Appendix: Additional Tables Table I. Summary of Reviewed Case Reports. Study Study design Sample, diagnoses Intervention, duration Schwöbel (1954) Case report; assessment points: before and after treatment; follow-up one year later Case report; assessment points: before and after inpatient treatment; follow-ups: two and 12 months n=2 women (43 and 59 years); Menière’s disease Psychoanalysis; duration: case 1: 1.5 years (52 hours); case 2: 3 months n=1 woman (58 years); positional nystagmus (peripheral) 13 (28.3%) n=1 man (42 years); Menière’s disease and anxiety In-patient: daily records of progress; distance in feet walked per day; After discharge: daily records of walking and homemaking activities Control over vertigo attacks, time off work, social activities, coping with stress; At discharge: able to walk 1200 feet; Two months later: no more usage of wheelchair; 12 months later: able to walk and to conduct homemaking activities Case report; assessment points: before treatment; follow-ups: monthly until one year after treatment Case report; assessment points: before and after treatment, follow-ups: 2, 4, and 8 weeks Behavioural therapy (inpatient): positive and negative reinforcement; physical therapy (in-patient): standing in parallel bars, walking; duration: 55 days (in-patient); after discharge: meetings with physical therapist and psychologist Behavioural treatment: relaxation techniques twice daily; meditation; when anxious: graded behavioural tasks; biofeedback; duration: 12 months One year after treatment: more control over vertigo and Menière attacks; less anxiety; not many time off work; better stress coping abilities 11 (23.9%) Behavioural treatment: education about BPV; selfmonitoring; gaze-fixation; desensitization; biofeedbackassisted relaxation training; stress management; cognitive strategies; duration: 9 weeks Psychophysiologic measures; recordings: frequency and severity of dizzy spells; activity and well-being After treatment: reduced frequency and severity of dizzy spells; reduced muscle tension; increased peripheral blood flow; increased confidence in ability to manage dizzy spells; increased social 16 (34.8%) Fowler et al. (1971) Elwood et al. (1982) Shutty et al. (1991) n=1 woman (26 years); mild head injury after accident, BPV, and avoidance Measurements Results After treatment: no vertigo symptoms, no social withdrawal, happy mood, working Quality assessment ratinga 11 (23.9%) 1 Andersson & Yardley (1998) Case report; assessment points: before and after treatment; follow-up: three months n=1 woman (68 years); dizziness, fear of falling, and avoidance CBT and VR: education about dizziness; balance / movement exercises; relaxation for difficult situations; positive / negative thoughts; vicious circles; expectations; duration: 10 weeks (five sessions, one phone call) Hägnebo et al. (1998) Case report; assessment points: before and after treatment; follow-ups: 3, 6, 10, and 24 months n=1 woman (62 years); Menière’s disease and anxiety / worries Sareen (2003) Case report, assessment points: before and after treatment; follow-up: 6 months Case report; assessment points: before treatment, after behavioural therapy and after vestibular therapy n=1 woman (35 years); dizziness, anxiety, and avoidance CBT: relaxation training; desensitization of anxietyprovoking situations; cognitive restructuring; behavioural task setting; enhancement of bodily awareness; duration: 9 weeks (in addition: 2 Booster sessions at 6 months after treatment) Behavioural treatment: education about dizziness; daily exposure to dizziness; Duration: 4 sessions Whitney et al. (2005) n=1 man (37 years); fear of heights and dizziness Behavioural therapy: exposure to virtual height scenes; duration: 8 sessions; Followed by vestibular therapy: exercises; duration: 8 weeks Questionnaire: VHS; neurootological testing: eye movements, reflexes, caloric test, dynamic posturography; behaviour provocation test Clinical interview; recordings: number of vertigo attacks and of positive / negative events activities; less psychological distress; Follow-ups: increased activity and well-being After treatment: improved balance, equilibrium score, and behaviour provocation; Pre to post to follow-up: Improved VHS 18.5 (40.2%) After treatment: no more vertigo attacks; At 24 months: no more vertigo attacks; normal social functioning, less worries 19 (41.3%) episodes of dizziness After treatment: no more dizziness; Follow-up: maintained improvement 9 (19.6%) Expert interview; questionnaires: CAQ, ATHQ, SitQ, IIRS, DHI; SF-36, behavioural avoidance test; optic flow testing After behavioural therapy: reduced anxiety and avoidance of heights; increased quality of life; persistent symptoms of