Prioritization of Veterinary Medicines in China’s Environment
Na Wang1, 2, Xinyan Guo3, Zhengjun Shan2, Zanchang Wang2, Yi Jin2,
Shixiang Gao1, *
1.State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210093, China;
2.Nanjing Institute of Environmental Science, Ministry of Environmental Protection of China, Nanjing 210042, China.
3.College of life science and technology, China Pharmaceutical University, Nanjing 210009, China
First: Email: wangna@nies.org
Second: Email: guoxinxinyan@126.com
Third: Email: sszjnies@163.com
Forth: Email: 731696768@qq.com
Fifth: Email: Jinyi@nies.org
*Corresponding: E-mail: ecsxg@nju.edu.cn
Table S1 The data of assessment of the potential to reach the environment of veterinary medicines
Usage
No.
Ingredient
Types of drugs
Annual sales volume
(ton)
1
1-Bromo-3-Chloro-5,5-Dimethyl
Hydantoin
The possibility of entering the environment
Class
Target group
Administration route
Excretion rate(%)
Class
Aquaculture
2500
H
aq, h
T
NA
H
Reference
Chinese Veterinary Medicine 114 Net
（online）
Chinese Veterinary Medicine 114 Net
2
Albendazole
Endoparasiticides（Anthelmintics）
NA
U
h,c
O
Cattle: 50
M
3
Aminopyrine
NSAIDs
1400
H
h, c
O
NA
H
Boxall et al.,2002
4
Amoxicillin
Antibiotics
4100
H
aq, h
O, T
Human: 80-90
H
Kim et al., 2008
5
Ampicillin
Antibiotics
NA
U
aq, h
O,T
Human: 30-60
H
Kim et al., 2008
6
Amprolium
Endoparasiticides（antiprotozoals ）
NA
U
h
O
-
H
7
Avermectin
Endoparasiticides（Coccidiostat）
412*
H
aq, h
O
NA
H
8
Bacitracin
Antibiotics
NA
U
h
T
Chickens, pig: 98
H
9
Benzalkonium Bromide
Aquaculture
3000
H
aq, h
T
NA
H
10
Chloroquanidi Hydrochloride
Endoparasiticides（antiprotozoals ）
NA
U
h
O
-
H
Boxall et al.,2002
11
Chlortetracycline
Antibiotics
71900
H
aq, h
O
Human: > 70
H
Kim et al., 2008
12
Ciprofloxacin
Antibiotics
NA
U
h, c
O
Human: 83.7
H
Kim et al., 2008
13
Clopidol
Endoparasiticides（antiprotozoals ）
NA
U
h
O
Rabbit:
47
M
14
Colistin Sulfate
Antibiotics
4289.9*
H
aq, h, c
O, T
Human: 63
H
15
Cypermethrin
Aquaculture
3000
H
aq
O
Dog:
26 to 51
H
（online）
Chinese Veterinary Medicine 114 Net
（online）
Chinese Veterinary Medicine 114 Net
（online）
Boxall et al.,2002
Chinese Veterinary Medicine 114 Net
（online）
Chinese Veterinary Medicine 114 Net
（online）
Chinese Veterinary Medicine 114 Net
（online）
IPCS Inchem（online）
16
Cyromazine
Endoparasiticides（Coccidiostat）
436*
H
h
O, T
Rats:
80
17
Dexamethasone
NSAIDs
1927
H
h, c
O
Male Wistar albino rats:
18
Diaveridine
Antibiotics
NA
U
aq, h
O
19
Diclazuril
Endoparasiticides（Coccidiostat）
3300
H
h
O
20
Diethylcarbamazine
Endoparasiticides（antifilarials）
NA
U
h,c
O
Animal：10-25
L
21
Dimetridazole
Endoparasiticides（antiprotozoals ）
NA
U
h
O
-
H
22
Diminazene Aceturate
Endoparasiticides（antiprotozoals ）
NA
U
h
O
Cattle：54.1
