmbH, Postcode 915-d115, Rodenbacher Chaussee 4, 63457 Hanau-Wolfgang,
Germany, cornel.venzago@aqura.de
SI-08 Theory and Practical Use of Reaction Cells and Collision Cells for ICP-MS, John Olesik, Ohio State University,
School of Earth Sciences 125 S. Oval Mall, 026 Mendenhall Labs, Columbus, OH 43210-1002, olesik.2@osu.edu
2016 Short Course Program and Abstracts
Page 4
2016 Winter Conference Short Courses
SS-01 A Practical Guide to Nebulizers and the Part They Play in Modern Sample Introduction, Gerhard Meyer,
Promerus LLC, 9921 Brecksville Rd., Breckville, OH 44141, gary.meyer@promerus.com, and Geoff Coleman, Meinhard,
700 Corporate Circle, Golden, CO 80401-5636, gcoleman@meinhard.com
ST-06 Contamination Control for Trace Element Analysis, Brad McKelvey, Seastar Chemicals Inc., MV Laboratories,
10005 McDonald Park Rd., Sidney, BC V8L 5Y2, Canada, bmckelvey@seastarchemicals.com
ST-13 Sample Preparation Problem Solving for Atomic Mass Spectrometry, R. Steven Pappas and Naudia Gray,
Centers for Disease Control and Prevention, 4770 Buford Hwy NE, MS F44, Bldg 110, Atlanta, GA 30341-3717,
rpappas@cdc.gov
ST-14 Validation Assessment, Rob Ritsema, National Institute for Public Health and the Environment (RIVM), PO Box 1,
3720 BA Bilthoven, The Netherlands, rob.ritsema@rivm.nl; Petra Krystek, Institute for Environmental Studies (IVM), VU
University Amsterdam, De Boelelaan 1087, NL-1081 HV Amsterdam, The Netherlands, petra.krystek@ivm.vu.nl
Sunday, January 10, 7 pm
SA-04 Arsenic and Mercury Speciation in Biological Samples, Jörg Feldmann and Eva Krupp, University of
Aberdeen, College of Physical Sciences, Department of Chemistry, Trace Element Speciation Laboratory, Aberdeen
AB24 3UE Scotland, United Kingdom, j.feldmann@abdn.ac.uk, e.krupp@abdn.ac.uk
SA-06 Clinical ICP-MS II, Responding to Inorganic Chemical Exposure Evaluations and Emergency Response,
Robert Jones, Kathleen L. Caldwell, 4770 Buford Hwy, Mailstop F-50, Atlanta, GA 30341-3724, rljones@cdc.gov,
klc7@cdc.gov
SA-09 Analysis of Petroleum and Petroleum Products, José Luis Todolí, Department of Analytical Chemistry, Nutrition
and Food Sciences, University of Alicante, PO Box 99, 03080 Alicante, Spain, jose.todoli@ua.es
SI-03 High-Resolution ICP-MS, Norbert Jakubowski, BAM, Federal Institute for Materials Research, Richard-WillstätterStrasse11, 12498 Berlin, Germany, norbert.jakubowski@bam.de
SI-11 Identification and Correction of Interferences in Practical ICP-MS, Deborah Bradshaw, Atomic Spectroscopy
Consulting, PO Box 536307, Orlando, FL 32853-6307, bradshawdk@cs.com
SS-05 Laser-Induced Breakdown Spectroscopy (LIBS), Nicoló Omenetto, University of Florida, Department of
Chemistry, Gainesville FL 32611, omenetto@chem.ufl.edu
SS-07 Traditional vs. Specialized Sample Introduction Systems for ICP-AES and MS. Saturday, January 9, 7 pm,
Vassili
Karanassios,
University of
Waterloo,
Department
of
Chemistry,
Waterloo,
ON,
Canada,
vkaranassios@uwaterloo.ca
Monday, January 11, 7 pm
SA-03 Speciation Analysis: Complementarity of Elemental, Isotopic and Molecular Mass Spectrometry in
Environmental and Life Sciences. Joanna Szpunar, Laboratoire de Chimie Analytique Bio-inorganique et
Environnement, CNRS UMR 5254-IPREM, Hélioparc, 2, Av. Président Angot, 64053 Pau, France, joanna.szpunar@univpau.fr
SI-09 Understanding and Overcoming Matrix Effects in ICP-OES and ICP-MS, José Luis Todolí, Department of
Analytical Chemistry, Nutrition and Food Sciences, University of Alicante, PO Box 99, 03080 Alicante, Spain,
jose.todoli@ua.es
SS-04 Laser Ablation Fundamentals, Applications, and Directions, Jhanis Gonzalez, Applied Spectra, Inc., 46661
Fremont Blvd, Fremont, CA 94538, jhanis@appliedspectra.com, jjgonzalez@lbl.gov; Rick Russo, Lawrence Berkeley
National Laboratory, 1 Cyclotron Rd, Berkeley, CA 94720, rerusso@lbl.gov
ST-05 Tracing Element Metabolism in Animals and Humans Using Stable Isotope Techniques, Thomas Walczyk,
Department of Chemistry, National University of Singapore, Science Drive 4, Singapore 117543, walczyk@nus.edu.sg
ST-08 Clean Microwave Digestions for Ultra-Trace Analysis, Joaquim A. Nóbrega, Federal University of São Carlos,
Department of Chemistry, São Carlos, SP, Brazil, djan@terra.com.br
ST-16 Field-Flow Fractionation in Hyphenated Techniques: Measurement Quality Control and Applications in
Healthcare and Environmental Safety, Monday, Heidi Goenaga-Infante, LGC Limited, Queens Rd, Teddington,
Middlesex TW11 OLY, UK, heidi.goenaga-infante@lgcgroup.com
2016 Short Course Program and Abstracts
Page 5
2016 Winter Conference Short Courses
2016 Winter Conference Short Courses
Friday, January 8 - Monday, January 11, 2016
Descriptive Abstracts
Analysis by Plasma Spectrochemistry
SA-01 Elemental Testing in Toxicology Using ICP-MS, Saturday, January 9, 1 pm, Frederick Strathmann and Christian
Law, ARUP Laboratories, 500 Chipeta Way, Salt Lake City, UT 84108, frederick.g.strathmann@aruplab.com
This course will provide an overview regarding the use of ICP-MS in clinical toxicology. A discussion of the typical test
menu and design will include a review of what types of specimens are used and when, clinical presentations associated
with toxic exposure, and evolving areas of elemental toxicology including speciation techniques. Attention will be given to
optimizing approaches to calibration, quality control, and workflow unique to clinical toxicology. Challenges in elemental
clinical toxicology testing will be discussed including an enhancement of throughput using automation, integrating
autosamplers designed for low volume consumption, and opportunities for reducing operations costs throughout the
laboratory. The course is designed for laboratory supervisors, laboratory technologists, researchers, and medical
directors.
Keywords: ICP-MS, toxicology, work flow, quality control, test menu design, clinical presentation
Frederick Strathmann is a medical director of Toxicology at ARUP Laboratories and a tenure track assistant professor of
Pathology at the University of Utah where he oversees clinical testing for the Trace and Toxic Elements and Clinical
Toxicology Laboratories. He received his MS and PhD in Pathology and Laboratory Medicine from the University of
Rochester and completed a clinical chemistry fellowship at the University of Washington in Seattle. His current, scholarly
emphasis is on glial activation in traumatic brain injury and the assessment of metalloproteins in the response to CNS
trauma. Dr. Strathmann was a travel award recipient to the 2010 and 2013 MSACL conferences and was awarded the
Strandjord-Clayson Award for Meritorious Research from the Department of Laboratory Medicine at the University of
Washington in 2010, the Paul E. Strandjord Young Investigator Award from the Academy of Clinical Physicians and
Scientists in 2010 and 2011 and the Young Clinical Scientist Award (Technology Development) from ACS in 2013. He is
board certified in both clinical chemistry and toxicological chemistry by the American Board of Clinical Chemistry where he
currently serves on the Board of Directors.
Christian Law is the current Technical Supervisor of the Trace and Toxic Elements Laboratory at ARUP Laboratories. He
received his Bachelors of Science in Medical Laboratory Science at the University of Utah. Afterward he began his career
at ARUP Laboratories as a generalist in the University of Utah Hospital Clinical Laboratory. He has progressed through
several positions of increasing responsibility over his tenure at ARUP, including the technical supervisor of the Molecular
Amplified Detection Laboratory for seven years before moving to his current area of responsibility.
SA-02 ICP-MS and ICP-MS/MS: Critical New Tools for Clinical and Biological Studies, Sunday, January 10, 8 am,
Julio Landero-Figueroa, Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221-0172,
julio_landero80@yahoo.com
ICP-MS has been used for multiple years in clinical and biological studies and, in particular, of relatively simple total trace
metal analyses. However, more complex studies involving speciation, metabolomics, proteomics, etc. have received little
attention. But now with the advanced collision/reaction cell options and MS/MS detection, we are better able to address
more difficult problems in these areas. This short course will cover the basic principles affording us these opportunities
from sample preparations, advanced separation techniques and the major openings to the bio- and clinical- worlds
through P, S, and metal isotope detection at exceptional low levels without use of radioactive isotopes. Illustrative
applications will include ion channel studies, Zn and Cu detection for unraveling immune response mechanisms, toxicity
mitigation by selenium in arsenic and mercury situations, as well as others as time permits. Those individuals who have
trace metal analysis interests in more complex samples and beyond just total metals analysis will find this course
informative and very useful on a practical basis for clinical and biological sample types.
Keywords: ICP-MS, biomonitoring, trace element analysis, metal isotopes
SA-03 Speciation Analysis: Complementarity of Elemental, Isotopic and Molecular Mass Spectrometry in
Environmental and Life Sciences. Monday, January 11, 7 pm, Joanna Szpunar, Laboratoire de Chimie Analytique Bioinorganique et Environnement, CNRS UMR 5254-IPREM, Hélioparc, 2, Av. Président Angot, 64053 Pau, France,
joanna.szpunar@univ-pau.fr
The development of trace inorganic analysis was a response to the increasing concerns about the role of chemical
elements, even when present at low concentrations, in the environment and living organisms. The classical approach
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providing information on the total element concentration in a bulk sample has been giving way to finer approaches
including trace element spatial (imaging), isotope or molecular resolution (speciation). In recent years, each of these
approaches has grown into a separate field with a number of specific applications. The short course lecture will address
the complementarity of elemental, isotopic and molecular information to study the status, pathways and transformations of
trace elements in the environment and life sciences. The topics discussed will include:
(a) Speciation analysis and coupled techniques: the concept of elemental speciation, the occurrence and classification of
metal and metalloid species, the techniques used, the criteria of choice of a method for speciation analysis;
(b) ICP MS detection in chromatography; ICP MS-assisted proteomics;
(c) Electrospray MS in speciation analysis (de novo identification of organometallic species, characterization of metal
complexes with peptides and proteins);
(d) Complementarity of ICP and MALDI MS in bioimaging;
(e) The potential of stable isotope labels and isotope ratio determination Selected case studies.
Keywords: ICP-MS, speciation, coupled techniques, metal isotopes
Joanna Szpunar is research engineer at the French National Research Council (CNRS) in Pau, France. She has a broad
experience in the field of bio-inorganic speciation analysis with a focus on the identification and quantification of trace
elements in biological systems and in the chemistry of metal-biomolecule interactions. She is the author or co-author of a
book and more than 130 scientific publications in peer-reviewed international journals. Her works have received more
than 5500 citations ( h-factor 51). Dr. Szpunar (fellow of RSC) has given 30 invited lectures and is a member Advisory
Boards of JAAS, Metallomics and Brazilian Journal of Analytical Chemistry. The investigations carried out under her
supervision and/or with her active participation resulted in the identification of molecular targets of metals in biological
systems including, among others, Bi-binding proteins in Helicobacter pylori, Cd-metallothionein complexes in kidney cell
lines upon exposure to CdS nanoparticles, I-contaning protein in algae as well as selenoproteins in bacteria and plants.
