Homann, Dirk
Principal Investigator/Program Director (Last, First, Middle):
BIOGRAPHICAL SKETCH
DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
Dirk Homann
Assistant Professor
eRA COMMONS USER NAME
Homann.Dirk
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
Freie Universität Berlin
Hochschule der Künste, Berlin
DEGREE
(if applicable)
YEAR(s)
M.D.
M.A.
1991
1994
FIELD OF STUDY
Medicine
Piano/Music
NOTE: The Biographical Sketch may not exceed four pages.
A. Positions and Honors.
1992-1994
Instructor for Anatomy, Physiology, Microbiology, Internal Medicine and Neurology
Urban Hospital and Jüdisches Hospital, Berlin
1995-2000
Research Associate, Viral Immunobiology Laboratory (Head: Dr. M. Oldstone),
The Scripps Research Institute
2000-2002
Senior Research Associate/Instructor, The Scripps Research Institute
2003-present Assistant Professor, Department of Pediatrics,
University of Colorado at Denver and Health Sciences Center (UCDHSC)
2003-present Visiting Professor, The Scripps Research Institute
2003-present Director, Flow Cytometry Core Facility, Barbara Davis Center/UCDHSC
2004-present Assistant Professor, Integrated Department of Immunology,
National Jewish Medical and Research Center & UCDHSC
2005-present Assistant Professor, Department of Microbiology, UCDHSC
2006-present Assistant Professor, Biomedical Sciences Program, UCDHSC
Honors:
Medical thesis: summa cum laude
Piano/Music diploma: summa cum laude
Grants by the Studienstiftung des Deutschen Volkes, Ludwig-Maximilians-Universität Munich
and German Academic Exchange Service
Multiple awards for attendance of national and international conferences (ASCI/AAP Joint
Meeting, 5th International Congress of the Immunology of Diabetes Society, XII th International
Congress of Virology and others)
Memberships: UCDHSC Cancer Center, American Association of Immunologists, American Society for
Microbiology
B. Selected Peer-Reviewed Publications (in chronological order).
von Herrath, M.G., D. Homann. Treatment of virus-induced IDDM by oral administration of insulin: Study on
the mechanism by which oral antigens can abrogate autoimmunity. Endocrinol. and Diabetes 105:24-25 (1997)
von Herrath M.G., A. Holz, D. Homann, M.B.Oldstone. Role of viruses in type I diabetes. Semin Immunol.
10:87-100 (1998)
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Homann, Dirk
Principal Investigator/Program Director (Last, First, Middle):
Homann, D., A. Tishon, D.P. Berger, W.O. Weigle, M.G. von Herrath, M.B.A. Oldstone. Evidence for an
underlying CD4 helper and CD8 T cell defect in B cell-deficient mice: failure to clear persistent virus infection
after adoptive immunotherapy with virus-specific memory cells from MT/MT mice. J. Virol. 72:9208-9216
(1998)
von Herrath, M., B. Coon, D. Homann, T. Wolfe, L.G. Guidotti. Thymic tolerance to only one viral protein
reduces lymphocytic choriomeningits virus-induced immunopathology and increases survival in perforindeficient mice. J. Virol. 73:5918-5925(1999)
Homann, D., T. Dyrberg, J. Petersen, M.B.A. Oldstone, M.G. von Herrath. Insulin in oral immune "tolerance":
A one amino acid change in the B-chain makes the difference. J. Immunol. 163:1833-1838 (1999)
Oldstone, M.B.A., H. Lewicki, D. Thomas, A. Tishon, D. White, S. Dales, J. Patterson, M. Manchester, D.
Homann, D. Naniche, A. Holz. Measles virus infection in a transgenic model: virus-induced
immunosuppression and central nervous system disease. Cell 98:629-640 (1999)
Homann, D., A. Holz, A. Bot, B. Coon, T. Wolfe, J. Petersen, T.P. Dyrberg, M.J. Grusby, M.G. von Herrath.