M
23
Dinitolmide
Endoparasiticides（antiprotozoals ）
NA
U
h
O
Animal:0
L
24
Doxycycline
Antibiotics
1089.42*
H
aq, h, c
O
Human: 30-40
H
Kim et al., 2008
25
Enramycin
Antibiotics
3200
H
aq, h
O
NA
H
Kim et al., 2008
26
Enrofloxacin
Antibiotics
600
H
aq, h,c
O,T
Rat: 17
H
Kim et al., 2008
27
Erythromycin
Antibiotics
NA
U
h, aq, c
O, T
Human: 5
H
Kim et al., 2008
28
Ethopabate
Endoparasiticides（antiprotozoals ）
NA
U
h
O
Chicken: 98
H
29
Fenbendazole
Endoparasiticides（Anthelmintics）
NA
U
h,c
O
Sheep, cattle: 44-50
M
30
Fenvalerate
Aquaculture
NA
U
aq, h
T
NA
H
31
Florfenicol
Antibiotics
1483.41*
H
h
O
32
Gentamicin
Antibiotics
NA
U
aq, h, c
O,T
44
NA
Rats,rabbits,chickens,turkeys,monkeys:
83.3-93.1
Pig, cattle, chickens:
Human: 90
33.6-58.8
H
IPCS Inchem（online）
M
IPCS Inchem（online）
H
Kim et al., 2008
H
Boxall et al.,2002
Chinese Veterinary Medicine 114 Net
（online）
Chinese Veterinary Medicine 114 Net
（online）
Chinese Veterinary Medicine 114 Net
（online）
Chinese Veterinary Medicine 114 Net
（online）
Chinese Veterinary Medicine 114 Net
（online）
Chinese Veterinary Medicine 114 Net
（online）
Chinese Veterinary Medicine 114 Net
（online）
M
Kim et al., 2008
H
Kim et al., 2008
33
Ivermectin
Endoparasiticides（Coccidiostat）
6800
H
aq, h
O
Cattle, sheep, Rat: 24.6-76.4
M
Boxall et al.,2002
34
Kanamycin Sulfate
Antibiotics
NA
U
h, c
O, T
Human: 80-90
H
Kim et al., 2008
35
Kitasamycin
Antibiotics
NA
U
h
O
NA
H
IPCS Inchem（online）
36
Levamisole
Endoparasiticides（Anthelmintics）
NA
U
h, c
O
Human: 4
L
37
Lincomycin Hydrochloride
Antibiotics
NA
U
aq, h, c
O，T
Human, dog, rat: 17.6-36.4
H
38
Maduramicin Ammonoium
Endoparasiticides（Coccidiostat）
7500
H
h
O
Turkey11.7-19.7
H
39
Mequindox
Antibiotics
1660.56*
H
h
O
Pig: 75
M
40
Metronidazole
Endoparasiticides（antiprotozoals ）
NA
U
h
O
Human: 91
H
41
Monensin
Endoparasiticides（Coccidiostat）
4400
H
h
O
Rats: 70-91
H
42
Neomycin Sulphate
Antibiotics
NA
U
h, aq, c
O, T
Human, cattle: 63-72
H
43
Nicarbazin
Endoparasiticides（Coccidiostat）
NA
U
h
O
NA
H
44
Niclosamide
Endoparasiticides（Anthelmintics）
NA
U
h,c
O
Pigs:78
M
45
Nitroclofene
Endoparasiticides（Anthelmintics）
NA
U
h
O
Cattle，sheep：0
L
46
Norfloxacin
Antibiotics
NA
U
aq, h, c
O, T
Human: 24
H
Kim et al., 2008
47
Novaldin
NSAIDs
7174
H
h, c
O
NA
H
IPCS Inchem（online）
48
Olaquindox
Antibiotics
NA
U
h
O
Pigs: 90
H
IPCS Inchem（online）
49
Oxfendazole
Endoparasiticides（Anthelmintics）
NA
U
h,c
O
Sheep：65
M
Chinese Veterinary Medicine 114 Net
（online）
Kim et al., 2008
Chinese Veterinary Medicine 114 Net
（online）
Chen L Y, 2002
Chinese Veterinary Medicine 114 Net
（online）
Chinese Veterinary Medicine 114 Net
（online）
Kim et al., 2008
Chinese Veterinary Medicine 114 Net
（online）
Chinese Veterinary Medicine 114 Net
（online）