Her research involves several collaboration projects (University of Zaragoza (Spain), Italian National Institute of Health,
University of Vigo (Spain), University of Santiago de Compostela (Spain), University of Naples (Italy), the Norwegian
University of Life Sciences, Hong Kong University, and Mahidol University (Thailand) laboratories. She has supervised six
PhD theses and several post-doctoral fellows.
SA-04 Arsenic and Mercury Speciation in Biological Samples, Sunday, January 10, 7 pm, Jörg Feldmann and Eva
Krupp, University of Aberdeen, College of Physical Sciences, Department of Chemistry, Trace Element Speciation
Laboratory, Aberdeen AB24 3UE Scotland, United Kingdom, j.feldmann@abdn.ac.uk, e.krupp@abdn.ac.uk
This course is divided into three parts. Part 1 shows how speciation analysis is done when only an element-selective
detector is available. In particular identification strategies of known and unknown species using HPLC-ICP-MS will be
elaborated. Part 2 introduces electrospray mass spectrometry and discusses the advantages and limitation of this
technique for complex sample matrices. Part 3 focuses on quantitative aspects in element speciation analysis when
chromatographic separations are used.
Keywords: Electrospray MS, ICP-MS, food analysis, arsenic, arsenosugars, mercury, phytochelatins, plant physiology
Jörg Feldmann received his PhD at University of Essen (Germany) in 1995; he studied volatile metal and metalloids in
the environment by using GC-ICP-MS. He was Feodor Lynen Postdoc (Alexander von Humboldt) at University of British
Columbia, Canada in 1995-1997 when he investigated complimentary use of GC-MS and GC-ICP-MS for volatile tin,
antimony and bismuth compounds. Since 1997 he was a Lecturer at University of Aberdeen, Scotland and became full
Professor in 2003. He has published more than 100 papers in peer-reviewed journals mainly about arsenic speciation. His
focus is on the determination of the arsenosugar metabolism by seaweed-eating sheep and the transport and
biotransformation of arsenic in plants and the pro and cons of ES-MS and ICP-MS and the online combination of both MS
techniques
SA-05 Clinical ICP-MS I, Sunday, January 10, 1 pm, Kathleen L. Caldwell, klc7@cdc.gov, and Cynthia Ward,
dmo9@cdc.gov, 4770 Buford Highway, Mailstop F-18, Atlanta, GA 30341-3724
Successful clinical ICP-MS is built upon a foundation of essential fundamentals. Topics that will be discussed include
selection of sample matrix, sample collection, transportation, and storage. We will also discuss in detail, analytical method
validation, limits of detection, long term QC material preparation and characterization, essential quality control measures,
ongoing quality assurance and human subject issues. We will also discuss how these analytical methods have been used
to respond to suspected community exposures to toxic metals and accidental exposure incidents and how your laboratory
can possibly work with the Public Health system to investigate local suspected exposure issues.
Keywords: Clinical, ICP-MS, QC\QA, LOD, biomonitoring, public health
Kathleen L. Caldwell is Deputy Branch Chief of the Inorganic and Radiation Analytical Toxicology Branch. Her
responsibilities include the planning, implementation, oversight, and completion of programs related to public health that
involves non-radioactive and radioactive elements or their isotopes. These programs involve research and development of
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a wide variety of analytical methods to enable the Centers for Disease Control and Prevention to assay and monitor the
exposure of populations to toxic or essential elemental exposures. Her other responsibilities include the implementation
and laboratory aspects of multiple local, state, regional, national and international studies or investigations. In addition, the
laboratory group responds to EPI Aids, “emergency responses” and is involved with terrorism preparedness.
Cynthia Ward is Chief of the Speciation and Lot Screening Laboratories. Her responsibilities include the planning,
implementation, oversight, and completion of programs implementation, oversight, and completion of laboratory speciation
programs related to public health that involves possible exposures to non-radioactive elements or elemental species.
These programs involve research and development of a wide variety of analytical methods to enable the Centers for
Disease Control and Prevention to assay and monitor the exposure of populations to toxic or essential elemental
exposures. Her other responsibilities include the implementation and laboratory aspects of multiple local, state, regional,
national and international studies or investigations.
SA-06 Clinical ICP-MS II, Responding to Inorganic Chemical Exposure Evaluations and Emergency Response.
Sunday, January 10, 7 pm, Robert Jones, rljones@cdc.gov, Kathleen L. Caldwell, klc7@cdc.gov, 4770 Buford Highway,
Mailstop F-50, Atlanta, GA 30341-3724
Clinical ICP-MS methods may be utilized for biomonitoring, emergency and chemical terrorism response to accidental or
intentional incidents. There are critical issues the lab must consider when preparing for both biomonitoring and emergency
response. Considerations include: laboratory infrastructure, personnel, sample logistics, supplies, instrument usage, QC
review, reporting data, and ability to exercise the whole response system. During this course, we will review several CDC
analytical methods utilized for biomonitoring, emergency response and chemical terrorism preparedness. In addition we
will discuss all of the critical issues listed above and issues that could severely limit your ability to effectively respond to a
large scale emergency.
Keywords: Clinical ICP-MS, emergency response, biomonitoring, and elemental speciation
Robert L. Jones is Chief of the Inorganic and Radiation Analytical Toxicology Branch. His responsibilities include the
planning, implementation, oversight, and completion of laboratory programs related to public health that involves possible
exposures to non-radioactive and radioactive elements or their isotopes. These programs involve research and
development of a wide variety of analytical methods to enable the Centers for Disease Control and Prevention to assay
and monitor the exposure of populations to toxic or essential elemental or radioactive exposures. In addition, the
laboratory group responds to Epidemiological (EPI) Aids, “emergency responses”, and is involved with inorganic and
radiological laboratory terrorism preparedness.
SA-07 ICPMS for the Characterization of Nanomaterials: Focusing on the Exposure to Nanoproducts, Saturday,
January 9, 7 pm, Petra Krystek, Institute for Environmental Studies (IVM), VU University Amsterdam, De Boelelaan 1087,
NL-1081 HV Amsterdam, The Netherlands, petra.krystek@ivm.vu.nl
This course will provide an overview about the role of ICPMS in the characterization of (engineered) nanomaterials and in
the analysis of (contact) matrices from human exposure scenarios to nanoproducts. The stepwise procedures from
sampling, sample pre-treatment and measurements by ICPMS will be discussed while aspects of validation and quality
control also will be involved. In these cases, ICPMS is used for elemental identification and quantification. The possibilities
by single particle (sp) ICPMS will be described as well.
While exposure can occur by inhalation, ingestion, injection and/or skin contact, the knowledge on exposure and possible
toxicity of nanotechnological products is still limited, resulting in a great relevance of human risk assessments. For
answering these questions, an integrated approach is needed based on the use of ICPMS along with hyphenated to
asymmetric flow field flow fractionation (AF4), for example, and other complementary techniques. An overview about the
selection criteria of matrices and analytical procedures by ICPMS will be given. Examples with body fluids, saliva, tissues
(organs) and skin will be discussed in detail.
Keywords: Nanoparticles, exposure, ICPMS, risk assessment
Petra Krystek received her PhD in 1999 at the University of Mainz, Germany. She has more than 18 years experience in
the field of ICPMS. Her research is strongly application focused, especially regarding to ultra-trace and speciation analysis
mainly in the field of health and environmental aspects, and she has been involved in many interdisciplinary projects.
From 2001 to 2006 she was working as scientist and department head at the National Institute for Public Health and the
Environment (RIVM) in The Netherlands. For several years she has been working at Philips, The Netherlands, and since
2009, she is a visiting scientist at the Institute for Environmental Studies (IVM) at the VU University Amsterdam, The
Netherlands. Since 2003 she has been a freelance assessor in inorganic analytical chemistry at the Dutch Accreditation
Council (RvA) for auditing laboratories in the Netherlands, for auditing laboratories in the Netherlands, which are
accredited according to ISO 17025. For several years she has been an invited lecturer for elemental analysis at Technical
University of Eindhoven, The Netherlands, and at the Centre of Expertise Analytical Sciences, The Netherlands. She is
board member of the working group Atomic Spectrometry and of the section Analytical Chemistry both of the Royal
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Netherlands Chemical Society (KNCV). Within her international network she is expert in the working group for ICP
spectrometry of the European Pharmacopoeia Commission (EDQM). She is experienced in the field of the analysis and
the monitoring of (ultra)trace metals in all kind of environmental and biological matrices. In addition, she is experienced in
the use of hyphenated techniques (e.g., LA-ICPMS, FFF-ICPMS, LC-ICPMS, and GC-ICPMS for speciation analysis). Her
current research interests are focused on risk assessment and biodistribution studies of engineered nanoparticles.
SA-08 USP <232> and <233> and ICH-Q3D: Next Steps and Compliance, Saturday, January 9, 1 pm, Nancy Lewen,
BMS, 1 Squibb Dr., New Brunswick, NJ 08903, nancy.lewen@bms.com
As ICH and USP take steps to finalize requirements that require compliance with elemental impurity limits, the
pharmaceutical industry will need to be able to demonstrate that compliance. This course will cover the USP and ICH
requirements for testing pharmaceuticals for element impurities, how to develop/validate methods, the concepts of risk
assessment and risk –based approaches, and helpful hints on analytical work and documentation.
Keywords: Elemental impurities, pharmaceuticals, ICH-Q3D, USP, <232>, <233>
Nancy Lewen has over 26 years’ experience in the pharmaceutical industry and is the supervisor of the Atomic
Spectroscopy Laboratory in Analytical R&D at Bristol-Myers Squibb. Nancy has served as a USP volunteer for over 10
years, having chaired the Elemental Impurities Advisory Panel and the <191>--Identity Tests sub-committee. She has also
served on the Spectroscopy and Water sub-committees. Her work focuses heavily on the use of the techniques of atomic
spectroscopy to solve analytical problems in the pharmaceutical industry, and also includes the use of XRF for use as a
rapid screening technique for process development work.
Nancy has written papers and lectured on the subject of pharmaceutical applications of atomic spectroscopy, and has
taught several short courses on that subject, as well. Nancy is the recipient of the 2008 New Jersey Association of
Biomedical Research “Outstanding Women of Science” award, the Bristol-Myers Squibb 2005 Chemistry Leadership
Award and the 2014, USP Award for “An Innovative Response to a Public Health Challenge” as a member of the USP
Elemental Impurities Advisory Panel.
SA-09 Analysis of Petroleum and Petroleum Products, Sunday, January 10, 7 pm, José Luis Todolí, Department of
Analytical Chemistry, Nutrition and Food Sciences, University of Alicante, PO Box 99, 03080 Alicante, Spain,
jose.todoli@ua.es
This course will provide an overview of the analysis of petroleum and petrochemicals by ICP OES and ICP-MS techniques
and, in depth, information on specific applications and challenges. Sample types will include crude oil, distillate fractions,
volatile hydrocarbons and solvents, used oils and other materials found in petrochemical processing. Sample preparation
and sample introduction will be highlighted. Existing methods, calibration standards, and certified samples will be
evaluated, as well as result validation and quality. The advantages of ICP-MS hyphenation with separation techniques will
be discussed. Time for class discussion on topics of individual interest will be provided, and advice will be available on
carrying out the ICP-OES and ICP-MS analysis of different petroleum products.
Keywords: ICP OES, ICPMS, plasma spectrometry, petroleum, crude oil, metals, organic solvents, sample preparation,
sample introduction, HPLC
Spectrochemical Instrumentation
SI-01 Calibration, Optimization, and Interferences in Plasma Spectrochemical Analysis, Sunday, January 10, 8 am,
José A.C. Broekaert, Institute for Inorganic and Applied Chemistry, University of Hamburg, Martin-Luther-King-Platz 6, D20146 Hamburg, Germany, jose.broekaert@chemie.uni-hamburg.de
The calibration and the statistical evaluation of data in plasma spectrochemical analysis are treated, including calibration
with external standards, detection/determination limits, signal-to-noise considerations, calibration by standard addition and
the use of internal standards. The acquisition of the spectral background and the concept of traceability will be covered.