Autoreactive CD4+ lymphocytes protect from autoimmune diabetes via bystander suppression using the IL4/stat6 pathway. Immunity 11:463-472 (1999)
Homann, D., D.P. Berger, M.B.A. Oldstone. Defining parameters for successful immunocytotherapy of
persistent viral infection. Virology 266:257-263 (2000)
von Herrath, M.G., D.P. Berger, D. Homann, T. Tishon, A. Sette, M.B. Oldstone. Vaccination to treat persistent
viral infection. Virology 268:411-419 (2000)
Sevilla, N., D. Homann, M. von Herrath, F. Rodriguez, S. Harkins, J.L. Whitton, M.B. Oldstone. Virus-induced
diabetes in a transgenic model: role of cross-reacting viruses and quantitation of effector T cells needed to
cause disease. J. Virol. 74:3284-3292 (2000)
Sevilla, N., S. Kunz, A. Holz, H. Lewicki, D. Homann, H. Yamada, K.P. Campell, J.C. de la Torre, M.B.A.
Oldstone. Immunosuppression and resultant viral persistence by specific viral targeting of dendritic cells. J.
Exp. Med. 192:1249-1260 (2000)
Holz, A., T. Dyrberg, W. Hagopian, D. Homann, M. Von Herrath, Michael B.A. Oldstone. Neither Blymphocytes nor antibodies directed against self antigens of the islets of Langerhans are required for
development of virus-induced autoimmune diabetes. J. Immunol. 165:5945-5953 (2000)
Homann, D., D.P. Berger, M.B.A. Oldstone. Immunocytotherapy for persistent viral infection. In: New
Concepts in the Immunopathogenesis of CNS Infections. P.K. Peterson, J.S. Remington, eds., Blackwell
Science, Boston. (2000)
von Herrath, M.G., D. Homann, M.B.A. Oldstone. The role of viruses. In: Immunologically Mediated Endocrine
Diseases. R. Gill et al., eds., Lippincott Raven, Philadelphia. (2000)
Bureau, J.-F., S. Le Goff, D. Thomas, A.F. Parlow, J.C. de la Torre, D. Homann, M. Brahic, M.B.A. Oldstone.
Disruption of differentiated functions during viral infection in vivo. V. Mapping of a locus involved in
susceptibility of mice to growth hormone deficiency due to persistent lymphocytic choriomeningitis virus
infection. Virology 281:61-66 (2001)
Pertl, U., A.D. Luster, N.M. Varki, D. Homann, G. Gaedicke, R.A. Reisfeld, H.N. Lode. IFN-gamma-inducible
protein-10 is essential for the generation of a protective tumor-specific CD8 T cell response induced by singlechain IL-12 gene therapy. J. Immunol. 166:6944-6951 (2001)
Oldstone, M.B., H. Lewicki, D. Homann, C. Nguyen, S. Julien, J.E. Gairin. Common antiviral cytotoxic Tlymphocyte epitope for diverse arenaviruses. J. Virol. 75:6273-6278 (2001)
Homann, D., L. Teyton, M.B.A. Oldstone. Differential regulation of antiviral T-cell immunity results in stable
CD8+ but declining CD4+ T-cell memory. Nat. Med. 7:913-919 (2001)
von Herrath, M.G., M. Oldstone, D. Homann, U. Christen. Is activation of autoreactive lymphocytes always
detrimental? Viral infections and regulatory circuits in autoimmunity. In: Molecular Pathology of Type 1
Diabetes mellitus. Curr. Dir. Autoimmun. Vol.4, M.G. von Herrath, ed., Basel, Karger (2001)
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Homann, Dirk
Principal Investigator/Program Director (Last, First, Middle):
Homann, D., M.B.A. Oldstone. Maintaining immunity: a tale of two T cell populations. Directions in Science
1:21-24 (2002)
Hugues, S., E. Mougneau, W. Ferlin, D. Jeske, P Hofman, D. Homann, L. Beaudoin, C. Schrike, M. von
Herrath, A. Lehuen, N. Glaichenhaus. Tolerance to islet antigens and prevention of diabetes induced by limited
apoptosis of pancreatic  cells. Immunity 16:169-181 (2002)
Homann, D., A. Jahreis, T. Wolfe, A. Hughes, B. Coon, M. van Stipdonk, K.R. Prilliman, S.P. Schoenberger,
and M.G. von Herrath. CD40L blockade prevents autoimmune diabetes by induction of bitypic NK/DC
regulatory cells. Immunity 16:403-415 (2002)
Arbour, N., D. Naniche, D. Homann, R.J. Davis, R.A. Flavell, M.B.A. Oldstone. c-Jun NH2-terminal kinase
(JNK)1 and JNK2 signaling pathways have divergent roles in CD8+ T cell-mediated antiviral immunity. J. Exp.