Chinese Veterinary Medicine 114 Net
（online）
Chinese Veterinary Medicine 114 Net
（online）
50
Oxytetracycline
Antibiotics
NA
U
aq, h
O
Human: > 80
H
51
Paracetamol
NSAIDs
5736
H
h
O
Human: 3
L
52
Pefloxacin
Antibiotics
NA
U
h
O
Human:9-16
L
53
Penicillin G Potassium
Antibiotics
1800
H
aq, h, c
O
Human: 60
H
54
Phoxim
Aquaculture
2000
H
aq
O
Mouse: 73-82
H
55
Piperazine
Endoparasiticides（Anthelmintics）
NA
U
h,c
O
Pigs:71.6, chicken:42
M
56
Praziquantel
Endoparasiticides（Anthelmintics）
NA
U
h,c
O
Animal，human：0
L
57
Pyrantel Pamoate
Endoparasiticides（Anthelmintics）
NA
U
h,c
O
Pigs:0
L
58
Quinapyramine
Endoparasiticides（antiprotozoals ）
NA
U
h
O
-
H
59
Rafoxanide
Endoparasiticides（Anthelmintics）
NA
U
h
O
-
H
60
Salinomycin
Endoparasiticides（Coccidiostat）
14500
H
h
O
Chickens: 94.6
H
61
Spectinomycin
Antibiotics
NA
U
h
O
Human: 80-100
H
Kim et al., 2008
Chinese Veterinary Medicine 114 Net
（online）
Chinese Veterinary Medicine 114 Net
（online）
Chinese Veterinary Medicine 114 Net
（online）
IPCS Inchem（online）
Chinese Veterinary Medicine 114 Net
（online）
Chinese Veterinary Medicine 114 Net
（online）
Chinese Veterinary Medicine 114 Net
（online）
Chinese Veterinary Medicine 114 Net
（online）
Chinese Veterinary Medicine 114 Net
（online）
Chinese Veterinary Medicine 114 Net
（online）
Kim et al., 2008
Chinese Veterinary Medicine 114 Net
62
Streptomycin Sulphate
Antibiotics
NA
U
aq, h
O
Dogs:60-80
M
63
Sulfaclozine
Endoparasiticides（Coccidiostat）
2200
H
aq, h
O
NA
H
64
Sulfadiazine
Antibiotics
NA
U
aq, h
O
Animals: 75
H
65
Sulfadimidine
Antibiotics
NA
U
aq, h
O, T
Cattle: 18
H
Kim et al., 2008
66
Sulfamethoxazole
Antibiotics
NA
U
aq, h, c
O
Human: 30
H
Kim et al., 2008
67
Sulfamethoxydiazine
Antibiotics
NA
U
aq, h
O
Animals: 75
H
IPCS Inchem（online）
68
Sulfamonomethoxine
Antibiotics
NA
U
aq, h
O
Animals: 75
H
69
Sulfaquinoxaline
Antibiotics
1700
H
h
O
NA
H
70
Sulfathiazole
Antibiotics
NA
U
aq, h
O, T
71
Tetracycline
Antibiotics
NA
U
aq, h
72
Tilmicosin
Antibiotics
NA
U
73
Toltrazuril
Endoparasiticides（Coccidiostat）
NA
74
Trichlorfon
Endoparasiticides（Coccidiostat）
75
Trichloroisocyanuric Acid
76
77
Chinese Veterinary Medicine 114 Net
（online）
Chinese Veterinary Medicine 114 Net
（online）
Chinese Veterinary Medicine 114 Net
（online）
Chinese Veterinary Medicine 114 Net
（online）
67
H
Kim et al., 2008
O
Human: > 80
H
Kim et al., 2008
h
O
Cattle: 90.67
H
Kim et al., 2008
U
h
O
Porket, chickens, rat: 0-83,7
H
Boxall et al.,2002
NA
U
aq, h
O
NA
H
Aquaculture
NA
U
aq, h
T
NA
H
TOXNET（online）
Trimethoprim
Antibiotics
NA
U
aq, h, c
O, T
Human, pig, fowl： 10.1
H
IPCS Inchem（online）
Tylosin
Antibiotics
NA
U
h, c
O, T
Fowl: 10
H
Kim et al., 2008
Note: * denotes the sale amounts of parent veterinary medicines in 2010
NA denotes no obtained data.