Methods for optimization (trial-and-error, Simplex) and chemometrics (data display, multivariate analysis and clustering)
will be discussed as well as strategies for high-precision analysis. The topics of matrix induced signal enhancements and
depressions are treated. Examples from ICP-AES/MS with solutions, slurry nebulization lCP-AES, ETV-ICP-AES/MS,
microwave plasma-AES, glow discharge and speciation work will be given.
Keywords: Calibration, statistical evaluation, figures of merit, detection limits, interferences, data treatment, optimization,
high-precision analysis
José A.C. Broekaert received his Ph.D. in chemistry at University of Gent (Belgium) in 1976; he was an Alexander-vonHumboldt Research Fellow Germany (1977), and a scientist at ISAS - Leibnitz Institut für Analytische Wissenschaften,
Dortmund, Germany from 1978 to 1991. He became Associate Professor of Analytical Chemistry at University of
Dortmund (1991-1998), Professor of Analytical Chemistry at University of Leipzig (1998-2002) and subsequently at
University of Hamburg (since 2002). He was a Visiting Fulbright Research Fellow at Indiana University, Bloomington
(1998), and is an Adjunct Professor of Chemistry at Indiana University (since 2004). He is a Fellow of the Society for
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Applied Spectroscopy (since 2008), and an Ordinary member of the European Academy of Sciences and Arts (since
2014). His research interests include analytical chemistry especially with atomic spectrometric methods.
SI-02 Quantifying Complex Nanoparticles: Direct Coupling of Field Flow Fractionation with Single Particle
Inductively Coupled Plasma Mass Spectrometry, Saturday, January 9, 8 am, James F. Ranville, Colorado School of
Mines, Department of Chemistry and Geochemistry, Golden, CO 80401, jranvill@mines.edu; Chady Stephan,
PerkinElmer; Soheyl Tadjiki, Postnova Analytics
This course will outline a novel set of hyphenated analytical methods: field-flow fractionation (FFF) – inductively coupled
plasma mass spectrometry and single-particle ICP-MS (spICP-MS). The FFF-ICP-MS technique enables the
measurement of the elemental composition across the size distribution of particulate and macromolecular samples.
Particle-by-particle analysis of the FFF effluent by spICP-MS provides further particle characterization as well as providing
number concentrations. Thus the hyphenation of these two approaches yields size-based element speciation data
applicable to a wide range of samples and applications. The course will concentrate on the optimization of the FFF and
spICP-MS methods and will illustrate the detailed information that can be derived from the combined instruments. The
course will examine the choice of equipment and run conditions for a given sample and data analysis. Commercial
instrumentation should be available for demonstration. Conventional on-line and off-line detectors will be compared, and
ICP-MS with quadrupole and high-resolution instruments will be used to illustrate practical examples with biological,
environmental, geological samples, polymers, engineered nanomaterials, and other sample types.
Keywords: FFF, ICP-MS, nanomaterials, water, soils, sediments, particle sizing, elemental speciation
SI-03 High-Resolution ICP-MS, Sunday, January 10, 7 pm, Norbert Jakubowski, BAM, Federal Institute for Materials
Research, Richard-Willstätter-Strasse11, 12498 Berlin, Germany, norbert.jakubowski@bam.de
This course is an introduction to ICP-MS with a double focusing magnetic sector mass analyzer. It offers fundamental
background, a thorough discussion of analytical features, and state of the art information on applications. Different types
of double focusing instruments also are considered. Specific topics include fundamental aspects of ICP-MS (physical
properties of a double focusing instrument, operational characteristics in comparison with quadrupole instruments);
analytical characteristics (spectral and non-spectral interferences, figures of merit in low and high resolution modes,
blanks and memory effects, HPLC and GC interfaces), and applications (industrial including ultra-pure reagents and
alloys, environmental, geological, and biomedical materials).
Keywords: High-resolution ICP-MS, figures of merit, interfaces, applications, ultra-trace analysis
Norbert Jakubowski graduated as “Diplom-Physiker” from the University in Essen/Duisburg and obtained his doctorate
(Dr. rer. nat.) in 1991 from the University of Stuttgart/Hohenheim. In 1981 he joined the Institute for Analytical Sciences
(ISAS) in Dortmund to work as a research scientist in the laboratory for inorganic analysis. He became the head of the
division 1.1 (Inorganic Trace Analysis) of the Federal Institute of Materials Research and Testing in Berlin in 1999. His
present activities are mainly focused on analytical chemistry with special interest in development of instruments, methods
and problem-orientated procedures based on the use of plasma sources (inductively coupled plasma, glow discharge) for
elemental mass spectrometry of solid and liquid samples. Key Topics of his research include speciation of P, Pt, Gd;
metallomics; bioconjugation of antibodies for clinical assays; bio-imaging; analytical characterization of nanoparticles and
their interaction with cells.
SI-04 Opportunities, Challenges, and Application of Glow Discharge Techniques, Sunday, January 10, 1 pm, Volker
Hoffmann, Leibniz Institute for Solid State and Materials, Research Dresden, PO Box 27 00 16, D-01171 Dresden,
Germany, v.hoffmann@ifw-dresden.de; Cornel Venzago, AQura GmbH, Postcode 915-d115, Rodenbacher Chaussee 4,
63457 Hanau-Wolfgang, Germany, cornel.venzago@aqura.de
This course is designed to review the application of GD-OES and -MS in modern material science. Advantages and
disadvantages of the technique and different instruments will be discussed from practical point of view. Hard- and
software (quantification) will be explained, and applications will be compared with other methods of direct solids elemental
analysis. Analytical figures of merit for the two spectrometric methods will be presented. We offer all participants a
discussion about their actual analytical problems. Finally, the session will be concluded with a discussion of future trends
in instrumentation and applications, as e.g. imaging spectroscopy and ToF-MS.
Keywords: GD-OES, GD-MS, application, solid-state analysis
Volker Hoffmann graduated as “Diplom-Physiker” from the Technical University in Dresden and obtained his doctorate
(Dr. rer. nat.) in 1986. The same year he joined the Central Institute of Solid State Physics and Materials Research in
Dresden (now Leibniz Institute of Solid State and Materials Research) to work as a research scientist in the laboratory for
spectral analysis, where he became the head in 1996. His present activities are mainly focused on the research and
development of glow discharge optical (GD-OES) and mass spectrometry (GD-MS), which are performed in cooperation
with different companies and research groups in Europe and USA. In cooperation with LECO Germany and USA, a new
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radio frequency (rf) technology for the analysis of non-conductors by glow discharge spectroscopy was developed. In the
field of GD-MS he worked in joint cooperation together with PTB Braunschweig and developed a new fast flow source
principle, which after further development is now used in commercial GD-MS equipment. His present research includes
pulsed discharges to improve thin layer analysis and plasma imaging. From 2006 to 2012 he was chairman of the
European Working Group for Glow Discharge Spectroscopy, and he is secretary of the corresponding German workgroup.
Cornel Venzago graduated in 1986 from an engineering school in Winterthur, Switzerland with a degree in Chemistry.
The same year he joined a producer of high-purity metals for semiconductor industry, where he was responsible for
process and product development as well as for a solid-state mass spectrometry lab. In 1989 he joined the Institute of
Nuclear Physics at the University of Frankfurt, Germany and worked in a joint industry/university project on the
development for spark source mass spectrometry for ultratrace analyses in GaAs. In 1991 he joined Degussa AG in
Germany to start up a GD-MS lab. He is nowadays director of inorganic analyses at AQura GmbH covering the
techniques GD-MS, ICP-MS, ICP-OES, AAS, XRF, and many others. The company AQura is a subsidiary of Evonik
Industries (ex Degussa). In the field of GD-MS he has done and is doing still many instrument and method developments,
also under the frame of co-operations with instrument manufacturers.
SI-05 Time-of-Flight and Distance-of-Flight Mass Spectrometry for Elemental, Speciation, and Metallomic
Analysis, Sunday, January 10, 8 am, Steven J. Ray and Gary M. Hieftje, Indiana University, Department of Chemistry,
800 E. Kirkwood Ave., Bloomington IN 47405-7102, sjray@indiana.edu, hieftje@indiana.edu
The use of time-of-flight mass spectrometry (TOFMS) with atomic ionization sources offers unique capabilities and
formidable advantages, many of which have yet to be fully exploited. Here, plasma-source TOFMS is critically examined,
including basic theoretical concepts, critical instrumental components, commercial solutions, and aspects of analytical
performance. Applications from biology, clinical chemistry, geology, materials science that highlight the unique attributes
of plasma-source TOFMS are reviewed, with particular emphasis on the use of transient sample introduction sources
such as chromatography, single particle analysis, or laser-ablation. Finally, future developments are considered, including
distance-of-flight mass spectrometry and aspects of single-cell elemental analysis.
Keywords: Time-of-flight mass spectrometry, mass spectrometry, elemental speciation, ICP-MS, GD-MS, Distance-offlight mass spectrometry
Steven Ray is an Associate Scientist on the research faculty within the Department of Chemistry at Indiana University. He
has over 15 years experience in the design, construction, and use of time-of-flight mass spectrometers, with a particular
emphasis on their development for elemental ionization sources. Dr. Ray has coauthored over 40 papers, four book
chapters, holds four patents, and has presented numerous manuscripts at international conferences on elemental
TOFMS.
Gary M. Hieftje is Distinguished Professor and Mann Chair of Chemistry at Indiana University in Bloomington, Indiana.
He is reportedly “older than dirt” and pioneered the use of time-of-flight mass spectrometry with analytical plasma sources.
He has won numerous awards in the fields of analytical chemistry, chemical instrumentation, and spectroscopy, has held
major offices in several scientific societies, has delivered many named lectures, and has served on the editorial boards of
many major journals. He is the author of over 560 publications, 10 books, and 18 patents. More than 65 students have
received doctorates under his direction; many others have received M.S. degrees, and scores of undergraduates and
visiting scientists have performed research in his laboratories.
SI-06 ICP-MS I: Introduction, Saturday, January 9, 8 am, R. Sam Houk, Iowa State University, Ames Laboratory USDOE
Department of Chemistry, Ames, IA 50011, rshouk@iastate.edu
This course is intended mainly for the newcomer to ICP-MS. ICP characteristics as an ion source, ion extraction,
operating principles of ion optics, ion focusing, quadrupole and sector mass analysis, and detectors will be described. The
general analytical capabilities, applications survey, and an introduction to matrix effects will be presented.
Keywords: ICP-MS characteristics, instrumentation, interferences, applications
Robert Samuel Houk is Professor of Chemistry, Iowa State University, and Senior Chemist, Ames Laboratory USDOE.
He received a B.S. in 1974 at Slippery Rock State College and a Ph.D. in 1980 in analytical chemistry at Iowa State
University. He was a postdoctoral associate in 1981 at Ames Laboratory USDOE, where he joined the faculty as assistant
professor.
He has received the ACS Award for Spectrochemical Analysis (2011); Fellow, Society for Applied Spectroscopy (2007);
Anachem Award, Detroit MI (2000); Research Award, College of Liberal Arts & Sciences, ISU (2000); ACS Award for
Chemical Instrumentation (1993); Wilkinson Teaching Award, Department of Chemistry, Iowa State University (1993);
Maurice F. Hasler Award, Spectroscopy Society of Pittsburgh and Fisons (1993); Lester W. Strock Award, Society for
Applied Spectroscopy (1986). He is a member of Editorial Advisory Board of Spectrochimica Acta, Part B. His original
ICP-MS paper [R.S. Houk, V.A. Fassel, G.D. Flesch, H.J. Svec, A.L. Gray and C.E. Taylor, Inductively Coupled Argon
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Plasma as an Ion Source for Mass Spectrometric Determination of Trace Elements, Anal. Chem. 52, 2283-2289 (1980)]
was chosen to be “one of the 60 most influential papers published in the journal Analytical Chemistry," 1994.