Med. 195:801-810 (2002)
Oldstone. M.B., D. Homann, H. Lewicki, D. Stevenson. One, two, or three step: measles virus receptor dance.
Virology. 299:162-163 (2002)
McGavern, D., D. Homann, M.B.A. Oldstone. T cells in the central nervous system: the delicate balance
between viral clearance and disease. J. Infect. Dis. 186:S145-S151 (2002)
Homann, D. Immunocytotherapy. In: Arenaviruses II, Curr. Top. Microbiol. Immunol. 263:43-65, M.B.A.
Oldstone, ed., (2002)
Mallet-Designé, V., T. Stratmann, D. Homann, F. Carbone, M.B.A. Oldstone, L. Teyton. Detection of lowavidity CD4+ T cells using recombinant artificial APC: following the anti-ovalbumin immune response. J.
Immunol. 170:123-131 (2003)
Lewicki, H., A. Tishon, D. Homann, H. Mazarguil, F. Laval, VC. Asensio, I.L. Campbell, S. DeArmond, B.
Coon, C. Teng, J.E. Gairin, M.B. Oldstone. T cells infiltrate the brain in murine and human transmissible
spongiform encephalopathies. J. Virol. 77:3799-3808 (2003)
Hahm, B., N. Arbour, D. Naniche, D. Homann, M. Manchester, M.B.A. Oldstone. Measles virus infects and
suppresses proliferation of T lymphocytes from transgenic mice bearing human signaling lymphocytic
activation molecule. J. Virol. 77:3505-3515 (2003)
Slifka, M.K., D. Homann, A. Tishon, R. Pagarigan, M.B.A. Oldstone. Measles virus infection results in
suppression of both innate and adaptive immune responses to secondary bacterial infection. J. Clin. Invest.
111:805-810 (2003)
Petersen, J.S., S. Bregenholt, V. Apostolopolous, D. Homann, T. Wolfe, A. Hughes, K. De Jongh, M. Wang, T.
Dyrberg, M.G. von Herrath. Coupling of oral human or porcine insulin to the B subunit of cholera toxin (CTB)
overcomes critical antigenic differences for prevention of type I diabetes. Clin. Exp. Immunol. 134:38-45 (2003)
De Boer, R.J., D. Homann, A.S. Perelson. Different dynamics of CD4+ and CD8+ T cell responses during and
after acute LCMV infection. J. Immunol. 171:3928-3935 (2003)
von Herrath, M.G., D. Homann. Introducing baselines for therapeutic use of regulatory T cells and cytokines in
autoimmunity. Trends Immunol. 24:540-545 (2003)
Homann, D., M.G. von Herrath. Interfacing dendritic and natural killer cells: a tool for targeted tolerance
induction? Transplantation. 76:1657-1661 (2003)
von Herrath, M.G., D. Homann. Organ-specific autoimmunity. In: Fundamental Immunology. W.E. Paul, ed.,
5th edition, Lippincott Williams & Wilkins, Philadelphia (2003)
Christen, U., Juedes, A., Homann, D., von Herrath, M.G. Virally induced inflammation and therapeutic
avenues in type 1 diabetes mellitus. Endocrinol. Metab. Clin. North Am. 33:45-58 (2004)
Homann, D., D. McGavern, M.B.A. Oldstone. Visualizing the viral burden: phenotypic and functional
alterations of T cells and antigen-presenting cells during persistent infection. J. Immunol. 172:6239-6250
(2004)
von Herrath, M.G., D. Homann. Tolerance tag team. Nat. Med. 10:585-587 (2004)
Lenz, D.C., S.K. Kurz, E. Lemmens, S.P. Schoenberger, J. Sprent, M.B.A. Oldstone, D. Homann. IL-7
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Homann, Dirk
Principal Investigator/Program Director (Last, First, Middle):
regulates basal homeostatic proliferation of antiviral CD4+ T cell memory. Proc. Natl. Acad. Sci. USA.