Animals:
（online）
Chinese Veterinary Medicine 114 Net
（online）
“h” denotes herd; “aq” denotes aquaculture; “c”denotes companion/individual
“O” denotes Others; “T” denotes topical
Table S2-1 Determination of hazard classification based on ecological toxicity of the veterinary medicines
Aquatic toxicity （mg/L）
Terrestrial toxicity （mg/Kg or mg/L）
No
Ingredient
Types of drugs
1
1-bromo-3-chloro-5,5-dimethyl hydantoin
Aquaculture
2
Albendazole
3
Aminopyrine
NSAIDs
-
4
Amoxicillin
Antibiotics
Pseudomonas aeruginos
EC50
0.0037
Kim et al.,2008
5
Ampicillin
Antibiotics
Vibrio fischeri
24h EC50
163
Kim et al.,2008
6
amprolium
-
-
-
-
-
-
7
Avermectin
Endoparasiticides（Coccidiostat）
Daphnia magna
NOCE
0.0125
Liu et al., 2008
Cucumber
48 h inhibition rate
8
Bacitracin
Antibiotics
Artemia salina
LC100
6.3
Kim et al.,2008
9
Benzalkonium bromide
Aquaculture
-
-
-
10
Chloroquanidi Hydrochloride
-
-
-
-
11
Chlortetracycline
Antibiotics
Pseudomonas aeruginosa
7d EC50
0.05
Kim et al.,2008
-
-
-
-
H
12
Ciprofloxacin
Antibiotics
Microcystis aeruginosa
EC50
0.005
Kim et al.,2008
-
-
-
-
H
13
Clopidol
-
-
-
-
-
-
14
Colistin sulfate
Antibiotics
-
-
-
-
-
-
15
Cypermethrin
Aquaculture
Daphnia magna
96h EC50
0.61 ×10-6
Xiong et al., 2002
-
-
-
-
H
16
Cyromazine
Endoparasiticides（Coccidiostat）
Gambusia affinis
72 h LC50
>100
Kim et al.,2008
Microbes
MIC
125
Zhang et al., 2002
L
17
Dexamethasone(DXM)
NSAIDs
-
-
-
-
-
-
-
-
U
18
Diaveridine
Antibiotics
-
-
-
-
-
-
-
-
U
19
Diclazuril
Endoparasiticides（Coccidiostat）
-
-
-
-
-
-
-
-
U
20
Dimetridazole
Gyrodactylus salaris
25% mortality over 1 hr
200
Boxall，2002
-
-
-
-
L
21
Diminazene aceturate
-
-
-
-
-
-
-
-
U
22
Doxycycline
Antibiotics
-
-
-
-
-
-
-
-
U
23
Enramycin
Antibiotics
-
-
-
-
-
-
-
-
U
Endoparasiticides
（Anthelmintics）
Endoparasiticides
（antiprotozoals ）
Endoparasiticides
（antiprotozoals ）
Endoparasiticides
（antiprotozoals ）
Endoparasiticides
（antiprotozoals ）
Endoparasiticides
（antiprotozoals ）
Assessment endpoints
Level
References
Photobacterium phosphoreum
1h EC50
0.62
Jiang et al., 2009
-
-
-
Zebrafish embryos
NOECs
0.02
Carlsson et al.,2013
-
-
-
-
H
-
-
-
U
-
-
-
-
H
-
-