SI-07 ICP-MS II: Advanced Topics, Saturday, January 9, 1 pm, John Olesik, Ohio State University, School of Earth
Sciences, 125 S. Oval Mall, 026 Mendenhall Labs, Columbus, OH 43210-1002, olesik.2@osu.edu
This course is intended for those who complete Part I and for the experienced ICP-MS user. Detailed consideration will be
given to basic cases of matrix effects, removal of polyatomic ion interferences (solvent removal, collisional dissociation,
high resolution, cool plasma), alternate mass analyzers, solid sampling, analysis of limited solution volumes, and
combining ICP-MS with chromatography for speciation and removal of interferences.
Keywords: ICP-MS operation and measurement effects, interference corrections, sampling, chromatography
SI-08 Theory and Practical Use of Reaction Cells and Collision Cells for ICP-MS, Sunday, January 10, 1 pm, John
Olesik, Ohio State University, School of Earth Sciences 125 S. Oval Mall, 026 Mendenhall Labs, Columbus, OH 432101002, olesik.2@osu.edu
The design and operation of reaction cells and collision cells used for isobaric interference removal in ICP-MS will be
discussed. The course begins with an introduction to the principals and kinetics of ion-molecule reactions and the
operation of the rf devices (quadrupoles, hexapoles, octapoles, etc.). The various efficiencies of the ion chemistry
(primarily ion reactivity, reactivity, production of the ions within the cell) will be evaluated, concluding that where high
efficiency of the primary chemistry is obtained, reaction of the analyte ion with impurities and the formation of new
interferences within the cell becomes important. Various means of suppressing these effects, including kinetic energy
discrimination and band pass operation of the cell will be contrasted and compared, and effects related to the order of the
multipole device will be considered. Examples of the application of reaction cell and collisions cell methods in the
semiconductor, environmental, clinical, geochemical, and isotopic analysis will be presented.
Keywords: Collision cell, reaction cell, spectral interference, chemical resolution, pressurized multipole, chemistry, ion
dynamics, ion-molecule chemistry, in-cell produced interferences, multipole operating point, energy discrimination
SI-09 Understanding and Overcoming Matrix Effects in ICP-OES and ICP-MS, Monday, January 11, 7 pm, José Luis
Todolí, Department of Analytical Chemistry, Nutrition and Food Sciences, University of Alicante, PO Box 99, 03080
Alicante, Spain, jose.todoli@ua.es
Matrix effects make difficult the use of ICP techniques for some particular applications. The first step to overcome them is
to understand the mechanisms and the main sources of interferences. The present course deals with the detection of the
origin of the ICP-OES and ICP-MS interferences. The discussions will be based on selected applications (clinical, organic,
food analysis…). Advice to improve the accuracy of the determinations will be given.
Keywords: Matrix effects, liquid sample introduction system, inorganic acids, organic solvents, easily ionized elements,
ICP-AES, ICP-MS
SI-10 Identification and Correction of Interferences in Practical ICP-OES, Saturday, January 9, 7 pm, Deborah
Bradshaw, Atomic Spectroscopy Consulting, PO Box 536307, Orlando, FL 32853-6307, bradshawdk@cs.com
The identification and correction of interferences for ICP-OES can be critical to obtain accurate data in the analytical
laboratory. The interferences and their corrective techniques that will be addressed include sample transport, sample
matrix, and spectral. Procedures used to correct for transport and matrix interferences include the use of appropriate
internal standards, matrix matching, optimizing plasma conditions, using buffer solutions, and the correct choice of sample
introduction systems. Spectral interference correction approaches include optimizing the method parameters as well as
choosing the appropriate correction technique such as interelement corrections and multiple linear regression techniques.
Some of these may be limited to the specific instrumental hardware and software available to the analyst. The merits and
disadvantages of the various correction approaches that are used will be examined, with practical examples of the use of
these corrections to obtain accurate data.
Keywords: Transport interferences, matrix interferences, spectral interferences, interelement correction, multiple linear
regressions, inductively coupled plasma atomic emission
SI-11 Identification and Correction of Interferences in Practical ICP-MS, Sunday, January 10, 7 pm, Deborah
Bradshaw, Atomic Spectroscopy Consulting, PO Box 536307, Orlando, FL 32853-6307, bradshawdk@cs.com
The identification and correction of interferences for ICP-MS can be critical to obtain accurate data in the analytical
laboratory. The interferences and their corrective techniques that will be addressed include sample transport, sample
matrix, and spectral. Procedures used to correct for transport and matrix interferences include the use of appropriate
internal standards, matrix matching, optimizing plasma conditions, and the correct choice of sample introduction systems.
Spectral interference correction approaches include optimizing the method parameters as well as choosing the
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appropriate correction equations. The merits and disadvantages of the various correction approaches that are used will be
examined, with practical examples of the use of these corrections to obtain accurate data.
Keywords: Transport interferences, matrix interferences, spectral interferences, correction equations, inductively coupled
plasma mass spectrometry
SI-12 Direct Analysis with Ambient Mass Spectrometry: Chemical Analysis of Things as They Are, Saturday,
January 9, 7 pm, Jacob Shelley, Kent State University, Department of Chemistry, 214 Williams Hall, Kent, OH 44242,
jshelley@kent.edu, and Carsten Engelhard, University of Siegen, Department of Chemistry & Biology, Analytical
Chemistry, D-57076 Siegen, Germany, engelhard@chemie.uni-siegen.de
The ultimate goal of analytical chemistry is to provide, what G.E.F. Lundell described as, “the chemical analysis of things
as they are” such that a comprehensive assessment of sample constituents is directly obtained in a way that is
nondestructive, while the sample is interrogated in its native environment. Recent efforts in mass spectrometry ionization
source development have demonstrated these attributes to be possible. In such ambient mass spectrometry experiments,
the source desorbs molecules from a surface, softly ionizes them, and transfers these ions into a mass spectrometer. This
course will cover fundamental principles of desorption/ionization processes, as well as applications of these ionization
sources. In this course a particular emphasis will be placed on plasma-based systems.
Keywords: Direct Analysis, mass spectrometry, DART, DESI, glow discharge, ambient ionization sources,
pharmaceutical analysis, homeland security
Jacob Shelley was born in Albuquerque, NM, and he earned his B.S. in Chemistry from Northern Arizona University in
Flagstaff, AZ in 2005. His research at NAU, while working under Diane Stearns, was focused on finding metal-DNA with
ICP-AES. He worked at Los Alamos National Laboratory for four summers on a wide range of projects including
metallomics with X-ray fluorescence detection, developing nanoporous silica substrates for matrix-free MALDI, and
method development for detecting a wide range of radioactive materials. He completed his Ph.D. in 2011 under Gary
Hieftje at Indiana University where his research focus was on the development, characterization, and application of novel
plasma ionization sources for ambient, molecular mass spectrometry with particular attention on the Flowing AtmosphericPressure Afterglow (FAPA) source. Jake was postdoctoral researcher with R. Graham Cooks from 2011 to 2012 at
Purdue University where he developed portable, miniature mass spectrometers capable of truly in situ analyses. In
September 2012 Jake started a post-doctoral position with Uwe Karst and Carsten Engelhard at the University of Münster.
He joined the faculty of Kent State in January 2014. His current research interests are in the area of fundamental
characterization of plasma-based ambient ionization sources, such as the FAPA and the low-temperature plasma probe,
and improving these sources to overcome problems with matrix effects and quantification. He has authored 20 journal
articles and two United States patents and has given more than 12 invited presentations at national and international
venues.
Carsten Engelhard was Born and raised in Siegen, Germany. He attended the University of Muenster (WWU), Germany,
from 1997-2003 before receiving his Diploma in Chemistry. At WWU he performed undergraduate research with Prof. Karl
Cammann and Dr. Wolfgang Buscher on developing instrumentation for electrothermal vaporization microwave induced
plasma optical emission spectrometry. His graduate studies were mainly focused on developing alternative, low-argonflow plasma sources for ICPs. In 2007 he received his Dr. rer. nat. degree majoring in analytical chemistry. Carsten then
performed his postdoctoral research with Gary Hieftje at Indiana University from 2008 to 2010. In the Hieftje laboratories,
he developed a large-format pulsed glow discharge instrument for imaging applications. Since May 2010 Carsten was a
faculty member at the University of Muenster, and since fall 2012 he holds a temporary lecturer position at the University
of Siegen. Research interests currently revolve around analytical chemistry with a special focus on methods for direct
analysis with ambient desorption/ ionization mass spectrometry; nanomaterials characterization; and fundamentals/
applications of ICP-MS.
Sample Introduction Approaches
SS-01 A Practical Guide to Nebulizers and the Part They Play in Modern Sample Introduction, Sunday, January 10,
1 pm, Gerhard Meyer, Promerus LLC, 9921 Brecksville Rd., Breckville, OH 44141, gary.meyer@promerus.com, and
Geoff Coleman, Meinhard, 700 Corporate Circle, Golden, CO 80401-5636, gcoleman@meinhard.com
This course will give participants an overview of the popular methods for introducing liquid samples used by today’s
instruments. A wide variety of nebulizers will be presented along with a discussion of how they work, which ones to use
for particular matrices, and how to properly care for them. Along the way we will also feature ideas for best connecting
pump tubing of a wide variety of sizes to these various devices. Once a firm understanding of nebulizers and their
operation is established, the course will continue with a detailed discussion of sample matrices, properties of aerosols and
segregation chambers that are important for good spectrochemical analysis, how matrices affect nebulizer performance
and what can be learned about these matrices from the spectroscopic results. Since nebulization implies working with
aerosols, participants will be provided a window into novel sample collection techniques that use nebulizers as part of the
whole sample introduction scheme. Engaging discussions among the participants will be encouraged, so that everyone
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can share their experiences and come away with new and practical information with which to return to the lab.
Keywords: Nebulizers, spray chambers, desolvation, aerosol diagnostics, process monitoring, transport efficiency
Gerhard Meyer is Chief Analyst at Promerus LLC, a subsidiary of Sumitomo Bakelite North America located in
Brecksville, Ohio, where he performs determinations of trace levels of impurities in high purity organic electronic materials
using ICPOES and ICPMS, as well as works in the area of thermal analysis and tensile testing. He received his PhD at
the University of Massachusetts – Amherst, and has worked at Dow Chemical Company, Battelle Memorial Institute,
Thermo Jarrell Ash, Ametek/EDAX, and The Ohio State University. His outside research interests include the application
of spectroscopic techniques to workplace air quality and hot fume emissions monitoring, and the design and manufacture
of aerosol particle extraction instruments.
SS-02 Laser Ablation Mass Spectrometry I, Friday, January 8 1 pm, Henry Longerich, Earth Sciences, Memorial
University of Newfoundland, St. John’s, NL A1B 3X5, Canada, henryl@mun.ca, and Detlef Günther, Laboratory of
Inorganic Chemistry, ETH Hönggerberg, HCI, G113, CH-8093, Zürich, Switzerland, guenther@inorg.chem.ethz.ch
The course is designed to give participants an introduction to the analytical capabilities of laser ablation - inductively
coupled plasma spectrometry and should be of particular benefit to spectroscopists interested in developing a laser
ablation facility. LA-ICP-MS has become one of the most common solid sampling technique for major, minor and trace
element analysis. The course will explain how LA-ICP-MS works. Details about basics in lasers and ICP-MS
instrumentation and their combination will be explained. Examples for transient data acquisition, method development,
and a large number of applications will be discussed to give a feel for the quantification capabilities of this analytical
technique. Topics also will include terms and terminology, laser selection, ablation cell design and interfacing, ablation
processes, transport phenomena, and measurement systems. Participants do not need previous knowledge about this
technique.