dizziness and discomfort of space and motion; After vestibular therapy: reduced anxiety and avoidance of heights; less 17.5 (38.0%) 2 Goto et al. (2008a) Goto et al. (2008b) Sardinha et al. (2009) Case report; assessment points: before and during treatment; follow-ups: 6 and 9 months Case report; assessment points: before and during treatment; follow-ups: 6 and 9 months n=1 man (51 years); Menière’s disease, anxiety, and insomnia Psychotherapy and AT (three times daily); duration: 6 sessions, every three weeks Questionnaires: SDS, STAI, CMI, Y-G n=1 woman (37 years); PPV, anxiety, insomnia, headache, and tinnitus Medication: antidepressant, herbal medicine; Psychotherapy and AT (three times daily); duration: 6 sessions (à 45 minutes), every three weeks Questionnaires: SDS, STAI, CMI, MAS, MOCI Case report; assessment points: before and during treatment n=1 man (17 years); vestibular neuritis and subsequently PPV Cognitive-behavioural therapy: cognitive interventions, making plans for the future, information about associations between avoidance / hypervigilance and problem maintenance, increase of activities, exposure to avoided activities; duration: 18 weeks (one session per week) Patient’s reports: frequency and intensity of dizziness episodes, anxiety, mood, well -being, activities perceived dizziness handicap; less visually dependent; improved quality of life; better daily functioning After a few weeks: no more vertigo, tinnitus, and insomnia; At follow-ups: no more vertigo and insomnia After 2 weeks: symptoms slightly improved, medication was stopped; After a few weeks: no more dizziness, insomnia, and headache; Follow-ups: no more dizziness, insomnia, and headache At the end of treatment: no more dizziness, increased activities and well-being 13 (28.3%) 13 (28.3%) 11 (23.9%) a The quality assessment rating score (Moncrieff et al., 2001) could range between 0 (very poor study quality) and 46 (excellent study quality); in parentheses the proportion (in per cent) is reported. Abbreviations: AT=autogenic training; ATHQ=Attitudes Towards Heights Questionnaire; BPV=benign positional vertigo; CAQ=Cohen Acrophobia Questionnaire; CBT=Cognitive-behavioural therapy; CMI=Cornell Medical Index; IIRS=Illness Intrusiveness Ratings Scale; DHI=Dizziness Handicap Inventory; MAS=Manifest Anxiety Scale; MI=Mobility Inventory; MOCI=Maudsley Obsessional-Compulsive Inventory; PPV=Phobic postural vertigo; SitQ=Situational Characteristics Questionnaire; SDS=Self-rating Depression Scale; STAI(-t)=State-Trait Anxiety Inventory (trait form); VHS=Vertigo Handicap Scale; VR=vestibular rehabilitation; Y-G=Yatabe-Guilford personality test 3 Table II. Summary of Reviewed Psychotherapy or Follow-up Studies. Study Study design Sample, diagnoses Control group Intervention, duration Measurements Results Huppert et al. (2005) Follow-up study; assessment points: before treatment; follow-up: 5 to 15 years N=303 were sent a questionnaire n=106 (35%) completed it (n=42 women, n=64 men; mean age 44.3 years); PPV No Self-reported changes: symptom-free / considerably improved, no change Symptom-free or considerably improved: 75%, independently of age, sex, prior organic vertigo, or other subsequent therapies; most improvement within the first year after initial treatment; Heinrichs et al. (2003) Psychotherapy study (natural design); assessment points: before treatment; follow-ups: 6 weeks and one year Initially: n=398 (n=266 women, n=132 men; mean age 35.5 years); vertigo and agoraphobia 6 weeks post: n=398 (100%) One year post: n=300 (75.4%) No Initial: self-controlled behavioural therapy: explanation of PPV; decoupling of catastrophic thoughts; exposure to vertigo triggering situations; regular physical activity; duration: 2-3 sessions; During follow-up period: psychotherapy (not specified); pharmacotherapy, physiotherapy; alternative therapies; CBT (individualized): Information about the disorder and therapy procedure; intensive invivo exposure with anxiety triggering stimuli up to 12 hours daily; self-control period; duration: > 3 weeks Questionnaires: BAI, BDI, BSQ, ACQ, MI, SCL-90-R After 6 weeks: improvement in all measurements; After one year: effects remained stable Quality assessment ratinga 21 (45.7%) 21.5 (46.7%) a The quality assessment rating score (Moncrieff et al., 2001) could range between 0 (very poor study quality) and 46 (excellent study quality); in parentheses the proportion (in per cent) is reported. Abbreviations: ACQ=Agoraphobic Cognitions Questionnaire; BAI=Beck Anxiety Inventory; BDI=Beck Depression Inventory; BSQ=Body Sensation Questionnaire; CBT=Cognitive-behavioural therapy; MI=Mobility Inventory; PPV=Phobic postural vertigo; SCL-90(-R)=Symptom Checklist 90 (revised); 4