-
-
M
-
-
U
125
Zhang et al., 2002
H
-
-
-
Target creature
Assessment endpoints
-
Level
References
Cla
Target creature
-
H
-
-
-
-
M
-
-
-
-
U
-
-
-
-
-
U
-
U
-
U
24
Enrofloxacin
Antibiotics
Daphnia magna
chronic NOEL
9.8
Kim et al.,2008
-
-
-
-
M
25
Erythromycin
Antibiotics
Selenastrum capricornutum
3d EC50
0.02
Kim et al.,2008
-
-
-
-
H
26
Ethopabate
-
-
-
-
27
Fenbendazole
Daphnia magna
48h EC50
0.012
Kim et al.,2008
-
-
28
Fenvalerate
Aquaculture
Zebrafish
96h LC50
0.9×10-4
lv et.al., 2011
-
-
29
Florfenicol
Antibiotics
Tetraselmis chuii
96h LC50
6.06
Ferreira et al.,2007
30
Gentamicin
Antibiotics
-
-
-
-
31
Ivermectin
Endoparasiticides（Coccidiostat）
Daphnia magna
48 h EC50
0.0025
Kim et al.,2008
32
Kanamycin Sulfate
Antibiotics
-
-
-
-
33
Kitasamycin
Antibiotics
-
-
-
-
5
Endoparasiticides
（antiprotozoals ）
Endoparasiticides
（Anthelmintics）
-
-
Microbes
Mycoplana bullata
ATCC
-
-
U
-
-
H
-
H
MIC or NOEC
0.4
Kim et al.,2008
H
MIC
1×10-3
Dijck et al., 1976
H
-
-
-
MIC
0.01
-
-
-
-
U
Kim et al.,2008
-
-
-
-
M
-
U
Mycoplana bullata
ATCC
-
H
Dijck et al., 1976
H
Physiology
34
Lincomycin Hydrochloride
Antibiotics
Daphnia magna
effect(phototactic behaviour
decreased)
35
Maduramicin ammonoium
Endoparasiticides（Coccidiostat）
-
-
-
-
-
-
-
36
Mequindox
Antibiotics
-
-
-
-
E.coli
MIC
0.5
Huang et al.,2008
H
37
Metronidazole
Pseudokirchneriella subcapitata
EC50 72h
40.4 mg/L
TOXNET （online）
-
-
-
-
M
38
Monensin
Endoparasiticides（Coccidiostat）
-
-
-
-
Plants
MIC or NOEC
0.15
Kim et al.,2008
H
39
Neomycin sulphate
Antibiotics
Daphnia magna
48h EC50
34.1
Kim et al.,2008
-
-
-
-
M
40
Nicarbazin
Endoparasiticides（Coccidiostat）
-
-
-
-
-
-
-
41
niclosamide
Carp
48 h LC50
0.235
42
Norfloxacin
Antibiotics
Vibrio fischeri
24h EC50
0.022
Kim et al.,2008
-
-
-
43
Novaldin
NSAIDs
-
-
-
-
-
-
-
44
Olaquindox
Antibiotics
M. aeruginosa
EC50
5.1
Halling al., 2000
E.coli
MIC
0.4382
Huang et al.,2008
H
45
Oxfendazole
zebrafish embryos
NOEC 24h
4.6
Gunnar et al., 2013
-
-
-
-
M
Endoparasiticides
（antiprotozoals ）
Endoparasiticides
（Anthelmintics）
Endoparasiticides
（Anthelmintics）
TOXNET
(online)
-
-
-
-
U
-
H
-
H
-
U
40 min EC50 Half
46