Keywords: Lasers, ablation, aerosol transport systems, carrier gas, calibration, atomization and ionization, ICP-MS,
interface, applications
Henry Longerich graduated from Indiana University with a PhD in Analytical Chemistry in 1967. He then joined the
chemistry faculty at the University of Alaska in Fairbanks, following which he did post doctoral research at Dalhousie
University in Halifax, Nova Scotia, Canada. Henry then moved to Memorial University of Newfoundland, where he is now
Professor Emeritus in the Department of Earth Sciences. He was responsible for the electron probe X-ray microanalysis
facility, X-ray fluorescence instrumentation, and development of computerization in the department. Henry became
involved with ICP-MS in 1984 when he installed an ELAN 250 instrument, which was the tenth ICP-MS instrument sold
and installed by Sciex. After several years of developing solution nebulization methods for geosciences and
environmental applications, the Memorial University research group obtained funding in 1988 to build a micro sampling
laser ablation (LA) system to use with the ICP-MS. The landmark 1992 LA paper (Jackson, Longerich, et. al, Canadian
Mineralogist, 30, 1049-1064), which received the Hawley Medal for the best paper of the year in the Canadian
Mineralogist, contributed significantly to the establishment of LA micro sampling in the earth sciences. It was clearly
shown in this paper that the 1064 nm Nd:YAG laser used was not optimum, especially for samples, which were
transparent at this wavelength. This paper suggested, “Use of different wavelengths of the laser can be expected to allow
further improvement ...”. This led to the development of a frequency quadrupled 266 nm system, and later in 1998 to the
publication of the first report using a quintupled 213 nm system (Jeffries, Jackson, and Longerich, JAAS, 13, 935-940). In
1996 he took voluntary early retirement from Memorial University, where he continues to supervise students and carry on
funded research. While not in residence in Newfoundland, he has become an “itinerant” professor, doing research and
teaching at the University of Alberta, Chemex Laboratories, St. Francis Xavier University, Trent University, and Clarion
University of Pennsylvania.
SS-03 Laser Ablation Mass Spectrometry II, Friday, January 8, 7 pm, Detlef Günther, Laboratory of Inorganic
Chemistry, ETH Hönggerberg, HCI, G113CH-8093, Zürich, Switzerland, guenther@inorg.chem.ethz.ch, and Henry
Longerich, Earth Sciences, Memorial University of Newfoundland, St. John’s, NL A1B 3X5, Canada, henryl@mun.ca
The course will provide detailed knowledge about recent instrumentation and method developments in LA-ICP-MS.
Various problems in laser sample interaction, aerosol transport, and atomization and ionization will be discussed.
Elemental fractionation, its source, and various strategies to overcome this problem for different laser and ICP-MS
systems will be extensively discussed. Furthermore, different quantification strategies and non-matrix matched calibration
examples will be given. A few non-routine applications will also be discussed. Participants should have some knowledge
or practical experience with LA-ICP-MS or should have taken the basic LA-ICP-MS course (SS-04).
Keywords: Laser-sample interaction, elemental fractionation, aerosol size and aerosol transport, atomization and
excitation, ICP-MS, interface and ICP-optimization
Detlef Günther was born in Köthen, Germany in 1963. He obtained his Diploma degree in Chemistry in 1987 and a Ph.D.
degree in Analytical Chemistry from the Martin-Luther-University Halle-Wittenberg under supervision of L. Moenke 2016 Short Course Program and Abstracts
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Blankenburg in 1990. After carrying out postdoctoral work in the Institute of Plant Biochemistry Halle where he worked on
the development of analytical methods to characterize heavy metal-binding proteins using HPLC-ICP-MS, he joined the
group of H.P. Longerich at the Memorial University of Newfoundland, Canada. From 1995 until 1998 he was in the group
of C.A. Heinrich at the Institute of Isotope Geology and Mineral Resources at ETH Zürich. In 1998 he was appointed
Assistant Professor in the Laboratory of Inorganic Chemistry at the ETH Zürich. He was promoted to Associate Professor
for Trace Element and Micro Analysis in 2003 and became Full Professor in 2008. From 2010 until 2012 he was Chair of
the Department of Chemistry and Applied Biosciences at ETH Zurich and since 2015 he is Vice President for Research
and Corporate Relations at ETH Zurich. He is recipient of the Ruzicka Award (2002), the European Award for Plasma
Spectrochemistry (2003), the Fresenius Award (2007), and the Lester Strock Award (2007), and he received in 2013 the
“Einstein Visiting Fellowship” to Humboldt University Berlin (Germany) and the “Thousand Talent Fellowship” (Wuhan
University, China). In 2014 he became a member of the German National Academy of Science Leopoldina. His research
program focuses on fundamental and applied studies in inductively coupled plasma-mass spectrometry (ICP-MS) and
laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS), including studies on laser- sample interaction,
aerosol transport, and plasma-related excitation processes. As well particle plasma interaction and particle vaporization
for single nanoparticle analysis have been studied. Fundamental processes of UV-ns and UV-fs laser ablation used with
Q-ICP-MS, SF-ICP-MS, TOF-ICP-MS, and MC-ICP-MS as well as alternative excitation sources, such as glow discharge
are currently under investigation. The improvements in trace element and microanalysis and isotope ratio determinations
have been demonstrated on a wide variety of applications (e.g., quantification of fluid inclusions, gemstones, metals,
minerals, ceramic, and various nano materials).
SS-04 Laser Ablation Fundamentals, Applications, and Directions, Monday, January 11, 7 pm, Jhanis Gonzalez,
Applied Spectra, Inc., 46661 Fremont Blvd, Fremont, CA 94538, jhanis@appliedspectra.com, jjgonzalez@lbl.gov; Rick
Russo, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, Berkeley, CA 94720, rerusso@lbl.gov
Laser ablation has advanced over the last 50 years to become a successful technology for numerous chemical analysis
applications. Breakthroughs in understanding the science of the ablation process and development of improved laser and
detector components have led to reliable analytical measurement performance. The course will summarize key underlying
mechanisms of the ablation process that are critical for accurate and precise measurements using LIBS and ICP-MS. This
course will cover state of art system and performance, example applications and directions for future capabilities.
Keywords: Laser ablation, ICP-MS, LIBS, chemical analysis, elemental isotopic and molecular analysis, nano-analysis,
imaging
Jhanis José González Chacon is director of Applications Lab Operations, Applied Spectra, Inc, Fremont, CA, and
project scientist at Lawrence Berkeley National Lab, Berkeley, CA. He received a BS and PhD in chemistry from Central
University of Venezuela, and he joined the Laser Spectroscopy and Applied Materials Group at Lawrence Berkeley
National Laboratory, under the supervision of Dr. Richard E. Russo. He was a postdoctoral fellow from 2004 to 2007. His
research is focused on fundamental mechanisms of laser-material interaction, including laser energy coupling to solid
samples, laser induced plasma properties, particle formation and transport, and developing new applications for laser
technologies, in particular laser induced breakdown spectroscopy (LIBS) and laser ablation inductively coupled plasma
mass spectroscopy (LA-ICP-MS).
Richard E. Russo is founder and scientific director of the laser material interactions group at the Lawrence Berkeley
National Laboratory (LBNL). His group has pioneered the development of laser ablation for chemical analysis, with an
almost 30 year contribution to fundamental and applied research topics. Programs in this group are closely integrated to
DOE basic science, industrial technologies and nonproliferation activities. His research has led to breakthroughs in laser
ablation understanding and development. Dr. Russo has an international scientific reputation in chemistry and physics
related to nanosecond and femtosecond laser-material-interactions (laser ablation), is co-inventor of the nanowire laser,
and developer of a real-time standoff laser ultrasonic sensor (R&D100 2006). He also is co-inventor of a process for ion
nano-texturing (ITEX) thin-films, lead-inventor of the ion-assisted pulsed laser deposition (IBAD) process, and a pioneer in
elucidating fundamental laser heating and laser ablation processes for chemical analysis. The group achieved 450 nm
spatial resolution and a detection limit of 220 ag using a single laser pulse for LIBS (laser induced breakdown
spectroscopy) measurements. By pioneering near-field scanning optical microscopy (NSOM) with laser ablation, the
group achieved 30-nm diameter sampling and analysis. Finally, the group demonstrated and patented the use of laser
plasmas (LIBS) for real-time measurement of isotopes. Russo has over 220 scientific publications; 45 refereed
proceedings; 250 (115 Invited) presentations, nine book chapters, and nine patents. Fourteen students have received
their PhD degree under his direction at the University of California, Berkeley.
Dr. Russo is president and founder of Applied Spectra, Inc. (ASI). The company is the world leader in laser ablation based
chemical analysis using LIBS and laser ablation with ICP-OES and ICP-MS. The ASI staff members are experts in
utilizing laser ablation for solving the most challenging chemical analysis problems. Applied Spectra’s LIBS and laser
ablation instruments offer superior performance in commercial, military, and security markets. These LIBS and LA-ICP2016 Short Course Program and Abstracts
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MS systems provide significant cost benefits to traditional chemical analysis, delivering real time elemental and isotopic
analysis with excellent spatial and depth resolution, and without sample digestion. The ASI bench top RT100 LIBS system
is successfully deployed in energy, environmental, health, industrial and security markets. The company continues to
drive laser ablation capabilities and instrumentation based on strong in-house research, and instrumentation and
applications (methods) development.
SS-05 Laser-Induced Breakdown Spectroscopy (LIBS), Sunday, January 10, 7 pm, Nicoló Omenetto, University of
Florida, Department of Chemistry, Gainesville FL 32611, omenetto@chem.ufl.edu
This course will cover the basic principles, mechanisms, and instrumentation of laser-induced breakdown spectroscopy
(LIBS).
Keywords: LIBS, atomic spectroscopy, mechanisms, instrumentation
Nicoló Omenetto is professor of chemistry at the University of Florida. His work in spectrochemistry began in 1964 with his
doctoral work at the University of Padova, and continued at the European Community Joint Research Centre at Ispra, and
the University of Florida. Nico’s research interests are the theory and applications of atomic and molecular spectroscopic
analysis methods with particular emphasis on use of tunable lasers and development of techniques including atomic and
molecular fluorescence, atomic ionization, photo-thermal, photo-fragmentation, and laser induced breakdown
spectroscopy. He has also investigated fundamental diagnostic studies in atom reservoirs such as flames and plasmas,
improving the characterization of the interaction between the laser and the atomic/molecular systems. The focus of his
recent research is the development of laser induced breakdown spectroscopy (LIBS) as a quantitative analytical method.
Applications have focused on environmentally important topics.
SS-06 Practical Applications of Laser-Induced Breakdown Spectroscopy (LIBS), Saturday, January 9, 8 am, Sharla
Woods, Bristol-Myers Squibb, 1 Squibb Drive, Mail Stop 107-1-1250, New Brunswick, NJ 08903,
Sharla.Woods@bms.com
Laser-induced breakdown spectroscopy (LIBS) has emerged as a unique analytical technique for the qualitative and
quantitative analysis of a variety of solid materials. The minimal sample preparation requirements, high spatial resolution
capabilities, rapid analysis time, simple instrumentation, and applicability to all media make LIBS especially appealing to
the pharmaceutical industry. This course will introduce the fundamentals and instrumentation of LIBS and provide a brief
review of current applications. The utility of LIBS for the analysis of solid materials, especially pharmaceutical samples,
will be covered; including its application to coating analysis, homogeneity determination, contaminant identification, and
elemental quantitative analysis.
Keywords: Pharmaceuticals, LIBS, atomic spectroscopy, solid analysis
Sharla Woods is a Research Investigator in the Atomic Spectroscopy group at Bristol-Myers Squibb in New Brunswick,
New Jersey. Her research concentrates on pharmaceutical applications of plasma-based analytical techniques, such as
ICP-AES, ICP-MS, LA-ICP-MS and LIBS. Specifically, she has worked on applying LIBS to a broad range of challenges
encountered in pharmaceutical formulations, including batch homogeneity determination, tablet coating analysis, particle
size investigations, and contaminant identification.
