Supplementary Table S2 Members of Key Signaling Pathways
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Supplementary Table S2 Members of Key Signaling Pathways Target Gene Key pathway Role Axin2/conductin Wnt signaling pathway Inhibitor of wnt signaling, associates APC/catenin/GSK3/DVL Ctnnb1/ catenin Wnt signaling pathway Dkk1/dickkopf homolog 1 Wnt signaling pathway Dvl3/dishevelled 3 Wnt signaling pathway Jup/Ctnng plakoglobin/-catenin Wnt signaling pathway Associates APC and axin Possible TCF/LEF transcriptional activity Ppp2r2b Wnt signaling pathway Modulation of PP2A activity Wnt3a Wnt signaling pathway AP elongation, somite, tailbud formation Map2k5/MEK5 MapK signaling pathway In vivo activator of ERK5 Map3k11/PTK1/MLK3 MapK signaling pathway Positive regulator JNK signaling Map3k2/MEKK2 Map3k3/MEKK3 Cdc42ep5/CEP5 MapK signaling pathway MapK signaling pathway c-Jun N-Terminal Kinase (JNK) pathway LEF/TCF dependent transcriptional activation Antagonist wnt signaling, anterior side embryo Dvl1/3 <<< Dvl2 pool Signaling canonical pathway sensitive to Dvl3 levels Non-canonical & additional pathways Crosstalk TGF pathway (Smad 3) Crosstalk MEKK1 SAPK stress pathway A Component of adherens junctions JNK signaling PCP pathway Nodal pathway A Component of adherens junctions and desmosomal plaques Tight junctions JNK signaling PCP pathway Activates MEK5 Required for T cell signaling Activates MEK5 cardiovascular development NF- signaling JNK pathway TNF signaling GnRH signaling pathway GnRH signaling pathway Regulation of cell shape Rho GTPase Smad interacting protein NF- signaling B cell Receptor Signaling T cell Receptor Signaling Ras/MAPK signaling Junb JNK pathway Regulates erythroid cell survival, proliferation, and differentiation Syk JNK pathway Cell-cell adhesion via E cadherin & catenin BMP1 TGF signaling pathway Tolloid related Fut 8 TGF signaling pathway Required for VEGFR2 expression GDF5 TGF signaling Embryonic limb morphogenesis N-glycan biosynthesis Keratin sulphate biosynthesis Integrin mediated signaling Cytokine-cytokine pathway BOC Hedgehog Signaling pathway ERG Fgf signaling FGF8 Fgf signaling Adam 19 Integrin signaling Adam 24 Testase 1 Integrin signaling Rhou / WRCH1 Integrin signaling Akap10 (D-AKAP2) G-protein Coupled Receptor signaling Arhgef4 G-protein Coupled Receptor signaling Camk2a G-protein Coupled Receptor signaling Gnaq G-protein Coupled Receptor signaling Gnaz Gnb2l1/Rack1 Ptk2b, Pyk2, Raftk Lphn3/LEC3 Rgs2 Sstr3 Bcl6 Chn2 Dpp4/CD26 Zap70 receptor interaction Robo related, sonic hedgehog receptor Required myogenesis Regulation angiogenesis L-R determinant, competence to respond to nodal signals Heart development & dendritic cell marker Protease implicated in sperm function during epididymal maturation or fertilization Wnt-1 responsive Cdc42 hom stimulates cells to reenter the cell cycle Localisation camp dep PKA , implicated heart rhythm regulation cell migration & cell-cell adhesion Vascular smooth muscle contraction cell morphogenesis Receptor signaling B cell receptor signaling actin cytoskeleton signaling AMP mediated signaling Rho guanine nucleotide exchange factor B cell receptor signaling GnRH signaling pathway Wnt pathway G-protein Coupled Receptor signaling G-protein Coupled Receptor signaling Localized to proliferating endothelial cells G-protein Coupled Receptor signaling Cell adhesion Activation EGFR GnRH signaling pathway Calcium signaling pathway G-protein Coupled Receptor signaling Ca2+independent receptor neuropeptide signaling pathway G-protein Coupled Receptor signaling G-protein Coupled Receptor signaling B cell Receptor signaling T cell Receptor signaling T cell Receptor signaling T cell Receptor signaling Negative regulator of G coupled receptor signalling May activate G-proteins at tight junctions Repressor of transcription, memory B cell development Neuroactive ligandreceptor interaction Proliferation & migration SMC Rac-specific GTPase activating proteins IL6 Cytokine/Jak/STAT pathway Lif Cytokine/Jak/STAT pathway Like syk non receptor PK. Associates TCR zeta chain First cytokine developing circulation osteoblasts to osteoclasts Down regulated on differentiation cell morphogenesis NK- signaling Gastrulation is inhibited in mouse embryos overexpressing LIF Lifr Cytokine/Jak/STAT pathway Acly Insulin Receptor signaling TGF Pck2/PEPCK Gcnt2 Neu3 St8sia3 Hsd17b3 ErbB/HER signaling PPAR signaling pathway Sphingolipid Metabolism & NGlycan Metabolism Sphingolipid Metabolism & NGlycan Metabolism Sphingolipid Metabolism & NGlycan Metabolism Androgen & Estrogen Metabolism St6galnac1 O-glycan Biosysnthesis Pde2aPdpk1 Purine Metabolism Pde7b Purine Metabolism Purine & Pyrimidine Metabolism Purine Metabolism Protein Ubiquitination pathway Protein Ubiquitination pathway Protein Ubiquitination pathway Protein Ubiquitination pathway NEDD8 conjugation pathway NFR2 Mediated Oxidative Stress Response NFR2 Mediated Oxidative Stress Response Pold3 Prune Nedd4l Sumo2 Usp18 Usp25 Appbp1 Ephx1 Gstm7 Down regulated on differentiation Synthesis Acetyl CoA May have additional tissue specific function development Angiogenesis, cell proliferation TCA cycle CO2 fixation Adipocytokine signaling pathway Branching enzyme responsible conversion fetal to adult blood antigens skeletal muscle differentiation Suppression of apoptosis Mobilises membrane ruffles Fetal blood formation & neuronal development Lipid biosynthesis Decreases cell adhesion & increases cell migration Phosphodiesterase activity Cell communication Phosphodiesterase activity DNA replication & repair subunit DNA pol Pyrophosphatase activity ubiquitin protein-ligase activity Protein modification NK- signaling Deubiquitinating enzyme Deubiquitinating enzyme Neddylation Apoptosis and cell cycle progression Protective enzyme Glutathione metabolism Rab5b Clathrin & Calveolar Mediated Endocytosis Establishment of localization small GTPase mediated signal transduction Abcc2Mrp2 RXR Activation Membrane transport multidrug resistance ABC Transport Robo4 Src Family Kinase Activation Vascular -specific inhibits endothelial migration Slit-Robo signaling Cit Dscr1l1 Rcan2 Protein serine/threonine kinase activity Calcium mediated signaling Tissue specific neural tube regulator of cytokinesis Regulation of calcineurin Rho interacting kinase calcineurin-NFAT pathway.