Oxytetracycline
Antibiotics
Penaeus Vanmamei
48h NOEC intoxication
0.055
Kim et al.,2008
Vibrio Fischeri
inhibitory
0.09
Wang et al.,2011
H
concentration
47
Penicillin G Potassium
Antibiotics
M. aeruginosa
7d EC50
0.006
Halling et al., 2000
48
Phoxim
Aquaculture
-
-
-
-
49
Piperazine
Daphnia magna
21d NOEC
12.5
50
Quinapyramine
-
-
-
51
Rafoxanide
-
-
52
Salinomycin
Endoparasiticides（Coccidiostat）
-
53
Spectinomycin
Antibiotics
54
Streptomycin sulphate
55
-
-
-
-
H
Silkworm
LC50
0.7037
Zhu et al.,2000
H
-
-
-
-
M
-
-
-
-
-
U
-
-
-
-
-
-
U
-
-
-
-
-
-
-
U
-
-
-
-
-
-
-
-
U
Antibiotics
Microcystis aeruginosa
7d EC50
0.007
Kim et al.,2008
-
-
-
-
H
Sulfaclozine
Endoparasiticides（Coccidiostat）
-
-
-
-
-
-
-
-
U
56
Sulfadiazine
Antibiotics
Selenasrum capricornotum
EC50
0.135
Holten et al.,1999
-
-
-
-
H
57
Sulfadimidine
Antibiotics
Pseudokirchneriella subcapitata
72h NOEC
0.001-0.103
Kim et al.,2008
-
-
-
-
H
58
Sulfamethoxazole
Antibiotics
Synechococcus leopolensis
96h EC50
0.0268
Kim et al.,2008
59
Sulfamethoxydiazine
Antibiotics
-
-
-
-
-
60
Sulfamonomethoxine
Antibiotics
Selenasrum capricornotum
72h NOEC
0.529
Holten et al.,1999
-
61
Sulfaquinoxaline
Antibiotics
-
-
-
-
62
Sulfathiazole
Antibiotics
Daphnia magna
48h EC50
80
Kim et al.,2008
63
Tetracycline
Antibiotics
Daphnia magna
EC10 48h NOEC
340
Wollenberger et al.,2000
Vibrio fischeri
24h EC50
0.0251
Kim et al.,2008
H
64
Tilmicosin
Antibiotics
-
-
-
-
-
-
-
-
U
65
Toltrazuril
Endoparasiticides（Coccidiostat）
-
-
-
-
-
-
-
-
U
66
Trichlorfon
Endoparasiticides（Coccidiostat）
carp
LC50
1.5
Fang et al., 2003
Earthworm
LC50
4332
Bai et al.,2011
H
67
Trichloroisocyanuric acid
Aquaculture
-
-
-
-
68
Trimethoprim
Antibiotics
Rhodomonas salinay
EC50
16
Kim et al.,2008
Endoparasiticides
（Anthelmintics）
Endoparasiticides
（antiprotozoals ）
Endoparasiticides
（Anthelmintics）
European
Union
Risk
Assessment Report, 2005
-
-
-
H
-
-
U
-
-
-
H
-
-
-
-
U
-
-
-
-
M
Cucumber
-
seeding height EC10
0.7
Liu et al., 2008
U
H
Cythophaga
69
Tylosin
Antibiotics
microcystis aeruginosa
7d EC50
0.0034
Kim et al.,2008
johnsonae 425
MIC
0.01
Dijck et al., 1976
DSM
No
Ingredient
ADI
Score
mg/kg bw