SS-07 Traditional vs. Specialized Sample Introduction Systems for ICP-AES and MS. Saturday, January 9, 7 pm,
Vassili Karanassios, University of Waterloo, Department of Chemistry, Waterloo, ON N2L 3G1, Canada,
vkaranassios@uwaterloo.ca
This course will provide a brief overview of traditional sample introduction systems (e.g., nebulizers) for ICP-AES and ICPMS (~15% of the time). Then, instrumentation requirements for acquisition of transient signals will be discussed.
Examples of specialized systems include (but are not limited to) hydride generation (e.g., for Hg determination), laser
ablation; sample introduction of individual particles, and electrothermal vaporization (ETV) approaches (~60% of the time).
For the remaining time, the focus will be on an ETV, near-torch vaporization (NTV) sample introduction system which, in
addition to improving detection limits of ICP-AES and of ICP-MS by a couple of orders-of-magnitude and to providing
micro-sample (e.g., Eu-tagged immunoassays) and nano-sample capabilities (e.g., individual vesicles), it can also be
used for taking part-of-the-lab to the sample types of applications and for speciation studies (e.g., Cr speciation in the field
and measurement in the lab).
Keywords: Sample introduction; hydride generation; laser ablation; ETV; NTV; micro- and nano-samples; Eu-tagged
immunoassays; Cr-speciation; field sampling
Vassili Karanassios is a Professor of Chemistry at the University of Waterloo and a co-founder of a degree-program in
nano-technology engineering. His interests are in the development of micro- and nano-sample introduction systems for
ICPs, and on development of micro- and nano-instruments for chemical. In 2009, he received an award from UK’s
Leverhulme Trust, and was a visiting Professor in the Department of Chemistry, the University of Sheffield (Sheffield, UK)
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and visiting Professor in Cambridge University (Cambridge, UK), in the Department of Electrical Engineering (the Center
for Advanced Photonics and Electronics).
Plasma Spectrochemical Techniques
ST-01 On-the-Job Skills for Technology Developers (Things You Were Not Taught in School), Saturday, January 9,
8 am, Andrew T. Zander, Consultant, Gerson Lehrman Group, 1632 Hickory Ave, Torrance, CA 90503,
atzander@earthlink.net; Megan Cotugno, The Rand Corporation, Santa Monica, CA
In this four-hour seminar-style short course, topics that technology developers need to succeed in their job will be
covered. Among the topics covered and that were mostly neglected or never covered in formal education programs for
chemists, physicists and engineers, will be (not inclusive): the workplace and work patterns in it; confidential documents;
credentials; project and program management; teaming; budgets and finances including the cost of RDT&E; personnel
management; innovation and why it is problematic; leadership in the technical domain. The course is designed for
graduate students, new employees, and industrial technology developers.
Keywords: Leadership, innovation, project management, technical development, tech development budget/finances
Andrew Zander is a successful technology developer and manager of engineering and scientific professionals. The
majority of his product development experiences were in the analytical instrument domain, for a variety of industries
ranging from semiconductor equipment; analytical, life sciences and biotechnology instrumentation, and drug discovery
tools businesses. He has managerial and technical experience in Department of Defense RDT&E from a 30-year career
with the U. S. Naval Reserve, 21 years of which were as a Scientific Liaison Officer for the Office of Naval Research.
Andy's most recent position was with Applied Scientific Concepts, Inc., managing a NASA-based contract to develop a 3D
LIDAR for Guidance and Navigation Control on a spacecraft scheduled to intercept asteroid RQ36 in 2017.
Over the course of his 44-year career as an Analytical Chemist and RDT&E Director, Andy performed, managed, led or
directed the development of instrumentation, subsystems and devices in a wide variety of technologies, including: X-ray
technologies and components; Atomic and Molecular spectroscopy, spectrometry and spectrophotometry; Gas and Liquid
chromatography; Mass Spectrometry; Hyphenated instruments; Field/Ruggedized instruments; Atomic Force Microscopy;
and 3D Flash LIDAR.
Andy has had published 29 peer-reviewed journal articles, 21 non-refereed publications (e.g., book chapters) and
authored multiple manuals and training documents for project management. He has 3 patents.
Andy retired from full-time employment in January 2013, though he continues to do technical consulting with the Gerson
Lehrman Group. He and his wife, Sandie, reside in the Los Angeles area.
Megan Cotugno (M.A. Program Evaluation, Stanford University) is an Associate Survey Director within the RAND
Corporation’s Survey Research Group. She has over a decade of project management experience on large-scale,
longitudinal research projects that have spanned a broad set of topics, including national defense, health, and education.
She leads proposal writing; budgeting; instrument design; recruitment, training, and supervision of data collection teams;
overall progress of project implementation; data delivery; and methodology reporting. Ms. Cotugno works across survey
modes, including web surveys, telephone surveys, fieldwork, cognitive interviewing, mail surveys, and, most commonly,
mixed-mode studies. Her work uses designs that enable quantitative, qualitative, and mixed-method analyses. She has
managed data collection activities from diverse respondent populations, including active military personnel, school-age
youth, and adults with a variety of chronic illnesses. She has co-authored several RAND reports, professional conference
presentations, and peer-reviewed articles, mostly on the topic of survey methodology.
ST-02 Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) Using Isotope Dilution (ID): Fundamentals and
Applications to Elemental and Elemental Species Analysis, Sunday, January 10, 8 am, Jörg Bettmer and Maria
Montes-Baryon, Universidad de Oviedo, Departamento de Química Física y Analítica, C/ Julián Clavería 8, E-33013
Oviedo, Spain, bettmerjorg@uniovi.es, montesmaria@uniovi.es
Isotope dilution mass spectrometry (IDMS) has been well-known for a long time as an accurate analytical method for trace
analyte determinations. Within this short course the basic principles of IDMS (part 1) using inductively coupled plasmamass spectrometry (ICP-MS) and its applications as an accurate quantification tool will be discussed for the analysis of
total elemental concentrations (part 2) and elemental species (part 3). The latter part is dedicated to the explanation of the
two different existing modes, in which ICP-IDMS can be applied to the quantitative speciation of elements. Namely,
species-specific and species-unspecific isotope dilution analyses are discussed in detail on representative examples of
important elemental species. This course will also include a critical discussion about the potential and limitations of ICPIDMS in elemental analysis and elemental speciation.
Keywords: Isotope dilution mass spectrometry, ICP-MS, trace element analysis, elemental speciation
ST-03 Extraction Chromatography for Enhanced Elemental and Isotopic Analysis by ICPMS, Saturday, January 9, 8
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am, Michael Ketterer, Department of Chemistry and Biochemistry, Metropolitan State University of Denver, Campus Box
52, PO Box 173362, Denver, CO 80217-3362, mkettere@msudenver.edu
Extraction chromatography, or solid-phase extraction, mimics liquid-liquid extraction, utilizing a polymer-immobilized
selective reagent to retain target analytes from aqueous solutions. Analytes are separated from complex aqueous
matrices, pre-concentrated, and eluted in purified form. The recovered small-volume analyte solution is suited for
elemental and/or isotopic analysis; using isotope dilution, recovery-independent results are achievable. Examples of
analytes include Pb, Sr, Hf, Nd, Th, Tc, U, Pu, and Am. This course will describe the principles of extraction
chromatography, the considerations in designing a separation, and the commercially available technologies. Biological,
earth/environmental, and nuclear applications will be discussed.
Keywords: Extraction chromatography, pre-concentration, matrix removal, recovery, isotopic analysis, ICPMS
Michael E. Ketterer received his undergraduate education at the University of Notre Dame (BS, Chemistry, 1980) and
earned a PhD in Analytical Chemistry in 1985 from the University of Colorado. His PhD research was in the area of
electroanalytical chemistry, but he now considers himself a “recovering electrochemist”. He was employed in industry for
two years, and then he worked from 1987-1993 at the USEPA’s National Enforcement Investigations Center. In 1988,
while employed at EPA-NEIC, he began working with quadrupole ICPMS. From 1993-1998 he was Assistant Professor of
Chemistry at John Carroll University, and in 1998 he moved to Northern Arizona University, where he was Professor of
Chemistry and Biochemistry until 2013 when he became Professor and Chair of chemistry at Metropolitan State University
of Denver. His current research interests are in isotopic measurements, and studies of naturally occurring and artificial
radionuclides in the environment.
ST-04 Environmental Forensics: ICPMS-Based Isotopic Methods, Saturday, January 9, 7 pm, Michael Ketterer, ,
Department of Chemistry and Biochemistry, Metropolitan State University of Denver, Campus Box 52, PO Box 173362,
Denver, CO 80217-3362, mkettere@msudenver.edu
Forensic investigations of environmental contamination involve elements of “who”, “when”, “from where” and “why”, as
opposed to other investigations focused upon “what” and “how much”. For elements such as Pb or U, isotope
measurements are powerful qualitative and quantitative tools for addressing these forensic questions. This course will
explain the construction of a question and hypothesis, the underlying basis for variance in isotope compositions and how
these can be used in forensic studies. Case studies from the literature, as well as the authors’ own work will be discussed,
demonstrating the power and efficacy of this approach.
Keywords: Forensics, ICP-MS, isotope dilution, source identification, case studies, apportionment
ST-04 Environmental Forensics: ICPMS-Based Isotopic Methods, Saturday, January 9, 7 pm, Michael Ketterer, ,
Department of Chemistry and Biochemistry, Metropolitan State University of Denver, Campus Box 52, PO Box 173362,
Denver, CO 80217-3362, mkettere@msudenver.edu
Forensic investigations of environmental contamination involve elements of “who”, “when”, “from where” and “why”, as
opposed to other investigations focused upon “what” and “how much”. For elements such as Pb or U, isotope
measurements are powerful qualitative and quantitative tools for addressing these forensic questions. This course will
explain the construction of a question and hypothesis, the underlying basis for variance in isotope compositions and how
these can be used in forensic studies. Case studies from the literature, as well as the author’s own work will be discussed,
demonstrating the power and efficacy of this approach.
Keywords: Forensics, ICP-MS, isotope dilution, source identification, case studies, apportionment
ST-05 Tracing Element Metabolism in Animals and Humans Using Stable Isotope Techniques, Monday, January
11, 7 pm, Thomas Walczyk, Department of Chemistry, National University of Singapore, Science Drive 4, Singapore
117543, walczyk@nus.edu.sg
Participants will be familiarized in this course with the basic principles and practicalities of tracing element uptake,
utilization and excretion from the body in living organisms. This includes a basic introduction to human physiology,
metabolism and bioavailability of the most relevant essential elements (iron, zinc, calcium, selenium), theoretical concepts
of element tracing in living organisms based on isotope dilution principles, standard methods and protocols to study
element metabolism in animals and humans, aspects to consider in the design of such studies, practicalities of sample
collection and preparation as well as mass spectrometric analysis and, finally, principles and algorithms for translation of
analytical data into physiological information. Participants with a background either in inorganic mass spectrometry or life
sciences with an interest to conduct stable isotope studies in animals or humans are encouraged to attend. Expertise in
isotope analysis and/or basic physiology is an advantage but not a prerequisite for attending the course
Keywords: Stable isotopes, element metabolism, biomedical research, human studies, animal studies, isotope dilution
mass spectrometry
Thomas Walczyk is a chemist by training who earned his PhD degree in isotope sciences/isotope ratio mass
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spectrometry. For more than 20 years he has been exploring the potential of stable isotope techniques in biomedical
research and contributed significantly to the shaping of the field and its recognition as a research domain in inorganic
mass spectrometry. After more than a decade at the Laboratory of Human Nutrition at ETH Zurich, he joined the National
University of Singapore as a faculty member in 2007, jointly appointed by the Department of Chemistry (Science) and the
Department of Biochemistry (Medicine).
