Defintions:
term: spindle pole
goid: GO:0030315
definition: One of the pair of centrosomes in a cell undergoing mitosis. Microtubules
radiating from these centrosomes form the mitotic spindle.
definition_reference: http://www.cytokinetics.com
Proposed def:
One end of a microtubule spindle apparatus where microtubules are organized from;
usually contains an MTOC and accessory activities, spindle microtubules and astral
microtubules.
term: centrosome
goid: GO:0005813
definition: A structure occurring close to the nucleus during interphase in many
eukaryotic cells. It comprises a pair of centrioles, satellite bodies, and a cytoplasmic zone
from which the mitotic spindle is organized. The structure of the centrosome in animal
cells changes continually during the cell-division cycle.
definition_reference: ISBN:0198547684
Proposed def:
A structure comprised of a pair of centrioles and peri-centriolar material from which a
microtubule spindle apparatus is organized. [Centrosomes occur close to the nucleus
during interphase in many eukaryotic cells, though in animl cells it changes continually
during the cell-division cycle.]
term:aster
goid: GO:0005818
definition: a microtubule emanating from a spindle pole MTOC that does not connect to
kinetochores.
definition_reference: SGD:clt
synonym: astral microtubule
term: peri-centriolar material
goid: GO:0000242
definition: A network of small fibers that surrounds the centrioles in animal cells.
definition_reference: ISBN:0815316194
Proposed def:
A network of small fibers that surrounds the centrioles in cells; contains the microtubule
nucleating activity of the centrosome.
term: basal body
goid:
definition: A short cylindrical array of microtubules and associated proteins found at the
base of a eukaryotic cilium or flagellum that is similar in structure to a centriole. The
basal body serves as a nucleation site for axoneme growth..
definition_reference:
term: equatorial microtubule organizing center
goid: GO:new
definition: A microtubule organizing center formed by a band of gamma-tubulin that is
recruited to an F-actin circumferential band, or ring, at the midpoint of a cell.
definition_reference: PMID: 11792817
GAMMA TUBULIN TERMS
term: gamma-tubulin complex
goid: GO:new
A multiprotein complex composed of gamma-tubulin and other non-tubulin
proteins. Gamma-tubulin complexes are localized to microtubule organizing
centers, and play an important role in the nucleation of microtubules. The number and
complexity of non-tubulin proteins varies between species.
PMID: 12134075
term: gamma-tubulin ring complex
goid: GO:0008274
definition: A multiprotein complex composed of gamma-tubulin other non-tubulin
proteins forming a flexible open ring structure that is thought to be the unit of nucleation
at the minus end of a microtubule.
definition_reference: PMID: 12134075
term: gamma-tubulin ring complex, centrosomal
new term
definition: A centrosome-localized multiprotein complex composed of gamma-tubulin
and other non-tubulin proteins assembled into a ring structure that is thought to be the
unit of nucleation at the minus end of a microtubule. Gamma tubulin small complexes are
thought to be the core repeating units of the ring.
definition_reference: SGD:clt
definition_reference: PMID:12134075
term: gamma-tubulin ring complex, centrosomal (sensu Animalia)
goid: GO:0008274
definition: A multiprotein complex that composed of approximately 10 - 14 gammatubulin molecules and at least six other non-tubulin proteins assembled into a flexible
open ring structure, which in animal cells has a diameter of around 25nm. It is thought to
be the unit of nucleation at the minus end of a microtubule.
definition_reference: PMID: 12134075
term: gamma-tubulin large complex
goid:
definition: A complex formed by multimerization of gamma-tubulin small complexes.
definition_reference: PMID: 12134075
term: gamma-tubulin large complex (sensu Animalia)
goid: GO:new
definition: A complex formed by multimerization of gamma-tubulin small complexes that
contains .
definition_reference: PMID: 12134075
term: gamma-tubulin large complex (sensu Schizosaccharomyces)
goid: GO:new
definition:A multiprotein complex composed of gamma-tubulin and other conserved nontubulin proteins. Thought to be composed of repeating subunits of smaller complexes
which multimerize to become MT nucleation-competent structure.
definition_reference: PMID: 12134075
term: gamma-tubulin small complex
goid:
definition: A complex usually comprising two gamma-tubulin molecules and two
conserved non-tubulin proteins. Gamma-tubulin small complexes are thought to be the
repeating unit making up the core of the gamma-tubulin ring complex.
definition_reference: PMID: 11297925
definition_reference: PMID: 12134075
term: gamma-tubulin small complex (sensu Animalia)
goid: GO:new
definition: A complex usually comprising two gamma-tubulin molecules, at least two
conserved non-tubulin proteins that multimerize along with additional non-tubulin
proteins in animal cells into larger functional complexes. Gamma-tubulin small
complexes are thought to be the repeating unit making up the core of the gamma-tubulin
ring complex.
definition_reference PMID: 12134075
term: gamma-tubulin small complex (sensu Schizosaccharomyces)
goid: GO:new
definition: A complex composed of two gamma-tubulin molecules and conserved nontubulin proteins isolated by fractionation from cells. The complex is analogous to the
small complex in animal cells and is thought to multimerize into larger functional units.
definition_reference: PMID: 12134075
term: gamma-tubulin complex (sensu Saccharomyces) synonym:Tub4 complex
goid: GO:new
definition: A complex composed of two gamma-tubulin molecules and conserved nontubulin proteins isolated by fractionation from cells. The complex is analogous to the
small complex in S. pombe and animal cells but contiains fewer subunits, and is not
thought to multimerize into larger functional units, like complexes in those organisms.
definition_reference: PMID: 12134075