Table S2-2 Determination of hazard classification based on human health effect of the veterinary medicine
Toxicity endpoints
Half life
Metabolic
activity
Score
Class
H
1
1-bromo-3-chloro-5,5-dimethyl
hydantoin
Carcinogenicity
Mutagenicity
Reproductive
toxicity
Neurotoxicity
Immunotoxicity
Endocrine
Microbiological
General
toxicity
effects
toxicity
-
4
0
2
2
0
0
0
0
0
0
0
8
L
2
Amoxicillin
0.0007
16
0
2
0
3
3
0
0
3
0
0
27
H
3
Albendazole
0.05
8
4
5
5
0
0
0
0
3
0
2
27
H
4
Aminopyrine
-
4
0
0
0
0
3
0
0
3
0
2
12
L
5
Ampicillin
-
4
4
0
2
0
3
0
0
3
0
0
16
L
6
amprolium
0.1
4
0
0
0
0
0
0
0
0
0
0
4
L
7
Avermectin
0.25
4
0
0
5
0
0
3
0
0
0
0
12
L
8
Bacitracin
0.1
8
2
2
2
0
0
0
0
3
0
0
17
L
9
Benzalkonium bromide
-
4
2
2
2
0
0
0
0
0
0
0
10
L
10
Chloroquanidi Hydrochloride
-
4
0
0
0
0
0
0
0
0
0
0
4
L
11
Chlortetracycline
0.003
12
0
0
0
0
0
0
3
3
0
0
18
L
12
Ciprofloxacin
0.0006
16
2
5
2
0
0
0
0
3
0
0
28
H
13
Colistin sulfate
0.2
4
2
0
2
3
0
0
0
0
0
0
11
L
14
Cypermethrin
0-0.02
8
4
0
2
3
0
3
0
3
0
0
23
M
15
Cyromazine
0.02
8
0
0
2
0
0
3
0
3
0
2
18
L
16
Dexamethasone
0-0.015×10-6
20
0
0
5
0
0
0
0
0
0
0
25
H
17
Diaveridine
-
4
2
0
0
0
0
0
0
0
0
0
6
L
18
Diclazuril
0.03
8
0
0
5
0
0
0
0
3
0
0
16
L
19
Diethylcarbamazine
-
4
5
5
5
3
3
0
0
3
0
0
28
H
20
Dimetridazole
0.002
8
0
5
0
0
0
0
0
0
0
0
13
L
21
Diminazene aceturate
0.1
4
0
0
5
3
0
0
0
3
0
0
15
L
22
Dinitolmide
-
4
5
0
0
0
0
0
0
0
0
0
9
L
23
Doxycycline
0.005
12
2
2
5
0
0
0
0
0
0
0
21
M
24
Enramycin
0.075
8
2
0
0
0
0
0
0
0
0
0
10
L
25
Enrofloxacin
0.0006
16
2
5
5
0
0
0
0
3
0
2
33
H
26
Erythromycin
0.0007
16
2
0
2
0
0
0
0
3
0
0
23
M
27
Ethopabate
-
4
0
0
0
0
0
0
0
0
0
0
4
L
28
Fenbendazole
0.007
12
0
0
5
0
0
0
0
3
0
0
20
M
29
Fenvalerate
0.02
8
4
5
2
3
0
0
3
0
2
0
27
H
30
Florfenicol
0.001
16
2
2
2
0
3
0
3
0
0
2
30
H
31
Gentamicin
0.05
8
2
2
2
3
0
0
0
0
0
0
17
L
32
Ivermectin
0.001
16
0
0
0
3
3
0
0
3
0
0
25
H
33
Kanamycin Sulfate
_
4
2
2
5
3
3
0
0
3
0
0
22
M
34
Kitasamycin
0.5
4
2
2
2
0
0
0
0
0
0
0
10
L
4
0
4
0
3
0
0
3
0
2
26
H
-3
35
Levamisole
0-6×10
36
Lincomycin Hydrochloride
0-0.03
8
5
0
0
0
3
0
3
3
0
0
22
M
37
Maduramicin ammonoium
-
4
2
0
2
0
0
0
0
0
0
0
8
L
38