ST-06 Contamination Control for Trace Element Analysis, Sunday, January 10, 1 pm, Brad McKelvey, Seastar
Chemicals Inc., 10005 McDonald Park Rd., Sidney, BC V8L 5Y2, Canada, bmckelvey@seastarchemicals.com
Current instrumentation has the ability to determine many elements down to the ppt and ppq level. However, many
analytical techniques for trace element determinations are limited by the blank. The focus of this course will be
contamination control and strategies to determine and eliminate contamination sources. This course will discuss
contamination sources from the environment, labware, reagents, sample handling and sample introduction systems.
Participants will be encouraged to discuss their contamination problems and experiences.
Keywords: Contamination control, trace element analysis, blanks
Brad McKelvey is Senior Research Scientist at Seastar Chemicals Inc. Seastar Chemicals is a global supplier of high
purity reagents for trace element analysis. Dr. McKelvey has over 20 years experience in ICP-MS analysis, sample
preparation, and contamination control for ultra-trace elemental analysis.
ST-07 Adjusting Your Laboratory for Trace Analyses, Sunday, January 10, 8 am, Ela Bakowska, Elba Elemental
Consulting, PO Box 1050, Corning, NY 14830, ela_bakowska@yahoo.com
The improvements of trace or ultra-trace capabilities are achieved by reducing and eliminating sources of elemental
contamination and by optimization of the laboratory layout. The contamination of a sample may occur during collection,
storage, preparation and analysis. Specific examples of appropriate reagents and lab supplies will be listed. Cost saving
alternatives for lab design and operation will be presented. Sample preparations considerations for different applications
(semiconductor, environmental, clinical) will be discussed. Sources of specific elemental contaminations and ways of
eliminating or minimizing them will be discussed. Experiences of purchasing a new ICP-MS will be shared with the
participants.
Keywords: Laboratory design, contamination sources, contamination prevention, supplies, ICP-MS, sample preparation
Ela Bakowska has over 25 years of experience in elemental testing of clinical, forensic, pharmaceutical, glass,
ceramics, environmental, semiconductor, nuclear, food and geological samples. She is an author of 21 publications and
over 100 abstracts and presentations at national and international conferences. Ela holds an M.S. in Physical Chemistry
from the Warsaw University (Poland) and Ph.D. in Analytical Chemistry from the University of Massachusetts, Amherst.
Dr. Bakowska is a Technical Director at Elba Elemental Consulting. Her responsibilities include providing expert
testimonies, reviews of articles and grant proposals, writing technical notes, SOPs, evaluating ICP-MS instrumentation and
modernization of trace metals laboratories. She provides consultation to clinical, and other customers, teaches workshops
and lectures. Her current and past employers include Corning Incorporated, NMS Labs, Agilent Technologies and HewlettPackard, Dow Chemical Company, University of Massachusetts, and ITME - Institute of Electronic Materials Technology
(Poland)
ST-08 Clean Microwave Digestions for Ultra-Trace Analysis, Monday, January 11, 7 pm, Joaquim A. Nóbrega,
Federal University of São Carlos, Department of Chemistry, São Carlos, SP, Brazil, djan@terra.com.br
This short course presents general aspects related to the microwave-assisted sample preparation and its application for
ultra-trace analysis using spectrochemical instrumental techniques, particularly ICP OES and ICP-MS. Trace analysis will
be discussed considering analytical blanks and contamination control. Effects caused by reagent and materials impurities,
laboratory environment, and analytical procedures will be stressed. Procedures for purifying acids and cleaning vessels
will be discussed. Benefits resulting from closed vessels digestion and special procedures, such as digestions using
diluted nitric acid solutions with emphasis on oxygen gas role on chemical oxidative reactions and single vessel
strategies, also will be discussed. Applications for different types of samples, for instance biological tissues, botanical
tissues, and foods, will be highlighted.
Keywords: HEPA filters, clean rooms, clean laboratories, microwave digestions, sample preparation, extraction, trace
element analysis, clean laboratory chemistry, applications
Joaquim A. Nóbrega received his Ph.D. from the State University of Campinas (1992) and completed his postdoctoral
training with Ramon Barnes (University of Massachusetts, Amherst, MA, 1996) and with Bradley Jones (Wake Forest
University, Winston-Salem, NC, 2003). He is Associate Professor in the Department of Chemistry at the University
Federal of São Carlos (São Carlos, São Paulo State, Brazil) and Visiting Professor in the Faculty of Pharmacy at the
University of Concepción (Concepción, Chile). His research interests are sample preparation for inorganic analysis,
atomic absorption spectrometry, atomic emission spectrometry, and inductively coupled plasma mass spectrometry. He
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co-authored a chapter in 2011 on “Microwave-Assisted Sample Preparation for Spectrochemistry” published in the online
Encyclopedia of Analytical Chemistry. He is a member of the Brazilian Society of Chemistry, Brazilian Society for the
Advancement of Science, American Chemical Society, the Society for Applied Spectroscopy, International Union of Pure
and Applied Chemistry, and the Royal Society of Chemistry.
ST-09 Microwave-Assisted Sample Preparation for Spectrochemistry, Sunday, January 10, 8 am, Joaquim A.
Nóbrega, Federal University of São Carlos, Department of Chemistry, São Carlos, SP, Brazil, djan@terra.com.br
This course presents both selected applications and the theory for sample preparation featuring microwave-assisted
digestion for elemental and ultra-trace elemental analysis. Specific sample preparation approaches for AAS, ICP-MS and
ICP OES including microwave power, reagent temperature, pressure, matrices, chemical compatibility, and practical
standard methods will be discussed. Basic features of microwave decomposition methods, equipment, vessel design, and
accessories will be covered. Methods for transfer of procedures between equipment are highlighted, and applied methods
such as the 3052 developed for EPA SW-846 for total microwave digestion of soils, sediments, ash, tissues, foods, and
combination of these samples are reviewed. Safety considerations in laboratory microwave sample preparation and
analysis are stressed. Special applications based on digestions in closed vessels will be discussed with special emphasis
on new United States Pharmacopeia <232> and <233> regulations.
Keywords: Microwave heating, acid digestion, organic and inorganic sample preparation, elemental analysis,
environmental analysis, microwave equipment, microwave theory, safety
ST-10 Plasma Diagnostics: Fundamentals, Measurements, and Applications, Saturday, January 9, 7 pm, Igor B.
Gornushkin, BAM, Federal Institute for Materials Research and Testing, Berlin, Germany, igor.gornushkin@bam.de
This course will provide an introduction to plasma diagnostic techniques. The major focus of the course will be on the
discussions of the practical procedures as well as the underlying physical principles for the measurements of plasma
fundamental characteristics (e.g., temperatures, thermodynamic properties, and electron number density). Particular
emphasis will be placed on inductively coupled plasma–atomic emission spectrometry, but other analytical plasmas will
also be used as examples when appropriate. Selected examples on how one can manipulate the operating conditions of
the plasma source, based on the results of plasma diagnostic measurements, to improve its performance used for
spectrochemical analysis will also be covered. Topics to be covered include thermal equilibrium, line profiles,
temperatures, electron densities, excitation processes, microreactions, pump and probe diagnostics, tomography,
temporal and spatial resolution. Basis of plasma computer modeling will be presented.
Keywords: Thermal equilibrium, plasma processes, electron number density, temperatures, emission line profiles, spatial
information, plasma modeling
ST-11 Uncertainty Budget Cookbook – Ready to Serve, Saturday, January 9, 1 pm, Thomas Prohaska, University of
Natural Resources and Life Sciences, Department of Chemistry, VIRIS Laboratory, Konrad, Lorenz Strasse 24, A-3430
Tulin, Austria, thomas.prohaska@boku.ac.at
Metrology in chemistry is defined as the science of measurements. Even though we take care about the best
measurement results, the validity of these results is determined by their uncertainties since any measurement is subject to
uncertainty. Thus, a proper understanding of uncertainty budgets and the sources of error is crucial for providing proper
uncertainty statements. This short course provides the basic understanding for building a proper uncertainty budget and
provides different approaches for doing so. Working on practical examples, the participants should be able to transfer the
knowledge to their own measurement results.
Keywords: Uncertainty budget, error propagation, metrology in chemistry, applications
Thomas Prohaska is an analytical chemist at the Austrian University of Natural Resources and Life Sciences where he is
involved in research and teaching. His major research focus lies on elemental and isotopic analysis by using mass
spectrometric techniques for applications in analytical ecogeochemistry. The main areas of research cover the fields of
food provenance and quality, environmental bio-monitoring, migration studies and forensic science. Born in 1968, he
studied Chemistry at the Vienna University of Technology. He received his PhD with summa cum laude in 1995 in the field
of surface analysis by scanning probe microscopy and became a scientific researcher at the BOKU Vienna to build up a
laboratory for elemental trace analysis. In 1996 he was visiting scientist at the Muroran Institute of Technology in Japan
and from 1998 to 2000 he was working as researcher at the European Commission joint research center IRMM in Geel,
Belgium. Afterwards he returned to Vienna with the focus on stable isotope research and became associate professor at
the Department of Chemistry in 2002. A research award from the Austrian Science Fund (START prize by the FWF and
the Austrian Ministry of Science) enabled the setup of a new isotope research laboratory (VIRIS laboratory) in 2006. In
2011 he was visiting scientist in Singapore and moved in the same year with the VIRIS laboratory to the new research
building in Tulln, Austria, where the laboratory has developed a strong focus on analytical ecogeochemistry. Dr. Prohaska
is author of more than 100 peer reviewed scientific publications. He is director of the Austrian Society for Chemistry and
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Physics, member of the certification advisory panel of the EC-JRC IRMM, Belgium, Geel, member of the IUPAC
subcommittee on Isotopic Abundance Measurements, member of the IUPAC subcommittee on Stable Isotope Reference
Material Assessment, titular member of the IUPAC commission on Isotopic Abundances and Atomic Weights, member of
the Austrian Academy of Science (directorial board of the ‘junge Kurie’), member of the working group on Techniques and
Standards for Destructive Analysis of the ESARDA (European Safeguards Research and Development Association), and
member of the EURACHEM WG for education and training and the Austrian representative for the European Commission
TrainMiC program.
ST-12 ETV-AAS, ICP-AES/ICP-OES, Quadrupole and Sector Field ICP-MS Method Development Problem Solving,
Saturday, January 9, 1 pm, R. Steven Pappas and Mark R. Fresquez, Centers for Disease Control and Prevention, 4770
Buford Hwy, MS F-44, Atlanta, GA 30341-3717, rpappas@cdc.gov
Optimization, interferences, and troubleshooting will be discussed for ICP-AES. Optimization, troubleshooting, and matrix
modification will be discussed for ETV-AAS. After discussion of sample preparation problem solving for atomic
spectrometry of liquid or digested samples, we will describe advantage of instrument capabilities to accomplish analytical
goals. Approaches to utilization of kinetic energy discrimination, reactive gases, and mass shift for quadrupole and “triple
quad” ICP-MS, the use of resolution, mass windows, mass offset, and similar techniques for magnetic sector ICP-MS, and
the use of desolvating introduction systems for increased sensitivity and decreased interferences will be discussed. If
communicated in advance, individual problems will be considered.
Keywords: Sample preparation, method development, problem solving, memory effect, digestion, desolvation,
environmental, biological, electrothermal vaporization
Steve Pappas earned his BS in Chemistry at Middle Tennessee State University in Murfreesboro, TN. He completed his
graduate training in biochemistry at Vanderbilt University, Nashville, TN, with emphasis analytical method development for
vitamin A metabolites in male reproductive tissue and for bacterial carbohydrates. After two faculty positions at Middle
Tennessee State University and Georgia State University, he joined the Centers for Disease Control and Prevention
(CDC) to develop ICP-MS methods for actinide analysis in urine. His duties expanded to include development and
improvement of methods for analysis of toxic metals in blood, urine, and hair, and training state health department
laboratorians in these methods. At present, he is involved in method development and analysis for toxic metals in tobacco
and smoke.