101:9357-9362 (2004)
Homann, D., von Herrath M.G. Regulatory T cells and type 1 diabetes. Clin. Immunol. 112:202-209 (2004)
Homann, D., Gill, R.G. To help and help not. Nat. Immunol. 5:878-880 (2004)
von Herrath, M.G., D. Homann. Islet regeneration needed for overcoming autoimmune destruction considerations on the pathogenesis of type 1 diabetes. Pediatr. Diabetes. Suppl. 2:23-28 (2004)
Homann, D., M.G. von Herrath. “Natural” and “induced” regulatory T cells – purpose and problems associated
with an emerging distinction. In: Regulatory T cells in inflammation. Progress in Inflammation Research. L.
Taams et al., eds., Birkhäuser Verlag, Basel (2005)
Homann, D., W. Dummer, T. Wolfe, E. Rodrigo, A.N. Theofilopoulos, M.B.A. Oldstone, M.G. von Herrath. Lack
of intrinsic CTLA-4 expression has minimal effect on regulation of antiviral T cell immunity. J. Virol. 80:270-280
(2006)
Homann, D., G. S. Eisenbarth. An Immunologic Homunculus for Type 1 Diabetes of the NOD Mouse. J. Clin.
Invest. 116:1212-1215 (2006)
Martinic, M.M., A.E. Juedes, D. Bresson, D. Homann, K. Skak, C. Huber, E. Ling, M. Ejrnaes, T. Wolfe, L.
Togher, E. Rodrigo, M. Kotturi, R. Tan, X. Wang, U. Christen, and M.G. von Herrath. Minimal impact of a de
novo-expressed β-cell autoantigen on spontaneous diabetes development in NOD mice. Diabetes 56:10591068 (2007)
Homann, D., H. Lewicki, D. Brooks, J. Eberlein, V. Mallet-Designé, L. Teyton, M.B.A. Oldstone. Mapping and
restriction of a dominant viral CD4+T cell core epitope by both MHC class I and MHC class II. Virology in press
(2007)
von Herrath, M.G., D. Homann. Organ-specific autoimmunity. In: Fundamental Immunology. W.E. Paul, ed.,
6th edition, Lippincott Williams & Wilkins, Philadelphia in press
C. Research Support.
Completed and active:


BDC start up funds
Role PI
Funding period: 09/01/03 – 08/31/06
BDC P&F grant: “On the pathogenesis of type 1 diabetes: an RNA interference approach”
Role: PI
Funding period: 04/01/04 – 03/31/05
Goals: Use of retrovirus-based RNA interference to modulate selected properties of pathogenic CD8+T
cells in an in vivo model for type 1 diabetes.

NIH 1R21 AG026518-01: “Maturation of established antiviral CD8+T cell memory”
Role: PI
Funding period: 07/01/05 – 06/30/07
Goals: Molecular and functional characterization of improved CD8+ memory T cell properties acquired
during an extended maturation period.

NIH 1R01AI059777-01A1: “Cell cycle inhibition in systemic autoimmunity” (Dwight Kono, PI)
Role: Collaborator Funding period: 02/15/05 – 01/31/10
Goals: Defining the role of the cell cycle inhibitor p21 in normal immune and autoimmune responses.

NIH 2R01 DK055969-08 “In vivo NOD evaluation of a “pathogenic” insulin peptide” (G. Eisenbarth, PI)
Role: Co-InvestigatorFunding period: 03/01/06 – 02/28/10

JDRF CDA 2-2007-240: “Chemokine signatures in pathogenesis and prevention of type 1 diabetes”
Role: PI
Funding period: 04/01/07 – 03/31/12
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Homann, Dirk
Principal Investigator/Program Director (Last, First, Middle):
Goals: Deliniation of “chemokine signatures” of diabetogenic T cells and islet cells, evaluation of the
pathogenetic role of selected chemokines and identification of chemokine/receptors as therapeutic targets.
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