Mequindox
0.025
8
2
2
5
0
0
3
0
0
0
0
20
M
39
Metronidazole
-
4
5
5
2
3
3
3
0
3
0
0
28
H
40
Monensin
0.01
12
0
0
5
3
0
0
3
3
0
0
26
L
41
Neomycin sulphate
0.06
8
0
2
0
0
0
0
3
3
2
0
18
L
42
Nicarbazin
0-0.4
4
2
2
0
0
0
0
0
3
0
0
11
L
43
Niclosamide
-
4
5
5
5
3
0
0
0
3
0
0
25
H
44
Nitroclofene
-
4
0
0
0
0
0
0
0
0
0
0
4
L
45
Norfloxacin
-
4
2
5
0
3
0
0
0
0
0
0
14
L
46
Novaldin
-
4
5
5
0
0
0
0
0
0
0
0
14
L
47
Olaquindox
0.06
8
5
5
5
0
0
0
0
0
0
0
23
M
48
Oxfendazole
0.004
12
5
5
5
0
3
0
0
3
0
0
33
H
49
Oxytetracycline
0-0.15
4
4
0
5
0
0
0
3
3
0
0
19
M
50
Paracetamol
-
4
4
5
5
3
0
0
0
3
0
2
26
H
51
Pefloxacin
-
4
2
5
0
3
0
0
0
0
0
0
14
L
52
Penicillin G Potassium
0.03
8
2
2
0
3
3
0
0
3
0
0
21
M
53
Phoxim
0.00025
16
0
0
2
3
0
0
0
3
0
0
24
H
54
Piperazine
0.25
4
0
0
0
3
3
0
0
3
0
0
13
L
55
praziquantel
0.02
8
5
0
2
3
3
0
0
3
0
0
24
H
56
Pyrantel pamoate
-
4
0
0
3
3
0
0
0
3
0
0
13
L
57
Quinapyramine
-
4
0
0
0
0
0
0
0
0
0
0
4
L
58
Rafoxanide
0.002
12
0
0
5
0
0
0
0
0
2
0
19
M
59
Salinomycin
0.005
12
2
0
5
3
0
0
0
3
0
0
25
H
60
Spectinomycin
1
4
2
0
0
0
0
0
0
3
0
0
9
L
61
Streptomycin sulphate
0.05
8
2
5
2
3
0
0
0
0
0
0
20
M
62
Sulfaclozine
-
4
2
2
2
0
0
0
0
0
0
0
10
L
63
Sulfadiazine
0.02
8
2
2
5
0
0
0
0
0
0
0
17
L
64
Sulfadimidine
0-0.05
8
4
2
5
0
3
3
0
3
0
0
28
H
65
Sulfamethoxazole
0.05
8
4
5
2
0
3
0
0
3
0
0
25
H
66
Sulfamethoxydiazine
-
4
2
2
2
3
0
0
0
0
0
0
13
L
67
Sulfamonomethoxine
0.006
12
2
2
2
3
0
0
0
0
0
0
21
M
68
Sulfaquinoxaline
0.01
12
2
2
2
0
3
0
0
3
0
0
24
H
69
Sulfathiazole
_
2
0
2
0
0
0
0
0
0
0
4
L
70
Tetracycline
0-0.03
8
2
5
5
0
0
0
3
0
0
0
23
M
71
Tilmicosin
0.002
12
2
0
0
0
0
0
0
3
0
0
17
L
72
Toltrazuril
0.002
12
5
5
2
0
0
0
0
0
0
0
24
H
73
Trichlorfon
0-0.01
12
5
5
5
3
3
3
0
3
0
0
39
H
74
Trichloroisocyanuric acid
-
4
2
0
2
0
0
0
0
3
0
0
11
L
75
Trimethoprim
0.02
8
2
5
5
0
0
0
0
3
0
0
23
M
76
Tylosin
0.03
8
5
0
2
3
0
0
3
3
0
0
24
H
The data were obtained from some databases, including TOXNET (http://www.toxnet.nlm.nih.gov), the International Programme on Chemical Safety (http://www.inchem.org) and Pesticide Database (http://www.pesticideinfo.org).
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