Mark Fresquez earned his B.S. in Chemistry at New Mexico State University in 1988, and subsequently his graduate
training in analytical chemistry at the same institution. Mark began his career in commercial environmental trace metal
analysis laboratories working with a wide variety of matrices and instrumentation for 13 years. Afterwards he was
employed at the Centers for Disease Control and Prevention (CDC) working with arsenic speciation in urine utilizing
HPLC-ICP-MS and mercury speciation in blood using HPLC-ICP-MS and GC-ICP-MS. Subsequently at CDC he was
responsible for development of methods for analysis of tobacco and smoke for toxic metals. He is responsible not only for
the development but also in the high throughput analysis of laboratory deliverables for the Tobacco Inorganics Group. He
has over 24 years of inorganic trace metals analysis experience with a wide range of instrumentation including ETV-AAS,
ICP-OES/AES, ICP-MS, as well as hyphenated techniques. He is responsible for publishing data and training other
analysts in a research and development, sample analysis laboratory with ISO 17025 accreditation.
ST-13 Sample Preparation Problem Solving for Atomic Mass Spectrometry, Sunday, January 10, 1 pm, R. Steven
Pappas and Naudia Gray, Centers for Disease Control and Prevention, 4770 Buford Hwy NE, MS F44, Bldg 110, Atlanta,
GA 30341-3717, rpappas@cdc.gov
Topics to be covered include discussion of preparation of liquid samples such as water, urine, and blood, biological solid
sample digestion, very brief coverage of solid inorganic and metal sample dissolution, chemistry related to analytes of
interest, including chelation and avoiding memory effects. Approaches to optimization and the use of desolvating
introduction systems for increased sensitivity and decreased interferences will be discussed. Limited discussion will touch
on special needs such as considerations necessary for organic solvents and use of electrothermal vaporization.
Keywords: Sample preparation, memory effects, chelation, digestion, desolvation, environmental and biological samples,
electrothermal vaporization
R. Steven Pappas earned his B.S. in Chemistry at Middle Tennessee State University in 1986. He completed his doctoral
training in Biochemistry at Vanderbilt University. After faculty positions at Middle Tennessee State University and Georgia
State University, he was employed at the Centers for Disease Control and Prevention (CDC) to develop methods for
analysis of toxic metals in urine and blood for emergency response state health department laboratory training. In the
second phase of his work at CDC, he became responsible for development of methods for analysis of tobacco and smoke
for toxic metals. He subsequently became the Tobacco Inorganics Group Team Lead. He oversees method development,
ISO 17025 accreditation, and analyses for toxic metals in tobacco and smoke. He is responsible for publishing and
interpreting data in terms of public health risks. In addition to application manuscripts, he has written the Annex behind
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World Health Organization Technical Report Series 967 on toxic metals in tobacco and smoke with emphasis on
inflammation and sensitization responses in animal and human studies, and a metallomics review on the same topic.
Naudia Martone Gray received her Bachelors and Masters degrees in Environmental Science at Duquesne University
under Dr. Skip Kingston in 2012. Her graduate project involved the use of species specific isotope dilution for speciation of
chromium with quadrupole ICP-MS. After completing her masters, she began to work in the Tobacco and Volatiles Branch
of CDC in the Tobacco lnorganics group under Dr. Steve Pappas. Her projects have included determination of cigarette
and little cigar physical properties, development and utilization of methods for analysis of toxic metals in tobacco and
tobacco smoke using microwave digestion, quadrupole ICP-MS, “Triple Quadrupole” ICP-MS, and combustion mercury
analyzer.
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ST-14 Validation Assessment, An Interactive Session, Sunday, January 10, 1 pm, Rob Ritsema, National Institute for
Public Health and the Environment (RIVM), PO Box 1, 3720 BA Bilthoven, The Netherlands, rob.ritsema@rivm.nl; Petra
Krystek, Institute for Environmental Studies (IVM), VU University Amsterdam, De Boelelaan 1087, NL-1081 HV
Amsterdam, The Netherlands, petra.krystek@ivm.vu.nl
This course will give an overview about the validation of analytical methods and procedures, which is an integral part of
any good analytical practice. Method validation is the process used to confirm that the analytical procedure employed for
a specific test is suitable for its intended use. Results from method validation can be used to judge the quality, reliability
and consistency of analytical results. For making this information as practice relevant as possible, several examples like a
procedure for the determination of selected elements in water by ICPMS will be discussed in detail. Special attention will
be given to sampling and storage. Other examples from the inorganic analytical field of environmental, food and biological
matrices will be covered too. Besides the methodological aspects and the obtained analytical results, the ten most
relevant performance characteristics (limit of detection, recovery, repeatability, reproducibility, measuring range, trueness,
lack of fit, expanded uncertainty of measurement, robustness and selectivity) are defined, calculated and discussed; also
in relation if the analytical method should fulfil to section 5.4.5 of the accreditation standard ISO 17025. This course will be
held as an interactive session.
Keywords: Quality assurance, validation assessment, performance characteristics, ICPMS
Rob Ritsema obtained his PhD in 1997 at the Université de Pau et des Pays de l’Adour, Pau, France. For 15 years he
has worked at the accredited laboratory of the National Institute of Public Health and the Environment (RIVM) in the field
of ICP-MS, focusing on environmental, food and body fluid analysis. For a few years he has been working at the
intermediate between the ministry of Public Health/Ministry of Environment and the RIVM. Since 1998 he is a freelance
assessor the Dutch Accreditation Council (RvA) performing approximately 20 audits on a yearly base at laboratories in the
Netherlands and Belgium that are accredited according to ISO 17025. He is board member of the working group Atomic
Spectrometry of the Royal Netherlands Chemical Society (KNCV) and he is the National Representative (president) of
EURACHEM which is a European network of organisations having the objective of establishing a system for the
international traceability of chemical measurements and the promotion of good quality practices.
ST-15 Atomic Spectroscopy for Forensic Applications, Sunday, January 10, 8 am, Suresh Kumar Aggarwal, 1006,
Sunflower, Neelkanth Gardens, Govandi-East, Mumbai 400088, India, skaggr2002@gmail.com
Atomic spectroscopy techniques like inductively coupled plasma mass spectrometry (ICPMS), laser induced breakdown
spectroscopy (LIBS), and total reflection X-ray fluorescence (TXRF) provide useful analytical data on elemental profile
and isotopic composition of different elements. These data are highly useful for forensic studies in various fields including
food authentication, printing ink, paper industry, pollution studies, and nuclear technology. This course will give an
introduction to the present status of the different analytical techniques used in forensics for elemental determinations as
well as present examples of the data available for applications in various fields. The course will introduce chemometrics
for forensic studies. It is intended for novices and practitioners of mass spectrometry as well as for those interested in
forensic sciences.
Keywords: ICPMS, LIBS, TXRF, elements, isotope ratio, concentration profile, nuclear, food, paper, pollution
apportionment
Suresh K. Aggarwal is a Senior Professor of Chemistry at Homi Bhabha National Institute (HBNI), Mumbai; Professor of
Analytical Chemistry at Mumbai University; President of Indian Society for Mass Spectrometry (ISMAS) and President of
Indian Society for ElectroAnalytical Chemistry (ISEAC). He has more than four decades of experience in atomic mass
spectrometry for applications in nuclear, geochronological, biological and food sciences. He has published more than 200
papers in international journals, guided 17 Ph.D. students, and has served as an IAEA. He retired recently from Bhabha
Atomic Research Centre, Department of Atomic Energy, Mumbai after 41.5 years as Associate Director of Radiochemistry
and Isotope Group.
ST-16 Field-Flow Fractionation in Hyphenated Techniques: Measurement Quality Control and Applications in
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Healthcare and Environmental Safety, Monday, January 11, 7 pm, Heidi Goenaga-Infante, Dorota Bartczak and
Panayot Petrov, LGC Limited, Queens Road, Teddington, Middlesex TW11 OLY, UK, heidi.goenagainfante@lgcgroup.com
Field- flow fractionation (FFF) in combination with elemental and sizing detectors has emerged as a highly promising
approach for size-based elemental speciation in complex environmental samples and consumer products such as food
1,2. Given the complexity of nano-objects and of the matrix in most real samples, the use of a single measurement
technique has often resulted in their ambiguous detection and characterization. The use of a multi- method approach
based on the combination of a powerful fractionation technique (e.g., FFF) with appropriate detection systems (e.g., ICPMS, MALS, TEM, NTA, etc.) could prove invaluable for providing comprehensive and accurate information on the
properties of target species/nano-objects. This may be useful for their unambiguous detection and characterization in
complex environments.
This short course will discuss the potential of combining asymmetric flow- field-flow fractionation with detection systems
such as ICP-MS, MALS, NTA and TEM for the determination of size-based elemental fractionation and number-based
concentration of metal(loid)-containing nanomaterials in complex samples. The benefits of multi-method approaches for
the determination of size, size distribution, number based concentration and size-based elemental composition in real
samples with a variety of nano-objects/species will be demonstrated through applications to (i) the characterization of
nanomaterials added to food, (ii) the characterization of silica nanoparticles in biological cell media relevant to
nanotoxicology, (iii) the fractionation and characterization of plasma metalloproteins, and (iv) the investigation of the
partitioning of EU Water Frame Directive (WFD) contaminants such as PBDEs into environmental water compartments.
Special attention will be paid to the systematic development of sample preparation procedures as a trade-off between
extraction efficiency and preservation of the measurand properties, also to FFF method optimization with regards to
separation selectivity and nanoparticle recovery. Quality control aspects such as remaining challenges in mass balance
calculations and the need of quality control or reference materials as well as of laboratory intercomparisons for method
validation will also be discussed.
[1] F. Von der Kammer, S. Legros, E.H. Larsen, K. Loeschner, T. Hofmann, Trends Anal. Chem. 30, 425-436 (2011).
[2] V. Nischwitz, H. Goenaga-Infante, J. Anal. At. Spectrom. 27, 1084-1092 (2012).
Keywords: Quality control, compound identification, speciation analysis, FFF, healthcare applications
Technical Seminar
TS-01 Measurement of Size, Shape and Density of Nanoparticles Using Centrifugal Field-Flow Fractionation and a
Multi Detection System, Saturday, January 9, 1 pm, Soheyl Tadjiki, Postnova Analytics, Inc., Salt Lake City, UT84102,
soheyl.tadjiki@postnova.com
Field-Flow Fractionation (FFF) is a family of high resolution techniques that are capable of rapid and high efficiency
separation of macromolecules, colloids and particles. Centrifugal FFF (CFFF) is an FFF sub-technique that utilizes
centrifugal force to separate nanoparticles and particles with the highest size selectivity. The separation in CFFF is based
on particle effective mass with a mass resolution in the order of 10-18 g. Particle size distribution can be obtained from
CFFF data if the particle density is known. CFFF can also be interfaced with on-line multi angle light scattering (MALS)
and dynamic light scattering (DLS) detectors to measure root-mean square radius and hydrodynamic radius of particles.
These radii can be combined with the CFFF size measurement data to predict particle shape and density.
In this technical seminar, three different case studies will be discussed in detail. A CFFF methodology will be outlined to
separate a mixture of silver nanoparticles in the size range of 20-100 nm. A selection of run conditions will be discussed to
optimize resolution and recovery of the nanoparticles. CFFF-MALS-DLS will be used to predict the shape and density of
silica nanospheres and gold nanorods. A combination of CFFF and UV-Vis diode array detection will be utilized to
characterize a mixture of silver ions and silver nanoparticles. Advantages and limitations of CFFF to qualify and quantify
dissolved species will be discussed.
At the seminar a running CFFF instrument with MALS, DLS and UV-Vis detectors will be available to demonstrate the
above mentioned case studies. The attendees will have the opportunity to participate in the practical aspects of the CFFF
analysis and data processing.
Complementary sandwiches and beverages will be provided prior to the seminar.
Keywords: Field-Flow Fractionation, Centrifugal FFF, MALS, DLS, Nanoparticles, Size, Shape, density, Silver, Gold,
Silica, dissolved ions
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